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    1 OF 857

    Management of long-term therapy with biological drugs in psoriatic patients with latent tuberculosis infection in real life setting.
    Dermatol Ther 2017 May 26. Epub 2017 May 26.
    SC Dermatologia, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.
    Psoriatic patients with latent tuberculosis infection (LTBI) need a prophylaxis before starting a treatment with biological drugs. The aim of this study is to investigate the safety and efficacy of prophylaxis of LTBI in psoriatic patients receiving long-term biological drugs. The study included 56 patients (42 male and 14 female) affected by moderate-to-severe psoriasis (mean PASI: 12. Read More

    Guttate psoriasis triggered by perianal streptococcal infection.
    Clin Exp Dermatol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, University Medical Center Utrecht, Wilhelmina Children's Hospital, the Netherlands.
    The association of guttate psoriasis (GP) with streptococcal pharyngitis is well accepted. However, less is known about the association with perianal streptococcal infection. We report a case of a 19-month-old boy with GP after a preceding perianal streptococcal dermatitis, with no clinical signs of a streptococcal pharyngitis. Read More

    Secukinumab improves psoriasis symptoms in patients with inadequate response to cyclosporine A: A prospective study to evaluate direct switch.
    J Dermatol 2017 May 23. Epub 2017 May 23.
    The Jikei University School of Medicine, Tokyo, Japan.
    There are limited data on the safety and efficacy of switching to secukinumab from cyclosporine A (CyA) in patients with psoriasis. The purpose of the present study was to assess the efficacy and safety of secukinumab for 16 weeks after direct switching from CyA in patients with moderate-to-severe psoriasis. In this multicenter, open-label, phase IV study, 34 patients with moderate-to-severe psoriasis and inadequate response to CyA received secukinumab 300 mg s. Read More

    Psoriasis in those planning a family, pregnant or breast-feeding. The Australasian Psoriasis Collaboration.
    Australas J Dermatol 2017 May 23. Epub 2017 May 23.
    Holdsworth House Medical Practice, Sydney, New South Wales, Australia.
    The Australasian Psoriasis Collaboration has reviewed the evidence for managing moderate to severe psoriasis in those who are pregnant or are breast-feeding, or planning a family. The severity of the psoriasis, associated comorbidities and specific anti-psoriasis treatment, along with other exposures, can have a deleterious effect on pregnancy outcomes. Psoriasis itself increases the risk of preterm and low birthweight babies, along with spontaneous and induced abortions, but no specific birth defects have been otherwise demonstrated. Read More

    Comparison of ixekizumab with ustekinumab in moderate-to-severe psoriasis: 24-week results from IXORA-S, a Phase 3 study.
    Br J Dermatol 2017 May 19. Epub 2017 May 19.
    Dermatology Department, CHU, Paul Sabatier University, Toulouse, France.
    Background: The interleukin (IL)-23/IL-17 axis has been shown critical in the pathogenesis of psoriasis.

    Objectives: To present the primary endpoint (Week 12) and safety/efficacy data up to Week 24 from a head-to-head trial (IXORA-S) of the IL-17A inhibitor, ixekizumab (IXE), vs. the IL-12/23 inhibitor ustekinumab (UST). Read More

    Integrative analyses reveal biological pathways and key genes in psoriasis.
    Br J Dermatol 2017 May 25. Epub 2017 May 25.
    Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.
    Background: Psoriasis is a complex disease that is influenced by both genetic and environmental factors with abnormal gene expression in lesional skin. However, no studies are available on genome-scale gene expression of psoriatic lesions in the Chinese population. In addition, systematic studies on the biological pathways, pathogenicity and interaction networks of psoriasis-related genes with abnormal expression profiles require further investigation. Read More

    Web app based patient education in psoriasis - a randomized controlled trial.
    Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.
    Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
    Purpose: Patients report wanting more information about psoriasis and clear expectations from the onset of therapy. Dermatologists do not think patients receive or internalize adequate information. There isa need for further explanation of treatment regimens to increase knowledge, compliance, and patient satisfaction. Read More

