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Abdom Radiol (NY) 2022 04 23;47(4):1298-1310. Epub 2022 Feb 23.

Department of Internal Medicine, Pratumtani Hospital, 7 Ladlumkaew Muang district, Pratumtani, 12000, Thailand.

The use of diverse types of drugs can result in a variety of acute and chronic complications that affect almost any organ. The bowel is one of the organs impacted by the side effects of medications. Imaging frequently plays a crucial role in the detection and characterization of complications occurring in the bowel. Read More

J Gastrointestin Liver Dis 2021 12 21;30(4):506-516. Epub 2021 Dec 21.

Iuliu Hatieganu University of Medicine and Pharmacy, Faculty of Medicine, Internal Medicine Department, Cluj- Napoca; Clinical Municipal Hospital, Cluj-Napoca, Romania.

Background And Aims: While immune checkpoint inhibitors therapy (ICI) is exceedingly effective, these drugs are associated with various immune-related adverse effects. As gastrointestinal, hepatic or pancreatic toxicity becomes more common, various reports of rare adverse effects have emerged, leading to a significant clinical and prognostic impact. We aimed to provide a systematic review of mainly case-reports on rare events, to help physicians to make an accurate and fast diagnosis. Read More

Eur J Pharm Biopharm 2021 Aug 7;165:22-30. Epub 2021 May 7.

Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.

Drug delivery to the colon offers great promise for local treatment of colonic diseases as it allows bypassing systemic absorption in the small intestine, thereby increasing luminal drug concentrations in the colon. The primary objective of this in vivo pharmaco-scintigraphy study was to assess the colon drug targeting accuracy of a metronidazole benzoate colonic drug delivery system intended for local treatment of Clostridioides difficile infections. Additionally, it was assessed if the concept of mucoadhesion would increase colonic residence time and promote higher drug bioavailability. Read More

Case Rep Gastroenterol 2020 Sep-Dec;14(3):522-526. Epub 2020 Oct 27.

Pediatric Gastroenterology, Peyton Manning Children's Hospital, Indianapolis, Indiana, USA.

infection rates have been rising within the last decade and more pediatric patients have been suffering from this type of infection. However, this bacterium is a well-known contaminant in the normal flora of the colon in patients under the age of 2 years, and therefore consensus guidelines have recommended against routine testing for this infection, unless clinically indicated. We present here a case of a very young infant who presented with symptoms of food refusal, poor weight gain, abdominal distention, and colitis noted on imaging. Read More

Gastroenterology 2020 10 20;159(4):1431-1443.e6. Epub 2020 Jun 20.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia. Electronic address:

Background & Aims: The protease plasmin is an important wound healing factor, but it is not clear how it affects gastrointestinal infection-mediated damage, such as that resulting from Clostridioides difficile. We investigated the role of plasmin in C difficile-associated disease. This bacterium produces a spore form that is required for infection, so we also investigated the effects of plasmin on spores. Read More

Chirurgia (Bucur) 2020 Mar-Apr;115(2):227-235

The emergency surgery for colorectal cancer is associated with high rates of morbidity and mortality due to factors related to the characteristics of the patients but also the therapeutic attitude. This study aims to identify the surgical interventions associated with the postoperative complications, with the main causes of morbidity, with the reinterventions and with the postoperative deaths. We included in this retrospective study 431 patients hospitalized and operated in an emergency for complicated colorectal malignant tumors in the Surgery II Clinic of the Clinical Emergency County Hospital "Sf. Read More

Clin Transl Gastroenterol 2020 03;11(3):e00134

Department of Medicine B, Gastroenterology and Hepatology, University Hospital Münster, Münster, Germany.

Objectives: In patients with inflammatory bowel disease (IBD), a treat-to-target treatment strategy requires tight monitoring of disease activity. Noninvasive biomarkers may help to monitor the intestinal disease activity. We demonstrated recently that peripheral microRNA (miR)-320a expression in mice follows the course of experimental colitis. Read More

Surg J (N Y) 2020 Jan 3;6(1):e37-e41. Epub 2020 Mar 3.

Department of Internal Medicine and Medical Gastroenterology, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.

Hepatic portal venous gas (HPVG), a rare radiological finding, is historically considered an ominous sign with 100% mortality rates. The dictum that HPVG warrants surgical intervention is challenged in the recent literature. This is because of the identification of various causes of HVPG other than bowel gangrene. Read More

Diagn Microbiol Infect Dis 2020 Jan 24;96(1):114915. Epub 2019 Oct 24.

Specialty Internal Medicine and Quality Department, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Johns Hopkins University School of Medicine, Baltimore, MD, USA; General Internal Medicine Unit, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.

Clostridioides (Clostridium) difficile infection manifests as intestinal infections, namely pseudomembranous colitis. The occurrence of extra-intestinal disease is thought to be rare with a rate of 1.08% of 2034 isolates of C. Read More

Surg Endosc 2020 09 10;34(9):4101-4109. Epub 2019 Oct 10.

