35,101 results match your criteria Pseudomonas Aeruginosa Infections


Allicin inhibits Pseudomonas aeruginosa virulence by suppressing the rhl and pqs quorum-sensing systems.

Can J Microbiol 2019 Apr 22. Epub 2019 Apr 22.

Army Medical University, 12525, Central Laboratory, Xinqiao Hospital, Chongqing, Chongqing, China ;

Pseudomonas aeruginosa (P. aeruginosa) is a virulent bacterium that secretes a variety of virulence factors that aid in establishing infections in individuals. Allicin, derived from garlic, has been shown to inhibit virulence factor production and biofilm formation in P. Read More

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http://dx.doi.org/10.1139/cjm-2019-0055DOI Listing

Microbiological profile and antibiotic susceptibility of scleral buckle infections in North India.

Indian J Ophthalmol 2019 May;67(5):644-647

Microbiology Services, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Purpose: The aim of this article to study causative organisms for scleral buckle (SB) infections in North India.

Methods: A retrospective review of records was done for all patients who have undergone SB removal at our institute between January 2009 and December 2017. The records were analyzed for etiological agent of the infected buckle and its antibiotic sensitivity. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1094_18DOI Listing

Generation of a highly attenuated strain of Pseudomonas aeruginosa for commercial production of alginate.

Microb Biotechnol 2019 Apr 21. Epub 2019 Apr 21.

Robert C. Byrd Biotechnology Science Center, Progenesis Technologies, LLC, One John Marshall Drive, Suite 314, Huntington, WV, 25755, USA.

Alginate is an important polysaccharide that is commonly used as a gelling agent in foods, cosmetics and healthcare products. Currently, all alginate used commercially is extracted from brown seaweed. However, with environmental changes such as increasing ocean temperature and the increasing number of biotechnological uses of alginates with specific properties, there is an emerging need for more reliable and customizable sources of alginate. Read More

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http://dx.doi.org/10.1111/1751-7915.13411DOI Listing

Developments on antibiotics for multidrug resistant bacterial Gram-negative infections.

Expert Rev Anti Infect Ther 2019 Apr 20. Epub 2019 Apr 20.

a Alfa Institute of Biomedical Sciences , Athens , Greece.

Introduction: The constantly increasing spread of severe infections due to multi-drug resistant (MDR) Gram-negative bacteria (GNB) is a critical threat to the global medical community. After a long period of antibiotic pipeline pause, new antibiotic compounds are commercially available or are at late stages of clinical evaluation, promising to augment the therapeutic armamentarium of clinicians against deadly pathogens. Areas covered: This review summarizes available data regarding agents with potent activity against critical MDR Gram-negative pathogens, which urgently require new efficient antibiotics. Read More

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http://dx.doi.org/10.1080/14787210.2019.1610392DOI Listing

Efflux pump inhibitors of clinically relevant multidrug resistant bacteria.

Med Res Rev 2019 Apr 19. Epub 2019 Apr 19.

Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.

Bacterial infections are an increasingly serious issue worldwide. The inability of existing therapies to treat multidrug-resistant pathogens has been recognized as an important challenge of the 21st century. Efflux pumps are important in both intrinsic and acquired bacterial resistance and identification of small molecule efflux pump inhibitors (EPIs), capable of restoring the effectiveness of available antibiotics, is an active research field. Read More

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http://dx.doi.org/10.1002/med.21591DOI Listing

A comparative analysis of infection in patients with malignant cancer: A clinical pharmacist consultation study.

J Infect Public Health 2019 Apr 17. Epub 2019 Apr 17.

Department of Oncology, Peking University International Hospital, Beijing 102206, China. Electronic address:

Background: Infection analysisamongst malignant cancer patients remains elusive. The objective of this study is to investigate the characteristics of both infection and anti-infection treatments in patients group with malignant cancer.

Methods: We retrospectively studied the clinical data of 148 patients with malignant cancer and 171 benign patients enrolled in the pharmacist consultation from April 2015 to April 2017. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.021DOI Listing

The Effect of Recombinant Human Erythropoietin on Bacterial Growth: A Dual-Edged Sword.

Kidney Dis (Basel) 2019 Mar 13;5(2):81-90. Epub 2018 Nov 13.

Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Hypererythropoietinemia is associated with common diseases like non-uremic anaemia where infection burden is high. Erythropoietin (EPO) is also given as therapy for anaemia associated with chronic kidney disease and cancer and in those who are at a higher risk of infections. EPO is known to have an effect on macrophages by which it helps in the growth of some intracellular pathogens. Read More

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https://www.karger.com/Article/FullText/493684
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http://dx.doi.org/10.1159/000493684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468308PMC
March 2019
3 Reads

Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis.