    Palmoplantar pustulosis - a cross-sectional analysis in Germany.
    Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.
    Department of Dermatology and Allergology, University Bonn, Germany.
    Background: Palmoplantar pustulosis (PPP) is a recalcitrant chronic inflammatory skin disease. Data relevant for the medical care of patients with PPP are scarce. Thus, the aim of this work was to investigate the disease burden, clinical characteristics, and comorbidity of PPP patients in Germany. Read More

    The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade.
    Rheumatology (Oxford) 2017 May 24. Epub 2017 May 24.
    Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.
    In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal. Read More

    Residual disease activity in psoriatic arthritis: discordance between the rheumatologist's opinion and minimal disease activity measurement.
    Rheumatology (Oxford) 2017 May 24. Epub 2017 May 24.
    Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam.
    Objective.: To assess how many PsA patients with an acceptable disease state according to the treating rheumatologist have quiescent disease defined as minimal disease activity (MDA).

    Methods. Read More

    Psychological parameters of psoriasis.
    Psychiatriki 2017 Jan-Mar;28(1):54-59
    2nd Department of Psychiatry, "Attikon" General Hospital, Athens University Medical School, Athens, Greece.
    Psoriasis is a chronic, inflammatory scaling dermatosis. The marked visible appearance of the lesions have a negative impact on body image that leads to decreased self-esteem, hence seriously compromising the patient's quality of life. The clinical picture critically affects the social well-being of the patient since the disease is commonly misunderstood and feared by the social environment as being contagious. Read More

    Atorvastatin as adjunctive therapy for chronic plaque type psoriasis versus betamethasone valerate alone: A randomized, double-blind, placebo-controlled trial.
    Indian J Dermatol Venereol Leprol 2017 May 23. Epub 2017 May 23.
    Department of Medicine, Section of Dermatology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
    Background: Psoriasis is a T helper 1 cell-mediated chronic inflammation. Statins have been found to have anti-inflammatory and immunomodulatory effects targeting T helper 1 cells and thus, are being investigated as treatments for psoriasis.

    Aims: To investigate the efficacy and safety of atorvastatin as adjunctive treatment for mild to moderate chronic plaque psoriasis; and the impact of atorvastatin on quality of life. Read More

    Pediatric Psoriasis.
    Am J Clin Dermatol 2017 May 24. Epub 2017 May 24.
    Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
    Psoriasis is a chronic inflammatory systemic disease associated with an important physical and physiological burden. It primarily affects the skin, but it is associated with several serious medical co-morbidities. One third of total psoriatic cases have their onset during the pediatric age, although some of them may not be diagnosed until the patient reaches adulthood. Read More

    Methicillin Resistant Staphylococcus Aureus Sacroiliac Joint Septic Arthritis in an Adult Patient Treated with Daptomycin.
    J Bone Jt Infect 2017 5;2(3):143-148. Epub 2017 Apr 5.
    Department of Orthopaedics and Traumatology, Royal Blackburn Hospital, Haslingden Road, Blackburn BB2 3HH.
    Sacroiliac joint septic arthritis is a rare disease entity representing 1-2% of all cases of septic arthritis. Establishment of the diagnosis is often challenging given the non-specific presenting features and the potential cross-over with other pathologies. We report the case of a 50 year old gentleman who suffers with psoriasis and presented with sacroiliac joint septic arthritis complicated by Methicillin Resistant Staphylococcus Aureus (MRSA) bacteraemia and an iliopsoas abscess. Read More

    Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation.
    Mediators Inflamm 2017 30;2017:6541729. Epub 2017 Apr 30.
    Medical Research Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
    A growing body of literature suggests that most chronic autoimmune diseases are associated with inappropriate inflammation mediated by Toll-like receptor (TLR) 3, TLR7/8, or TLR9. Therefore, research into blocking TLR activation to treat these disorders has become a hot topic. Here, we report the immunomodulatory properties of a nonstimulatory CpG-containing oligodeoxynucleotide (CpG-ODN), CpG-c41, which had previously only been known as a TLR9 antagonist. Read More

    Results from Polish Spondyloarthritis Initiative registry (PolSPI) - methodology and data from - the first year of observation.
    Reumatologia 2017 28;55(2):59-64. Epub 2017 Apr 28.
    Department of Rheumatology, Jagiellonian University Medical College, Krakow, Poland.
    Objectives: Report on one-year results from the Polish Spondyloarthritis Initiative registry (PolSPI), containing the cross-sectional analysis of clinical and imaging data as well as database methodology.

