8,187 results match your criteria Pseudomembranous Colitis


Antimicrobial susceptibilities of isolated in 12 Asia-Pacific countries, 2014-15.

Antimicrob Agents Chemother 2020 May 11. Epub 2020 May 11.

School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.

causes toxin-mediated diarrhoea and pseudomembranous colitis, primarily among hospital inpatients. Outbreaks of infection (CDI) have been caused by strains with acquired antimicrobial resistance, particularly fluoroquinolone resistance, including ribotype (RT) 027 in North America and Europe, and RT 017, the most common strain in Asia. Despite being the most common cause of hospital-acquired infection in high-income countries, and frequent misuse of antimicrobials in Asia, little is known about CDI in the Asia-Pacific region. Read More

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http://dx.doi.org/10.1128/AAC.00296-20DOI Listing

The Bioinformatic and In Vitro Studies of Clostridioides Difficile Aminopeptidase M24 Revealed the Immunoreactive KKGIK Peptide.

Cells 2020 May 7;9(5). Epub 2020 May 7.

Department of Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.

(CD) is a Gram-positive pathogen responsible for CD-associated disease (CDAD), which is characterized by symptoms ranging from mild diarrhea to pseudomembranous colitis. This work is an attempt to respond to the need of novel methods for CD infection (CDI) prevention, since the number of CDI cases is still rising. A bioinformatics approach was applied to design twenty-one peptides consisting of in silico predicted linear B-cell and T-cell epitopes of aminopeptidase M24 from CD. Read More

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http://dx.doi.org/10.3390/cells9051146DOI Listing

The Influence of the Type of Surgery on the Immediate Postoperative Results in Patients with Colorectal Cancer Operated in Emergency.

Chirurgia (Bucur) 2020 Mar-Apr;115(2):227-235

The emergency surgery for colorectal cancer is associated with high rates of morbidity and mortality due to factors related to the characteristics of the patients but also the therapeutic attitude. This study aims to identify the surgical interventions associated with the postoperative complications, with the main causes of morbidity, with the reinterventions and with the postoperative deaths. We included in this retrospective study 431 patients hospitalized and operated in an emergency for complicated colorectal malignant tumors in the Surgery II Clinic of the Clinical Emergency County Hospital "Sf. Read More

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http://dx.doi.org/10.21614/chirurgia.115.2.227DOI Listing

Evaluation of glutamate dehydrogenase (GDH) and toxin A/B rapid tests for Clostridioides (prev. Clostridium) difficile diagnosis in a university hospital in Minas Gerais, Brazil.

Braz J Microbiol 2020 May 4. Epub 2020 May 4.

Veterinary School, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31.270-901, Brazil.

Clostridioides (Clostridium) difficile is responsible for most cases of nosocomial diarrhea and, despite the high prevalence of the disease worldwide, the best laboratory diagnostic approach to diagnose C. difficile infection (CDI) is a subject of ongoing debate. Although the use of multiple tests is recommended, the cost of these algorithms commonly exceeds the affordability in some countries. Read More

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http://dx.doi.org/10.1007/s42770-020-00288-zDOI Listing

Guidelines for infection in adults.

Prz Gastroenterol 2020 19;15(1):1-21. Epub 2020 Mar 19.

Central Clinical Hospital of Ministry of Inferior and Administration, Warsaw, Poland.

infection (CDI) has become a serious medical and epidemiological problem, especially in well developed countries. There has been evident increase in incidence and severity of CDI. Prevention, proper diagnosis and effective treatment are necessary to reduce the risk for the patients, deplete the spreading of infection and diminish the probability of recurrent infection. Read More

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http://dx.doi.org/10.5114/pg.2020.93629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089862PMC

Development and Characterization of Mouse Monoclonal Antibodies Specific for Lipoteichoic Acid.

ACS Chem Biol 2020 04 1;15(4):1050-1058. Epub 2020 Apr 1.

Vaccine and Emerging Infections Research, Human Health Therapeutics Research Centre, National Research Council, Ottawa, Ontario K1A 0R6, Canada.

is an anaerobic Gram-positive, spore-forming nosocomial, gastrointestinal pathogen causing -associated disease with symptoms ranging from mild cases of antibiotic-associated diarrhea to fatal pseudomembranous colitis. We developed murine monoclonal antibodies (mAbs) specific for a conserved cell surface antigen, lipoteichoic acid (LTA)of . The mAbs were characterized in terms of their thermal stability, solubility, and their binding to LTA by surface plasmon resonance and competitive ELISA. Read More

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http://dx.doi.org/10.1021/acschembio.0c00066DOI Listing

Human peptide α-defensin-1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT.

