120 results match your criteria Pseudopapilledema


Intracranial hypertension: a current review.

Curr Opin Pediatr 2018 Dec;30(6):764-774

Department of Neurology, Nationwide Children's Hospital, Columbus, Ohio, USA.

Purpose Of Review: To provide a current review of recent publications with regards to intracranial hypertension.

Recent Findings: Attempts were made to provide pediatric data; however, the recent completion of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) has provided a wealth of data with regards to adult intracranial hypertension.The pediatric incidence of intracranial hypertension ranges between 0. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000689DOI Listing
December 2018
9 Reads

Re: Chang et al.: Accuracy of diagnostic imaging modalities for classifying pediatric eyes as papilledema versus pseudopapilledema (Ophthalmology. 2017;124:1839-1848).

Ophthalmology 2018 Sep 21;125(9):e62. Epub 2018 Aug 21.

Columbia University Medical Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2018.03.035DOI Listing
September 2018
9 Reads

Chiari 1 malformation with optic disc drusen.

Neuroophthalmology 2018 Aug 9;42(4):256-260. Epub 2018 Jan 9.

Atatürk Training and Research Hospital, Department of Ophthalmology, Yildirim Beyazit University, Ankara, Turkey.

A 32 year old female patient with CM 1 diagnosis was referred for the management of papilledema. Ophthalmologic examination revealed normal visual acuity (20/20 in both eyes), normal optic nerve function tests and normal slit-lamp biomicroscopic findings. Fundoscopy revealed bilateral irregular optic nerve heads with blurred margins. Read More

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https://www.tandfonline.com/doi/full/10.1080/01658107.2017.1
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http://dx.doi.org/10.1080/01658107.2017.1400571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056221PMC
August 2018
14 Reads

Peripapillary Ovoid Hyperreflectivity in Optic Disc Edema and Pseudopapilledema.

Ophthalmology 2018 Oct 8;125(10):1662-1664. Epub 2018 Jun 8.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2018.04.036DOI Listing
October 2018
8 Reads

Comparison of Ocular Ultrasonography and Magnetic Resonance Imaging for Detection of Increased Intracranial Pressure.

Front Neurol 2018 24;9:278. Epub 2018 Apr 24.

Department of Ophthalmology, Mayo Clinic, Rochester, NY, United States.

Background/aims: To evaluate and compare the performance of ocular ultrasonography (US) and magnetic resonance imaging (MRI) for detecting increased intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH).

Methods: Twenty-two patients with papilledema from IIH and 22 with pseudopapilledema were prospectively recruited based on funduscopic and clinical findings. Measurements of optic nerve sheath diameters (ONSDs) 3 mm behind the inner sclera were performed on B-scan US and axial T2-weighted MRI examinations. Read More

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http://dx.doi.org/10.3389/fneur.2018.00278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928295PMC
April 2018
9 Reads

Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema.

J AAPOS 2018 Jun 10;22(3):247. Epub 2018 Mar 10.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.jaapos.2018.02.001DOI Listing
June 2018
11 Reads

Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema.

J AAPOS 2018 Jun 10;22(3):247-248. Epub 2018 Mar 10.

Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

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http://dx.doi.org/10.1016/j.jaapos.2018.03.001DOI Listing
June 2018
4 Reads

Optic Nerve Head and Macular Optical Coherence Tomography Measurements in Papilledema Compared With Pseudopapilledema.

J Neuroophthalmol 2018 Feb 22. Epub 2018 Feb 22.

Eye Research Center (MAF, SO, SM), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; Department of Ophthalmology (SM), University of California, San Francisco, San Francisco, California; and Department of Ophthalmology (PSS), University of Colorado School of Medicine, Aurora, Colorado.

Background: To compare macular and optic nerve head optical coherence tomography (OCT) measurements in mild to moderate papilledema and pseudopapilledema.

