861 results match your criteria Pruritus and Systemic Disease


Pruritus in renal transplant recipients: Current state of knowledge.

Adv Clin Exp Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland.

Chronic itch (CI) is the most common symptom in dermatology. It is considered a great burden with a large impact on patients' quality of life, interfering with everyday activities. During the course of chronic kidney disease (CKD) many patients develop end-stage renal disease (ESRD)-associated CI (ESRDCI). Read More

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http://dx.doi.org/10.17219/acem/122174DOI Listing

Epidermolysis Bullosa Pruriginosa successfully treated with concomitant topical and systemic agents.

Australas J Dermatol 2020 Jun 10. Epub 2020 Jun 10.

Dermatology Department, Centro Hospital e Universitário do Porto, Porto, Portugal.

Epidermolysis bullosa pruriginosa, a genetic mechanobullous disease, manifests at birth or late in life and is characterised by intense pruritus, resulting in lichenified or nodular prurigo-like lesions and scarring most prominent on the shins. Treatment is unsatisfactory. We report a patient treated with success using a combination of topical and systemic agents. Read More

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http://dx.doi.org/10.1111/ajd.13342DOI Listing

Small molecule drugs for the treatment of pruritus in patients with atopic dermatitis.

Eur J Pharmacol 2020 Jun 3;881:173242. Epub 2020 Jun 3.

Dr. August Wolff GmbH & Co. KG Arzneimittel, Bielefeld, Germany. Electronic address:

Chronic pruritus is a cardinal symptom of the inflammatory skin disease atopic dermatitis (AD). Pathogenic mechanisms in the periphery, spinal cord and the brain have been implicated in AD-related pruritus. Therefore, both systemic and topical administration of drugs could potentially provide relief. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173242DOI Listing

GRANZYME B CONTRIBUTES TO BARRIER DYSFUNCTION IN OXAZOLONE-INDUCED SKIN INFLAMMATION THROUGH E-CADHERIN AND FILAGGRIN CLEAVAGE.

J Invest Dermatol 2020 Jun 3. Epub 2020 Jun 3.

International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, V5Z 1M9, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada; British Columbia Professional Firefighters' Burn and Wound Healing Group, Vancouver, BC, V5Z 1M9, Canada. Electronic address:

Atopic dermatitis (AD) is the most common inflammatory skin condition. Skin barrier dysfunction is of major importance in AD as it facilitates allergen sensitization and systemic allergic responses. Long regarded as a pro-apoptotic protease, emerging studies indicate granzyme B (GzmB) to have extracellular roles involving the proteolytic cleavage of extracellular matrix, cell adhesion- and basement membrane -proteins. Read More

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http://dx.doi.org/10.1016/j.jid.2020.05.095DOI Listing

Successful treatment of recalcitrant nodular prurigo with tofacitinib.

Clin Exp Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Dermatology, St. Vincent's University Hospital, Dublin, Ireland.

Nodular prurigo (NP) is a clinical description of characteristic secondary skin changes -excoriations and nodules- in response to pruritus. The underlying cause is unclear, but up to 80% of patients have atopy and a smaller number have systemic disease e.g. Read More

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http://dx.doi.org/10.1111/ced.14320DOI Listing

Prurigo Nodularis: Epidemiology and Clinical Features.

J Am Acad Dermatol 2020 May 23. Epub 2020 May 23.

Johns Hopkins University School of Medicine, Department of Dermatology; Johns Hopkins University Bloomberg School of Public Health. Electronic address:

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intensely pruritic, hyperkeratotic nodules that favor the extensor surfaces of the extremities and the trunk. In addition to its significant impact on quality of life, many patients with PN are recalcitrant to therapy as there are currently no FDA approved therapies. In the first article of this 2-part continuing medical education series, we describe the broader epidemiology, patient demographics, physical exam findings, and symptoms to aid in the timely recognition and diagnosis of PN. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.183DOI Listing

Cutaneous manifestations of anti-neutrophil cytoplasmic antibody-associated vasculitis.

Arthritis Rheumatol 2020 May 18. Epub 2020 May 18.

