4,314 results match your criteria Pseudotumor Cerebri


Intracranial venous sinus stenting for the treatment of lateral sinus stenoses: An analysis of 200 patients.

Diagn Interv Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Interventional Neuroradiology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université de Paris, 75010 Paris, France.

Purpose: The purpose of this study was to analyze the long-term efficacy and safety of intracranial venous sinus stenting in a large cohort of patients with any type of presentation of primary lateral venous sinus stenosis (VSS).

Materials And Methods: A retrospective cohort study was performed including patients treated by venous sinus stenting for symptomatic VSS from 2012 to 2019. Successful primary resolution of symptoms without adjunctive treatment or recurrence, and complications after stenting were analyzed at the last follow-up time point. Read More

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Pseudotumor cerebri in the paediatric population: clinical features, treatment and prognosis.

Neurologia 2021 May 31. Epub 2021 May 31.

Unidad de Neurología Pediátrica. Unidad de Gestión Clínica de Pediatría y sus Especialidades. Hospital Universitario Reina Sofía, Córdoba, España; Grupo clínico vinculado al CIBERER, Área de Medicina Metabólica Hereditaria, Instituto de Salud Carlos III, Madrid, España; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, España.

Introduction: Pseudotumor cerebri (PC) in prepubertal patients displays certain characteristics that differentiate it from its presentation at the postpubertal stage. The aim of this study is to describe the characteristics of paediatric patients diagnosed with PC at our centre and to compare them according to their pubertal status.

Patients And Methods: We included patients aged between 1 and 18 years who were diagnosed with PC in a tertiary-level hospital between 2006 and 2019 and who met the updated diagnostic criteria for PC. Read More

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Current Perspectives on Idiopathic Intracranial Hypertension without Papilloedema.

Life (Basel) 2021 May 24;11(6). Epub 2021 May 24.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.

The pseudotumor cerebri syndrome embraces disorders characterised by raised intracranial pressure, where the commonest symptom is headache (90%). Idiopathic intracranial hypertension without papilloedema (IIHWOP) is increasingly recognised as a source of refractory headache symptoms and resultant neurological disability. Although the majority of patients with IIHWOP are phenotypically similar to those with idiopathic intracranial hypertension (IIH), it remains uncertain as to whether IIHWOP is nosologically distinct from IIH. Read More

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Intracranial Venous Hypertension and Venous Sinus Stenting in the Modern Management of Idiopathic Intracranial Hypertension.

Life (Basel) 2021 May 31;11(6). Epub 2021 May 31.

Department of Neurosurgery, Wake Forest University, Winston-Salem, NC 27101, USA.

Idiopathic intracranial hypertension (IIH) is a debilitating condition that has traditionally been difficult to treat. In recent years, there has been increasing focus on the role of intracranial venous hypertension in the pathophysiology of IIH. Based on increased understanding of this pathophysiology, venous sinus stenting (VSS) has emerged as a safe and reliable treatment for a certain population of patients with IIH. Read More

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Magnetic Resonance Imaging Features and Clinical Findings in Pediatric Idiopathic Intracranial Hypertension: A Case-Control Study.

Life (Basel) 2021 May 27;11(6). Epub 2021 May 27.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

The purpose of this study is to identify salient magnetic resonance imaging (MRI) findings of pediatric IIH, to determine the relevance of these findings with regard to disease pathogenesis, and to relate these findings to the clinical presentation towards identification of risk factors of disease. A retrospective, a case-control study of 38 pediatric patients with and 24 pediatric patients without IIH from the ophthalmology department at a tertiary care center was performed. Clinical data, including ophthalmic findings and lumbar puncture results, were recorded. Read More

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Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device.

Life (Basel) 2021 May 13;11(5). Epub 2021 May 13.

Medical Eye Unit, St Thomas' Hospital, London SE1 7EH, UK.

The photopic negative response (PhNR) is a negative component of the photopic flash electroretinogram that follows the b-wave and is thought to arise from the retinal ganglion cells. Reduction in its amplitude in idiopathic intracranial hypertension (IIH) has been previously documented using formal electroretinography. This study explored the use of a handheld device (RETeval, LKC technologies, Gaithersburg, MD, USA) in 72 IIH patients of varying stages and severity (and seven controls) and investigated associations between PhNR parameters and disease severity. Read More

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Idiopathic Intracranial Hypertension: Evaluation of Admissions and Emergency Readmissions through the Hospital Episode Statistic Dataset between 2002-2020.