    Material And Methods: The PolSPI registry includes patients with axial (axSpA) and peripheral (perSpA) spondyloarthritis according to ASAS classification criteria, and/or patients with ankylosing spondylitis according to modified New York criteria, psoriatic arthritis according to CASPAR criteria, arthropathy in inflammatory bowel disease, reactive arthritis, juvenile spondyloarthritis or undifferentiated spondyloarthritis. Epidemiologic data and history of signs, symptoms and treatment of spondyloarthritis are collected and assessment of disease activity is performed. Read More

    Glycemic Control in the Treatment of Psoriasis.
    Dermatology 2017 May 25. Epub 2017 May 25.
    School of Medicine, Department of Medicine, Queen's University, Kingston, ON, Canada.
    Psoriasis is a common chronic inflammatory skin disease that manifests as scaly erythematous plaques as a consequence of keratinocyte hyperproliferation and inflammation. It is commonly associated with diabetes, obesity, and the metabolic syndrome. While there are numerous approved treatment options available, they have limitations including availability, toxicities such as immunosuppression, and high cost. Read More

    Leishmanial dactylitis: an unusual clinical presentation.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Cutaneous leishmaniasis (CL) is one of the most common endemic diseases in Iran. It has a diverse spectrum of clinical manifestations. Herein we present a woman with leishmanial dactylitis, which is a very rare clinical form of CL. Read More

    Psoriasis mimicking mycosis fungoides clinically.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Creighton University School of Medicine, Omaha, Nebraska.
    Psoriasis is a complex, chronic immune-mediated inflammatory disease that most commonly presents as well-demarcated erythematous plaques with micaceous scale, affecting roughly 3-4% of the US population [1-4]. Clinically, lesions are often well demarcated thick, scaly, erythematous plaques, characteristically located on the extensor surfaces, such as elbows and knees [1]. In most cases, clinical impression is sufficient to diagnose psoriasis. Read More

    Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California.
    Despite characteristic features, psoriasis can mimic other dermatologic conditions, such as seborrheic dermatitis, lichen simplex chronicus, and certain nutritional deficiencies such as pellagra. We present a patient with a longstanding history of severe plaque psoriasis who presented with disfiguring scaly plaques involving greater than 80% body surface area. The patient's disease was minimally responsive to multiple therapies. Read More

    Use of an oral phosphodiesterase-4 inhibitor (apremilast) for the treatment of chronic, severe atopic dermatitis: a case report.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    University of Vermont College of Medicine, Burlington, Vermont.
    Atopic dermatitis (AD) is a common inflammatory dermatosis characterized by pruritus, erythema, induration, and lichenification. Current treatment options for generalized atopic dermatitis are limited and have potentially serious adverse effects, especially in patients with severe, chronic AD who frequently require systemic anti-inflammatory agents. Apremilast, an oral phosphodiesterase-4 inhibitor, was FDA approved in September 2014 for the treatment of moderate-to-severe plaque psoriasis. Read More

    Global skin diseases on Instagram hashtags.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, Dermatology Service, Eastern Colorado Health Care System, US Department of Veteran Affairs, Denver, Colorado.
    Recently named one of the most influential phone applications, Instagram continues to grow in popularity [1]. Instagram consists of images and video posts, making it ideal for education and communication within the visual field of dermatology. In this study, we seek to determine the presence of dermatology-related content with regard to the most common cutaneous diseases of the world. Read More

    Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.
    Nat Commun 2017 May 24;8:15382. Epub 2017 May 24.
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
    Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Read More

    Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: a review of 19 cases.
    J Neurol 2017 May 23. Epub 2017 May 23.
    Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital Tilburg, Tilburg, The Netherlands.
    Progressive multifocal leukoencephalopathy (PML) is a rare and potentially fatal condition caused by a brain infection with JC polyomavirus (JCV). PML develops almost exclusively in immunocompromised patients and has recently been associated with use of fumaric acid esters (FAEs), or fumarates. We reviewed the literature and the Dutch and European pharmacovigilance databases in order to identify all available FAE-associated PML cases and distinguish possible common features among these patients. Read More

    Alexithymia, Illness Perception and Self-management Competency in Psoriasis.
    Acta Derm Venereol 2017 May 24. Epub 2017 May 24.
    Department of Health Sciences, Institute of Health and Society, Medical Faculty, University of Oslo, Oslo, Norway.
    Alexithymia, defined as difficulty in describing or recognizing emotions, has been shown to be connected with psoriasis, but its relationship with self-management of psoriasis has not been explored. The aim of this study was to assess the frequency of alexithymia and its relationship with self-management and illness perception in the context of psoriasis. A total of 163 patients participating in 3 weeks of climate heliotherapy (CHT) at Gran Canaria were assessed for alexithymia using the Toronto Alexithymia Scale (TAS-20) at baseline. Read More

    Increased risks of venous thromboembolism in patients with psoriasis. A Nationwide Cohort Study.
    Thromb Haemost 2017 May 24. Epub 2017 May 24.
    Wei-Sheng Chung, MD, PhD, Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan, No. 199, Section 1, San-Min Road, Taichung City 40343, Taiwan, Tel.: +886 4 22294411, Fax: +886 4 22290020, E-mail:
    Systemic inflammation and hypercoagulability in psoriasis are related to cardiovascular morbidity. The aim of the study was to investigate the incidence and risk of venous thromboembolism (VTE) in patients with psoriasis in Taiwan. We identified inpatients aged ≥ 18 years with a diagnosis of psoriasis and controls at a 1: 1 ratio of frequency matched by sex, age, frequency of medical visits, length of stay, and comorbidities between 2000 and 2010 in the Taiwan National Health Insurance Research Database. Read More

    Short- and Long-Term Management of an Acute Pustular Psoriasis Flare: A Case Report.
    J Cutan Med Surg 2017 May 1:1203475417712499. Epub 2017 May 1.
    2 Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
    Background: Generalised pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH) are chronic, relapsing variants of pustular psoriasis proven to be remarkably challenging to treat. Due to their uncommon presentation, there are few described cases in literature and scarce evidence for management. Further information is needed to help dermatologists formulate treatment plans for patients presenting with such diseases. Read More

    Pharmacophore guided discovery of small-molecule interleukin 15 inhibitors.
    Eur J Med Chem 2017 May 12;136:543-547. Epub 2017 May 12.
    Department of Immunology, Biochemistry and Nutrition, Centre for Preclinical Research and Technologies, Medical University of Warsaw, S. Banacha1b, 02-097 Warsaw, Poland. Electronic address:
    Upregulation of interleukin 15 (IL-15) contributes directly i.a. to the development of inflammatory and autoimmune diseases. Read More

    Biomarkers for psoriasis skin lesions.
    G Ital Dermatol Venereol 2017 May 23. Epub 2017 May 23.
    Dermatology Unit, Livorno Hospital, Livorno, Italy.
    Psoriasis is a common, chronic skin disease, whose diagnosis is based mainly on clinical features but, in some cases, can be difficult. As the exact diagnosis of psoriasis and the differential diagnosis with other diseases is crucial for the diagnosis and the therapeutic choice, several studies investigated the relevance of some genes and proteins as potential specific skin biomarkers. Despite a large number of studies, none of them has been tested in large studies and thus achieved regulatory approval and clinical application. Read More

