39,430 results match your criteria Pseudomonas Aeruginosa Infections


Microbiological profile of leg ulcer infections: review study.

Rev Bras Enferm 2021 18;74(3):e20190763. Epub 2021 Jun 18.

Universidade Federal de Minas Gerais. Belo Horizonte, Minas Gerais, Brazil.

Objectives: to analyze the microbiological profile of leg ulcers of patients treated at outpatient clinics and hospitals regarding the type of microorganism, microbiological selection of antibiotics, and techniques for the collection of culture material.

Methods: literature review performed on LILACS, IBECS, MEDLINE, and CINAHL databases, resulting in a descriptive analysis of 27 studies.

Results: 35. Read More

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Genome-wide association study of signature genetic alterations among pseudomonas aeruginosa cystic fibrosis isolates.

PLoS Pathog 2021 Jun 23;17(6):e1009681. Epub 2021 Jun 23.

Department of Microbiology and Immunology, Seoul, Republic of Korea.

Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes diverse human infections including chronic airway infection in patients with cystic fibrosis (CF). Comparing the genomes of CF and non-CF PA isolates has great potential to identify the genetic basis of pathogenicity. To gain a deeper understanding of PA adaptation in CF airways, we performed a genome-wide association study (GWAS) on 1,001 PA genomes. Read More

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Evolution of the Antimicrobial resistance of Bacteria causing Urinary Tract Infections.

Comb Chem High Throughput Screen 2021 Jun 22. Epub 2021 Jun 22.

Basic Science Department, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region. Iraq.

Background: The bacteria, Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae), are the main reasons for urinary tract infections (UTIs). Read More

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Cefiderocol treatment of Pseudomonas aeruginosa and extensively drug-resistant Acinetobacter baumannii retained spinal hardware infection causing reversible acute interstitial nephritis.

Int J Infect Dis 2021 Jun 19. Epub 2021 Jun 19.

Department of Infectious Diseases, Immunology & Sexual Health, St George Hospital, Sydney, New South Wales, Australia.; St George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

Infections with extensively drug-resistant Acinetobacter baumannii (XDRAB) have limited therapeutic options. We report successful salvage treatment of XDRAB and Pseudomonas aeruginosa infected, retained spinal hardware with cefiderocol, despite development of reversible acute interstitial nephritis after 32 days of treatment. Read More

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Filamentous Bacteriophages and the Competitive Interaction between Pseudomonas aeruginosa Strains under Antibiotic Treatment: a Modeling Study.

mSystems 2021 Jun 22:e0019321. Epub 2021 Jun 22.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

Pseudomonas aeruginosa () is a major bacterial pathogen responsible for chronic lung infections in cystic fibrosis patients. Recent work has implicated Pf bacteriophages, nonlytic filamentous viruses produced by , in the chronicity and severity of infections. Pf phages act as structural elements in biofilms and sequester aerosolized antibiotics, thereby contributing to antibiotic tolerance. Read More

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Untargeted Metabolomics Reveals Species-Specific Metabolite Production and Shared Nutrient Consumption by Pseudomonas aeruginosa and Staphylococcus aureus.

mSystems 2021 Jun 22:e0048021. Epub 2021 Jun 22.

Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.

While bacterial metabolism is known to impact antibiotic efficacy and virulence, the metabolic capacities of individual microbes in cystic fibrosis lung infections are difficult to disentangle from sputum samples. Here, we show that untargeted metabolomic profiling of supernatants of multiple strains of Pseudomonas aeruginosa and Staphylococcus aureus grown in monoculture in synthetic cystic fibrosis media (SCFM) reveals distinct species-specific metabolic signatures despite intraspecies metabolic variability. We identify a set of 15 metabolites that were significantly consumed by both P. Read More

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Recommendations of the AFU Infectious Diseases Committee on the prevention, diagnosis and treatment of infections of endo-ureteral equipment.

Prog Urol 2021 Jun 18. Epub 2021 Jun 18.

