21,883 results match your criteria Pruritus and Systemic Disease


Tezepelumab, an anti-TSLP monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

MedImmune, Cambridge, UK.

Background: Tezepelumab (AMG 157/MEDI9929), a first-in-class monoclonal antibody, targets thymic stromal lymphopoietin, a cytokine implicated in atopic dermatitis (AD) pathogenesis.

Objective: Evaluate efficacy and safety of tezepelumab in adults with moderate to severe AD.

Methods: In this phase 2a study (NCT02525094), 113 patients were randomized 1:1 to subcutaneous tezepelumab 280 mg or placebo every 2 weeks, plus Class 3 topical corticosteroids (TCS). Read More

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December 2018

Relief of intractable pruritus with romidepsin in patients with cutaneous T-cell lymphoma: a series of 4 cases.

Dermatol Ther 2018 Dec 14:e12804. Epub 2018 Dec 14.

Cutaneous Lymphoma Program, Toni Stephenson Lymphoma Center, City of Hope, Duarte, CA.

Cutaneous T-cell lymphomas (CTCL) are a relatively rare and heterogeneous group of non-Hodgkin lymphomas that typically present in the skin. The majority of patients with CTCL experience pruritus, which can interfere with daily activities, significantly impact quality of life, and is typically uncontrolled by standard anti-itch therapies. Several lymphoma treatments have reported anti-pruritic effects including romidepsin, a potent class 1 selective histone deacetylase inhibitor approved for the treatment of patients with CTCL who have had at least 1 prior systemic therapy. Read More

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December 2018
2 Reads

Diphenhydramine and QT prolongation - A rare cardiac side effect of a drug used in common practice.

J Cardiol Cases 2015 Oct 3;12(4):126-129. Epub 2015 Jul 3.

Advocate Christ Medical Center, Covington Ct, Oak Brook, IL, USA.

There have been few cases in recent times where QT interval prolongation has been studied with regards to the use of diphenhydramine. We present a case of a patient who presented because of shortness of breath and needed emergent hemodialysis; during the course of which he developed prolonged QT interval on electrocardiography, which was correlated interestingly with the use of diphenhydramine. Pruritus is a common symptom experienced by dialysis patients. Read More

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October 2015

Do All Patients With Polycythemia Vera or Essential Thrombocythemia Need Cytoreduction?

J Natl Compr Canc Netw 2018 Dec;16(12):1539-1545

Department of Medicine, and Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine; and Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois.

Polycythemia vera (PV) and essential thrombocythemia (ET) are Philadelphia chromosome-negative chronic myeloproliferative neoplasms (MPNs), characterized by expansion of normal blood counts, bleeding, thrombosis, and the potential for transformation to myelofibrosis (MF) or acute myeloid leukemia (AML). The primary goals of treatment for MPNs are to reduce the risk of thrombosis, alleviate systemic symptom burden (eg, fatigue, pruritus, microvascular symptoms, and symptomatic splenomegaly), and to prevent transformation to MF/AML. Preventing transformation is clearly important, but not expected with current therapies. Read More

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December 2018

Evolution of symptoms and quality of life during Zika virus infection: A 1-year prospective cohort study.

J Clin Virol 2018 Dec 26;109:57-62. Epub 2018 Sep 26.

French Armed Forces Health Service in French Guiana, Cayenne, French Guiana; Unité de Parasitologie et Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France; Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), IHU - Méditerranée Infection, Marseille, France.

Background: Although the complications of Zika virus infection have been well described, the clinical pattern has not been reported in enough detail to differentiate this infection from those with other arboviroses, and no longitudinal study has yet been published on the persistence of symptoms and quality of life.

Objectives: were to describe bio-clinical pattern and quality of life during ZIKV infection, and their evolution.

Study Design: We present a 1-year clinical follow-up of 49 people infected with Zika virus in French Guiana, for whom the diagnosis was confirmed by RT-PCR in serum or urine. Read More

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December 2018

Measurement of Nocturnal Scratching in Patients with Pruritus Using a Smartwatch: Initial Clinical Studies with the Itch Tracker App.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Future Design, Maruho Co Ltd, 531-0071 Osaka, Japan.

