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    177 results match your criteria Pseudoporphyria

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    Porphyria cutanea tarda: an intriguing genetic disease and marker.
    Int J Dermatol 2017 Jun 21;56(6):e106-e117. Epub 2017 Mar 21.
    Dermatology, Rutgers New Jersey Medical School, Newark, NJ, USA.
    Porphyrias are a group of intriguing genetic diseases of the heme pathway, of which porphyria cutanea tarda (PCT) is the most common. Resulting from a defect in enzymes in the porphyria pathway, PCT has been linked to several conditions. Recent studies have demonstrated a change in thinking regarding the human immunodeficiency virus (HIV) and development of PCT. Read More

    Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a thorough conformational and binding analysis for ROR-γ protein.
    J Biomol Struct Dyn 2017 Jan 16:1-16. Epub 2017 Jan 16.
    a Molecular Modelling and Drug Design Research Group, School of Health Sciences, University of KwaZulu-Natal , Westville , Durban 4000 , South Africa.
    Recent studies have linked a deadly form of prostate cancer known as metastatic castration-resistant prostate cancer to retinoic acid-related orphan-receptor gamma (ROR-γ). Most of these studies continued to place ROR-γ as orphan because of unidentifiable inhibitor. Recently identified inhibitors of ROR-γ and their therapeutic potential were evaluated, among which inhibitor XY018 was the potent. Read More

    Development of bullous pemphigoid during the haemodialysis of a young man: case report and literature survey.
    Int Wound J 2017 Feb 17;14(1):288-292. Epub 2016 Oct 17.
    Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.
    Haemodialysis is the most frequent form of renal replacement therapy (RRT) in patients with end-stage renal disorder (ESRD). Patients with ESRD frequently develop skin problems, mainly xerosis, pruritus and hyperpigmentation, as well as bullous diseases, mainly porphyria or pseudoporphyria and, in some cases, bullous pemphigoid (BP). BP is the most common autoimmune sub-epidermal blistering disease, and it predominantly affects elderly people. Read More

    Acquired reactive perforating collagenosis and pseudoporphyric bullous dermatosis in a hemodialysis patient.
    Hemodial Int 2016 Jul 2;20(3):E14-E18. Epub 2016 Feb 2.
    Department of Pathology, General Hospital Hippokrateion, Thessaloniki, Greece.
    Hemodialysis patients present with a broad spectrum of specific and nonspecific skin disorders, which rarely coexist. We report an exceptional case of a hemodialysis patient that developed acquired reactive perforating collagenosis and pseudoporphyric bullous dermatosis on the basis of common skin disorders which include hyperpigmentation, pruritus, xerosis cutis, and Linsday's nails. Interestingly, our patient presented with two unusual but distinctive cutaneous dermopathies on the background of other commonly seen skin alterations. Read More

    Drug induced pseudoporphyria in CKD: A case report.
    Indian J Nephrol 2015 Sep-Oct;25(5):307-9
    Department of Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
    Pseudoporphyria (PP) is used to describe a photodistributed bullous disorder with clinical and histologic features of porphyria cutanea tarda (PCT) but without accompanying biochemical porphyrin abnormalities. Medications, excessive sun and ultraviolet radiation exposure, have all been reported to develop PP. We report a case of PP in a 49-year-old man with CKD stage 3a, caused due to torsemide intake. Read More

    Phototoxicity, Pseudoporphyria, and Photo-onycholysis Due to Voriconazole in a Pediatric Patient With Leukemia and Invasive Aspergillosis.
    J Pediatric Infect Dis Soc 2015 Jun 4;4(2):e22-4. Epub 2014 Jul 4.
    Infectious Diseases Division, Department of Pediatrics.
    Voriconazole is a triazole antifungal agent superior to amphotericin B in the treatment of invasive aspergillosis. It is generally well tolerated and has excellent oral bioavailability, providing significant benefit in the treatment of invasive fungal infections. There have been numerous reports of dermatologic reactions to this agent, including erythroderma, cheilitis, Stevens-Johnson syndrome, discoid lupus erythematosus, pseudoporphyria, squamous cell carcinoma, and photosensitivity reactions. Read More