Methods: One hundred nineteen eyes of 61 patients with mild to moderate papilledema, 84 eyes of 48 patients with pseudopapilledema, and 60 eyes of 60 healthy normal individuals were enrolled in this cross-sectional study. Using Spectralis SD-OCT, macular scans with macular ganglion cell-inner plexiform layer (GCIPL) and macular retinal nerve fiber layer (RNFL) segmentation were performed and divided into 2 regions (inner and outer, with a diameter of 3 and 6 mm, respectively); in addition, Bruch membrane opening (BMO) area and peripapillary RNFL thickness were obtained. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000641DOI Listing
February 2018
4 Reads

Re: Chang et al.: Accuracy of diagnostic imaging modalities for classifying pediatric eyes as papilledema versus pseudopapilledema (Ophthalmology. 2017;124:1839-1848).

Ophthalmology 2018 03;125(3):e23

Department of Ophthalmology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

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http://dx.doi.org/10.1016/j.ophtha.2017.09.025DOI Listing
March 2018
2 Reads

Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema.

J AAPOS 2018 Feb 1;22(1):38-43.e3. Epub 2017 Dec 1.

Department of Ophthalmology, Duke Eye Center and Duke University Medical Center, Durham, North Carolina. Electronic address:

Purpose: To determine whether the diameter of Bruch's membrane opening (BMO) can distinguish mild papilledema from pseudopapilledema using optical coherence tomography (OCT).

Methods: The medical records of pediatric patients with pseudopapilledma due to optic nerve head (ONH) drusen, patients with papilledema, and normal control subjects were retrospectively reviewed. All eyes underwent OCT imaging of the BMO and retinal nerve fiber layer (RNFL). Read More

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http://dx.doi.org/10.1016/j.jaapos.2017.09.003DOI Listing
February 2018
4 Reads

Use of A-scan Ultrasound and Optical Coherence Tomography to Differentiate Papilledema From Pseudopapilledema.

Optom Vis Sci 2017 12;94(12):1081-1089

College of Optometry, University of Houston, Houston, Texas.

Significance: Differentiating papilledema from pseudopapilledema reflecting tilted/crowded optic discs or disc drusen is critical but can be challenging. Our study suggests that spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness and retrobulbar optic nerve sheath diameter (ONSD) measured by A-scan ultrasound provide useful information when differentiating the two conditions.

Purpose: To evaluate the use of A-scan ultrasound and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT) in differentiating papilledema associated with idiopathic intracranial hypertension from pseudopapilledema. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726530PMC
December 2017
4 Reads

The diagnostic challenge of evaluating papilledema in the pediatric patient.

Taiwan J Ophthalmol 2017 Jan-Mar;7(1):15-21

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.

Pseudopapilledema is a fairly common finding in ophthalmic practice, and in many cases, the diagnosis is straightforward. However, an accurate diagnosis can challenge the most seasoned clinicians, and missing true papilledema can result in life-threatening or vision-threatening consequences. In this review, we describe the clinical findings and a diagnostic algorithm to distinguish pseudopapilledema and papilledema in the pediatric patients. Read More

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http://dx.doi.org/10.4103/tjo.tjo_17_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525598PMC
October 2017
8 Reads

Optical Coherence Tomography to Differentiate Papilledema from Pseudopapilledema.

Curr Neurol Neurosci Rep 2017 Aug 17;17(10):74. Epub 2017 Aug 17.

Department of Ophthalmology, Hospital Universitario Ramón y Cajal (IRYCIS), Carretera de Colmenar Viejo Km 9.100, 28034, Madrid, Spain.

Purpose Of Review: Mild papilledema may be difficult to distinguish by clinical observation from pseudopapilledema. An accurate diagnosis is critical to avoid invasive workup and unwarranted treatment. In this review, we focus on the development and subsequent role of optical coherence tomography (OCT) in detecting and differentiating optic nerve head drusen (ONHD) from papilledema and other causes of acquired swelling of the optic disc. Read More

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http://link.springer.com/10.1007/s11910-017-0790-6
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http://dx.doi.org/10.1007/s11910-017-0790-6DOI Listing
August 2017
11 Reads

Pediatric Pseudotumor Cerebri Syndrome.

J Neuroophthalmol 2017 09;37 Suppl 1:S33-S40

Department of Ophthalmology (PHP), Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Jones Eye Institute, Little Rock, Arkansas; and Department of Ophthalmology and Visual Sciences (CAS), University of British Columbia, Vancouver, British Columbia, Canada.