Three clinical studies were conducted to test a newly-developed app for smartwatches, which included an algorithm to measure nocturnal scratching using acceleration data. The first study in 5 patients with atopic dermatitis demonstrated high reliability of the app for measurement of scratching compared with video monitoring (positive predictive value 90.2 ± 6. Read More

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December 2018

Effect of an insect protein-based diet on clinical signs of dogs with cutaneous adverse food reactions.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):297-302. Epub 2018 Dec 12.

Objective: Edible insects (like mealworms, locusts and crickets) contain energy, protein, fatty acids, minerals and trace elements and have been found to be high quality food sources. They could provide a new food source for patients with adverse food reactions, as well as being of ecological and ethical interest. The aim of this study was to evaluate the effect of a new commercially available, insect protein-based diet on the clinical signs in those dogs via Canine Atopic Dermatitis Lesion Index (CADLI), Pruritus Visual Analogue Scale (PVAS) and coat quality score. Read More

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October 2018
4 Reads

Clinical Characterization of Immunotherapy-Related Pruritus Among Patients Seen in 2 Oncodermatology Clinics.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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December 2018

Skin Reactions to Immune Checkpoint Inhibitors.

Adv Exp Med Biol 2018 ;995:117-129

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The novelty of immune checkpoint inhibitors has only recently led to the characterization of cutaneous adverse events (AEs). This, along with the substantial rate of cutaneous reactions, has left many clinicians without sufficient familiarity to diagnose and treat. Pruritus and rash are among the top five immune-related AEs reported in clinical trials for this class of therapy. Read More

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January 2018
2 Reads

Efficacy of hydrophilic or lipophilic emulsions containing extract in treatment of different types of pruritus.

Clin Cosmet Investig Dermatol 2018 20;11:591-602. Epub 2018 Nov 20.

Dr. August Wolff GmbH & Co. KG Arzneimittel, Bielefeld, Germany,

Background: Pruritus reduces quality of life and may occur at different sites of the body. To alleviate pruritus, lipid replenishing and rehydration of the skin is often unsatisfactory. Thus, products with additional antipruritic effects are needed. Read More

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November 2018
1 Read

Establishment of infestivity model for var in Nigerian dogs.

J Parasit Dis 2018 Dec 22;42(4):519-526. Epub 2018 Aug 22.

2Department of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria.

Experimental transmission patterns involved with the establishment of mange in dogs were studied to ascertain the effective means of infestation model for mange experiments in dogs. A total of eighteen (18) dogs were used out of which three (3) were naturally infested with var Five (5) healthy dogs were co-mingled with the three (3) donor dogs for direct contact transmission. Another five (5) mange free dogs were aggregated in a kennel recently vacated by mange infested dogs for environmental and formite transmission while the last five (5) healthy dogs had scrapings from a proximate area of mange lesion sites transferred into the pinnae of each dog for experimental and indirect contact transmission. Read More

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December 2018

Anaphylactic shock associated with intravenous amiodarone.

J Cardiol Cases 2014 Feb 12;9(2):61-62. Epub 2013 Dec 12.

Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey.

A 64-year-old woman was admitted to our emergency department with shortness of breath and palpitation which started 2 h before her admission. She had a history of rheumatic mitral valve disease and was on drug treatment with warfarin and metoprolol. The patient was orthopneic, blood pressure was 108/68 mmHg with an irregular pulse with a heart rate of 158 beats per minute, and respiratory rate was 23 times per minute. Read More

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February 2014
2 Reads

Comparison of demographic data, disease severity and response to treatment, between dogs with atopic dermatitis and atopic-like dermatitis: a retrospective study.

Vet Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Veterinary Clinical Sciences and Surgery, Universidade Federal de Minas Gerais, 6627 Antônio Carlos Ave, Belo Horizonte, 31270-901, Brazil.