FASEB J 2020 May 19;34(5):6244-6261. Epub 2020 Mar 19.

Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.

The human pathogenic bacterium Clostridioides difficile produces two exotoxins TcdA and TcdB, which inactivate Rho GTPases thereby causing C. difficile-associated diseases (CDAD) including life-threatening pseudomembranous colitis. Hypervirulent strains produce additionally the binary actin ADP-ribosylating toxin CDT. Read More

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http://dx.doi.org/10.1096/fj.201902816RDOI Listing

New Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection.

mBio 2020 Mar 10;11(2). Epub 2020 Mar 10.

Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA

Frequent and excessive use of antibiotics primes patients to infection (CDI), which leads to fatal pseudomembranous colitis, with limited treatment options. In earlier reports, we used a drug repurposing strategy and identified amoxapine (an antidepressant), doxapram (a breathing stimulant), and trifluoperazine (an antipsychotic), which provided significant protection to mice against lethal infections with several pathogens, including However, the mechanisms of action of these drugs were not known. Here, we provide evidence that all three drugs offered protection against experimental CDI by reducing bacterial burden and toxin levels, although the drugs were neither bacteriostatic nor bactericidal in nature and had minimal impact on the composition of the microbiota. Read More

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http://dx.doi.org/10.1128/mBio.00053-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064747PMC

Hepatic Portal Venous Gas: An Ill Omen or a Misleading Sign.

Surg J (N Y) 2020 Jan 3;6(1):e37-e41. Epub 2020 Mar 3.

Department of Internal Medicine and Medical Gastroenterology, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.

Hepatic portal venous gas (HPVG), a rare radiological finding, is historically considered an ominous sign with 100% mortality rates. The dictum that HPVG warrants surgical intervention is challenged in the recent literature. This is because of the identification of various causes of HVPG other than bowel gangrene. Read More

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http://dx.doi.org/10.1055/s-0040-1702919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054055PMC
January 2020

Physical, Laboratory, Radiographic, and Endoscopic Workup for Colitis.

Clin Colon Rectal Surg 2020 Mar 25;33(2):82-86. Epub 2020 Feb 25.

Department of Gastrointestinal Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

(reclassified as " ") colitis is a common nosocomial infection associated with increased morbidity and mortality. Like many clinical encounters, a focused history and physical examination will help to guide initial management. Further laboratory testing will assist with diagnosis through stool studies, and blood tests, such as white blood cell counts and serum creatinine, can help to stratify patients into illness severity groups for treatment decisions. Read More

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http://dx.doi.org/10.1055/s-0039-3400474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042018PMC

Microbe-microbe interactions during Clostridioides difficile infection.

Curr Opin Microbiol 2020 Feb 20;53:19-25. Epub 2020 Feb 20.

Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

Clostridioides difficile is the leading cause of hospital-acquired gastrointestinal infections and a major public health burden in the United States. C. difficile infection causes a spectrum of disease from mild diarrhea to severe complications such as pseudomembranous colitis, toxic megacolon and death. Read More

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http://dx.doi.org/10.1016/j.mib.2020.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244385PMC
February 2020

Clostridioides difficile Infection: Update on Management.

Am Fam Physician 2020 02;101(3):168-175

Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Guidelines for the diagnosis and treatment of Clostridioides difficile infection have recently been updated. Risk factors include recent exposure to health care facilities or antibiotics, especially clindamycin. C. Read More

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February 2020

The antibiotic vancomycin induces complexation and aggregation of gastrointestinal and submaxillary mucins.

Sci Rep 2020 Jan 22;10(1):960. Epub 2020 Jan 22.

National Centre for Macromolecular Hydrodynamics, School of Biosciences, University of Nottingham, Sutton Bonington, LE12 5RD, UK.