Idiopathic intracranial hypertension, otherwise known as primary pseudotumor cerebri syndrome (PTCS), most frequently occurs in obese women of childbearing age. However, children may be affected as well. This review will address recent findings regarding demographics, diagnosis, and treatment of pediatric PTCS. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000548DOI Listing
September 2017
2 Reads

Accuracy of Diagnostic Imaging Modalities for Classifying Pediatric Eyes as Papilledema Versus Pseudopapilledema.

Ophthalmology 2017 12 18;124(12):1839-1848. Epub 2017 Jul 18.

Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California; Stein Eye Institute, University of California, Los Angeles, Los Angeles, California. Electronic address:

Purpose: To identify the most accurate diagnostic imaging modality for classifying pediatric eyes as papilledema (PE) or pseudopapilledema (PPE).

Design: Prospective observational study.

Subjects: Nineteen children between the ages of 5 and 18 years were recruited. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.06.016DOI Listing
December 2017
13 Reads

Detecting optic nerve head swelling on ultrasound and optical coherence tomography in children and young people: an observational study.

Br J Ophthalmol 2018 03 21;102(3):318-322. Epub 2017 Jun 21.

NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.

Background: Following high-profile cases, referrals for evaluation of 'suspicious optic discs' to eye clinics in the UK have sharply increased, asking ophthalmologists to reliably distinguish between true and pseudopapilloedema. Optic nerve sheath dilatation (ONSD) on ocular ultrasound (US) is considered a reliable sign of true papilloedema, but this test is not widely available. Recently, anterior bowing of Bruch's membrane (BM) and increased retinal nerve fibre layer thickness on optical coherence tomography (OCT) have emerged as indicators of intracranial hypertension, and OCT is widely available. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2017-310196DOI Listing
March 2018
11 Reads

The efficacy of orbital ultrasonography and magnetic resonance imaging findings with direct measurement of intracranial pressure in distinguishing papilledema from pseudopapilledema.

Childs Nerv Syst 2017 Sep 22;33(9):1501-1507. Epub 2017 May 22.

Faculty of Medicine, Department of Ophthalmology, Gazi University, Ankara, Turkey.

Introduction: The goal of this study was to evaluate the utility of orbital ultrasonography and magnetic resonance imaging in the diagnosis of idiopathic intracranial hypertension (IIH).

Method: We reviewed the medical records of patients referred to our department for suspected IIH.

Results: Seven children were diagnosed with IIH. Read More

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http://dx.doi.org/10.1007/s00381-017-3454-6DOI Listing
September 2017
30 Reads

Use of MultiColor imaging in the assessment of suspected papilledema in 20 consecutive children.

J AAPOS 2016 12 2;20(6):532-536. Epub 2016 Nov 2.

University Hospital Southampton NHS Foundation Trust, United Kingdom.

Purpose: To investigate the use of MultiColor Scanning Laser Imaging as an adjunct to traditional imaging modalities in the assessment of children with suspected disk swelling.

Methods: In this study of 20 consecutive children with suspected papilledema, MultiColor imaging was performed on all patients in addition to fundus examination, fundus autofluorescence, disk spectral domain optical coherence tomography (SD-OCT), and disk retinal nerve fiber layer thickness (RNFL) measurement. Diagnoses were determined in all 20 patients, and all images were evaluated by a medical retina specialist. Read More

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http://dx.doi.org/10.1016/j.jaapos.2016.08.012DOI Listing
December 2016
7 Reads

Optic disk drusen in children.

Surv Ophthalmol 2016 Nov - Dec;61(6):745-758. Epub 2016 Mar 29.

Department of Ophthalmology, Stein Eye Institute, Los Angeles, California, USA; University of California, Stein Eye Institute, Los Angeles, California, USA. Electronic address:

Optic disk drusen occur in 0.4% of children and consist of acellular intracellular and extracellular deposits that often become calcified over time. They are typically buried early in life and generally become superficial, and therefore visible, later in childhood, at the average age of 12 years. Read More

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http://dx.doi.org/10.1016/j.survophthal.2016.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042815PMC
May 2017
3 Reads

[Optic disc swelling : A compilation of relevant differential diagnoses].

