55,160 results match your criteria Psoriasis

An analysis of the relative and absolute incidence of somatic morbidity in patients with affective disorders-A nationwide cohort study.

J Affect Disord 2021 Jun 7;292:204-211. Epub 2021 Jun 7.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospitals, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark; Section for Epidemiology, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Copenhagen K 1014, Denmark.

Background: Patients with affective disorder seem to experience higher risks of several somatic diseases, but no studies have provided estimates of both absolute and relative risks for these diseases in the same population.

Methods: A prospective cohort of all patients age ≥18 years old with a hospital contact with affective disorder between 1997-2014 (n=246,282) and a random sample from the background population (n=167,562) was followed for hospitalizations with cardiovascular disease, diabetes, cancers, chronic obstructive pulmonary disease (COPD), asthma, inflammatory bowel disease, hip fracture, psoriasis, migraine, or dementia. Adjusted absolute and relative risk estimates were calculated using multivariable adjusted Aalen's additive and Cox proportional hazard regression models. Read More

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Characteristics of patients with PASI <10 psoriasis treated with biological agents: Results from the French PsoBioTeq cohort.

Br J Dermatol 2021 Jun 15. Epub 2021 Jun 15.

INSERM, Pierre Louis Institute for Epidemiology and Public Health, Assistance Publique - Hôpitaux de Paris (AP-HP). Sorbonne University, Pitié Salpêtrière Hospitals, Public Health Department, Pharmacoepidemiology Centre, CIC-1422, Paris, France.

Decision to initiate systemic therapy in psoriasis is mainly based on disease severity assessments, determined using physicians' derived scores, e.g. the Psoriasis Area and Severity Index (PASI), an absolute value of 10 or more indicates severe disease. Read More

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Development and preliminary validation of the patient-reported Chronic Itch Burden Scale, assessing health-related quality of life in chronic pruritus.

Br J Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Univ Brest, LIEN and University Hospital of Brest, Department of Dermatology, 2 avenue Foch, F-29200, Brest, France.

Background: Chronic pruritus (CP) significantly affects patients' health-related quality of life (HRQoL). Very few self-reported HRQoL questionnaires exploring CP were developed according to international guidelines thus limiting their use in pre-authorization trials.

Objectives: To develop a self-reported HRQoL questionnaire in patients with CP due to psoriasis, atopic dermatitis, seborrheic dermatitis of the scalp or idiopathic dermatitis; to explore its preliminary psychometric properties. Read More

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Possible role of epiregulin from dermal fibroblasts in the keratinocyte hyperproliferation of psoriasis.

J Dermatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Psoriasis, an immune-mediated inflammatory disease, is characterized by keratinocyte hyperproliferation. Tumor necrosis factor (TNF)-α, interleukin (IL)-23, and IL-17A play critical roles in the pathogenesis of psoriasis. IL-17A secreted by T-helper 17 acts more directly against keratinocytes than TNF-α or IL-23 do. Read More

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Alcohol abuse associated with poor response to systemic therapies for psoriasis: findings from a prospective multicentre cohort study.

Br J Dermatol 2021 Jun 14. Epub 2021 Jun 14.

Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK.

Background: Factors that might influence response to systemic treatment for moderate-to-severe psoriasis are varied, and generally, are poorly understood, aside from high body weight, suggesting that other unidentified factors may be relevant in determining response to treatment. The impact of alcohol abuse on treatment response has not been previously investigated.

Objective: To investigate whether alcohol abuse is associated with poor response to treatment for psoriasis. Read More

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Alarmins/stressorins and immune dysregulation in intractable skin disorders.

Allergol Int 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan.

Unlike other barrier epithelia of internal organs, the stratified squamous epithelium of the skin is always exposed to the external environment. However, the robust barrier structure and function of the skin are highly resistant against external insults so as to not easily allow foreign invasions. Upon sensing danger signals, the innate immunity system is promptly activated. Read More

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Tacrolimus-loaded chitosan nanoparticles for enhanced skin deposition and management of plaque psoriasis.

Carbohydr Polym 2021 Sep 23;268:118238. Epub 2021 May 23.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Tacrolimus is a natural macrolide that exhibits an anti-proliferative action by T-lymphocytic cells inhibition. Hence, it was tested as a potential topical treatment to improve and control psoriatic plaques. In this study, for the first time the lipophilic tacrolimus in chitosan nanoparticles was used to achieve the desired response and dermal retention of the drug using a modified ionic gelation technique. Read More

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September 2021

Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review.