Service d'Urologie, CHRU Bretonneau, Tours, France.

Introduction: No recent national guidelines exist regarding the management of urinary tract infections (UTIs) in the presence of ureteral stent. This situation could lead to discrepancies in clinical management and less opportunity for a favorable patient's outcome.

Methods: All available data published on Medline® between 1998 and 2018 were systematically searched and reviewed. Read More

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A Primed Subpopulation of Bacteria Enables Rapid Expression of the Type 3 Secretion System in Pseudomonas aeruginosa.

mBio 2021 Jun 22:e0083121. Epub 2021 Jun 22.

Department of Medicine (Infectious Diseases), Yale University, New Haven, Connecticut, USA.

Type 3 secretion systems (T3SS) are complex nanomachines that span the cell envelope and play a central role in the biology of Gram-negative pathogens and symbionts. In Pseudomonas aeruginosa, T3SS expression is strongly associated with human disease severity and with mortality in murine acute pneumonia models. Uniform exposure of isogenic cells to T3SS-activating signal results in heterogeneous expression of this critical virulence trait. Read More

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Monoclonal antibody directed to the PilQ -PilA DSL region in Pseudomonas aeruginosa improves survival of infected mice with antibiotic combination.

Microb Pathog 2021 Jun 18:105060. Epub 2021 Jun 18.

Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

The infections caused by Pseudomonas aeruginosa are related to high mortality and morbidity in critically ill patients because of multidrug resistance. Thus, we performed the efficacy of the monoclonal antibody (mAb) against PilQ -PilA DSL region (QA) in combination with antibiotics in a model of P. aeruginosa infection. Read More

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A non-lethal murine flame burn model leads to a transient reduction in host defenses and enhanced susceptibility to lethal infection.

Infect Immun 2021 Jun 21:IAI0009121. Epub 2021 Jun 21.

Center for Vaccine Development and Global Health, University of Maryland, School of Medicine, Baltimore, MD.

Of the 486,000 burn injuries that required medical treatment in the USA in 2016, 40,000 people were hospitalized, with > 3,000 fatalities. After burn injury, humans are at increased risk of sepsis and mortality from infections caused by (PA), an opportunistic pathogen. We hypothesize that systemic events were initiated from the burn that increased the host's susceptibility to PA. Read More

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Bacterial Disease Complex Including Bleached Spot, Soft Rot, and Blight on Onion Seedlings caused by Complex Infections.

Plant Dis 2021 Jun 21. Epub 2021 Jun 21.

Gyeongsang National University, Applied Biology, 900 Gajwa, Jinju, Korea (the Republic of), 660-701;

In 2018, a bacterial disease complex (BDC) comprised of bleached spots and soft rot-blight on onion seedlings was observed in nursery beds in Changnyeong, a major onion-producing county in South Korea. Four bacteria isolated from the diseased lesions were identified: Pseudomonas viridiflava (Pvi), Acidovorax avenae subsp. avenae (Aaa), Pantoea ananatis (Pan), and Xanthomonas axonopodis (Xax), respectively. Read More

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Photoactive Silver Nanoagents for Backgroundless Monitoring and Precision Killing of Multidrug-Resistant Bacteria.

Nanotheranostics 2021 1;5(4):472-487. Epub 2021 Jun 1.

State Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, China.

The growing prevalence of multidrug-resistant (MDR) bacteria makes it clinically urgent to develop an agent able to detect and treat infections simultaneously. Silver has served as a broad-spectrum antimicrobial since ancient times but suffers from major challenges such as moderate antimicrobial activity, nonspecific toxicity, and difficulty to be visualized . Here, we propose a new photoactive silver nanoagent that relies on a photosensitizer-triggered cascade reaction to liberate Ag on bacterial surfaces exclusively, allowing the precise killing of MDR bacteria. Read More

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A comparative study on antibacterial activity of carvacrol and glutaraldehyde on and isolates: an in vitro study.

