47,479 results match your criteria Psoriasis


The pharmacological management of patients with comorbid psoriasis and obesity.

Expert Opin Pharmacother 2019 Feb 22:1-10. Epub 2019 Feb 22.

b Section of Dermatology and Venereology, Department of Medicine , University of Verona , Verona , Italy.

Introduction: Psoriasis is a chronic inflammatory skin disease that is increasingly being recognized as a complex disorder affecting multiple systems. Systemic inflammation is considered the pathogenic link between psoriasis and its comorbid conditions that include arthritis, metabolic disorders, depression, and cardiovascular diseases. The presence of comorbid conditions modifies both its clinical management and the therapeutic approach in psoriatic patients. Read More

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http://dx.doi.org/10.1080/14656566.2019.1583207DOI Listing
February 2019

French guidelines on the use of systemic treatments for moderate-to-severe psoriasis in adults.

J Eur Acad Dermatol Venereol 2019 Feb 22. Epub 2019 Feb 22.

Centre de Preuves en Dermatologie, Paris, France.

These guidelines were developed by the psoriasis research group of the French Society of Dermatology with the aim of providing updated decision-making algorithms for the systemic treatment of adult patients with moderate-to-severe psoriasis. Our algorithms were generated after rigorous evaluation of existing guidelines on the treatment of psoriasis and of publications concerning new systemic treatments, not yet incorporated into existing guidelines. A total of nine existing guidelines and 53 publications related to new systemic treatments were found to meet our criteria for use in the generation of the algorithms. Read More

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http://dx.doi.org/10.1111/jdv.15340DOI Listing
February 2019

Pseudolymphoma induced by secukinumab for treatment of chronic plaque psoriasis.

Australas J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/ajd.13009DOI Listing
February 2019

Short-term risk of major adverse cardiovascular events or congestive heart failure in patients with psoriatic arthritis or psoriasis initiating a biological therapy: a meta-analysis of randomised controlled trials.

RMD Open 2019 24;5(1):e000763. Epub 2019 Jan 24.

Rhumatologie, Hôpital Purpan, Toulouse III Université, Toulouse, France.

Objective: The objective was to investigate the short-term risk of major adverse cardiovascular events (MACEs) or congestive heart failure (CHF) in patients with psoriatic arthritis (PsA) or psoriasis initiating a biological therapy.

Methods: Screening for the study was carried out using MEDLINE, Cochrane and Embase, from the inception of the database to December 2017. Randomised controlled trials (RCTs) of anti-tumour necrosis factor (TNF), anti-interleukin (IL)12/23, anti-IL23 and anti-IL17 agents for the treatment of PsA or psoriasis were included. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350717PMC
January 2019

Editorial: Langerhans Cells and How Skin Pathology Reshapes the Local Immune Environment.

Front Immunol 2019 7;10:139. Epub 2019 Feb 7.

Biosciences Department, Durham University, Durham, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.00139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375340PMC
February 2019

Incremental Cost per Responder (PASI-75, PASI-90 and PASI-100) Based on a Network Meta-Analysis of Biologic Therapies for Psoriasis: Spain 2018.

Authors:
L Puig

Actas Dermosifiliogr 2019 Feb 18. Epub 2019 Feb 18.

Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España. Electronic address:

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http://dx.doi.org/10.1016/j.ad.2018.12.002DOI Listing
February 2019

A retrospective cohort study to evaluate the development of comorbidities, including psychiatric comorbidities, among a pediatric psoriasis population.

Pediatr Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Amgen Inc., Thousand Oaks, California.

Background/objective: Compared with the adult psoriasis population, knowledge about the incidence of comorbidities in the pediatric psoriasis population is limited. The objective of this study was to assess the prevalence and incidence of comorbidities, including psychiatric comorbidities, in patients with pediatric psoriasis.