Background: Limited information is available describing the features of canine atopic-like dermatitis (ALD) compared with atopic dermatitis (AD).

Objectives: To compare demographic data, disease severity and response to therapy between ALD and AD dogs.

Animals: Two hundred and fifty-three atopic dogs with intradermal and serum allergen-specific IgE test results were selected retrospectively. Read More

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December 2018
2 Reads

[Discrasia linfoide epiteliotrópica de células T. Tratamiento con radiación ultravioleta].

Gac Med Mex 2018 ;154(Supp 2):S41-S49

Unidad de Fototerapia. Hospital General Dr. Manuel Gea González, Ciudad de México, México.

Introduction: T-cell lymphoid dyscrasia is a group of different, infrequent, epitheliotropic inflammatory dermatosis that precede cutaneous T-cell lymphomas. Treatment with ultraviolet radiation is safe and efficacious.

Objective: To describe responses to treatment, secondary effects and complications. Read More

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January 2018

[New possibilities for the newborn's protection against vertical HBV trasmission - a case report].

Pol Merkur Lekarski 2018 Nov;45(269):192-194

Tadeusz Browicz Hospital of Infectious Diseases, Bydgoszcz, Poland.

The patient was diagnosed with chronic hepatitis B at 19 years old. Biochemical, serological and histopathological diagnostic processes were followed by pegylated interferon treatment. After 24 weeks of therapy treatment was discontinued due to pathological thyroid hormones values. Read More

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November 2018

Weeding Out the Problem: The Impact of Preoperative Cannabinoid Use on Pain in the Perioperative Period.

Anesth Analg 2018 Dec 7. Epub 2018 Dec 7.

From the Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada.

Background: The recreational and medical use of cannabinoids has been increasing. While most studies and reviews have focused on the role of cannabinoids in the management of acute pain, no study has examined the postoperative outcomes of surgical candidates who are on cannabinoids preoperatively. This retrospective cohort study examined the impact of preoperative cannabinoid use on postoperative pain scores and pain-related outcomes in patients undergoing major orthopedic surgery. Read More

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December 2018
1 Read

Current treatment strategies in refractory chronic pruritus.

Curr Opin Pharmacol 2018 Dec 6;46:1-6. Epub 2018 Dec 6.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Chronic pruritus is a highly prevalent, debilitating disease, which is often refractory to conventional therapies. A step-wise, guideline-driven approach should be adopted in the management of these patients. Emollients as well as topical corticosteroids if appropriate should be initiated whilst looking for the cause underlying the pruritus. Read More

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December 2018

Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors.

Eur J Cancer 2018 Dec 6;107:8-14. Epub 2018 Dec 6.

Department of Dermatology, University Hospital of Zürich, CH-8091, Zürich, Switzerland; Institute of Immunobiology, Kantonsspital St.Gallen, CH-9007, St. Gallen, Switzerland; Department of Oncology and Hematology, Kantonsspital St. Gallen, CH-9007, St. Gallen, Switzerland; Department of Dermatology, Kantonsspital St. Gallen, CH-9007, St. Gallen, Switzerland. Electronic address:

Background: Checkpoint inhibitors (CIs) are highly effective but can induce severe immune-related adverse events (irAEs), which cannot be predicted. We investigated whether human leukocyte antigen (HLA) genes predispose to developing of irAEs during therapy and thus hold a predictive role.

Methods: We established a prospective observational single-centre study and collected data from patients with either metastatic non-small cell lung cancer (NSCLC) or metastatic melanoma, who were treated with anti-PD-1 (programmed cell death receptor 1), anti-CTLA4 (cytotoxic T-lymphocyte-associated protein 4) or both CIs combined. Read More

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December 2018
1 Read

Brief Report: Pembrolizumab in Combination With Erlotinib or Gefitinib as First-Line Therapy for Advanced Non-Small-Cell Lung Cancer With Sensitizing EGFR Mutation.

J Thorac Oncol 2018 Dec 4. Epub 2018 Dec 4.

South Texas Accelerated Research Therapeutics, 4383 Medical Dr, San Antonio, TX 78229, USA.