Arthritis Res Ther 2021 Jun 14;23(1):168. Epub 2021 Jun 14.

Department of Rheumatology, Sint Maartenskliniek, PO box 9011, 6500 GM, Nijmegen, The Netherlands.

Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conducted a systematic search of five bibliographic databases, up to May 2020. Read More

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Pregnancy and neonatal outcomes in women with immune mediated inflammatory diseases exposed to anti-tumor necrosis factor-α during pregnancy: A systemic review and meta-analysis.

J Autoimmun 2021 Jun 11;122:102676. Epub 2021 Jun 11.

Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

Background: Anti-TNFα is increasingly used as treatment for immune mediated inflammatory diseases (IMID), such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA) and psoriasis (PS). However, the impact of anti-TNFα during pregnancy on mother and newborn is under debate. This requires a sound knowledge of the effects of this treatment on pregnancy and neonatal outcomes. Read More

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Management of inadequate response and adverse effects to dupilumab in atopic dermatitis.

J Am Acad Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Oregon Health and Science University, Portland, OR 97239. Electronic address:

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus, skin-pain, and sleep disturbances. Currently, dupilumab is the only U.S. Read More

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Gene Expression Profiles of Circular RNAs and MicroRNAs in Chronic Rhinosinusitis With Nasal Polyps.

Front Mol Biosci 2021 28;8:643504. Epub 2021 May 28.

Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Chronic rhinosinusitis (CRS) is often classified primarily on the basis of the absence or presence of nasal polyps (NPs), that is, as CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP). Additionally, according to the percentage of eosinophils, CRSwNP can be further divided into eosinophilic CRSwNP (ECRSwNP) and non-ECRSwNP. CRSwNP is a significant public health problem with a considerable socioeconomic burden. Read More

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Apremilast in the Management of Disseminated Granuloma Annulare.

Cureus 2021 May 9;13(5):e14918. Epub 2021 May 9.

Dermatology, St. Joseph Dermatopathology, Houston, USA.

Granuloma annulare (GA) is a common inflammatory skin condition that manifests as annular skin colored to erythematous papules and plaques. Disseminated GA is a subtype of GA that presents with diffuse cutaneous involvement. While topical and intralesional corticosteroids and phototherapy have been used as therapies for GA, there is no consensus on the best course of treatment for GA. Read More

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Calcipotriol/Betamethasone Dipropionate Aerosol Foam for Plaque Psoriasis: A Prospective, Observational, Non-Interventional, Single-Center Study of Patient Adherence and Satisfaction in Daily Use.

Dermatol Pract Concept 2021 May 20;11(3):e2021056. Epub 2021 May 20.

Department of Psoriasis, Dermatology, Hospital Universitario San Cecilio, Granada, Spain.

Background: Psoriasis is a chronic inflammatory disease that has a negative impact on patients' quality of life. Patients with mild-moderate psoriasis can be treated with topical medications, such as the combination drug calcipotriol/betamethasone dipropionate (Cal/BD).

Objectives: This study investigated the adherence of psoriasis patients to therapy with Cal/BD aerosol foam, as well as their satisfaction with the treatment's efficacy, safety, and effect on their quality of life. Read More

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Management of a Chronic Skin Disease in Primary Care: An Analysis of Early-Career General Practitioners' Consultations Involving Psoriasis.

Dermatol Pract Concept 2021 May 20;11(3):e2021055. Epub 2021 May 20.

The University of Newcastle, School of Medicine and Public Health, Callaghan, NSW, Australia.

Background: The management of psoriasis by general practitioners (GPs) is vital, given its prevalence, chronicity, and associated physical and psychosocial co-morbidities. However, there is little information on how GPs (including early-career GPs) manage psoriasis.

Objectives: This study assessed the frequency with which Australian specialist GP vocational trainees ('registrars') provide psoriasis care and the associations of that clinical experience. Read More

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Prevalence of Metabolic Syndrome and Its Parameters and Their Correlations With Psoriasis Duration, Severity, and Sleep Quality In Psoriasis Patients: A Cross-Sectional Study.

Dermatol Pract Concept 2021 May 20;11(3):e2021049. Epub 2021 May 20.

Department of Neurology, University of Health Sciences, Bakirkoy Prof. Dr. Mazhar Osman Research and Training Hospital, Istanbul, Turkey.

Background: Psoriasis is an inflammatory skin disease that may lead to comorbidities, including metabolic syndrome (MS).

Objective: We determined the prevalence of MS and its correlation with psoriasis duration, severity, and sleep quality in psoriasis patients.