Division of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, Box 1259, New York, NY, 10029, USA.

Background: Transanal total mesorectal excision (taTME) is a surgical approach for low rectal cancer with a learning curve estimated at 40-50 cases. The experience among taTME surgeons beyond their learning curve is limited.

Methods: A retrospective analysis of all taTME cases performed for rectal cancer at two tertiary care hospitals from 2014 to 2019 was conducted. Read More

Hosp Pediatr 2019 09 7;9(9):736-738. Epub 2019 Aug 7.

Wolfson Children's Hospital, Jacksonville, Florida; and.

Radiol Med 2019 Dec 13;124(12):1185-1198. Epub 2019 Jul 13.

Department of Radiology, Azienda Ospedaliero-Universitaria Careggi, Largo G.A. Brambilla 3, 50134, Florence, Italy.

Clostridium difficile infection (CDI) is a severe and potentially deadly infectious colitis whose incidence is dramatically increasing in the last decades, with more virulent strains. CDI should be suspected in case of unexplained diarrhea and abdominal pain in patients with a recent history of antibiotic use and healthcare exposures; diagnosis is based on a combination of clinical and laboratory findings with demonstration of C. difficile toxins by stool test. Read More

J Minim Invasive Gynecol 2020 May - Jun;27(4):883-891. Epub 2019 Jun 22.

Benign Gynecology Surgery Section, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, Ohio (Dr. Kho).

Study Objective: To validate the algorithm for selective bowel surgery based on preoperative imaging by comparing the perioperative outcomes of patients who undergo each type of bowel surgery for deep bowel disease, and secondarily to evaluate the incidence, factors, and subsequent outcomes when the actual procedure performed deviated from the preoperative surgical plan.

Design: Retrospective study comparing 3 surgical interventions in an intention-to-treat analysis.

Setting: Tertiary care hospital. Read More

J Gastrointestin Liver Dis 2019 06 1;28:245-246. Epub 2019 Jun 1.

Medical Imaging Department, Emergency County Clinical Hospital Sibiu, Romania.

. Read More

Am J Gastroenterol 2019 11;114(11):1708

Division of Gastroenterology, City of Hope National Medical Center, Duarte, California, USA.

J Obstet Gynaecol Res 2019 Jul 7;45(7):1215-1221. Epub 2019 May 7.

Division of Gastroenterology, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Umberto I Hospital, Rome, Italy.

Ulcerative colitis (UC) is a chronic inflammatory disease rarely arising during gestation. Because the available information is based on case reports or small retrospective studies, diagnosis may be difficult and treatment is still controversial. A case of toxic megacolon developing in late pregnancy associated to a sudden fetal decompensation is described. Read More

Gastroenterology 2019 12 4;157(6):1492-1493. Epub 2019 May 4.

Division of Gastroenterology and Hepatology, Department of Medicine, Cook County Health and Hospital System, County, Chicago, Illinois.

Clin J Gastroenterol 2019 Aug 14;12(4):325-329. Epub 2019 Feb 14.

Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.

We report a case of community-acquired fulminant colitis caused by Clostridium difficile in Japan. A 46-year-old woman was diagnosed with severe infectious enterocolitis and was admitted at another hospital. The stool culture was positive for toxigenic C. Read More

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Pediatric Surgery, Children's Health Children's Medical Center Dallas, Dallas, Texas, USA.

A 16-year-old Hispanic man was transferred to our level I paediatric trauma centre with pancreatitis. Ten days prior, he had sustained a gunshot wound to the abdomen requiring an exploratory laparotomy for repair of a traumatic left diaphragmatic injury. Additional injuries included gastric, renal, liver and pancreatic lacerations as well as a T12 burst fracture that resulted in paraplegia. Read More

Masui 2017 May;66(5):503-507

Point-of-care ultrasound (POCUS) in the diagnoses of postoperative complications is discussed. POCUS is useful in many situations such as abdominal distension, elevated liver enzymes, abdominal pain, and fever, which are the common complications encountered after surgical operations. In the patients with abdominal distention, bowel distention or ascites can be easily detected by POCUS. Read More

Radiologe 2018 Apr;58(4):302-311

Klinik für diagnostische und interventionelle Radiologie und Neuroradiologie, Clemenshospital Münster, Düesbergweg 124, 48153, Münster, Deutschland.

Background: Computed tomography (CT) is often used as the initial diagnostic test in patients with inflammatory and infectious types of enterocolitis. The differential diagnosis is broad, including infectious, non-infectious and vascular causes, which have substantially different management strategies. Although a definitive diagnosis often relies on endoscopic biopsy results, stool culture results or other clinical features, radiologists often help to guide the diagnosis. Read More

Rev Gastroenterol Mex (Engl Ed) 2019 Jan - Mar;84(1):110-112. Epub 2018 Feb 12.