Methods: In this claims-based, retrospective cohort study, patients with pediatric psoriasis were matched 1:3 with a nonpsoriasis cohort based on age, sex, and index date (the earliest of inpatient claims or the latter of two outpatient claims). Read More

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http://dx.doi.org/10.1111/pde.13772DOI Listing
February 2019

Practical Guidelines for Managing Patients With Psoriasis on Biologics: An Update.

J Cutan Med Surg 2019 Jan/Feb;23(1_suppl):3S-12S

1 Cumming School of Medicine, Division of Dermatology, University of Calgary, Calgary, AB, Canada.

The paradigm for treating inflammatory diseases has shifted dramatically in the past 10 to 20 years with the discovery of targeted therapeutics or "biologic" agents. Patients with rheumatoid arthritis, inflammatory bowel disease, psoriatic arthritis, and psoriasis, among others, are reaping the benefits of decades of bench to bedside research, allowing them to live more productive lives with less side effects than traditional systemic therapies. Despite these advances, many physicians unfamiliar with biologics are left to care for the basic needs of these patients and may be unaware of the multisystem comorbidities associated with psoriasis and the screening, monitoring, and other special considerations required of biologics patients. Read More

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http://dx.doi.org/10.1177/1203475418811347DOI Listing
February 2019

Interleukin-17 receptor A blockade with brodalumab in palmoplantar pustular psoriasis: Report on four cases.

J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Venereology and Allergology, University Clinic Göttingen, Göttingen, Germany.

Palmoplantar pustular psoriasis, also termed palmoplantar pustulosis (PPP), is a rare disease affecting the palmoplantar regions characterized by sterile, yellow to brown pustules mostly on erythematous skin. PPP is related to a high burden due to painful, impaired and stigmatizing character. Several isoforms of interleukin (IL) have been implicated in its pathophysiology. Read More

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http://dx.doi.org/10.1111/1346-8138.14815DOI Listing
February 2019

Association of Atherosclerosis Prevalence With Age, Race, and Traditional Risk Factors in Patients With Psoriasis.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamadermatol.2018.5462DOI Listing
February 2019

Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population.

Epigenomics 2019 Feb 20. Epub 2019 Feb 20.

HumanBiology, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.

Aim: A genomic region on 5q33.3 lies between and encompasses the IL12B and PTTG1 genes, and contains many potential psoriasis causal variants. We aimed to further examine the influence of variants in and around this region. Read More

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http://dx.doi.org/10.2217/epi-2018-0131DOI Listing
February 2019

Successful treatment of psoriasis induced by immune checkpoint inhibitors with apremilast.

Eur J Cancer 2019 Feb 18;110:107-109. Epub 2019 Feb 18.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1016/j.ejca.2019.01.010DOI Listing
February 2019

Study on the psychological health and related risk factors in 245 patients with psoriasis in Inner Mongolia.

Psychol Health Med 2019 Feb 20:1-12. Epub 2019 Feb 20.

a Department of Dermatology , Nanfang Hospital of Southern Medical University , Guangdong , China.

To investigate the psychological health and related risk factors in patients suffering from psoriasis. A total of 245 inpatients and outpatients with psoriasis were selected from January 2014 to December 2015. Patients with psoriasis were assessed a homemade questionnaire as well as the Psoriasis Area and Severity Index (PASI), Selfrating Anxiety Scale, Self-rating Depression Scale, Trait Coping Style Questionnaire and Social Avoidance and Distress Scale. Read More

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http://dx.doi.org/10.1080/13548506.2019.1574352DOI Listing
February 2019

Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin.

Skin Pharmacol Physiol 2019 Feb 15;32(2):94-100. Epub 2019 Feb 15.

Department of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Halle (Saale),

Background/aims: Free amino acids (FAAs) and urea, present inside the corneocytes, can be important indicators of skin condition. However, due to the lack of a standard extraction protocol for FAAs from corneocytes, conflicting research results have been reported. Therefore, the purpose of this study was (1) to standardize the extraction protocol and (2) to investigate FAA profiles in healthy young and healthy old volunteers, as well as in psoriasis and atopic dermatitis patients. Read More

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https://www.karger.com/Article/FullText/495992
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http://dx.doi.org/10.1159/000495992DOI Listing
February 2019
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Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called "Telocytopathies".