    The management of moderate-to-severe chronic plaque psoriasis.
    G Ital Dermatol Venereol 2017 May 23. Epub 2017 May 23.
    Dermatology Department, University of Pisa, Pisa, Italy -
    Recent approval and marketization of novel treatments have widened the range of therapeutic opportunities for moderate-to-severe psoriasis. In the next years, this panorama will be further enlarged as many other agents, both oral small molecules and biologics, have passed phase III and are expected to be approved, and subsequently marketed, shortly. In spite of this array of therapeutic possibilities, there is still an unmet need for an appropriate treatment in a large number of cases. Read More

    Management of psoriatic arthritis (PsA) among cutaneous psoriasis: from pathogenesis to therapy.
    G Ital Dermatol Venereol 2017 May 23. Epub 2017 May 23.
    Department of Dermatology, Edouard Herriot Hospital, Claude Bernard Lyon I University, Lyon, France -
    Psoriatic arthritis (PsA) is an inflammatory rheumatism belonging to spondylarthritis family and which occurs in about 30% of patients with psoriasis. The pathogenesis entails a genetic predisposition, environmental and immunologic factors. Most of the time, cutaneous lesions precede apparition of articular manifestations and dermatologists who treat psoriatic patients have to regularly screen for early PsA, especially in patients with risk factors (notably nail psoriasis). Read More

    Association Between Inflammatory Skin Disease and Cardiovascular and Cerebrovascular Co-Morbidities in US Adults: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Psoriasis, atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis are chronic inflammatory skin disorders associated with systemic immune activation, considerable symptom burden, stigma, functional disturbances, and mental health symptoms. All of these might increase cardiovascular risk.

    Objective: The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease. Read More

    Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin.
    AAPS J 2017 May 22. Epub 2017 May 22.
    Pfizer Medicine Design, Groton, Connecticut, USA.
    Interleukin 17 is a family of cytokines that play a central role in many autoimmune and inflammatory diseases. IL-17A has been implicated as a key driver of psoriasis, mediating a chronic cycle of T-cell activation, keratinocyte proliferation and angiogenesis. It has been hypothesized that expression of IL-17A and the related cytokine IL-17F could be used as predictive biomarkers for therapeutic response, though they have been difficult to measure locally or in circulation because of their low abundance. Read More

    IL-23/Th17 targeted therapies in SAPHO syndrome. A case series.
    Joint Bone Spine 2017 May 19. Epub 2017 May 19.
    Department of Rheumatology, CHRU de Besançon, and Université Bourgogne Franche-Comté, 25030 Besançon, France.
    SAPHO syndrome is a rare entity with skin and rheumatologic inflammatory presentation. The treatment is not standardized, and in case of inadequate response to anti inflammatory drugs, the use of anti TNF or anti IL-1 biologic treatments has been reported. The IL-23/Th17 axis may be involved in SAPHO syndrome. Read More

    A Case of Advanced Unicentric Retroperitoneal Castleman's Disease, Associated With Psoriasis.
    Acta Med Iran 2017 Apr;55(4):277-279
    Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Center, Tehran University of Medical Sciences, Tehran, Iran.
    We present here a 32-year-old male with advanced lately diagnosed, right sided retroperitoneal mass, which had been already treated due to progressive muco-cutaneous lesions clinically consistent with psoriasis, during recent four years. The advanced retroperitoneal mass resected surgically and reported as hyaline-vascular castleman disease with a dense focus of coarse calcification, on histopathology. Association of psoriasis and castlman disease is discussed in this case report. Read More

    TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis.
    Nat Commun 2017 May 22;8:15395. Epub 2017 May 22.
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.
    Atopic dermatitis (AD) and psoriasis are driven by alternate type 2 and type 17 immune responses, but some proteins might be critical to both diseases. Here we show that a deficiency of the TNF superfamily molecule TWEAK (TNFSF12) in mice results in defective maintenance of AD-specific T helper type 2 (Th2) and psoriasis-specific Th17 cells in the skin, and impaired expression of disease-characteristic chemokines and cytokines, such as CCL17 and TSLP in AD, and CCL20 and IL-19 in psoriasis. The TWEAK receptor, Fn14, is upregulated in keratinocytes and dermal fibroblasts, and TWEAK induces these cytokines and chemokines alone and in synergy with the signature T helper cytokines of either disease, IL-13 and IL-17. Read More

