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    Psoriasis: a mixed autoimmune and autoinflammatory disease.
    Curr Opin Immunol 2017 Jul 21;49:1-8. Epub 2017 Jul 21.
    Department of Dermatology, University of Michigan, 1910 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:
    In recent years marked progress has been made in our understanding of the critical biologic and immunologic pathways involved in psoriasis. Genetic studies have demonstrated that susceptibility to psoriasis involves components of both the adaptive and innate immune system and not surprisingly activation of both of these arms of the immune system is found in psoriatic skin. While adaptive immune responses predominate in chronic plaque psoriasis, innate and autoinflammatory responses dominate in pustular forms of psoriasis, with other clinical subtypes extending on a spectrum between plaque and pustular psoriasis. Read More

    Impact of a Patient Support Program on Patient Adherence to Adalimumab and Direct Medical Costs in Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis, Psoriasis, Psoriatic Arthritis, and Ankylosing Spondylitis.
    J Manag Care Spec Pharm 2017 Aug 15;23(8):859-867. Epub 2017 Mar 15.
    2 AbbVie, North Chicago, Illinois.
    Background: AbbVie provides a free-to-patient patient support program (PSP) to assist adalimumab-treated patients with medication costs, nurse support, injection training, pen disposal, and medication reminders. The impact of these services on patient adherence to adalimumab and direct medical costs associated with autoimmune disease has not been assessed.

    Objective: To quantify the relationship between participation in a PSP and outcomes (adalimumab adherence, persistence, and direct medical costs) in patients initiating adalimumab treatment. Read More

    Risk of Cancer Recurrence Among Individuals Exposed to Antitumor Necrosis Factor Therapy: A Systematic Review and Meta-Analysis of Observational Studies.
    J Clin Gastroenterol 2017 Jul 21. Epub 2017 Jul 21.
    *Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, IL †Indiana University School of Medicine, Indianapolis, IN.
    Background: Patients with immune-mediated disorders such as ankylosing spondylitis, inflammatory bowel disease, psoriasis and rheumatoid arthritis are increasingly treated with tumor necrosis factor (TNF) inhibitors. The safety of anti-TNF therapy in patients with a history of cancer requires further evaluation. We conducted a systematic review and a meta-analysis of observational studies including patients with a history of cancer exposed to anti-TNF therapy assessing for a risk of new cancer or cancer recurrence. Read More

    Secukinumab improves scalp pain, itching, scaling, and quality of life in patients with moderate-to-severe scalp psoriasis.
    J Dermatolog Treat 2017 Jul 24:1-19. Epub 2017 Jul 24.
    e Icahn School of Medicine at Mount Sinai and Mount Sinai St. Luke's 1090 Amsterdam Ave Suite 11B , New York , NY 10025.
    Introduction: Scalp psoriasis adversely affects patients' lives and is often resistant to treatment however it has not been a major focus of a clinical study. This analysis assessed the effect of secukinumab on patient-reported outcomes (PRO) of scalp psoriasis.

    Methods: A randomized, double-blind, placebo-controlled, multicenter study was conducted in 102 adult patients with moderate-to-severe scalp psoriasis. Read More

    Development of paradoxical inflammatory disorders during treatment of psoriasis with TNF inhibitors: a review of published cases.
    Int J Dermatol 2017 Jul 24. Epub 2017 Jul 24.
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
    Background: TNF inhibitors have proven to be effective and relatively safe in the management of psoriasis. While infections and certain malignancies are established as acknowledged side effects, paradoxical inflammatory, non-neoplastic, noninfectious adverse events are being recognized less frequently. We aimed to identify published, peer-reviewed cases of paradoxical inflammatory, non-neoplastic, noninfectious adverse events in psoriasis patients during TNF inhibitor therapy. Read More

    Imiquimod-induced Psoriasis-like inflammation in differentiated Human keratinocytes: its evaluation using curcumin.
    Eur J Pharmacol 2017 Jul 20. Epub 2017 Jul 20.
    Research and Development, The Himalaya Drug Company, Bangalore 562 162, India.
    Psoriasis is considered to be a systemic disease of immune dysfunction. It is still unclear what triggers the inflammatory cascade associated with psoriasis but recent evidences suggest the vital role of IL-23/IL-17A cytokine axis in etiology of psoriasis. Several studies have been conducted in psoriatic-like animal models but ethical issues and complexity surrounding it halts the screening of new anti-psoriatic drug candidates. Read More

