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    Effect of Different Skin Penetration Promoters in Halobetasol Propionate Permeation and Retention in Human Skin.
    Int J Mol Sci 2017 Nov 21;18(11). Epub 2017 Nov 21.
    Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
    Halobetasol propionate (HB) is a potent synthetic corticosteroid used against inflammatory skin diseases, such as dermatitis, eczema, and psoriasis, among others. The aim of this study is to define how the presence of different skin penetration enhancers (nonane, menthone, limonene, azone, carene, decanol, linoleic acid and cetiol) affects the penetration and retention in skin of HB. To determine drug penetration through skin, 5% of each promoter was used in an ex vivo system with human skin on Franz cells. Read More

    Increased risk of periodontitis in patients with psoriatic disease: a nationwide population-based retrospective cohort study.
    PeerJ 2017 16;5:e4064. Epub 2017 Nov 16.
    Department of Periodontics, Chung Shan Medical University Hospital, Taichung, Taiwan.
    Aims: Periodontitis and psoriatic disease, including psoriasis (PS) and psoriatic arthritis (PsA), share the common risk factors and co-morbidities. However, the risk of periodontitis in patients with psoriatic disease still needs further investigation. This study was a nationwide population-based retrospective cohort study assessing the risk of periodontitis from psoriatic disease exposure. Read More

    Tethering Interleukin-22 to Apolipoprotein A-I Ameliorates Mice from Acetaminophen-induced Liver Injury.
    Theranostics 2017 26;7(17):4135-4148. Epub 2017 Sep 26.
    Department of Microbiological and Biochemical Pharmacy & The Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P. R. China.
    Increasing evidence indicates that interleukin-22 (IL-22) holds tremendous potential as a protective agent in preventing liver injury, but its pleiotropic effects and pathogenic role in carcinogenesis, rheumatoid arthritis and psoriasis restrict its systemic application. Here, we first developed a nanoparticle (liposIA) as a liver-targeted agent through IL-22 tethered to apolipoprotein A-I (ApoA-I) in a gene therapy vector. LiposIA was prepared using thin film dispersion method and the complexes exhibited desirable nanoparticle size, fine polydisperse index, highly efficient transfection, and excellent serum and storage stability. Read More

    RNase 7 strongly promotes TLR9-mediated DNA sensing by human plasmacytoid dendritic cells.
    J Invest Dermatol 2017 Nov 17. Epub 2017 Nov 17.
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Germany.
    Plasmacytoid dendritic cells (pDCs) were described to accumulate in the skin of patients with psoriasis and to be recruited into the dermis upon allergen challenge in atopic dermatitis. Importantly, activation of pDCs in the skin has been identified as important initiator of psoriasis development. RNase 7 is one of the major antimicrobial peptides (AMP) secreted by keratinocytes and is expressed in significantly higher amounts in lesional skin of patients with atopic dermatitis or psoriasis than in healthy individuals. Read More

    Advanced Glycation End Products in the Pathogenesis of Psoriasis.
    Int J Mol Sci 2017 Nov 20;18(11). Epub 2017 Nov 20.
    Section of Dermatology, Department of Medicine, University of Verona, 37126 Verona, Italy.
    Advanced glycation end products (AGEs) are extremely oxidant and biologically reactive compounds, which form through oxidation of sugars, lipids and amino acids to create aldehydes that bind covalently to proteins. AGEs formation and accumulation in human tissues is a physiological process during ageing but it is enhanced in case of persistent hyperglycemia, hyperlipidemia and oxidative or carbonyl stress, which are common in patients with moderate to severe psoriasis. Exogenous AGEs may derive from foods, UV irradiation and cigarette smoking. Read More

    Survivin and autoimmunity; the ins and outs.
    Immunol Lett 2017 Nov 16. Epub 2017 Nov 16.
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran; Rheumatology Expert Group (REG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:
    Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Read More

    Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17.
    Pharmacol Res 2017 Nov 14. Epub 2017 Nov 14.
    Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China. Electronic address:
    DZ2002, a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor with immunosuppressive properties and potent therapeutic activity against various autoimmune diseases in mice. The present study was designed to characterize the potential therapeutic effects of DZ2002 on murine model of psoriasis and reveal the correlated mechanisms. In this report, we demonstrated that in vitro, DZ2002 significantly decreased the expression of pro-inflammatory cytokines and adhesion molecule including IL-1α, IL-1β, IL-6, IL-8, TNF-α and ICAM-1 by inhibiting the phosphorylation of p38 MAPK, ERK and JNK in TNF-α/IFN-γ-stimulated HaCaT human keratinocytes. Read More

