4,028 results match your criteria Pruritic Urticarial Papules and Plaques of Pregnancy


Human polyomavirus 7 (HPyV7)-associated dermatoses: novel molecular mechanism driven by viral activation of 4E-BP1 and MEK-ERK-cJun.

Int J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, University of Texas Medical School, Houston, TX, USA.

A number of pruritic skin conditions arising in immunocompromised patients are associated with viral infection. Recently, human polyomavirus 7 (HPyV7) has been implicated in the pathogenesis of eruptive pruritic parakeratotic and dyskeratotic dermatoses with distinct "peacock plumage" histology. While expression of HPyV7 viral protein, namely small tumor (sT) antigen, is prominent within lesional tissue, the functional role of HPyV7 in cutaneous pathobiology is not yet known. Read More

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December 2018
1 Read

Dermpath & Clinic: Pruritic erythematous lesions on the trunk and legs.

Eur J Dermatol 2018 Oct;28(5):723-724

Dermatology Department, Edouard Herriot Hospital, Lyon, France.

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October 2018

Schnitzler's syndrome: A female elderly case presenting intractable non-pruritic febrile urticarial rush.

Asian Pac J Allergy Immunol 2018 Dec 9. Epub 2018 Dec 9.

Graduate School of Medical Sciences, Department of Dermatology, Kyushu University, Fukuoka, Japan.

Schnitzler's syndrome is an acquired autoinflammatory disease characterized by chronic urticarial rash and monoclonal gammopathy (predominantly IgM type). A 75-year-old Japanese woman complained of high fever and non-pruritic urticarial rash appearing almost every day for 3 years. Her abnormal laboratory data included leukocytosis and neutrophilia with elevated erythrocyte sedimentation rate and C-reactive protein level. Read More

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December 2018

Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease.

Authors:
Tanya M Laidlaw

World J Otorhinolaryngol Head Neck Surg 2018 Sep 5;4(3):162-168. Epub 2018 Sep 5.

Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, USA.

It is well-established that following ingestion of aspirin or any other inhibitor of cyclooxygenase-1, patients with Samter's disease, or aspirin-exacerbated respiratory disease (AERD) develop the sudden onset of worsening respiratory clinical symptoms, which usually involves nasal congestion, rhinorrhea, wheezing and bronchospasm. Gastrointestinal distress, nausea, a pruritic rash and angioedema can also occasionally develop. However, the underlying pathologic mechanism that drives these clinical reactions remains elusive. Read More

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September 2018
4 Reads

Alternative Treatments for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease in which management with topical anti-inflammatory agents during exacerbations remains the mainstay of treatment. With no cure in sight, a significant proportion of patients elect to incorporate complementary and alternative medicine (CAM) as an adjunct to conventional treatment. Many clinicians find it difficult to provide recommendations as the field covers an extensive number of very disparate therapies, with limited quality evidence to indicate efficacy. Read More

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December 2018
2 Reads

Pigmented pruritic macules in the genital area.

Cutis 2018 Oct;102(4):E21-E22

Division of Dermatology, Ohio State University Department of Internal Medicine, Columbus, Ohio, USA.

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October 2018

Acquired perforating dermatosis in a skin graft.

Cutis 2018 Oct;102(4):274;276;278

Department of Dermatology, Howard University Hospital, Washington, DC, USA.

Acquired perforating dermatosis (APD) is characterized by pruritic craterlike lesions with a predilection for patients affected by chronic kidney disease or diabetes mellitus (DM). We present a case of a 57-year-old black woman admitted for chest pain and dyspnea who was found to have 2 teardrop-shaped yellow-white-chalky plaques consistent with APD that developed at the site of a preexisting split-thickness skin graft (STSG). We also review the literature on APD. Read More

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October 2018
2 Reads

Subacute cutaneous lupus erythematosus induced by nivolumab: two case reports and a literature review.

Melanoma Res 2018 Nov 26. Epub 2018 Nov 26.

Departments of Dermatology.

Nivolumab is widely used to treat several late-stage malignancies such as melanoma and non-small-cell lung cancer by inhibiting the interaction between the programmed cell death protein-1 and its ligand. By stimulating an antitumor immune response, it also leads to immune adverse events. Here. Read More

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November 2018
1 Read

Aluminum granuloma in a child secondary to DTaP-IPV vaccination: A case report.

