Exp Dermatol 2021 Jun 1;30(6):853-858. Epub 2021 Feb 1.
Department of Dermatology and Cutaneous Biology, PXE International Center of Excellence in Research and Clinical Care, Jefferson Institute of Molecular Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic calcification disorders, affects the skin, eyes and the cardiovascular system due to inactivating mutations in the ABCC6 gene. There is no effective treatment for the systemic manifestations of PXE. In this study, the efficacy of INS-3001, an analogue of phytic acid, was tested for inhibition of ectopic calcification in an Abcc6 mouse model of PXE. Read More