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    Roles of miR-31 and endothelin-1 in psoriasis vulgaris: pathophysiological functions and potential biomarkers.
    Physiol Res 2017 Sep 22. Epub 2017 Sep 22.
    Institute of Pathological Physiology, Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic.
    Psoriatic lesions are characterized by hyperproliferation, aberrant differentiation of keratinocytes resistant to apoptosis and inflammation. miR-31 plays pro-proliferative, pro-differentiative and pro-inflammatory roles and modulates apoptosis in psoriatic keratinocytes. Endothelin 1 (ET-1) is produced by psoriatic keratinocytes and suppresses apoptosis. Read More

    TLR7/8 agonists stimulate plasmacytoid dendritic cells to initiate a Th17-deviated acute contact dermatitis in humans.
    J Allergy Clin Immunol 2017 Sep 18. Epub 2017 Sep 18.
    Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.
    Background: A standardized human model to study early pathogenic events in psoriasis is missing. Activation of Toll-like receptor 7/8 by topical application of imiquimod is the most commonly used mouse model of psoriasis.

    Objective: To investigate the potential of a human imiquimod patch test model to resemble human psoriasis. Read More

    Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study.
    Arthritis Res Ther 2017 Sep 21;19(1):210. Epub 2017 Sep 21.
    Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, UK.
    Background: A recent systematic review identified four candidate serum-soluble bone-turnover biomarkers (dickkopf-1, Dkk-1; macrophage-colony stimulating factor, M-CSF; matrix metalloproteinase-3, MMP-3; osteoprotegerin, OPG) showing possible association with psoriatic arthritis (PsA). We aimed to: (i) confirm and determine if these four biomarkers are associated with PsA; (ii) differentiate psoriasis cases with and without arthritis; and (iii) differentiate PsA cases with and without axial arthritis.

    Methods: A prospective cross-sectional comparative two-centre study recruited 200 patients with psoriasis without arthritis (PsC), 127 with PsA without axial arthritis (pPsA), 117 with PsA with axial arthritis (psoriatic spondyloarthritis, PsSpA), 157 with ankylosing spondylitis (AS) without psoriasis, and 50 matched healthy controls (HC). Read More

    A Case of Inappropriate Self-Medication Compounded with Prescribing vis-à-vis Dispensing Errors and the Hazardous Consequence.
    Curr Drug Saf 2017 Sep 19. Epub 2017 Sep 19.
    Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata. India.
    INTRODUCTION Dispensing error, a type of medication error, is not infrequent but seldom reported. Self-medication behavior appears to be a commonplace. And when it is ignorant it may prove dangerous. Read More

    Effects of secukinumab on serum adipocytokines: preliminary data.
    Reumatismo 2017 Sep 21;69(3):105-110. Epub 2017 Sep 21.
    Unit of Rheumatology, University of Verona.
    Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects joints, connective tissues and the axial skeleton. Metabolic syndrome is an independent risk factor for psoriasis (Pso) development and is associated with more severe forms of Pso. Adipocytokines are secreted by white adipose tissue and are thought to link obesity with the development of metabolic and cardiovascular diseases. Read More

    Probiotics for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Front Cell Infect Microbiol 2017 6;7:392. Epub 2017 Sep 6.
    Department of Dermatology, Xiangya Hospital, Central South UniversityChangsha, China.
    Objective: Atopic dermatitis (AD) is a prevalent, burdensome, and psychologically important pediatric concern. Probiotics have been suggested as a treatment for AD. Some reports have explored this topic; however, the utility of probiotics for AD remains to be firmly established. Read More

    Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis.
    Mediators Inflamm 2017 28;2017:9538451. Epub 2017 Aug 28.
    Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland.
    Purpose: The evaluation of new inflammatory biomarkers in psoriasis could determine therapeutic decisions. Chitinase-3-like protein 1 (YKL-40) plays a role in inflammation. The study was undertaken to check whether YKL-40 is a reliable biomarker of inflammation in psoriasis. Read More