Vancomycin, a branched tricyclic glycosylated peptide antibiotic, is a last-line defence against serious infections caused by staphylococci, enterococci and other Gram-positive bacteria. Orally-administered vancomycin is the drug of choice to treat pseudomembranous enterocolitis in the gastrointestinal tract. However, the risk of vancomycin-resistant enterococcal infection or colonization is significantly associated with oral vancomycin. Read More

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http://dx.doi.org/10.1038/s41598-020-57776-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976686PMC
January 2020
5.078 Impact Factor

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.

J Exp Med 2020 Mar;217(3)

Laboratory of Immunoinflammation, Department of Genetics and Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.

Antibiotic-induced dysbiosis is a key predisposing factor for Clostridium difficile infections (CDIs), which cause intestinal disease ranging from mild diarrhea to pseudomembranous colitis. Here, we examined the impact of a microbiota-derived metabolite, short-chain fatty acid acetate, on an acute mouse model of CDI. We found that administration of acetate is remarkably beneficial in ameliorating disease. Read More

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http://dx.doi.org/10.1084/jem.20190489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062529PMC

infection in the Asia-Pacific region.

Emerg Microbes Infect 2020 24;9(1):42-52. Epub 2019 Dec 24.

Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan.

causes healthcare-related diarrhoea in high-income countries. Highly resistant spores persist in healthcare facilities, primarily infecting patients who have recently received antimicrobials. infection (CDI) has been studied in detail in North America and Europe; however, the epidemiology of CDI elsewhere, including the Asia-Pacific region, is largely unknown. Read More

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http://dx.doi.org/10.1080/22221751.2019.1702480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968625PMC

Commentary: faecal microbiota transplantation-from home brew to holy grail.

Aliment Pharmacol Ther 2020 01;51(1):208-209

Lynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA.

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http://dx.doi.org/10.1111/apt.15553DOI Listing
January 2020

The current novel therapeutic regimens for infection (CDI) and the potentials of Traditional Chinese Medicine in treatment of CDI.

Crit Rev Microbiol 2019 Sep - Nov;45(5-6):729-742. Epub 2019 Dec 14.

China Academy of Chinese Medical Sciences, Beijing, China.

infection (CDI) is featured as the dysbiosis of gut microbiota and consequent mild diarrhoea or severe pseudomembranous colitis. However, the frequent recurrence of CDI following treatment course challenged the antibiotic therapy. Currently, to address the relapse of CDI, several novel therapeutic approaches have emerged, including Bezlotoxumab, SYN-004 (Ribaxamase), RBX2660, and faecal microbial transplant. Read More

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http://dx.doi.org/10.1080/1040841X.2019.1700905DOI Listing

Growing consumption of antibiotics and epidemiology of infections in Poland: A need to develop new solutions.

Acta Microbiol Immunol Hung 2019 Dec 9:1-8. Epub 2019 Dec 9.

Department of Microbiology, Faculty of Medicine, Jagiellonian University Collegium Medicum, Kraków, Poland.

(formerly ) infections (CDIs) are becoming more common and more serious. is the etiologic agent of antibiotic-associated diarrhea, pseudomembranous enterocolitis, and toxic megacolon while CDIs recur in 7.9% of patients. Read More

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http://dx.doi.org/10.1556/030.66.2019.024DOI Listing
December 2019

Acute oxalate nephropathy associated with infection.

BMJ Case Rep 2019 Dec 5;12(12). Epub 2019 Dec 5.

Department of Nephrology, Saint Vincent Hospital, Worcester, Massachusetts, USA.

Acute oxalate nephropathy has been associated with chronic diarrheal illness and only one case has been reported due to acute diarrhea secondary to colitis. To the best of our knowledge, this is the second case report of acute oxalate nephropathy due to colitis. A 75-year-old man with a medical history of hypertension, type 2 diabetes mellitus, chronic kidney disease stage IV, recent colitis was admitted for acute kidney injury with a creatinine (Cr) of 8. Read More

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http://dx.doi.org/10.1136/bcr-2019-231099DOI Listing
December 2019

infection: Is there a change in the underlying factors? Inflammatory bowel disease and .

Saudi J Gastroenterol 2019 Nov-Dec;25(6):384-389

Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakif University, Istanbul, Turkey.

Background / Aims: Clostridium difficile is a Gram-positive, strict anaerobe, spore-forming bacterium. It can cause self-limiting mild diarrhea, severe diarrhea, pseudomembranous colitis, and fatal fulminant colitis. We aimed to investigate the changes in epidemiology and incidence of C. Read More

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http://dx.doi.org/10.4103/sjg.SJG_44_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941457PMC
December 2019

Atypical presentation of pseudomembranous colitis with laboratory rejection of stool specimen.