Introduction: Anti-EGFR agents are standard treatments for patients with EGFR-mutant advanced NSCLC. The feasibility of combining erlotinib or gefitinib with anti-PD1 immunotherapy pembrolizumab was evaluated in the phase 1/2 KEYNOTE-021 (NCT02039674) study.

Methods: Adults with previously untreated stage IIIB/IV EGFR-mutant NSCLC were treated with pembrolizumab 2 mg/kg IV every 3 weeks plus oral erlotinib 150 mg daily in cohort E or oral gefitinib 250 mg daily in cohort F, using a 3+3 design with cohort expansion. Read More

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December 2018

Cross-cultural validation of the Itch Man Scale in pediatric burn survivors in a South African setting.

Burns 2018 Dec 5. Epub 2018 Dec 5.

Department of Paediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. Electronic address:

Introduction: Pruritus or itch is a common symptom after burn injuries. The Itch Man Scale has been recommended to assess itch severity in children. The aim of this prospective observational study was to perform a cross-cultural validation of the Itch Man Scale by comparing it with the Numeric Rating Scale (NRS) and the Toronto Pediatric Itch Scale. Read More

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December 2018
1 Read

Valchlor maintenance therapy for patients with mycosis fungoides who received low dose total skin electron beam treatment.

Chin Clin Oncol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma within the general population. Low dose total skin electron beam therapy (TSEBT) and topical nitrogen mustard (Valchlor) are two treatment modalities that have been proven to be efficacious in the treatment of MF. While each have been studied independently in various clinical trials, the use of Valchlor as maintenance therapy after completion of low dose TSEBT is rarely implemented due to the lack of evidence in the literature. Read More

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November 2018

Pembrolizumab in patients with programmed death ligand 1-positive advanced ovarian cancer: Analysis of KEYNOTE-028.

Gynecol Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Objective: To evaluate safety, tolerability, and antitumor activity of pembrolizumab monotherapy in patients with programmed death ligand 1 (PD-L1)-expressing advanced ovarian cancer enrolled in the multicohort, phase Ib KEYNOTE-028 trial.

Methods: Key inclusion criteria were age ≥18 years; advanced ovarian epithelial, fallopian tube, or primary peritoneal carcinoma; failure of previous therapy; and tumor PD-L1 positivity. Patients received pembrolizumab (10 mg/kg every 2 weeks) for ≤24 months or until disease progression/intolerable toxicity. Read More

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December 2018

Use of Systemic Treatment in Patients with Chronic Pruritus: A Survey of Dermatologists in the Netherlands.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Radboud university medical center, 6500HB Nijmegen, The Netherlands.

Treatment of chronic pruritus can be a challenge for clinicians. Several systemic treatments have been suggested to reduce itch, such as gabapentinoids and antidepressants. The aim of this study was to assess the current practice of dermatologists regarding systemic treatment in patients with chronic pruritus, and to identify possible barriers in the prescription of these treatments. Read More

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December 2018
5 Reads

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

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December 2018
4 Reads

Promising efficacy of SHR-1210, a novel anti-programmed cell death 1 antibody, in patients with advanced gastric and gastroesophageal junction cancer in China.

Cancer 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The clinical response to anti-programmed cell death 1 (PD-1) antibodies in patients with advanced gastric and gastroesophageal junction (GEJ) cancer in China has not been reported.

Methods: This study evaluated the efficacy and safety of SHR-1210, an anti-PD-1 antibody, in patients with advanced gastric/GEJ cancer in a phase 1 trial. The associations between candidate biomarkers (programmed death ligand 1 [PD-L1] expression, mismatch repair status, tumor mutation load, and lactate dehydrogenase [LDH] levels) and the efficacy of SHR-1210 were also explored. Read More

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December 2018
1 Read
4.889 Impact Factor

Water-related dermatoses.

