153 results match your criteria Pseudopapilledema


Utility of Ultrasound and Optical Coherence Tomography in Differentiating Between Papilledema and Pseudopapilledema in Children.

J Neuroophthalmol 2021 Apr 14. Epub 2021 Apr 14.

Division of Ophthalmology (MKF), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and Departments of Neurology (GTL, RAA), and Ophthalmology (MKF, G-SY, RAA), The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Differentiating between papilledema and pseudopapilledema in children presenting with mild-to-moderate optic nerve head elevation is challenging. This study sought to determine which B-scan ultrasonography (BSUS) and optical coherence tomography (OCT) features, individually or in combination, are best able to differentiate between papilledema and pseudopapilledema in children.

Methods: Children presenting with optic nerve head elevation of unknown etiology were eligible if they underwent BSUS and OCT performed by the same investigator. Read More

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The role of optical coherence tomography in the diagnosis of afferent visual pathway problems: A neuroophthalmic perspective.

Handb Clin Neurol 2021 ;178:97-113

Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, MN, United States.

Optical coherence tomography (OCT) is a noninvasive ocular imaging technique that has become a standard tool in neuroophthalmic practice. Specifically, OCT captures retinal manifestations of neuroaxonal injury caused by lesions along anterior and posterior regions of the afferent visual pathway, in patients presenting with vision loss. More recently, the advent of OCT angiography (OCTA) has enabled evaluation of the choroidal and retinal microvasculature, thus informing our understanding regarding vascular mechanisms associated with optic nerve and retinal injuries. Read More

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January 2021

Childhood-Onset Leber Hereditary Optic Neuropathy: Particular Features.

Int Med Case Rep J 2021 12;14:163-169. Epub 2021 Mar 12.

Department of Ophthalmology, Centro Hospitalar Universitário de São João, Porto, Portugal.

Background: Leber hereditary optic neuropathy (LHON) is an optic neuropathy of mitochondrial inheritance. Childhood-onset disease is relatively rare and there are limited data on this important patient subgroup.

Case Presentation: We present 3 particular presentations of LHON. Read More

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Pseudopapilledema in Cockayne syndrome.

Am J Ophthalmol Case Rep 2021 Jun 18;22:101035. Epub 2021 Feb 18.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Purpose: This report describes pseudopapilledema in two siblings with Cockayne syndrome and examines a structural mechanism for its development.

Observations: Two siblings with genetically documented Cockayne syndrome, enophthalmos, and hyperopia were found to have pseudopapilledema. Magnetic resonance (MR) imaging disclosed retrodisplacement of the globes, axial foreshortening, posterior scleral flattening, and protrusion of the optic papilla into the vitreous. Read More

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The sensitivity and specificity of retinal and choroidal folds to distinguish between mild papilloedema and pseudopapilledema.

Eye (Lond) 2021 Jan 19. Epub 2021 Jan 19.

Department of Neuro-ophthalmology, Departments of Ophthalmology and Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Purpose: To determine if the presence or absence of retinal and choroidal folds on SD-OCT imaging can distinguish between mild papilloedema and pseudopapilledema.

Design: Cross-sectional cohort study METHODS: Subjects with optic disc elevation (Frisen grades 1 and 2 only) were eligible to be enrolled prospectively. Pseudopapilledema was defined as a lack of change in optic disc appearance between two visits <6 months apart, and papilloedema was defined as change in optic disc appearance between two visits <6 months apart determined by review of fundus photographs by a masked neuro-ophthalmologist. Read More

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January 2021

Etiology of Optic Disc Swelling in a Tertiary Care Center in Nigeria.

Niger J Clin Pract 2020 Dec;23(12):1690-1694

Department of Ophthalmology, University of Benin, Benin City, Edo State, Nigeria.

Background: Optic disc swelling in clinical practice is worrisome. It may be associated with benign, sight- or life-threatening conditions. The common etiologies of optic disc swelling are variable in different communities. Read More

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December 2020

Role of Ocular Ultrasonography to Distinguish Papilledema From Pseudopapilledema.

J Neuroophthalmol 2020 Jun 19. Epub 2020 Jun 19.

Department of Ophthalmology and Visual Science (AAK), Yale University School of Medicine, New Haven, Connecticut; Department of Ophthalmology (MP), Center for Preventative Ophthalmology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Ophthalmology (CA), Icahn School of Medicine at Mount Sinai, New York, New York; Scheie Eye Institute (AGR, GTL, KSS, MAT), Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Ophthalmology (IJ), University of Alberta, Edmonton, Canada; Department of Medicine (SB), Temple University, Philadelphia, Pennsylvania; Rutgers Robert Wood Johnson Medical School (JC), Piscataway, New Jersey; Boston University Henry M. Goldman School of Dental Medicine (DM), Boston, Massachusetts; and Department of Neurology (GTL), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: We prospectively evaluated the sensitivity and specificity of ocular ultrasonography (OUS) to distinguish papilledema from pseudopapilledema.

