45,685 results match your criteria Psoriasis


Stevens-Johnsons syndrome or drug-induced lupus - a clinical dilemma: A case report and review of the literature.

Biomed Rep 2018 Jul 16;9(1):37-41. Epub 2018 May 16.

Department of Internal Medicine and Rheumatology, 'Sfanta Maria' Hospital, 011172 Bucharest, Romania.

Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]. During treatment with TNF inhibitors, many patients develop positivity for antinuclear, antihistone and anti-double stranded DNA antibodies, though only a minority of patients will develop clinical manifestations and approximately less than 1% will fulfill the classification criteria for systemic lupus erythematosus. Mucocutaneous manifestations are the most frequent manifestations of DIL following treatment with TNF inhibitors, and can be severe and occasionally difficult to differentiate from erythema multiforme/SJS. Read More

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Malignancy development risk in psoriatic arthritis patients undergoing treatment: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 May 23. Epub 2018 May 23.

Departments of Rheumatology and Clinical Immunology Center, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, #41 Damucang xidan, Beijing, China.

Background: Psoriatic arthritis (PsA) is a chronic and seronegative inflammatory arthritis occurring in patients with psoriasis. The current knowledge about the risk of malignancy associated with psoriatic arthritis (PsA) patients undergoing therapy is controversial. We focused on the relationship between malignancy and therapy and undertook a meta-analysis to address this issue. Read More

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Drugs on the Horizon for Chronic Pruritus.

Dermatol Clin 2018 Jul 26;36(3):335-344. Epub 2018 Apr 26.

Kaplan-Amonette Department of Dermatology, University of Tennessee Health Science Center, 930 Madison Avenue, Suite 840, Memphis, TN 38163, USA. Electronic address:

Chronic pruritus is a common condition that has a detrimental impact on quality of life. As the molecular pathogenesis of itch is elucidated, novel therapies that disrupt itch pathways are being investigated. Emerging treatments include drugs targeting the neural system, drugs targeting the immune system, antihistamines, bile acid transport inhibitors, and topical drugs that work through a variety of mechanisms such as phosphodiesterase-4 inhibition or targeting of nerve ion channels. Read More

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High Sensitivity C-Reactive Protein Level and Psoriasis Severity in Thai Patients.

J Med Assoc Thai 2016 Sep;99(9):1039-45

Background: Psoriasis vulgaris severity have been widely assessed by psoriasis area severity index (PASI) score. However, it may not be not the best measure because of the high variability and inability to tell the other aspect of the disease including co-morbidity and cardiovascular risk.

Objective: To determine the correlation between high sensitivity C-reactive protein (hs-CRP) level and psoriasis severity and to determine co-morbidities of psoriasis patients. Read More

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September 2016

CADM1 is a diagnostic marker in early-stage mycosis fungoides: Multicenter study of 58 cases.

J Am Acad Dermatol 2018 Jun 18. Epub 2018 Jun 18.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences. Electronic address:

Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 (CADM1), initially identified as a tumor suppressor gene in human non-small-cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma (ATLL). Read More

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June 2018
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Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies.

J Am Acad Dermatol 2018 Jun 18. Epub 2018 Jun 18.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen. Electronic address:

Background: Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported.

Objectives: To assess the prevalence and incidence of PsA in patients with psoriasis.

Methods: Two authors independently searched three databases for studies reporting on the prevalence or incidence of PsA in patients with psoriasis. Read More

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Mild electrical stimulation with heat shock reduces the inflammatory symptoms in imiquimod-induced psoriasis mouse model.

Exp Dermatol 2018 Jun 21. Epub 2018 Jun 21.

Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.

Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Read More

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Human αβ and γδ T Cells in Skin Immunity and Disease.

Front Immunol 2018 6;9:1304. Epub 2018 Jun 6.

Department of Biological Sciences, California State University of San Marcos, San Marcos, CA, United States.

γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication, or disrupt proper wound healing. Much of the published work on human skin T cells attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked participant. Read More

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Secukinumab in pregnancy: outcomes in psoriasis, psoriatic arthritis and ankylosing spondylitis from the global safety database.