Front Pharmacol 2019 2;10:252. Epub 2019 Apr 2.

Department of Medical, Oral and Biotechnological Science, Università "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.

Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. Resolution of inflammation is an active process timely controlled by endogenous specialized pro-resolving lipid mediators (SPMs) produced locally in inflammatory loci to restrain this innate response, prevent further damages to the host, and permit return to homeostasis. Lipoxins, resolvins, protectins, and maresins are SPM derived from polyunsaturated fatty acids that limit excessive leukocyte infiltration and pro-inflammatory signals, stimulate innate microbial killing, and enhance resolution. Read More

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http://dx.doi.org/10.3389/fphar.2019.00252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454233PMC
April 2019
1 Read

Prevalence of health care-associated infections and antimicrobial resistance of the responsible pathogens in Ukraine: Results of a multicenter study (2014-2016).

Am J Infect Control 2019 Apr 15. Epub 2019 Apr 15.

Department of Anatomy, Topographical Anatomy, and Operative Surgery, Private Higher Educational Establishment "Kyiv Medical University," Kyiv, Ukraine.

Background: The aim of this study was to obtain the first national estimates of the current prevalence and incidence and death of health care-associated infections (HAIs) of all types in acute care hospitals in Ukraine.

Methods: Prospective surveillance was conducted from January 2014 to December 2016 in 17 hospitals. Surveillance case definitions were derived from the Centers for Disease Control and Prevention's National Healthcare Safety Network HAI case definitions. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.007DOI Listing

The prevalence of and multidrug resistant in healthy captive ophidian.

PeerJ 2019 12;7:e6706. Epub 2019 Apr 12.

Department of Veterinary Science, University of Parma, Parma, Italy.

Background: Snakes are globally considered as pet animals, and millions of ophidians are bred in captivity. is a ubiquitous Gram-negative bacterium that can act as an opportunistic pathogen of man and animals and is frequently present in the oral and cloacal microbiota of healthy ophidians. It can cause severe clinical diseases and often shows antibiotic resistance. Read More

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https://peerj.com/articles/6706
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http://dx.doi.org/10.7717/peerj.6706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463849PMC
April 2019
1 Read

A Live Vaccine Delivering PcrV through the Type III Secretion System Protects against Pseudomonas aeruginosa.

mSphere 2019 Apr 17;4(2). Epub 2019 Apr 17.

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain

is a common Gram-negative opportunistic pathogen that is intrinsically resistant to a wide range of antibiotics. The development of a broadly protective vaccine against remains a major challenge. Here, we used an attenuated strain of serovar Typhimurium as a vehicle to express antigens. Read More

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http://dx.doi.org/10.1128/mSphere.00116-19DOI Listing
April 2019
1 Read

Filamentous bacteriophages are associated with chronic lung infections and antibiotic resistance in cystic fibrosis.

Sci Transl Med 2019 Apr;11(488)

Center for Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.

Filamentous bacteriophage (Pf phage) contribute to the virulence of infections in animal models, but their relevance to human disease is unclear. We sought to interrogate the prevalence and clinical relevance of Pf phage in patients with cystic fibrosis (CF) using sputum samples from two well-characterized patient cohorts. Bacterial genomic analysis in a Danish longitudinal cohort of 34 patients with CF revealed that 26. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau9748DOI Listing
April 2019
1 Read

Rates, Predictors and Mortality of Community-Onset Bloodstream Infections due to Pseudomonas aeruginosa: Systematic Review and Meta-Analysis.

Clin Microbiol Infect 2019 Apr 14. Epub 2019 Apr 14.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena / Departamento de Medicina, Universidad de Sevilla / Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain.

Background: Pseudomonas aeruginosa is mostly a nosocomial pathogen affecting predisposed patients. However, community-onset bloodstream infections (CO-BSI) caused by this organism are not exceptional.

Objectives: To assess the predisposing factors for CO-BSI due to P. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.005DOI Listing
April 2019
1 Read

Borneo herbal plant extracts as a natural medication for prophylaxis and treatment of and infection in tilapia ( ).

F1000Res 2018 26;7:1847. Epub 2018 Nov 26.

Department of Fisheries, Faculty of Fisheries and Marine Science, Padjajaran University, Bandung, West Java, 40600, Indonesia.

