Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection.
- Bryan J Berube,
- Katherine R Murphy,
- Matthew C Torhan,
- Nicholas O Bowlin,
- John D Williams,
- Terry L Bowlin,
- Donald T Moir,
- Alan R Hauser
Antimicrob Agents Chemother 2017 Nov 24;61(11). Epub 2017 Oct 24.
Department of Microbiology/Immunology, Northwestern University, Chicago, Illinois, USA
is a leading cause of intra-abdominal infections, wound infections, and community-acquired folliculitis, each of which may involve macro- or microabscess formation. The rising incidence of multidrug resistance among isolates has increased both the economic burden and the morbidity and mortality associated with disease and necessitates a search for novel therapeutics. Previous work from our group detailed novel phenoxyacetamide inhibitors that block type III secretion and injection into host cells In this study, we used a mouse model of abscess formation to test the efficacy of these compounds against the type III secretion system (T3SS). Read More