Br J Dermatol 2018 Jun 21. Epub 2018 Jun 21.

Novartis Pharmaceuticals Corporation, East Hanover, USA.

Psoriasis, psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are chronic inflammatory conditions. Effective long term treatment may be necessary in women of childbearing age, but data concerning current treatments and pregnancy remain incomplete. Due to immunological changes, psoriasis and, to a lesser extent, PsA generally improve during pregnancy ; however, many pregnant patients still require treatment. Read More

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Hydroxyurea and Acitretin as a novel combination therapy in severe plaque psoriasis.

Br J Dermatol 2018 Jun 21. Epub 2018 Jun 21.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Combinations of systemic modalities are required sometimes for disease control in refractory cases of psoriasis. Usually, systemic agents with non-overlapping adverse effect profiles are combined together for variable time periods to achieve remission. Combination therapy is expected to improve the therapeutic outcome and minimize cumulative toxicity resulting from prolonged use of single systemic agents. Read More

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Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.

Br J Clin Pharmacol 2018 Jun 21. Epub 2018 Jun 21.

Merck & Co., Inc., Kenilworth, NJ, USA.

Aims: Tildrakizumab, an interleukin (IL)-23 inhibitor, is indicated for the treatment of moderate to severe chronic plaque psoriasis. Although tildrakizumab is not metabolized by, and does not alter, cytochrome P450 (CYP) expression in vitro, clinically-significant pharmacokinetic effects through changes in systemic inflammation, which alters CYP metabolism, have been well documented. At the time of study conduct, the effect of modulation of inflammation/cytokines, including IL-23 inhibition with tildrakizumab, on CYP metabolism, and therefore the potential for disease-drug interactions, in psoriasis patients was unknown. Read More

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June 2018
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Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review.

JAMA Dermatol 2018 Jun 20. Epub 2018 Jun 20.

Keck School of Medicine, University of Southern California, Los Angeles.

Importance: Psoriasis is a chronic, inflammatory skin disease and has significant associated morbidity and effect on quality of life. It is important to determine whether dietary interventions help reduce disease severity in patients with psoriatic diseases.

Objective: To make evidence-based dietary recommendations for adults with psoriasis and/or psoriatic arthritis from the Medical Board of the National Psoriasis Foundation. Read More

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Distinguishing Mild, Moderate, and Severe Hidradenitis Suppurativa.

JAMA Dermatol 2018 Jun 20. Epub 2018 Jun 20.

Psoriasis Research and Treatment Center, Clinic of Dermatology, Venereology, and Allergology and Institute of Medical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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Does Gastric Surgery (Such as Bariatric Surgery) Impact the Risk of Intestinal Inflammation?

Inflamm Intest Dis 2016 Oct 15;1(3):129-134. Epub 2016 Sep 15.

Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.

Background: The prevalence of morbid obesity and inflammatory bowel disease (IBD) is on the rise in association with a Western lifestyle. Both conditions are characterized by chronic inflammation. Bariatric surgery (BS) is a recommended and widely used approach to address severe obesity and its related comorbidities. Read More

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October 2016
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WhatsApp: A Real-Time Tool to Reduce the Knowledge Gap and Share the Best Clinical Practices in Psoriasis.

Telemed J E Health 2018 Jun 20. Epub 2018 Jun 20.

2 Department of Dermatology, Hospital Eva Perón , Gral San Martín, Buenos Aires, Argentina .

Background: Psoriasis is a chronic inflammatory disease that affects around 100 million people worldwide. The burden of disease is high, but more recent therapies show promising results. Clinicians need, however, more training in the use of such therapies. Read More

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June 2018
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Density of mast cells and intensity of pruritus in psoriasis vulgaris: a cross sectional study.

An Bras Dermatol 2018 Jun;93(3):368-372

Service of Dermatology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Background: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-to-control symptom. The mediators involved in psoriatic pruritus have not been fully established.

Objective: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. Read More

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Dermoscopy in tinea manuum.