    Patients with hidradenitis suppurativa have a high psychiatric disease burden: A Finnish nationwide registry study.
    J Invest Dermatol 2017 Jul 20. Epub 2017 Jul 20.
    PEDEGO Research Unit, University of Oulu; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland. Electronic address:
    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of hair follicles which is associated with various comorbidities. In order further to clarify the associations between HS and psychiatric disorders, we conducted a nationwide retrospective study that included 4381 patients with HS and 39554 psoriasis and 43248 melanocytic nevi patients as controls. Patient data were obtained from the statutory Finnish Care Register for Health Care. Read More

    Decreased Hepatitis B vaccine response in pediatric patients with atopic dermatitis, psoriasis, and morphea.
    Vaccine 2017 Jul 20. Epub 2017 Jul 20.
    Section of Pediatric Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.
    Multiple groups of patients have been recognized for having high rates of non-responders to the Hepatitis B vaccine including those with HIV, inflammatory bowel disease, and chronic kidney disease. These patients are at increased risk for infection due to both the nature of their underlying diseases and the immunosuppressive drugs they are commonly prescribed. Identification of groups with high non-response rates is essential in order to establish vaccination guidelines and prevent serious infections in already susceptible patients. Read More

    Investigation of dietary supplements prevalence as complementary therapy: Comparison between hospitalized psoriasis patients and non-psoriasis patients, correlation with disease severity and quality of life.
    Complement Ther Med 2017 Aug 23;33:65-71. Epub 2017 Jun 23.
    Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Objectives: Psoriasis patients are often displeased with traditional medical treatments and they may self-prescribe dietary supplements as an alternative or complementary treatments. We aimed to investigate the prevalence of self-medication of dietary supplements among psoriasis and non-psoriasis cases and its impact on disease severity and quality of life.

    Design And Setting: This case-control study evaluated 252 records of psoriasis patients and 245 non-psoriasis cases. Read More

    Does Treatment of Psoriasis Reduce Cardiovascular Comorbidities?
    J Invest Dermatol 2017 Aug;137(8):1612-1613
    Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
    Psoriasis has been associated with an increase in myocardial infarctions. Several registries have shown reductions in major adverse cardiovascular events in psoriasis patients and rheumatoid arthritis patients treated with tumor necrosis factor-α antagonists. Many assume that the reduction in cardiovascular events can be attributed to the anti-inflammatory effect of tumor necrosis factor blockers, but a 52-week study conducted by Bissonnette and coworkers failed to show a reduction in cardiovascular inflammation in psoriasis patients treated with adalimumab. Read More

    Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis.
    J Invest Dermatol 2017 Aug;137(8):1609-1611
    School of Molecular Sciences, The University of Western Australia, Perth, WA, Australia.
    Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Read More

    Treatment of Moderate to Severe Psoriasis With High-Dose (450-mg) Secukinumab: Case Reports of Off-Label Use.
    J Cutan Med Surg 2017 Jul 1:1203475417721424. Epub 2017 Jul 1.
    2 Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
    Treatment of moderate to severe psoriasis often requires systemic therapy, including biologics. Partial response to biologics and relapses are commonly managed with dose escalation. Secukinumab is a relatively new biologic that is currently used to treat moderate to severe psoriasis. Read More

    Inflammatory Joint Disorders and Neutrophilic Dermatoses: a Comprehensive Review.
    Clin Rev Allergy Immunol 2017 Jul 22. Epub 2017 Jul 22.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Unità Operativa di Dermatologia, Università degli Studi di Milano, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
    Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and psoriasis, and rare diseases like neutrophilic dermatoses. The latter are clinically characterised by polymorphic lesions, including pustules, bullae, abscesses, papules, nodules, plaques and ulcers, and histologically by neutrophil-rich inflammatory infiltrates. Read More