    Dialysis-associated pseudoporphyria successfully treated with vitamin D. Report of two cases.
    G Ital Dermatol Venereol 2015 Jun;150(3):327-9
    Unit of Dermatology, NESMOS Department, Faculty of Medicine, Sant'Andrea" Hospital "Sapienza" University, Rome, Italy -
    Pseudoporphyria refers to a rare bullous dermatosis characterized by the clinical and histological features of porfiria cutanea tarda without abnormalities in porphyrin metabolism. The pathogenesis is heterogeneous and several exogenous factors may promote the bullous lesion formation, including medications, end stage renal disease, dialysis and tanning beds. Regarding treatment of this condition, in literature different therapy have been reported, such as glutathione and his precursor N-acetylcysteine, which presents anti-oxidant properties; however even more toxic drugs, such as chloroquine, are used. Read More

    Effect of tetracycline and UV radiation on melanization and antioxidant status of melanocytes.
    J Photochem Photobiol B 2015 Jul 27;148:168-173. Epub 2015 Apr 27.
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Silesia, Jagiellońska 4, PL 41-200 Sosnowiec, Poland.
    Tetracycline is a semisynthetic antibiotic and is used in several types of infections against both gram-positive and gram-negative bacteria. This therapy is often associated with phototoxic reactions that occur after exposure to UV radiation and lead to photo-onycholysis, pseudoporphyria, solar urticaria and the fixed drug eruption in the skin. The phototoxic reactions may be related to the melanin content which, on one side may bind drugs - leading to their accumulation, and on the other side, they have photoprotective and antioxidant properties. Read More

    [Medicine-caused itch, wounds and bullous skin in three patients with pseudoporphyria].
    Ugeskr Laeger 2015 Apr;177(17)
    Dansk BørneAstma Center, Ledreborg Alle 34, 2850 Gentofte.
    Pseudoporphyria cutanea tarda is a well described bullous skin disorder which resembles porphyria cutanea tarda. However, the levels of porphyrins in plasma, urine and faeces are normal. We present three cases of patients with classical symptoms of pseudoporphyria. Read More

    [Clinical review of pseudoporphyria].
    Ugeskr Laeger 2015 Feb;177(6)
    Medicinsk Afdeling, Odense Universitetshospital, Svendborg Sygehus, Valdemarsgade 53, 5700 Svendborg.
    Pseudoporphyria is a photosensitive bullous disease, which resembles porphyria cutanea tarda. Normal porphyrin levels in urine, stool and blood define pseudoporphyria. Pseudoporphyria is associated with chronic renal failure, haemodialysis, a variety of drugs (e. Read More

    Photosensitization by imatinib. A photochemical and photobiological study of the drug and its substructures.
    Chem Res Toxicol 2014 Nov 14;27(11):1990-5. Epub 2014 Oct 14.
    Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València , Avda de los Naranjos s/n, 46022 Valencia, Spain.
    Imatinib (IMT) is a promising tyrosine kinase inhibitor used in the treatment of some types of human cancer. It constitutes a successful example of rational drug design based on the optimization of the chemical structure to reach an improved pharmacological activity. Cutaneous reactions, such as increased photosensitivity or pseudoporphyria, are among the most common nonhematological IMT side effects; however, the molecular bases of these clinical observations have not been determined. Read More

    Accelerated photoaging induced by voriconazole treated with Q-switched Nd:YAG laser: case report and review of the literature.
    J Cosmet Laser Ther 2014 Dec 25;16(6):314-6. Epub 2014 Sep 25.
    Department of Dermatology, Clínica Universidad de Navarra , Pamplona , Spain.
    Voriconazole is an antifungal agent mainly used against aspergillosis. Given its wide spectrum of action and limited adverse effects, it has replaced amphotericin B as the drug of choice in the prophylactic treatment of immunocompromised patients. Several adverse effects are caused by this drug with dermatological reactions accounting for 6% of the total. Read More

    Pseudoporphyria following self-medication with chlorophyll.
    Australas J Dermatol 2015 Feb 15;56(1):47-8. Epub 2014 Aug 15.
    Pathwest Laboratory Medicine, QE II Medical Centre, Australia.
    Two cases of pseudoporphyria are described in which the clinical features of porphyria cutanea tarda occurred in the absence of abnormalities in porphyrin metabolism. Both patients presented with skin fragility and bullae on the dorsal aspect of the hands. The patients consumed a commercial liquid chlorophyll drink in which we detected fluorescent compounds with characteristics typical of previously described chlorophyll derived photosensitisers. Read More

    Pseudoporphyria: discussion of etiologic agents.
    J Drugs Dermatol 2014 Aug;13(8):990-2
    Pseudoporphyria describes a photodistributed bullous disorder with negative urinary, fecal, and serum porphyrin studies. Although pseudoporphyria is thought to be extremely rare (less than 100 reported cases4-5), we propose that this entity is underreported. One author (KB) has seen four cases of pseudoporphyria in the past four years. Read More