Medicina (Kaunas) 2019 Feb 18;55(2). Epub 2019 Feb 18.

Institute of Histology and Embryology, Faculty of Medicine, Comenius University in Bratislava, 813 72 Bratislava, Slovakia.

In recent years, the interstitial cells telocytes, formerly known as interstitial Cajal-like cells, have been described in almost all organs of the human body. Although telocytes were previously thought to be localized predominantly in the organs of the digestive system, as of 2018 they have also been described in the lymphoid tissue, skin, respiratory system, urinary system, meninges and the organs of the male and female genital tracts. Since the time of eminent German pathologist Rudolf Virchow, we have known that many pathological processes originate directly from cellular changes. Read More

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http://dx.doi.org/10.3390/medicina55020056DOI Listing
February 2019

Safety of metformin in psoriasis patients with diabetes mellitus: a 17-year population-based real-world cohort study.

J Clin Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Context: The safety of metformin usage by diabetic psoriasis patients is unclear.

Objective: To investigate the real-world safety of metformin in psoriatic patients with type 2 diabetes mellitus (T2DM).

Design: We used the National Health Insurance Research Database to perform a cohort study. Read More

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http://dx.doi.org/10.1210/jc.2018-02526DOI Listing
February 2019

Epigenome-wide analysis of sperm cells identifies IL22 as a possible germ line risk locus for psoriatic arthritis.

PLoS One 2019 19;14(2):e0212043. Epub 2019 Feb 19.

Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada.

Psoriasis and its associated inflammatory arthritis, psoriatic arthritis (PsA), have a clear heritable component, but a large proportion of the heritable risk remains unexplained by gene sequence variation. This study aimed to determine if epigenetic factors contribute to the missing heritability in psoriatic disease. DNA methylation profiling was performed on sperm cells from 23 probands with psoriasis without PsA (PsC), 13 PsA probands, and 18 unaffected controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212043PLOS
February 2019
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Efficacy of ω-3 supplementation in patients with psoriasis: a meta-analysis of randomized controlled trials.

Clin Rheumatol 2019 Feb 18. Epub 2019 Feb 18.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Several studies have been conducted with the aim of investigating the effect of Omega(ω)-3 on different psoriasis indices including Psoriasis Area and Severity Index (PASI) score, erythema, scaling, itching, area involved, and infiltration. Nevertheless, a pooled analysis of trials that evaluated these variables has not been conducted. Therefore, the aim of this meta-analysis was to assess the efficacy of ω-3 fatty acids in treating patients with psoriasis. Read More

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http://dx.doi.org/10.1007/s10067-019-04456-xDOI Listing
February 2019

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.

Front Cell Infect Microbiol 2019 4;9. Epub 2019 Feb 4.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

Psoriasis vulgaris is a chronic inflammatory skin condition, associated with both a physical and a psychological burden. Our understanding of the etiology of this disease remains incomplete. Conventionally, psoriasis has been viewed as a condition that manifests solely in the skin. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369634PMC
February 2019

Hyperglycemia is associated with psoriatic inflammation in both humans and mice.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. Electronic address:

Chronic low-grade inflammation can cause several metabolic syndromes. Patients with psoriasis, a chronic immunological skin inflammation, often develop diabetes. However, it is not clear to date how psoriasis leads to, or is correlated with, glucose intolerance. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.029DOI Listing
February 2019

GLP-1 receptor agonist impairs keratinocytes inflammatory signals by activating AMPK.

Exp Mol Pathol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology and Venerology,Chongqing Three Gorges Central Hospital, ChongQing 404100, China.

