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    647 results match your criteria Pruritus and Systemic Disease

    1 OF 13

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    A Phase 1 clinical trial demonstrates nfP2X7 targeted antibodies provide a novel, safe and tolerable topical therapy for BCC.
    Br J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Biosceptre (Aust) Pty Ltd, 11 Julius Avenue, North Ryde, NSW 2113, Australia.
    Background: Expression of P2X7 , an ATP gated calcium channel, increases cancer cell proliferation and invasiveness. A variant of P2X7 (termed nfP2X7 ), in which a normally hidden epitope (E200) is exposed for antibody binding, is observed in a variety of different cancers.

    Objectives: To investigate the safety, tolerability and pharmacokinetics and assess indicative efficacy of a novel antibody ointment as a therapeutic for BCC. Read More

    Clinical Features, Response to Treatment, and Outcomes of IgG4-related Sclerosing Cholangitis.
    Clin Gastroenterol Hepatol 2017 Jan 19. Epub 2017 Jan 19.
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
    Background & Aims: Immunoglobulin G4 sclerosing cholangitis (IgG4SC) is a biliary tract manifestation of IgG4-related systemic disease. We investigated the demographics, clinical features at presentation, treatment response, and outcomes of IgG4-SC using data from a large-scale survey in Japan.

    Methods: We performed a retrospective cohort study of 527 patients with IgG4-SC (436 female; median age, 66. Read More

    Clinical features of shiitake dermatitis: a systematic review.
    Int J Dermatol 2017 Jan 4. Epub 2017 Jan 4.
    Department of Dermatology, Mayo Clinic Florida, Jacksonville, FL, USA.
    Shiitake dermatitis is a rare cutaneous reaction to lentinan, a polysaccharide component in the cell walls of shiitake mushrooms (Lentinula edodes). Herein, we systematically review the case report and case series English-language literature on shiitake dermatitis, which refers to a total of 50 patients (38 males, 12 females; mean age: 44.58 years). Read More

    Systemic Mastocytosis Causing Refractory Pruritus in a Liver Disease Patient.
    ACG Case Rep J 2016 Aug 23;3(4):e152. Epub 2016 Nov 23.
    Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR.
    Systemic mastocytosis (SM) results from clonal, neoplastic proliferation of abnormal mast cells. Patients become susceptible to itching, urticaria, and anaphylactic shock, which occurs due to histamine release from mast cells. SM may coexist alongside other systemic diseases, thus confounding the overall clinical presentation. Read More

    [Cutaneous manifestations in renal diseases].
    Hautarzt 2016 Dec;67(12):960-969
    Dermatologische Abteilung, Donauspital, Langobardenstr. 122, 1220, Wien, Österreich.
    In addition to general skin changes like pallor or dryness and the frequent, often excruciating nephrogenic pruritus, specific diseases in patients with renal failure may occur. Acquired perforating dermatoses are usually also highly pruritic. Calciphylaxis is a severe disease with poor prognosis. Read More

    [Diffuse cutaneous mastocytosis of an infant: A case report].
    Arch Pediatr 2016 Nov 23;23(11):1150-1152. Epub 2016 Sep 23.
    Service de dermatologie, centre hospitalier universitaire Ibn Sina, rue Famfdal Cherkaoui, BP 6527, 10000 Rabat, Maroc.
    Mastocytosis is a group of diseases related to abnormal accumulation and proliferation of mast cells in one or more organs. They may be associated with an acquired point mutation and the activation of the receptor tyrosine-kinase c-KIT of CFS (mast cell growth factor). The clinical manifestations are varied and secondary to the release of mast cell mediators and/or infiltration of various organs. Read More

    Small animal disease surveillance: pruritus, and coagulase-positive staphylococci.
    Vet Rec 2016 Oct;179(14):352-355
    BSAVA, Woodrow House, 1 Telford Way, Waterwells Business Park, Quedgeley, Gloucestershire GL2 2AB, UK.
    Presentation for pruritus comprised 6.5 per cent, 3.6 per cent and 2. Read More

    African American race associated with body image dissatisfaction among patients with systemic sclerosis.
    Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):70-73. Epub 2016 May 10.
    Georgetown University Medical Center, Washington, DC, USA.
    Objectives: Studies have shown a high degree of body image dissatisfaction among patients with systemic sclerosis (SSc). We aimed to identify demographic and phenotypic characteristics that correlate with body image dissatisfaction.