    Interleukin-17 Alters the Biology of Many Cell Types Involved in the Genesis of Psoriasis, Systemic Inflammation, and Associated Comorbidities.
    Exp Dermatol 2017 Nov 20. Epub 2017 Nov 20.
    Laboratory of Investigative Dermatology, The Rockefeller University, New York, NY, USA.
    Psoriasis is a chronic, immune-mediated, systemic inflammatory disease that is defined by a characteristic skin reaction produced when elevated levels of inflammatory cytokines such as interleukin (IL)-17 alter the growth and differentiation of skin cells. The pathogenesis of comorbid conditions associated with psoriasis, including psoriatic arthritis, cardiovascular disease, obesity, metabolic syndrome, liver disorders, renal disease, and depression are also largely affected by inflammation. In this review, we examine the effect of IL-17 on the inflammatory pathways in a variety of different cell types, including keratinocytes, as well as epithelial cells of the colon, kidney, gut, and liver. Read More

    Automatic psoriasis lesion segmentation in two-dimensional skin images using multiscale superpixel clustering.
    J Med Imaging (Bellingham) 2017 Oct 10;4(4):044004. Epub 2017 Nov 10.
    University of Melbourne, Department of Electrical and Electronic Engineering, Victoria, Australia.
    Psoriasis is a chronic skin disease that is assessed visually by dermatologists. The Psoriasis Area and Severity Index (PASI) is the current gold standard used to measure lesion severity by evaluating four parameters, namely, area, erythema, scaliness, and thickness. In this context, psoriasis skin lesion segmentation is required as the basis for PASI scoring. Read More

    Molecular Modeling of Cloned Bacillus subtilis Keratinase and Its Insinuation in Psoriasis Treatment Using Docking Studies.
    Indian J Microbiol 2017 Dec 26;57(4):485-491. Epub 2017 Sep 26.
    Amity Institute of Microbial Biotechnology, Amity University Uttar Pradesh, Sector-125, Noida, U.P. India.
    Present study demonstrated the expression of cloned Bacillus subtilis RSE163 keratinase gene and in silico binding affinities of deduced protein with psoriasis topical drugs for systemic absorption and permeation through skin. The ker gene expressed in E. coli showed significantly higher keratinase activity 450 ± 10. Read More

    Instruments to assess stigmatization in dermatology.
    Postepy Hig Med Dosw (Online) 2017 Nov;71(0):901-905
    Department of Dermatology, Venereology and Allergology, University of Medicine, Wroclaw, Poland.
    Stigmatization is the assignment of negative perceptions to an individual because of a perceived difference from the population at large. Skin conditions are frequently the reason of social rejection with a consequent negative influence on the personal and social life of patients. The aim of the current study was to review the available instruments that can be successfully utilized to measure the stigmatization level among dermatological patients. Read More

    A Phase I Randomised Controlled Trial to Evaluate Safety and Clinical Effect of Topically Applied GSK2981278 Ointment in a Psoriasis Plaque Test.
    Br J Dermatol 2017 Nov 18. Epub 2017 Nov 18.
    GlaxoSmithKline, Collegeville, PA, USA.
    RORγt, a truncated isoform of retinoic acid receptor-related orphan receptor gamma (RORγ), is a transcription factor involved in Th17 cell differentiation. It is expressed in a few distinct types of immune cells and described as the master regulator of Th17 cytokine expression(1) . RORγ has identical ligand-binding domains as RORγt(2) ; consequently, compounds targeting RORγ are also expected to modulate Th17 cell activity. Read More

    Liver fibrosis is associated with cutaneous inflammation in the imiquimod-induced murine model of psoriasiform dermatitis.
    Br J Dermatol 2017 Nov 18. Epub 2017 Nov 18.
    Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, University of Poitiers, France.
    Background: Psoriasis associates several extra-cutaneous manifestations. Little is known about hepatic parameters specifically associated with psoriasis.

