4,588 results match your criteria Pseudotumor Cerebri


Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension-From Physiopathology to Treatment.

Authors:
Sorin Tuță

Life (Basel) 2022 Jun 8;12(6). Epub 2022 Jun 8.

Department of Neurology, "Carol Davila" University of Medicine and Pharmacy, 050471 Bucharest, Romania.

In this review, we provide an update on the pathogenesis, diagnosis, and management of adults with idiopathic intracranial hypertension (IIH) and implications of the cerebral venous system, highlighting the progress made during the past decade with regard to mechanisms of the venous outflow pathway and its connection with the cerebral glymphatic and lymphatic network in genesis of IIH. Early diagnosis and treatment are crucial for favorable visual outcomes and to avoid vision loss, but there is also a risk of overdiagnosis and misdiagnosis in many patients with IIH. We also present details about treatment of intracranial hypertension, which is possible in most cases with a combination of weight loss and drug treatments, but also in selected cases with surgical interventions such as optic nerve sheath fenestration, cerebral spinal fluid (CSF) diversion, or dural venous sinus stenting for some patients with cerebral venous sinus stenosis, after careful analysis of mechanisms of intracranial hypertension, patient clinical profile, and method risks. Read More

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Coexistence of Idiopathic Intracranial Hypertension with Unilateral Duane Retraction Syndrome Type 1 in an Adult Female.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):292-296. Epub 2022 Apr 22.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Idiopathic intracranial hypertension (IIH) is a poorly understood condition, and its presentation can coexist with other diseases. Simultaneous IIH and Duane retraction syndrome (DRS) type 1 have never been reported to coexist in an adult patient. Herein, we report a 32-year-old obese female with a history of chronic renal failure who had a renal transplant rejection 6 years prior to presentation and was treated with oral steroids and immunosuppressive medications. Read More

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Optic Disc Edema and Elevated Intracranial Pressure (ICP): A Comprehensive Review of Papilledema.

Cureus 2022 May 11;14(5):e24915. Epub 2022 May 11.

Neurosurgery, Riverside University Health System Medical Center, Moreno Valley, USA.

Papilledema is a swelling of the optic disc secondary to elevated intracranial pressure (ICP). We analyzed 79 peer-review journal articles and provided a concise summary of the etiology, epidemiology, pathophysiology, clinical presentation, evaluation, natural history, differential diagnosis, treatment, and prognosis of papilledema. Only studies written in English with the full text available were included. Read More

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Life-threatening idiopathic intracranial hypertension: the role of venous sinus stenting.

Childs Nerv Syst 2022 Jun 10. Epub 2022 Jun 10.

Neurosurgery Department, Hospital Regional Universitario de Málaga, Málaga, Spain.

Background: Idiopathic intracranial hypertension (IIH) is a clinical syndrome characterised by raised intracranial pressure with no discernible aetiology. It is relatively rare in children and its demographic features may differ from those of adults. The relationship between IIH and venous sinus stenosis (VSS) is well known. Read More

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Cerebral angiography as a tool for diagnosis and management of idiopathic intracranial hypertension syndrome.

Clin Imaging 2022 Aug 2;88:53-58. Epub 2022 May 2.

Neurosurgery Section, Universidad del Valle, Cali, Colombia; Neurosurgery Section, Hospital Universitario del Valle, Cali, Colombia.

Purpose: Idiopathic intracranial hypertension syndrome (IIH) is a pathology characterized by headache, visual disturbances, papilledema, increased cerebrospinal fluid pressure with normal cytochemistry that is not attributable to cerebral structural alterations. This study aimed to describe the usefulness of cerebral angiography in the diagnostic approach and management of patients with clinical suspicion of IIH at a fourth level hospital in Cali, Colombia.

Methods: This was a retrospective study. Read More

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Idiopathic intracranial hypertension: Evaluation of births and fertility through the Hospital Episode Statistics dataset.