The combination of some plant extracts to prevent and treat bacterial infections is gaining momentum, because of effectiveness against certain bacteria. This study aims to describe the antibacterial and immunostimulant abilities of (BP), (SF) and (ZZ) plant extracts to treat and prevent and infection on Tilapia ( ). Tilapia (initial weight 15±2 g) were injected intramuscularly (0. Read More

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https://f1000research.com/articles/7-1847/v1
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http://dx.doi.org/10.12688/f1000research.16902.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439779PMC
November 2018
1 Read

Coenzyme Q biosynthesis in the biopesticide Shenqinmycin-producing Pseudomonas aeruginosa strain M18.

J Ind Microbiol Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

Coenzyme Q (ubiquinone) is a redox-active isoprenylated benzoquinone commonly found in living organisms. The biosynthetic pathway for this lipid has been extensively studied in Escherichia coli and Saccharomyces cerevisiae; however, little is known in Pseudomonas aeruginosa. In this study, we observed that CoQ is the predominant coenzyme Q synthesized by the Shenqinmycin-producing strain M18. Read More

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http://link.springer.com/10.1007/s10295-019-02179-1
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http://dx.doi.org/10.1007/s10295-019-02179-1DOI Listing
April 2019
2 Reads

Nosocomial infections in surgical intensive care unit: A retrospective single-center study.

Int J Crit Illn Inj Sci 2019 Jan-Mar;9(1):16-20

Department of Anaesthesiology and Critical Care, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India.

Aims: This study aims to study the incidence, microbiological and antibiotic sensitivity and resistance profile and impact on intensive care units (ICUs) stay and mortality of nosocomial infections in patients admitted to surgical ICU of our hospital.

Methods: A retrospective analysis of all patients admitted, over the course of 1 year, in the surgical ICU was undertaken. All patients who developed nosocomial infections were included in the study. Read More

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http://www.ijciis.org/text.asp?2019/9/1/16/253764
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http://dx.doi.org/10.4103/IJCIIS.IJCIIS_57_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423928PMC
April 2019
3 Reads

Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review.

Front Microbiol 2019 1;10:539. Epub 2019 Apr 1.

Department of Microbiology, Savitribai Phule Pune University, Pune, India.

The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance and virulence: , and spp. Persistent use of antibiotics has provoked the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) bacteria, which render even the most effective drugs ineffective. Extended spectrum β-lactamase (ESBL) and carbapenemase producing Gram negative bacteria have emerged as an important therapeutic challenge. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00539
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http://dx.doi.org/10.3389/fmicb.2019.00539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452778PMC
April 2019
1 Read

In vitro activity of cefepime-enmetazobactam against Gram-negative isolates collected from United States and European hospitals during 2014-2015.

Antimicrob Agents Chemother 2019 Apr 15. Epub 2019 Apr 15.

Allecra Therapeutics SAS, St-Louis, France

Enmetazobactam, formerly AAI101, is a novel penicillanic acid sulfone extended-spectrum β-lactamase inhibitor. The combination of enmetazobactam with cefepime has entered clinical trials to assess safety and efficacy in patients with complicated urinary tract infections. Here, the in vitro activity of cefepime-enmetazobactam was determined for 1,993 clinical isolates of Enterobacteriaceae and collected in the US and Europe during 2014 and 2015. Read More

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http://dx.doi.org/10.1128/AAC.00514-19DOI Listing

Treatment with the glycoside hydrolase PslG combats wound infection by improving antibiotic efficacy and host innate immune activity.

Antimicrob Agents Chemother 2019 Apr 15. Epub 2019 Apr 15.

Department of Microbiology, University of Washington, Seattle, Washington, United States of America

is an opportunistic, nosocomial bacterial pathogen that forms persistent infections due to the formation of protective communities, known as biofilms. Once formed, the bacteria embedded within the biofilm are recalcitrant to antimicrobial treatment and host immune defenses. Moreover, the presence of biofilms in wounds is correlated with chronic infection and delayed healing. Read More

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http://dx.doi.org/10.1128/AAC.00234-19DOI Listing

Fucoidan-Stabilized Gold Nanoparticle-Mediated Biofilm Inhibition, Attenuation of Virulence and Motility Properties in PAO1.

Mar Drugs 2019 Apr 3;17(4). Epub 2019 Apr 3.

Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea.

The emergence of antibiotic resistance in due to biofilm formation has transformed this opportunistic pathogen into a life-threatening one. Biosynthesized nanoparticles are increasingly being recognized as an effective anti-biofilm strategy to counter biofilms. In the present study, gold nanoparticles (AuNPs) were biologically synthesized and stabilized using fucoidan, which is an active compound sourced from brown seaweed. Read More

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https://www.mdpi.com/1660-3397/17/4/208
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http://dx.doi.org/10.3390/md17040208DOI Listing
April 2019
1 Read

Interactions of Pseudomonas aeruginosa with Acanthamoeba polyphaga Observed by Imaging Flow Cytometry.