An Bras Dermatol 2018 Jun;93(3):447-448

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

Tinea manuum is a dermatophytosis which is often mistaken for other keratodermas, especially palmar psoriasis and chronic hand eczema. We report the use of dermoscopy as a diagnostic aid in a case of tinea manuum. The dermoscopic clue turned out to be the presence of whitish scaling located mainly in the furrows. Read More

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Tazarotene gel with narrow-band UVB phototherapy: a synergistic combination in psoriasis.

An Bras Dermatol 2018 Jun;93(3):385-390

Department of Dermatology, Venereology and Leprology, Pandit B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

Background: Narrow-band UVB (NB-UVB) has been shown to be one of the most effective treatment modalities for psoriasis. Tazarotene, a known effective anti-psoriatic modality, when combined with NB-UVB may enhance the therapeutic success.

Objective: To study clinical efficacy and safety of combination of NB-UVB with topical tazarotene 0. Read More

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Erythrodermic psoriasis and human immunodeficiency virus: association and therapeutic challenges.

An Bras Dermatol 2018 Jun;93(3):438-440

School of Medicine, Faculty of Medicine, University of Chile, Santiago, Chile.

Erythrodermic psoriasis is a rare but severe type of psoriasis that may be triggered by human immunodeficiency virus infection. We describe the case of a 65-year-old male patient with chronic psoriasis who presents an exacerbation of his condition over a period of two weeks. Because of the severity of his case and subsequent need for systemic therapy, human immunodeficiency virus enzyme immunoassay was performed and tested positive. Read More

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Ocular manifestations of psoriasis.

Arq Bras Oftalmol 2018 Jun;81(3):219-225

Dermatology Department, Universidade do Estado do Pará, Belém, PA, Brazil.

Purpose: We aimed to report the ocular manifestations observed in patients with psoriasis.

Methods: Patients were included and referred to our ophthalmology clinic from dermatology clinics of Universidade do Estado do Pará between October 2013 and August 2014. Clinical interviews were conducted to identify relevant epidemiological data, clinical features, and treatment details, and data were recorded using the same protocol. Read More

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June 2018
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Association between psoriasis and vitamin D: Duration of disease correlates with decreased vitamin D serum levels: An observational case-control study.

Medicine (Baltimore) 2018 Jun;97(25):e11185

Section of Dermatology, Department of Biomedical Science and Human Oncology.

Recent literature has focused on the association of psoriasis with lower than normal or highly deficient vitamin D blood levels.To investigate the controversial association between psoriasis and vitamin D levels.From 2012 to 2014, 561 subjects were assessed, of which 170 had psoriasis, 51 had an autoimmune bullous, and 340 were healthy patients. Read More

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Keratinocytes derived from late-onset psoriasis skin do not impair Langerhans cell migration.

Br J Dermatol 2018 Jun 19. Epub 2018 Jun 19.

The University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, M6 8HD.

Chronic plaque psoriasis (CPP) is associated with over-expression of interleukin (IL)-17 and systemic antibody therapies targeting this cytokine are highly efficacious . Psoriasis presents as either early- or late-onset disease (before or after 40 years of age, respectively). Langerhans cells (LC) are the dendritic cells of the epidermis that regulate cutaneous immune responses . Read More

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June 2018
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The self-assessed psychological comorbidities of prurigo in European patients: A multi-centre study in 13 countries.

J Eur Acad Dermatol Venereol 2018 Jun 19. Epub 2018 Jun 19.

Department of Dermatology, University Hospital, Brest, France.

Background: Prurigo is defined by the presence of chronic pruritus and multiple localized or generalized pruriginous lesions.

Objective: The aim of this study was to assess the psychological burden of prurigo in patients of European countries.

Methods: In this multicentre European study, 3635 general dermatology outpatients and 1359 controls were included. Read More

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June 2018
2 Reads

Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches.

Int J Dermatol 2018 Jun 19. Epub 2018 Jun 19.

Drug Discovery Lab, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gujarat, India.

