47,937 results match your criteria Psoriasis


Hydrochlorothiazide-Induced Photosensitivity in a Psoriasis Patient Following Exposure to Narrow-Band UVB Excimer Therapy.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

Research Department, Moy-Fincher-Chipps Facial Plastics & Dermatology, 421 N. Rodeo Dr. #T-7, Beverly Hills, CA, 90210.

Drug-induced photosensitivity develops when use of oral or topical photosensitizing medications creates a rash after exposure to ultraviolet radiation. Medications most commonly implicated in photosensitive-drug reactions include amiodarone, nonsteroidal anti-inflammatories, thiazides, tetracycline antibiotics, chlorpromazine, and fluoroquinolones. It is generally believed that drug-induced photosensitivity is an ultraviolet A phenomenon, caused by ultraviolet wavelengths between 315 and 400 nanometers. Read More

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http://dx.doi.org/10.1111/phpp.12471DOI Listing

Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry.

BMJ Open 2019 Apr 20;9(4):e027535. Epub 2019 Apr 20.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.

Objectives: This analysis examined the association between psoriasis severity, assessed by body surface area (BSA) and the Investigator's Global Assessment (IGA; previously used only in clinical trials), and patient-reported outcomes (PROs) in a real-world setting.

Design: Cross-sectional analysis within the Corrona Psoriasis Registry, an independent, prospective registry.

Setting: 70 dermatology practices in the USA. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027535DOI Listing

CD30L/CD30 protects against psoriasiform skin inflammation by suppressing Th17-related cytokine production by Vγ4 γδ T cells.

J Autoimmun 2019 Apr 18. Epub 2019 Apr 18.

Department of Immunology, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, PR China. Electronic address:

Psoriasis is a common, autoimmune, chronic inflammatory skin disease. It has been demonstrated that cutaneous T17 cells play an important pro-inflammatory role in the pathogenesis of psoriasis, through the production of various Th17-related cytokines. Our previous studies have demonstrated that CD30L/CD30 signal plays a pivotal role in the differentiation of CD4 Th17 cells and Vγ6γδ T17 cells in the gut-associated lymphoid tissues of mouse. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.009DOI Listing

Geographic Tongue: What a Dermatologist Should Know.

Actas Dermosifiliogr 2019 Apr 17. Epub 2019 Apr 17.

Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.

Geographic tongue, also known as benign migratory glossitis, is a benign chronic inflammatory condition of the tongue. It is characterized by erythematous lesions with filiform papillae atrophy, surrounded by white limited areas in the dorsal and lateral aspects of the tongue, producing a map-like aspect. This lesions change in size and shape with time, and are characterized by periods of exacerbation and remission without scaring. Read More

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http://dx.doi.org/10.1016/j.ad.2018.10.022DOI Listing

The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells.

Phytomedicine 2019 Feb 26;58:152879. Epub 2019 Feb 26.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan, Taiwan, ROC; Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. Electronic address:

Background: Anti-angiogenesis is an important strategy of psoriasis treatment, but the side effects of systemic agents remain difficult to overcome. Topical use of indigo naturalis ointment has been proved to improve the skin lesion of psoriasis effectively and safely and one of its major components, tryptanthrin, has been demonstrated to have anti-angiogenic effect. Apelin, which has been reported to act as an angiogenic factor that could stimulate the proliferation and migration of vascular endothelial cells and proved to be elevated in psoriasis patients, is a potential target of anti-angiogenic therapy. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.152879DOI Listing
February 2019

Nanoemulsion strategy of pioglitazone for the treatment of skin inflammatory diseases.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.017DOI Listing
April 2019
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The impact of recent advances in lipidomics and redox lipidomics on dermatological research.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Medical University of Vienna, Austria; Christian Doppler Laboratory for the Biotechnology of Skin Aging, Vienna, Austria.

