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    694 results match your criteria Pruritus and Systemic Disease

    1 OF 14

    Pembrolizumab for the Treatment of Advanced Salivary Gland Carcinoma: Findings of the Phase 1b KEYNOTE-028 Study.
    Am J Clin Oncol 2018 Feb 21. Epub 2018 Feb 21.
    Seoul National University Hospital, Seoul, Republic of Korea.
    Objectives: Treatment options for patients with unresectable or metastatic salivary gland carcinoma (SGC) are limited. Safety and efficacy of pembrolizumab for SGC expressing programmed death ligand 1 (PD-L1) were explored.

    Materials And Methods: A cohort of patients with advanced, PD-L1-positive SGC was enrolled in the nonrandomized, multicohort, phase Ib trial of pembrolizumab in patients with PD-L1-positive advanced solid tumors (KEYNOTE-028; NCT02054806). Read More

    Vitamin D shows in vivo efficacy in a placebo-controlled, double-blinded, randomised clinical trial on canine atopic dermatitis.
    Vet Rec 2018 Feb 1. Epub 2018 Feb 1.
    Clinic of Small Animal Medicine, Ludwig Maximilian University, Munich, Germany.
    Atopic dermatitis (AD) in dogs is among the most common skin diseases in small animal practice. It is an inflammatory disease based on a genetic predisposition to develop hypersensitivity against environmental and food allergens and typical clinical signs up exposure. Treatment sometimes can be difficult and associated with adverse effects. Read More

    Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials.
    Lancet Oncol 2018 Jan 19. Epub 2018 Jan 19.
    National Cancer Institute, Cancer Therapy Evaluation Program, Investigational Drug Branch, Bethesda, MD, USA.
    Background: Patients with metastatic sarcoma have limited treatment options. Nivolumab and ipilimumab are monoclonal antibodies targeting PD-1 and CTLA-4, respectively. We investigated the activity and safety of nivolumab alone or in combination with ipilimumab in patients with locally advanced, unresectable, or metastatic sarcoma. Read More

    Lichen planus pemphigoides treated with ustekinumab.
    Cutis 2017 Dec;100(6):415-418
    Advanced Desert Dermatology/Midwestern University, Glendale, Arizona, USA.
    A 71-year-old woman presented with pink to violaceous, flat-topped, polygonal papules on the volar wrists, extensor elbows, and bilateral lower legs of 3 years' duration. She also had erythematous, violaceous, infiltrated plaques with microvesiculation on the bilateral thighs of several months' duration. She reported pruritus, burning, and discomfort. Read More

    Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects.
    J Clin Aesthet Dermatol 2017 Oct 1;10(10):44-47. Epub 2017 Oct 1.
    Dr. Cohen is from the Department of Dermatology at the University of California San Diego, La Jolla, California.
    Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site.leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease.To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containingand vinpocetine. Read More

    [Lichen ruber planus : Better understanding, better treatment!]
    Hautarzt 2018 Feb;69(2):100-108
    Klinik für Dermatologie, Venerologie und Allergologie, Campus Homburg, Gebäude 6.7, Universität des Saarlandes, Homburg, Deutschland.
    Lichen ruber, also called lichen ruber planus or lichen planus (LP), is a noncontagious inflammatory skin disease. LP is the main representative and namesake of the group of lichenoid diseases, which are characterized by small papules often accompanied by severe itching. With 65% of cases, LP is primarily a disease of the mucous membranes. Read More

    Phosphodiesterase 4 (PDE4) Inhibitors.
    J Am Acad Dermatol 2017 Dec 14. Epub 2017 Dec 14.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois USA. Electronic address:
    Historically, drugs available for treating atopic dermatitis (AD) have been limited to topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI), with systemic immunosuppressants and phototherapy reserved for severe AD. Despite their efficacy, with long term use, these agents have associated safety concerns and limitations. More targeted options with fewer systemic and cutaneous side effects are needed for treating atopic dermatitis. Read More

    Emerging Treatment Options in Atopic Dermatitis: Topical Therapies.
    Dermatology 2017 Dec 8. Epub 2017 Dec 8.
    Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.
    Atopic dermatitis is a chronic inflammatory skin disorder affecting children and adults, with the majority presenting mild to moderate disease severity. The use of topical corticosteroids (TCSs) in combination with emollients has been the mainstay for treating mild to moderate atopic dermatitis since the 1950s, and as a supplement to systemic treatment in severe disease. However, while very effective, TCSs are often accompanied by poor adherence due to corticophobia (fear of using corticosteroids in patients or doctors), unwanted side effects, and in some cases insufficient clinical response. Read More

    Magnitude of benefit for topical crisaborole in the treatment of atopic dermatitis in children and adults does not look promising: a critical appraisal.
    Br J Dermatol 2017 Dec 3. Epub 2017 Dec 3.
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, U.K.
    Aim: To assess the efficacy and safety of crisaborole ointment, a phosphodiesterase 4 inhibitor, for the treatment of mild or moderate atopic dermatitis (AD) in two phase III studies (AD-301 and AD-302).