    Objective: To study whether psoriasiform dermatitis is associated with liver injury. Read More

    Essential Role of CARD14 in Murine Experimental Psoriasis.
    J Immunol 2017 Nov 17. Epub 2017 Nov 17.
    Laboratory of Adjuvant Innovation, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan;
    Caspase recruitment domain family member 14 (CARD14) was recently identified as a psoriasis-susceptibility gene, but its immunological role in the pathogenesis of psoriasis in vivo remains unclear. In this study, we examined the role of CARD14 in murine experimental models of psoriasis induced by either imiquimod (IMQ) cream or recombinant IL-23 injection. In all models tested, the psoriasiform skin inflammation was abrogated in Card14(-/-) mice. Read More

    Cardiovascular Risk in Psoriasis: Current State of the Art.
    Curr Vasc Pharmacol 2017 Nov 16. Epub 2017 Nov 16.
    University of Messina. Italy.
    Psoriasis (Pso) is a chronic inflammatory immune-mediated skin disease associated with several comorbidities. Despite the growing number of studies providing evidence for the link between Pso and cardiovascular (CV) disorders, there are still many unsolved questions, dealing with the role of the skin disease as an independent risk factor for CV events, the influence of Pso severity and duration on CV damage, the presence of psoriatic arthritis (PsA) as a predictor of increased CV mortality and morbidity and the detection of reliable clinical, laboratory and/or instrumental parameters to stratify CV risk in psoriatic patients. Moreover, it remains to clarify if the early treatment of the dermatosis may lower CV risk. Read More

    A validation study of the Simple Psoriatic Arthritis Screening (SiPAS) questionnaire to screen psoriasis patients for psoriatic arthritis.
    Clin Exp Rheumatol 2017 Nov 16. Epub 2017 Nov 16.
    Dermatological Clinic, Università Politecnica delle Marche, Ancona, Italy.
    Objectives: To validate in a multicentric cohort of patients a self-administered PsA screening tool, called Simple Psoriatic Arthritis Screening (SiPAS) questionnaire, to screen psoriasis patients for signs and symptoms of PsA.

    Methods: The SiPAS questionnaire was validated in a multicentric Italian cohort of psoriasis patients referred to two rheumatological centres.

    Results: A total of 202 psoriasis patients were screened with SiPAS in the validation study. Read More

    Th17 gene expression in psoriatic arthritis synovial fluid and peripheral blood compared to osteoarthritis and cutaneous psoriasis.
    Clin Exp Rheumatol 2017 Nov 9. Epub 2017 Nov 9.
    University of Toronto Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; Division of Rheumatology, Dept. of Medicine; Institute of Medical Science, University of Toronto, Canada.
    Objectives: The IL-23/IL-17 axis is central to the pathogenesis of psoriatic arthritis (PsA). We aimed to identify Th17 signalling genes that are dysregulated in synovial fluid of PsA compared to osteoarthritis (OA) patients and to determine if differences in peripheral blood can distinguish PsA from psoriasis patients and controls.

    Methods: Synovial fluid cells (SFCs) from 14 PsA and 9 OA patients were obtained and stored in TRIzol reagent. Read More

    A Case of Psoas Abscess after Robotic-Assisted Laparoscopic Hysterectomy and Pelvic Lymphadenectomy.
    J Minim Invasive Gynecol 2017 Nov 13. Epub 2017 Nov 13.
    Director of Division and Fellowship, Minimally Invasive Gynecologic Surgery and Robotics: NYU Winthrop Hospital; Clinical Professor of Obstetrics and Gynecology: Weill Cornell Medical College, Cornell University; Adjunct Professor of Obstetrics, Gynecology and Reproductive Medicine: School of Medicine, Stony Brook University. Electronic address:
    Iliopsoas abscess (IPA) is a rare condition seen in a variety of specialties that presents with nonspecific complaints. Presented herein is the development of an IPA after robotic staging with sentinel lymaphadenectomy for endometrial carcinoma. Patient is a 61yo female with history of prolonged immunosuppressive therapy due to psoriasis. Read More

    [Psoriatic arthritis in France, from infants to the elderly: Findings from two cross-sectional, multicenter studies].
    Ann Dermatol Venereol 2017 Nov 13. Epub 2017 Nov 13.
    Service de dermatologie et médecine vasculaire, hôpital Victor-Dupouy, 69, rue du Lieutenant-Colonel-Prud'hon, 95100 Argenteuil, France. Electronic address:
    Background: Psoriatic arthritis affects 20-30% of patients with psoriasis. Few epidemiological data are available in France about its prevalence and its association with skin lesions and comorbidities.

