41,728 results match your criteria Pseudomonas Aeruginosa Infections

Antimicrobial Peptides against Multidrug-Resistant Biofilm from Cystic Fibrosis Patients.

J Med Chem 2022 Jun 27. Epub 2022 Jun 27.

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.

Lung infection is the leading cause of morbidity and mortality in cystic fibrosis (CF) patients and is mainly dominated by . Treatment of CF-associated lung infections is problematic because the drugs are vulnerable to multidrug-resistant pathogens, many of which are major biofilm producers like . Antimicrobial peptides (AMPs) are essential components in all life forms and exhibit antimicrobial activity. Read More

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Assessment of disinfectant efficacy in reducing microbial growth.

PLoS One 2022 27;17(6):e0269850. Epub 2022 Jun 27.

Reference Laboratory for Microbiology, Executive Department of Reference Laboratories, Research and Laboratories Sector, Saudi Food and Drug Authority (SFDA), Riyadh, Saudi Arabia.

The incidence of hospital- and community-acquired infections has been dramatically increased worldwide. Accordingly, hands hygiene and the use of disinfectants have been increased leading to the expansion in hand sanitizers production to meet public demand. This study was conducted to assess the efficiency of common disinfectants in the market of Riyadh, Saudi Arabia in inhibiting the microbial growth during the time of Coronavirus disease 2019 (COVID-19) pandemic. Read More

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Feasibility of 16S rRNA sequencing for cerebrospinal fluid microbiome analysis in cattle with neurological disorders: a pilot study.

Vet Res Commun 2022 Jun 27. Epub 2022 Jun 27.

Department of Veterinary Sciences, Clinical section, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, TO, Italy.

Bacterial infection of the central nervous system (CNS) in cattle requires prompt and adequate antimicrobial treatment. The current gold standard for antemortem etiological diagnosis is cerebrospinal fluid (CSF) culture, which often yields false negative results. CSF has long been considered a sterile district in healthy patients, but this notion has been recently challenged. Read More

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Enterococcus faecalis Antagonizes Pseudomonas aeruginosa Growth in Mixed-Species Interactions.

J Bacteriol 2022 Jun 27:e0061521. Epub 2022 Jun 27.

Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological Universitygrid.59025.3b, Singapore.

Enterococcus faecalis is often coisolated with Pseudomonas aeruginosa in polymicrobial biofilm-associated infections of wounds and the urinary tract. As a defense strategy, the host innately restricts iron availability at infection sites. Despite their coprevalence, the polymicrobial interactions of these two species in biofilms and under iron-restricted conditions remain unexplored. Read More

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Activity of Cefiderocol against Extensively Drug-Resistant Pseudomonas aeruginosa: CANWARD, 2007 to 2019.

Microbiol Spectr 2022 Jun 27:e0172422. Epub 2022 Jun 27.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitobagrid.21613.37, Winnipeg, Manitoba, Canada.

Cefiderocol was evaluated by broth microdilution versus 1,050 highly antimicrobial-resistant Pseudomonas aeruginosa clinical isolates from the CANWARD study (2007 to 2019). Overall, 98.3% of isolates remained cefiderocol susceptible (MIC, ≤4 μg/mL), including 97. Read More

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A review on the mechanistic details of OXA enzymes of ESKAPE pathogens.

Pathog Glob Health 2022 Jun 26:1-16. Epub 2022 Jun 26.

Bioengineering Department, Marmara University, Kadikoy, 34722, Turkey.

The production of β-lactamases is a prevalent mechanism that poses serious pressure on the control of bacterial resistance. Furthermore, the unavoidable and alarming increase in the transmission of bacteria producing extended-spectrum β-lactamases complicates treatment alternatives with existing drugs and/or approaches. Class D β-lactamases, designated as OXA enzymes, are characterized by their activity specifically towards oxacillins. Read More

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Chemotaxonomy and Antibacterial Activity of the Extracts and Chemical Constituents of Hiern. (Rubiaceae).

Biomed Res Int 2022 15;2022:7856305. Epub 2022 Jun 15.

Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.

The use of natural products for medicinal purposes is becoming more and more common nowadays, as evidenced by the presence in plants of secondary metabolites with different potentials such as antioxidant and antibacterial properties. We evaluated in this work the antimicrobial activities of the extracts and some isolated compounds from the seeds of Hiern. (Rubiaceae), a Cameroonian medicinal plant traditionally used to cure microbial infections. Read More

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Antimicrobial peptide S100A12 (calgranulin C) inhibits growth, biofilm formation, pyoverdine secretion and suppresses type VI secretion system in Pseudomonas aeruginosa.

Microb Pathog 2022 Jun 23:105654. Epub 2022 Jun 23.

Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India. Electronic address:

Pseudomonas aeruginosa is an opportunistic pathogen and is the major cause of corneal infections in India and worldwide. The increase in antimicrobial resistance among Pseudomonas has prompted rise in significant research to develop alternative therapeutics. Antimicrobial peptides (AMPs) are considered as potent alternatives to combat bacterial infections. Read More

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Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics.

Signal Transduct Target Ther 2022 Jun 25;7(1):199. Epub 2022 Jun 25.

Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive pulmonary disorder (COPD), cancer, and severe infection requiring ventilation, such as COVID-19. P. Read More

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Colistimethate sodium-chitosan hydrogel for treating Gram-negative bacterial wound infections.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi 682041, India. Electronic address:

The drug resistance is higher among Gram-negative bacteria and demands the usage of strong antibiotics which can in turn result in systemic toxicity. In the treatment of the chronic wounds harboring pathogenic Gram-negative bacteria, the demand for an antimicrobial product that can be topically administered has been on the rise. In an effort to address the above issue, we have developed Colistimethate sodium (a high-end antibiotic) loaded chitosan hydrogel and characterized. Read More

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Insilico structure based drug design approach to find potential hits in ventilator-associated pneumonia caused by Pseudomonas aeruginosa.

Comput Biol Med 2022 Jul 18;146:105597. Epub 2022 May 18.

Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Baugh, Aurangabad, MS, India. Electronic address:

Tetraacyldisaccharide 4'-kinase (LpxK) is the prime enzyme responsible for the biosynthesis of lipid A. LpxK is a key antibacterial drug target, but it is less exploitation in Pseudomonas aeruginosa and other bacterial species limits its therapeutic use. Pseudomonas aeruginosa is responsible for severe infections like pneumonia and urinary tract infections. Read More

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Silver-doped phosphate coacervates to inhibit pathogenic bacteria associated with wound infections: an in vitro study.

Sci Rep 2022 Jun 24;12(1):10778. Epub 2022 Jun 24.

Department of Chemistry, University of Surrey, Guildford, GU27XH, UK.

There is a great demand from patients requiring skin repair, as a result of poorly healed acute wounds or chronic wounds. These patients are at high risk of constant inflammation that often leads to life-threatening infections. Therefore, there is an urgent need for new materials that could rapidly stimulate the healing process and simultaneously prevent infections. Read More

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Mannose-Binding Lectin (MBL) and Gap Junction Protein Alpha 4 (GJA4) Gene Heterogeneity in Relation to Severity of Clinical Disease in Cystic Fibrosis.

Front Biosci (Landmark Ed) 2022 May;27(6):168

University Children's Hospital Bonn, 53127 Bonn, Germany.

Background: Recently, we provided evidence that a single nucleotide polymorphism (SNP), rs41266431, on the gap junction protein alpha 4 (GJA4) gene, acts as a modifier for clinical disease severity in patients with cystic fibrosis (CF). These features are very similar to those of variants of the mannose-binding lectin (MBL). This study aimed to clarify whether the clinical disease phenotype associated with GJA4 variants is independent of MBL variants. Read More

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Bacterial Ghosts of as a Promising Candidate Vaccine and Its Application in Diabetic Rats.

Vaccines (Basel) 2022 Jun 7;10(6). Epub 2022 Jun 7.

Department of Microbiology and Immunology, Faculty of Pharmacy, Alexandria University, Alexandria 21568, Egypt.

Infections with   (PA) pose a major clinical threat worldwide especially to immunocompromised patients. As a novel vaccine network for many kinds of bacteria, bacterial ghosts (BGs) have recently been introduced. In the present research, using Sponge-Like Reduced Protocol ghosts (PAGs) were prepared to maintain surface antigens and immunogenicity. Read More

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Biosensors for with Molecularly Imprinted Polymer (MIP) Technique.

Sensors (Basel) 2022 Jun 20;22(12). Epub 2022 Jun 20.

Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

Nosocomial infection is one of the most important problems that occurs in hospitals, as it directly affects susceptible patients or patients with immune deficiency. ( is the most common cause of nosocomial infections in hospitals. can cause various diseases such as pneumonia, urinary tract infections, septicemias, and soft tissue infections, and it has also become highly resistant to antibiotics. Read More

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Integrating In Vitro and In Silico Analysis of a Cationic Antimicrobial Peptide Interaction with Model Membranes of Colistin-Resistant Strains.

Pharmaceutics 2022 Jun 12;14(6). Epub 2022 Jun 12.

Research Group of Chemistry and Biotechnology, Faculty of Basic Sciences, Universidad Santiago of Cali, Cali 760035, Colombia.