Pediatr Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, Oregon Health & Science University, Portland, Oregon.

Reports detailing the acute formation of aluminum granulomas, which can cause persistent, intensely pruritic nodules secondary to the administration of aluminum-containing vaccines, are infrequently described in medical literature. To our knowledge, this is the first report describing the development of an aluminum granuloma causing a persistent, pruritic nodule at the injection site following the administration of the DTaP-IPV vaccine. We present the case of a 6-year-old girl who developed a severely pruritic subcutaneous nodule on her anterior right thigh at the injection site three weeks after the administration of the aluminum-containing DTaP-IPV (Kinrix) vaccine. Read More

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November 2018
5 Reads

Pruritic Rash on the Hands and Feet.

Am Fam Physician 2018 Dec;98(11):685-686

St. Luke's Family Medicine Residency/Sacred Heart Campus, Allentown, PA, USA.

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December 2018
1 Read

Lokivetmab therapy for pruritus in a dog with cutaneous mastocytosis.

Vet Dermatol 2018 Nov 26. Epub 2018 Nov 26.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA, 30602, USA.

Background: Cutaneous mastocytosis (CM) is a rare disease of dogs characterized by rash, pruritus and proliferation of mast cells in the skin. Oral H1 antihistamines are recommended as the treatment to control pruritus.

Hypothesis/objective: To describe the effective treatment of pruritus associated with CM with lokivetmab in one dog. Read More

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November 2018
7 Reads

Diagnosis and Management of Atopic Dermatitis: A Review.

Adv Skin Wound Care 2018 Dec;31(12):538-550

Khalad Maliyar, BA • Medical Student • Faculty of Medicine • University of Toronto • Toronto, Ontario, Canada Cathryn Sibbald, MD, BScPhm, ACPR, FRCPC • Pediatric Dermatology Fellow • Children's Hospital of Philadelphia • Philadelphia, Pennsylvania Elena Pope, MD, MSc, FRCPC • Associate Professor • Department of Pediatrics • University of Toronto • Division Head of Pediatric Dermatology Medicine and Project Investigator • Hospital for Sick Children • Toronto, Ontario, Canada R. Gary Sibbald, DSc (Hons), MD, MEd, BSc, FRCPC (Med Derm), ABIM, FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course and Masters of Science in Community Health (Prevention and Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Past President • World Union of Wound Healing Societies • Editor-in-Chief • Advances in Skin and Wound Care • Philadelphia, Pennsylvania.

General Purpose: The purpose of this learning activity is to provide information about the diagnosis and management of atopic dermatitis (AD).

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After completing this continuing education activity, you should be able to:1. Read More

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December 2018
6 Reads

Pruritic Linear Eruption in a 53-Year-Old Woman: Answer.

Am J Dermatopathol 2018 Dec;40(12):935-936

Valley Dermatopathology, Sewickley, PA.

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December 2018

Three-dimensional optical clearing and imaging of pruritic atopic dermatitis and psoriasis skin reveals downregulation of epidermal innervation.

J Invest Dermatol 2018 Nov 21. Epub 2018 Nov 21.

National Skin Centre, 1 Mandalay Road Singapore 308205; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921. Electronic address:

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November 2018
1 Read

Pirfenidone-induced photosensitivity confirmed by pathological phototest.

Photodiagnosis Photodyn Ther 2018 Nov 20. Epub 2018 Nov 20.

Dermatology Department, University General Hospital of Valencia, Valencia, Spain.

Background: Idiopathic pulmonary fibrosis (IPF) is an idiopathic interstitial progressive fibrotic lung disease and the most lethal of all interstitial lung diseases. Pirfenidone is a novel antifibrotic and anti-inflammatory agent which reduces decline in lung function and prolonges progression-free survival. It has a favourable benefit-risk profile and is generally well tolerated. Read More

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November 2018
2 Reads

Going Viral 2019: Zika, Chikungunya, and Dengue.

Dermatol Clin 2019 Jan;37(1):95-105

Department of Dermatology, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Mitras Centro, Avenida Gonzalitos y Madero S/N, Monterrey 64460, Mexico.