    Dimethyl fumarate modulates neutrophil extracellular trap formation in a glutathione and superoxide-dependent manner.
    Br J Dermatol 2017 Jul 22. Epub 2017 Jul 22.
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
    Background: Neutrophil (polymorphonuclear) granulocytes (PMN) were shown to contribute to the pathogenesis of psoriasis by releasing IL-17 and LL-37/ DNA complexes via neutrophil extracellular traps (NET), webs of chromatin strands decorated with antimicrobial peptides, in psoriatic skin. Fumaderm(®) , a fumaric acid ester (FAE) formulation consisting of different FAE salts has been successfully used to treat psoriasis for decades. Most recently, FAE treatment was reported to inhibit NET formation in murine epidermolysis bullosa acquisita. Read More

    Severe subcutaneous hematoma in a patient with psoriatic arthritis: Changes of platelet count in psoriatic patients with biologic agents.
    J Dermatol 2017 Jul 22. Epub 2017 Jul 22.
    Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
    The effectiveness of biologics has changed therapeutic strategies for psoriasis dramatically, but biologics are known to have various adverse effects. We report a 63-year-old woman with psoriatic arthritis who suddenly developed a subcutaneous hematoma after being successfully treated with adalimumab. As she had also suffered from alcoholic cirrhosis, we speculated that she had developed thrombocytopenia severe enough to cause a subcutaneous hematoma. Read More

    Oral glucocorticoid use and osteonecrosis in children and adults with chronic inflammatory diseases: a population-based cohort study.
    BMJ Open 2017 Jul 21;7(7):e016788. Epub 2017 Jul 21.
    Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    Objectives: We studied oral glucocorticoids and osteonecrosis, a rare but serious bone disease, in individuals with various chronic inflammatory diseases. We hypothesised that we would find stronger associations in adults versus children and in people with autoimmune diseases.

    Design: Retrospective cohort study. Read More

    Controlling the pro-inflammatory function of 6-sulfo LacNAc (slan) dendritic cells with dimethylfumarate.
    J Dermatol Sci 2017 Jun 24. Epub 2017 Jun 24.
    Department of Dermatology, University Hospital Heidelberg, Germany. Electronic address:
    Backround: The fumaric acid ester (FAE) dimethylfumarate (DMF) is a small molecule immunomodulator successfully used for the treatment of psoriasis and multiple sclerosis (MS). DMF is thought to inhibit pathogenic immune responses with Th17/Th1T cells, and IL-23/IL-12 producing dendritic cells (DCs). 6-sulfo LacNAc expressing dendritic cells (slanDCs) are a human pro-inflammatory cell type found frequently among the infiltrating leukocytes in skin lesions of psoriasis and brain lesions of MS. Read More

    Secukinumab in the Treatment of Psoriasis and Psoriatic Arthritis: A Review of the Literature.
    Skin Therapy Lett 2017 07;22(4):1-6
    Department of Dermatology, Psoriasis and Skin Treatment Center, University of California - San Francisco, San Francisco, CA, USA.
    While there are several commercially available treatment options for psoriasis and psoriatic arthritis, there remains a large number of individuals who are refractory to current modalities. In the recent past, there has been increasing evidence that interleukin (IL)-17 plays a vital role in the pathophysiology of psoriasis. Preclinical, phase II, and phase III studies of secukinumab (Cosentyx®) targeting IL-17 and its receptor have thus far proved to be promising. Read More

    Prevalence of Sacroiliitis in Inflammatory Bowel Disease Using a Standardized CT Scoring System.
    Arthritis Care Res (Hoboken) 2017 Jul 21. Epub 2017 Jul 21.
    Spondylitis Program, Toronto Western Hospital; Toronto, Canada. Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON.
    Objectives: There is an increasing emphasis on early identification and treatment of ankylosing spondylitis (AS) of which the hallmark is sacroiliitis. Patients with inflammatory bowel disease (IBD) are at increased risk of AS and often receive CT scans of their abdomen affording clinicians the opportunity to determine the presence of sacroiliitis. Previous studies using CT have relied only on radiologist's gestalt or a non-validated adaptation of the mNY criteria. Read More

    Methotrexate iontophoresis versus coal tar ointment in palmoplantar psoriasis: A pilot study.
    Indian J Dermatol Venereol Leprol 2017 Jul 20. Epub 2017 Jul 20.
    Department of Radiodiagnosis, Government Medical College, Thrissur, Kerala, India.
    Background: Palmoplantar psoriasis is often disabling and refractory to conventional therapy. Systemic drugs are indicated in its severe form, but side effects are a concern with their use. Methotrexate is one such systemic drug which is effective and cheap. Read More