Life (Basel) 2021 May 5;11(5). Epub 2021 May 5.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.

With increasing incidence and prevalence of Idiopathic intracranial hypertension in the UK, the aim of this study was to explore emerging themes in Idiopathic intracranial hypertension using the Hospital Episode Statistics dataset and to quantify recent change in hospital admissions and surgeries performed within England.

Methods: Hospital Episode Statistics national data was extracted between 1 April 2002 and 31 March 2019, and followed up until 31 March 2020. All those within England with a diagnosis of Idiopathic Intracranial Hypertension were included. Read More

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Outcomes measures in idiopathic intracranial hypertension.

Expert Rev Neurother 2021 Jun 7;21(6):687-700. Epub 2021 Jun 7.

Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, United Kingdom (UK).

: Idiopathic intracranial hypertension is a condition characterized by raised intracranial pressure, papilledema, and normal neuroimaging (aside from radiological signs of raised intracranial pressure). Symptoms of idiopathic intracranial hypertension include chronic headaches and for some, visual loss. New treatments are unmet clinical needs. Read More

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Benign intracranial hypertension associated with inhaled corticosteroids in a child with asthma.

BMJ Case Rep 2021 May 26;14(5). Epub 2021 May 26.

Department of Paediatrics, Children's Health Ireland at Tallaght University Hospital, Dublin, Ireland.

A 13-year-old male asthmatic presented to the general paediatric clinic with papilloedema identified following a check-up with his optician due to blurred vision. His asthma was well controlled on a moderate dose of inhaled corticosteroid and there had been no recent increase or decrease in the dose. A diagnosis of benign intracranial hypertension (BIH) was made based on a raised cerebrospinal fluid opening pressure, papilloedema, a normal neurological examination and normal neuroimaging. Read More

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In Reply: Prepontine Shunting for Pseudotumor Cerebri in Previously Failed Shunt Patients: A 5-Year Analysis.

Neurosurgery 2021 May 20. Epub 2021 May 20.

Department of Neurological Surgery Indiana University School of Medicine Indianapolis, Indiana, USA.

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Commentary: The role of inflammation in idiopathic intracranial hypertension.

Authors:
Padmaja Sudhakar

Indian J Ophthalmol 2021 06;69(6):1506-1507

Department of Ophthalmology and Neurology, University of Kentucky, Lexington, KY, USA.

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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammation markers in patients with papilledema due to idiopathic intracranial hypertension.

Indian J Ophthalmol 2021 06;69(6):1499-1505

Department of Radiology, Dıskapi Training and Research Hospital, Health Sciences University, Ankara, Turkey.

Purpose: The aim of this study was to investigate the role of inflammation in the pathogenesis of idiopathic intracranial hypertension (IIH) using the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammation markers.

Methods: The files of 33 IIH patients and 33 controls were screened for this retrospective study. For each patient, the NLR and PLR values were calculated using a single fasting blood sample. Read More

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Bilateral optic disc swelling resulting from lymphocytic meningitis and posterior uveitis secondary to syphilis.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Acute Medical Unit, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Idiopathic intracranial hypertension (IIH) is being diagnosed more often in the UK due to the rise in obesity. In fact, patients who present with bilateral optic disc swelling are habitually put on the papilloedema pathway, often without consideration of other diagnoses. We report the case of a middle-aged woman diagnosed with papilloedema and managed as IIH, until, cerebrospinal fluid (CSF) analysis revealed evidence of lymphocytic meningitis secondary to syphilis. Read More

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Vitamin A as a Cause of Pseudotumor Cerebri Syndrome: Not to Be Forgotten.

J Neuroophthalmol 2021 Apr 26. Epub 2021 Apr 26.

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama.

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Use of gonadotropin-releasing hormone analogs in children.

Curr Opin Pediatr 2021 May 17. Epub 2021 May 17.

Division of Endocrinology and Diabetes, Department of Pediatrics, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Purpose Of Review: In this review, we outline the usage and formulations of gonadotropin-releasing hormone analogs (GnRHas) in central precocious puberty (CPP), short stature, and gender diverse individuals, as well as adverse effects, long-term outcomes, and monitoring of therapy. There is a particular focus on citing references published within the last 24 months.

