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    659 results match your criteria Pruritus and Systemic Disease

    1 OF 14

    [Pruritus of the scalp : Simply pulling out your hair?]
    Hautarzt 2017 Apr 12. Epub 2017 Apr 12.
    Abteilung Klinische Sozialmedizin, Schwerpunkt: Berufs- und Umweltdermatologie, Universitätsklinikum, Ruprecht-Karls-Universität Heidelberg, Voßstr. 2, 69115, Heidelberg, Deutschland.
    Scalp pruritus is a frequent symptom and can be caused by dermatologic diseases, contact allergies, neurologic, psychiatric/somatoform and systemic diseases. In daily clinical practice scalp pruritus is a diagnostic and therapeutic challenge, especially if no detectable lesions are present. A detailed patient history and the inspection of scalp and the skin of the whole body are essential for diagnosis. Read More

    Association of Dermatoses with Duration and Quantum of Alcohol Intake: A Comparative Cross-sectional Study.
    Indian J Dermatol 2017 Mar-Apr;62(2):184-190
    Department of Dermatology, Dr. D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India.
    Background: Chronic alcohol intake impacts skin directly, through organ dysfunction or by modifying preexisting dermatoses. However, dermatoses afflicting chronic alcoholics figure in a few studies only.

    Aim: This study aims to correlate the spectrum of dermatoses in chronic alcoholics with the quantum/duration of alcohol intake and raised liver transaminases. Read More

    The efficacy and safety of intravenous lidocaine for analgesia in the older adult: a literature review.
    Br J Pain 2017 Feb 24;11(1):23-31. Epub 2016 Oct 24.
    North Devon District Hospital, Barnstaple, UK.
    Opioids remain the mainstay of analgesia for the treatment of moderate to severe acute pain. Even in the young, the use of opioids can be associated with an increased incidence of post-operative complications such as respiratory depression, vomiting, pruritus, excessive sedation, slowing of gastrointestinal function, and urinary retention. The need to manage acute pain in the older patient is becoming more common as the population ages, and increasingly older patients are undergoing more major surgery. Read More

    [Pathophysiology of atopic blepharokeratoconjunctivitis].
    Ophthalmologe 2017 Mar 30. Epub 2017 Mar 30.
    Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
    Atopic dermatitis (AD) is a systemic inflammatory disease, which is characterized by pronounced eczema and pruritus. In addition to the involvement of the entire integument, the periocular lid skin and the surface of the eye are frequently involved. Ocular involvement may occur solely without dermatitis of facial or body skin. Read More

    Sublingual immunotherapy tablets as a disease-modifying add-on treatment option to pharmacotherapy for allergic rhinitis and asthma.
    Postgrad Med 2017 Mar 27:1-9. Epub 2017 Mar 27.
    e Merck & Co., Inc ., Kenilworth , NJ , USA.
    Allergic rhinitis (AR) with or without conjunctivitis (AR/C) is associated with a significant health and economic burden, and is often accompanied by asthma. Pharmacotherapies are the mainstay treatment options for AR and asthma, but guidelines also recommend allergy immunotherapy (AIT). Unlike pharmacotherapies, AIT has the ability to modify the underlying immunologic mechanisms of AR and asthma with the potential for long-term benefits after treatment is discontinued. Read More

    Clinical Signs, Staphylococcus and Atopic Eczema-Related Seromarkers.
    Molecules 2017 Feb 14;22(2). Epub 2017 Feb 14.
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.
    Childhood eczema or atopic dermatitis (AD) is a distressing disease associated with pruritus, sleep disturbance, impaired quality of life and Staphylococcus aureus isolation. The pathophysiology of AD is complex and various seromarkers of immunity are involved. We investigated if anti-staphylococcal enterotoxin IgE (anti-SE), selected seromarkers of T regulatory (Treg), T helper (Th) and antigen-presenting cells (APC) are associated with clinical signs of disease severity and quality of life. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    A Phase 1 clinical trial demonstrates nfP2X7 targeted antibodies provide a novel, safe and tolerable topical therapy for BCC.
    Br J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Biosceptre (Aust) Pty Ltd, 11 Julius Avenue, North Ryde, NSW 2113, Australia.
    Background: Expression of P2X7 , an ATP gated calcium channel, increases cancer cell proliferation and invasiveness. A variant of P2X7 (termed nfP2X7 ), in which a normally hidden epitope (E200) is exposed for antibody binding, is observed in a variety of different cancers.