    Design And Setting: Two identically designed multicentre, double-blind randomized controlled trials were conducted in the U.S. Read More

    Systemic granulomatous disease in dairy cattle during a dicyandiamide feeding trial.
    N Z Vet J 2018 Mar 20;66(2):108-113. Epub 2017 Dec 20.
    c Institute of Veterinary, Animal and Biomedical Sciences , Massey University , Private Bag 11-222, Palmerston North , 4442 , New Zealand.
    Case History: Mature, in-calf, non-lactating, Friesian or Friesian-cross cows were fed dicyandiamide (DCD) at daily doses of 0.15 g/kg (Group 1; n=31), 0.45 g/kg (Group 2; n=21) and 0. Read More

    Dupilumab with concomitant topical corticosteroids in adult patients with atopic dermatitis who are not adequately controlled with or are intolerant to ciclosporin A, or when this treatment is medically inadvisable: a placebo-controlled, randomized phase 3 clinical trial (LIBERTY AD CAFÉ).
    Br J Dermatol 2017 Nov 28. Epub 2017 Nov 28.
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY, U.S.A.
    Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that may require systemic therapy. Ciclosporin A (CsA) is a widely-used, potent immunosuppressant for AD. CsA is not effective in all patients, and side effects limit its use. Read More

    The triad of pruritus, xanthomas, and cholestasis: Two cases and a brief review of the literature.
    Pediatr Dermatol 2017 Nov;34(6):e305-e308
    University of Mississippi Medical Center, Jackson, MS, USA.
    When encountered in children, xanthomas are most commonly associated with a group of disorders known as familial hyperlipidemias. Aside from cosmetic concerns, these xanthomas are typically asymptomatic, but when generalized pruritus is a prominent associated symptom, clinicians should consider a different set of diagnoses that includes cholestasis of the liver. In this article we present two illustrative cases of children with cholestatic disease, pruritus, and xanthomas and discuss other disorders that may include this triad. Read More

    MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.
    Neuroreport 2017 Dec;28(17):1127-1133
    aDepartment of Physiology, School of Medicine and Life Sciences bKey Laboratory of Prevention and Treatment of Chinese Medicine in Neurological Disease, Nanjing University of Chinese Medicine cDepartment of Biochemistry, College of Life Sciences, Nanjing Normal University, Nanjing dDepartment of Physiology, College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning, China.
    Chronic itch, a distressing symptom of many cutaneous and systemic diseases, significantly impairs quality of life. However, its underlying molecular mechanism is still unclear. Mas-related G protein-coupled receptor A3 (MrgprA3) is considered an itch-specific receptor. Read More

    Atopic Dermatitis: Managing the Itch.
    Adv Exp Med Biol 2017 ;1027:161-177
    Department of Dermatology, George Washington University, Washington, DC, USA.
    Atopic dermatitis has a substantial impact on sleep, appearance, psychological well-being, and other qualities of life. The visual appearance of lichenification, cheilitis, hyperpigmentation, ichthyosis, and erythema can be socially stigmatizing, and treatment of these symptoms is challenging. In managing pruritus in patients, practitioners should assess and document pruritus through questionnaires at each routine visit. Read More

    Aprepitant for the Treatment of Chronic Refractory Pruritus.
    Biomed Res Int 2017 19;2017:4790810. Epub 2017 Sep 19.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Chronic pruritus is a difficult condition to treat and is associated with several comorbidities, including insomnia, depression, and decreased quality of life. Treatment for chronic itch includes corticosteroids, antihistamines, and systemic therapies such as naltrexone, gabapentin, UV light therapy, and immunomodulatory treatments, including azathioprine, methotrexate, and cellcept. However, some patients still remain refractory to conventional therapy. Read More

    Use of oral antidepressants in patients with chronic pruritus: A systematic review.
    J Am Acad Dermatol 2017 Dec 21;77(6):1068-1073.e7. Epub 2017 Oct 21.
    Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
    Background: Chronic pruritus is a common skin symptom with marked impact on quality of life. Adequate treatment can be challenging for clinicians, demanding the exploration of new treatment options such as oral antidepressants.