J Environ Health Sci Eng 2021 Jun 10;19(1):475-482. Epub 2021 Feb 10.

Razi Herbal Medicines Research Center and Department of Environmental Health, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.

The resistance of hospital bacterial isolates against traditional germicides, which used frequently, is one of the important factors contributing to emerging nosocomial infections. Moreover, due to having the side effects of chemical substances, the development of novel low-risk natural compounds seems necessary for control the spread of resistant pathogens in hospital environments. The aim of this study was to compare the effect of carvacrol and glutaraldehyde against two common hospital acquired pathogens, including and . Read More

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New drugs for difficult bugs: management of multidrug-resistant gram-negative infections in solid organ transplant recipients.

Curr Opin Organ Transplant 2021 Jun 18. Epub 2021 Jun 18.

Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose Of Review: Multidrug-resistant Gram-negative bacteria remain a significant threat to patient and allograft survival. Management of these infections in solid organ transplant (SOT) recipients remains challenging due to a limited antimicrobial pipeline and reliance on novel agents, which have not been systematically evaluated in the transplant population.

Recent Findings: Novel antimicrobials, including the second-generation β-lactam/β-lactamase inhibitors, cefiderocol, plazomicin and eravacycline, have been developed to combat infections due to multidrug-resistant Gram-negative infections, but each has microbiologic and therapeutic niches and warrant further study in SOT recipients. Read More

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The burden of central line-associated bloodstream infections in children with medical complexity.

J Vasc Access 2021 Jun 21:11297298211027468. Epub 2021 Jun 21.

Bambino Gesù Pediatric Hospital, Rome, Italy.

Background: Central line-associated bloodstream infections (CLABSI) are significant cause of complications in pediatric intensive care units (PICUs). An emerging challenge are CLABSIs in children with medical complexity (CMC) admitted to PICU. CMC are patients with chronic conditions with or without neurological impairment needing for tracheostomy and/or home mechanical or non-invasive ventilation and/or gastrostomy/jejunostomy. Read More

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PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections.

Biochim Biophys Acta Gen Subj 2021 Jun 17:129951. Epub 2021 Jun 17.

Faculty of Veterinary Medicine, Department of Biomolecular Health Sciences, Division Infectious Diseases & Immunology, Section Molecular Host Defence, Utrecht University, the Netherlands.

Background: Antimicrobial peptides are considered potential alternatives for antibiotics. Here we describe the antibacterial properties of a family of novel cathelicidin-related (CR-) peptides, which we named PepBiotics, against bacteria typically present in cystic fibrosis (CF) patients.

Methods: Broth dilution assays were used to determine antibacterial activity of PepBiotics under physiological conditions, as well as development of bacterial resistance against these peptides. Read More

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Factors Contributing to Peritonitis in Peritoneal Dialysis: Comparing Triple Cuff Saudi Catheter to Double Cuff Tenckhoff Catheter: A 12-Year Observational Study.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):69-83

Department of Internal Medicine, Division of Nephrology, King Fahd Hospital of the University, Alkhobar, Saudi Arabia.

Very few detailed descriptive studies focusing on peritonitis in patients on peritoneal dialysis (PD) have been published. Most of the current information is available through from either study with the limited number of patients or isolated case reports. We conducted an observational study of our PD-peritonitis database over the past 12 years to study the clinical profile and the outcomes of peritonitis episodes in our PD center. Read More

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Semiparametric estimation of the proportional rates model for recurrent events data with missing event category.

Stat Methods Med Res 2021 Jun 18:9622802211023975. Epub 2021 Jun 18.

Department of Medicine, University of North Carolina at Chapel Hill, NC, USA.

Proportional rates models are frequently used for the analysis of recurrent event data with multiple event categories. When some of the event categories are missing, a conventional approach is to either exclude the missing data for a complete-case analysis or employ a parametric model for the missing event type. It is well known that the complete-case analysis is inconsistent when the missingness depends on covariates, and the parametric approach may incur bias when the model is misspecified. Read More

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First Report of Shot-hole on Flowering Cherry Caused by and pv. .