Division of Rheumatology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Objective: Cutaneous manifestations of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), are poorly characterized. This study describes the dermatologic features of AAV and their association with systemic manifestations of vasculitis.

Methods: A cross-sectional study describing and comparing the cutaneous manifestations of AAV was performed using data from a large, international, collaborative effort to collect comprehensive clinical data on patients with vasculitis. Read More

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http://dx.doi.org/10.1002/art.41310DOI Listing

Folliculotropic mycosis fungoides: Clinical characteristics, treatments, and long-term outcomes of 53 patients in a tertiary hospital.

Dermatol Ther 2020 May 14:e13585. Epub 2020 May 14.

Faculty of Medicine, Department of Pathology, Ankara University, Ankara, Turkey.

Folliculotropic mycosis fungoides (FMF) is characterized by a broad clinical spectrum and worse prognosis compared to classical MF. This study aimed to evaluate the clinical characteristics, treatment modalities and long-term outcome and risk factors for progression and survival of FMF patients. We conducted a single-center retrospective study and reviewed 53 patients diagnosed with FMF between 1990 to 2019 in a referral center at Ankara University, Turkey. Read More

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http://dx.doi.org/10.1111/dth.13585DOI Listing

A Monocentric, Retrospective Analysis of 61 Patients with Generalized Granuloma Annulare.

Dermatology 2020 May 13:1-6. Epub 2020 May 13.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Granuloma annulare is a chronic noninfectious granulomatous skin condition with variable clinical presentations. Generalized granuloma annulare, defined as widespread disease with >10 skin lesions, accounts for 15% of all cases. Numerous associated diseases have been controversially discussed, most importantly diabetes mellitus, dyslipidemia, thyroid disease, malignancy and systemic infections. Read More

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http://dx.doi.org/10.1159/000507247DOI Listing

[Topical therapy of pruritus-tips for daily practice].

Hautarzt 2020 Jul;71(7):511-517

Hautklinik, Universitätsmedizin Mainz, Mainz, Deutschland.

Pruritus is a common and stressful symptom in medicine with cutaneous manifestation. Therapy remains a challenge for physicians and patients because there are many causes/triggers and approved systemic therapies are lacking. Basically, there are two different options of treatment: topical treatment is selected for every degree of severity, while patients with severe symptoms and chronic disease course have to be treated with systemic and topical options. Read More

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http://dx.doi.org/10.1007/s00105-020-04605-3DOI Listing

Indoor salt water baths followed by artificial ultraviolet B light for chronic plaque psoriasis.

Cochrane Database Syst Rev 2020 May 5;5:CD011941. Epub 2020 May 5.

Department of Dermatology, Ruhr-Universität Bochum, Bochum, Germany.

Background: Chronic plaque psoriasis is an immune-mediated, chronic, inflammatory skin disease, which can impair quality of life and social interaction. Disease severity can be classified by the psoriasis area and severity index (PASI) score ranging from 0 to 72 points. Indoor artificial salt bath with or without artificial ultraviolet B (UVB) light is used to treat psoriasis, simulating sea bathing and sunlight exposure; however, the evidence base needs clear evaluation. Read More

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http://dx.doi.org/10.1002/14651858.CD011941.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199317PMC

PD-1 Blockade in Anaplastic Thyroid Carcinoma.

J Clin Oncol 2020 May 4:JCO1902727. Epub 2020 May 4.

Oregon Health & Science University, Portland, OR.

Purpose: Anaplastic thyroid carcinoma is an aggressive malignancy that is almost always fatal and lacks effective systemic treatment options for patients with -wild type disease. As part of a phase I/II study in patients with advanced/metastatic solid tumors, patients with anaplastic thyroid carcinoma were treated with spartalizumab, a humanized monoclonal antibody against the programmed death-1 (PD-1) receptor.

Methods: We enrolled patients with locally advanced and/or metastatic anaplastic thyroid carcinoma in a phase II cohort of the study. Read More

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http://dx.doi.org/10.1200/JCO.19.02727DOI Listing

Acquired reactive perforating collagenosis in association with prostate adenocarcinoma, chronic lymphocytic leukemia, and Graves' disease.