    A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease.
    JCI Insight 2017 Sep 21;2(18). Epub 2017 Sep 21.
    Department of Pathology and Immunology, Division of Immunobiology.
    Dendritic cells (DCs) are important in regulating immunity and tolerance and consist of functionally distinct subsets that differentially regulate T lymphocyte function. The underlying basis for this subset specificity is lacking, particularly in humans, where the classification of tissue DCs is currently incomplete. Examination of healthy human epidermal Langerhans cells and dermal skin cells revealed a tissue CD5-expressing DC subtype. Read More

    Long-term Impact of Ixekizumab on Psoriasis Itch Severity: Results From a Phase III Clinical Trial and Long-term Extension.
    Acta Derm Venereol 2017 Sep 20. Epub 2017 Sep 20.
    Beth Israel Deaconess Hospital and Harvard Medical School, 375 Longwood Ave, Boston, MA 02215, USA.
    Itching is a prevalent plaque psoriasis symptom. Ixekizumab, an IL-17A antagonist, has demonstrated rapid, significant improvements in itch severity over 12 weeks in Phase III psoriasis trials (UNCOVER-1, UNCOVER-2). We assessed the long-term (through 60 weeks) effect of ixekizumab maintenance therapy (80-mg ixekizumab every 4 weeks [IXEQ4W]) on itch severity, using the Itch Numeric Rating Scale, in psoriasis patients who received ixekizumab, placebo, or etanercept for 12 weeks in the Phase III UNCOVER-3 trial. Read More

    GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.
    Sci Rep 2017 Sep 19;7(1):11847. Epub 2017 Sep 19.
    Division of Immunodermatology and Allergy Research, Department for Dermatology, Allergy and Venereology, Hannover Medical School, 30625, Hannover, Germany.
    GATA3 is a transcription factor with an important role in atopic diseases because of its role in the differentiation of Th2 lymphocytes. Moreover, GATA3 is expressed in keratinocytes and has a role in keratinocyte differentiation and the establishment of the epidermal barrier. In this study, we investigated the role of GATA3 in keratinocytes in the context of epidermal barrier integrity under inflammatory skin conditions. Read More

    Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models.
    Sci Rep 2017 Sep 19;7(1):11838. Epub 2017 Sep 19.
    Department of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center (Radboudumc), PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.
    The strong societal urge to reduce the use of experimental animals, and the biological differences between rodent and human skin, have led to the development of alternative models for healthy and diseased human skin. However, the limited availability of primary keratinocytes to generate such models hampers large-scale implementation of skin models in biomedical, toxicological, and pharmaceutical research. Immortalized cell lines may overcome these issues, however, few immortalized human keratinocyte cell lines are available and most do not form a fully stratified epithelium. Read More

    Vascular endothelial growth factor driving aberrant keratin expression pattern contributes to the pathogenesis of psoriasis.
    Exp Cell Res 2017 Sep 16. Epub 2017 Sep 16.
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:
    Psoriasis is a chronic inflammatory skin disease severely affecting patients' physical and psychological well-being. Aberrant keratin expression in psoriasis plays a crucial role in keratinocyte dysfunction and disease development. Little is yet known about the mechanism of this keratin dysregulation. Read More

    CD100-Plexin-B2 promotes the inflammation in psoriasis by activating NF-κB and inflammasome in keratinocytes.
    J Invest Dermatol 2017 Sep 16. Epub 2017 Sep 16.
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:
    Plexin-B2 (PlxnB2) and its ligand, CD100 (Semaphorin 4D), are originally identified as axon-guidance molecules that function during neuronal development; however, studies also showed that CD100-Plexins participate in various immune responses. In the present study, we found that the expression of PlxnB2 on keratinocytes was specifically increased in lesional skin of psoriasis patients, but not atopic dermatitis. Levels of soluble CD100 (sCD100) and membrane CD100 (mCD100) were elevated in sera of psoriasis patients and on keratinocytes of psoriatic skin, respectively. Read More

    Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3.
    J Invest Dermatol 2017 Sep 16. Epub 2017 Sep 16.
    INSERM U1035, BMGIC, Immuno-dermatology ATIP-AVENIR, University of Bordeaux; Department of Dermatology and Pediatric Dermatology; National Reference Center for Rare Skin disorders, Hôpital Saint-André, Bordeaux, France.
    Vitiligo is a chronic auto-immune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (TRM). Read More

    Reduction of inflammatory and cardiovascular proteins in the blood of psoriasis patients; differential responses between tofacitinib and etanercept after 4 weeks of treatment.
    J Invest Dermatol 2017 Sep 16. Epub 2017 Sep 16.
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA. Electronic address:
    Psoriasis patients have increased risk of myocardial infarction, and psoriasis is now recognized as an independent risk factor for coronary heart disease and cardiovascular mortality. To understand the effects of psoriasis medications on systemic inflammation associated with cardiovascular risks, we studied blood proteins related to inflammation and cardiovascular disease archived from a phase 3 clinical trial of tofacitinib and etanercept in adults with moderate-to-severe psoriasis. 157 blood proteins were quantified by a proximity extension assay from 266 patients at baseline and week 4. Read More

    Epidemiology of eczema herpeticum in hospitalized US children: Analysis of a nationwide cohort.
    J Invest Dermatol 2017 Sep 16. Epub 2017 Sep 16.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611. Electronic address:
    Eczema herpeticum (EH) is characterized by viral infection of a preexisting inflammatory dermatosis and is associated with considerable morbidity. In this cross-sectional study, we sought to determine the incidence, risk factors, comorbidities, costs of care, length of stay, and mortality in hospitalized US children with EH. The Nationwide Inpatient Sample 2002-2012, containing a 20% sample of all US hospitalizations, was analyzed. Read More

    Effect of Topical Application of Black Seed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino Rats.
    Anat Rec (Hoboken) 2017 Sep 19. Epub 2017 Sep 19.
    Pharmacology department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
    Psoriasis is a chronic inflammatory skin disease that affects about 1%-3% of the world's population. Black seed oil, i.e. Read More

    Apremilast in psoriasis - a prospective real-world study.
    J Eur Acad Dermatol Venereol 2017 Sep 19. Epub 2017 Sep 19.
    The Rudolfstiftung Hospital, Dermatology, Vienna, Austria.
    Background: Apremilast is a novel oral phosphodiesterase-4 inhibitor approved for psoriasis treatment. Randomized trials have documented its efficacy and safety, but data on real-world patients are scarce.

    Objectives: We aim to characterize psoriasis patients treated with apremilast in a real-world setting and calculate drug survival as an important measure of efficacy and compliance. Read More

    IL-36γ inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis.
    Int J Med Sci 2017 18;14(10):1002-1007. Epub 2017 Aug 18.
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
    Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte inflammation and differentiation that has a major impact on patients' quality of life. IL-36γ, a member of IL-36 cytokine family, is highly expressed in psoriasis and plays an important role in inflammation response and differentiation. However, the function of IL-36γ in differentiation and inflammation of keratinocyte in psoriasis has not been clearly identified. Read More

    Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection.
    J Neurochem 2017 Sep 16. Epub 2017 Sep 16.
    Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
    Dimethyl fumarate (DMF) is an immunomodulatory therapeutic for multiple sclerosis and psoriasis with neuroprotective potential. Its mechanism of action involves activation of the antioxidant pathway regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) thereby increasing synthesis of the cellular antioxidant glutathione (GSH). The objective of this study was to investigate whether post-traumatic DMF treatment is beneficial after experimental traumatic brain injury (TBI). Read More