    Methods: Ninety-eight patients with SSc were recruited from Georgetown University Medical Center 2003-2004. Read More

    Pruritus in selected dermatoses.
    Eur Rev Med Pharmacol Sci 2016 Sep;20(17):3628-41
    Department of Dermatology, University of Medical Sciences, Poznan, Poland.
    Pruritus is a natural defence mechanism of the body and creates the scratch reflex as a defensive reaction to potentially dangerous environmental factors. Together with pain, pruritus is a type of superficial sensory experience. Pruritus is a symptom often experienced both in healthy subjects and in those who have symptoms of a disease. Read More

    Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment.
    Dermatol Pract Concept 2016 Jul 31;6(3):31-8. Epub 2016 Jul 31.
    Department of Dermatology, University of California San Diego, San Diego, California.
    Background: Mastocytosis is either cutaneous (with skin-limited proliferation of mast cells) or systemic (with mast cells in extracutaneous sites). The onset of solitary mastocytoma in an adult is rare.

    Purpose: A woman with the new onset of solitary mastocytoma is described. Read More

    Clinical Efficacy of Romidepsin in Tumor Stage and Folliculotropic Mycosis Fungoides.
    Clin Lymphoma Myeloma Leuk 2016 Nov 10;16(11):637-643. Epub 2016 Aug 10.
    Kings College London, St John's Institute of Dermatology, London, United Kingdom.
    Background: Tumor stage and folliculotropic mycosis fungoides are uncommon subtypes of cutaneous T-cell lymphoma (CTCL) with an aggressive disease course. Romidepsin is a histone deacetylase inhibitor approved by the US Food and Drug Administration for patients with CTCL who have received ≥ 1 previous systemic therapy. In the present study, we examined the efficacy and safety of romidepsin in patients from the pivotal, single-arm, open-label, phase II study of relapsed or refractory CTCL with cutaneous tumors and/or folliculotropic disease involvement. Read More

    Induction of Immune Response after Allogeneic Wilms' Tumor 1 Dendritic Cell Vaccination and Donor Lymphocyte Infusion in Patients with Hematologic Malignancies and Post-Transplantation Relapse.
    Biol Blood Marrow Transplant 2016 Dec 12;22(12):2149-2154. Epub 2016 Sep 12.
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
    Relapse of hematologic malignancies is the primary cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HCT). Treatment for post-HCT relapse using donor lymphocyte infusion (DLI) has limited utility, particularly in the setting of acute leukemia, and can result in the development of graft-versus-host disease (GVHD). The Wilms' tumor 1 (WT1) gene product is a tumor-associated antigen that is expressed in acute leukemia and other hematologic malignancies, with limited expression in normal tissues. Read More

    Inducible urticaria: Case series and literature review.
    Biomedica 2016 Mar 3;36(1):10-21. Epub 2016 Mar 3.
    Grupo de Alergología Clínica y Experimental (GACE), IPS Universitaria, Universidad de Antioquia, Medellín, Colombia.
    Inducible urticaria is a heterogeneous group of skin disorders characterized by the appearance of wheals, pruritus and/or angioedema, sometimes accompanied by systemic symptoms caused by innocuous stimuli (cold, heat, pressure, etc.). This group of disorders compromises people's quality of life and most of the literature in this regard comes from case reports and case series since its epidemiology has been poorly studied and some cases are very rare. Read More