Purpose: Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, is an antidiabetic drug. It has been shown to improve the Psoriasis Area and Severity Index (PASI) in patients with type 2 diabetes and psoriasis in clinical practice, but the mechanism remains somewhat unclear. We used lipopolysaccharides (LPS) to induce inflammatory response in keratinocytes and explore the mechanism. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.01.014DOI Listing
February 2019

Apremilast in a patient with psoriasis and mantle cell lymphoma under maintenance treatment with rituximab.

Authors:
Wiebke K Peitsch

J Dtsch Dermatol Ges 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology and Phlebology, Vivantes Klinikum im Friedrichshain, Berlin, Germany.

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http://dx.doi.org/10.1111/ddg.13771DOI Listing
February 2019
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Widespread Superficial Dermatophytosis in Patient on Secukinumab for Treatment of Chronic Plaque Psoriasis.

Indian Dermatol Online J 2019 Jan-Feb;10(1):76-78

Department of Dermatology, Command Hospital, Kolkata, West Bengal, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_170_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362754PMC
February 2019

Acute Methotrexate Toxicity Due to Overdosing in Psoriasis: A Series of Seven Cases.

Indian Dermatol Online J 2019 Jan-Feb;10(1):64-68

Department of Dermatology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Overdosing is the major cause of acute methotrexate toxicity in psoriasis patients. There are no published data regarding the acute cumulative dose causing acute toxicity, duration to achieve acute cumulative toxic dose and various reasons for wrong dosing of methotrexate in Indian patients. We are presenting a series of seven cases of toxicity due to overdosing of methotrexate in psoriasis. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_157_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362756PMC
February 2019

Clinico-Epidemiological Profile of Patients with Vitiligo: A Retrospective Study from a Tertiary Care Center of North India.

Indian Dermatol Online J 2019 Jan-Feb;10(1):38-44

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: We studied clinico-epidemiological features of 945 patients with vitiligo with an objective to delineate epidemiological and clinical aspects of vitiligo from this part of the country.

Materials And Methods: The medical records of patients with vitiligo attending outpatient clinic over a 5-year period from January 2013 to December 2017 were analyzed retrospectively for this descriptive, observational study.

Results: There were 449 men and 496 women (m:f 1:1. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_124_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362747PMC
February 2019

Apremilast in Psoriasis and Beyond: Big Hopes on a Small Molecule.

Indian Dermatol Online J 2019 Jan-Feb;10(1):1-12

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Apremilast, an orally administered small molecule inhibitor of phosphodiesterase 4 (PDE4), has been licensed by the US Food and Drug Administration for the management of active psoriatic arthritis (March 21, 2014) and moderate to severe plaque psoriasis (September 23, 2014). It has got approval from Drug Controller General of India for marketing in India in 2017. The drug has drawn much attention from the practising dermatologists for its commendable safety profile and prescription convenience. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_437_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362739PMC
February 2019

Dermoscopic Features of Psoriasis, Lichen Planus, and Pityriasis Rosea in Patients With Skin Type IV and Darker Attending the Regional Dermatology Training Centre in Northern Tanzania.

Dermatol Pract Concept 2019 Jan 31;9(1):44-51. Epub 2019 Jan 31.

Public, Private, and Teaching Practice of Dermatology, Konstanz, Germany.

Background: Papulosquamous skin diseases can be challenging to diagnose, especially in dark skin. Dermoscopy is reported to be helpful, but few data are available on its use in skin type IV or darker.

Objective: To describe dermoscopic features in plaque-type psoriasis (PP), lichen planus (LP), and pityriasis rosea (PR) patients attending the Regional Dermatology Training Centre in Moshi, Northern Tanzania, and to compare findings with published data. Read More

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http://dx.doi.org/10.5826/dpc.0901a11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368079PMC
January 2019

Novel systemic therapies in atopic dermatitis: what do we need to fulfil the promise of a treatment revolution?