Dermatological research is a major beneficiary of the rapidly developing advances in lipid analytic technology and of bioinformatic tools which help to decipher and interpret the accumulating big lipid data. At its interface with the environment, the epidermis develops a blend of lipids that constitutes the epidermal lipid barrier, essential for the protection from water loss and entry of dangerous noxae. Apart from their structural role in the barrier, novel intra- and inter-cellular signaling functions of lipids and their oxidation products have been uncovered in most cutaneous cell types over the last decades, and the discovery rate has been boosted by the advent of high resolution and -throughput mass spectrometric techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849193015
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.019DOI Listing
April 2019
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Rostrum: Itching as a systemic disease.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center Miller School of Medicine University of Miami, Miami, FL. Electronic address:

Pruritus is a sensation that emanates from the skin and is transferred via peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders such as atopic eczema, skin dryness, psoriasis, and urticaria can elicit pruritus. However certain systemic diseases can cause chronic pruritus that have significant impact on patients' quality of life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193052
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http://dx.doi.org/10.1016/j.jaci.2019.04.005DOI Listing
April 2019
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Clinical response correlates with 4-week post injection ustekinumab concentrations in moderate-to-severe psoriasis patients.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

Background: Cost-effective use of biologicals is becoming increasingly important. Monitoring drug concentrations has emerged as a valuable tool to guide clinical decision-making as drug concentrations have been linked to clinical outcomes. The presence of a concentration-response relationship for ustekinumab at trough is uncertain due to the contradictory results reported. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18016
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http://dx.doi.org/10.1111/bjd.18016DOI Listing
April 2019
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Efficacy of secukinumab without the initial weekly loading dose in patients with chronic plaque psoriasis.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Background: Secukinumab is administered at the labelled dose of 300 mg at weeks 0, 1, 2, 3, 4 (loading dose) and every 4 weeks thereafter.

Objective: To investigate the efficacy of secukinumab administered without the initial loading dose in patients with psoriasis.

Materials And Methods: a retrospective, observational study including adult patients with psoriasis (n=156) treated with secukinumab 300 mg administered either according to the labelled dose (n=75) or without the initial loading dose (n=81). Read More

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http://dx.doi.org/10.1111/bjd.18015DOI Listing

Pro- and anti-inflammatory eicosanoids in psoriatic arthritis.

Metabolomics 2019 Apr 19;15(4):65. Epub 2019 Apr 19.

Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.

Introduction: Eicosanoids are biological lipids that serve as both activators and suppressors of inflammation. Eicosanoid pathways are implicated in synovitis and joint destruction in inflammatory arthritis, yet they might also have a protective function, underscoring the need for a comprehensive understanding of how eicosanoid pathways might be imbalanced. Until recently, sensitive and scalable methods for detecting and quantifying a high number of eicosanoids have not been available. Read More

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http://dx.doi.org/10.1007/s11306-019-1527-0DOI Listing

Factors predicting pruritus in psoriasis.

Presse Med 2019 Apr 16. Epub 2019 Apr 16.

Ibn Sina Hospital, Dermatology Department, 10000 Rabat, Morocco.

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http://dx.doi.org/10.1016/j.lpm.2019.02.016DOI Listing

Can we better strategize our choice of pharmacotherapy for patients with co-morbid psoriasis and obesity?

Expert Opin Pharmacother 2019 Apr 19:1-6. Epub 2019 Apr 19.

b 2nd Department of Dermatology and Venereal Diseases , Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens , Athens , Greece.

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http://dx.doi.org/10.1080/14656566.2019.1603294DOI Listing

Nonvascular uses of pulsed dye laser in clinical dermatology.