An Bras Dermatol 2020 May - Jun;95(3):336-339. Epub 2020 Apr 18.

Department of Dermatology and Venerology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Acquired reactive perforating collagenosis is a rare skin disorder characterized by the presence of umbilicated pruritic papules and nodules. Transepidermal elimination of altered and perforating bundles of basophilic collagen from the epidermis is a characteristic histologic feature of acquired reactive perforating collagenosis. Along with its well-known association with systemic diseases such as diabetes mellitus, chronic renal failure, and dermatomyositis, there are reports of acquired reactive perforating collagenosis being associated with malignancies. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253912PMC

Itch in the era of COVID-19 pandemic: An unfolding scenario.

Dermatol Ther 2020 May 1:e13477. Epub 2020 May 1.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

Coronavirus disease 2019 (COVID-19) is an infectious disease, caused by severe acute respiratory syndrome (SARS)-CoV-2, that broke out in December 2019. In just 4 months it has spread to almost every country in the world and up to April 18, 2020, the virus has infected more than two million people. Itch is the most common symptom in dermatology and a frequent one of systemic diseases. Read More

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http://dx.doi.org/10.1111/dth.13477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261994PMC

Classic and Non-classic (Surrepticius) Scabies: Diagnostic and Treatment Considerations.

Authors:
Philip R Cohen

Cureus 2020 Mar 25;12(3):e7419. Epub 2020 Mar 25.

Dermatology, San Diego Family Dermatology, National City, USA.

The morphology of scabies, a mite infestation of worldwide proportion, is characterized by a variety of cutaneous lesions. Patients with classic scabies present with characteristic burrows often located on the web spaces of the fingers and toes. Scabies surrepticius refers to the non-classic atypical presentation of scabies; establishing the diagnosis of scabies in these individuals can be difficult. Read More

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http://dx.doi.org/10.7759/cureus.7419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186094PMC

Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis.

Int J Mol Sci 2020 Apr 20;21(8). Epub 2020 Apr 20.

BK21plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Korea.

Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to occur primarily in children, increasing evidence suggests that AD is more common in adults than previously assumed. Accumulating evidence from experimental, genetic, and clinical studies indicates that AD expression is a precondition for the later development of other atopic diseases, such as asthma, food allergies, and allergic rhinitis. Read More

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http://dx.doi.org/10.3390/ijms21082867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215310PMC

[Tinea capitis in children is an overlooked disease].

Ugeskr Laeger 2020 Mar;182(11)

In this review, we discuss tinea capitis, which is a disease most prevalent in children and caused by dermatophytes infecting the hair and scalp. The clinical presentation varies from scaling and alopecia to inflammatory lesions with pain and pruritus. Treatment includes systemic and topical antifungal agents. Read More

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FDA Accelerated Approval of Pembrolizumab for Recurrent Locally Advanced or Metastatic Merkel Cell Carcinoma.

Oncologist 2020 Apr 9. Epub 2020 Apr 9.

Office of Oncologic Diseases, Silver Spring, Maryland, USA.

On December 19, 2018, the Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA, Merck & Co. Inc., Whitehouse Station, NJ) for adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0184DOI Listing

A Systematic Review of Drug-Induced Pemphigoid.

Acta Derm Venereol 2020 Mar 16. Epub 2020 Mar 16.

School of Medicine, University of Notre Dame, Sydney, Australia.

Bullous pemphigoid is an autoimmune subepithelial disease characterised by pruritus followed by urticarial plaques and finally bullae on the skin and mucosa. Drug-associated bullous pemphigoid (DABP) is a term used to describe instances of bullous pemphigoid demonstrating clinical, histological, or immunopathological features identical or similar to those of the idiopathic form of bullous pemphigoid, associated with the systemic ingestion, or topical application of particular drugs. In this study, we conducted a comprehensive search of the literature according to PRISMA guidelines and a total of 170 publications were included in the final qualitative analysis. Read More

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http://dx.doi.org/10.2340/00015555-3457DOI Listing

Identification of a novel autoantibody against heat shock factor 1 in idiopathic inflammatory myopathy.