F1000Res 2019 31;8. Epub 2019 Jan 31.

Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

Patients with atopic dermatitis (AD) who do not adequately respond to topical therapy and phototherapy often need systemic immunomodulatory treatment to control their symptoms. Conventional systemic agents, such as ciclosporin, azathioprine, and methotrexate, have been used for decades, but there are concerns about their safety profile. There are now many novel systemic agents emerging through clinical trials, which may have great potential in the treatment of AD. Read More

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http://dx.doi.org/10.12688/f1000research.17039.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357995PMC
January 2019

Self-assembling water-soluble polymethacrylate-MTX conjugates: The significance of macromolecules architecture on drug conjugation efficiency, the final shape of particles, and drug release.

J Biomed Mater Res B Appl Biomater 2019 Feb 18. Epub 2019 Feb 18.

Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, M. Strzody 9 Street, 44-100 Gliwice, Poland.

Water-soluble polymer-methotrexate (MTX) conjugates were obtained via efficient carbodiimide-mediated amidation (E = 17-100%). Binding abilities between water-soluble V-shaped or star-shaped copolymers and MTX were studied by isothermal titration calorimetry spectroscopic (UV-vis, NMR) and microscopic (scanning electron microscopy and transmission electron microscopy) techniques. The efficiency of the amidation reaction has depended on the amount of pendant amino alcohol groups and zeta potential (ZP) values of polymeric carries. Read More

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http://dx.doi.org/10.1002/jbm.b.34338DOI Listing
February 2019

Glomerular filtration rate in patients with moderate to severe psoriasis.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Psoriasis could be associated to comorbidities that can affect kidney function, including diabetes mellitus, arterial hypertension and hyperuricaemia. Chronic kidney disease (CKD) affects up to 10.4% of patients with psoriasis , and it is a risk factor for renal failure, cardiovascular diseases and overall mortality. Read More

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http://doi.wiley.com/10.1111/jdv.15506
Publisher Site
http://dx.doi.org/10.1111/jdv.15506DOI Listing
February 2019
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Emerging role of immune cell network in autoimmune skin disorders: An update on pemphigus, vitiligo and psoriasis.

Cytokine Growth Factor Rev 2019 Feb 8. Epub 2019 Feb 8.

Department of Biochemistry, All India Institute of Medical Sciences, AIIMS, New Delhi, India. Electronic address:

Autoimmune skin diseases are a group of disorders that arise due to a deregulated immune system resulting in skin tissue destruction. In the majority of these conditions, either autoreactive immune cells or the autoantibodies are generated against self-antigens of the skin. Although the etiology of these diseases remains elusive, biochemical, genetic, and environmental factors such as infectious agents, toxins damage the skin tissue leading to self-antigen generation, autoantibody attack and finally results in autoimmunity of skin. Read More

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http://dx.doi.org/10.1016/j.cytogfr.2019.01.001DOI Listing
February 2019

Clinical significance and immunobiology of IL-21 in autoimmunity.

J Autoimmun 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, PR China. Electronic address:

Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the immune system, for example, by promoting proliferation and the development of Tfh and Th17 cells, balancing helper T cell subsets, inducing B cell generation and differentiation into plasma cells, and enhancing the production of immunoglobulin. These effects are mainly mediated by activation of the JAK/STAT, MAPK and PI3K pathways. Some IL-21 target genes, such as B lymphocyte induced maturation protein-1 (Blimp-1), suppressor of cytokine signaling (SOCS), CXCR5 and Bcl-6, play important roles in the immune response. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.013DOI Listing
February 2019
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Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on Psoriatic patches in albino rats.

Pak J Pharm Sci 2019 Jan;32(1):35-42

Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Psoriasis has become a topic of global concern because of consistency in its prevalence according to Global Report on Psoriasis 2016, however, till date, no therapy has provided complete cure of this disease and no useful measure was discovered to prevent it or eliminate the risk of its relapse. Hence, the present study was designed to evaluate anti-psoriatic effects of Spinacia oleracea due to its anti-inflammatory, anti-oxidant, anti-proliferative and skin-strengthening contents. Psoriasis was induced by oral potassium iodide solution which was then determined by two methods i. Read More

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January 2019

Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes.