Chikungunya and Zika virus infections are emerging diseases in the Americas, and dengue continues to be the most prevalent arthropod-borne virus in the world. These arbovirus diseases may spread by endemic transmission or as travel-related infections and have rapidly expanded their geographic distribution secondary to vector spread. All 3 share a similar clinical picture that includes a maculopapular rash. Read More

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January 2019
12 Reads

Myiasis incidences reported in and around central province of Sri Lanka.

Int J Dermatol 2018 Nov 21. Epub 2018 Nov 21.

Faculty of Medicine, Department of Surgery, University of Peradeniya, Kandy, Sri Lanka.

Background: Myiasis, or the invasion of living tissues of humans and other mammals by dipterous larvae, is considered the world's fourth most common travel-associated skin disease after cutaneous larval migrants, pyodermas, and pruritic arthropod-reactive dermatitis.

Method: The present study recorded the cause, anatomical position, and severity of the wounds of myiasis patients admitted to 11 hospitals located in the central region of Sri Lanka from February 2016 to July 2017.

Results: Altogether, 28 myiasis incidences were noted within the study period. Read More

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November 2018
6 Reads

The role of the Histamine H receptor in atopic dermatitis and psoriasis.

Br J Pharmacol 2018 Nov 21. Epub 2018 Nov 21.

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

Atopic dermatitis (AD) and psoriasis are common skin diseases with a high negative impact on patients´ quality of life. Both diseases are mediated by a pro-inflammatory infiltrate consisting of various cell types like T cells, antigen presenting cells and granulocytes and display disturbed keratinocyte differentiation. Given the fact that histamine levels are also highly elevated in inflamed skin, it is likely that histamine plays a relevant role in disease pathology. Read More

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November 2018
2 Reads

Clinical-pathological and immunological biomarkers in dogs with atopic dermatitis.

Vet Immunol Immunopathol 2018 Nov 23;205:58-64. Epub 2018 Oct 23.

Laboratório de Biologia das Interações Celulares, Departamento de Morfologia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, São Luiz, CEP: 31270-901, Belo Horizonte, Minas Gerais, Brazil; Grupo Integrado de Pesquisas em Biomarcadores, Instituto de Pesquisa René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima, 1715, Barro Preto, CEP: 30190-002, Belo Horizonte, Minas Gerais, Brazil; Instituto de Ciências Biológicas e da Saúde, Centro Universitário de Belo Horizonte, Avenida Professor Mário Werneck, 1685, Buritis, CEP: 30575-180, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Canine atopic dermatitis (CAD) is a chronic, pruritic, genetic, and inflammatory disease. Its pathogenesis is very complex and involves skin barrier defects and immune system dysfunction. This study aimed to investigate hematological, biochemical, clinical, and immunological parameters to contribute to the identification of biomarkers applied to CAD. Read More

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November 2018
2 Reads

Use of antipsychotic drugs in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):765-773. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Antipsychotic drugs can be beneficial in dermatology because of their both central nervous system and peripheral effects. All antipsychotic drugs have a central postsynaptic dopamine D2 receptor blocking effect, which underlies their antipsychotic action. The antipsychotic drugs have varying degrees of histamine H1-receptor, cholinergic muscarinic receptor, and α1-adrenergic receptor blocking effects, which can affect cutaneous perception and the autonomic reactivity of the skin and can be potentially beneficial in the management of certain histamine or sympathetically mediated dermatologic manifestations (eg, urticaria, pruritus, hyperhidrosis). Read More

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August 2018
9 Reads

Genomes of trombidid mites reveal novel predicted allergens and laterally transferred genes associated with secondary metabolism.

Gigascience 2018 Dec 1;7(12). Epub 2018 Dec 1.

Institute of Infection & Global Health, University of Liverpool, L3 5RF, United Kingdom.

Background: Trombidid mites have a unique life cycle in which only the larval stage is ectoparasitic. In the superfamily Trombiculoidea ("chiggers"), the larvae feed preferentially on vertebrates, including humans. Species in the genus Leptotrombidium are vectors of a potentially fatal bacterial infection, scrub typhus, that affects 1 million people annually. Read More

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December 2018
3 Reads

Use of maropitant for the control of pruritus in non-flea, non-food-induced feline hypersensitivity dermatitis: an open-label uncontrolled pilot study.