    Spinal dorsal horn astrocytes: New players in chronic itch.
    Allergol Int 2017 Jan 30;66(1):31-35. Epub 2016 Aug 30.
    Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:
    Chronic itch is a debilitating symptom of inflammatory skin conditions, such as atopic dermatitis, and systemic diseases, for which existing treatment is largely ineffective. Recent studies have revealed the selective neuronal pathways that are involved in itch sensations; however, the mechanisms by which itch turns into a pathological chronic state are poorly understood. Recent advances in our understanding of the mechanisms producing chronic itch have been made by defining causal roles for astrocytes in the spinal dorsal horn in mouse models of chronic itch including atopic dermatitis. Read More

    Pruritus Reduction with Systemic Anti-lymphoma Treatments in Patients with Cutaneous T Cell Lymphoma: A Narrative Review.
    Dermatol Ther (Heidelb) 2016 Dec 2;6(4):579-595. Epub 2016 Sep 2.
    University of Arkansas, Little Rock, AR, USA.
    Cutaneous T-cell lymphomas (CTCL) are a heterogeneous and relatively rare group of non-Hodgkin lymphomas arising from neoplastic skin-homing memory T cells. There is no known cure for CTCL, and current treatments focus on achieving and maintaining remission, controlling symptoms, limiting toxicities and maintaining or improving quality of life. Patients with CTCL often suffer from pruritus (itching), which can be debilitating and can have a significant impact on physical well-being and quality of life. Read More

    Prurigo Nodularis Management.
    Curr Probl Dermatol 2016 23;50:94-101. Epub 2016 Aug 23.
    Characterized by the clinical presentation of individual to multiple symmetrically distributed, hyperkeratotic, and intensely itchy papules and nodules, prurigo nodularis (PN) is a rare disease that emerges in patients with chronic pruritus due to continuous scratching over a long period of time. The itching and scratching of the lesions contribute to the vicious cycle that makes this disease difficult to treat, thus reducing the quality of life of affected patients. The pathogenesis of PN is ambiguous, although immunoneuronal crosstalk is implicated. Read More

    Itch and systemic sclerosis: frequency, clinical characteristics and consequences.
    Br J Dermatol 2016 Aug 22. Epub 2016 Aug 22.
    Department of Dermatology, University Hospital of Brest, Brest, France.
    Systemic sclerosis (SSc) is an autoimmune disease characterized by the excessive production of collagen (1). Itch is not usually considered to be a symptom of SSc. However, in a recent study, itch was a common symptom of SSc (42. Read More

    Treatment of ichthyosis lamellaris using a series of herbal skin care products family.
    J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):65-72
    Chair of Dermatology, University of Rome “G. Marconi” Rome, Italy.
    Lamellar ichthyosis (LI) is a genetically heterogeneous group of disorders of keratinization that are inherited in an autosomal recessive fashion, occurring in approximately 1 in 300,000 live births. The treatment of the large, dark, plate-like scales that characterize the classic manifestation of the disease are still a challenge. The aim of this study was to evaluate the efficacy and tolerability of Dr. Read More

    Current and Emerging Therapies for Itch Management in Psoriasis.
    Am J Clin Dermatol 2016 Dec;17(6):617-624
    Department of Dermatology and Itch Center, Lewis Katz School of Medicine at Temple University, 3322 North Broad Street, Medical Office Building, Suite 212, Philadelphia, PA, 19140, USA.
    Pruritus is a common and significant symptom among patients with psoriasis. Pruritus is often present beyond the borders of psoriatic plaques, and frequently affects the scalp and genital regions. Psoriatic itch may be severe and can profoundly affect quality of life and sleep, even in the context of mild-to-moderate disease. Read More

    DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: case report
    Int J Clin Pharmacol Ther 2016 Oct;54(10):808-15
    Objective: To report a rare case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by antituberculosis (TB) drugs, which progressed to acute generalized exanthematous pustulosis (AGEP) after moxifloxacin treatment.