BMJ Case Rep 2019 Nov 26;12(11). Epub 2019 Nov 26.

Department of Gastroenterology, University of Virginia, Charlottesville, Virginia, USA.

(formerly ) is a major cause of nocosomial infection in the USA and worldwide. It has a wide spectrum of presentation, ranging from an asymptomatic carrier state to fulminant colitis. Pseudomembranous colitis is a manifestation of severe infection (CDI), typically with progressive symptoms including watery diarrhoea, abdominal cramping and fevers and elevated white cell count and/or creatinine. Read More

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http://dx.doi.org/10.1136/bcr-2019-230629DOI Listing
November 2019

Evolving Strategies to Manage Clostridium difficile Colitis.

J Gastrointest Surg 2020 Feb 25;24(2):484-491. Epub 2019 Nov 25.

Department of Surgery, University of California, Davis, Medical Center, 2335 Stockton Blvd., Sacramento, CA, 95817, USA.

Clostridium difficile infection remains a common nosocomial illness with a significant impact on health care delivery. As molecular phenotyping of this organism has changed our understanding of its transmission and virulence, so too have diagnostic methods and treatment strategies evolved in recent years. The burden of this infection falls predominantly on elderly patients with comorbidities who have recently received antibiotics. Read More

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http://dx.doi.org/10.1007/s11605-019-04478-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031036PMC
February 2020

Mapping Epitopes of a Novel Peptidoglycan Cross-Linking Enzyme Cwp22 Recognized by Human Sera Obtained from Patients with Infection and Cord Blood.

Microorganisms 2019 Nov 14;7(11). Epub 2019 Nov 14.

Department of Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.

(CD) cause a severe diarrhea which can lead to pseudomembranous colitis and even patient death. CD infection (CDI) is connected mainly with changes in intestinal microbiota as a consequence of antibiotic treatment. The growing resistance to antibiotics, justifies the search for new methods of combating CD. Read More

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http://dx.doi.org/10.3390/microorganisms7110565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920951PMC
November 2019

Multi-focal Clostridioides (Clostridium) difficile osteomyelitis in a patient with sickle cell anemia: case presentation and literature review.

Diagn Microbiol Infect Dis 2020 Jan 24;96(1):114915. Epub 2019 Oct 24.

Specialty Internal Medicine and Quality Department, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Johns Hopkins University School of Medicine, Baltimore, MD, USA; General Internal Medicine Unit, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.

Clostridioides (Clostridium) difficile infection manifests as intestinal infections, namely pseudomembranous colitis. The occurrence of extra-intestinal disease is thought to be rare with a rate of 1.08% of 2034 isolates of C. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2019.114915DOI Listing
January 2020

Interpreting Reported Risks Associated With Use of Proton Pump Inhibitors: Residual Confounding in a 10-Year Analysis of National Ambulatory Data.

Gastroenterology 2020 02 31;158(3):780-782.e3. Epub 2019 Oct 31.

Department of Medicine, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.10.023DOI Listing
February 2020

Fecal microbiota transplant for C. difficile infection: Just say yes.

Anaerobe 2019 Dec 20;60:102109. Epub 2019 Oct 20.

Dipartimento di Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168, Roma, Italy. Electronic address:

The burden of Clostridium difficile associated diarrhea is a worrying clinical issue worldwide, mainly as regarding the high incidence of recurrences after standard antibiotic therapy and the risk for more severe clinical manifestations. For this reason, new and more effective therapies are needed for the treatment of recurrent episodes. Fecal microbiota transplantation seems to be a valid tool considering the mechanism of action and the growing number of studies that demonstrate its clinical efficacy. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.102109DOI Listing
December 2019

Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE).

Gut 2020 01 14;69(1):83-91. Epub 2019 Oct 14.

Center for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong, China.

Objective: The underlying microbial basis, predictors of therapeutic outcome and active constituent(s) of faecal microbiota transplantation (FMT) mediating benefit remain unknown. An international panel of experts presented key elements that will shape forthcoming FMT research and practice.

