DIAGNOSIS OF ENDOCRINE DISEASE: Differentiation of Pathologic/Neoplastic Hypercortisolism (Cushing Syndrome) from Physiologic/Non-neoplastic Hypercortisolism (formerly known as Pseudo-Cushing Syndrome).
Eur J Endocrinol 2017 Feb 8. Epub 2017 Feb 8.
H Raff, Endocrine Research Lab, Aurora St. Luke's Medical Center, Milwaukee, 53215, United States
Endogenous hypercortisolism (Cushing syndrome) usually implies the presence of a pathologic condition caused by either an ACTH-secreting neoplasm or autonomous cortisol secretion from a benign or malignant adrenal neoplasm. However, sustained or intermittent hypercortisolism may also accompany many medical disorders that stimulate physiologic/non-neoplastic activation of the HPA axis (formerly known as pseudo-Cushing syndrome); these two entities may share indistinguishable clinical and biochemical features. A thorough history and physical examination is often the best (and sometimes only) way to exclude pathologic/neoplastic hypercortisolism. Read More