Skin is the most visible and vulnerable organ of the integumentary system. Psoriasis is a chronic inflammatory skin disorder with an equal prevalence rate in males and females globally. Psoriasis is seen today beyond a cosmetic turmoil as it significantly impacts the socioeconomic life of the patients. Read More

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Whodunit? The Contribution of Interleukin (IL)-17/IL-22-Producing γδ T Cells, αβ T Cells, and Innate Lymphoid Cells to the Pathogenesis of Spondyloarthritis.

Front Immunol 2018 25;9:885. Epub 2018 Apr 25.

Institute of Immunology, Hannover Medical School, Hannover, Germany.

γδ T cells, αβ T cells, and innate lymphoid cells (ILCs) are capable of producing interleukin (IL)-17A, IL-17F, and IL-22. Among these three families of lymphocytes, it is emerging that γδ T cells are, at least in rodents, the main source of these key pro-inflammatory cytokines. γδ T cells were implicated in multiple inflammatory and autoimmune diseases, including psoriasis, experimental autoimmune encephalomyelitis and uveitis, colitis, and rheumatoid arthritis. Read More

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Current treatment options for psoriatic arthritis: spotlight on abatacept.

Ther Clin Risk Manag 2018 6;14:1053-1059. Epub 2018 Jun 6.

Rheumatology Department of Lucania, Rheumatology Institute of Lucania (IReL), Potenza Italy.

Psoriatic arthritis (PsA) is a chronic inflammatory disease of joints, tendon sheaths, and entheses affecting patients with established skin psoriasis, or, less frequently, patients without a personal history of psoriasis with a positive familial history. Many treatment options are now available to deal with the different aspects of the disease, including traditional and biological disease-modifying antirheumatic drugs and the recently released targeted synthetic disease-modifying antirheumatic drugs. However, ~40% of patients still fail to achieve a meaningful clinical response to first-line biologic therapy advocating the development of novel medications. Read More

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Increased Risks of Autoimmune Rheumatic Diseases in Patients with Psoriasis: A Nationwide Population-based Study.

J Am Acad Dermatol 2018 Jun 16. Epub 2018 Jun 16.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea. Electronic address:

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June 2018
2 Reads

Topical application of anthranilate derivatives ameliorates psoriatic inflammation in a mouse model by inhibiting keratinocyte-derived chemokine expression and neutrophil infiltration.

FASEB J 2018 Jun 19:fj201800354. Epub 2018 Jun 19.

Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan.

Psoriasis is an inflammatory autoimmune skin disorder possessing a complex etiology related to genetic and environmental triggers. Keratinocytes show a potential role for the origin of psoriasis. In this study, we estimated the efficiency of 2 anthranilate derivatives-(E)-4-( N-{2-[1-(hydroxyimino)ethyl]phenyl}sulfamoyl)phenyl pivalate (HFP031) and butyl 2-[2-(2-fluorophenyl)acetamido]benzoate (HFP034)-on psoriasis amelioration in a mouse model. Read More

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Phase 3 randomised study of the proposed biosimilar adalimumab GP2017 in psoriasis - impact of multiple switches.

Br J Dermatol 2018 Jun 19. Epub 2018 Jun 19.

Central Dermatology, St Louis, MO, U.S.A.

Background: The impact of multiple switches between GP2017 and reference adalimumab (ref-ADMB) was assessed following the demonstration of equivalent efficacy and similar safety and immunogenicity, in adult patients with active, clinically stable, moderate-to-severe plaque psoriasis.

Methods: This 51-week double-blinded, phase 3 study randomly assigned patients to GP2017 (N=231) or ref-ADMB (N=234) 80 mg subcutaneously at Week 0, then 40 mg biweekly from Week 1. At Week 17, patients were re-randomised to switch (n=126) or continue (n=253) treatment. Read More

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June 2018
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Inhibitory effects of TGP on KGF‑induced hyperproliferation of HaCaT cells via suppression of the p38 MAPK/NF‑κB p65 pathway.

Mol Med Rep 2018 Jun 15. Epub 2018 Jun 15.

College of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Taiyuan, Shanxi 030619, P.R. China.