Cytometry A 2019 Apr 15. Epub 2019 Apr 15.

School of Public Health, University of Alberta, Edmonton, Alberta, Canada.

Pseudomonas aeruginosa is a Gram-negative bacterium that is abundant in the environment and water systems, with strains that cause serious infections, especially in patients with compromised immune systems. In times of stress or as part of its natural life cycle, P. aeruginosa can adopt a viable but not culturable (VBNC) state, which renders it undetectable by current conventional food and water testing methods and makes it highly resistant to antibiotic treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cyto.a.23768
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http://dx.doi.org/10.1002/cyto.a.23768DOI Listing
April 2019
4 Reads

Prognostic Value of Concomitant Bronchiectasis in Newly Diagnosed Diffuse Panbronchiolitis Patients on a Maintenance Therapy with Macrolides.

Can Respir J 2019 10;2019:4913814. Epub 2019 Mar 10.

Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

Background: Factors determining the prognosis of diffuse panbronchiolitis (DPB) remain unclear at present. The objective of this study was to identify the prognostic value of concomitant bronchiectasis in the macrolide treatment efficacy and exacerbation risk in DPB patients.

Methods: Data of patients initially diagnosed with DPB at the Shanghai Pulmonary Hospital between January 2007 and December 2017 were retrospectively collected and analyzed. Read More

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http://dx.doi.org/10.1155/2019/4913814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431487PMC
March 2019
1 Read

Uropathogens and their antimicrobial resistance patterns: Relationship with urinary tract infections.

Int J Health Sci (Qassim) 2019 Mar-Apr;13(2):48-55

Department of Pathology and Laboratory Medicine, College of Medicine, Qassim University, Saudi Arabia.

Objectives: This study was performed to determine the prevalence of uropathogens causing urinary tract infections (UTIs) and to determine their pattern of antimicrobial resistance.

Methods: This study was conducted on 273 urine samples collected from outpatient departments (OPDs) of Qassim University affiliated hospitals. Fully automated VITEK 2 compact system was used in the identification and antimicrobial susceptibility testing of causative microorganisms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436442PMC

Protection against Pseudomonas plecoglossicida in Epinephelus coioides immunized with a cspA1-knock-down live attenuated vaccine.

Fish Shellfish Immunol 2019 Apr 11;89:498-504. Epub 2019 Apr 11.

Fisheries College, Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture, Jimei University, Xiamen, Fujian, PR China. Electronic address:

Pseudomonas plecoglossicida is well-known as the cause of viscera granulomas disease in fish. In this study, a cspA1 knock-down strain was constructed and tested in Epinephelus coioides to observe the changes in virulence and evaluate its potential as an attenuated live vaccine. The results showed that the cspA1 knock-down strain caused a significant reduction in the ability of biofilm formation, motility, adhesion and virulence. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.029DOI Listing

In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration.

J Control Release 2019 Apr 11;303:24-33. Epub 2019 Apr 11.

INSERM, Centre d'Etude des Pathologies Respiratoires, U1100, F-37032 Tours, France; Université de Tours, F-37032 Tours, France. Electronic address:

Due to growing antibiotic resistance, pneumonia caused by Pseudomonas aeruginosa is a major threat to human health and is driving the development of novel anti-infectious agents. Preventively or curatively administered pathogen-specific therapeutic antibodies (Abs) have several advantages, including a low level of toxicity and a unique pharmacological profile. At present, most Abs against respiratory infections are administered parenterally; this may not be optimal for therapeutics that have to reach the lungs to be effective. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.005DOI Listing
April 2019
2 Reads

Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa.

Microb Pathog 2019 Apr 10;131:186-196. Epub 2019 Apr 10.

Department of Microbiology and Immunology, University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221, Belgrade, Serbia. Electronic address:

Acinetobacter baumannii and Pseudomonas aeruginosa are frequent multiresistant nosocomial pathogens that cause wound and pulmonary infections in hospitalized patients. As being increasingly resistant to most clinically available antibiotics, there is a constant need for exploration of new substances that could kill them or inhibit their growth, or alternatively inhibit some of their essential virulence factors. Chalcones are chemical compounds with well-documented antimicrobial potential. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.015DOI Listing

Can Nebulised Colistin Therapy Improve Outcomes in Critically Ill Children with Multi-Drug Resistant Gram-Negative Bacterial Pneumonia?