    Pharmacogenetics and Pharmacogenomics in Moderate-to-Severe Psoriasis.
    Am J Clin Dermatol 2017 Sep 18. Epub 2017 Sep 18.
    Dermatology Department, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria la Princesa (IIS-IP), Madrid, Spain.
    Pharmacogenetics is the study of variations in DNA sequence related to drug response. Moreover, the evolution of biotechnology and the sequencing of human DNA have allowed the creation of pharmacogenomics, a branch of genetics that analyzes human genes, the RNAs and proteins encoded by them, and the inter-and intra-individual variations in expression and function in relation to drug response. Pharmacogenetics and pharmacogenomics are being used to search for biomarkers that can predict response to systemic treatments, including those for moderate-to-severe psoriasis. Read More

    Psoriasis and vitiligo are close relatives.
    Clin Cosmet Investig Dermatol 2017 29;10:341-345. Epub 2017 Aug 29.
    Department of Dermatology and Venereology, Baghdad Teaching Hospital, Baghdad, Iraq.
    Background: Both vitiligo and psoriasis are chronic inflammatory autoimmune diseases with genetic elements.

    Objective: To estimate the frequencies of psoriasis in vitiligo patients and vice versa and to compare them with healthy controls.

    Patients And Methods: A total of 1000 subjects were included, 250 of them had vitiligo, 250 had psoriasis, and 500 were healthy controls. Read More

    New insight into the pathogenesis of nail psoriasis and overview of treatment strategies.
    Drug Des Devel Ther 2017 30;11:2527-2535. Epub 2017 Aug 30.
    Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.
    Psoriasis is a chronic inflammatory disease affecting up to 3% of the general population. The prevalence of nail involvement in psoriasis patients varies between 15% and 79%. While the nails represent a small portion of the body surface area, psoriasis in these areas can have a disproportionate influence on a patient's physical and psychosocial activities. Read More

    Pro-oxidant status and Nrf2 levels in psoriasis vulgaris skin tissues and dimethyl fumarate-treated HaCaT cells.
    Arch Pharm Res 2017 Sep 16. Epub 2017 Sep 16.
    Department of Dermatology, Soonchunhyang University Hospital, 59 Daesahwan-ro, Yongsan-gu, Seoul, 04401, Republic of Korea.
    Reactive oxygen species (ROS) contribute to pathogenesis of many inflammatory skin diseases, including psoriasis. The aim of this study is to compare antioxidant protein expression in psoriasis vulgaris (PV) skin tissues with that in normal skin tissues in vivo and to evaluate the effects of dimethyl fumarate (DMF), used for the treatment of psoriasis, on ROS generation and apoptosis in a human keratinocyte cell line HaCaT. Compared with normal skin tissues, PV skin tissues showed increased protein oxidation as well as down-regulation of Nrf2 and its regulatory proteins such as HO-1 and AKR1C3. Read More

    [Apparent worsening of psoriasis lesions revealing methotrexate overdosage].
    Ann Dermatol Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France.
    Background: Methotrexate (MTX) is an antimetabolite drug used in the treatment of cancers and autoimmune diseases and frequently in dermatology for cutaneous and/or arthritic psoriasis. Toxicities due to MTX overdosage are mainly cutaneous, hepatic and hematologic. Herein, we report a case of MTX overdosage presenting as an erosive and an inflammatory flare of preexisting psoriatic plaques and with new palmar lesions. Read More

    Systematic review and meta-analysis of the association between psoriasis and metabolic syndrome.
    J Am Acad Dermatol 2017 Oct;77(4):657-666.e8
    Universidad del Valle and Universidad Libre, Cali, Colombia.
    Background: Several studies have shown a relationship between psoriasis and metabolic syndrome (MS), but no meta-analysis has been restricted to studies that adjusted for confounders.

    Objective: To determine the association between psoriasis and MS.

    Methods: A systematic review and meta-analysis of observational studies on psoriasis and MS in adults was performed from MEDLINE, Scopus, SciELO, Google Scholar, Science Direct, and LILACS from inception to January 2016. Read More

    Serious infections among a large cohort of subjects with systemically treated psoriasis.
    J Am Acad Dermatol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts; Department of Population Medicine, Harvard Medical School, Boston, Massachusetts; Division of Research, Kaiser Permanente Northern California, Oakland, California.
    Background: Biologic therapy is effective for treatment of moderate-to-severe psoriasis but may be associated with an increased risk for serious infection.

