185 results match your criteria Pseudoporphyria


A Case of Voriconazole-Induced Pseudoporphyria.

J Allergy Clin Immunol Pract 2018 Sep 25. Epub 2018 Sep 25.

Division of Allergy and Clinical Immunology, Department of Medicine, East Tennessee State University, Johnson City, Tenn. Electronic address:

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September 2018

N-acetylcysteine in dermatology.

Indian J Dermatol Venereol Leprol 2018 Nov-Dec;84(6):652-659

Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

N-acetylcysteine is a mucolytic drug which is commonly used as an antidote for acetaminophen toxicity. It is a thiol compound, which acts as a donor of cysteine, leading to replenishment of glutathione and thus acts as an antioxidant. It also has anti-inflammatory effects, alters the levels of neurotransmitters, inhibits proliferation of fibroblasts and keratinocytes and causes vasodilatation. Read More

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September 2018
7 Reads

Direct Immunofluorescence of Mechanobullous Epidermolysis Bullosa Acquisita, Porphyria Cutanea Tarda and Pseudoporphyria.

Acta Derm Venereol 2018 Sep 3. Epub 2018 Sep 3.

Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, Hanzeplein 1, NL-9700 RB Groningen, The Netherlands.

Mechanobullous epidermolysis bullosa acquisita (mEBA) can have a clinical presentation that is very similar to other blistering diseases, such as porphyria cutanea tarda (PCT) and pseudoporphyria. Direct immunofluorescence is an important feature in the diagnosis of mEBA, although features that overlap with PCT and pseudoporphyria have been reported. This retrospective observational study investigated whether direct immunofluorescence can discriminate mEBA from PCT and pseudoporphyria. Read More

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September 2018
2 Reads

Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report.

J Bras Nefrol 2018 Jul 10. Epub 2018 Jul 10.

Departamento de Nefrologia, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.

Introduction: Pseudoporphyria is a rare photodermatosis with characteristics similar to those of porphyria cutanea tarda, without, however, presenting abnormalities in porphyrin metabolism. Its etiology is related to chronic kidney disease, ultraviolet radiation and certain medications. The aim of the present study is to describe a case of furosemide-related pseudoporphyria in a patient with chronic kidney disease. Read More

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July 2018
6 Reads

Photoonycholysis: new findings.

J Eur Acad Dermatol Venereol 2018 Jun 28. Epub 2018 Jun 28.

Photodermatology Department, Hospital Clinic de Barcelona, Barcelona, Spain.

First described in 1961, photoonycholysis (PO) is a rare nail alteration that may result from drug intake, from topical aminolevulinate photodynamic therapy or from photosensitive conditions such as porphyria or pseudoporphyria. Spontaneous PO is rare. This review updates the numerous causes of PO and highlights some new ways producing this condition. Read More

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Blisters Induced by PUVA: A Report of 5 Cases.

Actas Dermosifiliogr 2018 Oct;109(8):e11-e16

Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón, Asturias, España.

Blisters associated with PUVA treatments are an adverse effect of photochemotherapy that has been reported in the literature. Asymptomatic blisters appear spontaneously mainly on the lower limbs and resolve without treatment. The differential diagnoses to consider include a phototoxic reaction, pseudoporphyria, and PUVA-induced bullous pemphigoid. Read More

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October 2018
1 Read

Bullosis Diabeticorum: A Rare Presentation with Immunoglobulin G (IgG) Deposition Related Vasculopathy. Case Report and Focused Review.

Am J Case Rep 2018 Jan 15;19:52-56. Epub 2018 Jan 15.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

BACKGROUND Bullosis diabeticorum (BD) is a condition characterized by recurrent, spontaneous, and non-inflammatory blistering in patients with poorly controlled diabetes mellitus. While etiopathogenesis remains unclear, roles of neuropathy, vasculopathy and UV light are hypothesized. Most literature reports negative direct and indirect immunofluorescence findings in diabetics with bullous eruptions. Read More

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January 2018
6 Reads

Imatinib-induced pseudoporphyria.