J Cosmet Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Lasers are fast becoming the vogue of dermatology ranging from ablative, nonablative, fractional photothermolysis to vascular lasers. There are a range of vascular lasers including potassium titanyl phosphate (KTP 532 nm), pulsed dye laser (PDL -595 nm), diode (810 nm), and Nd:YAG (1064 nm). PDL is a laser that emits yellow light using Rhodamine dye as it is lasing medium. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12924
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http://dx.doi.org/10.1111/jocd.12924DOI Listing
April 2019
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Squamous cell carcinoma-related antigen 2 level is a reliable indicator of severe psoriasis involving the face.

G Ital Dermatol Venereol 2019 Jun;154(3):374-375

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China -

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http://dx.doi.org/10.23736/S0392-0488.17.05738-8DOI Listing

Moderate-to-severe psoriasis and pregnancy: impact on fertility, pregnancy outcome and treatment perspectives.

G Ital Dermatol Venereol 2019 Jun;154(3):305-314

Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Psoriasis affects 2-4% of the world's population, with no difference between men and women and 70% of patients experiencing disease onset before the age of 40, which coincides with the reproductive years. Few data are available from literature on impact of psoriasis on fertility, course and outcome of pregnancy and risk associated with treatments. Recent studies on other immune-mediated inflammatory diseases, among which psoriasis is also included, indicate that rheumatoid arthritis and inflammatory bowel diseases can impact female fertility and pregnancy outcomes especially during active disease episodes. Read More

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https://www.minervamedica.it/index2.php?show=R23Y2019N03A030
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http://dx.doi.org/10.23736/S0392-0488.18.06255-7DOI Listing
June 2019
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Efficacy of ixekizumab in patients with resistance or incomplete response to secukinumab.

J Eur Acad Dermatol Venereol 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, Toulouse University, Hôpital Larrey, Toulouse, France.

Clinical studies have the shown rapid efficacy biological agents targeting anti-IL17 in patients with moderate to severe plaque psoriasis. However, preliminary data from the Danish registry DERMBIO showed a significant loss of efficacy with secukinumab. This was a retrospective study of 14 patients treated with secukinumab for moderate-to-severe psoriasis who had an incomplete initial response or who experienced a loss of efficacy with secukinumab and who were subsequently treated with ixekizumab. Read More

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http://dx.doi.org/10.1111/jdv.15630DOI Listing

Old is gold? Retrospective evaluation of efficacy and safety of topical psoralen-UVA phototherapy for palmoplantar psoriasis and dermatitis.

Br J Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Photomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

Over the last decade new systemic drugs (e.g. biologics, apremilast, alitretinoin) have diversified the options for treating palmoplantar dermatoses such as psoriasis and dermatitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18012
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http://dx.doi.org/10.1111/bjd.18012DOI Listing
April 2019
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Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate to severe plaque-type psoriasis: Results from extension phase of the SUPREME study.

Br J Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Dermatology Unit, Department of Biomedical Sciences, Humanitas University, Via Alessandro Manzoni 113, 20089, Rozzano-Milan, Italy.

Recent studies have shown that biological drugs approved for treating psoriasis and psoriatic arthritis are not effective in all patients, and that variations in the genome have been associated with different clinical responses or side effects. HLA-Cw6 gene is associated with more severe and early-onset psoriasis. Recent reports have shown that HLA-Cw6 status predicts efficacy of some biologic treatments in psoriasis patients. Read More

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http://dx.doi.org/10.1111/bjd.18013DOI Listing

Concordance between the Different Cardiovascular Risk Scores in People with Rheumatoid Arthritis and Psoriasis Arthritis.

Cardiol Res Pract 2019 14;2019:7689208. Epub 2019 Mar 14.

Clinical Epidemiology and Biostatistics Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña, Hotel de Pacientes 7 Planta, C/As Xubias de Arriba, 84, 15006 A Coruña, Spain.

Aim: To determine the cardiovascular risk and the concordance between the different scores in people with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).

Methods: Observational descriptive study of prevalence. Performed in the Rheumatology Service and the Clinical Epidemiology and Biostatistics Unit of the University Hospital Complex of A Coruña (Spain). Read More

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http://dx.doi.org/10.1155/2019/7689208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437736PMC

The IL-23/IL-17 pathway in human chronic inflammatory diseases-new insight from genetics and targeted therapies.