    Objective: To evaluate the use of oral antidepressants in chronic pruritus by a systematic overview of the available relevant literature. Read More

    The relationship between pruritus and clinical variables in patients with psoriasis.
    An Bras Dermatol 2017 Jul-Aug;92(4):470-473
    Department of Biostatistics, Medical Faculty, Bezmialem Vakif University - Istanbul, Turquia.
    Background:: Pruritus is the most commonly occurring subjective symptom of dermatological disease. Published data on both prevalence and intensity of pruritus in psoriasis is limited.

    Objective:: In this study we aimed to investigate the prevalence of pruritus and its relation with psoriasis area severity index, body mass index and presence of systemic disease in patients with psoriasis. Read More

    Therapeutic pipeline for atopic dermatitis: End of the drought?
    J Allergy Clin Immunol 2017 Sep;140(3):633-643
    Department of Dermatology and Allergy, University of Bonn, and the Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
    Until the past year, our therapeutic armamentarium for treating atopic dermatitis (AD) was still primarily topical corticosteroids and, for more severe disease, systemic immunosuppressants. The pipeline of more targeted topical and systemic therapies is expanding based on our growing understanding of the mechanism for AD and is particularly focused on suppressing the skewed immune activation. Most agents are in phase 2 clinical trials. Read More

    Skin as a marker of general feline health: Cutaneous manifestations of systemic disease.
    J Feline Med Surg 2017 Sep;19(9):948-960
    Small Animal Specialist Hospital, Sydney, NSW, Australia, and Associate Lecturer, University of Sydney, NSW, Australia.
    Practical relevance: Although most skin lesions occur due to diseases primarily affecting the skin, some reflect important systemic diseases. Such lesions may relate directly to the systemic disease, or may occur due to secondary skin diseases that develop because of immunosuppression. Early recognition of skin changes as a marker of systemic disease will maximise patient outcomes. Read More

    Therapeutic comparison between treatments for Vulvar Lichen Sclerosus: study protocol of a randomized prospective and controlled trial.
    BMC Womens Health 2017 Aug 10;17(1):61. Epub 2017 Aug 10.
    Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University/UNINOVE, 249 Vergueiro Street, Liberdade, São Paulo, SP, 01504-001, Brazil.
    Background: Vulvar lichen sclerosus (VLS) is a lymphocyte-mediated disease of unknown etiology that can cause intense itching as well stenosis, hindering the evacuation and urination. It can also limit the sex life due to severe local pruritus, pain and dyspareunia (pain during sexual intercourse). The standard treatment for this disease is the use of topical corticosteroids to reduce the clinical symptoms and to try to increase disease-free intervals. Read More

    Mastocytosis: from a Molecular Point of View.
    Clin Rev Allergy Immunol 2017 Jul 19. Epub 2017 Jul 19.
    Floridsdorf Allergy Center (FAZ), Vienna, Austria.
    Mast cells (MCs) are physiologically activated by binding of stem cell factor (SCF) to the extracellular domains of the Kit receptor. This binding increases the proliferation and prolongs the survival of normal mature MCs, as well as intensifies the release of mediators. In mastocytosis, somatic mutations of the coding Kit gene cause autocrine dysregulation and lead to constitutive KIT activation even in the absence of its ligand SCF. Read More

    Treatment of Uremic Pruritus: A Systematic Review.
    Am J Kidney Dis 2017 Nov 15;70(5):638-655. Epub 2017 Jul 15.
    Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Section of Nephrology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Chronic Disease Innovation Centre, Seven Oaks Hospital, Winnipeg, Manitoba, Canada; Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:
    Background: Uremic pruritus is a common and burdensome symptom afflicting patients with advanced chronic kidney disease (CKD) and has been declared a priority for CKD research by patients. The optimal treatments for uremic pruritus are not well defined.