Antibiotics (Basel) 2019 Apr 11;8(2). Epub 2019 Apr 11.

Department of Pediatric Intensive Care Unit, Istanbul University Cerrahpasa Medical Faculty, 34098 Fatih, Istanbul, Turkey.

In the past decade, multidrug-resistant (MDR) gram-negative bacteria have become a major problem, especially for patients in intensive care units. Recently, colistin became the last resort therapy for MDR gram-negative bacteria infections. However, nebulised colistin use was limited to adult patients. Read More

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http://dx.doi.org/10.3390/antibiotics8020040DOI Listing
April 2019
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1,4-Naphthoquinone Analogues: Potent Antibacterial Agents and Mode of Action Evaluation.

Molecules 2019 Apr 11;24(7). Epub 2019 Apr 11.

Department of Life Science, Department of Energy Storage/Conversion Engineering of Graduate School, and Hydrogen and Fuel Cell Research Center, Chonbuk National University, Jeollabuk-do 54896, Korea.

1,4-Naphthoquinones have antibacterial activity and are a promising new class of compound that can be used to treat bacterial infections. The goal was to improve effective antibacterial agents; therefore, we synthesized a new class of naphthoquinone hybrids, which contain phenylamino-phenylthio moieties as significant counterparts. Compound was modified as a substituted aryl amide moiety, which enhanced the antibacterial activity of earlier compounds and . Read More

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https://www.mdpi.com/1420-3049/24/7/1437
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http://dx.doi.org/10.3390/molecules24071437DOI Listing
April 2019
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A Nanocomposite Based on Reduced Graphene and Gold Nanoparticles for Highly Sensitive Electrochemical Detection of through Its Virulence Factors.

Materials (Basel) 2019 Apr 11;12(7). Epub 2019 Apr 11.

Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Haţieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania.

Pyoverdine is a fluorescent siderophore produced by that can be considered as a detectable marker in nosocomial infections. The presence of pyoverdine in water can be directly linked to the presence of the , thus being a nontoxic and low-cost marker for the detection of biological contamination. A novel platform was developed and applied for the electrochemical selective and sensitive detection of pyoverdine, based on a graphene/graphite-modified screen-printed electrode (SPE) that was electrochemically reduced and decorated with gold nanoparticles (NPs). Read More

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http://dx.doi.org/10.3390/ma12071180DOI Listing

Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa.

PLoS Pathog 2019 Apr 12;15(4):e1007694. Epub 2019 Apr 12.

Centre for Inflammation Research at the University of Edinburgh, Queens' Medical Research Institute, Edinburgh BioQuarter, Little France Crescent, Edinburgh, United Kingdom.

Pulmonary infections are a major global cause of morbidity, exacerbated by an increasing threat from antibiotic-resistant pathogens. In this context, therapeutic interventions aimed at protectively modulating host responses, to enhance defence against infection, take on ever greater significance. Pseudomonas aeruginosa is an important multidrug-resistant, opportunistic respiratory pathogen, the clearance of which can be enhanced in vivo by the innate immune modulatory properties of antimicrobial host defence peptides from the cathelicidin family, including human LL-37. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007694
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http://dx.doi.org/10.1371/journal.ppat.1007694DOI Listing
April 2019
2 Reads

Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.

Cell Physiol Biochem 2019 ;52(5):1092-1102

Department of Molecular Biology, Medical School, University of Duisburg-Essen, Essen, Germany,

Background/aims: Recent studies indicated that an inhalation treatment of cystic fibrosis mice with acid ceramidase prevents and eliminates infections with Pseudomonas aeruginosa and Stapyhlococcus aureus. Inhalation of acid ceramidase facilitated the elimination of P. aeruginosa in acutely- or chronically-infected mice with cystic fibrosis. Read More

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http://dx.doi.org/10.33594/000000074DOI Listing
January 2019
1 Read

Epidemiological and clinical features of prosthetic joint infections caused by gram-negative bacteria.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):187-194

Fondazione Policlinico A. Gemelli IRCCS - Rome, Italy.

Objective: To review the clinical literature focusing on epidemiology, clinical presentation and outcomes of prosthetic joint infections (PJIs) due to gram-negative bacteria (GNB) and to report the experience of a multicentric cohort.

Patients And Methods: A retrospective, observational, cohort study was performed in three Italian hospitals. All consecutive PJIs caused by GNB over a 12-year period (from May 2007 to March 2018) were enrolled. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17490DOI Listing

Do liquid wastes from automated instruments in medical laboratories have their proper microbicide effect?