    Objective: To estimate the serious infection rate among patients with psoriasis treated with biologic as compared with nonbiologic systemic agents within a community-based health care delivery setting.

    Methods: We identified 5889 adult Kaiser Permanente Northern California health plan members with psoriasis who had ever been treated with systemic therapies and calculated the incidence rates and 95% confidence intervals (CIs) for serious infections over 29,717 person-years of follow-up. Read More

    Efficacy and safety of ixekizumab for the treatment of moderate-to-severe plaque psoriasis: Results through 108 weeks of a randomized, controlled phase 3 clinical trial (UNCOVER-3).
    J Am Acad Dermatol 2017 Sep 13. Epub 2017 Sep 13.
    Dermatologikum Hamburg and SCIderm Research Institute, Hamburg, Germany.
    Background: Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin 17A, is efficacious in treating moderate-to-severe plaque psoriasis through 60 weeks.

    Objective: To evaluate the efficacy and safety of ixekizumab through 108 weeks of treatment in UNCOVER-3.

    Methods: Patients (N = 1346) were randomized 2:2:2:1 to 80 mg ixekizumab every 2 or 4 weeks, 50 mg etanercept twice weekly, or placebo. Read More

    Uncovering burden disparity: A comparative analysis of the impact of moderate-to-severe psoriasis and hidradenitis suppurativa.
    J Am Acad Dermatol 2017 Sep 13. Epub 2017 Sep 13.
    Genesis Research, Hoboken, New Jersey. Electronic address:
    Background: Psoriasis and hidradenitis suppurativa (HS) exhibit distinct clinical features, but no studies have directly compared the health-related quality of life (HRQoL) in patients with moderate-to-severe manifestations of these conditions.

    Objective: To determine which disease is associated with more severe HRQoL impairment.

    Methods: Weighted averages of each of the following baseline HRQoL measures were determined and compared between HS and psoriasis populations from 5 clinical trials: Visual Analog Scale (VAS) for pain, Total Work Productivity Impairment, Dermatology Life Quality Index; EuroQOL 5D VAS, and Short Form-36 Health Survey. Read More

    Revisiting murine models for atopic dermatitis and psoriasis with multipolar cytokine axes.
    Curr Opin Immunol 2017 Sep 12;48:99-107. Epub 2017 Sep 12.
    Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara, Sakyoku, Kyoto 606-8507, Japan.
    Atopic dermatitis (AD) and psoriasis are one of the common skin diseases. Animal models are a powerful tool to analyze these diseases, which are complicated by multiple cytokine pathways. However, many discrepancies between the human diseases and murine models have been noticed. Read More

    Alcohol-Related Mortality in Patients With Psoriasis: A Population-Based Cohort Study.
    JAMA Dermatol 2017 Sep 15. Epub 2017 Sep 15.
    Centre for Pharmacoepidemiology and Drug Safety, School of Health Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, England.
    Importance: People diagnosed with psoriasis have an increased risk of premature mortality, but the underlying reasons for this mortality gap are unclear.

    Objective: To investigate whether patients with psoriasis have an elevated risk of alcohol-related mortality.

    Design, Setting, And Participants: An incident cohort of patients with psoriasis aged 18 years and older was delineated for 1998 through 2014 using the Clinical Practice Research Datalink (CPRD) and linked to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) mortality records. Read More

    The spectrum of psoriatic arthritis in a South African cohort.
    Clin Rheumatol 2017 Sep 15. Epub 2017 Sep 15.
    Department of Medicine, Division of Rheumatology, University of Cape Town, Cape Town, South Africa.
    The aim of this study was to describe the clinical features of patients with psoriatic arthritis (PsA) in a South African cohort. This is a retrospective analysis of patients contributing to development of the international classification criteria for PsA, ClASsification criteria for Psoriatic ARthritis (CASPAR). Patients were all seen at the arthritis clinics at Groote Schuur Hospital, Cape Town. Read More