Ophthalmologe 2016 Nov;113(11):967-981

Augenklinik der Universitätsmedizin, Johannes Gutenberg Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

Optic disc oedema describes blurred optic disc margins. It describes an unspecific clinical sign with various possible underlying causal mechanisms. The correct diagnosis and the detection of the underlying disease is however of special clinical importance. Read More

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http://dx.doi.org/10.1007/s00347-016-0353-2DOI Listing
November 2016
4 Reads

Surgical and molecular pathology of pancreatic neoplasms.

Diagn Pathol 2016 Jun 7;11(1):47. Epub 2016 Jun 7.

Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Background: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance.

Main Body: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. Read More

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http://dx.doi.org/10.1186/s13000-016-0497-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897815PMC
June 2016
6 Reads

Peripapillary Retinal Nerve Fiber Layer Thickness Corresponds to Drusen Location and Extent of Visual Field Defects in Superficial and Buried Optic Disc Drusen.

J Neuroophthalmol 2016 Mar;36(1):41-5

Department of Ophthalmology, Glostrup Hospital, Denmark.

Background: Optic disc drusen (ODD) are hyaline deposits located within the optic nerve head. Peripapillary retinal nerve fiber layer (RNFL) thinning is associated with the high prevalence of visual field defects seen in ODD patients. The goal of this study was to investigate the characteristics of patients with ODD and to compare the peripapillary RNFL thickness to the extent of visual field defects and anatomic location (superficial or buried) of ODD. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000325DOI Listing
March 2016
11 Reads

Optical Coherence Tomography for the Neurologist.

Semin Neurol 2015 Oct 6;35(5):564-77. Epub 2015 Oct 6.

Departments of Neurology, New York University School of Medicine, New York, New York.

Optical coherence tomography (OCT) is a relatively new technology that is now routinely and very widely used by ophthalmologists for structural documentation of the optic nerve and retina. In neuro-ophthalmology and neurology, the value of OCT is ever expanding; its role in an increasing number of conditions is being reported in parallel with the advances of the technology. Currently, as a clinical tool, OCT is particularly useful for the structural measurement of peripapillary retinal nerve fiber layer thickness, optic nerve head volumetric analysis, and macular anatomy. Read More

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http://dx.doi.org/10.1055/s-0035-1563579DOI Listing
October 2015
5 Reads

A new case of de novo 6q24.2-q25.2 deletion on paternal chromosome 6 with growth hormone deficiency: a twelve-year follow-up and literature review.

BMC Med Genet 2015 Aug 23;16:69. Epub 2015 Aug 23.

Genetics and Molecular Medicine Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Background: Deletions on the distal portion of the long arm of chromosome 6 are relatively uncommon, and only a small number occurs in the paternal copy, causing growth abnormalities. As a result, extensive clinical descriptions are lacking.

Case Presentation: We describe a male of Italian descent born at 35 weeks by elective caesarean delivery presenting hypoplastic left colon, bilateral inguinal hernia, dysplastic tricuspid and pulmonary valves, premature ventricular contractions, recurrent otitis media, poor feeding, gastro-oesophageal reflux, bilateral pseudopapilledema, and astigmatism. Read More

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http://dx.doi.org/10.1186/s12881-015-0212-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593197PMC
August 2015
4 Reads

Anatomic and visual function outcomes in paediatric idiopathic intracranial hypertension.

Br J Ophthalmol 2016 Apr 12;100(4):505-9. Epub 2015 Aug 12.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina USA.

Background: There is a paucity of literature describing risk factors for vision loss in paediatric idiopathic intracranial hypertension (IIH). We investigate the final visual function, spectral domain optical coherence tomography (SD-OCT) and enhanced depth imaging (EDI)-OCT findings in children with papilledema caused by IIH.

Methods: Medical records of 31 patients with paediatric IIH (age ≤17 years) were retrospectively reviewed. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2015-307043DOI Listing
April 2016
5 Reads

Outcome of pediatric patients referred for papilledema.

J AAPOS 2015 Aug 30;19(4):344-8. Epub 2015 Jul 30.