    Objectives: To investigate the safety, tolerability and pharmacokinetics and assess indicative efficacy of a novel antibody ointment as a therapeutic for BCC. Read More

    Clinical Features, Response to Treatment, and Outcomes of IgG4-Related Sclerosing Cholangitis.
    Clin Gastroenterol Hepatol 2017 Jan 20. Epub 2017 Jan 20.
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
    Background & Aims: Immunoglobulin G4 sclerosing cholangitis (IgG4-SC) is a biliary tract manifestation of IgG4-related systemic disease. We investigated the demographics, clinical features at presentation, treatment response, and outcomes of IgG4-SC using data from a large-scale survey in Japan.

    Methods: We performed a retrospective cohort study of 527 patients with IgG4-SC (436 female; median age, 66. Read More

    Clinical features of shiitake dermatitis: a systematic review.
    Int J Dermatol 2017 Jan 4. Epub 2017 Jan 4.
    Department of Dermatology, Mayo Clinic Florida, Jacksonville, FL, USA.
    Shiitake dermatitis is a rare cutaneous reaction to lentinan, a polysaccharide component in the cell walls of shiitake mushrooms (Lentinula edodes). Herein, we systematically review the case report and case series English-language literature on shiitake dermatitis, which refers to a total of 50 patients (38 males, 12 females; mean age: 44.58 years). Read More

    Systemic Mastocytosis Causing Refractory Pruritus in a Liver Disease Patient.
    ACG Case Rep J 2016 Aug 23;3(4):e152. Epub 2016 Nov 23.
    Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR.
    Systemic mastocytosis (SM) results from clonal, neoplastic proliferation of abnormal mast cells. Patients become susceptible to itching, urticaria, and anaphylactic shock, which occurs due to histamine release from mast cells. SM may coexist alongside other systemic diseases, thus confounding the overall clinical presentation. Read More

    [Cutaneous manifestations in renal diseases].
    Hautarzt 2016 Dec;67(12):960-969
    Dermatologische Abteilung, Donauspital, Langobardenstr. 122, 1220, Wien, Österreich.
    In addition to general skin changes like pallor or dryness and the frequent, often excruciating nephrogenic pruritus, specific diseases in patients with renal failure may occur. Acquired perforating dermatoses are usually also highly pruritic. Calciphylaxis is a severe disease with poor prognosis. Read More

    [Diffuse cutaneous mastocytosis of an infant: A case report].
    Arch Pediatr 2016 Nov 23;23(11):1150-1152. Epub 2016 Sep 23.
    Service de dermatologie, centre hospitalier universitaire Ibn Sina, rue Famfdal Cherkaoui, BP 6527, 10000 Rabat, Maroc.
    Mastocytosis is a group of diseases related to abnormal accumulation and proliferation of mast cells in one or more organs. They may be associated with an acquired point mutation and the activation of the receptor tyrosine-kinase c-KIT of CFS (mast cell growth factor). The clinical manifestations are varied and secondary to the release of mast cell mediators and/or infiltration of various organs. Read More

    Small animal disease surveillance: pruritus, and coagulase-positive staphylococci.
    Vet Rec 2016 Oct;179(14):352-355
    BSAVA, Woodrow House, 1 Telford Way, Waterwells Business Park, Quedgeley, Gloucestershire GL2 2AB, UK.
    Presentation for pruritus comprised 6.5 per cent, 3.6 per cent and 2. Read More

    African American race associated with body image dissatisfaction among patients with systemic sclerosis.
    Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):70-73. Epub 2016 May 10.
    Georgetown University Medical Center, Washington, DC, USA.
    Objectives: Studies have shown a high degree of body image dissatisfaction among patients with systemic sclerosis (SSc). We aimed to identify demographic and phenotypic characteristics that correlate with body image dissatisfaction.