    Case Summary: A 25-year-old female was hospitalized for dyspnea and dizziness. She had a history of TB and experienced rifampin-induced skin rash. Read More

    UVA1 phototherapy in the treatment of palmoplantar pustulosis: a pilot prospective study.
    Lasers Med Sci 2016 Nov 20;31(8):1641-1643. Epub 2016 Jul 20.
    Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
    Palmoplantar pustulosis (PPP) is recalcitrant to traditional topical and systemic therapies. Ultraviolet A1 (UVA1) phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of PPP. The purpose of this study was to evaluate the efficacy and safety of UVA1 therapy for the treatment of PPP. Read More

    New drugs in cutaneous T-cell lymphomas.
    Curr Opin Oncol 2016 Sep;28(5):384-9
    Department Dermatology, University Hospital Birmingham, Birmingham, United Kingdom.
    Purpose Of Review: Currently, there are no curative therapies for cutaneous T-cell lymphoma (CTCL), and consecutive treatments tend to be given until loss of response. There is an urgent need for new and improved therapies in CTCL to treat symptoms such as pruritus and painful skin lesions and prolong survival. This article reviews new drugs available for CTCL. Read More

    Advancement in management of epidermolysis bullosa.
    Curr Opin Pediatr 2016 Aug;28(4):507-16
    Department of Dermatology, Stanford University, Stanford, California, USA.
    Purpose Of Review: Epidermolysis bullosa is a hereditary skin disorder characterized by skin fragility. However, the disease can manifest in many different organ systems, therefore children born with epidermolysis bullosa may have life long, complex medical needs. In this review, we will use a system-based approach to highlight important aspects of disease management and recent advancements in each of the areas. Read More

    Effects of systematic nursing instruction on a low-phosphorus diet, serum phosphorus level and pruritus of patients on haemodialysis.
    J Clin Nurs 2017 Feb 15;26(3-4):485-494. Epub 2016 Aug 15.
    Master Program in Long-term Care and School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
    Aims And Objectives: To investigate the effectiveness of systematic nursing instruction on a low-phosphorus diet, serum phosphorus level and pruritus of haemodialysis patients.

    Background: A high number of end-stage renal disease patients on haemodialysis are bothered by pruritus. Hyperphosphataemia was reported to be related to pruritus. Read More

    [Pruritus in systemic diseases : Common and rare etiologies].
    Hautarzt 2016 Aug;67(8):606-14
    DKD Helios Kliniken Wiesbaden, Aukammallee 33, 65191, Wiesbaden, Deutschland.
    Chronic pruritus is a symptom of various internal disorders. In contrast to dermatological diseases, pruritus does not present with primary skin alterations in these patients. However, intense scratching may cause secondary skin changes such as abrasion, excoriation, prurigo nodularis, or in rare cases even scaring. Read More

    Chronic Pruritus and Connective Tissue Disorders: Review, Gaps, and Future Directions.
    Am J Clin Dermatol 2016 Oct;17(5):445-449
    Department of Dermatology and Itch Center, Lewis Katz Medical School Temple University, 3322 North Broad Street, Medical Office Building, Suite 212, Philadelphia, PA, 19140, USA.
    Chronic itch is a common skin manifestation in many connective tissue diseases. However, the cause of chronic itch in these diseases is still not fully understood. The complex, and in some cases incomplete understanding of, pathogenesis in each condition makes it difficult to target specific mediators of chronic itch. Read More

    Health-related quality of life in patients with psoriasis: a systematic review of the European literature.
    Qual Life Res 2016 Nov 3;25(11):2739-2754. Epub 2016 Jun 3.
    Outcomes'10, Castellón, Spain.
    Purpose: To summarize the data published over the last 5 years in the European Union related to the health-related quality of life (HRQoL) of patients with psoriasis and its conditioning factors.