Ann Biol Clin (Paris) 2019 Apr 12. Epub 2019 Apr 12.

Laboratoire de virologie, Institut des agents infectieux, Groupement Hospitalier Nord des Hospices civils de Lyon, Lyon, France, Institut des sciences biologiques et pharmaceutiques de Lyon, Université Claude Bernard Lyon 1, Lyon, France, CIRI, Centre international de recherche en infectiologie, Équipe Virpath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École normale supérieure de Lyon, Lyon, France.

Liquid wastes from clinical biology automated systems are currently evacuated in the urban network after chemical treatment to eliminate a possible risk of infection. Since these wastes are ecotoxic because of the presence of numerous chemical reagents, we studied their intrinsic microbicidal power towards a selection of infectious agents widely found in clinical specimens. The objective was to determine if an additional anti-infectious treatment before elimination is necessary. Read More

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http://dx.doi.org/10.1684/abc.2019.1431DOI Listing
April 2019
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Shifting trends and age distribution of ESKAPEEc resistance in bloodstream infection, Southwest China, 2012-2017.

Antimicrob Resist Infect Control 2019 29;8:61. Epub 2019 Mar 29.

1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Yuzhong District, Chongqing, 400016 People's Republic of China.

Background: ESKAPEEc contribute to a majority of bloodstream infections (BSIs) and their antibiogram have changed overtime, while data concerning about these alterations are lacking in China. Added that a paucity of studies referred to ESKAPEEc in pediatric BSIs, our study aimed to demonstrate the longitudinal alterations of ESKAPEEc distribution and antibiogram in adult and pediatric BSIs in Southwest China.

Methods: A multicenter retrospective surveillance study was launched from 2012 to 2017. Read More

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http://dx.doi.org/10.1186/s13756-019-0499-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441235PMC
March 2019
1 Read

Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in plants.

Science 2019 04;364(6436):178-181

Chair of Phytopathology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising-Weihenstephan, Germany.

In plants, cell-surface immune receptors sense molecular non-self-signatures. Lipid A of Gram-negative bacterial lipopolysaccharide is considered such a non-self-signature. The receptor kinase LIPOOLIGOSACCHARIDE-SPECIFIC REDUCED ELICITATION (LORE) mediates plant immune responses to and but not enterobacterial lipid A or lipopolysaccharide preparations. Read More

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http://dx.doi.org/10.1126/science.aau1279DOI Listing
April 2019
10 Reads

Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Department of Oral Biology, Rady Faculty of Health Sciences, University of Manitoba, 780 Bannatyne Ave, Winnipeg, MB R3E 0J9, Canada.

Gram-negative pathogens such as , , and are the leading cause of nosocomial infections throughout the world. One commonality shared among these pathogens is their ubiquitous presence, robust host-colonization and most importantly, resistance to antibiotics. A significant number of two-component systems (TCSs) exist in these pathogens, which are involved in regulation of gene expression in response to environmental signals such as antibiotic exposure. Read More

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https://www.mdpi.com/1422-0067/20/7/1781
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http://dx.doi.org/10.3390/ijms20071781DOI Listing
April 2019
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The Clinical Features of Bronchiectasis Associated with Alpha-1 Antitrypsin Deficiency, Common Variable Immunodeficiency and Primary Ciliary Dyskinesia--Results from the U.S. Bronchiectasis Research Registry.

Chronic Obstr Pulm Dis 2019 Apr 9;6(2). Epub 2019 Apr 9.

Oregon Health Sciences University Hospital, Portland.

Objective: This study compares and contrasts the clinical features of non-cystic fibrosis bronchiectasis with 3 uncommon disorders known to be associated with bronchiectasis but with distinctly different underlying defined pathophysiologic derangements, namely severe alpha-1 antitrypsin deficiency (AATD), common variable immunodeficiency (CVI) and primary ciliary dyskinesia (PCD).

Methods: The Bronchiectasis Research Registry provides a central database for studying patients with non-cystic fibrosis bronchiectasis. This report consists of information from 13 U. Read More

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http://dx.doi.org/10.15326/jcopdf.6.2.2018.0156DOI Listing
April 2019
7 Reads

New Drugs for Multidrug-Resistant Gram-Negative Organisms: Time for Stewardship.

Drugs 2019 Apr 10. Epub 2019 Apr 10.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, 100, Taiwan.