    Evaluation of in vitro anti-psoriatic activity of a novel polyherbal formulation by multiparametric analysis.
    Antiinflamm Antiallergy Agents Med Chem 2017 Jul 20. Epub 2017 Jul 20.
    Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh-201010. India.
    The beneficial role of traditional herbal medicines in the treatment of inflammatory skin disorders has been widely reported. Psoriasis is characterized by uncontrolled hyper-proliferation of keratinocytes, disturbed apoptosis, over-secretion of inflammatory cytokines and angiogenic factors. We have developed a novel aqueous polyherbal formulation (SIRB-001) consisting of 3 herbs; Rheum palmatum L. Read More

    The proteasome maturation protein POMP increases proteasome assembly and activity in psoriatic lesional skin.
    J Dermatol Sci 2017 Apr 30. Epub 2017 Apr 30.
    Institut des Biomolécules Max Mousseron (IBMM), CNRS UMR5247, Université de Montpellier, Montpellier, France; Service de Dermatologie, Centre Hospitalier Universitaire de Nîmes, Nîmes, France. Electronic address:
    Background: The ubiquitin proteasome pathway is involved in the pathogenesis of psoriasis and proteasome subunits are increased in lesional psoriatic skin. Recent works have highlighted that proteasome levels can be regulated through modulation of proteasome assembly notably by the proteasome maturation protein POMP.

    Objectives: To investigate whether proteasome assembly and POMP expression are modified in psoriatic skin. Read More

    Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.
    MAbs 2017 Jul 20. Epub 2017 Jul 20.
    a Boehringer Ingelheim Pharmaceuticals Inc. , 900 Ridgebury Rd, Ridgefield , CT. , USA.
    Deficiency of interleukin (IL)-36 receptor antagonist (DITRA) syndrome is a rare autosomal recessive disease caused by mutations in IL36RN. IL-36R is a cell surface receptor and a member of the IL1R family that is involved in inflammatory responses triggered in skin and other epithelial tissues. Accumulating evidence suggests that IL-36R signaling may play a role in the pathogenesis of psoriasis. Read More

    Custom-made micro applicators for high-dose-rate brachytherapy treatment of chronic psoriasis.
    J Contemp Brachytherapy 2017 Jun 13;9(3):263-269. Epub 2017 Jun 13.
    Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, USA.
    Purpose: In this study, we present the treatment of the psoriatic nail beds of patients refractory to standard therapies using high-dose-rate (HDR) brachytherapy. The custom-made micro applicators (CMMA) were designed and constructed for radiation dose delivery to small curvy targets with complicated topology. The role of the HDR brachytherapy treatment was to stimulate the T cells for an increased immune response. Read More

    Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial.
    PLoS One 2017 19;12(7):e0180762. Epub 2017 Jul 19.
    Kineta Inc., Seattle, WA, United States of America.
    Background: Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression and function of Kv1. Read More

    Epidemiology of autoimmune and inflammatory diseases in a French Nationwide HIV cohort.
    AIDS 2017 Jul 18. Epub 2017 Jul 18.
    aDepartment of Internal Medicine, Clinical Immunology and Infectious Diseases, Robert Debré Hospital, University Hospital, Reims, France bDepartment of Internal Medicine and Infectious Diseases, Manchester Hospital, Charleville-Mézières, France cINSERM, UMR 1027, Toulouse III University, CHU Toulouse, COREVIH Toulouse, Toulouse, France dLe Trait d'Union, Centre de Soins de l'Infection par le VIH, Nouvel Hôpital Civil, University Hospital, Strasbourg, France eDepartment of Infectious Diseases, Bichat-Claude Bernard Hospital, APHP, Paris, France fDepartment of Infectious Diseases, Croix-Rousse Hospital, Hospices Civils de Lyon, and INSERM U1052, Lyon, France gDepartment of Infectious Diseases, Hôtel Dieu, Nantes, France hDepartment of Infectious Diseases, University Hospital, Archet Hospital, Nice, France iReims Champagne-Ardenne University, EA-4684 / SFR CAP-SANTE, Reims, F-51095.
    HIV infection and inflammatory and autoimmune diseases (IAD) are both related to immune dysfunction. Epidemiological data on IAD in patients living with HIV (PLHIV) are scarce. The aim of this study was thus to estimate the prevalence of 26 IAD among PLHIV followed in a large French multicenter cohort in the cART era (from January 2000 to July 2013), and to describe their occurrence according to cART onset, the immuno-virological status of patients and HCV and/or HBV co-infection. Read More