Plant Dis 2021 Jun 18. Epub 2021 Jun 18.

Chonnam National University College of Agriculture and Life Sciences, 98413, 77 Yongbong-ro, Buk-gu, Gwangju, Korea (the Republic of), 61186;

The shot-hole disease (SH) is one of the most common and important diseases affecting the flowering cherry (FC; Matsumura; 'Somei-yoshino') trees in South Korea every year, resulting in premature defoliation and reduced flowering in the following year. However, pathogens associated with the disease remain unknown, which has rendered disease management challenging. Here, the pathogens associated with SH, their biochemical characteristics, and their host range were elucidated. Read More

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Pyocin efficacy in a murine model of Pseudomonas aeruginosa sepsis.

J Antimicrob Chemother 2021 Jun 18. Epub 2021 Jun 18.

Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davis Building, University Place, Glasgow, G12 8TA, UK.

Background: Bloodstream infections with antibiotic-resistant Pseudomonas aeruginosa are common and increasingly difficult to treat. Pyocins are naturally occurring protein antibiotics produced by P. aeruginosa that have potential for human use. Read More

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A prospective surveillance study to determine the prevalence of 16S rRNA methyltransferase-producing Gram-negative bacteria in the UK.

J Antimicrob Chemother 2021 Jun 18. Epub 2021 Jun 18.

National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

Objectives: To determine the prevalence of 16S rRNA methyltransferase- (16S RMTase-) producing Gram-negative bacteria in patients in the UK and to identify potential risk factors for their acquisition.

Methods: A 6 month prospective surveillance study was conducted from 1 May to 31 October 2016, wherein 14 hospital laboratories submitted Acinetobacter baumannii, Enterobacterales and Pseudomonas aeruginosa isolates that displayed high-level amikacin resistance according to their testing methods, e.g. Read More

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A Sequence Type 23 Hypervirulent Strain Presenting Carbapenem Resistance by Acquiring an IncP1 Plasmid.

Front Cell Infect Microbiol 2021 1;11:641830. Epub 2021 Jun 1.

Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Hypervirulent strains are typically associated with severe infections and susceptible to most antimicrobial agents. In 2017, a carbapenem-resistant hypervirulent (CR-hvKP) strain was isolated from the sputum of a chronic obstructive pulmonary disease (COPD) patient in Zhejiang, China. The goal of the present study was to characterize the molecular features of the CR-hvKP isolate ZJ27003 and its -harboring plasmid p27003_KPC. Read More

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Biofilm inhibition and antifouling evaluation of sol-gel coated silicone implants with prolonged release of eugenol against .

Biofouling 2021 Jun 17:1-17. Epub 2021 Jun 17.

Renal Research Lab, Centre for Bio-Medical Research, School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore, India.

The incidence of biofilm-linked catheter-associated urinary tract infections (CAUTIs) is increasing across the world. However, there is no clinical evidence to support the modifications of biomaterials, such as antimicrobial agent-coated catheters, that are known to reduce the risk of bacterial colonization and resistance development. The present study developed and tested silicone segments coated with an antivirulence agent, eugenol. Read More

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[Epidemiological investigation and analysis of etiological characteristics of infection on 3067 hospitalized pediatric patients with burns].

Zhonghua Shao Shang Za Zhi 2021 May 31;37:1-8. Epub 2021 May 31.

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

To investigate the epidemiological characteristics and etiological distribution of infection on 3067 hospitalized pediatric patients with burns, and explore the prevention and treatment strategy of pediatric burns. A cross-sectional survey was conducted. Retrospective analysis was performed on the data of 3067 hospitalized pediatric patients with burns who met the inclusion criteria and admitted to the First Affiliated Hospital of Army Medical University (the Third Military Medical University) from January 2012 to December 2020, including gender, ages, burns types, locations, severities of burns, and seasons of accidents, and type of pathogenic bacteria, source of tissue or body fluid, and drug resistance. Read More

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Development of a multiplex real-time PCR assay for the simultaneous detection of four bacterial pathogens causing pneumonia.