A gradual rise in drug-resistant trends among Gram-negative organisms, especially carbapenem-resistant (CR) Enterobacteriaceae (CRE), CR-Pseudomonas aeruginosa, and extensively-drug-resistant (XDR) Acinetobacter baumannii, poses an enormous threat to healthcare systems worldwide. In the last decade, many pharmaceutical companies have devoted enormous resources to the development of new potent antibiotics against XDR Gram-negative pathogens, particularly CRE. Some of these novel antibiotics against CRE strains are β-lactam/β-lactamase-inhibitor combination agents, while others belong to the non-β-lactam class. Read More

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http://dx.doi.org/10.1007/s40265-019-01112-1DOI Listing

Adaptation of Pseudomonas aeruginosa clinical isolates to benzalkonium chloride retards its growth and enhances biofilm production.

Mol Biol Rep 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical Campus, Tanta University, El-Geish Street, Tanta, El-Gharbia, 31611, Egypt.

The increasing percentage of Pseudomonas aeruginosa strains that are resistant to multiple antibiotics is a global problem. The exposure of P. aeruginosa isolates to repeated sub lethal concentrations of biocides in hospitals and communities may be one of the causes leading to increased antibiotic resistance. Read More

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http://dx.doi.org/10.1007/s11033-019-04806-7DOI Listing

Virulence factors and integrons are associated with MDR and XDR phenotypes in nosocomial strains of Pseudomonas aeruginosa in a Venezuelan university hospital.

Rev Inst Med Trop Sao Paulo 2019 4;61:e20. Epub 2019 Apr 4.

Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Queretaro, Mexico.

Multidrug resistance (MDR), virulence and transferable elements potentiate Pseudomonas aeruginosa's role as an opportunistic pathogen creating a high risk for public health. In this study, we evaluated the possible association of multidrug resistance, virulence factors and integrons with intrahospital P. aeruginosa strains isolated from patients at Cumana hospital, Venezuela. Read More

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http://dx.doi.org/10.1590/S1678-9946201961020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453424PMC
April 2019
1 Read

Fecal Microbiota Transplantation Decreases Intestinal Loads of Multi-Drug Resistant in Murine Carriers.

Eur J Microbiol Immunol (Bp) 2019 Mar 4;9(1):14-22. Epub 2019 Mar 4.

Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Intestinal carriage of multi-drug resistant (MDR) Gram-negative bacteria including (Psae) constitutes a pivotal prerequisite for subsequent fatal endogenous infections in patients at risk. We here addressed whether fecal microbiota transplantation (FMT) could effectively combat MDR-Psae carriage. Therefore, secondary abiotic mice were challenged with MDR-Psae by gavage. Read More

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http://dx.doi.org/10.1556/1886.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444800PMC

Social Behavior of Antibiotic Resistant Mutants Within Biofilm Communities.

Front Microbiol 2019 22;10:570. Epub 2019 Mar 22.

Servicio de Microbiología, Hospital Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.

The complex spatial structure and the heterogeneity within biofilms lead to the emergence of specific social behaviors. However, the impact of resistant mutants within bacterial communities is still mostly unknown. Thus, we determined whether antibiotic resistant mutants display selfish or altruistic behaviors in mixed biofilms exposed to antibiotics. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438888PMC

Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α4-Short, in a Murine Model of Respiratory Infection.

MBio 2019 Apr 9;10(2). Epub 2019 Apr 9.

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Multidrug resistance (MDR) by bacterial pathogens constitutes a global health crisis, and resistance to treatment displayed by biofilm-associated infections (e.g., cystic fibrosis, surgical sites, and medical implants) only exacerbates a problem that is already difficult to overcome. Read More

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http://dx.doi.org/10.1128/mBio.00226-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456746PMC
April 2019
2 Reads

Ferulic acid encapsulated chitosan-tripolyphosphate nanoparticles attenuate quorum sensing regulated virulence and biofilm formation in PAO1.

IET Nanobiotechnol 2018 Dec;12(8):1056-1061

Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry-605 014, India.

is an opportunistic nosocomial pathogenic microorganism causing majority of acute hospital-acquired infections and poses a serious public health concern. The persistence of bacterial infection can be attributed to the highly synchronised cell-to-cell communication phenomenon, quorum sensing (QS) which regulates the expression of a number of virulence factors and biofilm formation which eventually imparts resistance to the conventional antimicrobial therapy. In this study, the anti-quorum sensing and anti-biofilm potential of ferulic acid encapsulated chitosan-tripolyphosphate nanoparticles (FANPs) was investigated against PAO1 and compared with native ferulic acid. Read More

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http://dx.doi.org/10.1049/iet-nbt.2018.5114DOI Listing
December 2018

Role of antioxidant molecules and polymers in prevention of bacterial growth and biofilm formation.