Clin Exp Rheumatol 2020 Mar 5. Epub 2020 Mar 5.

Department of Rheumatology, Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing, China.

Objectives: Myositis autoantibodies show great utility in the diagnosis and clinico-serological phenotyping of idiopathic inflammatory myopathy (IIM). We identified a novel autoantibody against heat shock factor 1 (HSF1) and further evaluated its disease specificity and clinical significance in IIM patients.

Methods: A human protein microarray was used to identify autoantibodies in myositis sera. Read More

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The central role of endothelium in hereditary angioedema due to C1 inhibitor deficiency.

Int Immunopharmacol 2020 Feb 27;82:106304. Epub 2020 Feb 27.

Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, Milan, Italy; IRCCS-ICS Maugeri, Milan, Italy.

An impairment of the endothelial barrier function underlies a wide spectrum of pathological conditions. Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) can be considered the "pathophysiological and clinical paradigm" of Paroxysmal Permeability Diseases (PPDs), conditions characterized by recurrent transient primitively functional alteration of the endothelial sieving properties, not due to inflammatory-ischemic-degenerative injury and completely reversible after the acute flare. It is a rare yet probably still underdiagnosed disease which presents with localized, non-pitting swelling of the skin and submucosal tissues of the upper respiratory and gastrointestinal tracts, without significant wheals or pruritus. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106304DOI Listing
February 2020

Therapeutic Potential of Lebrikizumab in the Treatment of Atopic Dermatitis.

J Asthma Allergy 2020 11;13:109-114. Epub 2020 Feb 11.

University of Arizona, Division of Dermatology, Tucson, AZ, USA.

Background: Atopic dermatitis (AD) is a chronic, relapsing skin condition with a wide disease spectrum. Moderate-to-severe cases often need systemic treatment. Conventional immunosuppressants have extensive side effect profiles and require close monitoring. Read More

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http://dx.doi.org/10.2147/JAA.S211032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023853PMC
February 2020

Safety considerations when using drugs to treat pruritus.

Expert Opin Drug Saf 2020 Apr 17;19(4):467-477. Epub 2020 Feb 17.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.

: Treatment for chronic pruritus ranges from use of topical formulations to newer biologic agents. Targeting treatment to the underlying etiology is key in reducing the burden of disease while avoiding systemic or adverse effects.: This review details the effective medical treatments used in various etiologies of chronic itch with a focus on the potential adverse effects and safety data available for each. Read More

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http://dx.doi.org/10.1080/14740338.2020.1728252DOI Listing

An overview of drug discovery efforts for eczema: why is this itch so difficult to scratch?

Expert Opin Drug Discov 2020 Apr 13;15(4):487-498. Epub 2020 Feb 13.

Centre for Learning Enhancement And Research, The Chinese University of Hong Kong, Shatin, Hong Kong.

: Atopic dermatitis (AD) is a type of allergic/inflammatory dermatitis characterized by itch and an impairment in quality of life.: Herein, the authors review drug discovery efforts for AD, highlighting the clinical efficacy of novel drugs, with a particular focus on the relief of pruritus. Topical agents include emollients, topical antihistamines, corticosteroids, calcineurin inhibitors and herbs. Read More

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http://dx.doi.org/10.1080/17460441.2020.1722639DOI Listing
April 2020
3.467 Impact Factor

Spinal GRPR and NPRA Contribute to Chronic Itch in a Murine Model of Allergic Contact Dermatitis.

J Invest Dermatol 2020 Feb 5. Epub 2020 Feb 5.