BJOG 2022 May 27. Epub 2022 May 27.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Objective: Idiopathic intracranial hypertension (IIH) predominantly affects women of reproductive age with obesity, and these women have a distinct profile of hyperandrogenism and insulin resistance. Polycystic ovary syndrome (PCOS) has an established adverse fertility phenotype that typically affects obese women. As IIH may impact reproductive health, we sought to evaluate fertility, gestational complications and pregnancy outcome in IIH. Read More

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Clinical and Radiological Profile of 122 Cases of Idiopathic Intracranial Hypertension in a Tertiary Care Centre of India: An Observational Study.

Neurol India 2022 Mar-Apr;70(2):704-709

Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.

Background: Idiopathic intracranial hypertension (IIH) is well-described entity in literature. However, large studies on clinical and radiological profile are still very few from the Indian subcontinent.

Aims: To analyze the clinical and radiological profile of IIH and correlation of various clinical and radiological parameters with papilledema and CSF opening pressure. Read More

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Idiopathic intracranial hypertension in atypical demographics.

J Neurol Sci 2022 Jun 29;437:120271. Epub 2022 Apr 29.

Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Idiopathic intracranial hypertension (IIH) is a condition that most often occurs in women of reproductive age with elevated body mass index (BMI) (typical patients). Individuals outside of this demographic group (atypical patients) may have a different pathophysiology underlying raised intracranial pressure (ICP) leading to unique clinical presentations and prognosis.

Methods: Retrospective chart review of patients with IIH in typical and atypical demographic groups: men, those diagnosed at age 40 or older and those with BMI <26. Read More

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[Obesity, COVID-19 and idiopathic intracranial hypertension in pediatric population].

Andes Pediatr 2021 12 30;92(6):971-972. Epub 2022 Mar 30.

Unidad de Paciente Crítico Pediátrico, Hospital Clínico Dra. Eloísa Díaz I., Santiago, Chile.

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December 2021

Lumboperitoneal shunting in pediatric patients and the role of imaging in its evaluation.

Radiologia (Engl Ed) 2022 Mar-Apr;64(2):136-144

Departamento de Neurocirugía, Neurocirugía Pediátrica, Hospital Materno-Infantil del H.R.U. de Málaga, Málaga, Spain.

Lumboperitoneal shunting makes it possible to regulate the flow of cerebrospinal fluid by establishing a connection between the thecal sac and the peritoneal cavity. The main indication for lumboperitoneal shunting in children is idiopathic intracranial hypertension, but the technique is also useful in the treatment of postinfectious, posthemorrhagic, and normotensive hydrocephalus, as well as in the treatment of postsurgical pseudomeningocele or leakage of cerebrospinal fluid. This article reviews nine cases treated at our centre to show the normal imaging findings for lumboperitoneal shunts in children and to provide a succinct review of the possible neurological and abdominal complications associated with this treatment. Read More

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The diagnostic dilemma of idiopathic intracranial hypertension in a child with acute lymphoblastic leukemia: COVID-19 or cytosine arabinoside?

BMC Neurol 2022 May 2;22(1):163. Epub 2022 May 2.

Department of Hematology at Fattouma Bourguiba Hospital, Monastir, Tunisia.

Background: Idiopathic intracranial hypertension is a rare neurological condition among children. Its manifestations vary from mild headaches to loss of vision. Although rare, COVID-19 infection and high dose cytosine arabinoside have been reported as risk factors for this neurological disorder. Read More

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The Effect of Optic Nerve Sheath Fenestration on Intraocular Pressure in Patients With Idiopathic Intracranial Hypertension.

J Neuroophthalmol 2022 03 12;42(1):97-100. Epub 2021 Apr 12.

Department of Ophthalmology (MM, WCF, RM), University of Texas Southwestern Medical Center and Parkland Memorial Hospital, Dallas, Texas; and Department of Ophthalmology (SS-K), Stony Brook University Medical Center, Stony Brook, New York.

Background: To evaluate the change in intraocular pressure (IOP) in patients with idiopathic intracranial hypertension (IIH) who underwent optic nerve sheath fenestration (ONSF) and to determine if radiographic evidence of posterior scleral or globe indentation influenced IOP.