Instituto de Investigación en Inmunodeficiencias y VIH, Departamento de Clínicas Médicas, CUCS - Universidad de Guadalajara, Guadalajara, Jalisco, México.

Gastroenterology 2018 08 2;155(2):e11-e12. Epub 2018 Feb 2.

Department of Gastroenterology and Hepatology, University of Alabama at Birmingham, Alabama.

BMJ Case Rep 2018 Jan 26;2018. Epub 2018 Jan 26.

Imaging Department, Barts Health NHS Trust, London, UK.

While imaging appearances of pseudomembranous colitis are commonly recognised, radiological manifestations of -associated enteritis are poorly understood which, combined with the rarity of this infection involving small bowel, makes establishing the correct diagnosis challenging. Therefore, in order to encourage awareness of readers, we present a case of enteritis that manifested as abdominal sepsis complicating the postoperative period in a middle-aged woman with fistulating Crohn's disease and defunctioning ileostomy. Radiological appearances are described based on three consecutive CT studies performed 5 days prior to onset of symptoms, during the peak of enteritis, corresponding with the patient's clinical deterioration, and also 35 days later following treatment and resolution. Read More

Medicine (Baltimore) 2017 Aug;96(33):e7793

Division of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University Graz, Graz Division of General Pediatrics and Adolescent Medicine, Hospital Wels-Grieskirchen, Wels Microbiologic Laboratory, Institute of Pathology, General Hospital Hochsteiermark, Leoben Institute of Pathology, Medical University Graz, Graz Division of Pediatrics and Adolescent Medicine Institute of Microbiology, Medical University Innsbruck, Innsbruck Division of Pediatrics and Adolescent Medicine, General Hospital Hochsteiermark, Leoben Institute of Pathology, Hospital Oberwart, Oberwart Department of Internal Medicine, Medical University Graz Institute of Hygiene, Microbiology and Environmental Medicine Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University Graz Institute of Molecular Biosciences, Karl-Franzens University Graz, Graz Division of Pediatrics and Adolescent Medicine, Hospital Oberwart, Oberwart Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Graz, Austria.

Diseases causing hematochezia range from benign to potentially life-threatening. Systematic pediatric data on the causes of hematochezia are scarce. We studied the underlying causes and long-term outcome of hematochezia in children. Read More

Rev Esp Enferm Dig 2017 Sep;109(9):670

Aparato Digestivo, Hospital Universitario de Cabueñes.

Clostridium difficile (CD) infection is currently the most frequent etiology of nosocomial diarrhea. Besides, its incidence is progressively increasing in ambulatory patients. Inflammatory bowel disease (IBD) is a risk factor of CD infection itself, but also due to the regular immunosuppressive treatment used in these patients. Read More

BMJ Case Rep 2017 Jun 18;2017. Epub 2017 Jun 18.

Department of Anaesthetics, Cheltenham General Hospital, Cheltenham, UK.

A 75-year-old man was admitted with abdominal pain and fresh rectal bleeding. Significantly, he had no risk factors for infection. An abdominal CT demonstrated colonic thickening, and flexible sigmoidoscopy identified pseudomembranous colitis-like lesions. Read More

Curr Drug Saf 2017 ;12(3):205-207

CM 31/13, Shantinagar 2, Near Bhagwati Circle, Kalvibid, Bhavnagar-364002, Gujarat. India.

Introduction: Incidence of antibiotic- associated diarrhoea is a common (10-30%) but pseudomembranous colitis (PMC) is less frequent (1-5%). Fluoroquinolones, clindamycin, penicillins, cephalosporins (mostly third generation) are commonly associated with PMC. The association between cephalosporins and PMC is now well established. Read More

World J Gastroenterol 2017 Apr;23(16):3003-3010

Wolfgang Kreisel, Bertram Bengsch, Anna-Maria Globig, Department of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Protein-losing enteropathy (PLE) is characterized by loss of serum proteins into the gastrointestinal tract. It may lead to hypoproteinemia and clinically present as protein deficiency edema, ascites, pleural or pericardial effusion and/or malnutrition. In most cases the site of protein loss is the small intestine. Read More

Rev Gastroenterol Mex 2017 Oct - Dec;82(4):301-308. Epub 2017 Mar 29.

Servicio de Infectología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México; Instituto de Patología Infecciosa y Experimental, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.

Introduction And Aims: Clostridium difficile infection is the main cause of hospital-acquired diarrhea, and the clinical and endoscopic findings in those patients have been studied very little in Mexico. The aim of the present study was to describe those findings.

Materials And Methods: A prospective cohort study was conducted that included patients with hospital-acquired diarrhea associated with Clostridium difficile diagnosed through polymerase chain reaction. Read More