Int J Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Water-related dermatoses are a spectrum of diseases that are associated with water exposure. They result either from the direct influence of water or after injury from water inhabitants. In this review, clinical entities that manifest after water exposure (aquagenic pruritus, aquagenic urticaria, and aquagenic wrinkling of the palms) will be discussed with particular focus on the reported pathogenesis. Read More

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December 2018
1 Read

Pityriasis Rosea: Clinical Profile from Central India.

Indian Dermatol Online J 2018 Nov-Dec;9(6):414-417

Department of Dermatology, AIIMS, Raipur, India.

Background: Pityriasis rosea (PR) is a common, self-limiting dermatologic disorder. The information regarding the clinical profile of the disease in India is limited because of inadequate studies.

Materials And Methods: A retrospective, record-based study on the clinical presentation of PR was conducted in a tertiary care center based in Central India. Read More

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December 2018
1 Read

The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis.

Cutan Ocul Toxicol 2018 Dec 2:1-17. Epub 2018 Dec 2.

a Department of Pharmacy , Renmin Hospital of Wuhan University , Wuhan , Hubei , 430060 , P.R. China.

Background: This meta-analysis was conducted to assess the risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients.

Methods: We considered relevant prospective randomized Phase I, II and III trials of melanoma patients on the combined BRAF and MEK inhibition versus BRAF inhibition, describing events of rash, photosensitivity reaction (PR), hyperkeratosis (HK), alopecia, cutaneous squamous-cell carcinom(cSCC), skin papilloma(SP), pruritus and hand-foot syndrome(HFS), as eligible for inclusion.

Results: Eight trials comprising 3163 patients were included in the meta-analysis. Read More

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December 2018

The Therapeutic Potential of Cannabinoids in Dermatology

Skin Therapy Lett 2018 11;23(6):1-5

Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC, USA

Cannabinoids have demonstrated utility in the management of cancer, obesity, and neurologic disease. More recently, their immunosuppressive and anti-inflammatory properties have been identified for the treatment of several dermatologic conditions. This review thus assesses the therapeutic potential of phytocannabinoids, endoocannabinoids, and chemically synthetic cannabinoids in the management of cutaneous disease. Read More

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November 2018
3 Reads

Safety of a formulation containing chitosan microparticles with chamomile: blind controlled clinical trial.

Rev Lat Am Enfermagem 2018 Nov 29;26:e3075. Epub 2018 Nov 29.

Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Ribeirão Preto, SP, Brazil.

Objective: to evaluate the safety of a topical formulation containing chamomile microparticles coated with chitosan in the skin of healthy participants.

Method: phase I blind, controlled, non-randomized, single-dose clinical trial with control for skin, base formulation, and formulation with microparticles. The variables analyzed were irritation and hydration by the Wilcoxon and Kruskall-Wallis tests. Read More

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November 2018
5 Reads

Treatment of canine sarcoptic mange with afoxolaner (NexGard) and afoxolaner plus milbemycin oxime (NexGard Spectra) chewable tablets: efficacy under field conditions in Portugal and Germany.

Parasite 2018 5;25:63. Epub 2018 Dec 5.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, 83101 Rohrdorf, Germany.

The efficacy of NexGard and NexGard Spectra against sarcoptic mange in dogs was evaluated in a clinical field study. Skin scrapings from dogs presenting signs suggestive of sarcoptic mange were examined to confirm infestation. A total of 106 dogs were screened at eight sites in Portugal and Germany. Read More

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December 2018
1 Read

Bullous pemphigoid, a dermatosis of the elderly

Rev Prat 2017 12;67(10):1080-1083

Département de dermatologie, centre hospitalier universitaire de Rouen ; Inserm U1234, Institut de recherche et d'innovation biomédicale, université de Rouen, Rouen, France.

Bullous pemphigoid, a dermatosis of the elderly. Bullous pemphigoid is the most common autoimmune bullous disease and affects almost exclusively the elderly. Its occurrence is related to the presence of pathogenic autoantibodies directed against structural proteins (BP180 and BP230) of the protein adhesion complex of the dermo-epidermal junction: the hemi-desmosome. Read More

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December 2017
6 Reads

Pruritus of the elderly

Authors:
Laurent Misery

Rev Prat 2017 12;67(10):1076-1079

Service de dermatologie, CHU de Brest, Brest, France.