Methods: This is a retrospective analysis of IOP in IIH patients who underwent ONSF. The study included all patients from September 2010 to March 2018 operated on by a single surgeon (R. Read More

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Predictive Value of International Classification of Diseases Codes for Idiopathic Intracranial Hypertension in a University Health System.

J Neuroophthalmol 2022 03;42(1):6-10

Department of Ophthalmology (FK, RK, IM, HEM), Stanford University, Palo Alto, California; and Department of Neurology & Neurological Sciences (HEM), Stanford University, Palo Alto, California.

Background: Misclassification bias is introduced into medical claims-based research because of reliance on diagnostic coding rather than full medical record review. We sought to characterize this bias for idiopathic intracranial hypertension (IIH) and evaluate strategies to reduce it.

Methods: A retrospective review of medical records was conducted using a clinical data warehouse containing medical records and administrative data from an academic medical center. Read More

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Idiopathic Intracranial Hypertension: Implications for the Otolaryngologist.

Otolaryngol Clin North Am 2022 Jun 27;55(3):579-594. Epub 2022 Apr 27.

Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1537 Norfolk Street, Suite 5800, Los Angeles, CA 90033, USA.

Idiopathic intracranial hypertension (IIH) is a triad of headaches, visual changes, and papilledema in the absence of a secondary cause for elevated intracranial pressure. There is an association with obesity, and the incidence is rising in parallel with the obesity epidemic. Sometimes these patients present to an otolaryngologist with complaints like tinnitus, dizziness, hearing loss, and otorrhea or rhinorrhea from cerebrospinal fluid leak. Read More

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Case of extensive cerebrospinal fluid leak postlumbar puncture in a paediatric patient with idiopathic intracranial hypertension.

BMJ Case Rep 2022 Apr 29;15(4). Epub 2022 Apr 29.

Paediatric Medicine, KK Women's and Children's Hospital, Singapore.

Lumbar punctures are frequently used in the diagnostic evaluation of central nervous system diseases such as infections, administration of medications such as chemotherapy and for reduction in intracranial pressure in cases of idiopathic intracranial hypertension. Cerebrospinal fluid (CSF) leak through a dural tear can result in temporary side effects such as headache (postlumbar puncture headache) and backache. Rarely, more severe side effects may occur with neurological deficits if there is an extensive CSF collection or epidural haematoma. Read More

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Pseudotumor Cerebri Syndrome With COVID-19: A Case Series.

J Neuroophthalmol 2022 Apr 27. Epub 2022 Apr 27.

Division of Neuro-ophthalmology (LM, EF, BKC), Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Division of Neuro-ophthalmology (MAB), Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Neurobiology (DHB, SRD), Harvard Medical School, Boston, Massachusetts; Division of Neuro-ophthalmology (SP), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and Department of Neurology (BKC), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome.

Cephalalgia 2022 Apr 25:3331024221094293. Epub 2022 Apr 25.

Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen.

Background: Our objective was to assess optic nerve sheath diameter (a marker of elevated intracranial pressure) and optic disc elevation (a marker of papilledema) in pseudotumor cerebri syndrome using transorbital sonography.

Methods: The study was a prospective case-control study. We included patients with new-onset pseudotumor cerebri syndrome and matched healthy controls. Read More

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Current Indications for Management Options in Pseudotumor Cerebri.

Neurol Clin 2022 05 31;40(2):391-404. Epub 2022 Mar 31.

Department of Neurological Surgery, The Ohio State University, N-1031 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address:

There are surgical options available for those patients with idiopathic intracranial hypertension (IIH) who have significant visual threat or visual deterioration despite best medical management or whose visual deterioration is rapid enough to warrant urgent intervention. Optic nerve sheath fenestrations, venous sinus stenting, and cerebrospinal fluid diversion via ventriculoperitoneal and lumboperitoneal shunting are useful adjuncts in the management of this condition. Significant resources are used in the care of patients with IIH. Read More

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Idiopathic intracranial hypertension and pregnancy: A comprehensive review of management.