    Harefuah 2016 Oct;155(10):600-603
    Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel.
    Introduction: TNFα-targeted therapies have emerged as a new class of drugs in the treatment of various inflammatory diseases, including psoriasis. With the increasing use and longer follow-up periods of TNFα targeted therapies, a spectrum of immunological adverse events have been described, ranging from asymptomatic immunological alterations to life-threatening systemic diseases such as pulmonary fibrosis. We present a case of a 66 year old man diagnosed with psoriasis who developed pulmonary fibrosis three years after initiation of Etanercept (Enbrel) for his skin disease. Read More

    Evolution, immunity and the emergence of brain superautoantigens.
    F1000Res 2017 21;6:171. Epub 2017 Feb 21.
    Bank of Tissues and Cells, Lyon University Hospital (Hospices Civils de Lyon), CarMeN Laboratory, INSERM 1060, INRA 1397, INSA Lyon, Université Claude Bernard Lyon-1, Lyon, F-69000, France.
    While some autoimmune disorders remain extremely rare, others largely predominate the epidemiology of human autoimmunity. Notably, these include psoriasis, diabetes, vitiligo, thyroiditis, rheumatoid arthritis and multiple sclerosis. Thus, despite the quasi-infinite number of "self" antigens that could theoretically trigger autoimmune responses, only a limited set of antigens, referred here as superautoantigens, induce pathogenic adaptive responses. Read More

    Fixed-Combination Calcipotriene Plus Betamethasone Dipropionate Aerosol Foam Is Well Tolerated in Patients with Psoriasis Vulgaris: Pooled Data from Three Randomized Controlled Studies.
    Skinmed 2017 1;15(2):119-124. Epub 2017 Apr 1.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.
    The authors performed a pooled analysis of three randomized, 4-week, phase II/III studies in adult patients with mild to severe psoriasis and assessed the safety/tolerability of aerosol foam fixed-combination calcipotriene 0.005% (Cal) plus betamethasone dipropionate 0.064% (BD) versus different comparators. Read More

    Assessment of the psychometric properties of the EQ-5D-3L and EQ-5D-5L instruments in psoriasis.
    Arch Dermatol Res 2017 May 20. Epub 2017 May 20.
    Social Policy and Health Economics, School of Economics and Political Sciences, University of Athens, 6 Themistokleous Street, 106 78, Athens, Greece.
    The aim of this study was to assess the psychometric properties of the five-level (EQ-5D-5L) in comparison with the standard three-level (EQ-5D-3L) classification systems of the EQ-5D in a sample of psoriatic patients. Psoriatic subjects (n = 396) recruited from 16 private practicing centers from various areas of Greece self-completed the two EQ-5D versions and the Dermatology Life Quality Index, while information was also collected on socio-demographics, clinical characteristics and comorbidities. The EQ-5D-5L and EQ-5D-3L were evaluated in terms of agreement, feasibility, ceiling effects, redistribution properties, inconsistency, informativity, and convergent and known-groups validity. Read More

    Income disparities in healthcare use remain after controlling for healthcare need: evidence from Swedish register data on psoriasis and psoriatic arthritis.
    Eur J Health Econ 2017 May 19. Epub 2017 May 19.
    Health Technology Assessment Skåne, Skåne University Hospital, Lund, Sweden.
    We used a southern Swedish cohort of psoriasis (PSO) and psoriatic arthritis (PsA) patients and population-based referents (N = 57,800) to investigate the influence of socioeconomic and demographic factors on the probability of healthcare use and on healthcare costs when controlling for need as measured by PSO/PsA and common additional morbidities such as diabetes, depression and myocardial infarction. People with PSO/PsA were identified by ICD-10 codes in the Skåne Healthcare Register 1998-2007. Resource use and costs for years 2008-2011 were retrieved from the Skåne Healthcare Register and the Swedish Prescribed Drug Register, and socioeconomic data were retrieved from Statistics Sweden. Read More

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