    [Diseases affecting the scalp].
    Cas Lek Cesk 2017 ;156(3):137-140
    The skin of the scalp differs from the skin on the other areas of the body because of a higher density of hair follicles and higher sebum production. These, together with the presence of hair, provide a suitable environment for superficial infections, infestations and inflammatory diseases. The good condition of the scalp has a significant impact on the patient's mental well-being and social interaction. Read More

    [Psoriasis comorbidities].
    Cas Lek Cesk 2017 ;156(3):119-122
    Psoriasis is a chronic inflammatory skin disease affecting 2-4 % of Central European population. Nowadays, we know that psoriasis is not limited to the skin but is connected with several comorbidities like, psoriatic arthritis (around 25 %), Crohn's disease, ulcerative colitis, Bechterev, non-alcoholic liver steatosis, psychiatric disorders and mainly diseases of the so called metabolic syndrome, like diabetes mellitus type 2, arterial hypertension or dyslipidemia. In the last years, new information is arising which connect psoriasis with sleep apnoe and chronic obstructive pulmonary disease. Read More

    Reporting of outcomes in randomised controlled trials on nail psoriasis; a Systematic Review.
    Br J Dermatol 2017 Jul 19. Epub 2017 Jul 19.
    Department of Dermatology, Academic Medical Center, Amsterdam, The Netherlands.
    Harmonization of outcome measures is needed to increase the value of clinical trials on nail psoriasis. To provide the first step in core outcome set (COS) development, a systematic review was conducted to identify outcome domains and instruments reported in (ongoing) randomised controlled trials (RCTs) on nail psoriasis. Identified outcome domains included clinical signs, quality of life, symptoms and delivery of care. Read More

    Risk of Cancer in Patients with Psoriasis on Biologic Therapies: A Systematic Review.
    Br J Dermatol 2017 Jul 19. Epub 2017 Jul 19.
    St John's Institute of Dermatology. Guy's and St Thomas' NHS Foundation Trust, London, UK.
    Biologic therapies are highly effective in psoriasis, but have profound effects on innate and adaptive immune pathways that may negatively impact on cancer immunosurveillance mechanisms. To investigate the risk of cancer in psoriasis patients treated with biologic therapy we searched Medline, Embase, and the Cochrane Library (up to August 2016) for randomized control trials, prospective cohort studies and systematic reviews that reported cancer incidence in people exposed to biologic therapy for psoriasis compared to a control population. Eight prospective cohort studies met our inclusion criteria. Read More

    Changes in IL-17A, macrophage-derived chemokine and adiponectin following treatment of psoriasis with calcipotriol plus betamethasone dipropionate aerosol foam: results from the PSO-ABLE study.
    Br J Dermatol 2017 Jul 19. Epub 2017 Jul 19.
    Paul Sabatier University and Larrey Hospital, Toulouse, France.
    Psoriasis vulgaris is an immune-mediated disease characterized by skin and systemic inflammation that is associated with an increased risk of comorbidities such as cardiovascular disease. Although typically associated with moderate-to-severe psoriasis, recent data suggests that increased vascular inflammation may occur in patients with milder psoriasis. It has been shown that systemic treatment of psoriasis leads to an improvement in cardiovascular-associated biomarkers, eg adiponectin levels. Read More

    Obesity and inflammation: the linking mechanism and the complications.
    Arch Med Sci 2017 Jun 31;13(4):851-863. Epub 2016 Mar 31.
    Faculty of Public Health, Al Quds University of Gaza, Palestine.
    Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. Read More

    An update on psoriasis and metabolic syndrome: A meta-analysis of observational studies.
    PLoS One 2017 18;12(7):e0181039. Epub 2017 Jul 18.
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
    The relationship between psoriasis and metabolic syndrome is not well understood. Though multiple epidemiologic studies have suggested a link between psoriasis and metabolic syndrome, there is a lack of a comprehensive meta-analysis synthesizing the results of all available observational studies to date. In this meta-analysis, we examined global data on the relationship between psoriasis and odds of metabolic syndrome by searching for studies published between 1946-2016. Read More