Recent Findings: Long-acting formulations of GnRHa now include Federal Drug Administration approval for subcutaneous injections. Read More

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MRI-findings in idiopathic intracranial hypertension (Pseudotumor cerebri).

Rofo 2021 May 12. Epub 2021 May 12.

Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein - Campus Kiel, Germany.

Background:  Pseudotumor cerebri, also known as idiopathic intracranial hypertension, is a disorder of increased intracranial pressure of unknown etiology. Main symptom is headache which has a characteristic similar to other headache diseases, therefore the idiopathic intracranial hypertension often remains undetected. The incidence is 1/100 000 with the number of unreported cases being much higher. Read More

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[Research Advances in Idiopathic Intracranial Hypertention].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):288-292

Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Idiopathic intracranial hypertension,also known as pseudotumor cerebri,is a syndrome characterized by raised intracranial pressure of unknown cause.These patients present normal neuroimaging and cerebrospinal fluid analysis while increased intracranial pressure and associated symptoms and signs.Delay of treatment can cause severe visual impairment. Read More

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The Health Economic Evaluation of Bariatric Surgery Versus a Community Weight Management Intervention Analysis from the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT).

Life (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

Background: The Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) established the efficacy of bariatric surgery as compared to a community weight management intervention in reducing intracranial pressure in active IIH. The aim of this cost-effectiveness analysis was to evaluate the economic impact of these weight loss treatments for IIH.

Methods: IIH:WT was a five-year randomised, controlled, parallel group, multicentre trial in the United Kingdom, where participants with active IIH and a body mass index ≥35 kg/m were randomly assigned (1:1) to receive access to bariatric surgery or a community weight management intervention. Read More

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Neurosurgical CSF Diversion in Idiopathic Intracranial Hypertension: A Narrative Review.

Life (Basel) 2021 Apr 26;11(5). Epub 2021 Apr 26.

Department of Paediatric Neurosurgery, Alder Hey Children's Hospital NHS Foundation Trust, Liverpool L12 2AP, UK.

The prevalence of idiopathic intracranial hypertension (IIH), a complex disorder, is increasing globally in association with obesity. The IIH syndrome occurs as the result of elevated intracranial pressure, which can cause permanent visual impairment and loss if not adequately managed. CSF diversion via ventriculoperitoneal and lumboperitoneal shunts is a well-established strategy to protect vision in medically refractory cases. Read More

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Space Flight-Associated Neuroocular Syndrome, Idiopathic Intracranial Hypertension, and Pseudotumor Cerebri: Phenotypic Descriptions, Pathogenesis, and Hydrodynamics.

Cureus 2021 Mar 25;13(3):e14103. Epub 2021 Mar 25.

Neurology, Flowers Medical Group, Dothan, USA.

Recent data from astronauts who have returned to Earth from a long-duration space flight have unequivocally distinguished spaceflight-associated neuro-ocular syndrome (SANS) from idiopathic intracranial hypertension (IIH) and pseudotumor cerebri (PTC). We review the semiology and pathogenesis of these three entities, noting that optic disc edema is what unites them, and this where the similarities between SANS and IIH/PTC end. We distinguish between PTC and IIH and between SANS and IIH/PTC and review the medical and surgical therapy of IIH/PTC. Read More

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Intracranial Access: Dural Venous Sinus Stenting: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Apr 23. Epub 2021 Apr 23.

Department of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, USA.

Cerebral venous sinus stenting has gained popularity in recent years as a safe and efficacious treatment of selected patients with idiopathic intracranial hypertension (IIH) and focal venous sinus stenosis.1-3 The main goal of treatment is to prevent visual loss, and often patients report resolution of headache and visual symptoms within 21 mo of mean follow-up.4-8 We present the case of a 57-yr-old woman with medically refractory IIH, bilateral sinus stenosis, and a mass lesion causing stenosis on the left. Read More

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Experience With Ventriculoperitoneal and Lumboperitoneal Shunting for the Treatment of Idiopathic Intracranial Hypertension: A Single Institution Series.

Oper Neurosurg (Hagerstown) 2021 Apr 22. Epub 2021 Apr 22.

Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA.

