493 results match your criteria Pseudolymphoma Cutaneous

Squamous Cell Carcinoma and Tattoo: A Man With a Tattoo-Associated Squamous Cell Carcinoma and Review of Benign Tumors, Lymphoid Conditions, and Malignant Neoplasms Occurring Within a Tattoo.

Philip R Cohen

Cureus 2022 Jan 10;14(1):e21083. Epub 2022 Jan 10.

Dermatology, University of California, Davis Medical Center, Sacramento, USA.

Tattoos, a common form of body adornment, have been associated with numerous cutaneous complications. These include not only benign neoplasms and malignant tumors but also lymphoid conditions occurring within the tattoo. Tattoo-associated dermatomyofibroma, epidermoid inclusion cyst, hemangioma, lipoma, milia, and pilomatricoma are benign lesions that have each only been described in one individual. Read More

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January 2022

Dramatic resolution of cutaneous lymphoid hyperplasia after receiving intravenous immunoglobulin for COVID-19.

Dermatol Ther 2022 Apr 12;35(4):e15347. Epub 2022 Feb 12.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

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Cutaneous Lymphoid Hyperplasia With T-Cell Clonality and Monotypic Plasma Cells Secondary to a Tick Bite: A Hidden Critter and the Power of Deeper Levels.

Am J Dermatopathol 2022 Mar;44(3):226-229

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX; and.

Abstract: Cutaneous lymphoid hyperplasia (CLH) is a benign reactive process with T-cell or B-cell lymphocytic infiltration in the skin, which can simulate cutaneous lymphomas both clinically and histologically. Various antigenic stimuli have been implicated in the development of CLH, including tick bites. Finding histologic evidence of such triggering factors, however, is often difficult. Read More

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Baby Wet Wipes: An Unusual Culprit of Lymphomatoid Contact Dermatitis Mimicking Mycosis Fungoides.

Am J Dermatopathol 2022 Mar;44(3):205-206

Department of Dermatology, Boston University School of Medicine, Boston, MA.

Abstract: Lymphomatoid contact dermatitis (LCD) is a rare, benign pseudolymphoma with clinicopathologic features of both allergic contact dermatitis and cutaneous T-cell lymphoma (CTCL). In this article, we report a fascinating case of LCD secondary to chronic baby wet wipe use with clinical features of allergic contact dermatitis and histopathologic changes of mycosis fungoides, a subtype of CTCL. We argue that LCD should be added to the list of mimickers of mycosis fungoides, a subtype of CTCL. Read More

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Cutaneous Involvement of Angioimmunoblastic T-Cell Lymphoma Masquerading as B-Cell Reactive Lymphoid Hyperplasia.

Am J Dermatopathol 2022 Apr;44(4):e41-e45

Departments of Dermatology, and.

Abstract: A 59-year-old woman presented with a persistent eruption manifested as multiple agminated miliary facial papules. Histopathological examination showed prominent nodular dermal lymphoid infiltrates with hyperplastic follicles that were initially interpreted as B-cell reactive lymphoid hyperplasia. Several years later, an additional biopsy showed a dense perifollicular infiltrate with reactive primary and secondary follicles. Read More

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Diagnosis of Lyme Borreliosis With a Novel, Seminested Real-Time Polymerase Chain Reaction Targeting the 5S-23S Intergenic Spacer Region: Clinical Features, Histopathology, and Immunophenotype in 44 Patients.

Am J Dermatopathol 2022 May;44(5):338-347

Dermatologikum Hamburg, Hamburg, Germany; and.

Abstract: Lyme borreliosis (LB) is the most common tick-borne infection in Europe and North America. Polymerase chain reaction (PCR) is an important tool to confirm the diagnosis, but not always successful, especially when organisms are sparse. We developed a novel, seminested real-time PCR assay [target: 5S-23S intergenic spacer region (IGS)] and compared it with 3 well-established conventional PCR assays (IGS/OspA/real-time IGS) on 596 formalin-fixed, paraffin-embedded routine skin biopsies. Read More

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Cutaneous B cell lymphomas: standards in diagnostic and clinical work-up. Hints, pitfalls and recent advances.