The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Center for Immunology, Inflammation, and Immune-mediated disease, Guangzhou Medical University, Guangzhou, China. Electronic address:

Recurrent and intractable chronic itch is a worldwide problem, but mechanisms, especially the neural mechanisms, underlying chronic itch still remain unclear. In this study, we investigated the peripheral and spinal mechanisms responsible for prolonged itch in a mouse model of allergic contact dermatitis induced by squaric acid dibutylester. We found that repeated exposure of mice to squaric acid dibutylester evoked persistent spontaneous scratching and significantly aberrant cutaneous and systemic immune responses lasting for weeks. Read More

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http://dx.doi.org/10.1016/j.jid.2020.01.016DOI Listing
February 2020

Dyskeratotic cells in persistent pruritic skin lesions as a prognostic factor in adult-onset Still disease.

Medicine (Baltimore) 2020 Feb;99(6):e19051

Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School Hospital, Nankoku.

Adult-onset Still disease (AOSD), a systemic inflammatory disorder, is characterized by high fever, evanescent rash, arthritis, and hyperferritinaemia. AOSD is also reported to be associated with other skin lesions, including persistent pruritic papules and plaques. This study aimed to assess the significance of dyskeratotic skin lesions in Japanese AOSD patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000019051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015626PMC
February 2020

Pruritus in pediatric patients with atopic dermatitis: a multidisciplinary approach - summary document from an Italian expert group.

Ital J Pediatr 2020 Jan 30;46(1):11. Epub 2020 Jan 30.

Unit of Pediatrics, Fatebenefratelli Hospital, Benevento, Italy.

Given the inadequate overall awareness of the main disease features and treatment modalities of pruritus in pediatric patients with atopic dermatitis, a multidisciplinary Italian expert group met with the major aim of increasing knowledge of the condition for improved diagnosis and better management among specialists involved in disease management. Herein, the overall features of the condition are reviewed, along with its etiopathogenesis and symptoms. Likewise, management options are summarized, emphasizing the need for a multidisciplinary approach, minimally composed of a management team that includes a pediatrician, dermatologist, psychologist, play assistant, and dedicated nurse. Read More

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http://dx.doi.org/10.1186/s13052-020-0777-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993480PMC
January 2020

Cannabinoids for the treatment of chronic pruritus: A review.

J Am Acad Dermatol 2020 May 25;82(5):1205-1212. Epub 2020 Jan 25.

Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Medical marijuana is becoming widely available to patients in the United States, and with recreational marijuana now legalized in many states, patient interest is on the rise. The endocannabinoid system plays an important role in skin homeostasis in addition to broader effects on neurogenic responses such as pruritus and nociception, inflammation, and immune reactions. Numerous studies of in vitro and animal models have provided insight into the possible mechanisms of cannabinoid modulation on pruritus, with the most evidence behind neuronal modulation of peripheral itch fibers and centrally acting cannabinoid receptors. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.01.036DOI Listing

Interventions for chronic pruritus of unknown origin.

Cochrane Database Syst Rev 2020 01 25;1:CD013128. Epub 2020 Jan 25.

Instituto Universitario Hospital Italiano, Argentine Cochrane Centre, Potosi 4234, Buenos Aires, Buenos Aires, Argentina, C1199ACL.

Background: Pruritus is a sensation that leads to the desire to scratch; its origin is unknown in 8% to 15% of affected patients. The prevalence of chronic pruritus of unknown origin (CPUO) in individuals with generalised pruritus ranges from 3.6% to 44. Read More

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http://dx.doi.org/10.1002/14651858.CD013128.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984650PMC
January 2020

Innovation in Atopic Dermatitis: From Pathogenesis to Treatment.

Actas Dermosifiliogr 2020 Apr 20;111(3):205-221. Epub 2020 Jan 20.

Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, España.

Atopic dermatitis is the most common inflammatory skin disease and up to 20% of cases can be classified as moderate to severe. Our understanding of the pathogenesis of this disease has improved in recent years. The process is primarily driven by the Th2 pathway, but with significant contributions from the Th22 pathway, the Th1 and Th17 axes, epidermal barrier dysfunction, pruritus, and JAK/STAT signaling. Read More

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http://dx.doi.org/10.1016/j.ad.2019.11.002DOI Listing

Interventions for chronic palmoplantar pustulosis.

Cochrane Database Syst Rev 2020 01 20;1:CD011628. Epub 2020 Jan 20.