    Objectives: To assess the epidemiological aspects and the risk factors for psoriatic arthritis in children and adults in France. Read More

    TNF Antagonists: Killing Two "Birds" with one Biologic "Stone".
    Arthritis Rheumatol 2017 Nov 16. Epub 2017 Nov 16.
    Division of Rheumatology, Department of Medicine of the Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Forty years have passed since it was first recognized that patients with autoimmune rheumatic disease have an increased risk of fatal and non-fatal cardiovascular (CV) events (1) Although initial reports focused on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), similar findings were verified subsequently in patients with psoriasis (Ps) and/or psoriatic arthritis (PsA) and spondyloarthritis. An early feature of the atherosclerotic lesion is infiltration with inflammatory cells, particularly monocytes/macrophages, and the presence of these cells in mature plaque elevates the risk of plaque rupture and thrombosis (2). In the general population, modest elevations of circulating inflammatory proteins, including C-reactive protein (CRP), interleukin-6 (IL-6) and soluble endothelial adhesion proteins, are associated with an increased risk of acute CV events (3). Read More

    The association of genetic variants in chemokine genes with the risk of psoriasis vulgaris in Chinese population: A case-control study.
    Medicine (Baltimore) 2017 Nov;96(46):e8283
    aDepartment of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing bDepartment of Dermatology, Attached Hospital, Jiujiang University, Jiujiang, China.
    This study aimed to investigate the influence of polymorphisms in chemokine genes, including MCP1, CCR2, and CCR5 with psoriasis vulgaris (PV) risk in a Chinese population.The genotyping of studied polymorphisms through polymerase chain reaction (PCR) and sequencing was conducted in 142 PV patients and 147 healthy controls. The genotype distribution of the polymorphisms in the control group was checked to determine whether it conformed to Hardy-Weinberg equilibrium (HWE). Read More

    Autoimmune diseases and breast cancer risk by tumor hormone-receptor status among elderly women.
    Int J Cancer 2017 Nov 16. Epub 2017 Nov 16.
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Institute of Health, Bethesda, Maryland, U.S.A.
    The female preponderance of many autoimmune diseases suggests a possible hormonal etiology. Little research exists on systemic and organ-specific autoimmune diseases and risk of breast cancer by tumor estrogen receptor (ER)- and progesterone receptor (PR)- status. Here we evaluate associations between selected systemic and organ-specific autoimmune diseases and breast cancer risk overall and by tumor ER- and PR-status. Read More

    Treatment Approaches to Moderate to Severe Psoriasis.
    Int J Mol Sci 2017 Nov 16;18(11). Epub 2017 Nov 16.
    Department of Medicine, Section of Dermatology and Venereology, University of Verona, 37129 Verona, Italy.
    Psoriasis is a common disease, which has a considerable impact on patients and the health care system. Treatment approaches to the disease may be various because some issues are not definitely addressed. Moreover, the therapeutic paradigms are continuously changing because of the recent approval of new treatments for psoriasis such as interleukin (IL)-17 inhibitors and apremilast. Read More

    C-Jun expression in lichen planus, psoriasis and cutaneous squamous cell carcinoma, an immunohistochemical study.
    J Immunoassay Immunochem 2017 Nov 16. Epub 2017 Nov 16.
    c Dermatology Departments , Shibin Elkom Teaching Hospital , Egypt.
    The AP-1 transcription factor complex is a key player in regulating inflammatory processes, cell proliferation, differentiation and cell transformation. The aim of the present study is to investigate C-Jun (one of AP-1complex) expression and its proliferative role in skin samples of lichen planus, psoriasis as common inflammatory skin diseases and squamous cell carcinoma using immunohistochemical method. The present study was carried out on skin biopsies of 15 psoriatic patients, 15 lichen planus patients, 15 SCC and 15 normal skin biopsies. Read More

    Correlation between plasmatic levels of Vitamin D and PASI score: our experience and mini-review of the literature.
    G Ital Dermatol Venereol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Internal Medicine and Medical Specialties, UOC of Dermatology and Venereology, University of Rome "Sapienza", Rome, Italy.
    Background: Psoriasis is a common, inflammatory, chronic, relapsing skin disease. The pathogenesis is multifactorial and it is involved both innate and acquired immunity. Several studies have shown the important role of vitamin D in the pathogenesis of this disorder. Read More

    Analysis of anti-TNF-induced skin lesions reveals strong Th1 activation with some distinct immunological characteristics.
    Br J Dermatol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
    Background: Psoriasiform and eczematous eruptions are the most common dermatological adverse reaction linked to anti-TNF-α therapy. Yet, a detailed characterization of their immune phenotype is lacking.