Int Immunopharmacol 2019 Feb 14;69:328-336. Epub 2019 Feb 14.

Faculty of Medicine, University of Iceland, Biomedical Center, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland; Department of Immunology, Landspitali-The National University Hospital of Iceland, Bld 14 at Eiriksgata, IS-101 Reykjavik, Iceland; Center for Rheumatology Research, Landspitali-The National University Hospital of Iceland, Bld 14 at Eiriksgata, IS-101 Reykjavik, Iceland. Electronic address:

Regular bathing in the Blue Lagoon has beneficial effects on psoriasis. Previously, we showed that exopolysaccharides (EPS-Ca) secreted by Cyanobacterium aponinum, a dominating organism in the Blue Lagoon, increased IL-10 secretion by human dendritic cells (DCs). In addition, co-culturing allogeneic CD4 T cells with DCs matured in the presence of EPS-Ca increased differentiation of T cells into T regulatory cells at the cost of the disease inducing Th17 cells. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.044DOI Listing
February 2019

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.

J Am Acad Dermatol 2019 Feb 7. Epub 2019 Feb 7.

University of Alabama, Birmingham, Alabama.

Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations based on the available evidence. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.057DOI Listing
February 2019

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities.

J Am Acad Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Baylor Scott and White, Dallas, Texas.

Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available evidence. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.058DOI Listing
February 2019
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A comparison of apremilast monotherapy and combination therapy for psoriatic arthritis in a real life setting: data from the Leeds Combined Psoriatic Service.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK.

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http://dx.doi.org/10.1016/j.jaad.2019.02.014DOI Listing
February 2019
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A Summary of 2018 and What Lies Ahead for Dermatology and Therapy in 2019.

Dermatol Ther (Heidelb) 2019 Mar 15;9(1):1-3. Epub 2019 Feb 15.

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR BRC, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s13555-019-0283-4DOI Listing
March 2019
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Persistence and 4-year boosting of the bactericidal response elicited by two- and three-dose schedules of MenB-FHbp: A phase 3 extension study in adolescents.

Vaccine 2019 Feb 12. Epub 2019 Feb 12.

Pfizer Vaccine Research and Development, 500 Arcola Road, Collegeville, PA 19426, USA.

Background: The period of heightened risk of invasive meningococcal disease in adolescence extends for >10 years. This study aimed to evaluate persistence of the immune response to the serogroup B meningococcal (MenB) vaccine MenB-FHbp (Trumenba, Bivalent rLP2086) under two- and three-dose primary vaccination schedules, both of which are approved in the United States and the European Union, and to assess safety and immunogenicity of a booster dose.

Methods: This was an open-label extension study of a phase 2 randomized MenB-FHbp study (primary study). Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.073DOI Listing
February 2019
2 Reads

Eczematous eruption during anti-interleukin 17 treatment of psoriasis: an emerging condition.

Br J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.

Major advances in psoriasis pathogenesis gave rise to development of new effective drugs for its treatment. Particularly, biologic drugs revolutionized disease management. TNF-α inhibitors represented the opening available biologic class since 2000. Read More

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http://dx.doi.org/10.1111/bjd.17779DOI Listing
February 2019

General health status in psoriasis patients, as assessed by the SF-12 questionnaire, is poorly associated with PASI.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Clinical Epidemiology Unit, IDI-IRCCS, Rome, Italy.