    Study Design: Systematic review. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Blood lead level is a positive predictor of uremic pruritus in patients undergoing hemodialysis.
    Ther Clin Risk Manag 2017 12;13:717-723. Epub 2017 Jun 12.
    Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital, Linkou Medical Center.
    Although uremic pruritus (UP) is a common and annoying symptom for end-stage renal disease patients on hemodialysis (HD) and peritoneal dialysis, its pathogenesis is poorly understood. However, systemic inflammation is one of the possible pathogenesis of UP, and blood lead level (BLL) has been noted to be associated with inflammation and nutritional status in long-term HD patients. There might be an interaction or association, therefore, between BLL and UP through systemic inflammation. Read More

    Management of poorly controlled indolent systemic mastocytosis using narrowband UVB phototherapy.
    Cutis 2017 May;99(5):E30-E33
    Georgetown University Hospital/Washington Hospital Center, Washington, DC, USA.
    The mastocytoses comprise a group of proliferative stem cell disorders defined by the abnormal accumulation of mast cells (MCs) in the skin or other body tissues including the bone marrow, gastrointestinal tract, and liver. Systemic mastocytosis is defined by the presence of one major and one minor criterion or 3 minor criteria delineated by the World Health Organization (WHO). We present the case of a 57-year-old woman with a 10-year history of red-brown pruritic maculopapular lesions on the upper and lower extremities and trunk who was originally diagnosed with cutaneous mastocytosis. Read More

    Porokeratosis ptychotropica responding to photodynamic therapy: An alternative treatment for a refractory disease.
    Photodermatol Photoimmunol Photomed 2017 Sep 20;33(5):271-274. Epub 2017 Jun 20.
    Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
    Background: Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis with a special predisposition to affect body folds, particularly the intergluteal cleft. This disease is resistant to most topical and systemic treatments, as shown in the review of the literature we provide here. Itching and discomfort are often a difficult problem to solve. Read More

    The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study.
    Vet Dermatol 2017 Oct 17;28(5):485-e113. Epub 2017 May 17.
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 311 Diagnostic Medical Center, 300 West Drake, Fort Collins, CO, 80524, USA.
    Background: Oclacitinib is a selective Janus kinase inhibitor for the treatment of canine allergic pruritus and atopic dermatitis in dogs. Glucocorticoids and ciclosporin increase urinary tract infection (UTI) frequency in dogs with inflammatory skin disease.

    Objective: Prospective study to evaluate the frequency of UTI and subclinical bacteriuria in dogs with allergic dermatitis receiving oclacitinib. Read More

    Chronic Pruritus: Current and Emerging Treatment Options.
    Drugs 2017 Jun;77(9):999-1007
    Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Von-Esmarch-Str. 58, Münster, 48149, Germany.
    Chronic pruritus remains a central societal issue because of its high occurrence and the substantial decrease in quality of life it may cause to affected individuals. Not only dermatological conditions, but also systemic, neurological, or psychiatric diseases may lead to chronic pruritus. Additionally, various underlying conditions may coexist or the cause may be unknown. Read More

    [Pruritus of the scalp : Simply pulling out your hair?]
    Hautarzt 2017 Jun;68(6):449-456
    Abteilung Klinische Sozialmedizin, Schwerpunkt: Berufs- und Umweltdermatologie, Universitätsklinikum, Ruprecht-Karls-Universität Heidelberg, Voßstr. 2, 69115, Heidelberg, Deutschland.
    Scalp pruritus is a frequent symptom and can be caused by dermatologic diseases, contact allergies, neurologic, psychiatric/somatoform and systemic diseases. In daily clinical practice scalp pruritus is a diagnostic and therapeutic challenge, especially if no detectable lesions are present. A detailed patient history and the inspection of scalp and the skin of the whole body are essential for diagnosis. Read More

    Association of Dermatoses with Duration and Quantum of Alcohol Intake: A Comparative Cross-sectional Study.
    Indian J Dermatol 2017 Mar-Apr;62(2):184-190
    Department of Dermatology, Dr. D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India.
    Background: Chronic alcohol intake impacts skin directly, through organ dysfunction or by modifying preexisting dermatoses. However, dermatoses afflicting chronic alcoholics figure in a few studies only.

    Aim: This study aims to correlate the spectrum of dermatoses in chronic alcoholics with the quantum/duration of alcohol intake and raised liver transaminases. Read More

    The efficacy and safety of intravenous lidocaine for analgesia in the older adult: a literature review.
    Br J Pain 2017 Feb 24;11(1):23-31. Epub 2016 Oct 24.
    North Devon District Hospital, Barnstaple, UK.
    Opioids remain the mainstay of analgesia for the treatment of moderate to severe acute pain. Even in the young, the use of opioids can be associated with an increased incidence of post-operative complications such as respiratory depression, vomiting, pruritus, excessive sedation, slowing of gastrointestinal function, and urinary retention. The need to manage acute pain in the older patient is becoming more common as the population ages, and increasingly older patients are undergoing more major surgery. Read More