    Imatinib mesylate-induced pseudoporphyria in two children.
    Pediatr Dermatol 2014 Sep-Oct;31(5):603-7. Epub 2014 Jun 12.
    Department of Paediatric Dermatology, Starship Children's Health, Auckland, New Zealand.
    Imatinib mesylate was the first of several tyrosine kinase inhibitors approved for use in the treatment of a number of human cancers. Adverse cutaneous reactions to imatinib are common. Pseudoporphyria has been infrequently reported in adults undergoing imatinib therapy for chronic myeloid leukemia. Read More

    Pseudoporphyria induced by hemodialysis.
    Postepy Dermatol Alergol 2014 Feb 25;31(1):53-5. Epub 2014 Feb 25.
    Department of Dermatology, Silesian Medical University, Katowice, Poland. Head of Department: Prof. Ligia Brzezińska-Wcisło MD, PhD.
    Pseudoporphyria is a condition identical to porphyria cutanea tarda (PCT) on clinical and histological grounds, but without any biochemical porphyrin abnormality. Excessive sunlight and UVA exposure (for example tanning beds), drugs such as: non-steroidal anti-inflammatory drugs, retinoids, antibiotics, diuretics and others are supposed to be etiological factors of pseudoporphyria. Cases of PCT and pseudoporphyria in patients with HCV infection and hemodialysed due to chronic renal failure were also described. Read More

    Diclofenac-induced pseudoporphyria; an under-recognized condition?
    Clin Exp Dermatol 2014 Apr;39(3):348-50
    Pathology Department, Warwick Hospital, Warwick, UK.
    Pseudoporphyria is a photodistributed bullous disorder that is clinically and histologically similar to porphyria cutanea tarda (PCT), but without abnormal porphyrin biochemistry. Renal failure, dialysis, excessive ultraviolet A and medications, particularly nonsteroidal anti-inflammatory drugs (NSAIDs), have been associated with pseudoporphyria. We report a case of diclofenac-induced pseudoporphyria in a man with psoriatic arthritis. Read More

    Pseudoporphyria associated with nonhemodialyzed renal insufficiency, successfully treated with oral N-acetylcysteine.
    Case Rep Dermatol Med 2013 10;2013:271873. Epub 2013 Apr 10.
    Second Department of Dermatology, "Attikon" General University Hospital, University of Athens, 1 Rimini Street, 124 62 Chaidari, Greece.
    Pseudoporphyria (PP) is a relatively rare, photodistributed bullous dermatosis that resembles porphyria cutanea tarda (PCT), but it is not accompanied by porphyrin abnormalities in the serum, urine, or stool. It was initially described in renal failure patients on dialysis. Thereafter, it has been associated with several aetiological factors. Read More

    Diagnosis of common dermopathies in dialysis patients: a review and update.
    Semin Dial 2012 Jul;25(4):408-18
    Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.
    Cutaneous abnormalities in patients with end-stage renal disease (ESRD) receiving hemodialysis or peritoneal dialysis may demonstrate signs of their underlying condition or reveal associated disease entities. While a thorough examination of the scalp, skin, mucosa, and nails is integral to establishing a diagnosis, certain conditions will resolve only with dialysis or improvement of their renal disease and others may not require or respond to treatment. Half and half nails, pruritus, xerosis, and cutaneous hyperpigmentation are common manifestations in ESRD. Read More

    Cutaneous changes in patients with chronic renal failure on hemodialysis.
    Cutan Ocul Toxicol 2012 Dec 15;31(4):286-91. Epub 2012 Feb 15.
    Department of Dermatology, Yenisehir State Hospital, Kahramanmaras, Turkey.
    Context: A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series.

    Objective: To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the patients. Read More

    Pseudoporphyria induced by dialysis treated with oral N-acetylcysteine.
    An Bras Dermatol 2011 Mar-Apr;86(2):383-5
    Departamento de Dermatologia e Radioterapia, Faculdade de Medicina, Universidade Paulista Julio de Mesquita Filho, Botucatu, SP, Brasil.
    Pseudoporphyria is a rare bullous dermatosis that clinically and histopathologically is similar to porphyria cutanea tarda. It mainly affects patients with chronic renal failure on peritoneal dialysis or hemodialysis. Medications can also be involved in the etiology. Read More