Histopathology 2022 Jan;80(1):184-195

Department of Dermatology and Allergology, University Hospitals Schleswig-Holstein, Christian-Albrecht-University, Kiel, Germany.

This review focuses upon the pragmatic diagnostic approach of suspicious B cell infiltrations in the skin and lists the necessary histopathological and molecular tools for a thorough work-up. We start with the description of different histopathological patterns of cutaneous B cell infiltrations and recommend pattern-dependent immunohistochemical staining algorithms for further differential diagnosis. A summarised description of the current World Health Organisation (WHO) subtypes of primary cutaneous B cell lymphomas highlighting their most relevant clinical, histopathological and molecular features is included. Read More

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January 2022

Cutaneous B cell pseudolymphoma treated with rituximab and methotrexate.

Dermatol Online J 2021 Sep 15;27(9). Epub 2021 Sep 15.

Department of Dermatology, Mayo Clinic, Scottsdale, AZ.

Cutaneous B cell pseudolymphoma (CBPL), or cutaneous lymphoid hyperplasia, is the most common pseudolymphoma. It typically responds well to local treatment and follows a benign course. Herein, we describe the unique case of a patient with CBPL that was refractory to a variety of treatments, with subsequent response to rituximab followed by methotrexate. Read More

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September 2021

Dermatoscopy of nodular/plaque-type primary cutaneous T- and B-cell lymphomas: A retrospective comparative study with pseudolymphomas and tumoral/inflammatory mimickers by the International Dermoscopy Society.

J Am Acad Dermatol 2022 04 23;86(4):774-781. Epub 2021 Oct 23.

Institute of Dermatology, Department of Medicine, University of Udine, Udine, Italy.

Background: Limited data on dermatoscopy of nodular/plaque-type T-/B-cell primary cutaneous lymphomas (PCLs) is available.

Objective: To describe dermatoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences according to histologic subtypes.

Methods: Participants were invited to join this retrospective, multicenter case-control study by submitting histologically/immunohistochemically confirmed instances of nodular/plaque-type PCLs and controls. Read More

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Clonal cutaneous and neurosyphilis: A pitfall in pseudolymphoma diagnosis.

J Cutan Pathol 2022 Mar 5;49(3):288-292. Epub 2021 Nov 5.

Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA.

Syphilis is a sexually transmitted infectious disease caused by the bacterium Treponema pallidum and can cause a wide variety of cutaneous manifestations, most commonly, a papulosquamous eruption of the trunk and extremities. Treatment with penicillin is curative. We report a case of a 69-year-old man who presented with recent onset of blurry vision and a nonpainful, nonpruritic eruption of pink-to-violaceous dermal nodules on his upper trunk and upper extremities. Read More

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Lymphocytoma cutis (cutaneous B-cell pseudolymphoma): study of 102 cases with emphasis on the histological characteristics and immunohistochemistry of the miliarial type.

Int J Dermatol 2022 Mar 19;61(3):316-323. Epub 2021 Sep 19.

División de Investigación Médica, UMAE Hospital de Pediatría CMNO, IMSS, Guadalajara, Jalisco, México.

Background: Lymphocytoma cutis (LC) is a benign reactive lymphoproliferative B-cell process. It has two variants: localized type with solitary lesions and miliarial type with numerous lesions. The objective was to investigate the characteristics of LC with emphasis on the miliarial type. Read More

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Ultrasonography of cutaneous nodular pseudolymphoma at 18 and 71 MHz.

Skin Res Technol 2022 Jan 29;28(1):176-179. Epub 2021 Aug 29.

Department of Pathology, Faculty of Medicine, Hospital Clínico Universidad de Chile, Universidad de Chile, Santiago, Chile.

Cutaneous pseudolymphomas are reactive lymphoproliferations. The most frequent type is nodular pseudolymphoma, and to date, their ultrasonographic appearance has not been reported. We reviewed the ultrasound images of histologically confirmed nodular types of pseudolymphomas studied with 18 and 71 MHz linear probes. Read More

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January 2022

Clinical and Dermoscopic Features of a Case of Idiopathic T-Cell Pseudolymphoma.

Indian Dermatol Online J 2021 Jul-Aug;12(4):583-586. Epub 2021 Jun 20.