    [Pathophysiology of atopic blepharokeratoconjunctivitis].
    Ophthalmologe 2017 Jun;114(6):504-513
    Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
    Atopic dermatitis (AD) is a systemic inflammatory disease, which is characterized by pronounced eczema and pruritus. In addition to the involvement of the entire integument, the periocular lid skin and the surface of the eye are frequently involved. Ocular involvement may occur solely without dermatitis of facial or body skin. Read More

    Sublingual immunotherapy tablets as a disease-modifying add-on treatment option to pharmacotherapy for allergic rhinitis and asthma.
    Postgrad Med 2017 Aug 27;129(6):581-589. Epub 2017 Mar 27.
    e Merck & Co., Inc. , Kenilworth , NJ , USA.
    Allergic rhinitis (AR) with or without conjunctivitis (AR/C) is associated with a significant health and economic burden, and is often accompanied by asthma. Pharmacotherapies are the mainstay treatment options for AR and asthma, but guidelines also recommend allergy immunotherapy (AIT). Unlike pharmacotherapies, AIT has the ability to modify the underlying immunologic mechanisms of AR and asthma with the potential for long-term benefits after treatment is discontinued. Read More

    Therapeutic Effects of Korean Red Ginseng Extract in a Murine Model of Atopic Dermatitis: Anti-pruritic and Anti-inflammatory Mechanism.
    J Korean Med Sci 2017 Apr;32(4):679-687
    Department of Dermatology, The Catholic University of Korea College of Medicine, Incheon St. Mary's Hospital, Incheon, Korea.
    Korean red ginseng (KRG) and ginsenosides exhibit diverse biological effects, including anti-inflammatory and anti-allergic. We aimed to investigate the therapeutic effect of KRG in a murine model of atopic dermatitis (AD) is mediated whether by diminishing the pruritus or by suppressing the inflammation. Thirty NC/Nga mice were randomly divided to 5 groups. Read More

    Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway.
    J Immunol 2017 04 22;198(7):2543-2555. Epub 2017 Feb 22.
    Section of Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06510; and
    Increased expression of Th22 cytokine IL-22 is a characteristic finding in atopic dermatitis (AD). However, the specific role of IL-22 in the pathogenesis of AD in vivo has yet to be elucidated. Consistent with observations in human AD, IL-22 was significantly increased in the AD skin of mice after epicutaneous sensitization to house dust mite allergen. Read More

    Clinical Signs, Staphylococcus and Atopic Eczema-Related Seromarkers.
    Molecules 2017 Feb 14;22(2). Epub 2017 Feb 14.
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.
    Childhood eczema or atopic dermatitis (AD) is a distressing disease associated with pruritus, sleep disturbance, impaired quality of life andisolation. The pathophysiology of AD is complex and various seromarkers of immunity are involved. We investigated if anti-staphylococcal enterotoxin IgE (anti-SE), selected seromarkers of T regulatory (Treg), T helper (Th) and antigen-presenting cells (APC) are associated with clinical signs of disease severity and quality of life. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    A phase I clinical trial demonstrates that nfP2X-targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma.
    Br J Dermatol 2017 Jul 11;177(1):117-124. Epub 2017 Jun 11.
    Biosceptre (Australia) Pty Ltd., 11 Julius Avenue, North Ryde, NSW, 2113, Australia.
    Background: Expression of P2X, an ATP-gated calcium channel, increases cancer cell proliferation and invasiveness. A variant of P2X(termed nfP2X), in which a normally hidden epitope (E200) is exposed for antibody binding, is observed in a variety of different cancers.

    Objectives: To investigate the safety, tolerability and pharmacokinetics and assess indicative efficacy of a novel antibody ointment as a therapeutic for basal cell carcinoma (BCC). Read More

    Clinical Features, Response to Treatment, and Outcomes of IgG4-Related Sclerosing Cholangitis.
    Clin Gastroenterol Hepatol 2017 Jun 20;15(6):920-926.e3. Epub 2017 Jan 20.
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
    Background & Aims: Immunoglobulin G4 sclerosing cholangitis (IgG4-SC) is a biliary tract manifestation of IgG4-related systemic disease. We investigated the demographics, clinical features at presentation, treatment response, and outcomes of IgG4-SC using data from a large-scale survey in Japan.