Methods: Forty-nine study participants, with optic disc elevation, underwent neuro-ophthalmic evaluation, OUS, fundus photography, and optical coherence tomography (OCT) of the optic nerve head at the initial and follow-up visits (≤6 months apart). Participants were classified as having papilledema if there was a change in optic nerve appearance on fundus photographs, as determined by a masked observer, between initial and follow-up visits ≤6 months apart. Read More

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Teaching Neuroimages: Distinguishing Papilledema from Pseudopapilledema using Optical Coherence Tomography.

Neurology 2020 Dec 8. Epub 2020 Dec 8.

From the Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, United Kingdom.

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December 2020

Variability Within Optic Nerve Optical Coherence Tomography Measurements Distinguishes Papilledema From Pseudopapilledema.

J Neuroophthalmol 2020 Oct 28. Epub 2020 Oct 28.

Department of Ophthalmology and Visual Sciences (AMF, RAL, QC, SPD), Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Biostatistics (YL, QC), Vanderbilt University Medical Center, Nashville, Tennessee.

Background: To report a linear risk score obtained using clock-hour optical coherence tomography (OCT) data from papilledema and pseudopapilledema nerves that differentiates between the 2 diagnoses with high sensitivity and specificity.

Methods: Patients presenting to a single neuro-ophthalmologist with papilledema or pseudopapilledema were included for a retrospective review. The absolute consecutive difference in OCT retinal nerve fiber layer (RNFL) thickness between adjacent clock hours and the mean magnitude of thickness for clock hours 1-12 were compared between the 2 groups using mixed-effect models adjusting for age and clock hour with a random intercept for subjects and eyes (nested within subject). Read More

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October 2020

Intracranial Hypertension and Papilledema in a Large Cohort of Pediatric Patients With Alagille Syndrome.

J Pediatr Gastroenterol Nutr 2020 11;71(5):655-662

Pediatric Gastroenterology and Hepatology Department, Cliniques Universitaires St-Luc, Bruxelles, Belgium.

Aims And Background: Ophthalmic abnormalities are amongst the 5 major criteria required for a diagnosis of Alagille syndrome (ALGS), of which embryotoxon, pseudopapilledema, and hypopigmented retinopathy are the most common. Papilledema with or without intracranial hypertension (ICHT) is rarely described. We report 9 pediatric cases of ALGS with bilateral papilledema, 5 of which were diagnosed with ICHT. Read More

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November 2020

Utility of Spectral-Domain Optical Coherence Tomography in Differentiating Papilledema From Pseudopapilledema: A Prospective Longitudinal Study.

J Neuroophthalmol 2020 Sep 11. Epub 2020 Sep 11.

Department Ophthalmology (IJ), University of Alberta, Edmonton, Canada; Perelman School of Medicine at the University of Pennsylvania (CA), Philadelphia, Pennsylvania; Center for Preventative Ophthalmology and Biostatistics at the University of Pennsylvania (MP), Philadelphia, Pennsylvania; Department of Ophthalmology and Visual Science (AAK), Yale School of Medicine, New Haven, Connecticut; Division of Neuro-ophthalmology (GTL, KSS, RAA, AR, MAT), Departments of Ophthalmology and Neurology, Scheie Eye Institute at the University of Pennsylvania, Philadelphia, Pennsylvania; Center for the Prevention and Treatment of Visual Loss (MKG, J-KW), VA Health Care System, Iowa City, Iowa; and Department of Electrical and Computer Engineering (MKG, J-KW), the University of Iowa, Iowa City, Iowa.

Background: Prospective and longitudinal studies assessing the utility of spectral-domain optical coherence tomography (SD-OCT) to differentiate papilledema from pseudopapilledema are lacking. We studied the sensitivity and specificity of baseline and longitudinal changes in SD-OCT parameters with 3D segmentation software to distinguish between papilledema and pseudopapilledema in a cohort of patients referred for evaluation of undiagnosed optic disc elevation.

Methods: Fifty-two adult patients with optic disc elevation were enrolled in a prospective longitudinal study. Read More

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September 2020

Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema.

J Neuroophthalmol 2021 Mar;41(1):77-92

Department Ophthalmology (PAS), State University of New York at Stony Brook, Stony Brook, New York; Departments of Neurology, Ophthalmology, Neurosurgery (MJK), Icahn School of Medicine at Mount Sinai and New York Eye and Ear Infirmary, New York, New York; Department of Ophthalmology and Visual Sciences (RHK), the University of Iowa, Iowa City, Iowa; and Center for the Prevention and Treatment of Visual Loss (RHK), Iowa City VA Health Care System, Iowa City, Iowa.