Hôpital Henri Mondor, Department of Dermatology, 51 avenue du Général de Lattre de Tassigny, Créteil, France, 94010.

Background: Palmoplantar pustulosis is a chronic inflammatory disease in which sterile, relapsing pustules appear on the palms and soles, possibly in conjunction with other symptoms. The previous Cochrane Review on this topic was published in 2006, before biological treatments were extensively used.

Objectives: To assess the effects of interventions for chronic palmoplantar pustulosis to induce and maintain complete remission. Read More

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http://dx.doi.org/10.1002/14651858.CD011628.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984641PMC
January 2020

Safety of Timothy Grass Sublingual Immunotherapy Tablet in Children: Pooled Analyses of Clinical Trials.

J Allergy Clin Immunol Pract 2020 Apr 15;8(4):1387-1393.e2. Epub 2020 Jan 15.

Medical College of Georgia at Augusta University, Augusta, Ga.

Background: Timothy grass sublingual immunotherapy (SLIT) tablets are indicated for children with allergic rhinitis with or without conjunctivitis.

Objective: To use pooled analyses to assess the short- and long-term tolerability and safety of timothy grass SLIT-tablet in children.

Methods: Data from 9 double-blinded, randomized European or North American trials that included children with allergic rhinitis with or without conjunctivitis treated up to 3 years with once-daily timothy grass SLIT-tablet or placebo were pooled. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.01.008DOI Listing

Palliative radiotherapy for hepatobiliary obstruction caused by colorectal metastases.

J Gastrointest Oncol 2019 Dec;10(6):1157-1161

Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.

Hyperbilirubinemia in the setting of stent-intolerant biliary obstruction is a challenging problem and can prevent cancer patients from pursuing additional treatments such as further systemic therapies. We report a case of a 75-year-old female who underwent treatment with palliative radiotherapy (RT) for relieving persistent biliary obstruction secondary to liver metastases from colorectal disease, despite prior appropriate stent placement. Prior to RT, the patient's total bilirubin was 14. Read More

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http://dx.doi.org/10.21037/jgo.2019.09.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955015PMC
December 2019

Non-dermatological Challenges of Chronic Itch.

Acta Derm Venereol 2020 01;100(2):adv00025

Chronic itch occurs in many skin diseases, but also in a variety of systemic, neurological, and psychogenic/psychosomatic disorders, or is caused by drug intake. When several diseases or causes co-exist, chronic itch is categorized as "mixed origin". These patients present with unaltered skin or with chronic scratch lesions including chronic prurigo. Read More

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http://dx.doi.org/10.2340/00015555-3345DOI Listing
January 2020

Clinical features and disease management of adult patients with atopic dermatitis receiving care at reference hospitals in Brazil: the ADAPT Study.

J Investig Allergol Clin Immunol 2020 01 14. Epub 2020 Jan 14.

Sanofi Genzyme, São Paulo, Brazil.

Background And Objectives: Atopic dermatitis is a chronic inflammatory skin disease with a prevalence of 0.02% to 8.1% in adults. Read More

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http://dx.doi.org/10.18176/jiaci.0478DOI Listing
January 2020

Yeast extract demonstrates rapid itch relief in chronic pruritus.

J Cosmet Dermatol 2020 Jan 10. Epub 2020 Jan 10.

Department of Dermatology, Hairmore Hospital Beijing, Beijing, China.

Background: Pruritus is the most common complaint encountered in dermatological practice. It is estimated that up to 4% of the world population suffers from chronic itch. Chronic pruritus can be associated with both cutaneous or systemic conditions. Read More

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http://dx.doi.org/10.1111/jocd.13265DOI Listing
January 2020

Occurrence of an Abscopal Radiation Recall Phenomenon in a Glioblastoma Patient Treated with Nivolumab and Re-Irradiation.

Case Rep Oncol 2019 Sep-Dec;12(3):896-900. Epub 2019 Nov 27.

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.