Pruritus of the elderly. Pruritus is defined as an unpleasant sensation that causes the need for scratching. In the elderly, it is frequently encountered. Read More

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December 2017
5 Reads

Heterotopic chondroid tissue of the main bile duct mimicking Klatskin tumor: case report and review of the literature.

Clin J Gastroenterol 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery, School of Medicine, İzmir Katip Çelebi University, İzmir, Turkey.

Heterotopic tissue in the bile duct is a very rare condition. There are a few case reports of heterotopic tissue including gastric and pancreatic cells. However, we could not find any data regarding heterotopic chondroid tissue obstructing the common bile duct in the literature. Read More

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November 2018
1 Read

Prevalence of chronic kidney disease-associated pruritus, and association with sleep quality among hemodialysis patients in Pakistan.

PLoS One 2018 29;13(11):e0207758. Epub 2018 Nov 29.

School of Pharmacy, Monash University, Jalan Lagoon Selatan, Selangor Darul Ehsan, Malaysia.

Background: The prevalence of chronic kidney disease-associated pruritus (CKD-aP) varies from 22% to 84% among patients receiving hemodialysis. It occurs more frequently at night, and often affects patient's sleep quality. CKD-aP is often unreported by patients, and many do not receive effective treatment. Read More

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November 2018
1 Read
3.234 Impact Factor

What is causing this pregnant woman's pruritus?

Authors:
Dayna Jaynstein

JAAPA 2018 Dec;31(12):55-56

Dayna Jaynstein is the assistant director of the PA program at Red Rocks Community College in Arvada, Colo., and practices emergency medicine in Denver, Colo. The author has disclosed no potential conflicts of interest, financial or otherwise.

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December 2018

Dry skin in home care: A representative prevalence study.

J Tissue Viability 2018 Nov 4;27(4):226-231. Epub 2018 Jul 4.

Charité-Universitätsmedizin Berlin, Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charitéplatz 1, 10117, Berlin, Germany; Ghent University, University Centre for Nursing and Midwifery, Department of Public Health, De Pintelaan 185, 9000, Gent, Belgium.

Aims And Objectives: To measure the prevalence and severity of dry skin in the home care nursing setting in Germany and to determine demographic and health characteristics associated with skin dryness.

Background: Advanced age and skin care dependency are risk factors for the development of skin dryness. Dry skin has a negative impact on the quality of life and increases the risk for secondary cutaneous infections and other adverse skin conditions. Read More

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November 2018

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, University of California, Irvine.

Importance: Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety of systemic pathways, including the immune system, in low doses of 1.5 to 4. Read More

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November 2018
4 Reads

Kombiglyze (metformin and saxagliptin)-induced hepatotoxicity in a patient with non-alcoholic fatty liver disease.

JGH Open 2018 Oct 1;2(5):242-245. Epub 2018 Oct 1.

Department of Pathology University Malaya Kuala Lumpur Malaysia.

A 33-year-old man was referred with hyperosmotic symptoms of 4 weeks. Clinical examination showed palpable hepatomegaly and no stigmata of liver disease. Findings were random glucose 16. Read More

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October 2018
4 Reads

Age-related differences in patient-reported outcomes in patients with advanced lung cancer receiving anti-PD-1/PD-L1 therapy.

Semin Oncol 2018 Aug 25;45(4):201-209. Epub 2018 Oct 25.

Oncology Center of Excellence, US Food and Drug Administration, Silver Spring, MD, USA.

Background: Older adults with lung cancer often have comorbidities that may increase risk of symptomatic adverse events (AEs) and physical function decline. The objective of this study was to examine age-related differences in patient-reported symptoms and functional domains in patients with advanced lung cancer receiving immunotherapy drugs.

Methods: Three randomized controlled trials of anti-programmed death receptor-1/programmed death-ligand 1 therapy in patients with advanced non-small cell lung cancer that included patient-reported outcomes (PROs) were identified. Read More

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Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES).