    Methods: Ninety-eight patients with SSc were recruited from Georgetown University Medical Center 2003-2004. Read More

    Pruritus in selected dermatoses.
    Eur Rev Med Pharmacol Sci 2016 Sep;20(17):3628-41
    Department of Dermatology, University of Medical Sciences, Poznan, Poland.
    Pruritus is a natural defence mechanism of the body and creates the scratch reflex as a defensive reaction to potentially dangerous environmental factors. Together with pain, pruritus is a type of superficial sensory experience. Pruritus is a symptom often experienced both in healthy subjects and in those who have symptoms of a disease. Read More

    Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment.
    Dermatol Pract Concept 2016 Jul 31;6(3):31-8. Epub 2016 Jul 31.
    Department of Dermatology, University of California San Diego, San Diego, California.
    Background: Mastocytosis is either cutaneous (with skin-limited proliferation of mast cells) or systemic (with mast cells in extracutaneous sites). The onset of solitary mastocytoma in an adult is rare.

    Purpose: A woman with the new onset of solitary mastocytoma is described. Read More

    Clinical Efficacy of Romidepsin in Tumor Stage and Folliculotropic Mycosis Fungoides.
    Clin Lymphoma Myeloma Leuk 2016 Nov 10;16(11):637-643. Epub 2016 Aug 10.
    Kings College London, St John's Institute of Dermatology, London, United Kingdom.
    Background: Tumor stage and folliculotropic mycosis fungoides are uncommon subtypes of cutaneous T-cell lymphoma (CTCL) with an aggressive disease course. Romidepsin is a histone deacetylase inhibitor approved by the US Food and Drug Administration for patients with CTCL who have received ≥ 1 previous systemic therapy. In the present study, we examined the efficacy and safety of romidepsin in patients from the pivotal, single-arm, open-label, phase II study of relapsed or refractory CTCL with cutaneous tumors and/or folliculotropic disease involvement. Read More

    Induction of Immune Response after Allogeneic Wilms' Tumor 1 Dendritic Cell Vaccination and Donor Lymphocyte Infusion in Patients with Hematologic Malignancies and Post-Transplantation Relapse.
    Biol Blood Marrow Transplant 2016 Dec 12;22(12):2149-2154. Epub 2016 Sep 12.
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
    Relapse of hematologic malignancies is the primary cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HCT). Treatment for post-HCT relapse using donor lymphocyte infusion (DLI) has limited utility, particularly in the setting of acute leukemia, and can result in the development of graft-versus-host disease (GVHD). The Wilms' tumor 1 (WT1) gene product is a tumor-associated antigen that is expressed in acute leukemia and other hematologic malignancies, with limited expression in normal tissues. Read More

    Inducible urticaria: Case series and literature review.
    Biomedica 2016 Mar 3;36(1):10-21. Epub 2016 Mar 3.
    Grupo de Alergología Clínica y Experimental (GACE), IPS Universitaria, Universidad de Antioquia, Medellín, Colombia.
    Inducible urticaria is a heterogeneous group of skin disorders characterized by the appearance of wheals, pruritus and/or angioedema, sometimes accompanied by systemic symptoms caused by innocuous stimuli (cold, heat, pressure, etc.). This group of disorders compromises people's quality of life and most of the literature in this regard comes from case reports and case series since its epidemiology has been poorly studied and some cases are very rare. Read More

    Spinal dorsal horn astrocytes: New players in chronic itch.
    Allergol Int 2017 Jan 30;66(1):31-35. Epub 2016 Aug 30.
    Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:
    Chronic itch is a debilitating symptom of inflammatory skin conditions, such as atopic dermatitis, and systemic diseases, for which existing treatment is largely ineffective. Recent studies have revealed the selective neuronal pathways that are involved in itch sensations; however, the mechanisms by which itch turns into a pathological chronic state are poorly understood. Recent advances in our understanding of the mechanisms producing chronic itch have been made by defining causal roles for astrocytes in the spinal dorsal horn in mouse models of chronic itch including atopic dermatitis. Read More