Clin Exp Dermatol 2018 Jun 8;43(4):463-466. Epub 2018 Jan 8.

Department of Dermatology, Hospital Universitario de La Princesa, Diego de León 62, Madrid, 28006, Spain.

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June 2018
25 Reads

Porphyria cutanea tarda: an intriguing genetic disease and marker.

Int J Dermatol 2017 Jun 21;56(6):e106-e117. Epub 2017 Mar 21.

Dermatology, Rutgers New Jersey Medical School, Newark, NJ, USA.

Porphyrias are a group of intriguing genetic diseases of the heme pathway, of which porphyria cutanea tarda (PCT) is the most common. Resulting from a defect in enzymes in the porphyria pathway, PCT has been linked to several conditions. Recent studies have demonstrated a change in thinking regarding the human immunodeficiency virus (HIV) and development of PCT. Read More

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June 2017
5 Reads

Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a thorough conformational and binding analysis for ROR-γ protein.

J Biomol Struct Dyn 2018 02 16;36(2):335-350. Epub 2017 Jan 16.

a Molecular Modelling and Drug Design Research Group, School of Health Sciences, University of KwaZulu-Natal , Westville , Durban 4000 , South Africa.

Recent studies have linked a deadly form of prostate cancer known as metastatic castration-resistant prostate cancer to retinoic acid-related orphan-receptor gamma (ROR-γ). Most of these studies continued to place ROR-γ as orphan because of unidentifiable inhibitor. Recently identified inhibitors of ROR-γ and their therapeutic potential were evaluated, among which inhibitor XY018 was the potent. Read More

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February 2018
4 Reads

Development of bullous pemphigoid during the haemodialysis of a young man: case report and literature survey.

Int Wound J 2017 Feb 17;14(1):288-292. Epub 2016 Oct 17.

Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.

Haemodialysis is the most frequent form of renal replacement therapy (RRT) in patients with end-stage renal disorder (ESRD). Patients with ESRD frequently develop skin problems, mainly xerosis, pruritus and hyperpigmentation, as well as bullous diseases, mainly porphyria or pseudoporphyria and, in some cases, bullous pemphigoid (BP). BP is the most common autoimmune sub-epidermal blistering disease, and it predominantly affects elderly people. Read More

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February 2017
13 Reads

Imatinib mesylate-induced pseudoporphyria in a patient with chronic myeloid leukemia.

Indian J Dermatol Venereol Leprol 2016 Nov-Dec;82(6):727-729

Department of Dermatology, Fortis Hospital, New Delhi, India.

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May 2017
7 Reads

Acquired reactive perforating collagenosis and pseudoporphyric bullous dermatosis in a hemodialysis patient.

Hemodial Int 2016 Jul 2;20(3):E14-E18. Epub 2016 Feb 2.

Department of Pathology, General Hospital Hippokrateion, Thessaloniki, Greece.

Hemodialysis patients present with a broad spectrum of specific and nonspecific skin disorders, which rarely coexist. We report an exceptional case of a hemodialysis patient that developed acquired reactive perforating collagenosis and pseudoporphyric bullous dermatosis on the basis of common skin disorders which include hyperpigmentation, pruritus, xerosis cutis, and Linsday's nails. Interestingly, our patient presented with two unusual but distinctive cutaneous dermopathies on the background of other commonly seen skin alterations. Read More

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July 2016
10 Reads

Drug induced pseudoporphyria in CKD: A case report.

Indian J Nephrol 2015 Sep-Oct;25(5):307-9

Department of Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Pseudoporphyria (PP) is used to describe a photodistributed bullous disorder with clinical and histologic features of porphyria cutanea tarda (PCT) but without accompanying biochemical porphyrin abnormalities. Medications, excessive sun and ultraviolet radiation exposure, have all been reported to develop PP. We report a case of PP in a 49-year-old man with CKD stage 3a, caused due to torsemide intake. Read More

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December 2015
25 Reads

Phototoxicity, Pseudoporphyria, and Photo-onycholysis Due to Voriconazole in a Pediatric Patient With Leukemia and Invasive Aspergillosis.