Psoriasis is a chronic inflammatory skin disease, primarily caused by overgrowth and abnormal differentiation of epidermal keratinocytes. Studies have suggested that keratinocyte growth factor (KGF) may be involved in the regulation of differentiation and development of keratinocytes. Total glucosides of peony (TGP) have been widely used for the treatment of psoriasis. Read More

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June 2018
3 Reads

Efficacy assessment of UVA1 and narrowband UVB for treatment of scalp psoriasis.

Lasers Med Sci 2018 Jun 18. Epub 2018 Jun 18.

Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.

To compare the efficacy and safety of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of scalp psoriasis. Patients with scalp psoriasis were randomly assigned to either UVA1 or NB-UVB therapy. Both treatments were performed three times weekly for 6 weeks. Read More

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June 2018
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A deadly prescription: combination of methotrexate and trimethoprim-sulfamethoxazole.

J Community Hosp Intern Med Perspect 2018 12;8(3):149-151. Epub 2018 Jun 12.

Pulmonary and Critical Care, Abington Hospital-Jefferson Health, Abington, PA, USA.

Methotrexate (MTX) is a chemotherapeutic synthetic(s) phase cell cycle inhibitor, and its role has evolved as an immunological agent in autoimmune diseases like rheumatoid arthritis, psoriasis, and systemic lupus erythematosus, etc. Trimethoprim-sulfamethoxazole (TS) is one of the most widely prescribed antibiotics commonly used for urinary tract infections, exacerbations of chronic bronchitis, traveler's diarrhea, and pneumocystis pneumonia. Both MTX and TS can have significantly overlapping side effects involving dermatologic, renal, and hematological systems, and the combination of these can be deadly. Read More

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Psoriasis localized to the glans penis in a 37-year-old man.

CMAJ 2018 Jun;190(24):E747

Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

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Integrative methylome and transcriptome analysis to dissect key biological pathways for psoriasis in Chinese Han population.

J Dermatol Sci 2018 Jun 9. Epub 2018 Jun 9.

Institute of Dermatology and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, 230032, China. Electronic address:

Background: Recent studies have revealed that DNA methylation (DNAm) could modulate gene expression in psoriasis (Ps). However, the relationship between whole-genome DNAm and gene expression in Ps has not been studied yet.

Objectives: To better characterize the relationship between DNAm and gene expression, and to identify biological pathways triggered by changes in methylation involved in the pathogenesis of Ps. Read More

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Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.

J Dermatol Sci 2018 May 29. Epub 2018 May 29.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. Electronic address:

Background: Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-α inhibitors. TNF-α is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. Read More

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May 2018
3 Reads

Codeine-induced acute generalized exanthematous pustulosis without IL36RN mutations.

Pharmacogenomics 2018 Jun 19. Epub 2018 Jun 19.

Pharmacology Department, Faculty of Medicine, University of Monastir, Tunisia.

Recent studies have suggested an association between mutations in the IL-36RN gene and the onset of pustular generalized. In the literature, only one case of acute generalized exanthematous pustulosis (AGEP) induced by codeine in a patient with IL36RN mutation has been reported. Herein, we reported an unusual case of AGEP caused by codeine in a patient with a history of psoriasis and confirmed by an oral provocation test. Read More

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Rituximab-Treated Pemphigus Foliaceus in a Schizophrenic Patient: A Challenging Exercise in Diagnosis, Management, and Follow-Up.

Skinmed 2018 1;16(2):129-131. Epub 2018 Apr 1.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA;

Dermatology was consulted in the care of a 58-year-old man with a history of paranoid schizophrenia, neuroleptic malignant syndrome, a positive purified protein derivative test, and a lack of bathing for approximately 4 years who had been admitted to the hospital because of thick, crusted lesions over an increasing portion of his body. Admitted involuntarily, he was disinterested in the history, physical examination, and diagnostic testing. Comorbid schizophrenia presented a unique challenge because he was unable to participate in his care effectively. Read More

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Potential Immunological Links Between Psoriasis and Cardiovascular Disease.

Front Immunol 2018 1;9:1234. Epub 2018 Jun 1.