J Feline Med Surg 2018 Nov 14:1098612X18811372. Epub 2018 Nov 14.

3 University of Liège Veterinary Faculty, Small Animal Internal Medicine Service - Dermatology, Liège, Belgium.

Objectives: Non-flea, non-food-induced hypersensitivity dermatitis (NFNFIHD) is a common inflammatory and pruritic skin disease in cats. When avoidance and conventional systemic immunosuppressive treatments fail to control the clinical signs, there are limited treatment options. The aim of this study was to evaluate the efficacy and tolerability of maropitant in feline NFNFIHD. Read More

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November 2018
6 Reads

Novel drugs for the treatment of chronic pruritus.

Expert Opin Investig Drugs 2018 Dec 19;27(12):981-988. Epub 2018 Nov 19.

a Department of Dermatology and Center for Chronic Pruritus , University Hospital Münster , Münster , Germany.

Introduction: Chronic pruritus (CP) is a multidimensional condition severely affecting the quality of life of those affected. Although a multitude of topical and systemic agents are recommended for CP of different origins, the condition often remains refractory to treatment. However, a deeper understanding of the pathophysiology of CP is leading to the development of novel antipruritic drugs. Read More

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December 2018
11 Reads

Pruritic Blistering Eruption: Challenge.

Am J Dermatopathol 2018 Nov 5. Epub 2018 Nov 5.

Pathology, School of Medicine, University of Virginia, Charlottesville, VA.

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November 2018

A paediatric puzzle: pulsating, pruritic papules and plaques.

Clin Exp Dermatol 2018 Nov 12. Epub 2018 Nov 12.

Dermatology Department, St Mary's Hospital, Imperial College Healthcare Trust, Praed Street, Paddington, London W12 1NY, UK.

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November 2018

Histopathological diagnosis of persistent pruritic eruptions associated with adult-onset Still's disease.

Histopathology 2018 Nov 8. Epub 2018 Nov 8.

Department of Dermatology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Aims: Persistent pruritic eruptions (PPEs), presenting with dyskeratotic keratinocytes histologically, are common in patients with adult-onset Still's disease (AOSD). The lesions may be histologically similar to other entities that present with dyskeratosis.

Methods And Results: To investigate whether histopathological findings can be used to discriminate among PPEs and other entities presenting with dyskeratotic keratinocytes, cutaneous histopathological changes of PPEs associated with AOSD (n=26) were compared with those of systemic lupus erythematosus (SLE) (n=16), dermatomyositis (n=19), and drug eruption (n=16). Read More

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November 2018
1 Read

A case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with cytotoxic phenotype showing multiple ulcers on the entire body.

J Cutan Pathol 2018 Nov 8. Epub 2018 Nov 8.

Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan.

Primary cutaneous peripheral T-cell lymphoma, not otherwise specified (pcPTCL-NOS), is a rare, aggressive, fatal type of cutaneous T-cell lymphoma. The clinical presentation of pcPTCL-NOS is characterized by generalized plaques, nodules or tumors but ulcers are uncommon. We report an atypical case of pcPTCL-NOS with cytotoxic protein expression, presenting as multiple ulcers on the entire body. Read More

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November 2018
10 Reads

Eosinophilic polymorphic and pruritic eruption associated with radiotherapy: case report and overview of disease characteristics.

Clin Exp Dermatol 2018 Nov 8. Epub 2018 Nov 8.

Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Dermatology, Universitätsklinikum Erlangen, Erlangen, Germany.

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November 2018

Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horses.

Allergy 2018 Nov 7. Epub 2018 Nov 7.

RIA Immunology, Inselspital, University of Bern, Bern, Switzerland.

Background: Insect-bite hypersensitivity (IBH) in horses is a chronic allergic dermatitis caused by insect bites. Horses suffer from pruritic skin lesions, caused by type-I/type-IV allergic reactions accompanied by prominent eosinophil infiltration into the skin. Interleukin-5 (IL-5) is the key cytokine for eosinophils and we have previously shown that targeting IL-5 by vaccination reduces disease symptoms in horses. Read More

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November 2018
2 Reads

Generalized rash and pruritus in a 58-year-old woman.