Background: Distinguishing optic disc edema from pseudopapilledema is a common, sometimes challenging clinical problem. Advances in spectral-domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) has proven to be a cost effective, noninvasive, outpatient procedure that may help. At its core are tools that quantify the thickness of the retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL). Read More

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The role of clinical signs in the diagnosis of papilledema: development of an algorithm.

Childs Nerv Syst 2021 Feb 24;37(2):599-605. Epub 2020 Aug 24.

Department of Pediatrics, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.

Purpose: The aim of this study was not only to emphasize the role of clinical signs as well as ophthalmologic evaluation for accurate and differential diagnosis of papilledema (PE), but also to present an instructive algorithm that would help to eliminate unnecessary examinations and treatments.

Method: The files of 43 patients (ages 0-18) diagnosed with PE were retrospectively reviewed. The study included 25 patients from our pediatric neurology outpatient clinic, who were thought to have PE, and 18 patients, who were referred from the external centers to our hospital with a pre-diagnosis of PE. Read More

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February 2021

Update in Pediatric Pseudotumor Cerebri Syndrome.

Authors:
Shannon J Beres

Semin Neurol 2020 Jun 18;40(3):286-293. Epub 2020 May 18.

Department of Neurology and Ophthalmology, Stanford University, Palo Alto, California.

Pseudotumor cerebri syndrome (PTCS) is a rare condition in children presenting with headache and papilledema from increased intracranial pressure that can cause significant morbidity. This can be idiopathic, also known as idiopathic intracranial hypertension or primary intracranial hypertension, or can be secondary to medications and associated medical conditions. Given the threat to vision, early detection and treatment is needed in all age groups. Read More

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Imaging Methods for Differentiating Pediatric Papilledema from Pseudopapilledema: A Report by the American Academy of Ophthalmology.

Ophthalmology 2020 10 5;127(10):1416-1423. Epub 2020 May 5.

Stein Eye Institute, University of California, Los Angeles, California.

Purpose: To review the published literature on the accuracy of ophthalmic imaging methods to differentiate between papilledema and pseudopapilledema in children.

Methods: Literature searches were conducted in January 2020 in the PubMed database for English-language studies with no date restrictions and in the Cochrane Library database without any restrictions. The combined searches yielded 354 abstracts, of which 17 were reviewed in full text. Read More

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October 2020

Coexistence of papilledema and pseudopapilledema after remission of idiopathic intracranial hypertension by bariatric surgery.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):157-159

Instituto de Olhos, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil.

A 37-year-old woman complained of headaches following bilateral visual loss in the past two years. She was obese and had undergone bariatric surgery three months earlier, followed by a considerable weight loss. Neuro-ophthalmic examination revealed a bilateral swollen optic disk. Read More

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Microvascular Changes Associated with Optic Disc Drusen: Case Report

Turk J Ophthalmol 2019 Oct;49(5):300-304

Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey

Optic disc drusen (ODD) is an important clinical entity that is sometimes misdiagnosed as papilledema because of elevated and blurred disc margins. A 17-year-old male who presented with headaches underwent detailed ophthalmological examination as well as colored fundus photography, B-scan ultrasonography (USG), fundus autofluorescence (FAF), optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), and visual field testing. His visual acuity was 10/10 in both eyes. Read More

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October 2019

[What's New in Papilloedema, Pseudotumor Cerebri and Idiopathic Intracranial Hypertension].

Authors:
Julia Biermann

Klin Monbl Augenheilkd 2019 Nov 10;236(11):1304-1311. Epub 2019 Oct 10.

Klinik für Augenheilkunde, Universitätsklinikum Münster, Münster.

Several conditions share a cardinal feature on funduscopic examination: bilateral blurred optic disc margins. Pseudopapilledema (e.g. Read More

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November 2019

Accuracy of machine learning for differentiation between optic neuropathies and pseudopapilledema.

BMC Ophthalmol 2019 Aug 9;19(1):178. Epub 2019 Aug 9.

Department of Ophthalmology, Kim's Eye Hospital, Youngshin-ro 136, Youngdeungpo-gu, Seoul, 150-034, South Korea.

Background: This study is to evaluate the accuracy of machine learning for differentiation between optic neuropathies, pseudopapilledema (PPE) and normals.

Methods: Two hundred and ninety-five images of optic neuropathies, 295 images of PPE, and 779 control images were used. Pseudopapilledema was defined as follows: cases with elevated optic nerve head and blurred disc margin, with normal visual acuity (> 0. Read More

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Role of ultrasonographic optic nerve sheath diameter in the diagnosis and follow-up of papilledema and its correlation with Frisén's severity grading.

Indian J Ophthalmol 2019 08;67(8):1310-1313

Department of Ophthalmology, St John's Medical College, Bangalore, Karnataka, India.