J Pediatric Infect Dis Soc 2015 Jun 4;4(2):e22-4. Epub 2014 Jul 4.

Infectious Diseases Division, Department of Pediatrics.

Voriconazole is a triazole antifungal agent superior to amphotericin B in the treatment of invasive aspergillosis. It is generally well tolerated and has excellent oral bioavailability, providing significant benefit in the treatment of invasive fungal infections. There have been numerous reports of dermatologic reactions to this agent, including erythroderma, cheilitis, Stevens-Johnson syndrome, discoid lupus erythematosus, pseudoporphyria, squamous cell carcinoma, and photosensitivity reactions. Read More

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June 2015
4 Reads

Pseudoporphyria: A Case Report.

Indian J Dermatol 2015 May-Jun;60(3):324

Department of Pathology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

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June 2015
5 Reads

Dialysis-associated pseudoporphyria successfully treated with vitamin D. Report of two cases.

G Ital Dermatol Venereol 2015 Jun;150(3):327-9

Unit of Dermatology, NESMOS Department, Faculty of Medicine, Sant'Andrea" Hospital "Sapienza" University, Rome, Italy -

Pseudoporphyria refers to a rare bullous dermatosis characterized by the clinical and histological features of porfiria cutanea tarda without abnormalities in porphyrin metabolism. The pathogenesis is heterogeneous and several exogenous factors may promote the bullous lesion formation, including medications, end stage renal disease, dialysis and tanning beds. Regarding treatment of this condition, in literature different therapy have been reported, such as glutathione and his precursor N-acetylcysteine, which presents anti-oxidant properties; however even more toxic drugs, such as chloroquine, are used. Read More

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June 2015
8 Reads

Effect of tetracycline and UV radiation on melanization and antioxidant status of melanocytes.

J Photochem Photobiol B 2015 Jul 27;148:168-173. Epub 2015 Apr 27.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Silesia, Jagiellońska 4, PL 41-200 Sosnowiec, Poland.

Tetracycline is a semisynthetic antibiotic and is used in several types of infections against both gram-positive and gram-negative bacteria. This therapy is often associated with phototoxic reactions that occur after exposure to UV radiation and lead to photo-onycholysis, pseudoporphyria, solar urticaria and the fixed drug eruption in the skin. The phototoxic reactions may be related to the melanin content which, on one side may bind drugs - leading to their accumulation, and on the other side, they have photoprotective and antioxidant properties. Read More

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July 2015
9 Reads

[Medicine-caused itch, wounds and bullous skin in three patients with pseudoporphyria].

Ugeskr Laeger 2015 Apr;177(17)

Dansk BørneAstma Center, Ledreborg Alle 34, 2850 Gentofte.

Pseudoporphyria cutanea tarda is a well described bullous skin disorder which resembles porphyria cutanea tarda. However, the levels of porphyrins in plasma, urine and faeces are normal. We present three cases of patients with classical symptoms of pseudoporphyria. Read More

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April 2015
39 Reads

Pseudoporphyria in a peritoneal dialysis patient.

Perit Dial Int 2015 Mar-Apr;35(2):234-5

Department of Internal Medicine, Division of Nephrology, Marmara University, School of Medicine, Istanbul, Turkey.

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April 2016
13 Reads

Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients.

J Eur Acad Dermatol Venereol 2016 Jul 16;30(7):1239-42. Epub 2015 Apr 16.

Dermatology, St George Hospital, Sydney, Australia.

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July 2016
2 Reads

[Clinical review of pseudoporphyria].

Ugeskr Laeger 2015 Feb;177(6)

Medicinsk Afdeling, Odense Universitetshospital, Svendborg Sygehus, Valdemarsgade 53, 5700 Svendborg.