Genes Immun 2019 Apr 19. Epub 2019 Apr 19.

Immunoregulation Unit, Department of Immunology, Institut Pasteur, Paris, France.

Chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, spondyloarthritis, and psoriasis cause significant morbidity and are a considerable burden for the patients in terms of pain, impaired function, and diminished quality of life, as well as for society, because of the associated high health-care costs and loss of productivity. Our limited understanding of the pathogenic mechanisms involved in these diseases currently hinders early diagnosis and the development of more specific and effective therapies. The past years have been marked by considerable progress in our insight of the genetic basis of many diseases. Read More

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http://www.nature.com/articles/s41435-019-0067-y
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http://dx.doi.org/10.1038/s41435-019-0067-yDOI Listing
April 2019
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Goeckerman Therapy of Psoriasis: Genotoxicity, Dietary Micronutrients, Homocysteine, and Gene Polymorphisms.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University, 50003 Hradec Kralove, Czech Republic.

Goeckerman therapy (GT) of psoriasis vulgaris is based on the application of crude coal tar and ultraviolet radiation. We investigated DNA damage by the number of micronucleated binucleated cells (MNBC) in lymphocytes, serum homocysteine, vitamin B12, folic acid, and two polymorphisms (C677T and A1298C) in the gene in 35 patients with exacerbated psoriasis vulgaris classified according to the psoriasis area and severity index (PASI) score and treated by GT. The median of PASI score decreased from nineteen to five, and MNBC increased from 10 to 18‰ after GT ( < 0. Read More

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http://dx.doi.org/10.3390/ijms20081908DOI Listing

IL-17-high asthma with features of a psoriasis immunophenotype.

J Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Respiratory, Inflammation, Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Background: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required.

Objective: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity.

Methods: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193048
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http://dx.doi.org/10.1016/j.jaci.2019.03.027DOI Listing
April 2019
2 Reads

Dysregulation of Akt-FOXO1 pathway leads to dysfunction of regulatory T cells in psoriasis patients.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Psoriasis is a T lymphocyte-driven systemic inflammatory disease. Regulatory T (Treg) cells are essential for establishing and maintaining immune tolerance. In this study, we found that the psoriatic patients and healthy controls had comparable percentages of circulating CD4CD25FOXP3 Treg cells, but psoriatic Treg cells had reduced suppressive function. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.035DOI Listing

Lp- PLA2 as a promising predictor of comorbidities in patients with severe psoriasis.

J Dermatolog Treat 2019 Apr 18:1-27. Epub 2019 Apr 18.

a Department of Dermatology and Venereology Medical University of Bialystok , 15-540 Bialystok, Zurawia 14 St , Poland.

Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well- known risk factor of atherosclerotic vascular diseases which are common comorbidities in psoriasis. The aim of this study was to evaluate serum Lp-PLA2 level in psoriatic patients and elucidate possible associations with disease activity, metabolic or inflammatory parameters and systemic treatment.

Methods: We enrolled 33 patients with active plaque-type psoriasis and 11 healthy controls. Read More

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http://dx.doi.org/10.1080/09546634.2019.1606887DOI Listing

A case of Generalized Pustular Psoriasis and arthritis treated with ixekizumab.

J Dermatolog Treat 2019 Apr 18:1-7. Epub 2019 Apr 18.

a Department of Dermatology , Univeristy of Rome "Tor Vergata" , Rome , Italy.

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http://dx.doi.org/10.1080/09546634.2019.1606395DOI Listing

Heat shock proteins and psoriasis.

Eur J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaArticle accepted on October 23, 2018.