Allergy Asthma Proc 2018 Nov;39(6):468-471

From the Section of Allergy and Immunology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Although allergists often evaluate rashes associated with allergic, IgE mediated etiologies, it is important to consider a wide range of differential diagnoses that includes inflammatory, infectious, and autoimmune etiologies. The case of a 58-year-old woman with a 1-year history of progressive pruritic rash that did not improve with topical creams and steroids is presented. The patient did not state any other symptoms, and a physical examination was notable for a widespread rash. Read More

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November 2018
2 Reads

Assessment of atopic dermatitis as a risk factor for chronic spontaneous urticaria in a pediatric population.

Allergy Asthma Proc 2018 Nov;39(6):445-448

From the Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.

Atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) represent two of the most common chronic inflammatory pruritic skin diseases. Any relationship between atopic skin disorders and CSU is controversial, mostly due to the paucity of relevant epidemiologic and pathogenetic data. To evaluate whether a history of AD in early childhood represents a risk factor for the subsequent occurrence of CSU in a pediatric population. Read More

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November 2018
4 Reads

Pruritic, scaly, serpiginous plaques in a 10-year-old boy.

Pediatr Dermatol 2018 Nov;35(6):838-840

Department of Dermatology, St. Joseph Mercy Hospital, Ann Arbor, Michigan, USA.

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November 2018
1 Read

Association Between Delusions of Infestation and Prescribed Narcotic and Stimulant Use.

J Psychiatr Pract 2018 Nov;24(6):428-431

ZHU: Keck School of Medicine, University of Southern California, Los Angeles, CA WERCHAN, ESCAMILLA: Department of Psychiatry, Dell Medical School at the University of Texas, Austin, TX SEBASTIAN: Ascension Texas Research Support Services, Austin, TX HOVINGA: Ascension Texas Research Support Services and The University of Texas at Austin College of Pharmacy, Austin, TX REICHENBERG: Department of Dermatology, Dell Medical School at the University of Texas, Austin, TX.

Objective: Patients diagnosed with delusions of infestation (DOI) at a psychodermatology clinic appeared to have a higher incidence of being prescribed narcotic or stimulant medications compared with the general dermatologic clinic population with chronic pruritic conditions. A retrospective study was conducted examining the correlation between patients with DOI and prescribed psychoactive medications.

Methods: Ninety-two patients with a diagnosis of DOI, seen at our University Psychodermatology Clinic, served as the study population. Read More

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November 2018

Autoimmune Progesterone Dermatitis Diagnosed by Lymphocyte Transformation Test and Progesterone Provocation Test.

Acta Dermatovenerol Croat 2018 Oct;26(3):276-277

Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology University Hospital Center Zagreb School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Autoimmune progesterone dermatitis (APD) is rare autoimmune response to endogenous progesterone or to earlier exposure to exogenous progesterone (1). Skin lesions typically occur due to increases in progesterone during the luteal phase of the menstrual cycle (2). A-31-year-old mother of two children presented to our Department with a 5-year history of pruritic and painful erythematosus macules, papules, and patches on her neck, pectoral region, and face, which appeared 2-3 days before the onset of menses and gradually resolved 7-10 days later (Figure 1). Read More

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October 2018
6 Reads

Two Cases of Dermatitis Herpetiformis Successfully Treated with Tetracycline and Niacinamide.

Acta Dermatovenerol Croat 2018 Oct;26(3):273-275

Baoqi Yang, MD, Department of Dermatology Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences 27397 Jingshi Road, Jinan, Shandong, 250022, China;

Dear Editor, Dermatitis herpetiformis (DH) is a chronic, polymorphic, pruritic autoimmune blistering skin disease characterized by subepidermal blisters, neutrophilic microabscesses, and granular IgA deposition within the dermal papillae. DH is classified as a cutaneous manifestation of coeliac disease, a type of gluten-sensitive enteropathy (1). The treatment of DH includes dapsone and a gluten-free diet (GFD). Read More

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October 2018
2 Reads

Dermatobia Hominis Infestation Misdiagnosed as Abscesses in a Traveler to Spain.