    Pruritus Reduction with Systemic Anti-lymphoma Treatments in Patients with Cutaneous T Cell Lymphoma: A Narrative Review.
    Dermatol Ther (Heidelb) 2016 Dec 2;6(4):579-595. Epub 2016 Sep 2.
    University of Arkansas, Little Rock, AR, USA.
    Cutaneous T-cell lymphomas (CTCL) are a heterogeneous and relatively rare group of non-Hodgkin lymphomas arising from neoplastic skin-homing memory T cells. There is no known cure for CTCL, and current treatments focus on achieving and maintaining remission, controlling symptoms, limiting toxicities and maintaining or improving quality of life. Patients with CTCL often suffer from pruritus (itching), which can be debilitating and can have a significant impact on physical well-being and quality of life. Read More

    Itch Management in Childhood.
    Curr Probl Dermatol 2016 23;50:173-91. Epub 2016 Aug 23.
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.
    Itch in children is a very common symptom and is mainly related to a skin disease rather than an underlying systemic disorder. The most common dermatoses include atopic dermatitis, contact dermatitis, insect bites, scabies, and pediculosis capitis. There are specific diagnostic patterns which require the evaluation of a careful history and dermatological examination. Read More

    Paraneoplastic Itch Management.
    Curr Probl Dermatol 2016 23;50:149-54. Epub 2016 Aug 23.
    Paraneoplastic itch occurs as the result of a systemic reaction to an underlying malignancy. Paraneoplastic itch is most commonly associated with lymphoproliferative malignancies and solid tumors that result in cholestasis. Paraneoplastic itch may occur in the absence of a primary rash or in association with dermatologic conditions such as erythroderma, acanthosis nigricans, dermatomyositis, Grover's disease, and eruptive seborrheic keratosis. Read More

    Prurigo Nodularis Management.
    Curr Probl Dermatol 2016 23;50:94-101. Epub 2016 Aug 23.
    Characterized by the clinical presentation of individual to multiple symmetrically distributed, hyperkeratotic, and intensely itchy papules and nodules, prurigo nodularis (PN) is a rare disease that emerges in patients with chronic pruritus due to continuous scratching over a long period of time. The itching and scratching of the lesions contribute to the vicious cycle that makes this disease difficult to treat, thus reducing the quality of life of affected patients. The pathogenesis of PN is ambiguous, although immunoneuronal crosstalk is implicated. Read More

    Diagnostic Procedures of Itch.
    Curr Probl Dermatol 2016 23;50:24-8. Epub 2016 Aug 23.
    A complex and multifactorial pathogenesis of itch makes the proper diagnosis of underlying disease a difficult and challenging clinical problem. The examination of every patient with itch should be started by gathering an accurate history. During the anamnesis it is important to obtain data about the beginning of the appearance of symptoms, its location, diurnal variation, and the factors influencing itch perception. Read More

    Treatment of ichthyosis lamellaris using a series of herbal skin care products family.
    J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):65-72
    Chair of Dermatology, University of Rome “G. Marconi” Rome, Italy.
    Lamellar ichthyosis (LI) is a genetically heterogeneous group of disorders of keratinization that are inherited in an autosomal recessive fashion, occurring in approximately 1 in 300,000 live births. The treatment of the large, dark, plate-like scales that characterize the classic manifestation of the disease are still a challenge. The aim of this study was to evaluate the efficacy and tolerability of Dr. Read More

    Current and Emerging Therapies for Itch Management in Psoriasis.
    Am J Clin Dermatol 2016 Dec;17(6):617-624
    Department of Dermatology and Itch Center, Lewis Katz School of Medicine at Temple University, 3322 North Broad Street, Medical Office Building, Suite 212, Philadelphia, PA, 19140, USA.
    Pruritus is a common and significant symptom among patients with psoriasis. Pruritus is often present beyond the borders of psoriatic plaques, and frequently affects the scalp and genital regions. Psoriatic itch may be severe and can profoundly affect quality of life and sleep, even in the context of mild-to-moderate disease. Read More

    DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: case report
    Int J Clin Pharmacol Ther 2016 Oct;54(10):808-15
    Objective: To report a rare case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by antituberculosis (TB) drugs, which progressed to acute generalized exanthematous pustulosis (AGEP) after moxifloxacin treatment.