Curr Med Chem 2019 Apr 9. Epub 2019 Apr 9.

Department of Chemistry, Sapienza University of Rome. Italy.

Background: Antioxidants are multifaceted molecules playing a crucial role in several cellular functions. There is by now a well-established knowledge about their involvement in numerous processes associated with aging, including vascular damage, neurodegenerative diseases and cancer. An emerging area of application has been lately identified for these compounds in relation to the recent findings indicating their ability to affect biofilm formation by some microbial pathogens, including Staphylococcus aureus, Streptococcus mutans, and Pseudomonas aeruginosa. Read More

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http://www.eurekaselect.com/171477/article
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http://dx.doi.org/10.2174/0929867326666190409120409DOI Listing
April 2019
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Different bacterial and viral pathogens trigger distinct immune responses in a globally invasive ant.

Sci Rep 2019 Apr 8;9(1):5780. Epub 2019 Apr 8.

School of Mathematics and Statistics, Victoria University of Wellington, PO Box 600, Wellington, 6012, New Zealand.

Invasive species populations periodically collapse from high to low abundance, sometimes even to extinction. Pathogens and the burden they place on invader immune systems have been hypothesised as a mechanism for these collapses. We examined the association of the bacterial pathogen (Pseudomonas spp. Read More

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http://dx.doi.org/10.1038/s41598-019-41843-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453929PMC

Population Pharmacokinetics and dosing optimisation of Imipenem in Children with haematological malignancies.

Antimicrob Agents Chemother 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical Pharmacy, School of PharmaceuticalSciences, Shandong University, Jinan, China

Imipenem is widely used for the treatment of children with serious infections. Currently, there is lack of pharmacokinetic studies of imipenem in children with hematological malignancies. Given the significant impact of disease on pharmacokinetics and increased resistance, we aimed to conduct a population based pharmacokinetic study of imipenem and optimize the dosage regimens for this vulnerable population. Read More

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http://dx.doi.org/10.1128/AAC.00006-19DOI Listing
April 2019
3 Reads
4.476 Impact Factor

Multidrug-resistant Pseudomonas aeruginosa and mortality inmechanically ventilated ICU patients.

Am J Infect Control 2019 Apr 6. Epub 2019 Apr 6.

Assistance Publique - Hôpitaux de Marseille, Hôpital Nord, Réanimation des Détresses Respiratoires et des Infections Sévères, Marseille, France; Aix-Marseille Université, School of Medicine - La Timone Medical Campus, CEReSS - Health Service Research and Quality of Life Center, Marseille, France.

Background: The link between bacterial resistance and prognosis remains controversial. Predominant pathogen causing ventilator-associated pneumonia (VAP) is Pseudomonas aeruginosa (Pa), which has increasingly become multidrug resistant (MDR). The aim of this study was to evaluate the relationship between MDR VAP Pa episodes and 30-day mortality. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.02.030DOI Listing
April 2019
3 Reads

Endoscope reprocessing: Comparison of drying effectiveness and microbial levels with an automated drying and storage cabinet with forced filtered air and a standard storage cabinet.

Am J Infect Control 2019 Apr 6. Epub 2019 Apr 6.

Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address:

Background: Automated drying may help prevent endoscopically transmitted infections. We aimed to assess the efficacy of an automated drying and storage cabinet compared to a standard storage cabinet in achieving endoscope dryness postreprocessing and in reducing the risk of microbial growth.

Methods: Drying times of bronchoscopes, colonoscopes, and duodenoscopes using 2 drying platforms (an automated drying and storage cabinet vs a standard storage cabinet) were measured using cobalt chloride paper. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01966553193010
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http://dx.doi.org/10.1016/j.ajic.2019.02.016DOI Listing
April 2019
1 Read

Detection of in the Skin by Immunomagnetic Isolation and Real-Time Quantitative PCR.

J Nanosci Nanotechnol 2019 Sep;19(9):5517-5521

Chinese Tradition Department, Guangzhou Institute of Dermatology, Guangzhou 510095, China.

() causes a broad spectrum of skin infections and early treatment with antibiotics is critical for successful therapy. Currently, is detected by time-consuming culturing and counting the bacteria. Therefore, the goal of the present study was to design a rapid, sensitive, and specific protocol for the identification of infection in the skin. Read More

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https://www.ingentaconnect.com/content/10.1166/jnn.2019.1659
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http://dx.doi.org/10.1166/jnn.2019.16595DOI Listing
September 2019
4 Reads