Eugene and Marilyn Glick Eye Institute, Indiana University Medical Center, Indianapolis, Indiana. Electronic address:

Purpose: To determine the prevalence of papilledema versus pseudopapilledema among children referred for suspected papilledema and to identify clinical factors differentiating the two diagnoses.

Methods: This is a prospective, cross-sectional analysis of patients <18 years old referred to a pediatric ophthalmology clinic for suspected papilledema by ophthalmoscopic examination between April 2012 and February 2014. Patients underwent detailed ophthalmologic and, when indicated, neurologic evaluation to determine the presence or absence of papilledema. Read More

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http://dx.doi.org/10.1016/j.jaapos.2015.05.007DOI Listing
August 2015
3 Reads

SD-OCT to distinguish papilledema from pseudopapilledema.

Arch Soc Esp Oftalmol 2015 Oct 3;90(10):481-3. Epub 2015 Jul 3.

Servicio de Oftalmología, Hospital Clínico Universitario, Valladolid, España.

Cases Report: Two patients presented with headache and bilateral papillary edema. Patient 1 was found to have a papilledema (P) with intracranial pressure of 32cmH2O. Patient 2 was found to have a migraine with a pseudopapilledema (PP) (optic nerve head drusen). Read More

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http://dx.doi.org/10.1016/j.oftal.2015.05.001DOI Listing
October 2015
2 Reads

Optic nerve sonography in the diagnostic evaluation of pseudopapilledema and raised intracranial pressure: a cross-sectional study.

Neurol Res Int 2015 22;2015:146059. Epub 2015 Mar 22.

Iran University of Medical Sciences, Tehran 1449614535, Iran.

Introduction. Differentiating pseudopapilledema from papilledema which is optic disk edema and a result of increased ICP (intracranial pressure) is important and can be done with noninvasive methods like orbital ultrasound examination. Method. Read More

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http://dx.doi.org/10.1155/2015/146059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385686PMC
April 2015
3 Reads

Optical coherence tomography in papilledema and pseudopapilledema with and without optic nerve head drusen.

Indian J Ophthalmol 2014 Dec;62(12):1146-51

Department of Neuro Ophthalmology, Sankara Nethralaya, A Unit of Medical Research Foundation, Nungambakkam, Chennai, Tamil Nadu, India.

Aim: To compare the spectral domain optical coherence tomography (SD-OCT) findings of the optic disc and the peripapillary retina of patients with a true papilledema and pseudopapilledema with and without optic nerve head drusen (ONHD).

Study Design: Retrospective Case Control Study.

Subjects And Methods: Peripapillary retinal nerve fiber layer (PPRNFL) thickness as depicted by SD-OCT of 94 eyes of 66 patients with papilledema (30 eyes), pseudopapiledema (31 eyes), and normal controls (33 eyes) was analyzed. Read More

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http://dx.doi.org/10.4103/0301-4738.149136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313495PMC
December 2014
5 Reads

The usefulness of multimodal imaging for differentiating pseudopapilloedema and true swelling of the optic nerve head: a review and case series.

Clin Exp Optom 2015 Jan 14;98(1):12-24. Epub 2014 Oct 14.

Centre for Eye Health, University of New South Wales, Kensington, New South Wales, Australia; School of Optometry and Vision Science, University of New South Wales, Kensington, New South Wales, Australia.

Ophthalmic practitioners have to make a critical differential diagnosis in cases of an elevated optic nerve head. They have to discriminate between pseudopapilloedema (benign elevation of the optic nerve head) and true swelling of the optic nerve head. This decision has significant implications for appropriate patient management. Read More

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http://dx.doi.org/10.1111/cxo.12177DOI Listing
January 2015
10 Reads

The role of orbital ultrasonography in distinguishing papilledema from pseudopapilledema.

Eye (Lond) 2014 Dec 5;28(12):1425-30. Epub 2014 Sep 5.

Division of Neuro-Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.

Purpose: To determine the sensitivity and specificity of orbital ultrasonography in distinguishing papilledema from pseudopapilledema in adult patients.

Methods: The records of all adult patients referred to the neuro-ophthalmology service who underwent orbital ultrasonography for the evaluation of suspected papilledema were reviewed. The details of history, ophthalmologic examination, and results of ancillary testing including orbital ultrasonography, MRI, and lumbar puncture were recorded. Read More

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http://dx.doi.org/10.1038/eye.2014.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268455PMC
December 2014
8 Reads

Optical coherence tomography in papilledema: what am I missing?