    Methods: We performed a retrospective cohort study of 527 patients with IgG4-SC (436 female; median age, 66. Read More

    Clinical features of shiitake dermatitis: a systematic review.
    Int J Dermatol 2017 Jun 4;56(6):610-616. Epub 2017 Jan 4.
    Department of Dermatology, Mayo Clinic Florida, Jacksonville, FL, USA.
    Shiitake dermatitis is a rare cutaneous reaction to lentinan, a polysaccharide component in the cell walls of shiitake mushrooms (Lentinula edodes). Herein, we systematically review the case report and case series English-language literature on shiitake dermatitis, which refers to a total of 50 patients (38 males, 12 females; mean age: 44.58 years). Read More

    [Preclinical safety evaluation of chloral hydrate after topical application using the example of psoriatic itch].
    Hautarzt 2017 Mar;68(3):217-223
    Klinik für Dermatologie und Allergologie, Charité Universitätsmedizin Berlin, Berlin, Deutschland.
    Background: Psoriasis is known today as a T‑cell-mediated autoimmunological systemic disease. The chronic inflammatory processes involve neuroimmunological factors that are held responsible not only for various aspects of psychiatric-neurological comorbidities but also for neurosensory problems, primarily itching. Amongst other things, the significance of GABAreceptors are often discussed in this context. Read More

    Systemic Mastocytosis Causing Refractory Pruritus in a Liver Disease Patient.
    ACG Case Rep J 2016 Aug 23;3(4):e152. Epub 2016 Nov 23.
    Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR.
    Systemic mastocytosis (SM) results from clonal, neoplastic proliferation of abnormal mast cells. Patients become susceptible to itching, urticaria, and anaphylactic shock, which occurs due to histamine release from mast cells. SM may coexist alongside other systemic diseases, thus confounding the overall clinical presentation. Read More

    [Cutaneous manifestations in renal diseases].
    Hautarzt 2016 Dec;67(12):960-969
    Dermatologische Abteilung, Donauspital, Langobardenstr. 122, 1220, Wien, Österreich.
    In addition to general skin changes like pallor or dryness and the frequent, often excruciating nephrogenic pruritus, specific diseases in patients with renal failure may occur. Acquired perforating dermatoses are usually also highly pruritic. Calciphylaxis is a severe disease with poor prognosis. Read More

    [Diffuse cutaneous mastocytosis of an infant: A case report].
    Arch Pediatr 2016 Nov 23;23(11):1150-1152. Epub 2016 Sep 23.
    Service de dermatologie, centre hospitalier universitaire Ibn Sina, rue Famfdal Cherkaoui, BP 6527, 10000 Rabat, Maroc.
    Mastocytosis is a group of diseases related to abnormal accumulation and proliferation of mast cells in one or more organs. They may be associated with an acquired point mutation and the activation of the receptor tyrosine-kinase c-KIT of CFS (mast cell growth factor). The clinical manifestations are varied and secondary to the release of mast cell mediators and/or infiltration of various organs. Read More

    Small animal disease surveillance: pruritus, and coagulase-positive staphylococci.
    Vet Rec 2016 Oct;179(14):352-355
    BSAVA, Woodrow House, 1 Telford Way, Waterwells Business Park, Quedgeley, Gloucestershire GL2 2AB, UK.
    Presentation for pruritus comprised 6.5 per cent, 3.6 per cent and 2. Read More

    African American race associated with body image dissatisfaction among patients with systemic sclerosis.
    Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):70-73. Epub 2016 May 10.
    Georgetown University Medical Center, Washington, DC, USA.
    Objectives: Studies have shown a high degree of body image dissatisfaction among patients with systemic sclerosis (SSc). We aimed to identify demographic and phenotypic characteristics that correlate with body image dissatisfaction.

    Methods: Ninety-eight patients with SSc were recruited from Georgetown University Medical Center 2003-2004. Read More

    Pemphigus herpetiformis - a case report of a rare form of pemphigus and review of the literature.
    Vojnosanit Pregl 2016 Oct;73(10):967-72
    Introduction: Pemphigus herpetiformis is the rare variant of pemphigus with characteristic clinical features, histopathological findings different from the convectional pemphigus, and immunological findings consistent with pemphigus.

    Case Report: We presented a 65-year-old woman with initial pruritus followed by pruritic urticarial papules and plaques, some with annular rings of tense vesicles on the periphery, on the trunk and extremities, with no mucous lesions. Histopathological examination demonstrated spongiosis and intraepidermal vesicles in the mid or subcorneal epidermis in some biopsy specimen, with neutrophil and eosinophil infiltrate. Read More

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