    Exposure to biologic therapies during conception and pregnancy: a systematic review.
    Br J Dermatol 2017 Jul 18. Epub 2017 Jul 18.
    St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK.
    Biologic therapies are effective treatments for psoriasis and are often used in women of childbearing age. To evaluate the safety of biologic therapy in conception and/or pregnancy, we have performed a systematic review of Pubmed, MEDLINE, EMBASE and Cochrane databases for multivariable adjusted studies of women exposed to biologic therapy relevant to the treatment of psoriasis during conception and/or pregnancy. We identified four population-based cohort studies involving 1300 women exposed to TNF-α inhibitors (TNFi) 3 months prior to or during the first 3 months of pregnancy. Read More

    Understanding the phenotypic similarities between IFAP and Olmsted syndrome from a molecular perspective: the interaction of MBTPS2 and TRPV3.
    Arch Dermatol Res 2017 Jul 17. Epub 2017 Jul 17.
    Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
    Ichthyosis Follicularis, Atrichia, and Photophobia (IFAP) is a severe rare genetic disorder caused by mutations in the gene encoding the Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2). Olmsted syndrome is another rare genetic disease with overlapping clinical features caused by mutations in the gene encoding the Transient Receptor Potential Cation Channel, subfamily V (TRPV3). Mutations in MBTPS2 have been recently reported in Olmsted syndrome, underscoring the overlap and the confusion in separating Olmsted from IFAP syndrome. Read More

    Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial.
    J Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    Probity Medical Research and K. Papp Clinical Research Inc., Waterloo, Ontario, Canada.
    Tofacitinib is an oral Janus kinase inhibitor. These post-hoc analyses assessed tofacitinib efficacy and safety in Japanese patients with psoriasis enrolled in a 52-week global phase 3 study. Patients received tofacitinib 5 mg, tofacitinib 10 mg or placebo twice daily (b. Read More

    Activation of the HMGB1‑TLR4‑NF‑κB pathway may occur in patients with atopic eczema.
    Mol Med Rep 2017 Sep 6;16(3):2714-2720. Epub 2017 Jul 6.
    Department of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P.R. China.
    High mobility group protein B1 (HMGB1) has been reported to serve important roles in various pathological conditions. Toll‑like receptor 4 (TLR4), as one of the HMGB1 receptors, has been reported to be involved in the development of certain inflammatory diseases by activating nuclear factor NF‑κ‑B (NF‑κB). However, there are few studies investigating the effects of HMGB1, TLR4 and NF‑κB on human inflammatory dermatoses. Read More

    [Increased expressions of substance P and neurokinin/tachykinin receptor 1 in eosinophils of patients with psoriasis].
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2017 Jul;33(7):966-970
    Allergy and Clinical Immunology Research Centre, First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China. *Corresponding author, E-mail:
    Objective To investigate the expressions of substance P (SP) and its receptor neurokinin/tachykinin receptor 1 (NK1R) in peripheral blood eosinophils of patients with psoriasis. Methods The levels of SP and NK1R in the peripheral blood of both patients with psoriasis and healthy people were detected by flow cytometry. This method was again used to detect the levels of SP and NK1R in the peripheral blood eosinophils of patients with psoriasis after stimulated with the crude extracts of Artemisia pollen, dust mite and Platanus pollen (all at concentrations of 0. Read More

    [Inhibitory effect of bispecific antibody targeting IL-12 p40 and TNF-α simultaneously on psoriasis in mice].
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2017 Jul;33(7):890-895
    China-American Cancer Research Institute, Guangdong Medical University, Dongguan 523080, China. *Corresponding author, E-mail:
    Objective To construct bispecific antibodies, which can block interleukin 12 (IL-12)/IL-23 p40 subunit and tumor necrosis factor α (TNF-α) simultaneously, and identify their biological function and inhibitory effect on psoriasis formation in mice. Methods Based on the sequences of adalimumab and ustekinumab, three kinds of bispecific antibodies were designed, named BiAU003, BiAU022 and BiAU023. The specificity and binding capacity of bispecific antibodies were determined by ELISA. Read More

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