    Case Summary: A 25-year-old female was hospitalized for dyspnea and dizziness. She had a history of TB and experienced rifampin-induced skin rash. Read More

    UVA1 phototherapy in the treatment of palmoplantar pustulosis: a pilot prospective study.
    Lasers Med Sci 2016 Nov 20;31(8):1641-1643. Epub 2016 Jul 20.
    Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
    Palmoplantar pustulosis (PPP) is recalcitrant to traditional topical and systemic therapies. Ultraviolet A1 (UVA1) phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of PPP. The purpose of this study was to evaluate the efficacy and safety of UVA1 therapy for the treatment of PPP. Read More

    New drugs in cutaneous T-cell lymphomas.
    Curr Opin Oncol 2016 Sep;28(5):384-9
    Department Dermatology, University Hospital Birmingham, Birmingham, United Kingdom.
    Purpose Of Review: Currently, there are no curative therapies for cutaneous T-cell lymphoma (CTCL), and consecutive treatments tend to be given until loss of response. There is an urgent need for new and improved therapies in CTCL to treat symptoms such as pruritus and painful skin lesions and prolong survival. This article reviews new drugs available for CTCL. Read More

    Advancement in management of epidermolysis bullosa.
    Curr Opin Pediatr 2016 Aug;28(4):507-16
    Department of Dermatology, Stanford University, Stanford, California, USA.
    Purpose Of Review: Epidermolysis bullosa is a hereditary skin disorder characterized by skin fragility. However, the disease can manifest in many different organ systems, therefore children born with epidermolysis bullosa may have life long, complex medical needs. In this review, we will use a system-based approach to highlight important aspects of disease management and recent advancements in each of the areas. Read More

    Effects of systematic nursing instruction on a low-phosphorus diet, serum phosphorus level and pruritus of patients on haemodialysis.
    J Clin Nurs 2017 Feb 15;26(3-4):485-494. Epub 2016 Aug 15.
    Master Program in Long-term Care and School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
    Aims And Objectives: To investigate the effectiveness of systematic nursing instruction on a low-phosphorus diet, serum phosphorus level and pruritus of haemodialysis patients.

    Background: A high number of end-stage renal disease patients on haemodialysis are bothered by pruritus. Hyperphosphataemia was reported to be related to pruritus. Read More

    [Pruritus in systemic diseases : Common and rare etiologies].
    Hautarzt 2016 Aug;67(8):606-14
    DKD Helios Kliniken Wiesbaden, Aukammallee 33, 65191, Wiesbaden, Deutschland.
    Chronic pruritus is a symptom of various internal disorders. In contrast to dermatological diseases, pruritus does not present with primary skin alterations in these patients. However, intense scratching may cause secondary skin changes such as abrasion, excoriation, prurigo nodularis, or in rare cases even scaring. Read More

    A Comparative Study on the Adverse Reactions of Purified Chick Embryo Cell Vaccine (PCECV) and Purified Vero Cell Rabies Vaccine (PVRV).
    Arch Iran Med 2016 Jul;19(7):502-7
    Center of Disease Control (CDC), Ministry of Health, Treatment and Medical Education, Tehran, Iran.
    Objective: Human rabies is preventable by prompt application of post-exposure prophylaxis (PEP). The aim of this study was to compare the adverse reactions of purified vero cell rabies vaccine (PVRV) with purified chick embryo cell vaccine (PCECV) vaccination for the PEP.