    Hemodialysis-associated pseudoporphyria resistant to N-acetylcysteine.
    Saudi J Kidney Dis Transpl 2011 Mar;22(2):311-4
    Service of Nephrology, Haemodialysis and Kidney Transplantation, Military Hospital, Mohammed V, Rabat, Morocco.
    We report a 33-year-old female patient who had hemodialysis-associated pseudoporphyria which did not respond to treatment with oral N-acetylcysteine. She responded favorably to treatment with the anti-malarial drug, chloroquine. The case is being reported to highlight the difficulty in interpreting the urinary porphyrin assays in patients on hemodialysis. Read More

    Voriconazole-associated phototoxicity.
    Dermatol Online J 2011 Feb 15;17(2):15. Epub 2011 Feb 15.
    Voriconazole is an extended-spectrum triazole antifungal approved for treatment of invasive fungal infections. The drug has been associated with phototoxicity, presenting as photodistributed eruptions such as macular erythema or pseudoporphyria. We describe a 59-year-old man with acute myeloid leukemia, status-post matched unrelated donor stem cell transplant, who developed fungal pneumonia and was placed on posaconazole. Read More

    Melanoma associated with long-term voriconazole therapy: a new manifestation of chronic photosensitivity.
    Arch Dermatol 2010 Mar 18;146(3):300-4. Epub 2010 Jan 18.
    Department of Dermatology, University of California-San Francisco, 1701 Divisadero St., San Francisco, CA 94143, USA.
    Background: Voriconazole is a triazole antifungal agent approved by the US Food and Drug Administration for serious fungal infections, including with Aspergillus, Fusarium, Pseudallescheria, and Scedosporium species. In initial clinical trials, approximately 2% of patients developed cutaneous reactions, including photosensitivity, cheilitis, and xerosis. Subsequent reports have implicated voriconazole as a cause of severe photosensitivity and accelerated photoaging, pseudoporphyria cutanea tarda, and aggressive squamous cell carcinoma. Read More

    [Solarium-induced pseudoporphyria and variegate porphyria as rare differential diagnoses of porphyria cutanea tarda].
    Hautarzt 2009 Oct;60(10):790-3
    Hautklinik des Universitätsklinikums Düsseldorf.
    Three patients presented with typical porphyria cutanea tarda-like vesicles, erosions and scars as well as increased fragility, primarily on the back of the hands. In two of the three, porphyrin workup was normal. Skin biopsy was compatible with porphyria cutanea tarda (PCT) or pseudoporphyria. Read More

    Dermatologic conditions seen in end-stage renal disease.
    Semin Dial 2009 Jan-Feb;22(1):45-55
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.
    The skin changes reported in patients with end-stage renal disease (ESRD) are diverse and manifold. In this article we focus on a collection of specific cutaneous entities seen most frequently in the setting of ESRD, each presenting with distinctive and unique morphology. These include perforating disorders, porphyria cutanea tarda, pseudoporphyria, calcinosis cutis, calciphylaxis, and nephrogenic systemic fibrosis. Read More

    Imatinib-induced pseudoporphyria.
    Clin Exp Dermatol 2009 Aug 9;34(6):705-7. Epub 2008 Dec 9.
    Departments of Dermatology, Meander Medical Center, Amersfoort, The Netherlands.
    Imatinib, a synthetic tyrosine kinase inhibitor, is used as first-line therapy for chronic myeloid leukaemia. Imatinib treatment is associated with a variety of adverse effects, most of which are mild to moderate and generally abate after the first months of treatment. Cutaneous adverse reactions are often encountered in patients using imatinib. Read More

    Pseudoporphyria associated with voriconazole.
    J Drugs Dermatol 2007 Oct;6(10):1042-4
    Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA.
    Pseudoporphyria is a rare photosensitivity that resembles porphyria cutanea tarda clinically but lacks the biochemical derangements in porphyrin metabolism. The majority of cases are induced by ingestion of particular medications. We report a case of pseudoporphyria induced by voriconazole, a second-generation triazole antifungal agent, in a lung transplant recipient. Read More

    Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus.
    Lupus 2007 ;16(9):741-5
    Department of Dermatology, Hospital Juan Canalejo, Xubias de Arriba 84, 15006 La Coruña, Spain.
    The term "Acute Syndrome of Apoptotic Pan-Epidermolysis" (ASAP) designs clinical entities characterized by massive cleavage of the epidermis resulting from hyperacute epidermal basal cell apoptotic injury. It can be seen typically in classic toxic epidermal necrolysis (TEN), but occasionally occurs in non-drug-induced entities called "TEN-like" diseases (e.g. Read More

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