Design: Systematic search was performed, FMT literature was critically appraised and a 1-day round-table discussion was conducted to derive expert consensus on key issues in FMT research. Read More

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http://dx.doi.org/10.1136/gutjnl-2019-319407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943253PMC
January 2020
6 Reads

Transanal total mesorectal excision (taTME) for rectal cancer: beyond the learning curve.

Surg Endosc 2019 Oct 10. Epub 2019 Oct 10.

Division of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, Box 1259, New York, NY, 10029, USA.

Background: Transanal total mesorectal excision (taTME) is a surgical approach for low rectal cancer with a learning curve estimated at 40-50 cases. The experience among taTME surgeons beyond their learning curve is limited.

Methods: A retrospective analysis of all taTME cases performed for rectal cancer at two tertiary care hospitals from 2014 to 2019 was conducted. Read More

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http://dx.doi.org/10.1007/s00464-019-07172-4DOI Listing
October 2019
1 Read

Medical students' perception on fecal microbiota transplantation.

BMC Med Educ 2019 Oct 11;19(1):368. Epub 2019 Oct 11.

2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background: Fecal microbiota transplantation (FMT) has become an emergent method in the therapy of several intestinal diseases, mainly in Clostridium difficile recurrence. The training of FMT in medical schools is at its beginning and in countries where FMT is only occasionally carried out, it is important to know the perception of medical students on FMT.

Methods: We undertook a survey of 3rd year medical students not exposed to official academic information on FMT in order to find out their knowledge, beliefs and attitude toward FMT. Read More

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http://dx.doi.org/10.1186/s12909-019-1804-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788000PMC
October 2019
1 Read

New concepts in C. difficile management.

Authors:
Y R Mahida

Br Med Bull 2019 09;131(1):109-118

Nottingham Digestive Diseases Centre, Queen's Medical Centre, Nottingham, UK.

Background: Clostridium difficile infection is transmitted via spores, and the disease is mediated via secreted toxins. It represents a significant healthcare problem, and clinical presentation can range from asymptomatic carriage to life-threatening pseudomembranous colitis.

Sources Of Data: publications in the field, with a focus on recent developments and concepts. Read More

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http://dx.doi.org/10.1093/bmb/ldz029DOI Listing
September 2019
3 Reads

Highlights from Gastro Update Europe - Budapest June 26-27, 2019.

Authors:
Guido N J Tytgat

Arab J Gastroenterol 2019 Sep 27;20(3):148-162. Epub 2019 Sep 27.

Department Gastroenterology-Hepatology, Meibergdreef, 1105 AZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/j.ajg.2019.09.002DOI Listing
September 2019

Acute Onset Rectal Prolapse with a Pseudomembranous Covering.

J Pediatr 2019 12 27;215:281-281.e1. Epub 2019 Sep 27.

Department of Pediatric Surgery, Takatsuki Hospital, Takatsuki, Japan.

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http://dx.doi.org/10.1016/j.jpeds.2019.08.044DOI Listing
December 2019
2 Reads

Minimally invasive Venetian blinds ventral hernia repair with botulinum toxin chemical component separation.

ANZ J Surg 2020 01 30;90(1-2):67-71. Epub 2019 Sep 30.

Department of Surgery, St George Hospital, Sydney, New South Wales, Australia.

Background: Laparoscopic ventral repair is safe, with lower wound infection rates compared with open repair. 'Venetian blinds' technique of plication in combination with mesh reinforcement, is totally intra-corporeal, with hernia defect and sac plication to reduce seroma formation. While laparoscopic suturing of the abdominal wall can represent a technical challenge, pre-operative botulinum toxin A (BTA) injections as an adjunct can assist. Read More

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http://dx.doi.org/10.1111/ans.15438DOI Listing
January 2020
5 Reads

Fecal microbiota transplantation as an effective initial therapy for pancreatitis complicated with severe infection: A case report.

World J Clin Cases 2019 Sep;7(17):2597-2604

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.

Background: Moderately severe acute pancreatitis (MSAP) is a critical form of acute pancreatitis that is related with high morbidity and mortality. Severe infection (sCDI) is a serious and rare nosocomial diarrheal complication, especially in MSAP patients. Fecal microbiota transplantation (FMT) is a highly effective treatment for refractory and recurrent CDI (rCDI). Read More

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http://dx.doi.org/10.12998/wjcc.v7.i17.2597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745327PMC
September 2019
3 Reads

Reply to Tenover et al., "Guidelines Support the Value of Stand-Alone Nucleic Acid Amplification Tests for () Infection".