Acta Dermatovenerol Croat 2018 Oct;26(3):267-269

Carmen Rodriguez Cerdeira, MD, Dermatology Service, Meixoeiro Hospital, CHUVI, C/Meixoeiro S/N 36200, Vigo, Spain;

Dear Editor, A 29-year-old woman presented with abscesses on her buttock and leg attributed to flea bites inflicted 5 days earlier on return to Spain after 2 months in Guinea-Bissau. Ciprofloxacin was ineffective after 7 days, and she was referred for dermatologic evaluation. Examination revealed 4 round, indurated, erythematous-violet furunculoid lesions with a 1. Read More

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October 2018
4 Reads

Long-term Follow-up of a Case of Lymphomatoid Papulosis with a Benign Course.

Acta Dermatovenerol Croat 2018 Oct;26(3):264-266

Jaka Radoš, MD, University Hospital Centre Zagreb Department of Dermatology and Venereology School of Medicine University of Zagreb Šalata 4, 10000 Zagreb , Croatia;

Dear Editor,We present the case of a 40-year old male patient with lymphomatoid papulosis of a waxing and waning course on whom three biopsies were performed during a 14-year period with no change in histopathological or immunophenotypical characteristics. Lymphomatoid papulosis (LP) is a chronic, recurrent, self-healing papulonodular skin eruption with the histopathologic features of a cutaneous T-cell lymphoma but an often benign and indolent clinical course (1). It is designated as a primary, cutaneous, CD30+ lymphoproliferative disorder. Read More

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October 2018
12 Reads

Prolonged Treatment of Eosinophilic Erythema Annulare with Chloroquine.

Acta Dermatovenerol Croat 2018 Oct;26(3):262-263

Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology University Hospital Center Zagreb School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor,Eosinophilic annular erythema (EAE) is a rare figurate dermatitis of unknown etiology with prominent tissue eosinophilia. A 59-year-old male patient presented with a one-month history of itchy, polycyclic, annular, and partially serpiginous lesions involving the back, the gluteal region, and the extremities (Figure 1, a, b). There was no medical history of drug intake. Read More

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October 2018
11 Reads

[32-year-old female, pregnant and with pruritic rash : Preparation for the medical specialist examination: Part 4].

Authors:
Falk Ochsendorf

Hautarzt 2018 Nov;69(Suppl 2):91-95

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum, Theodor-Stern-Kai 7, 60590, Frankfurt a. M, Deutschland.

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November 2018

Dupilumab for off-label treatment of moderate to severe childhood atopic dermatitis.

Cutis 2018 Sep;102(3):201-204

Skin Cancer & Cosmetic Dermatology Center, Dalton, Georgia, USA.

Atopic dermatitis (AD) is a complex chronic pruritic skin disease in which helper T cell (TH2)-type cytokines IL-4 and IL-13 are key contributors in the inflammatory response. Debate still exists as to whether disease initiation is due to immune responses or barrier dysregulation. The disease course is divided into infantile, childhood, and adolescent/adult stages and exhibits an extensive clinical spectrum. Read More

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September 2018
3 Reads

Consensus Recommendations on Adjunctive Topical Management of Atopic Dermatitis.

J Drugs Dermatol 2018 Oct;17(10):1070-1076

Atopic dermatitis (AD) is well-recognized as a very common chronic and relapsing pruritic skin disorder affecting both children and adults worldwide. The adverse effects on the quality of life of affected individuals and their families is well-established. The pathophysiology of AD is complex, leading to interindividual variations in clinical presentation and severity. Read More

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October 2018
3 Reads

To scratch an itch: Establishing a mouse model to determine active brain areas involved in acute histaminergic itch.

IBRO Rep 2018 Dec 15;5:67-73. Epub 2018 Oct 15.

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, NC, USA.

Background: Strategies to efficiently control itch require a deep understanding of the underlying mechanisms. Several areas in the brain involved in itch and scratching responses have been postulated, but the central mechanisms that drive pruritic responses are still unknown. Histamine is recognized as a major mediator of itch in humans, and has been the most frequently used stimulus as an experimental pruritogen for brain imaging of itch. Read More

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December 2018
8 Reads

Effects of pruritogens and algogens on rostral ventromedial medullary ON and OFF cells.

J Neurophysiol 2018 Nov 27;120(5):2156-2163. Epub 2018 Jun 27.