Methods: A total of 112 subjects with chronic plaque psoriasis were studied. Read More

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Dimethyl fumarate titration for the systemic treatment of moderate-to-severe plaque psoriasis.

Drugs Context 2021 31;10. Epub 2021 May 31.

Dermatology Department, DissaL, Policlinico San Martino IRCCS, Genova, Italy.

Background: Dimethyl fumarate (DMF) is an oral systemic agent approved for the treatment of moderate-to-severe psoriasis vulgaris. It has a favourable tolerability profile, but it is associated with a high incidence of mild and reversible adverse events. The aim of the article is to describe a clinical experience aimed at increasing tolerability. Read More

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Association of Circulating Vascular Endothelial Growth Factor Levels With Autoimmune Diseases: A Systematic Review and Meta-Analysis.

Front Immunol 2021 27;12:674343. Epub 2021 May 27.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Autoimmune diseases (ADs) are characterized by immune-mediated tissue damage, in which angiogenesis is a prominent pathogenic mechanism. Vascular endothelial growth factor (VEGF), an angiogenesis modulator, is significantly elevated in several ADs including rheumatoid arthritis (RA), systemic sclerosis (SSc), and systemic lupus erythematosus (SLE). We determined whether circulating VEGF levels were associated with ADs based on pooled evidence. Read More

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Exploring the Pathogenesis of Psoriasis Complicated With Atherosclerosis Microarray Data Analysis.

Front Immunol 2021 27;12:667690. Epub 2021 May 27.

Department of Dermatology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Although more and more evidence has supported psoriasis is prone to atherosclerosis, the common mechanism of its occurrence is still not fully elucidated. The purpose of this study is to further explore the molecular mechanism of the occurrence of this complication.

Methods: The gene expression profiles of psoriasis (GSE30999) and atherosclerosis (GSE28829) were downloaded from the Gene Expression Omnibus (GEO) database. Read More

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Mental health outcomes in White patients versus patients with skin of color with psoriasis.

Dermatol Online J 2021 May 15;27(5). Epub 2021 May 15.

Keck School of Medicine, University of Southern California, Los Angeles, CA.

Objective: To evaluate the relationship between psoriasis and mental health in patients from different racial backgrounds.

Methods: We performed a nationwide, cross-sectional study evaluating 7,519,662 (weighted) patients, comparing White patients versus patients with skin of color (SOC), using the 2004-2017 Medical Expenditure Panel Survey (MEPS).

Results: Psychological distress (measured by Kessler 6-Item Psychological Distress Scale) was similar between White and SOC patients (4. Read More

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How lockdown measures, during COVID-19 pandemic, matter on psoriatic patient's perception: Study on 600 patients on biologic therapy.

J Infect Public Health 2021 Apr 1;14(7):878-882. Epub 2021 Apr 1.

Dermatology Unit "D. Innocenzi", Polo Pontino, Sapienza University of Rome, Rome, Italy.

Background: The outbreak of coronavirus disease-2019 (COVID-19) is a public health crisis of global proportion. In psoriatic patients treated with biologic agents, evidence is not yet available on susceptibility to infection with the novel SARS-CoV-2 coronavirus, and data about the perception of COVID-19 and its impact on these patients are lacking.

Aims: The aim of this observational, spontaneous study was the evaluation of the impact of anti COVID-19 measures in "fragile population" such as patients with a chronic inflammatory disease. Read More

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Risk of psoriasis according to body mass index: a retrospective cohort analysis.

J Am Acad Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, NY, USA. Electronic address:

Background: Psoriasis has been linked to obesity, although there is limited data on the incidence of psoriasis according to body mass index.

Objective: To compare incidence of psoriasis among patients stratified by BMI category (normal or underweight, overweight, obese-class 1, obese-class 2/3).

Methods: Retrospective cohort analysis of a demographically heterogeneous sample of over 1. Read More

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Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies.

Eur J Pharmacol 2021 Jun 9;907:174254. Epub 2021 Jun 9.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 492010, India. Electronic address:

Psoriasis is an autoimmune chronic inflammatory condition of skin affecting 125 million populaces around the globe. It is implicated as a result of multifaceted phenomena involving various cell and subcell activities with the aid of numerous cellular and molecular components including signaling aisle and regulatory proteins owing to the development of such hyperproliferative dermatological conditions. This involves a deeply complex and conflicting pathology owing to genetic and immunological deviations resulting from the unusual presentation of different signaling pathways and regulatory proteins. Read More

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Autoinflammatory keratinitzation diseases (AIKDs.