Psoriasis is a chronic disfiguring skin condition which may be induced or exacerbated by stress. Heat shock proteins (HSPs), as molecular chaperones, play a central role in protein folding and cellular protein homeostasis. The many different functions of HSPs in the cell depend on the specific HSP involved. Read More

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http://dx.doi.org/10.1684/ejd.2019.3526DOI Listing
April 2019
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Assessment of cardiac and vessel functions in childhood psoriasis

Turk J Med Sci 2019 Apr 18;49(2):617-623. Epub 2019 Apr 18.

Background/aim: Psoriasis is a chronic inflammatory disease. The effect of psoriasis on the cardiovascular system has not been studied in children before. We studied ventricular strain and vascular functions to assess early cardiovascular effects of psoriasis during childhood. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1812-139DOI Listing
April 2019
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The efficacy and safety of targeted narrowband UVB therapy: a retrospective cohort study

Turk J Med Sci 2019 Apr 18;49(2):595-603. Epub 2019 Apr 18.

Background/aim: Phototherapy is a safe and effective treatment modality for numerous dermatological conditions. Recently, targeted phototherapy modalities have gained importance due to their advantages over conventional phototherapy.This retrospective study aimed to evaluate the safety and efficacy of targeted narrowband UVB phototherapy in patients with dermatological disorders

Materials And Methods: This single-center study included 173 patients who were treated with targeted narrowband UVB phototherapy. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1810-110DOI Listing
April 2019
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Systemic Sclerosis is Linked to Psoriasis and May Impact on Patients' Survival: A Large Cohort Study.

J Clin Med 2019 Apr 16;8(4). Epub 2019 Apr 16.

Department of Medicine B and Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat-Gan 5265601, Israel.

Although skin manifestations are quite common in systemic sclerosis (SSc), a link between SSc and psoriasis (PsO) has been poorly investigated. We assessed the Clalit medical database in a cohort study to compare the prevalence of PsO between SSc-patients and SSc-free controls. We also evaluated the SSc-related autoantibodies' role in the co-existence of the two conditions. Read More

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http://dx.doi.org/10.3390/jcm8040521DOI Listing

IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

Cell Rep 2019 Apr;27(3):835-846.e5

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. Electronic address:

Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193042
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http://dx.doi.org/10.1016/j.celrep.2019.03.082DOI Listing
April 2019
2 Reads

Tissue lipocalin-2 in psoriasis: Is it a marker of metabolic disturbance or a possible marker of therapeutic efficacy after narrow band ultraviolet B?

J Dermatolog Treat 2019 Apr 17:1-20. Epub 2019 Apr 17.

a Dermatology Department, Faculty of Medicine , Cairo University , Egypt.

Background: Lipocalin-2 (LCN2) is an adipokine related to insulin resistance and metabolic syndrome (MetS) in addition to its role in innate immunity and apoptosis.

Objective: To estimate LCN2 tissue levels (lesional and non-lesional) in psoriasis. To assess the metabolic status of patients and to detect any possible associations between LCN2 and MetS. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1605141DOI Listing
April 2019
2 Reads

Comparative Overall Comorbidity Burden Among Patients With Hidradenitis Suppurativa.

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

Importance: The overall comorbidity burden among patients with hidradenitis suppurativa (HS) has not been systematically evaluated.

Objectives: To investigate the standardized overall comorbidity burden among patients with HS and to compare it with the comorbidity burden in patients with psoriasis and a control group.

Design, Setting, And Participants: A cross-sectional analysis was conducted of 5306 patients with HS, 14 037 patients with psoriasis, and 1 733 810 controls identified using electronic health records data from October 1, 2013, through October 1, 2018. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2019.0164DOI Listing
April 2019
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Association of HLA-C*06:02 Status With Differential Response to Ustekinumab in Patients With Psoriasis: A Systematic Review and Meta-analysis.

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Radboud University Medical Centre, Radboud Institute of Health Sciences, Nijmegen, the Netherlands.