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

Preclinical and clinical research provide strong evidence that chronic, systemic inflammation plays a key role in development and progression of atherosclerosis. Indeed, chronic inflammatory diseases, such as psoriasis, are associated with accelerated atherosclerosis and increased risk of cardiovascular events. Contemporary research has demonstrated plausible mechanistic links between immune cell dysfunction and cardiometabolic disease in psoriasis. Read More

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Is psoriasis a bowel disease? Successful treatment with bile acids and bioflavonoids suggests it is.

Authors:
P Haines Ely

Clin Dermatol 2018 May - Jun;36(3):376-389. Epub 2018 Mar 28.

VA North California Health Care System, Mather, CA; University of California Davis School of Medicine, Sacramento, CA; Department of Dermatology, Sacramento VA Medical Center, Mather, CA. Electronic address:

The gut is the largest lymphoid organ in the body. The human microbiome is composed of trillions of bacteria. The DNA of these bacteria dwarfs the human genome. Read More

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March 2018
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The use of balneotherapy in dermatology.

Clin Dermatol 2018 May - Jun;36(3):363-368. Epub 2018 Mar 13.

Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, NY.

Balneotherapy is the treatment of disease by bathing in thermal spring water. This therapy has been used for centuries and remains a popular form of treatment for dermatologic and rheumatologic diseases today. Although the favorable climates of balneotherapy thermal centers have known beneficial effects on psoriasis and atopic dermatitis, the thermal spring waters themselves can also potentially decrease skin inflammation. Read More

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Russian traditional medicine in dermatology.

Clin Dermatol 2018 May - Jun;36(3):325-337. Epub 2018 Mar 13.

Rakhmanov Department of Dermatology and Venereal Diseases at the First Moscow State Sechenov Medical University of the Russian Federation, Moscow, Russia; Institute of Medical and Social Technologies, Postgraduate Medical School, Department of Dermatology, Venereology and Cosmetology, Moscow State University of Food Production, Moscow, Russia; Department of Dermatology, Bedford Hospital, Bedford, UK. Electronic address:

The use of herbal remedies for various medical issues is becoming increasingly commonplace in all fields of medicine, and dermatology is no exception. This review focuses on traditional dermatologic herbal remedies, commonly used in Russia, as the rich array of 11 different plant zones has resulted in a great variety of medicinal plants. Herbal remedies warrant deeper investigation and research, especially due to their active substance content, which may interfere with or reinforce the effect of modern medications, something that medical professionals should be aware of when prescribing treatments. Read More

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Physician's Global Assessment in Psoriatic Arthritis: A Multicenter GRAPPA Study.

J Rheumatol 2018 Jun 15. Epub 2018 Jun 15.