J Clin Microbiol 2019 10 24;57(10). Epub 2019 Sep 24.

Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.

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http://dx.doi.org/10.1128/JCM.01157-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760938PMC
October 2019

Guidelines Support the Value of Stand-Alone Nucleic Acid Amplification Tests for () Infection.

J Clin Microbiol 2019 10 24;57(10). Epub 2019 Sep 24.

University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1128/JCM.01079-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760941PMC
October 2019

Clostridium difficile infection: Description of NAP1/027 and non NAP1/027 strains in a high complexity center in Cali, Colombia, 2012-2015

Biomedica 2019 05 1;39(s1):63-70. Epub 2019 May 1.

Servicio de Medicina Interna, Centro Médico Imbanaco, Cali, Colombia; Resistencia bacteriana, CIDEIM, Cali, Colombia; Departamento de Medicina Interna, Escuela de Medicina, Universidad del Valle, Cali, Colombia.

Introduction: Clostridium difficile causes nosocomial infections leading to high morbidity and mortality. The NAP1/027 strain is associated with a higher toxin production and disease severity, which increases the load of the disease. Objective: To describe the epidemiology of the infections associated with C. Read More

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http://dx.doi.org/10.7705/biomedica.v39i2.3950DOI Listing

Vaccine Production to Protect Animals Against Pathogenic Clostridia.

Toxins (Basel) 2019 09 11;11(9). Epub 2019 Sep 11.

Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.

is a broad genus of anaerobic, spore-forming, rod-shaped, Gram-positive bacteria that can be found in different environments all around the world. The genus includes human and animal pathogens that produce potent exotoxins that cause rapid and potentially fatal diseases responsible for countless human casualties and billion-dollar annual loss to the agricultural sector. Diseases include botulism, tetanus, enterotoxemia, gas gangrene, necrotic enteritis, pseudomembranous colitis, blackleg, and black disease, which are caused by pathogenic . Read More

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http://dx.doi.org/10.3390/toxins11090525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783934PMC
September 2019
2 Reads

Identifying Efficient Toxin A Binders with a Multivalent Neo-Glycoprotein Glycan Library.

Bioconjug Chem 2019 09 9;30(9):2373-2383. Epub 2019 Sep 9.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering , RWTH Aachen University , Pauwelsstrasse 20 , 52074 Aachen , Germany.

infections cause gastrointestinal disorders and can lead to life-threatening conditions. The symptoms can vary from severe diarrhea to the formation of pseudomembranous colitis and therefore trigger a need for new therapies. The initial step of disease is the binding of the bacterial enterotoxins toxin A and B to the cell surface of epithelial intestinal cells. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00486DOI Listing
September 2019
1 Read

Doctor, my patient has CDI and should continue to receive antibiotics. The (unresolved) risk of recurrent CDI.

Rev Esp Quimioter 2019 Sep;32 Suppl 2:47-54

Miguel Salavert Lletí. Unidad de Enfermedades Infecciosas. Hospital Universitario y Politécnico La Fe; Valencia. Av. Fernando Abril Martorell, nº 106; 46026-Valencia. Spain.

Recurrence rate ranges from 12% to 40% of all cases of Clostridium difficile infection (CDI) and proposes an exceptional clinical challenge. Conventionally, treatment options of CDI have been limited to regimes of established antibiotics (eg, pulsed/tapered vancomycin) or "improvised" alternative antibiotics (eg. teicoplanin, tigecycline, nitazoxanide or rifaximin) occasionally even in combination, but faecal microbiota transplantation is emerging as a useful and quite safe alternative. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755365PMC
September 2019

The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Toxin TcdB.

Stem Cells Int 2019 5;2019:4149762. Epub 2019 Aug 5.

Institute of Pharmacology and Toxicology, University of Ulm Medical Center, 89081 Ulm, Germany.

Bacitracin is an established antibiotic for local application and inhibits the cell wall synthesis of Gram-positive bacteria. Recently, we discovered a completely different mode of action of bacitracin and reported that this drug protects human cells from intoxication by a variety of medically relevant bacterial protein toxins including CDT, the binary actin ADP-ribosylating toxin of () . Bacitracin prevents the transport of CDT into the cytosol of target cells, most likely by inhibiting the transport function of the binding subunit of this toxin. Read More

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http://dx.doi.org/10.1155/2019/4149762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701344PMC
August 2019
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Closing in on C. difficile infection.