Importance: Previous research showed a differential response to ustekinumab therapy based on HLA-C*06:02 status in patients with psoriasis but consisted mostly of small (and sometimes inconclusive) cohort studies.

Objective: To assess whether HLA-C*06:02 status is associated with a differential response to ustekinumab therapy in patients with psoriasis through a systematic review and a meta-analysis of available data.

Data Sources: A comprehensive search was conducted using MEDLINE, Embase, the Cochrane Library, Web of Science, and gray literature sources. Read More

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http://dx.doi.org/10.1001/jamadermatol.2019.0098DOI Listing

The gut and the Inflammatory Bowel Diseases inside-out: the extra-intestinal manifestations.

Minerva Gastroenterol Dietol 2019 Apr 16. Epub 2019 Apr 16.

The Medical Center Practice Office, Turin, Italy.

An increasing deal of attention is being conveyed on the extra-intestinal manifestations of inflammatory bowel diseases (IBD). We compiled the present review in an attempt to upgrade the accuracy of the classification of such polymorphic entities. We focused on three patterns. Read More

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http://dx.doi.org/10.23736/S1121-421X.19.02577-7DOI Listing
April 2019
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Drug survival and reasons for drug discontinuation in palmoplantar pustulosis: a retrospective multicenter study.

J Dtsch Dermatol Ges 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Georg-August-University Göttingen, Göttingen, Germany.

Background: Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease-related to psoriasis. Its treatment is challenging, and little is known about the sustainability of different medications. The aim of this study was to analyze drug survival rates and drug discontinuation in the treatment of PPP under real-world conditions. Read More

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http://dx.doi.org/10.1111/ddg.13834DOI Listing
April 2019
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Vitiligo in a patient receiving infliximab for chronic plaque psoriasis.

Dermatol Ther 2019 Apr 17:e12917. Epub 2019 Apr 17.

Department of Dermatology, Shanghai Skin Disease Hospital, 1278 Baode Road, Shanghai 200443, China.

Infliximab is a TNF-a Inhibitor widely used in the treatment of moderate to severe chronic plaque psoriasis. Here, we report a case of vitiligo following infliximab administration in a patient with chronic plaque psoriasis. The case serves as a reminder of vitiligo induced by TNF-a-antagonist therapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12917
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http://dx.doi.org/10.1111/dth.12917DOI Listing
April 2019
3 Reads

Hand-foot-and-mouth-disease-induced Koebner phenomenon in psoriasis.

J Dtsch Dermatol Ges 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13824
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http://dx.doi.org/10.1111/ddg.13824DOI Listing
April 2019
1 Read

Liver fatty acid-binding protein might be a predictive marker of clinical response to systemic treatment in psoriasis.

Arch Dermatol Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540, Białystok, Poland.

Fatty acid-binding proteins play an inconclusive role in lipid metabolism and cardiometabolic diseases (CMDs) which are closely related with psoriasis. Aim of the study was to investigate the diagnostic value of serum liver fatty acid-binding protein (FABP1) level and associations with disease severity, inflammation or metabolic parameters and influence of systemic treatment in psoriatic patients. The study included thirty-three patients with active plaque-type psoriasis and eleven healthy volunteers. Read More

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http://dx.doi.org/10.1007/s00403-019-01917-wDOI Listing
April 2019
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A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars.

Clin Ter 2019 Mar-Apr;170(2):e93-e99

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena - Second Opinion Medical Network, Modena (MO), Italy.

Objective: To investigate the therapeutic effect of CBD-ointment administered on severe skin chronic diseases and/or on their outcome scars.

Methods: A spontaneous, anecdotal, retrospective study of 20 patients with two most frequent skin disorders: psoriasis (n: 5 patients), atopic dermatitis (n: 5) and resulting outcome scars (n: 10). The subjects were instructed to administer topical CBD-enriched ointment to lesioned skin areas twice daily for three months treatment. Read More

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http://dx.doi.org/10.7417/CT.2019.2116DOI Listing
April 2019
2 Reads

Real-life effectiveness of ustekinumab in inflammatory bowel disease patients with concomitant psoriasis or psoriatic arthritis: An IG-IBD study.