Department of Neurobiology, Physiology and Behavior, University of California , Davis, California.

Rostroventromedial medulla (RVM) ON and OFF cells are thought to facilitate and inhibit spinal nociceptive transmission, respectively. However, it is unknown how ON and OFF cells respond to pruritic stimuli or how they contribute to descending modulation of spinal itch signaling. In pentobarbital sodium-anesthetized mice, single-unit recordings were made in RVM from ON and OFF cells identified by their respective increase or decrease in firing that occurred just before nocifensive hindlimb withdrawal elicited by paw pinch. Read More

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November 2018
6 Reads

SLE in a Male Patient Presented Initially as Rowell's Syndrome.

J Assoc Physicians India 2018 Jan;66(1):98-99

Professor, Department of Tropical Medicine, School of Tropical Medicine, Kolkata, West Bengal.

A 22 year old male Indian patient presented with high grade fever, multiple joint pain, low back pain, generalized body ache since 6 months and erythematous pruritic rashes and atypical annular target like lesions over face, arm, leg and back and ulcers on hard palate and buccal mucosa for 2 months. Laboratory investigations showed a speckled pattern anti-nuclear antibody with a titer >1:160 and positive SS-A, dsDNA auto-antibodies and Rheumatoid factor. Diagnosis of Rowell's syndrome was made based on clinical and laboratory finding and the patient was treated with oral prednisolone (50 mg/day), hydroxychloroquine (200 mg q12h) and pulse cyclophosphamide (700 mg) chemotherapy. Read More

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January 2018
5 Reads

Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of MrgprA3/TRPA1-mediated pathway.

J Ginseng Res 2018 Oct 18;42(4):470-475. Epub 2017 May 18.

College of Pharmacy, Gachon University, Incheon, Republic of Korea.

Background: It was previously found that Korean Red Ginseng water extract (KRGE) inhibits the histamine-induced itch signaling pathway in peripheral sensory neurons. Thus, in the present study, we investigated whether KRGE inhibited another distinctive itch pathway induced by chloroquine (CQ); a representative histamine-independent pathway mediated by MrgprA3 and TRPA1.

Methods: Intracellular calcium changes were measured by the calcium imaging technique in the HEK293T cells transfected with both and ("), and in primary culture of mouse dorsal root ganglia (DRGs). Read More

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October 2018
1 Read

Vitamin D Level and Supplementation in Pediatric Atopic Dermatitis: A Randomized Controlled Trial.

J Cutan Med Surg 2018 Oct 18:1203475418805744. Epub 2018 Oct 18.

1 Section of Dermatology, Division of Pediatric Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a pruritic eczematous rash. Evidence surrounding the role of serum vitamin D (VD) in modifying disease severity is inconsistent.

Objectives: To determine whether VD levels are correlated with AD severity and the effects of VD supplementation on disease modification. Read More

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October 2018
9 Reads

Acquired widespread lymphangiectasia mimicking immunobullous disease: A case report.

SAGE Open Med Case Rep 2018 9;6:2050313X18802137. Epub 2018 Oct 9.

Department of Dermatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.

A 76-year-old Caucasian woman presented with a 3-year history of a recurrent pruritic eruption on the hips, thighs, and under the breasts associated with intermittent lesions resembling vesicles and bullae that failed to respond to topical corticosteroids. She had a history of severe lichen sclerosis et atrophicus, leading to invasive squamous cell carcinoma of the vulva for which she underwent radical vulvectomy and bilateral inguino-femoral lymph node dissection. On physical examination, involving the inframammary breasts, abdomen, hips, and proximal thighs there were multiple erosions with hemorrhagic crust and multiple clustered translucent papules. Read More

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October 2018
2 Reads

[Allergic contact dermatitis caused by curcumin-containing chlorhexidine].

Ugeskr Laeger 2018 Oct;180(42)

Contact dermatitis in connection with skin disinfection with yellow-coloured curcumin containing chlorhexidine solution prior to surgery is very rare. However, this case report presents a 59-year-old patient, who developed pruritic erythematous papules, patches and vesicles over the areas, where curcumin-containing disinfectant was applied. The diagnosis was made by allergic patch test, and the patient was treated with a topical steroid. Read More

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October 2018
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