Pseudoporphyria is a photosensitive bullous disease, which resembles porphyria cutanea tarda. Normal porphyrin levels in urine, stool and blood define pseudoporphyria. Pseudoporphyria is associated with chronic renal failure, haemodialysis, a variety of drugs (e. Read More

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February 2015
5 Reads

[Adverse effects of Sutent(®): pseudoporphyria and scrotal necrosis].

Authors:
J-L Schmutz

Ann Dermatol Venereol 2014 Dec 18;141(12):815-6. Epub 2014 Oct 18.

Département de dermatologie et allergologie, bâtiment des spécialités médicales, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address:

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December 2014
2 Reads

Photosensitization by imatinib. A photochemical and photobiological study of the drug and its substructures.

Chem Res Toxicol 2014 Nov 14;27(11):1990-5. Epub 2014 Oct 14.

Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València , Avda de los Naranjos s/n, 46022 Valencia, Spain.

Imatinib (IMT) is a promising tyrosine kinase inhibitor used in the treatment of some types of human cancer. It constitutes a successful example of rational drug design based on the optimization of the chemical structure to reach an improved pharmacological activity. Cutaneous reactions, such as increased photosensitivity or pseudoporphyria, are among the most common nonhematological IMT side effects; however, the molecular bases of these clinical observations have not been determined. Read More

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November 2014
6 Reads

Accelerated photoaging induced by voriconazole treated with Q-switched Nd:YAG laser: case report and review of the literature.

J Cosmet Laser Ther 2014 Dec 25;16(6):314-6. Epub 2014 Sep 25.

Department of Dermatology, Clínica Universidad de Navarra , Pamplona , Spain.

Voriconazole is an antifungal agent mainly used against aspergillosis. Given its wide spectrum of action and limited adverse effects, it has replaced amphotericin B as the drug of choice in the prophylactic treatment of immunocompromised patients. Several adverse effects are caused by this drug with dermatological reactions accounting for 6% of the total. Read More

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December 2014
9 Reads

Pseudoporphyria following self-medication with chlorophyll.

Australas J Dermatol 2015 Feb 15;56(1):47-8. Epub 2014 Aug 15.

Pathwest Laboratory Medicine, QE II Medical Centre, Australia.

Two cases of pseudoporphyria are described in which the clinical features of porphyria cutanea tarda occurred in the absence of abnormalities in porphyrin metabolism. Both patients presented with skin fragility and bullae on the dorsal aspect of the hands. The patients consumed a commercial liquid chlorophyll drink in which we detected fluorescent compounds with characteristics typical of previously described chlorophyll derived photosensitisers. Read More

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February 2015
8 Reads

Pseudoporphyria: discussion of etiologic agents.

J Drugs Dermatol 2014 Aug;13(8):990-2

Pseudoporphyria describes a photodistributed bullous disorder with negative urinary, fecal, and serum porphyrin studies. Although pseudoporphyria is thought to be extremely rare (less than 100 reported cases4-5), we propose that this entity is underreported. One author (KB) has seen four cases of pseudoporphyria in the past four years. Read More

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August 2014
2 Reads

Imatinib mesylate-induced pseudoporphyria in two children.

Pediatr Dermatol 2014 Sep-Oct;31(5):603-7. Epub 2014 Jun 12.

Department of Paediatric Dermatology, Starship Children's Health, Auckland, New Zealand.

Imatinib mesylate was the first of several tyrosine kinase inhibitors approved for use in the treatment of a number of human cancers. Adverse cutaneous reactions to imatinib are common. Pseudoporphyria has been infrequently reported in adults undergoing imatinib therapy for chronic myeloid leukemia. Read More

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May 2015
3 Reads

Sunitinib-induced pseudoporphyria.

J Eur Acad Dermatol Venereol 2015 Sep 12;29(9):1848-50. Epub 2014 May 12.

Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain.

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September 2015
3 Reads

Pseudoporphyria induced by hemodialysis.

Postepy Dermatol Alergol 2014 Feb 25;31(1):53-5. Epub 2014 Feb 25.

Department of Dermatology, Silesian Medical University, Katowice, Poland. Head of Department: Prof. Ligia Brzezińska-Wcisło MD, PhD.

Pseudoporphyria is a condition identical to porphyria cutanea tarda (PCT) on clinical and histological grounds, but without any biochemical porphyrin abnormality. Excessive sunlight and UVA exposure (for example tanning beds), drugs such as: non-steroidal anti-inflammatory drugs, retinoids, antibiotics, diuretics and others are supposed to be etiological factors of pseudoporphyria. Cases of PCT and pseudoporphyria in patients with HCV infection and hemodialysed due to chronic renal failure were also described. Read More

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February 2014
3 Reads

Diclofenac-induced pseudoporphyria; an under-recognized condition?

Clin Exp Dermatol 2014 Apr;39(3):348-50

Pathology Department, Warwick Hospital, Warwick, UK.

Pseudoporphyria is a photodistributed bullous disorder that is clinically and histologically similar to porphyria cutanea tarda (PCT), but without abnormal porphyrin biochemistry. Renal failure, dialysis, excessive ultraviolet A and medications, particularly nonsteroidal anti-inflammatory drugs (NSAIDs), have been associated with pseudoporphyria. We report a case of diclofenac-induced pseudoporphyria in a man with psoriatic arthritis. Read More

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April 2014
3 Reads

Pseudoporphyria - a case report.

J Eur Acad Dermatol Venereol 2015 Apr 11;29(4):827. Epub 2014 Mar 11.

Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

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April 2015
1 Read

Pseudoporphyria associated with nonhemodialyzed renal insufficiency, successfully treated with oral N-acetylcysteine.

Case Rep Dermatol Med 2013 10;2013:271873. Epub 2013 Apr 10.

Second Department of Dermatology, "Attikon" General University Hospital, University of Athens, 1 Rimini Street, 124 62 Chaidari, Greece.

Pseudoporphyria (PP) is a relatively rare, photodistributed bullous dermatosis that resembles porphyria cutanea tarda (PCT), but it is not accompanied by porphyrin abnormalities in the serum, urine, or stool. It was initially described in renal failure patients on dialysis. Thereafter, it has been associated with several aetiological factors. Read More

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May 2013
3 Reads

Pseudoporphyria induced by imatinib mesylate.

Int J Dermatol 2014 Feb 3;53(2):e143-4. Epub 2013 Mar 3.

Department of Dermatology Hospital Donostia San Sebastian Spain E-mail:

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February 2014
2 Reads

Metformin-induced pseudoporphyria.

J Drugs Dermatol 2012 Nov;11(11):1272

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November 2012
6 Reads

Diagnosis of common dermopathies in dialysis patients: a review and update.

Semin Dial 2012 Jul;25(4):408-18

Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.

Cutaneous abnormalities in patients with end-stage renal disease (ESRD) receiving hemodialysis or peritoneal dialysis may demonstrate signs of their underlying condition or reveal associated disease entities. While a thorough examination of the scalp, skin, mucosa, and nails is integral to establishing a diagnosis, certain conditions will resolve only with dialysis or improvement of their renal disease and others may not require or respond to treatment. Half and half nails, pruritus, xerosis, and cutaneous hyperpigmentation are common manifestations in ESRD. Read More

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July 2012
5 Reads

Cutaneous changes in patients with chronic renal failure on hemodialysis.

Cutan Ocul Toxicol 2012 Dec 15;31(4):286-91. Epub 2012 Feb 15.

Department of Dermatology, Yenisehir State Hospital, Kahramanmaras, Turkey.

Context: A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series.

Objective: To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the patients. Read More

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December 2012
3 Reads

Pseudoporphyria induced by dialysis treated with oral N-acetylcysteine.