    Methods: International electronic databases and gray literature were searched to identify studies conducted on patient-reported outcomes in patients with psoriasis, published in Europe between January 1, 2009 and December 31, 2013. Bibliographic references were hand-searched. Read More

    Phase I Study of Lenalidomide and Sorafenib in Patients With Advanced Hepatocellular Carcinoma.
    Oncologist 2016 Jun 2;21(6):664-5. Epub 2016 Jun 2.
    University of Washington School of Medicine, Seattle, Washington, USA.
    Lessons Learned: Combination therapies in patients with hepatocellular carcinoma can be associated with overlapping toxicity and are therefore poorly tolerated.Using sorafenib at the maximum tolerated dose can lead to a higher incidence of toxicities. Consequently, combination studies might evaluate sorafenib at alternative schedules or doses to improve tolerance, recognizing this could affect sorafenib efficacy. Read More

    Dupilumab, A Monoclonal Antibody for Atopic Dermatitis: A Review of Current Literature.
    Skin Therapy Lett 2016 Mar;21(2):1-5
    K. Papp Clinical Research, Waterloo, ON, Canada; Probity Medical Research, Waterloo, ON Canada.
    Atopic dermatitis results when aberrant barrier function and immune activation occur within the skin. Standard therapies for atopic dermatitis have fallen short, prompting efforts to discover novel therapeutics for this disease. Of these, dupilumab, a fully human monoclonal antibody that inhibits the actions of both IL-4 and IL-13, has shown the greatest promise. Read More

    Chronic Pruritus in the Absence of Skin Disease: Pathophysiology, Diagnosis and Treatment.
    Am J Clin Dermatol 2016 Aug;17(4):337-48
    Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Von-Esmarch-Str. 58, 48149, Münster, Germany.
    Chronic pruritus arises not only from dermatoses, but also, in up to half of cases, from extracutaneous origins. A multitude of systemic, neurological, psychiatric, and somatoform conditions are associated with pruritus in the absence of skin disease. Moreover, pruritus is a frequently observed side effect of many drugs. Read More

    Addressing treatment challenges in atopic dermatitis with novel topical therapies.
    J Dermatolog Treat 2016 Nov 11;27(6):568-576. Epub 2016 May 11.
    c Department of Dermatology and Itch Center, Lewis Katz School of Medicine , Temple University , Philadelphia , PA , USA.
    Atopic dermatitis (AD), a chronic inflammatory skin disease affecting children and adults, presents as mild-to-moderate disease in the majority of patients. Pruritus, one of the key diagnostic criteria for AD, is associated with reduced quality of life and disease aggravation. Current treatments include emollients and topical pharmaceutical agents. Read More

    Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor.
    Acta Dermatovenerol Croat 2016 Apr;24(1):70-2
    Daška Štulhofer Buzina, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;
    Dear Editor, Inhibition of the epidermal growth factor receptor (EGFR) is a new strategy in treatment of a variety of solid tumors, such as colorectal carcinoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and pancreatic cancer (1). Cetuximab is a chimeric human-murine monoclonal antibody against EGFR. Cutaneous side effects are the most common adverse reactions occurring during epidermal growth factor receptor inhibitors (EGFRI) therapy. Read More

    Systemic and spinal administration of FAAH, MAGL inhibitors and dual FAAH/MAGL inhibitors produce antipruritic effect in mice.
    Arch Dermatol Res 2016 Jul 28;308(5):335-45. Epub 2016 Apr 28.
    Department of Pharmacology, Drug Discovery and Research Center, Gulhane Academy of Medicine, Etlik, 06018, Ankara, Turkey.
    The increase of endocannabinoid tonus by inhibiting fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL) represents a promising therapeutic approach in a variety of disease to overcome serious central side effects of exocannabinoids. Recent studies reported that systemic administration of FAAH and MAGL inhibitors produce antipruritic action. Dual FAAH/MAGL inhibitors have also been described to get enhanced endocannabinoid therapeutic effect. Read More

    Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial.
    JAMA 2016 Apr;315(16):1715-25
    Chest Disease Department, University Hospital of Strasbourg, Strasbourg University, France.
    Importance: The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a potential novel treatment option for HDM allergy-related asthma.

    Objectives: To evaluate the efficacy and adverse events of the HDM SLIT tablet vs placebo for asthma exacerbations during an inhaled corticosteroid (ICS) reduction period.