PLoS One 2021 17;16(6):e0253402. Epub 2021 Jun 17.

Department of Molecular Diagnostics, Seegene Medical Foundation, Seoul, Republic of Korea.

Classification of clinical symptoms and diagnostic microbiology are essential to effectively employ antimicrobial therapy for lower respiratory tract infections (LRTIs) in a timely manner. Empirical antibiotic treatment without microbial identification hinders the selective use of narrow-spectrum antibiotics and effective patient treatment. Thus, the development of rapid and accurate diagnostic procedures that can be readily adopted by the clinic is necessary to minimize non-essential or excessive use of antibiotics and accelerate patient recovery from LRTI-induced damage. Read More

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Epidemiological and Clinical Characterization of Superinfections in Critically Ill Coronavirus Disease 2019 Patients.

Crit Care Explor 2021 Jun 11;3(6):e0430. Epub 2021 Jun 11.

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

To describe the epidemiology of superinfections (occurring > 48 hr after hospital admission) and their impact on the ICU and 28-day mortality in patients with coronavirus disease 2019 with acute respiratory distress syndrome, requiring mechanical ventilation.

Design: Retrospective analysis of prospectively collected observational data.

Setting: University-affiliated adult ICU. Read More

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Biofilm Formation by Pathogens Causing Ventilator-Associated Pneumonia at Intensive Care Units in a Tertiary Care Hospital: An Armor for Refuge.

Biomed Res Int 2021 28;2021:8817700. Epub 2021 May 28.

Department of Clinical Microbiology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Background: Emerging threat of drug resistance among pathogens causing ventilator-associated pneumonia (VAP) has resulted in higher hospital costs, longer hospital stays, and increased hospital mortality. Biofilms in the endotracheal tube of ventilated patients act as protective shield from host immunity. They induce chronic and recurrent infections that defy common antibiotics. Read More

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A New Optical Fiber Probe-Based Quantum Dots Immunofluorescence Biosensors in the Detection of .

Front Cell Infect Microbiol 2021 31;11:665241. Epub 2021 May 31.

State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instruments, Tsinghua University, Beijing, China.

() is one of the most common clinical pathogenic bacteria with strong pathogenicity and usually leads to various suppurative infections with high fatality. Traditional bacterial culture for the detection of is prone to diagnosis and antimicrobial treatment delays because of its long-time consumption and low sensitivity. In this study, we successfully developed a quantum dots immunofluorescence biosensor for detection. Read More

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Synergistic Activity and Biofilm Formation Effect of Colistin Combined with PFK-158 Against Colistin-Resistant Gram-Negative Bacteria.

Infect Drug Resist 2021 9;14:2143-2154. Epub 2021 Jun 9.

Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China.

Purpose: The emergence of colistin resistance among Gram-negative bacteria (GNB) poses a serious public health threat. Therefore, it is necessary to enhance the antibacterial activity of colistin through the combination with other drugs. In this study, we demonstrated the synergistic activity and the possible synergy mechanism of colistin with PFK-158 against colistin-resistant GNB, including non-fermenting bacteria and Enterobacteriaceae. Read More

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Polymer-induced microcolony compaction in early biofilms: A computer simulation study.

Phys Rev E 2021 May;103(5-1):052407

Department of Physical, Chemical and Natural Systems, Pablo de Olavide University, 41013 Sevilla, Spain.

Microscopic organisms, such as bacteria, have the ability of colonizing surfaces and developing biofilms that can determine diseases and infections. Most bacteria secrete a significant amount of extracellular polymer substances that are relevant for biofilm stabilization and growth. In this work, we apply computer simulation and perform experiments to investigate the impact of polymer size and concentration on early biofilm formation and growth. Read More

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