Actas Dermosifiliogr 2021 Jun 9. Epub 2021 Jun 9.

Servicio de Dermatología, Consorci Corporació Sanitària Parc Taulí, Universidad Autónoma de Barcelona, Spain.

Autoinflammatory keratinization disease (AiKD) is a novel clinical concept encompassing diseases with a genetic background and mixed pathogenic mechanisms of autoinflammation and autoimmunity, leading to an aberrant keratinization of the skin. Recent advances in medical genetics have revealed genetic causes and/or predisposing factors for a number of AiKD's, such as mutations in IL36RN related with pustular psoriasis, acrodermatitis continua and hidradenitis suppurativa, in CARD14 in pityriasis rubra pilaris type V and some forms of pustular psoriasis, and in NLRP1 related with familial keratosis lichenoides chronica (KLC). It is suspected that AiKD pathophysiology would also be involved in non-monogenic disorders. Read More

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Treatments and outcomes of generalized pustular psoriasis: a cohort of 1516 patients in a nationwide inpatient database in Japan.

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Background: Because generalized pustular psoriasis (GPP) is uncommon, there are few studies reporting treatments and outcomes for large numbers of patients.

Objective: To report treatments and outcomes in a large cohort of hospitalized patients with GPP.

Methods: Using a Japanese national inpatient database, we identified 1516 patients with GPP who required hospitalization from July 2010 to March 2019. Read More

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[The skin microbiome-useful for diagnosis and therapy?]

Hautarzt 2021 Jun 11. Epub 2021 Jun 11.

Institut für Umweltmedizin, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, München, Deutschland.

Background: Our skin is a very important and complex organ of the body. The microorganisms of the skin, the so-called microbiome, represent an important part of the healthy skin barrier and are influenced by various external and internal factors.

Aim: The question to what extent the skin microbiome represents a diagnostic or even therapeutic target in the context of skin diseases is discussed. Read More

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A case report of monoarthritis in a COVID-19 patient and literature review: Simple actions for complex times.

Medicine (Baltimore) 2021 Jun;100(23):e26089

Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano.

Rationale: COVID-19 presentation is multifaceted and up to 44% of patients affected by COVID-19 experience musculoskeletal complaints, mostly in the form of diffuse aspecific arthromyalgias. Nevertheless, only a few cases of arthritis following SARS-CoV2 infection are reported.

Patient Concerns: A 27-year-old man affected by nail psoriasis presented with monoarthritis 2 weeks after being diagnosed with COVID-19. Read More

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Successful management of treatment resistant nail psoriasis with tildrakizumab.

Australas J Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Dermatology Department, The Royal Melbourne Hospital, Parkville, Victoria, Australia.

Nail psoriasis significantly impacts quality of life and is notoriously difficult to treat. Tildrakizumab, an IL-23 inhibitor, has shown significant clinical improvement in the treatment of moderate-to-severe chronic plaque psoriasis. We report 2 cases of treatment resistant nail psoriasis which showed marked improvement with the use of off-label tildrakizumab. Read More

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Use of brodalumab for the treatment of chronic plaque psoriasis: a one-year real-life study in the Lazio region, Italy.

Expert Opin Biol Ther 2021 Jun 11. Epub 2021 Jun 11.

Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Dermatologia, Rome, Italy.

Background: Information is limited from real-life studies evaluating the efficacy and safety of brodalumab.

Research Design And Methods: In this real-life study, we retrospectively examined a database of 90 patients with moderate-to-severe psoriasis treated with brodalumab (210 mg, s.c. Read More

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Single-nucleotide polymorphism and haplotype analysis of macrophage migration inhibitory factor gene and its correlation with serum macrophage migration inhibitory factor levels in North Indian psoriatic patients with moderate disease severity: A cross-sectional study.

Indian J Dermatol Venereol Leprol 2021 May 8:1-7. Epub 2021 May 8.

Department of Dermatology, Venereology and Leprosy, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Psoriasis is associated with significant morbidity and impaired quality of life. Identification of the host genes that influence disease susceptibility and can potentially guide future, targeted therapy is the need of the hour.

Aims: The aim of the study was to investigate the associations of macrophage migration inhibitory factor (MIF) gene polymorphisms, that is, a 5-8-CATT tetra nucleotide repeats at -794 (-794*CATT5-8) and a single-nucleotide polymorphism at -173 (-173*G/C) with the risk of chronic plaque psoriasis and to observe the correlation, if any, of disease determinants with genetic functional variants and circulating MIF levels. Read More

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