Department of Pathology, Venereology, and Leprosy, JIPMER, Puducherry, India.

Cutaneous pseudolymphomas are a group of benign lymphocyte-rich infiltrates that can mimic cutaneous lymphomas either clinically and/or histologically. Idiopathic T-cell pseudolymphoma (TCPL) usually presents as a solitary nodule or plaque on the trunk or head. A clinicopathologic correlation is mandatory to arrive at a final diagnosis and rule out true lymphomas. Read More

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Cutaneous lymphoid hyperplasia developing on the site of a positive intradermal allergy test to cefotetan.

Indian J Dermatol Venereol Leprol 2021 Sep-Oct;87(5):748

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

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January 2022

Cutaneous pseudolymphoma related to violet tattoo ink successfully treated with intralesional corticosteroid.

Ital J Dermatol Venerol 2021 Jul 20. Epub 2021 Jul 20.

Dermatology IRCCS Policlinico di Sant'Orsola, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy.

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Histopathologic Spectrum of Findings Associated With Tattoos: Multicenter Study Series of 230 Cases.

Am J Dermatopathol 2021 Aug;43(8):543-553

Pathologist, Pathology Department, Hospital University German Trias I Pujol, Barcelona, Spain.

Importance: Reactions to tattoo may simulate common dermatosis or skin neoplasms. Histopathology allows diagnosis and helps determining the level and degree of inflammation associated, consequently orientating treatment.

Objective: To describe the histological features found in biopsies of cutaneous reactions to tattoo. Read More

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Analysis of clonality in cutaneous B-cell lymphoma and B-cell pseudolymphoma using skin flow cytometry: Comparison of immunophenotyping and gene rearrangement studies.

J Dermatol 2022 Feb 14;49(2):246-252. Epub 2021 Jul 14.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

To identify clonal neoplastic cells in skin affected by B-cell lymphoma using skin flow cytometry (FCM) techniques, we investigated light-chain restriction using skin FCM with clonality assessed by polymerase chain reaction and light-chain restriction by in situ hybridization (ISH). We retrospectively analyzed 16 cases of B-cell lymphoma with cutaneous involvement: primary cutaneous diffuse large B-cell lymphoma, leg type (pcDLBCL-LT) (n = 7), DLBCL-not otherwise specified (DLBCL-NOS) (n = 6), primary cutaneous follicle center lymphoma (pcFCL) (n = 1), and follicular lymphoma (n = 2), as well as cutaneous B-cell pseudolymphoma (n = 9). Results of skin FCM light-chain restriction analyses were compared with immunoglobulin H (IgH) gene rearrangement and κ/λ ISH findings. Read More

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February 2022

Cutaneous pseudolymphoma induced by tumor necrosis factor-alpha inhibitors.

Masaki Yokota

Int J Dermatol 2021 Jul 9. Epub 2021 Jul 9.

Department of Dermatology, Toho University Sakura Medical Center, Sakura, Japan.

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Cutaneous pseudolymphoma: A clinicopathological study and immunohistochemical patterns.

Caspian J Intern Med 2021 Apr;12(3):283-289

Department of pathology, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Cutaneous pseudolymphoma can histologically and clinically simulate various types of cutaneous lymphoma. We conducted the current study to evaluate the clinicopathological and immunohistochemical (IHC) aspects of cutaneous pseudolymphoma (PSL).

Methods: 30 cases of cutaneous PSL were selected from the archives of 2013-2017 in Shahid Faghihi Hospital pathology lab, Shiraz University of Medical Sciences. Read More

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Diffuse adverse cutaneous reactions induced by zoledronic acid administration: a case report : Eruptions cutanées diffuses induites par l'administration de l'acide zolédronique.

Osteoporos Int 2021 Dec 3;32(12):2583-2586. Epub 2021 Jun 3.

Rheumatology department, Ibn Rochd University Hospital, Hassan II University of Medecine and Pharmacy, Casablanca, Morocco.