Glioblastoma multiforme is the most frequent primary brain tumor. The clinical course of glioblastoma is almost invariably fatal. Combined chemo-irradiation with temozolomide is currently the standard of care for newly diagnosed glioblastoma and concurrent Nivolumab, an anti-PD-1 monoclonal antibody is being studied for de novo glioblastoma. Read More

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http://dx.doi.org/10.1159/000504698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940433PMC
November 2019

Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions.

Evid Based Complement Alternat Med 2019 7;2019:8359252. Epub 2019 Dec 7.

Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou, Guangdong, China.

Atopic dermatitis (AD), also known as atopic eczema, is a chronic pruritic inflammatory skin disease. The available systemic therapies for atopic dermatitis are inadequate. . Read More

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http://dx.doi.org/10.1155/2019/8359252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925805PMC
December 2019

Acquired perforating dermatosis: clinicopathologic study of a 10-year period at a tertiary teaching hospital.

Int J Dermatol 2020 Apr 26;59(4):445-450. Epub 2019 Dec 26.

Dermatology Department, Centro Hospitalar Universitário Lisboa Norte, EPE (CHULN), Lisboa, Portugal.

Background: Acquired perforating dermatosis (APD) comprises an uncommon group of skin disorders that develop in adulthood in association with systemic diseases. The aim of this study was to characterize clinicopathologic features and treatment outcomes in a series of patients diagnosed with APD.

Methods: Retrospective study of all patients diagnosed with an APD over a 10-year period (2009-2018) at a tertiary teaching hospital in Lisbon, Portugal. Read More

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http://dx.doi.org/10.1111/ijd.14760DOI Listing

Pruritus as a sign of systemic disease.

Clin Dermatol 2019 Nov - Dec;37(6):644-656. Epub 2019 Jul 31.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland. Electronic address:

Pruritus, as one of the most common clinical manifestations in medicine, has been recognized for many centuries. Defined as an unpleasant sensation resulting in the need to scratch, it is divided into acute and chronic stages, based on the duration of the clinical manifestation. Classically, pruritus is associated with cutaneous disorders; however, it may also accompany various systemic disorders, including renal, hepatic, hematologic, or oncologic, and be the first or solitary manifestation of an underlying systemic disease. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.031DOI Listing

PRURITUS CHARACTERISTICS IN A LARGE ITALIAN COHORT OF PSORIATIC PATIENTS.

J Eur Acad Dermatol Venereol 2019 Jul 5;33(7):1316-1324. Epub 2019 Mar 5.

Centro Studi GISED, Bergamo, Italy.

Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64-98% of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus.

Objective: To investigate factors associated with Ps pruritus intensity. Read More

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http://dx.doi.org/10.1111/jdv.15539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857445PMC

Baseline characteristics, disease severity and treatment history of patients with atopic dermatitis included in the German AD Registry TREATgermany.

J Eur Acad Dermatol Venereol 2020 Jun 13;34(6):1263-1272. Epub 2020 Feb 13.

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

Background: The Atopic Dermatitis (AD) TREATgermany registry was initiated by the German Society for Dermatology (DDG) in 2011 to evaluate the 'real-life' situation of health care for patients with AD.

Objectives: Interim data analysis on baseline characteristics as well as current and prescribed systemic treatments of the TREATgermany registry patients.

Methods: Patients (≥18 years) with moderate-to-severe AD [objective (o)SCORAD > 20], or with current or previous anti-inflammatory systemic treatment for AD within 24 months, were included and are followed up over at least 24 months. Read More

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http://dx.doi.org/10.1111/jdv.16078DOI Listing
June 2020
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Postherpetic Pruritus: A Potential Complication of Herpes Zoster Virus Infection.

Cureus 2019 Sep 16;11(9):e5665. Epub 2019 Sep 16.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Postherpetic pruritus is an uncommon adverse sequela of Varicella zoster infection. It can present with or without prior postherpetic neuralgia. A 57-year-old woman who developed persistent postherpetic pruritus following a Varicella zoster infection, affecting the skin between her right thoracic fifth to eighth dermatomes is described; she did not have postherpetic neuralgia. Read More

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http://dx.doi.org/10.7759/cureus.5665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823016PMC
September 2019

Idiopathic anaphylaxis.