Bacterial antibiotic resistance is a serious global public health concern. Infections caused by colistin-resistant (CRPa) strains represent a serious threat due to their considerable morbidity and mortality rates, since most of the current empirical antibiotic therapies are ineffective against these strains. Accordingly, cationic antimicrobial peptides (CAMPs) have emerged as promising alternatives to control resistant bacteria. Read More

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Individualized, Additively Manufactured Drug-Releasing External Ear Canal Implant for Prevention of Postoperative Restenosis: Development, In Vitro Testing, and Proof of Concept in an Individual Curative Trial.

Pharmaceutics 2022 Jun 11;14(6). Epub 2022 Jun 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), Hannover Medical School, Stadtfelddamm 34, 30625 Hannover, Germany.

Postoperative restenosis in patients with external ear canal (EEC) atresia or stenosis is a common complication following canaloplasty. Our aim in this study was to explore the feasibility of using a three dimensionally (3D)-printed, patient-individualized, drug ((dexamethasone (DEX)), and ciprofloxacin (cipro))-releasing external ear canal implant (EECI) as a postoperative stent after canaloplasty. We designed and pre-clinically tested this novel implant for drug release (by high-performance liquid chromatography), biocompatibility (by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay), bio-efficacy (by the TNF-α (tumor necrosis factor-alpha)-reduction test (DEX) and inhibition zone test (for cipro)), and microbial contamination (formation of turbidity or sediments in culture medium). Read More

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Probability of Target Attainment of Tobramycin Treatment in Acute and Chronic Lung Infection Based on Preclinical Population Pharmacokinetic Modeling.

Pharmaceutics 2022 Jun 11;14(6). Epub 2022 Jun 11.

Pharmaceutical Sciences Graduate Program, Federal University of Rio Grande do Sul-UFRGS, Porto Alegre 90610-000, Brazil.

Biofilms and infectious process may alter free antimicrobial concentrations at the site of infection. Tobramycin (TOB), an aminoglycoside used to treat lung infections caused by , binds to alginate present in biofilm extracellular matrix increasing its minimum inhibitory concentration (MIC). This work aimed to investigate the impact of biofilm-forming infection on TOB lung and epithelial lining fluid (ELF) penetration, using microdialysis, and to develop a population pharmacokinetic (popPK) model to evaluate the probability of therapeutic target attainment of current dosing regimens employed in fibrocystic and non-fibrocystic patients. Read More

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In-Vitro Antibacterial Activity of Curcumin-Loaded Nanofibers Based on Hyaluronic Acid against Multidrug-Resistant ESKAPE Pathogens.

Pharmaceutics 2022 May 31;14(6). Epub 2022 May 31.

Saint-Petersburg Pasteur Institute, Street Mira, 14, 197101 St. Petersburg, Russia.

Bacterial infections have accompanied humanity throughout its history and became vitally important in the pandemic area. The most pathogenic bacteria are multidrug-resistant strains, which have become widespread due to their natural biological response to the use of antibiotics, including uncontrolled use. The current challenge is finding highly effective antibacterial agents of natural origin, which, however, have low solubility and consequently poor bioavailability. Read More

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Microbiological, Clinical and Radiological Aspects of Diabetic Foot Ulcers Infected with Methicillin-Resistant and -Sensitive .

Pathogens 2022 Jun 17;11(6). Epub 2022 Jun 17.

2nd Division of Radiology, Medical Faculty, Medical University of Gdansk, 80-214 Gdansk, Poland.

Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study aimed to assess the factors with an impact on the infection of diabetic foot ulcers by methicillin-resistant and to evaluate the influence of methicillin resistance on the frequency of osteitis (based on classic X-ray images). A total of 863 patients suffering from DFU were analyzed during the study period. Read More

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Infections in Cancer Patients.

Pathogens 2022 Jun 12;11(6). Epub 2022 Jun 12.

Department of Microbiology and Immunology, Institute of Medical Science, Collegium Medicum, Jan Kochanowski University, IX Wieków Kielc 19A, 25-317 Kielce, Poland.

() is one of the most frequent opportunistic microorganisms causing infections in oncological patients, especially those with neutropenia. Through its ability to adapt to difficult environmental conditions and high intrinsic resistance to antibiotics, it successfully adapts and survives in the hospital environment, causing sporadic infections and outbreaks. It produces a variety of virulence factors that damage host cells, evade host immune responses, and permit colonization and infections of hospitalized patients, who usually develop blood stream, respiratory, urinary tract and skin infections. Read More

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Recent Advances in the Use of Molecular Methods for the Diagnosis of Bacterial Infections.

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Department of Human Pathology, University of Messina, 98125 Messina, Italy.

Infections caused by bacteria have a major impact on public health-related morbidity and mortality. Despite major advances in the prevention and treatment of bacterial infections, the latter continue to represent a significant economic and social burden worldwide. The WHO compiled a list of six highly virulent multidrug-resistant bacteria named ESKAPE (, , , , , and species) responsible for life-threatening diseases. Read More

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Surveillance of Amoebic Keratitis-Causing Acanthamoebae for Potential Bacterial Endosymbionts in Ontario, Canada.