Clin Neurol Neurosurg 2022 06 13;217:107240. Epub 2022 Apr 13.

Department of Clinical Neurosciences, Royal Infirmary of Edinburgh, Edinburgh, UK.

The management of IIH during pregnancy is a topic of clinical importance and it may pose a management challenge as most cases of IIH occur in women of childbearing age. Although there is a consensus that pregnant women with IIH should be treated similarly to non-pregnant patients, there are uncertainties regarding optimal management. This review aims to analyse current evidence and literature to help guide management of IIH during pregnancy. Read More

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[Fulminant idiopathic intracranial hypertension associated with macular atrophy: A case report].

J Fr Ophtalmol 2022 05 19;45(5):580-583. Epub 2022 Apr 19.

Service de médecine interne, centre hospitalo-universitaire, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.

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A Case of Idiopathic Intracranial Hypertension/Pseudotumor Cerebri Syndrome Cured by Myomectomy.

J Neuroophthalmol 2022 Mar 31. Epub 2022 Mar 31.

Department of Neurology, Princess Alexandra Hospital NHS Trust, Harlow, United Kingdom.

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Interdisciplinary Protocol for the Management of Vision-Threatening Papilledema.

J Neuroophthalmol 2022 Apr 19. Epub 2022 Apr 19.

Department of Ophthalmology and Visual Sciences (TB, SV, AVC, DM, BCKP, MDS, JEAW, KBD, BJK), John A Moran Eye Center, University of Utah, Salt Lake City, Utah; and Departments of Neurology (AVC, MDS, JEAW, KBD, BJK) and Neurosurgery (RHS), University of Utah, Salt Lake City, Utah.

Background: This study evaluates the effectiveness of a multidisciplinary protocol for management of patients with papilledema and vision loss secondary to increased intracranial pressure.

Methods: Retrospective record review of all adult patients who presented with vision-threatening papilledema (VTPE) and were treated under this protocol. Patients are admitted for lumbar drain placement and diuretics and followed daily to determine if they may be managed medically or require surgery (optic nerve sheath fenestration [ONSF] and/or cerebrospinal fluid [CSF] shunting). Read More

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Pseudotumor cerebri syndrome in children with systemic lupus erythematosus: case series and review.

Pediatr Rheumatol Online J 2022 Apr 15;20(1):29. Epub 2022 Apr 15.

Pediatric Rheumatology, Pediatrics, University of Chicago Medicine, Chicago, USA.

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that typically affects multiple organs and can lead to potentially fatal complications. Central nervous system (CNS) involvement in SLE is common, especially in children, and can present nonspecifically with various neuropsychiatric manifestations, described as neuropsychiatric SLE (NPSLE). Chronic headache is a common feature of NPSLE, secondary to increased intracranial pressure (also called pseudotumor cerebri (PTC)) due to inflammation or medication. Read More

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Increased Incidence of Pseudotumor Cerebri Syndrome Among Users of Tetracycline Antibiotics.

J Neuroophthalmol 2022 Mar 25. Epub 2022 Mar 25.

Department of Ophthalmology and Visual Sciences (SFP, RB, DRO, JEAW, AVC, BK, KBD, BJK), John A. Moran Eye Center, University of Utah, Salt Lake City, Utah; Department of Family and Preventive Medicine and Department of Orthopaedics (GJS), University of Utah, Salt Lake City, Utah; and Department of Biomedical Informatics and Center for Clinical and Translational Science (RG), University of Utah School of Medicine, Salt Lake City, Utah. Dr. Passi is now with the Eye Institute of Utah, Salt Lake City, UT. Dr. Butcher is now with the Data Science Services/Data Warehouse, Salt Lake City, Utah. Dr. Orme is now with the Department of Neurological Sciences, Rush University Medical Center, Chicago, IL. Dr. Kirk is now with the Department of Ophthalmology, University of Missouri School of Medicine, University Hospital, Columbia, MO.

Background: To determine whether the use of a tetracycline-class antibiotic is associated with an increased risk of developing pseudotumor cerebri syndrome (PTCS).