    Objectives: We sought to characterize anti-TNF-α induced inflammatory skin lesions on a histopathologic, cellular and molecular level, compared to psoriasis, eczema (atopic dermatitis), and healthy control skin. Read More

    The Efficacy of Biologic Therapy for the Management of Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review.
    Dermatol Ther (Heidelb) 2017 Dec 15;7(4):425-446. Epub 2017 Nov 15.
    Department of Dermatology, University of California San Francisco, San Francisco, USA.
    Introduction: Palmoplantar psoriasis (PP) and palmoplantar pustulosis (PPP) are diseases affecting the hands and/or feet that can cause marked physical discomfort and functional disability. The tumor necrosis factor-alpha antagonists adalimumab, etanercept, and infliximab, the interleukin (IL)-17A inhibitors ixekizumab and secukinumab, and the IL-23 or IL-12/IL-23 inhibitors guselkumab and ustekinumab have been well studied for the treatment of moderate to severe plaque psoriasis. Less is known about the efficacy and safety of these agents for the treatment of PP (hyperkeratotic and pustular forms) and PPP. Read More

    Antipsoriatic and Anti-inflammatory Studies of Berberis aristata Extract Loaded Nanovesicular Gels.
    Pharmacogn Mag 2017 Oct 8;13(Suppl 3):S587-S594. Epub 2017 Sep 8.
    Department of Pharmaceutical Sciences, Shri Rawatpurwa Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India.
    Objective: Novel nanovesicular gel of Berberis aristata extract was developed and evaluated for its anti-inflammatory and antipsoriatic activity.

    Materials And Methods: Transferosomes were prepared using soya phosphatidylcholine and edge activators (Tween 80, Span 80, and sodium deoxycholate) by a modified lipid film hydration technique using rotary evaporator and evaluated for various parameters. The quantification and standardization of extract have been carried out using its alkaloid content as berberine as biomarker. Read More

    The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function.
    Sci Rep 2017 Nov 15;7(1):15631. Epub 2017 Nov 15.
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany.
    Psoriasis is a TH17-driven inflammatory disease affecting a significant proportion of the world population. The molecular consequences of IL-17 signaling in the skin are only partially understood. Therefore, we evaluated the IL-17A effects on organotypic 3-dimensional skin models and observed that IL-17A interfered with keratinocyte differentiation. Read More

    Minimal Disease Activity as a Treatment Target in Psoriatic Arthritis: A Review of the Literature.
    J Rheumatol 2017 Nov 15. Epub 2017 Nov 15.
    From Sorbonne Universités, UPMC Univ Paris 06; Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital, Paris, France; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; Dipartimento di Medicina e Scienze della Salute, Università degli Studi del Molise, Campobasso, Italy; Hospital Universitario La Paz, Rheumatology Department, Madrid, Spain; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Rheumatology University Hospital Frankfurt and Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Goethe University Frankfurt am Main, Frankfurt, Germany. This article was drafted following a roundtable discussion funded by Novartis and attended by the authors, for which they received honoraria from Novartis. L. Gossec, Professor, MD, PhD, AP-HP, Pitié Salpêtrière Hospital; D. McGonagle, Professor, PhD, FRCPI, NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Rheumatic and Musculoskeletal Medicine; T. Korotaeva, Professor, MD, PhD, Department of Psoriatic Arthritis, V.A. Nasonova Research Institute of Rheumatology; E. Lubrano, Aggregate Professor, MD, Academic Rheumatology Unit, Department of Medicine and Health Sciences, University of Molise; E. de Miguel, Associate Professor, MD, PhD, Academic Rheumatology Unit, Hospital Universitario La Paz; M. Østergaard, Professor, MD, PhD, Copenhagen University Hospital, and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases; F. Behrens, MD, Head Clinical Research Rheumatology and Fraunhofer Institute IME. Address correspondence to Prof. L. Gossec, Hôpital Pitié-Salpétrière, Service de Rhumatologie, 47-83, Boulevard de l'Hôpital, 75013 Paris, France. E-mail: Full Release Article. For details see Reprints.
    As in other inflammatory rheumatic diseases, the objective of psoriatic arthritis (PsA) treatment is the achievement of a defined target. Recent recommendations propose aiming for remission or low disease activity; however, a consensual definition of remission is lacking. A state of minimal disease activity (MDA) has been established and is defined by low activity assessed by tender/swollen joint counts, tender entheseal points, Psoriasis Area and Severity Index or body surface area, patient pain and global activity visual analog scale, and functional evaluation by Health Assessment Questionnaire. Read More