From the Department of Medical Sciences, Policlinico of the University of Cagliari; Rheumatology Unit, and Department of Public Health, University of Cagliari, Cagliari; Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Matera; Rheumatology Research Unit, Department of Clinical and Experimental Medicine, University "Federico II," Naples; Department of Rheumatology, ASST Gaetano Pini-Centro Traumatologico Ortopedico (CTO), Milan; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Modena and Reggio Emilia; Dipartimento di Medicina e Scienze della Salute, Università degli Studi del Molise, Campobasso, Italy; University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada; Academic Medical Center/University of Amsterdam; Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Rehabilitation Teaching and Research Unit, Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand; Medizinische Klinik III mit Poliklinik, Friedrich-Alexander- Universität Erlangen-Nuernberg, Erlangen, Germany; Sector of Dermatology, HUCFF School of Medicine, Federal University of Rio de Janeiro and Sector of Dermatology, HUPE School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Spondyloarthritis Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland; Swedish Medical Centre and University of Washington School of Medicine, Seattle, Washington, USA; Department of Rheumatology, Semmelweis University, Budapest, Hungary; Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK. Funded by Regione Autonoma della Sardegna - L.R. n. 7/2007 annualità 2012, CRP-60098, linea A2, "Consorzio internazionale PEAC: meccanismi patogenetici nelle Spondiloartriti." A. Cauli, MD, PhD, Department of Medical Science, Policlinico di Monserrato, University of Cagliari; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, and Senior Scientist, Krembil Research Institute, and Director, Psoriatic Arthritis Program University Health Network; A. Mathieu, MD, Professor of Rheumatology and Head of Rheumatology Unit, University of Cagliari; G. Porru, MD, Department of Medical Science, Policlinico di Monserrato, University of Cagliari; P.P. Tak, MD, PhD, Professor of Rheumatology, Academic Medical Center/University of Amsterdam; C. Sardu, MD, Department of Public Health, University of Cagliari; R. Scarpa, MD, Professor of Rheumatology, Rheumatology Research Unit, Department of Clinical and Experimental Medicine, University "Federico II"; A. Marchesoni, MD, Department of Rheumatology, ASST Gaetano Pini-CTO; W.J. Taylor, PhD, MBChB, FRACP, FAFRM, Rehabilitation Teaching and Research Unit, and Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago; C. Salvarani, MD, Professor of Rheumatology, Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia; J. Kalden, MD, Medizinische Klinik III mit Poliklinik, Friedrich-Alexander-Universität Erlangen- Nuernberg; E. Lubrano, MD, PhD, Associate Professor of Rheumatology, Dipartimento di Medicina e Scienze della Salute, Università degli Studi del Molise; S. Carneiro, MD, PhD, Dermatologist and Rheumatologist, HUCFF Federal University of Rio de Janeiro, and Associate Professor of Dermatology, School of Medical Sciences, State University of Rio de Janeiro; M. Piga, MD, Department of Medical Science, Policlinico di Monserrato, University of Cagliari; A. Floris, MD, Rheumatology Unit, University of Cagliari; F. Desiati, MD, Department of Rheumatology, ASST Gaetano Pini-CTO; J.A. Flynn, MD, MBA, Med, Professor of Medicine, Director Spondyloarthritis Program, Johns Hopkins University, School of Medicine; S. D'Angelo, MD, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera Italy, and PhD Scholarship in Health Sciences, Department of Health Sciences, University of Molise; A.W. van Kuijk, MD, PhD, Amsterdam Rheumatology and Immunology Center Reade; M.G. Catanoso, MD, Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia; F. Caso, MD, PhD, Assistant Professor, Rheumatology Research Unit, Department of Clinical and Experimental Medicine, University "Federico II"; P. Contu, MD, Department of Public Health, University of Cagliari; I. Ujfalussy, MD, Department of Rheumatology Semmelweis University; P.S. Helliwell, MD, PhD, Leeds Institute of Molecular Medicine, University of Leeds; P.J. Mease, MD, Swedish Medical Center Rheumatology Research Division; Clinical Professor, University of Washington School of Medicine. Ignazio Olivieri, MD, died July 28, 2017; he was Director of the Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera. Address correspondence to Prof. A. Cauli, Dipartimento di Scienze Mediche, Università di Cagliari, ss 554, Monserrato 09042, Italy. E-mail: Accepted for publication February 28, 2018.

Objective: Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. This study assesses the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA).

Methods: Sixteen centers from 8 countries enrolled 319 consecutive patients with PsA. Read More

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Reply to comment on "Drug survival of apremilast for psoriasis in a real-world setting".

J Am Acad Dermatol 2018 Jun 12. Epub 2018 Jun 12.

Kaiser Permanente Los Angeles Medical Center, Department of Dermatology, Los Angeles, CA. Electronic address:

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Elderly psoriatic patients under biological therapies: an Italian experience.

J Eur Acad Dermatol Venereol 2018 Jun 15. Epub 2018 Jun 15.

Department of Surgery and Translational Medicine, Dermatology Unit, University of Florence.

Background: The number elderly patients with psoriasis is steadily increasing in the Western world, nevertheless they are frequently excluded from biologic clinical trials and described as a high-risk group for adverse events. Thus, there is lack of information concerning safety and effectiveness of available treatments for psoriasis in the elderly, particularly about new biologic systemic drugs.

Objective: Our aim is to describe our experience with all biological therapies currently used in the elderly (> 65 years) psoriatic patients. Read More

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Topical silver and gold nanoparticles complexed with Cornus Mas suppress inflammation in human plaques psoriasis by inhibiting NF-κB activity.