Authors:
Randy Kardon

J Neuroophthalmol 2014 Sep;34 Suppl:S10-7

Department of Ophthalmology and Visual Sciences, Neuro-Ophthalmology Division, University of Iowa, Hospitals and Clinics and Veterans Administration, Iowa City, Iowa.

Background: Grading of papilledema severity is subjective and based on monocular fundus features of the optic nerve. Interobserver agreement on grading the severity of papilledema is poor among expert observers, even using well-defined criteria such as the Frisen scale, which is a non-continuous ordinal scale of grading. Furthermore, non-expert clinicians often find it difficult to properly view and interpret features of the optic nerve using ophthalmoscopy, which can lead to failure to diagnose papilledema in non-ophthalmologic care settings. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000162DOI Listing
September 2014
10 Reads

Point-of-care ultrasonography for the identification of 2 children with optic disc drusen mimicking papilledema.

Pediatr Emerg Care 2014 Jul;30(7):505-7

From the *Pediatric Residency Program and †Division of Emergency Medicine, UCSF Benioff Children's Hospital Oakland, Oakland, CA.

We present 2 cases of asymptomatic patients who were found to have raised and blurred optic discs on physical examination, suggestive of papilledema. Evaluation in the emergency department revealed 2 well-appearing children with normal vital signs and neurologic evaluation results, without symptoms of increased intracranial pressure. Point-of-care ocular ultrasonography was performed on both children, demonstrating calcification at the optic nerve, which is diagnostic of optic disc drusen. Read More

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http://dx.doi.org/10.1097/PEC.0000000000000172DOI Listing
July 2014
3 Reads

Proteus syndrome: report of a case with developmental glaucoma.

Korean J Ophthalmol 2014 Jun 19;28(3):272-4. Epub 2014 May 19.

Department of Dermatology and Venereology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

The purpose of this study was to report developmental glaucoma and pseudopapilledema in a patient with Proteus syndrome. We defined the presence of developmental glaucoma, right pseudopapilledema and myopia in a 4.5-year-old patient with Proteus syndrome. Read More

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http://dx.doi.org/10.3341/kjo.2014.28.3.272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038735PMC
June 2014
6 Reads

Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography.

Am J Ophthalmol 2014 Jul 12;158(1):136-43. Epub 2014 Apr 12.

Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Purpose: To distinguish differences in retinal nerve fiber layer (RNFL) thickness and peripapillary total retinal volume between eyes with papilledema, pseudopapilledema, and normal findings.

Design: Cohort study.

Methods: Forty-two eyes with mild papilledema, 37 eyes with congenitally elevated optic disc (pseudopapilledema), and 34 normal eyes met the inclusion criteria at 1 academic institution (in Iran) and underwent neuro-ophthalmic examination. Read More

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http://dx.doi.org/10.1016/j.ajo.2014.03.008DOI Listing
July 2014
5 Reads

Retinal vessel diameter assessment in papilledema by semi-automated analysis of SLO images: feasibility and reliability.

Invest Ophthalmol Vis Sci 2014 Apr 3;55(4):2049-54. Epub 2014 Apr 3.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States.

Purpose: To report feasibility and reliability of a semi-automated image analysis method for retinal vessel diameter measurements in subjects with papilledema before and after treatment.

Methods: Scanning laser ophthalmoscopy (SLO) was performed in seven normal, five pseudopapilledema, and seven papilledema subjects. In four papilledema subjects, SLO was performed both before and following treatment. Read More

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http://dx.doi.org/10.1167/iovs.13-13621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979275PMC
April 2014
5 Reads

Pseudopapilledema and association with idiopathic intracranial hypertension.

Childs Nerv Syst 2014 Jul 27;30(7):1197-200. Epub 2014 Feb 27.

Washington University, St. Louis, MO, USA.