    Anti-inflammatory activity of extra virgin olive oil polyphenols: which role in the prevention and treatment of immune-mediated inflammatory diseases?
    Endocr Metab Immune Disord Drug Targets 2017 Nov 13. Epub 2017 Nov 13.
    Istituto Superiore di Sanita, Center for Gender-specific Medicine, Viale Regina Elena 299; 00161 Rome. Italy.
    Altered inflammatory response characterizes chronic immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, and psoriasis. Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source of fat in the Mediterranean diet, is associated with a reduced risk of developing chronic degenerative disorders such cardiovascular diseases, type 2 diabetes and cancer. The beneficial effects on health of EVOO have been attributed, besides to the monounsaturated fats content, to the presence of phenolic compounds that have antioxidant, anti-inflammatory and immunomodulatory properties. Read More

    Certolizumab Pegol in the Treatment of Psoriasis and Psoriatic Arthritis: Preliminary Real-Life Data.
    Dermatol Ther (Heidelb) 2017 Dec 14;7(4):485-492. Epub 2017 Nov 14.
    Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.
    Introduction: We present the results of real-life tests conducted in adults affected by psoriatic arthritis (PsA) with mild cutaneous involvement to evaluate the efficacy of certolizumab pegol (CZP), an anti-tumor necrosis factor-alpha agent approved in Europe for the treatment of rheumatoid arthritis and PsA.

    Methods: Assessments included an evaluation of the Psoriasis Area and Severity Index (PASI) and the Disease Activity Score computed on 44 joints (DAS-44) correlated to the erythrocyte sedimentation rate (ESR) (DAS44-ESR). A total of 41 patients (16 men, 25 women; mean age 59. Read More

    Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.
    Sci Rep 2017 Nov 14;7(1):15564. Epub 2017 Nov 14.
    Department of Otolaryngology, School of Medicine, Ajou University, Suwon, Republic of Korea.
    Plasma medicine is an emerging novel therapeutic field. It has been reported that plasma can kill bacteria, promote wound healing and induce apoptosis of tumor cells. However, the effects of plasma on immune cells and immune related skin diseases have not been well studied. Read More

    Skin-Specific CD301b(+) Dermal Dendritic Cells Drive IL-17-Mediated Psoriasis-Like Immune Response in Mice.
    J Invest Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:
    Conventional dendritic cells (cDCs) are composed of heterogeneous subsets commonly arising from DC-committed progenitors. A population of CD301b-expressing DCs has recently been identified in non-lymphoid barrier tissues such as skin. However, whether CD301b(+) DCs in the skin represent ontogenetically unique subpopulation of migratory cDCs has not been fully addressed. Read More

    Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-κB pathways.
    J Dermatol Sci 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street Charlestown, Boston, MA 02129, USA. Electronic address:
    Background: Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported.

    Objective: The present study aimed to determine the protective effects and the underlying mechanisms of RvD1 on imiquimod (IMQ)-induced psoriasiform dermatitis. Read More

    A Guide to Topical Vehicle Formulations.
    J Cutan Med Surg 2017 Nov 1:1203475417743234. Epub 2017 Nov 1.
    2 Queen's University, Kingston, ON, Canada.
    Adherence to topical treatment for a variety of chronic skin conditions, such as psoriasis, acne, and atopic dermatitis, is known to be very poor. A number of factors contribute to this phenomenon, including lack of treatment efficacy and patient concerns regarding side effects, among others. At the forefront of barriers facing optimal patient adherence to topical treatment is choosing the ideal topical vehicle formulation. Read More