Trials 2018 Nov 27;19(1):657. Epub 2018 Nov 27.

University of Nottingham, Nottingham, UK.

Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy and presents with maternal pruritus, raised concentrations of serum bile acids and abnormal liver function tests. ICP is associated with increased rates of spontaneous and iatrogenic preterm labour, fetal hypoxia, meconium-stained amniotic fluid and intrauterine death. Some clinicians treat ICP with ursodeoxycholic acid (UDCA) to improve maternal pruritus and biochemical abnormalities. Read More

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November 2018
3 Reads

Lokivetmab therapy for pruritus in a dog with cutaneous mastocytosis.

Vet Dermatol 2018 Nov 26. Epub 2018 Nov 26.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA, 30602, USA.

Background: Cutaneous mastocytosis (CM) is a rare disease of dogs characterized by rash, pruritus and proliferation of mast cells in the skin. Oral H1 antihistamines are recommended as the treatment to control pruritus.

Hypothesis/objective: To describe the effective treatment of pruritus associated with CM with lokivetmab in one dog. Read More

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November 2018
7 Reads

Acupuncture improves symptoms in patients with mild-to-moderate atopic dermatitis: A randomized, sham-controlled preliminary trial.

Complement Ther Med 2018 Dec 10;41:90-98. Epub 2018 Sep 10.

Department of Ophthalmology, Otorhinolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Republic of Korea. Electronic address:

Objectives: To assess the feasibility of a definitive trial investigating the effects of acupuncture on atopic dermatitis symptoms including itching.

Design: A randomized, sham-controlled preliminary trial with three arms with a 4-week intervention period and a 4-week follow-up.

Interventions: Thirty participants were allocated to three arms (the verum acupuncture group 1 [VA1, 3 times weekly for 4 weeks], the verum acupuncture group 2 [VA2, twice weekly for 4 weeks], and the sham acupuncture group [SA, twice weekly for 4 weeks]) at a 1:1:1 ratio. Read More

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December 2018
4 Reads

A prospective study evaluating wound healing with sea cucumber gel compared with hydrogel in treatment of skin graft donor sites.

Complement Ther Med 2018 Dec 4;41:261-266. Epub 2018 Oct 4.

Reconstructive Sciences Unit, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia; Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.

Background: Gamat (sea-cucumber) is a natural occurring fauna which is popularly used as traditional medication in Southeast Asian countries. There have been many animal studies done on its' biochemical properties and its' effects in vivo. The effect of gamat on human cutaneous wounds was studied using a split-skin graft donor site wound. Read More

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December 2018

Dexmedetomidine as an Adjuvant to Local Anesthetics in Transversus Abdominis Plane Block: A Systematic Review and Meta-analysis.

Clin J Pain 2018 Nov 20. Epub 2018 Nov 20.

Department of Anesthesiology, The Second Hospital of Jilin University, Changchun 130041, China.

Objectives: The objective of this meta-analysis was to evaluate the analgesic effects of dexmedetomidine (DEX) in transversus abdominis plane (TAP) blocks for abdominal surgery.

Methods: Electronic databases, including PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan Fang, and the Cochrane Library , were conducted to collect the randomized controlled trials (RCTs) from inception to March 2018. RCTs investigating the impact of adding DEX to local anesthetics for TAP blocks were included in this analysis. Read More

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November 2018

Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients.

Sci Rep 2018 Nov 22;8(1):17251. Epub 2018 Nov 22.

Department of Nephrology and Clinical Poison Center, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Read More

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November 2018
8 Reads

Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report.

BMC Cancer 2018 Nov 20;18(1):1142. Epub 2018 Nov 20.

Department of Gastroenterology, University of Tsukuba Hospital, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Anal canal cancer occasionally accompanies extramammary Paget disease. Although most of them are squamous cell carcinoma, anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease has never been reported.

Case Presentation: Here, we report a 76-year-old man presented with pruritus in the perianal area. Read More

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November 2018
4 Reads