Purpose: Diagnosing idiopathic intracranial hypertension (IIH), or pseudotumor cerebri, can be challenging in children. Diagnosis is based on lumbar puncture, opening pressures, and appearance of the optic disk. Misdiagnosis of papilledema, a typical finding, may lead to unnecessary treatments and procedures. Read More

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http://dx.doi.org/10.1007/s00381-014-2390-yDOI Listing
July 2014
5 Reads

Using autofluorescence to detect optic nerve head drusen in children.

J AAPOS 2013 Dec 7;17(6):568-71. Epub 2013 Nov 7.

Ophthalmology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain; Health Sciences Faculty, Universidad Europea, Madrid, Spain. Electronic address:

Purpose: To assess the efficacy of using autofluorescence to identify optic nerve head drusen (ONHD) in children.

Methods: We conducted a cross-sectional, descriptive study of subjects <18 years of age with possible pseudopapilledema due to ONHD. B-scan ultrasonography was considered the gold standard diagnostic technique. Read More

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http://dx.doi.org/10.1016/j.jaapos.2013.07.012DOI Listing
December 2013
4 Reads

[Pseudopapilledema--optic disc drusen].

Harefuah 2013 Mar;152(3):154-7, 183, 182

Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Optic disc drusen (ODD) are benign calcified deposits, which are located at the head of the optic disc. Most ODD patients are asymptomatic. Ocular complications, related to ODD, are considered rare. Read More

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March 2013
3 Reads

The association of Alagille syndrome and craniosynostosis.

Pediatr Neurol 2013 Feb;48(2):146-8

Division of Child Neurology, Department of Pediatrics, Ege University Medical School, Izmir, Turkey.

Alagille syndrome is associated with various ocular abnormalities, including pseudopapilledema or optic disk edema due to increased intracranial pressure. Several mechanisms have been proposed to explain the mechanism of intracranial hypertension in Alagille syndrome. Craniosynostosis is an unusual but significant cause of increased intracranial hypertension in Alagille syndrome. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2012.10.014DOI Listing
February 2013
3 Reads

The swollen optic disc.

Br J Hosp Med (Lond) 2012 Nov;73(11):C166-9

University College Hospital, London NW1 2BU, UK.

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November 2012
4 Reads

The efficacy of optic nerve ultrasonography for differentiating papilloedema from pseudopapilloedema in eyes with swollen optic discs.

Acta Ophthalmol 2013 Jun 22;91(4):376-80. Epub 2011 Sep 22.

Department of Ophthalmology, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To evaluate the diagnostic yield of optic nerve ultrasonography (US) in distinguishing between papilloedema (swollen discs owing to raised intracranial pressure) and pseudopapilloedema.

Methods: We prospectively evaluated all patients with bilateral optic disc swelling who underwent a complete neuro-ophthalmological examination. Suitable patients were referred for neuroimaging (computerized tomography or magnetic resonance imaging) and lumbar puncture. Read More

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http://dx.doi.org/10.1111/j.1755-3768.2011.02253.xDOI Listing
June 2013
21 Reads

Adams-Oliver syndrome associated with bilateral anterior polar cataracts and optic disk drusen.

J AAPOS 2011 Jun;15(3):299-301

Princess Alexandra Eye Pavilion, Lothian NHS Trust, Chalmers Street, Edinburgh, UK.

Adams-Oliver syndrome (AOS) (MIM 100300) was first described in 1945 as a condition of terminal transverse limb defects and aplasia cutis congenita. Since then, its clinical features have been found to be highly variable and include cardiac defects, abdominal wall defects, vascular malformations, brain abnormalities, and ocular anomalies. We report the case of a 3-year-old girl with AOS who was also found to have bilateral anterior polar cataracts and pseudopapilledema secondary to optic disk drusen. Read More

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http://dx.doi.org/10.1016/j.jaapos.2011.02.012DOI Listing
June 2011
2 Reads

Analysis of the causes of optic disc swelling.

Korean J Ophthalmol 2011 Feb 17;25(1):33-6. Epub 2011 Jan 17.

Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.

Purpose: To investigate the clinical manifestations and diagnoses of optic disc swelling.