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Tropical Disease Unit, Division of Infectious Diseases, UHN-Toronto General Hospital, Toronto, ON M5G 2C4, Canada.

spp. are the causative pathogens of several infections, including amoebic keratitis (AK), a vision-threatening infection. Acanthamoebae from corneal specimens of patients with AK harbor bacterial endosymbionts, which may increase virulence. Read More

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The Ability of Nuclease-Resistant RNA Aptamer against Serotype 2, Strain P1/7 to Reduce Biofilm Formation In Vitro.

Molecules 2022 Jun 17;27(12). Epub 2022 Jun 17.

Division of Clinical Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

, a Gram-positive bacterium, is an important swine and human pathogen, with serotype 2 being the most prevalent strain found worldwide. Deafness, meningitis, and death (in severe cases) are observed in -infected cases. Development of the ligands that can bind to with high affinity and specificity could be beneficial for the diagnosis and treatment of infection. Read More

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Resistance Is Not Futile: The Role of Quorum Sensing Plasticity in Infections and Its Link to Intrinsic Mechanisms of Antibiotic Resistance.

Microorganisms 2022 Jun 18;10(6). Epub 2022 Jun 18.

Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY 12201, USA.

Bacteria use a cell-cell communication process called quorum sensing (QS) to orchestrate collective behaviors. QS relies on the group-wide detection of extracellular signal molecules called autoinducers (AI). Quorum sensing is required for virulence and biofilm formation in the human pathogen . Read More

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Enhanced Antibiotic Tolerance of an Multispecies Uropathogen Biofilm Model, Useful for Studies of Catheter-Associated Urinary Tract Infections.

Microorganisms 2022 Jun 13;10(6). Epub 2022 Jun 13.

Section of Microbiology, Department of Biology, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark.

Catheter-associated urinary tract infections (CAUTI) are a common clinical concern as they can lead to severe, persistent infections or bacteremia in long-term catheterized patients. This type of CAUTI is difficult to eradicate, as they are caused by multispecies biofilms that may have reduced susceptibility to antibiotics. Many new strategies to tackle CAUTI have been proposed in the past decade, including antibiotic combination treatments, surface modification and probiotic usage. Read More

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Targeting Persistent Biofilm Infections: Reconsidering the Topography of the Infection Site during Model Selection.

Microorganisms 2022 Jun 6;10(6). Epub 2022 Jun 6.

Department of Endodontics, Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

The physiology of an organism in the environment reflects its interactions with the diverse physical, chemical, and biological properties of the surface. These principles come into consideration during model selection to study biofilm-host interactions. Biofilms are communities formed by beneficial and pathogenic bacteria, where cells are held together by a structured extracellular matrix. Read More

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Comparative Evaluation of Antimicrobial, Antiamoebic, and Antiviral Efficacy of Ophthalmic Formulations.

Microorganisms 2022 Jun 4;10(6). Epub 2022 Jun 4.

Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.

The extensive use of ophthalmic antibiotics is contributing to the appearance of resistant bacterial strains, which require prolonged and massive treatments with consequent detrimental outcomes and adverse effects. In addition to these issues, antibiotics are not effective against parasites and viruses. In this context, antiseptics could be valuable alternatives. Read More

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Long-Term Impact of the COVID-19 Pandemic on In-Hospital Antibiotic Consumption and Antibiotic Resistance: A Time Series Analysis (2015-2021).

Antibiotics (Basel) 2022 Jun 20;11(6). Epub 2022 Jun 20.

Clinic of Infectious Diseases, Department of Infectious Diseases, University of Modena, 41124 Modena, Italy.

The coronavirus disease 2019 (COVID-19)-pandemic-related overload of health systems has compromised the application of antimicrobial stewardship (AS) models and infection prevention and control (IPC) programs. We aimed to evaluate the impact of COVID-19 on antimicrobial consumption (AC) and antimicrobial resistance (AMR) in the University Hospital of Modena. A time series analysis with an autoregressive integrated moving average model was conducted from January 2015 to October 2021 to evaluate the AC in the whole hospital and the intensive care unit (ICU), the incidence density (ID) of bloodstream infections (BSIs) due to the main multidrug-resistant organisms, and of infections (CDIs). Read More

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Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen.

Antibiotics (Basel) 2022 Jun 14;11(6). Epub 2022 Jun 14.

Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai 200040, China.

Colistin methanesulfonate (CMS) is an important treatment option for infections caused by carbapenem-resistant Gram-negative organisms (CROs). This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) profiles and safety of CMS in Chinese subjects following a recommended dosage. A total of 12 healthy Chinese subjects received CMS injections at 2. Read More

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