Purpose: The aim of this study was to compare the ultrasonographic optic nerve sheath diameter (ONSD) in different grades of papilledema and in controls and to evaluate ONSD in atrophic papilledema/optic atrophy when raised ICP was suspected.

Methods: Prospective cross-sectional case-control study. Following an ocular examination, papilledema was graded clinically using modified Frisén's grading. Read More

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Don't Miss This! Red Flags in the Pediatric Eye Exam: Blurred Disc Margins.

Authors:
Hilda Capo

J Binocul Vis Ocul Motil 2019 Jul-Sep;69(3):110-115

a Bascom Palmer Eye Institute, University of Miami Miller School of Medicine , Miami , Florida.

Evaluating a patient with blurred optic disc margins, particularly a child, and establishing a diagnosis can be a demanding task. We aim to review the differential diagnosis of blurred disc margins, identify the clinical characteristics of a swollen optic disc, discuss imaging modalities used in the evaluation of the optic nerve head as tools for formulating a diagnosis, and identify red flags that may indicate a serious disorder. Read More

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January 2020

Custom Optical Coherence Tomography Parameters for Distinguishing Papilledema from Pseudopapilledema.

Optom Vis Sci 2019 08;96(8):599-608

College of Optometry, University of Houston, Houston, Texas.

Significance: Causes of papilledema can be life-threatening; however, distinguishing papilledema from pseudopapilledema is often challenging. The conventional optical coherence tomography (OCT) scan for assessing the optic nerve often fails to detect mild papilledema. Our study suggests that parameters derived from volumetric OCT scans can provide additional useful information for detecting papilledema. Read More

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Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes.

Acta Ophthalmol 2020 Mar 1;98(2):195-200. Epub 2019 Jul 1.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.

Purpose: Optic disc drusen (ODD) are calcified optic nerve head deposits. Objectives of this study were to examine the prevalence of ODD in eyes removed by enucleation and to describe related histopathological signatures of ODD and surrounding tissues.

Methods: The study was a retrospective observational case series study assessing and re-evaluating enucleated eyes in Denmark from 1980 to 2015 by microscopy. Read More

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Ultrasound-Assisted Diagnosis of Optic Neuritis in the Emergency Department: A Case Report.

J Emerg Med 2019 Aug 25;57(2):212-215. Epub 2019 Jun 25.

Department of Emergency Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Background: Optic neuritis is a common cause of subacute unilateral vision loss, occurring in 1-5 per 100,000 persons per year. It is more common in Caucasians, women, and those from countries with northern latitudes. Those aged 20-49 years are at greatest risk. Read More

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Important functional distress in a teenager with optic nerve drusen.

Rom J Ophthalmol 2019 Jan-Mar;63(1):75-85

"Prof. Dr. Agrippa Ionescu" Clinical Emergency Hospital, Bucharest, Romania.

We present a case of bilateral optic disc drusen and severe visual field loss in a female patient diagnosed at a very young age. Read More

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Diagnosis and Imaging of Optic Nerve Head Drusen.

Semin Ophthalmol 2019 3;34(4):256-263. Epub 2019 Jun 3.

a Department of Ophthalmology, Massachusetts Eye and Ear Infirmary , Harvard Medical School , Boston , MA , USA.

The presence of optic nerve swelling in pediatric patients is a frequent cause for referral to pediatric ophthalmologists and neuro-ophthalmologists because this finding can be the harbinger of serious neurologic disease including brain tumor, demyelinating disease, infiltrative disease of the optic nerve, or idiopathic intracranial hypertension. Optic nerve head drusen (ONHD) are common and can be particularly difficult to distinguish from true optic nerve swelling in pediatric patients because the ONHD are typically buried beneath the substance of the optic nerve. Correct identification of ONHD is relevant because of the visual morbidity associated with this condition and because of the need to distinguish pseudopapilledema secondary to ONHD from true optic nerve swelling. Read More

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Usefulness of Standardized A-Scan technique in distinguishing papilledema from pseudopapilledema.

Childs Nerv Syst 2019 09 1;35(9):1445-1446. Epub 2019 Jun 1.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Via Salvador Allende, Baronissi, 84081, Salerno, Italy.

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September 2019

A child with unilateral disk elevation.

Surv Ophthalmol 2021 Mar-Apr;66(2):402-406. Epub 2019 May 28.

Department of Ophthalmology, Dean McGee Eye Institute/University of Oklahoma, Oklahoma City, Oklahoma, USA.

A healthy 7-year-old girl underwent a routine eye examination and was referred for unilateral, left optic nerve swelling. Best-corrected visual acuity in the affected eye was 20/20 with full Ishihara color plates and no relative afferent pupillary defect. Initial extensive workup was normal for any cause of unilateral disk swelling. Read More

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Papilledema or pseudopapilledema?

Indian J Ophthalmol 2019 04;67(4):449

Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, 14th Floor, Philadelphia, PA 19107, USA.

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