Dig Liver Dis 2019 Apr 13. Epub 2019 Apr 13.

IBD Unit, Presidio Columbus, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:

Background: Few data exist regarding the effectiveness of ustekinumab in inflammatory bowel disease (IBD) patients treated for concomitant psoriasis or psoriatic arthritis.

Aims: to describe the outcomes of IBD patients who received subcutaneous ustekinumab through a dermatological or rheumatological prescription.

Methods: This multicenter, retrospective study included all IBD patients who were started on ustekinumab for concomitant active psoriasis/ psoriatic arthritis, irrespective of IBD activity. Read More

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http://dx.doi.org/10.1016/j.dld.2019.03.007DOI Listing
April 2019
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Off-Label High-Dose Secukinumab for the Treatment of Moderate-to-Severe Psoriasis.

J Cutan Med Surg 2019 Apr 16:1203475419843118. Epub 2019 Apr 16.

7 Division of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Secukinumab is an anti-IL-17A monoclonal antibody approved for the treatment of moderate-to-severe psoriasis in adult patients. Despite its favourable safety and efficacy profile in clinical trials, some patients in clinical practice fail to respond adequately to the approved maintenance regimen of 300 mg subcutaneous monthly. Some clinicians manage these patients by using off-label high-dose secukinumab regimens, which include shortening the dosing interval to 300 mg every 2 or 3 weeks instead of monthly, or increasing the monthly dose to 450 mg. Read More

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http://dx.doi.org/10.1177/1203475419843118DOI Listing
April 2019
7 Reads

Translational drug discovery and development with the use of tissue-relevant biomarkers: towards more physiological relevance and better prediction of clinical efficacy.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Sanofi, Global Head of Immunology Therapeutic Research Area, 640 Memorial Drive, Cambridge, MA, 02139, USA.

Due to the clinical development of drugs such as secukinumab, ustekinumab and dupilumab, major changes have been achieved in the treatment of patients diagnosed with psoriasis and atopic dermatitis. In academia and the pharmaceutical industry, research is increasingly moving towards the development of bi-specific antibodies and multi-specific nanobodies, as there is a compelling need for new treatment modalities for patients suffering from auto-immune or malignant disease. The purpose of this review is to discuss aspects of translational drug development with a particular emphasis on indications such as psoriasis and atopic dermatitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13942
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http://dx.doi.org/10.1111/exd.13942DOI Listing
April 2019
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Automatic Scale Severity Assessment Method in Psoriasis Skin Images using Local Descriptors.

IEEE J Biomed Health Inform 2019 Apr 15. Epub 2019 Apr 15.

Psoriasis is a chronic skin condition. Its clinical assessment involves four measures: erythema, scales, induration and area. In this paper, we introduce a scale severity scoring framework for two-dimensional psoriasis skin images. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2910883DOI Listing

[Virtual screening study of cathepsin S natural inhibitor].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1201-1207

Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Peking Union Medical College Beijing 100193,China.

Cathepsin S is a cysteine protease which is closely related to autoimmune diseases,psoriasis and other diseases. In this study,we used virtual screening method to screen compounds,which from the natural product library of traditional Chinese medicine,with potential inhibitory effect on cathepsin S. The work involved in study on inhibitory mechanism of representative compounds,then analysis of the distribution of these compounds in traditional Chinese medicine and the correlation with disease,so as to provide a new drug research and data-base for cathepsin S. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181226.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181226.017DOI Listing
March 2019
2 Reads

[Analysis of epidemiological characteristics of drug induced liver injury associated with Baixianpi Preparations].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(5):1048-1052

Department of Pharmacy,Dongzhimen Hospital Afliated to Beijing University of Traditional Chinese Medicine Beijing 100700,China.