    Design, Settings, And Participants: Double-blind, randomized, placebo-controlled trial conducted between August 2011 and April 2013 in 109 European trial sites. Read More

    Crisaborole Topical Ointment, 2%: A Nonsteroidal, Topical, Anti-Inflammatory Phosphodiesterase 4 Inhibitor in Clinical Development for the Treatment of Atopic Dermatitis.
    J Drugs Dermatol 2016 Apr;15(4):390-6
    Crisaborole topical ointment, 2% (formerly known as AN2728) is a benzoxaborole, nonsteroidal, topical, anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor investigational compound that recently completed phase 3 studies for the treatment of mild to moderate atopic dermatitis (AD). The unique configuration of boron within the crisaborole molecule enables selective targeting and inhibition of PDE4, an enzyme that converts the intracellular second messenger 3'5'-cyclic adenosine monophosphate (cAMP) into the active metabolite adenosine monophosphate (AMP). By inhibiting PDE4 and thus increasing levels of cAMP, crisaborole controls inflammation. Read More

    Therapies to improve the cosmetic symptoms of atopic dermatitis.
    Cutis 2016 Mar;97(3):183-6
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease. The cosmetic symptoms of AD can have a serious impact on a patient's quality of life. Although there currently is no cure for AD, treatment is aimed at relieving its symptoms and preventing acute exacerbations as well as improving cosmetic appearance to enhance quality of life. Read More

    ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients.
    J Eur Acad Dermatol Venereol 2016 May 23;30(5):729-47. Epub 2016 Mar 23.
    Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.
    Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease of children and adults. The diagnosis is made using evaluated clinical criteria. Disease activity is best measured with a composite score assessing both objective signs and subjective symptoms, such as SCORAD. Read More

    Pharmacological interventions for generalised itching (not caused by systemic disease or skin lesions) in pregnancy.
    Cochrane Database Syst Rev 2016 Feb 19;2:CD011351. Epub 2016 Feb 19.
    Cochrane Thailand, Khon Kaen University, 123 Mittapharp Road, Amphur Mueng, Khon Kaen, Thailand, 40002.
    Background: Generalised itching is one of the most common dermatological symptoms in pregnant women. Having itchy skin during pregnancy may be very frustrating and can lead to poor sleep, exhaustion and impaired quality of life. There is a need for a systematic review to evaluate the effectiveness and safety of pharmacological interventions for treating itching in pregnancy. Read More

    The Role of Naftifine HCl 2% Gel and Cream in Treating Moccasin Tinea Pedis.
    J Drugs Dermatol 2016 Feb;15(2 Suppl):s56-9
    In recent years, new topical antifungals have emerged for the treatment and management of tinea pedis, but all have been investigated and approved for the treatment of interdigital tinea pedis. Moccasin tinea pedis has not been recognized by governing bodies as a definable and treatable disease entity separate from interdigital tinea pedis at this time. Thus, creating randomized, controlled clinical trials to investigate moccasin tinea pedis is a challenge without an agreed upon definition of the disease state, treatment regimen, and treatment course. Read More

    Predictors of malignancy development in patients with chronic pruritus.
    J Dermatol Sci 2016 May 28;82(2):123-8. Epub 2016 Jan 28.
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
    Background: Patients with pruritus have been shown to have an increased incidence of certain subtypes of malignancy.

    Objective: To assess predictors of malignancy in patients with chronic pruritus without prior dermatologic diagnoses.

    Methods: Case-control study of 398 patients with chronic pruritus who developed a malignancy were compared with 8346 patients with chronic pruritus who did not develop a malignancy. Read More

    Panoptic clinical review of the current and future treatment of relapsed/refractory T-cell lymphomas: Cutaneous T-cell lymphomas.
    Crit Rev Oncol Hematol 2016 Mar 2;99:228-40. Epub 2016 Jan 2.
    Department of Experimental, Diagnostic, and Specialty Medicine, Bologna University School of Medicine, Via Massarenti 8, 40138 Bologna, Italy; Unit of Hematopathology, European Institute of Oncology, Via Ripamonti 435, Milan 20141, Italy.
    Primary cutaneous T-cell lymphomas (CTCLs), such as mycosis fungoides and Sézary syndrome, are a rare group of non-Hodgkin lymphomas, usually treated using a multimodal approach. Unfortunately, many patients go on to develop relapsed/refractory disease. Systemic treatment for relapsed/refractory CTCL has historically relied on chemotherapies and interferons, and while active, responses are often short-lived. Read More