Methods: The medical records of 49 patients who experienced optic disc swelling between March 2008 and June 2009 were retrospectively reviewed. The characteristics of non-arteritic anterior ischemic optic neuropathy (NA-AION) and optic neuritis (ON), which showed optic disc swelling most commonly, were compared. Read More

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http://dx.doi.org/10.3341/kjo.2011.25.1.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039192PMC
February 2011
3 Reads

Use of optical coherence tomography to evaluate papilledema and pseudopapilledema.

Semin Ophthalmol 2010 Sep-Nov;25(5-6):198-205

Neuro-Ophthalmology Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

Idiopathic intracranial hypertension (IIH), or pseudotumor cerebri, describes a condition of elevated intracranial pressure (ICP) that typically presents in obese women of childbearing age with symptoms and signs of posture-dependent headaches, pulsatile tinnitus, visual changes, and papilledema. Optical coherence tomography (OCT) has begun to be utilized as an adjunctive, quantitative tool in the evaluation of patients with IIH to help distinguish between true optic nerve head edema and pseudopapilledema, and to contribute to our understanding of the consequences of prolonged optic nerve edema. Although few longitudinal studies of patients with IIH have been published to date, it appears that there may be a correlation between retinal nerve fiber layer (RNFL) thickness and visual function. Read More

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http://dx.doi.org/10.3109/08820538.2010.518462DOI Listing
April 2011
19 Reads

Optical coherence tomography as an adjunctive tool for diagnosing papilledema in young patients.

J Pediatr Ophthalmol Strabismus 2011 May-Jun;48(3):174-81. Epub 2010 Jul 22.

Division of Ophthalmology, Hillel-Yaffe Medical Center, Hadera, Israel.

Purpose: The authors examined the peripapillary (3.4-mm diameter) retinal nerve fiber layer thickness (RNFL thickness) as depicted by optical coherence tomography (OCT) in young patients with pseudopapilledema or papilledema.

Methods: In 17 consecutive patients (6 to 20 years old) with bilateral newly diagnosed papilledema or pseudopapilledema, the eye with the thicker mean global RNFL per patient was analyzed. Read More

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http://dx.doi.org/10.3928/01913913-20100719-05DOI Listing
October 2013
2 Reads

An atypical case of optic disk drusen with nerve fiber layer thickening.

Eye Brain 2010 26;2:67-71. Epub 2010 May 26.

Fırat University School of Medicine, Department of Ophthalmology, Elazig, Turkey.

We report an atypical case of optic disk drusen (ODD). A 12-year-old girl complained of blurred vision in both eyes. However, visual acuities in both eyes were 20/20. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436170PMC
May 2010
10 Reads

Pseudopapilledema in Kenny-Caffey syndrome.

J Pediatr Ophthalmol Strabismus 2011 21;48 Online:e1-3. Epub 2010 May 21.

Service d’Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Hôpital Pierre Zobda-Quitman, BP 632, 97261 Fort de France Cedex, Martinique, France.

A 21-year-old man with Kenny-Caffey syndrome had been observed since 1993 for hyperopia. Fundus examination revealed swollen optic disks. Further examinations (fluorescein angiography, B-scan ultrasonography, and optical coherence tomography) confirmed the optic nerve head elevation. Read More

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http://dx.doi.org/10.3928/01913913-20090918-03DOI Listing
September 2015
7 Reads

Post-inflammatory retinal dystrophy in CINCA syndrome.

Rheumatol Int 2010 Jan 8;30(3):389-93. Epub 2009 May 8.

Department of Pediatric Sciences, Center of Periodic Fevers, Università Cattolica Sacro Cuore, Largo A. Gemelli no. 8, 00168 Rome, Italy.

Right chorioretinitis and bilateral pseudopapilledema were firstly appreciated in a 9-month-old child with neonatal findings of aseptic chronic meningitis, framed in the context of CINCA syndrome at 1 year. Therapeutical response to various combinations of drugs was inconsistent until 7 years, when anakinra was started with immediate clinical and laboratory improvement. A state of severe retinal dystrophy of post-inflammatory origin became evident on funduscopy, optical coherence tomography and visual electrophysiology tests at the age of 10 years, which remained stationary after 1 year of anakinra treatment. Read More

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http://dx.doi.org/10.1007/s00296-009-0939-yDOI Listing
January 2010
7 Reads
3 Citations
1.630 Impact Factor