    Methods: In this double blind clinical trial study, 1449 people bitten by animals (279 females), were recruited from 9 different cities of Iran, and randomly assigned to receive intramuscular injections of the PVRV (n = 702) and PCECV (n = 747) vaccines in 5-dose regimen. Read More

    Acquired Reactive Perforating Dermatosis is a Variant of Prurigo Nodularis.
    Acta Derm Venereol 2017 Feb;97(2):249-254
    Center for Chronic Pruritus, Department of Dermatology, University Hospital Münster, Münster, Germany.
    Patients with chronic pruritus may develop scratch-induced lesions with elevated borders and central necrosis. This so-called umbilicated type of prurigo (UP) is rare and is assumed to develop preferentially in the context of metabolic diseases. The aim of this study was to characterize UP in its clinical and histological dimension. Read More

    [Small fiber neuropathy as a possible cause for chronic pruritus].
    Hautarzt 2016 Aug;67(8):615-21
    Kompetenzzentrum Chronischer Pruritus (KCP), Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland.
    Background: Small fiber neuropathy arises from injury of small C and Aδ fibers and leads to pruritus as well as positive (pain, burning, tingling or stinging sensation) and negative neurological (numbness) symptoms.

    Objectives: To give an overview on small fiber neuropathy as a cause for chronic pruritus, the diagnostic approach to this condition, and therapeutic options.

    Materials And Methods: A literature search using the terms "small fiber neuropathy", "pruritus", "itch", and "pain" was performed. Read More

    Chronic Pruritus and Connective Tissue Disorders: Review, Gaps, and Future Directions.
    Am J Clin Dermatol 2016 Oct;17(5):445-449
    Department of Dermatology and Itch Center, Lewis Katz Medical School Temple University, 3322 North Broad Street, Medical Office Building, Suite 212, Philadelphia, PA, 19140, USA.
    Chronic itch is a common skin manifestation in many connective tissue diseases. However, the cause of chronic itch in these diseases is still not fully understood. The complex, and in some cases incomplete understanding of, pathogenesis in each condition makes it difficult to target specific mediators of chronic itch. Read More

    Health-related quality of life in patients with psoriasis: a systematic review of the European literature.
    Qual Life Res 2016 Nov 3;25(11):2739-2754. Epub 2016 Jun 3.
    Outcomes'10, Castellón, Spain.
    Purpose: To summarize the data published over the last 5 years in the European Union related to the health-related quality of life (HRQoL) of patients with psoriasis and its conditioning factors.

    Methods: International electronic databases and gray literature were searched to identify studies conducted on patient-reported outcomes in patients with psoriasis, published in Europe between January 1, 2009 and December 31, 2013. Bibliographic references were hand-searched. Read More

    Phase I Study of Lenalidomide and Sorafenib in Patients With Advanced Hepatocellular Carcinoma.
    Oncologist 2016 Jun 2;21(6):664-5. Epub 2016 Jun 2.
    University of Washington School of Medicine, Seattle, Washington, USA.
    Lessons Learned: Combination therapies in patients with hepatocellular carcinoma can be associated with overlapping toxicity and are therefore poorly tolerated.Using sorafenib at the maximum tolerated dose can lead to a higher incidence of toxicities. Consequently, combination studies might evaluate sorafenib at alternative schedules or doses to improve tolerance, recognizing this could affect sorafenib efficacy. Read More

    Dupilumab, A Monoclonal Antibody for Atopic Dermatitis: A Review of Current Literature.
    Skin Therapy Lett 2016 Mar;21(2):1-5
    K. Papp Clinical Research, Waterloo, ON, Canada; Probity Medical Research, Waterloo, ON Canada.
    Atopic dermatitis results when aberrant barrier function and immune activation occur within the skin. Standard therapies for atopic dermatitis have fallen short, prompting efforts to discover novel therapeutics for this disease. Of these, dupilumab, a fully human monoclonal antibody that inhibits the actions of both IL-4 and IL-13, has shown the greatest promise. Read More

    Chronic Pruritus in the Absence of Skin Disease: Pathophysiology, Diagnosis and Treatment.
    Am J Clin Dermatol 2016 Aug;17(4):337-48
    Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Von-Esmarch-Str. 58, 48149, Münster, Germany.
    Chronic pruritus arises not only from dermatoses, but also, in up to half of cases, from extracutaneous origins. A multitude of systemic, neurological, psychiatric, and somatoform conditions are associated with pruritus in the absence of skin disease. Moreover, pruritus is a frequently observed side effect of many drugs. Read More