Exp Dermatol 2018 Jun 15. Epub 2018 Jun 15.

Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

New biomaterials based on nanoparticles (NPs) carrying polyphenols-rich extracts (Cornus mas) recently showed promising anti-inflammatory activity in psoriasis. We aimed to understand how topically delivered silver and gold nanoparticles complexed with Cornus mas (Ag-NPs-CM, Au-NPs-CM) modulate inflammation in psoriasis at cellular and molecular level. The impact on psoriatic inflammation was assessed in vitro on pro-inflammatory macrophages, by clinical score, high-frequency ultrasonography and immunohistology of psoriasis plaques treated with Ag-NPs-CM, Au-NPs-CM or control. Read More

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Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?

J Histochem Cytochem 2018 Jun 1:22155418782693. Epub 2018 Jun 1.

Department of Dermatology, Graduate School of Medicine, Osaka City University, Osaka, Japan.

Psoriasis is a complex chronic inflammatory skin disease characterized by epidermal thickening on the basis of increased keratinocyte proliferation and insufficient apoptosis. Laminins are important components of the basement membrane (BM) and impact on epidermal keratinocyte growth/apoptosis. Although several laminins are involved in the pathogenesis of psoriasis, it is still controversial about the expression patterns of laminin isoforms and which laminins are important in the development of psoriasis. Read More

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Guselkumab, an anti-interleukin-23 monoclonal antibody, for the treatment of moderate to severe plaque-type psoriasis in Japanese patients: Efficacy and safety results from a phase 3, randomized, double-blind, placebo-controlled study.

J Dermatol 2018 Jun 15. Epub 2018 Jun 15.

The Jikei University School of Medicine, Tokyo, Japan.

Previous global studies of guselkumab have demonstrated clinical benefits in patients with psoriasis. The aim of this 52-week, phase 3 study was to evaluate efficacy and safety of guselkumab in Japanese patients with moderate to severe plaque-type psoriasis. Patients randomly received guselkumab 50 mg or 100 mg at weeks 0, 4 and every 8 weeks, or placebo with cross-over to guselkumab 50 mg or 100 mg at week 16. Read More

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June 2018
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Metabolic syndrome and risk of incident psoriasis: prospective data from the HUNT Study, Norway.

Br J Dermatol 2018 Jun 14. Epub 2018 Jun 14.

Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Norway.

Background: Metabolic syndrome has been associated with psoriasis in cross-sectional studies, but data from prospective studies are sparse.

Objectives: To prospectively examine whether metabolic syndrome and its components are associated with risk of incident psoriasis in a large population-based study using objective measurements of cardiovascular disease risk factors.

Methods: We used data from two consecutive surveys of the HUNT Study, Norway (HUNT2, 1995-1997, and HUNT3, 2006-08). Read More

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June 2018
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Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis.

Dermatoendocrinol 2018 22;10(1):e1442159. Epub 2018 Feb 22.

International Centre for Skin Diseases DermAllegra, Am Markgrafenpark 6, Pommelsbrunn-Hohenstadt, Germany.

The pathogenetic role of vitamin D as well as its clinical correlation in inflammatory skin diseases is still uncertain. This study aimed to compare serum levels of 25(OH) vitamin D (calcidiol) in outpatients suffering from different skin diseases using the same laboratory method in one study. In routine serum samples of 1,532 patients from the previous 12 months we identified retrospectively 180 (mean age 49. Read More

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February 2018
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Cutaneous toxicity of oral low-dose methotrexate.

Proc (Bayl Univ Med Cent) 2018 Jul 22;31(3):364-366. Epub 2018 May 22.

Division of Rheumatology, Department of Medicine, University of Florida, Jacksonville, Florida.

Chemotherapy-induced acral erythema has been a known side effect of intravenous dosing but has not been reported with oral therapy. Herein we describe two patients receiving treatment with low-dose oral methotrexate who presented with acral erythema. Clinicians and rheumatologists should be aware of this potentially serious side effect of oral chemotherapy in various patient populations. Read More

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