Allergy Asthma Proc 2019 11;40(6):457-461

Idiopathic anaphylaxis (IA) is defined as anaphylaxis without any identifiable precipitating agent or event. The clinical manifestations of IA are the same as allergen-associated (immunologic) anaphylaxis and include urticaria, angioedema, hypotension, tachycardia, wheezing, stridor, pruritus, nausea, vomiting, flushing, diarrhea, dysphagia, light-headedness, and loss of consciousness. Patients usually tend to have the same manifestations on repeated episodes. Read More

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http://dx.doi.org/10.2500/aap.2019.40.4271DOI Listing
November 2019
6 Reads

The use of selective Th2 blocker dupilumab for the treatment of atopic dermatitis in a heart transplant patient: Case report.

Dermatol Ther 2019 11 11;32(6):e13144. Epub 2019 Nov 11.

Department of Dermatology, University of Florida, Gainesville, Florida.

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by relapsing eczematous rash with severe pruritus and recurrent infection. Topical emollients and immune-modulators (e.g. Read More

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http://dx.doi.org/10.1111/dth.13144DOI Listing
November 2019

[Fatal outcome of Netherton syndrome due to excessive use of topical corticosteroids in an adult patient].

Ann Dermatol Venereol 2020 Jan 22;147(1):36-40. Epub 2019 Oct 22.

Hôpital Larrey, 24, chemin de Pouvourville, 31400 Toulouse, France.

Introduction: Netherton syndrome (NS) is a rare disease caused by SPINK5 mutations associated with ichthyosis (erythroderma and desquamation), alopecia and atopic manifestations. There are no effective treatments. Topical corticosteroids may be used for a limited period in the event of eczema. Read More

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http://dx.doi.org/10.1016/j.annder.2019.09.003DOI Listing
January 2020

Principles of prophylactic and therapeutic management of skin toxicity during treatment with checkpoint inhibitors.

Postepy Dermatol Alergol 2019 Aug 30;36(4):382-391. Epub 2019 Aug 30.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Skłodowska-Curie Institute - Oncology Center, Warsaw, Poland.

The introduction of immunotherapy into the treatment of cancer patients has revolutionised the oncological approach and significantly improved patient survival. The key drugs are immune checkpoint inhibitors (CPIs), whose mechanism of action is to elicit immune response against cancer cell antigens. Three types of CPIs are currently used and approved: an anti-CTLA-4 antibody, ipilimumab; anti-PD-1 antibodies, nivolumab and pembrolizumab; and anti-PD-L1 antibodies: atezolizumab, avelumab and durvalumab. Read More

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http://dx.doi.org/10.5114/ada.2018.80272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791150PMC
August 2019
2 Reads

The patient-reported disease burden in adults with atopic dermatitis: a cross-sectional study in Europe and Canada.

J Eur Acad Dermatol Venereol 2020 May 14;34(5):1026-1036. Epub 2020 Jan 14.

Sanofi, Chilly-Mazarin, France.

Background: Cross-sectional data on patient burden in adults with atopic dermatitis (AD) from real-world clinical practice are limited.

Objective: This study compared patient-reported burden associated with adult AD across severity levels from clinical practices in Canada and Europe.

Methods: This study included adults (18-65 years) diagnosed with AD by dermatologists, general practitioners or allergists. Read More

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http://dx.doi.org/10.1111/jdv.16003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318704PMC
May 2020
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Characterizing Pruritus in Autoimmune Connective Tissue Diseases

J Drugs Dermatol 2019 Oct;18(10):995-998

Background: Autoimmune connective tissue diseases (ACTDs) are a broad range of diseases featured by immune dysregulation, and often have multisystem involvement with prominent skin manifestations. Pruritus is one of the most common symptoms in these diseases, with significant impact on the quality of life of patients. Objective: To characterize the frequency, location, severity, and timing relative to disease onset of pruritus in different ACTDs. Read More

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October 2019
4 Reads