Background: CSF shunting is among the most widely utilized interventions in patients with idiopathic intracranial hypertension (IIH). Ventriculoperitoneal shunting (VPS) and lumboperitoneal shunting (LPS) are 2 possible treatment modalities.

Objective: To evaluate and compare complications, malfunction, infection, and revision rates associated with VPS compared to LPS. Read More

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Factors Predisposing to Post Dural Puncture Headache in Children.

J Child Neurol 2021 Apr 21:8830738211007699. Epub 2021 Apr 21.

2969Children's Hospital of MI, Detroit, MI, USA.

Background: Knowledge of the factors that predispose to postdural puncture headache in children may help reduce the occurrence of this complication.

Materials And Methods: A retrospective cohort study of children who presented to the study institution between 2010 and 2018 was conducted. Children were divided into 2 groups: those who experienced postdural puncture headache and those who did not. Read More

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Pseudotumor Cerebri Syndrome Complicated by Diffuse Ophthalmoparesis and Polyradiculopathy.

Neurohospitalist 2021 Jan 3;11(1):71-74. Epub 2020 Aug 3.

University of Pennsylvania, Philadelphia, PA, USA.

Pseudotumor cerebri syndrome (PTCS), also known as idiopathic intracranial hypertension (IIH), is defined by elevated intracranial pressure in the absence of a structural or cerebrospinal fluid (CSF) abnormality. Typical features include headache, visual symptoms, and pulsatile tinnitus. Cranial nerve deficits are seen in a minority of cases, most often sixth nerve palsies. Read More

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January 2021

Noninvasive Intracranial Pressure Assessment in Patients with Suspected Idiopathic Intracranial Hypertension.

Acta Neurochir Suppl 2021 ;131:325-327

Department of Neurology, Chemnitz Medical Centre, Chemnitz, Germany.

Introduction: Idiopathic intracranial hypertension (IIH) usually occurs in obese women of childbearing age. Typical symptoms are headache and sight disorders. Besides ophthalmoscopy, lumbar puncture is used for both diagnosis and therapy of IIH. Read More

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Telemetric Intracranial Pressure: A Snapshot Does not Give the Full Story.

Acta Neurochir Suppl 2021 ;131:323-324

Institute of Neurological Sciences, Royal Hospital for Children, Glasgow, UK.

Telemetric intracranial pressure (ICP) monitors are useful tools in the management of complex hydrocephalus and idiopathic intracranial hypertension (IIH). Clinicians may use them as a "snapshot" screening tool to assess shunt function or ICP. We compared "snapshot" telemetric ICP recordings with extended, in-patient periods of monitoring to determine whether this practice is safe and useful for clinical decision making. Read More

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Transcranial Doppler Plateau Wave in a Patient with Pseudo-Chiari Malformation.

Acta Neurochir Suppl 2021 ;131:319-322

Intensive Care Unit, Clinicas Hospital School of Medicine, University of the Republic, Montevideo, Uruguay.

Case Report: A 26-year-old woman presented a superior sagittal and transverse sinus thrombosis with venous infarction. Anticoagulation was started. Six months later headache and visual impairment developed, and intracranial hypertension was diagnosed-secondary pseudotumor cerebri. Read More

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Analysis of the Peripapillary Choroidal Vascular Characteristics in Papilledema Associated with Pseudotumor Cerebri.

Optom Vis Sci 2021 04;98(4):326-333

Department of Ophthalmology, Selcuk University School of Medicine, Konya, Turkey.

Significance: Choroidal vascularity index measured by image binarization method from peripapillary optical coherence tomography sections has been found significantly lower in papilledema patients than healthy controls.

Purpose: The purpose of this study was to compare peripapillary choroidal parameters in papilledema patients with control subjects.

Methods: Peripapillary spectral domain optical coherence tomography scans of 34 patients with papilledema and 34 healthy controls are acquired for the study. Read More

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Single Arm Access for Combined Transarterial and Transvenous Neurointerventional Procedures.

World Neurosurg 2021 Jun 31;150:121-126. Epub 2021 Mar 31.

Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

A concurrent arterial and venous access is routinely obtained for diagnosis and treatment of various neurovascular diseases. Traditionally, venous access is obtained by accessing the femoral vein or through direct internal jugular puncture. Although complication rates are low, life-threatening severe complications have been reported. Read More

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