An important issue in medicine is how to measure the clinical severity of a disease. In psoriasis this is traditionally assessed using the Psoriasis Area and Severity Assessment (PASI). However, it is a concern that this measure does not really capture the burden that the disease has on patients. Read More

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http://dx.doi.org/10.1111/jdv.15495DOI Listing
February 2019

Psoriasis and skin pain: real-life effectiveness of calcipotriol plus betamethasone dipropionate in aerosol foam formulation.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Advanced Biomedical Sciences, University of Naples "Federico II", Italy.

Background/objective: Although 40% of psoriasis patients reported skin pain, this symptom is often underestimated. A new formula of calcipotriol plus betamethasone dipropionate (Cal/BD) has been recently approved for psoriasis treatment. Therefore, we aimed to evaluate the efficacy of Cal/BD aerosol foam on skin pain of patients with plaque psoriasis. Read More

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http://dx.doi.org/10.1111/jdv.15488DOI Listing
February 2019

Tildrakizumab for psoriasis.

Authors:

Aust Prescr 2019 Feb 13;42(1):40-41. Epub 2018 Dec 13.

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https://www.nps.org.au/australian-prescriber/articles/tildra
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http://dx.doi.org/10.18773/austprescr.2018.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370602PMC
February 2019
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IL-17 and limits of success.

Cell Immunol 2018 Sep 17. Epub 2018 Sep 17.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address:

Interleukin-17 (IL-17) is a potent proinflammatory cytokine that protects a host against fungal and extracellular bacterial infections. On the other hand, excessive or dysregulated production of IL-17 underlines susceptibility to autoimmune disease. Consequently, blocking IL-17 has become an effective strategy for modulating several autoimmune diseases, including multiple sclerosis (MS), psoriasis, and rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.09.001DOI Listing
September 2018
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Dithranol-loaded nanostructured lipid carrier-based gel ameliorate psoriasis in imiquimod-induced mice psoriatic plaque model.

Drug Dev Ind Pharm 2019 Feb 14:1-13. Epub 2019 Feb 14.

a Department of Pharmaceutics , National Institute of Pharmaceutical Education & Research (NIPER) , Hyderabad , India ;

Objective: The aim of this study was to formulate nanostructured lipid carriers (NLCs) of dithranol-loaded in gel for ease of application and to evaluate its anti-psoriatic efficacy vis-a-vis conventional ointment formulation.

Significance: This study will provide an insight about the use of nanocarriers, esp. NLCs loaded with dithranol for the effective treatment of psoriasis. Read More

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http://dx.doi.org/10.1080/03639045.2019.1576722DOI Listing
February 2019
2.006 Impact Factor

Mycosis fungoides, Psoriasis und PD-1-Inhibitoren - neuer Aspekt einer bekannten Assoziation.

J Dtsch Dermatol Ges 2019 Feb;17(2):186-188

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1111/ddg.13715_gDOI Listing
February 2019
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Serum adropin levels in psoriasis vulgaris and its relation with metabolic parameters

Turk J Med Sci 2019 Feb 11;49(1):110-115. Epub 2019 Feb 11.

Background/aim: Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS).

Materials And Methods: Fifty-three patients and 26 healthy controls were included in this study. Read More

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http://dx.doi.org/10.3906/sag-1712-192DOI Listing
February 2019
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Long-term efficacy and safety of biosimilar infliximab (CT-P13) after switching from originator infliximab: Open-label extension of the NOR-SWITCH trial.

J Intern Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Rheumatology, Diakonhjemmet Hospital, Oslo.

Background And Objectives: The 52-week, randomized, double blind, non-inferiority, government funded NOR-SWITCH trial demonstrated that switching from infliximab originator to less expensive biosimilar CT-P13 was not inferior to continued treatment with infliximab originator. The NOR-SWITCH extension trial aimed to assess efficacy, safety and immunogenicity in patients on CT-P13 throughout the 78-week study period (maintenance group) vs patients switched to CT-P13 at week 52 (switch group).

Primary Outcome: disease worsening during follow-up based on disease specific composite measures. Read More

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http://dx.doi.org/10.1111/joim.12880DOI Listing
February 2019
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