A retrospective study was performed in drug-induced liver injury(DILI) cases associated with Dictamni Cortex(Baixianpi,BXP) Preparations,which were treated at grade Ⅲ class A liver disease hospitals from 2008 to 2016 and spontaneously reported for adverse reactions between 2012 and 2016 at HILI Cloud(hilicloud.net). The results showed 25 DLII cases associated with BXP Preparations treated at grade Ⅲ class A liver disease hospitals during the 9 years,including only 14 cases in line with the clinical diagnostic criteria of Guidelines for the Diagnosis and Treatment of Herb-Induced Liver Injury. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181217.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181217.001DOI Listing
March 2019
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Mycosis Fungoides with Spongiosis: a Potential Diagnostic Pitfall.

J Cutan Pathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Mayo Clinic Rochester, Minnesota.

Background: Mycosis fungoides (MF) is characterized by epidermotropic atypical lymphocytes in the absence of spongiosis. However , we describe a unique presentation of MF with spongiosis, mimicking benign inflammatory dermatoses and highlight the importance of pathologic interpretation for diagnostic confirmation.

Methods: A cross-sectional study of consecutive patients diagnosed with MF with spongiosis was conducted. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13477
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http://dx.doi.org/10.1111/cup.13477DOI Listing
April 2019
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The role of invariant T cells in inflammation of the skin and airways.

Semin Immunopathol 2019 Apr 15. Epub 2019 Apr 15.

Centre for Cancer Biology, The University of South Australia and SA Pathology, North Terrace, Adelaide, SA, 5000, Australia.

Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells express T cell receptors of very limited diversity. iNKT and MAIT cells recognise antigens presented by the MHC class 1-like monomorphic molecules CD1d and MR1, respectively. Read More

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http://link.springer.com/10.1007/s00281-019-00740-9
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http://dx.doi.org/10.1007/s00281-019-00740-9DOI Listing
April 2019
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The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man.

Inflamm Res 2019 Apr 13. Epub 2019 Apr 13.

Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, UK.

Objective: The heterodimeric IL-12 family member cytokines including, IL-12, IL-23, IL-27, and IL-35 and have multiple roles in regulating innate and adaptive immunity with crucial functions in inflammatory disorders such as psoriasis. Chain pairing promiscuity is a feature of the IL-12 family. Recently, based on murine data, a new family member, IL-39, was proposed, consisting of IL23p19 (shared with IL-23) and EBI3 (shared with IL-27 and IL-35). Read More

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http://link.springer.com/10.1007/s00011-019-01235-x
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http://dx.doi.org/10.1007/s00011-019-01235-xDOI Listing
April 2019
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Peripheral manifestations in spondyloarthritis and their impact: an ancillary analysis of the ASAS-COMOSPA study.

J Rheumatol 2019 Apr 15. Epub 2019 Apr 15.

From the Rheumatology Department, Cochin Hospital, Paris, FRANCE; Inserm (U1153), Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, FRANCE; Department of Medicine, University of Cordoba. Cordoba, SPAIN. The ASAS-COMOSPA study was conducted under the umbrella of ASAS and was financially supported by unrestricted grants from AbbVie, Pfizer and UCB. Conflict of interest. The authors have no conflicts of interest related for this work. Address correspondence to Clementina López-Medina, MD, PhD. Rheumatology Department, Cochin Hospital. 27 rue du Faubourg Saint Jacques, 75014 PARIS, France, E-mail:

Objective: a) to determine the factors associated with the presence of peripheral manifestations in patients with spondyloarthritis (SpA) from the ASAS-COMOSPA study, b) to evaluate the impact of these symptoms on treatment and Patient Reported Outcomes (PROs).

Methods: All patients from the ASAS-COMOSPA study were included. All patients had a SpA diagnosis according to the rheumatologist. Read More

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http://dx.doi.org/10.3899/jrheum.181331DOI Listing