    Addressing treatment challenges in atopic dermatitis with novel topical therapies.
    J Dermatolog Treat 2016 Nov 11;27(6):568-576. Epub 2016 May 11.
    c Department of Dermatology and Itch Center, Lewis Katz School of Medicine , Temple University , Philadelphia , PA , USA.
    Atopic dermatitis (AD), a chronic inflammatory skin disease affecting children and adults, presents as mild-to-moderate disease in the majority of patients. Pruritus, one of the key diagnostic criteria for AD, is associated with reduced quality of life and disease aggravation. Current treatments include emollients and topical pharmaceutical agents. Read More

    Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor.
    Acta Dermatovenerol Croat 2016 Apr;24(1):70-2
    Daška Štulhofer Buzina, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;
    Dear Editor, Inhibition of the epidermal growth factor receptor (EGFR) is a new strategy in treatment of a variety of solid tumors, such as colorectal carcinoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and pancreatic cancer (1). Cetuximab is a chimeric human-murine monoclonal antibody against EGFR. Cutaneous side effects are the most common adverse reactions occurring during epidermal growth factor receptor inhibitors (EGFRI) therapy. Read More

    Systemic and spinal administration of FAAH, MAGL inhibitors and dual FAAH/MAGL inhibitors produce antipruritic effect in mice.
    Arch Dermatol Res 2016 Jul 28;308(5):335-45. Epub 2016 Apr 28.
    Department of Pharmacology, Drug Discovery and Research Center, Gulhane Academy of Medicine, Etlik, 06018, Ankara, Turkey.
    The increase of endocannabinoid tonus by inhibiting fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL) represents a promising therapeutic approach in a variety of disease to overcome serious central side effects of exocannabinoids. Recent studies reported that systemic administration of FAAH and MAGL inhibitors produce antipruritic action. Dual FAAH/MAGL inhibitors have also been described to get enhanced endocannabinoid therapeutic effect. Read More

    Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial.
    JAMA 2016 Apr;315(16):1715-25
    Chest Disease Department, University Hospital of Strasbourg, Strasbourg University, France.
    Importance: The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a potential novel treatment option for HDM allergy-related asthma.

    Objectives: To evaluate the efficacy and adverse events of the HDM SLIT tablet vs placebo for asthma exacerbations during an inhaled corticosteroid (ICS) reduction period.

    Design, Settings, And Participants: Double-blind, randomized, placebo-controlled trial conducted between August 2011 and April 2013 in 109 European trial sites. Read More

    Crisaborole Topical Ointment, 2%: A Nonsteroidal, Topical, Anti-Inflammatory Phosphodiesterase 4 Inhibitor in Clinical Development for the Treatment of Atopic Dermatitis.
    J Drugs Dermatol 2016 Apr;15(4):390-6
    Crisaborole topical ointment, 2% (formerly known as AN2728) is a benzoxaborole, nonsteroidal, topical, anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor investigational compound that recently completed phase 3 studies for the treatment of mild to moderate atopic dermatitis (AD). The unique configuration of boron within the crisaborole molecule enables selective targeting and inhibition of PDE4, an enzyme that converts the intracellular second messenger 3'5'-cyclic adenosine monophosphate (cAMP) into the active metabolite adenosine monophosphate (AMP). By inhibiting PDE4 and thus increasing levels of cAMP, crisaborole controls inflammation. Read More

    Therapies to improve the cosmetic symptoms of atopic dermatitis.
    Cutis 2016 Mar;97(3):183-6
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease. The cosmetic symptoms of AD can have a serious impact on a patient's quality of life. Although there currently is no cure for AD, treatment is aimed at relieving its symptoms and preventing acute exacerbations as well as improving cosmetic appearance to enhance quality of life. Read More

    ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients.
    J Eur Acad Dermatol Venereol 2016 May 23;30(5):729-47. Epub 2016 Mar 23.
    Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.
    Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease of children and adults. The diagnosis is made using evaluated clinical criteria. Disease activity is best measured with a composite score assessing both objective signs and subjective symptoms, such as SCORAD. Read More

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