An Bras Dermatol 2011 Mar-Apr;86(2):383-5

Departamento de Dermatologia e Radioterapia, Faculdade de Medicina, Universidade Paulista Julio de Mesquita Filho, Botucatu, SP, Brasil.

Pseudoporphyria is a rare bullous dermatosis that clinically and histopathologically is similar to porphyria cutanea tarda. It mainly affects patients with chronic renal failure on peritoneal dialysis or hemodialysis. Medications can also be involved in the etiology. Read More

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January 2012
3 Reads

Hemodialysis-associated pseudoporphyria resistant to N-acetylcysteine.

Saudi J Kidney Dis Transpl 2011 Mar;22(2):311-4

Service of Nephrology, Haemodialysis and Kidney Transplantation, Military Hospital, Mohammed V, Rabat, Morocco.

We report a 33-year-old female patient who had hemodialysis-associated pseudoporphyria which did not respond to treatment with oral N-acetylcysteine. She responded favorably to treatment with the anti-malarial drug, chloroquine. The case is being reported to highlight the difficulty in interpreting the urinary porphyrin assays in patients on hemodialysis. Read More

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March 2011
5 Reads

Voriconazole-associated phototoxicity.

Dermatol Online J 2011 Feb 15;17(2):15. Epub 2011 Feb 15.

Voriconazole is an extended-spectrum triazole antifungal approved for treatment of invasive fungal infections. The drug has been associated with phototoxicity, presenting as photodistributed eruptions such as macular erythema or pseudoporphyria. We describe a 59-year-old man with acute myeloid leukemia, status-post matched unrelated donor stem cell transplant, who developed fungal pneumonia and was placed on posaconazole. Read More

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February 2011
4 Reads

Pseudoporphyria associated with hemodialysis.

Kidney Int 2011 Jan;79(1):140

Department of Clinical Medicine, Federal University of Rio Grande do Norte, Hospital Universitário Onofre Lopes, Natal, Brazil.

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January 2011
2 Reads

Pseudoporphyria in a haemodialysis patient.

NDT Plus 2010 Dec 24;3(6):592-3. Epub 2010 Aug 24.

Department of Nephrology , Chang Gung Memorial Hospital , Taipei , Taiwan ; College of Medicine , Chang Gung University , Taoyuan , Taiwan.

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December 2010
3 Reads

Imatinib mesylate-induced pseudoporphyria.

J Am Acad Dermatol 2010 Jul;63(1):e14-6

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July 2010
2 Reads

Melanoma associated with long-term voriconazole therapy: a new manifestation of chronic photosensitivity.

Arch Dermatol 2010 Mar 18;146(3):300-4. Epub 2010 Jan 18.

Department of Dermatology, University of California-San Francisco, 1701 Divisadero St., San Francisco, CA 94143, USA.

Background: Voriconazole is a triazole antifungal agent approved by the US Food and Drug Administration for serious fungal infections, including with Aspergillus, Fusarium, Pseudallescheria, and Scedosporium species. In initial clinical trials, approximately 2% of patients developed cutaneous reactions, including photosensitivity, cheilitis, and xerosis. Subsequent reports have implicated voriconazole as a cause of severe photosensitivity and accelerated photoaging, pseudoporphyria cutanea tarda, and aggressive squamous cell carcinoma. Read More

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March 2010
14 Reads

[Solarium-induced pseudoporphyria and variegate porphyria as rare differential diagnoses of porphyria cutanea tarda].

Hautarzt 2009 Oct;60(10):790-3

Hautklinik des Universitätsklinikums Düsseldorf.

Three patients presented with typical porphyria cutanea tarda-like vesicles, erosions and scars as well as increased fragility, primarily on the back of the hands. In two of the three, porphyrin workup was normal. Skin biopsy was compatible with porphyria cutanea tarda (PCT) or pseudoporphyria. Read More

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October 2009
4 Reads