Authors:
Katrina Ray

Nat Rev Gastroenterol Hepatol 2019 10;16(10):581

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0206-yDOI Listing
October 2019

An Unusual Case of Clostridium Difficile Colitis and Hemolytic Uremic Syndrome in a Teenager.

S D Med 2019 Jul;72(7):294-297

Avera Medical Group - Hematology and Bone Marrow Transplant, Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota.

The term hemolytic uremic syndrome (HUS) refers to a heterogenous group of disorders arising from an initial endothelial cell injury with fibrin and platelet thrombi formation in the vasculature, leading to severe organ damage resulting in the well-known triad of microangiopathic hemolytic anemia, thrombocytopenia and kidney disease. The majority of pediatric cases (90 percent) of HUS are caused by Shiga toxin-producing Escherichia coli (STEC-HUS) or Shigella dysenteriae and rarely with Streptococcus pneumoniae (Pneumococcal-HUS). Atypical hemolytic uremic syndrome (aHUS) constitute only 5 percent of all HUS cases and are mediated by dysregulation of complement proteins. Read More

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July 2019
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: diagnosis and treatments.

BMJ 2019 Aug 20;366:l4609. Epub 2019 Aug 20.

National Reference Laboratory for Clostridium difficile, Paris, France.

(formerly ) is a major cause of healthcare associated diarrhea, and is increasingly present in the community. Historically, infection was considered easy to diagnose and treat. Over the past two decades, however, diagnostic techniques have changed in line with a greater understanding of the physiopathology of infection and the use of new therapeutic molecules. Read More

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http://dx.doi.org/10.1136/bmj.l4609DOI Listing
August 2019
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Clostridium difficile infection associated with metronidazole-based treatment for Helicobacter pylori eradication.

Gastroenterol Hepatol 2019 Oct 6;42(8):524. Epub 2019 Aug 6.

Medicina Familiar y Comunitaria, Centro de Salud Covaresa, Valladolid Oeste, Valladolid, España.

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http://dx.doi.org/10.1016/j.gastrohep.2019.05.001DOI Listing
October 2019
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It's Okay to Blink and Miss It.

Hosp Pediatr 2019 09 7;9(9):736-738. Epub 2019 Aug 7.

Wolfson Children's Hospital, Jacksonville, Florida; and.

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http://dx.doi.org/10.1542/hpeds.2019-0022DOI Listing
September 2019

Microbiological evaluation of the ability of the DEKO-190 Washer/Disinfector to remove Clostridium difficile spores from bedpan surfaces.

Infect Dis Health 2019 11 3;24(4):208-211. Epub 2019 Aug 3.

School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Australia; School of Medical & Health Sciences, Edith Cowan University, Joondalup, Australia; Department of Microbiology, PathWest Laboratory Medicine, Nedlands, Australia; School of Veterinary & Life Sciences, Murdoch University, Murdoch, Australia.

Background: Clostridium difficile is a major nosocomial pathogen causing mild diarrhoea to life-threatening pseudomembranous colitis, and its spores frequently contaminate hospital environments and equipment. Washer/Disinfectors (WDs) are commonly used to clean and decontaminate soiled equipment in health care facilities. This study aimed to evaluate the effectiveness of the DEKO-190 WD in removing C. Read More

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http://dx.doi.org/10.1016/j.idh.2019.07.001DOI Listing
November 2019
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Enterocolitis in a Captive Geoffroy's Spider Monkey () and Common Marmosets ().

Vet Pathol 2019 11 5;56(6):959-963. Epub 2019 Aug 5.

University of Pittsburgh, Pittsburgh, PA, USA.

is a well-documented cause of enterocolitis in several species, including humans, with limited documentation in New World nonhuman primates. We report several cases of -associated pseudomembranous enterocolitis, including a case in a Geoffroy's spider monkey () and several cases in common marmosets (). The histologic lesions included a spectrum of severity, with most cases characterized by the classic "volcano" lesions described in humans and several other animal species. Read More

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http://dx.doi.org/10.1177/0300985819864307DOI Listing
November 2019
3 Reads