    Target-oriented therapy: Emerging drugs for atopic dermatitis.
    Expert Opin Emerg Drugs 2016 15;21(1):81-9. Epub 2016 Feb 15.
    a Department of Dermatology and Allergy , Technical University of Munich , Munich , Germany.
    Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a life-time prevalence of 10 - 20% in western countries. Patients suffer from stigmatizing eczematous skin lesions, persisting itch and sleep disorders. Starting usually in early childhood the course of AD is heterogeneous. Read More

    Cell transplants to treat the "disease" of neuropathic pain and itch.
    Pain 2016 Feb;157 Suppl 1:S42-7
    Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
    Among many mechanisms implicated in the development of neuropathic pain after nerve damage is a profound dysfunction of GABAergic inhibitory controls, manifested by ongoing pain, mechanical hypersensitivity, and thermal hyperalgesia. In some respects, neuropathic pain can be considered a "disease" of the nervous system, with features in common with trauma-induced seizures. Indeed, first-line management involves anticonvulsant therapy. Read More

    Patient burden of moderate to severe atopic dermatitis (AD): Insights from a phase 2b clinical trial of dupilumab in adults.
    J Am Acad Dermatol 2016 Mar 14;74(3):491-8. Epub 2016 Jan 14.
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York.
    Background: The adult burden of atopic dermatitis (AD) is poorly characterized.

    Objective: We sought to characterize AD burden in adults with moderate to severe disease from the patient's perspective.

    Methods: Patient-reported outcomes collected at screening in a phase 2b clinical trial of dupilumab included pruritus numeric rating scale, 5-Dimension Pruritus Scale, subjective components of SCORing AD, Patient-Oriented Eczema Measure, Hospital Anxiety and Depression Scale, Dermatology Life Quality Index, and 5-Dimension EuroQol. Read More

    Ocular and cutaneous manifestation of leptospirosis acquired in Albania: A retrospective analysis with implications for travel medicine.
    Travel Med Infect Dis 2016 Mar-Apr;14(2):143-7. Epub 2015 Dec 18.
    Department of Infectious Diseases, University Hospital Center, Tirane, Albania.
    Unlabelled: Albania is an attractive tourism destination with an increasing volume of travel. As a Mediterranean country some tropical infectious diseases are present in certain areas of Albania, including leptospirosis, which is a zoonotic infectious disease prevalent around the world. The goal of this retrospective study is to describe the ocular and cutaneous manifestations of leptospirosis in Albanian patients and raise awareness to travelers travelling in and out of the country. Read More

    Advances in therapeutic strategies for the treatment of pruritus.
    Expert Opin Pharmacother 2016 23;17(5):671-87. Epub 2015 Dec 23.
    a Department of Dermatology & Temple Itch Center , Temple University School of Medicine , Philadelphia , PA , USA.
    Introduction: Chronic pruritus is a common symptom that arises from both dermatologic and non-dermatologic conditions including chronic kidney disease, cholestasis, lymphoma and neuropathy. Over the past decade, research has elucidated many of the receptors, neuropeptides and cytokines involved in itch sensation and transmission. In addition, the first biomarker for cholestatic itch has been discovered. Read More

    Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
    Sci Rep 2015 Nov 25;5:16768. Epub 2015 Nov 25.
    Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and the Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215021, China.
    The contributions of gasotransmitters to itch sensation are largely unknown. In this study, we aimed to investigate the roles of hydrogen sulfide (H2S), a ubiquitous gasotransmitter, in itch signaling. We found that intradermal injection of H2S donors NaHS or Na2S, but not GYY4137 (a slow-releasing H2S donor), dose-dependently induced scratching behavior in a μ-opioid receptor-dependent and histamine-independent manner in mice. Read More

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