Zoledronic acid, an amino-bisphosphonate, is an antiresorptive drug given intravenously. It is commonly used for the treatment of severe postmenopausal osteoporosis, and it is also used for other types of osteoporosis, management of bone metastasis, multiple myeloma, hypercalcemia, and Paget's disease. The use varies according to these diseases. Read More

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December 2021

Cutaneous Pseudolymphoma With Langerhans Cell Hyperplasia-A Rare Case With Clinical Presentation Mimicking Malignancy and Potential Diagnostic Pitfall.

Am J Dermatopathol 2021 Dec;43(12):e280-e284

Department of Dermatology, Changhua Christian Hospital, Changhua, Taiwan.

Abstract: We describe a rare case of cutaneous pseudolymphoma with Langerhans cell hyperplasia. An 84-year-old female patient presented with erythematous and pernicious-looking plaques on her scalp that had been present for months. Histologically, lymphoid follicles consisting of mixed-type lymphocytes and Langerhans cells were aggregated focally. Read More

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December 2021

The Puzzle of Papules Over Face and Extrafacial Areas: A Rare Case of Disseminated Idiopathic T-Cell Pseudolymphoma.

Indian Dermatol Online J 2021 Mar-Apr;12(2):312-315. Epub 2021 Mar 2.

Department of Dermato-Venereo-Leprology, Government Medical College, Nagpur, Maharashtra, India.

Papular lesions over face have a wide range of differential diagnoses. The clinical differentiation among these is difficult and often requires clinicopathological correlation. We hereby report the case of a 28 year old female presenting with numerous skin colored papular lesions over face, pinna and upper limbs. Read More

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Tattoos - more than just colored skin? Searching for tattoo allergens.

J Dtsch Dermatol Ges 2021 05 6;19(5):657-669. Epub 2021 May 6.

Department of Dermatology and Allergology, University of Regensburg, Regensburg, Germany.

During tattooing, a high amount of ink is injected into the skin. Tattoo inks contain numerous substances such as the coloring pigments, impurities, solvents, emulsifiers, and preservatives. Black amorphous carbon particles (carbon black), white titanium dioxide, azo or polycyclic pigments create all varieties of color shades in the visible spectrum. Read More

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Differential diagnoses of pseudolymphomatous folliculitis: considerations as regards one case.

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK

Pseudolymphomatous folliculitis (PLF) is a rare disease of cutaneous lymphoid hyperplasia, with a low index of clinical suspicion. We present the clinical case of a 19-year-old male patient, with a solitary violet erythematous nodule of 6 months of evolution, located in the right infraorbital region, without presenting another symptomatology. Histopathological examination showed a lymphocytic infiltrate that surrounds the hair follicles, sebaceous and sweat glands that focally destroy their basement membrane. Read More

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[Cutaneous pseudolymphoma after hirudotherapy : Case report and review].

Hautarzt 2022 Feb 21;73(2):152-155. Epub 2021 Apr 21.

Hautklinik, Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.

The term cutaneous pseudolymphoma (C-PSL) is defined in the literature as a benign, reactive lymphoproliferation that clinically and/or histopathologically imitates cutaneous lymphoma. The exact etiopathogenesis has not been fully elucidated to date. A distinction is made between primary, idiopathic PSL without an identifiable cause and secondary PSL with a known stimulus. Read More

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February 2022

Shall we exclude parapsoriasis from the medical vocabulary?

J Cutan Pathol 2021 Jul 14;48(7):833-836. Epub 2021 Mar 14.

Department of Pathology, Botucatu Medical School, Paulista State University (UNESP), Botucatu, São Paulo, Brazil.

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EBER in situ hybridization in subcutaneous aluminum granulomas/lymphoid hyperplasia: A diagnostic clue to differentiate injection-associated lymphoid hyperplasia from other forms of pseudolymphomas and cutaneous lymphomas.

J Cutan Pathol 2021 May 11;48(5):625-631. Epub 2021 Feb 11.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Background: Subcutaneous vaccination or desensitization may induce persistent nodules at the injection sites. Without the knowledge of prior injection, histopathological work-up may be challenging.

Objective: Aim of this study was to contribute to the histopathological work-up of unclear subcutaneous nodules, especially their differentiation from cutaneous lymphoma. Read More

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A case of coexisting Bowen's disease and cutaneous pseudolymphoma.

Eur J Dermatol 2020 Dec;30(6):744-746

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.

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December 2020