    Phytomedicines are efficient complementary therapies for the treatment of atopic dermatitis: A review of mechanistic insight and recent updates.
    Curr Drug Targets 2017 Sep 13. Epub 2017 Sep 13.
    Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor. Malaysia.
    Background: Phytomedicines have been well-accepted alternative complementary therapies for the treatment of a wide range of acute and chronic skin inflammatory diseases including chronic herpes, prurigo, psoriasis, and atopic dermatitis (AD). Plethora of in vitro and in vivo studies have evidenced the therapeutic viability of phytomedicines, polyherbal formulations, plant-based materials and their decoctions for the treatment of mild-to-severe AD.

    Objective: This review was aimed to summarize and critically discuss the convincing evidence for the therapeutic effectiveness of phytomedicines for the treatment of AD and explore their anti-AD efficacy. Read More

    [Psoriasis and Psoriatic Arthritis Induced by Nivolumab in a Patient with Advanced Non-Small-Cell Lung Cancer].
    Gan To Kagaku Ryoho 2017 Sep;44(9):787-789
    Dept. of Thoracic Surgery, National Hospital Organization, Kanagawa National Hospital.
    Background: Immune checkpoint-blocking antibodies may induce specific side effects known as immune-relatedad verse events.

    Case Presentation: A 66-year-oldman without any history of autoimmune disease was referredto our hospital for treatment of lung cancer in the right upper lobe. The tumor was diagnosed as Stage III A non-small-cell lung cancer by using bronchoscopic biopsy, computedtomography, andFDG -PET. Read More

    Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice.
    J Food Drug Anal 2017 Jul 5;25(3):559-566. Epub 2016 Aug 5.
    Department of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan. Electronic address:
    Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L. Read More

    Psoriasis-associated vascular disease: the role of HDL.
    J Biomed Sci 2017 Sep 14;24(1):73. Epub 2017 Sep 14.
    CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056, Lisboa, Portugal.
    Psoriasis is a chronic inflammatory systemic disease with a prevalence of 2-3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiovascular disease is the most frequent cause of death in patients with severe psoriasis. Read More

    Developing a protocol to identify and prioritise research questions for psoriasis: A James Lind Alliance Priority Setting Partnership.
    Br J Dermatol 2017 Sep 14. Epub 2017 Sep 14.
    Department of Dermatology, The University of Manchester, Manchester Academic Health Science Centre, Manchester, England, UK.
    Background: Psoriasis affects over two million people in the UK. It confers a significant psychological and social impact on individuals and an associated high economic cost to the National Health Service. There are many unanswered questions about psoriasis. Read More

    Alopecia as unique clue to syphilis in a patient.
    G Ital Dermatol Venereol 2017 Oct;152(5):520-523
    Department Medical Science "M. Aresu", Dermatology Clinic, University of Cagliari, Cagliari, Italy.
    Alopecia is an uncommon manifestation of syphilis, simulating other common forms of hair-loss, but representing a crucial complaint for the patient, who might by converse have not noticed other signs and symptoms of the disease. Esthetic issues undervaluation might prolong illness, and postpone appropriate treatment. A 42-year-old patient, HIV negative, presented with a 2-month history of progressive generalized thinning of the hairs and small non-scarring irregular alopecia patches of the parietal-occipital areas of the scalp. Read More

    Effectiveness and safety of secukinumab in 69 patients with moderate to severe plaque psoriasis: A retrospective multicenter study.
    Dermatol Ther 2017 Sep 14. Epub 2017 Sep 14.
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
    Secukinumab (anti-IL17A) is effective as treatment for moderate to severe plaque psoriasis, but real-life data on effectiveness and safety lack. We aimed to present real-life data of all Danish patients treated with secukinumab (n = 69). At baseline, before initiation of treatment with secukinumab 300 mg (47. Read More

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