    Mesenchymal stem cells inhibit RANK-RANKL interactions between osteoclasts and Th17 cells via osteoprotegerin activity.
    Oncotarget 2017 Oct 28;8(48):83419-83431. Epub 2017 Sep 28.
    Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
    Th17 cells play a critical role in several autoimmune diseases, including psoriasis and psoriatic arthritis (PsA). Psoriasis is a chronic inflammatory skin disease associated with systemic inflammation and comorbidities, such as PsA. PsA develops in nearly 70% of patients with psoriasis, and osteoclasts associated bone erosion is a hallmark of the disease. Read More

    Screening of Skin Lesion-Associated Genes in Patients with Psoriasis by Meta-Integration Analysis.
    Dermatology 2017 Nov 15. Epub 2017 Nov 15.
    Department of Dermatology, West China Hospital, Sichuan University, Chengdu, PR China.
    Aim: Psoriasis is an inflammatory skin disease, and approximately one quarter of individuals with psoriasis develop painful and debilitating arthritis. As a complex and polygenetic hereditary disease, it is significant to investigate skin lesion-associated genes of psoriasis.

    Method: In the present study, a total of 3,047 differentially expressed genes between lesional and nonlesional skin of psoriasis patients were screened based on 4 data sets in GEO DataSets. Read More

    Efficacy and safety of tofacitinib for moderate-to-severe plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials.
    J Eur Acad Dermatol Venereol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
    The effects of tofacitinib in treating moderate-to-severe plaque psoriasis were unclear. We aimed to assess the effects of tofacitinib in treating moderate-to-severe plaque psoriasis. We searched PubMed, Cochrane Central Register of Controlled Trials, and EMBASE for relevant randomised controlled trials (RCTs), and conducted a systematic review and meta-analysis. Read More

    Treating Moderate-to-Severe Plaque Psoriasis With Guselkumab: A Review of Phase II and Phase III Trials.
    Ann Pharmacother 2017 Nov 1:1060028017743268. Epub 2017 Nov 1.
    1 Wake Forest School of Medicine, Winston-Salem, NC, USA.
    Objective: Guselkumab, an anti-interleukin-23 monoclonal antibody was recently approved for the treatment of patients with moderate-to-severe plaque psoriasis. This article will review the available phase II and phase III guselkumab clinical trial data.

    Data Sources: A PubMed search was conducted using the terms guselkumab, interleukin-23, psoriasis, adalimumab, and ustekinumab (January 2014 to August 2017). Read More

    DFD-01 Reduces Transepidermal Water Loss and Improves Skin Hydration and Flexibility.
    Dermatol Ther (Heidelb) 2017 Dec 13;7(4):507-514. Epub 2017 Nov 13.
    cyberDERM Clinical Studies, Broomall, PA, USA.
    Introduction: In plaque psoriasis, the benefit of topical steroids is well established. The vehicle formulation of topical steroids may also provide benefit in addition to the effects of the steroid itself. DFD-01 (betamethasone dipropionate spray, 0. Read More

    Methoxsalen-induced macular toxicity.
    Indian J Ophthalmol 2017 Nov;65(11):1243-1245
    Shri Bhagwan Mahavir Department of Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Psoralen compounds such as methoxsalen are photosensitizer agents used in conjunction with ultraviolet A (UVA) radiation exposure as photochemotherapy (Psoralens and ultraviolet-A therapy [PUVA therapy]) for certain epidermal skin disorders such as psoriasis and vitiligo. Methoxsalen has been shown to be associated with premature cataract formation by forming adducts with lens proteins following oral administration and subsequent UVA exposure. Hence, the use of UV-filtering glasses is recommended during PUVA therapy sessions. Read More

    Towards topical microRNA-directed therapy for epidermal disorders.
    J Control Release 2017 Nov 10;269:136-147. Epub 2017 Nov 10.
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, United Kingdom. Electronic address:
    There remains an unmet dermatological need for innovative topical agents that achieve better longterm outcomes with fewer side effects. Modulation of the expression and activity of microRNA (miRNAs) represents an emerging translational framework for the development of such innovative therapies because changes in the expression of one miRNA can have wide-ranging effects on diverse cellular processes associated with disease. In this short review, the roles of miRNA in epidermal development, psoriasis, cutaneous squamous cell carcinoma and re-epithelisation are highlighted. Read More

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