Methods: We identified patients in the University of Utah Health system who were prescribed a tetracycline-class antibiotic and determined what percentage of those individuals were subsequently diagnosed with PTCS secondary to tetracycline use. We compared this calculation to the number of patients with PTCS unrelated to tetracycline use. Read More

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Neurological Considerations for the Care of Patients With Severe Obesity.

Neurohospitalist 2022 Apr 25;12(2):264-267. Epub 2021 Aug 25.

Department of Neurology, MedStar Georgetown University Hospital, Washington, DC, USA.

Patients with severe obesity tend to have higher rates of morbidities which can complicate and even lengthen their hospital admission course. Hospitals which do not have the resources to efficiently manage bariatric patients due to equipment weight-restrictions should be proactive in their care and knowledgeable about their options to avoid long delays in treatment. Amid this obesity epidemic, the neurologist plays a role in the inpatient management of patients with severe obesity and could serve as a channel to improve the quality of care and reduce the length of stay. Read More

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[CME: Idiopathic Intracranial Hypertension].

Praxis (Bern 1994) 2022 Apr;111(5):250-258

Klinik für Neurologie, Universitätsspital Zürich und Universität Zürich, Zürich, Schweiz.

CME: Idiopathic Intracranial Hypertension Idiopathic intracranial hypertension is a pressure-induced secondary headache disorder and optic neuropathy. It primarily affects obese women of childbearing age and poses an interdisciplinary challenge both diagnostically and therapeutically. The most common symptom of this disorder are headaches frequently accompanied by photo- and/or phonophobia, whose semiology often resembles that of migraine, followed by transient visual obscurations and pulsatile tinnitus. Read More

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[Diagnosis and Therapy for Idiopathic Intracranial Hypertension].

Authors:
Yasushi Shibata

No Shinkei Geka 2022 Mar;50(2):455-466

Department of Neurosurgery, University of Tsukuba, Mito Medical Center, Mito Kyodo General Hospital.

Idiopathic intracranial hypertension is a pathological state of increased intracranial pressure without intracranial mass lesion, vascular lesion, or hydrocephalus. For the diagnosis of this pathology, various secondary and primary headaches, such as migraine and medication overuse headaches should be excluded. Radiological imaging, including diffusion tensor imaging may show secondary findings of intracranial hypertension. Read More

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Pseudotumor cerebri syndrome in children: Clinical characteristic and re-classification.

Brain Dev 2022 Aug 4;44(7):446-453. Epub 2022 Apr 4.

Department of Radiology, Faculty of Medicine, The University of Jordan.

Aim: To describe the clinical characteristics of children with pseudotumor cerebri syndrome (PTCS) who were diagnosed according to the modified Dandy criteria and to reclassify them according to the newly proposed diagnostic criteria by Freidman.

Methodology: This retrospective study included the period from January 2016-to July 2021.

Results: 50 patients were included; 34 males and 16 females with a male to female ratio of 2. Read More

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Pemetrexed-Induced Pseudotumor Cerebri Syndrome: A Rare Complication.

Ann Indian Acad Neurol 2021 Nov-Dec;24(6):947-949. Epub 2020 Nov 7.

Department of Neurology, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, India.

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November 2020

Treatment of Pseudotumor Cerebri (Sinus Stenosis).

Neurosurg Clin N Am 2022 Apr 2;33(2):207-214. Epub 2022 Mar 2.

Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA. Electronic address:

Idiopathic intracranial hypertension, pseudotumor cerebri, and benign intracranial hypertension are terms used to describe a neurologic syndrome characterized by elevated intracranial pressure, headache, vision loss, and absence of underlying mass lesion and infection. Increased cerebrospinal fluid (CSF) production has been proposed to play a role in this condition; however, in patients with CSF hypersecretion with known causes such as choroid plexus hyperplasia, patients often develop ventriculomegaly and hydrocephalus. Classically, pseudotumor cerebri is diagnosed as a triad of headache, visual changes, and papilledema. Read More

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