428 results match your criteria Prurigo Nodularis


Prurigo nodularis and pembrolizumab: A therapeutic challenge.

Eur J Cancer 2019 Feb 5;110:8-10. Epub 2019 Feb 5.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1016/j.ejca.2019.01.012DOI Listing
February 2019

[Unprecedented interest in prurigo nodularis].

Authors:
L Misery

Ann Dermatol Venereol 2019 Feb 26;146(2):89-91. Epub 2019 Jan 26.

Service de dermatologie et centre expert sur le prurit, CHU, 2, avenue Foch, 29200 Brest, France; Laboratoire sur les interactions épithéliums-neurones (LIEN-EA4685), université de Bretagne occidentale, 29200 Brest, France. Electronic address:

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http://dx.doi.org/10.1016/j.annder.2018.12.004DOI Listing
February 2019

Pemphigoid nodularis - rare presentation of bullous pemphigoid: A case report and literature review.

Exp Ther Med 2019 Feb 5;17(2):1132-1138. Epub 2018 Dec 5.

Department of Dermatology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.

Pemphigoid nodularis (PN) is a rare clinical variant of bullous pemphigoid characterized by the presence of nodular prurigo-like lesions and pemphigoid blisters. The diagnosis is confirmed by direct immunofluorescence (DIF)/ indirect immunofluorescence (IIF) and immunoserology tests. For some patients, with long mean duration of symptoms, the correct diagnosis of PN is delayed because the disease is not recognized. Read More

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http://dx.doi.org/10.3892/etm.2018.7057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327548PMC
February 2019
1 Read

Scabies presenting as cutaneous nodules or malar erythema: reports of patients with scabies surrepticius masquerading as prurigo nodularis or systemic lupus erythematosus.

Dermatol Online J 2018 Sep 15;24(9). Epub 2018 Sep 15.

School of Medicine, University of California San Diego, La Jolla, California.

Scabies surrepticius is a unifying term that represents non-classical presentations of scabies mite infestation. A patient with scabies surrepticius is described: a man with scabies masquerading as prurigo nodularis. The 91-year-old man had metastatic prostate cancer and presented with diffuse pruritic nodules. Read More

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September 2018
1 Read

Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1.

Authors:
Bo Xie Xin-Yu Li

J Dermatol 2018 Dec 27. Epub 2018 Dec 27.

Department of Pharmacology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Chronic itch with an itch-scratch vicious circle is a significant problem in a large amount of diseases. Some of these diseases, such as psoriasis, atopic dermatitis, prurigo nodularis, Sézary syndrome, uremic pruritus, diabetes and jaundice, are common. For a very long time, chronic itch has been a thorny problem with few effective treatments. Read More

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http://dx.doi.org/10.1111/1346-8138.14749DOI Listing
December 2018
8 Reads

The Antipruritic Effect of Phototherapy.

Authors:
Franz J Legat

Front Med (Lausanne) 2018 30;5:333. Epub 2018 Nov 30.

Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria.

Phototherapy is widely used to treat inflammatory skin diseases such as psoriasis and atopic dermatitis. Repeated suberythemogenic doses of UV-light reduce inflammation in these diseases and ultimately may lead to a complete disappearance of cutaneous symptoms for weeks or months. Chronic pruritus is an important and highly distressing symptom of many of these inflammatory skin diseases. Read More

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http://dx.doi.org/10.3389/fmed.2018.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287194PMC
November 2018
1 Read

Clinical characteristics and genetic variation in atopic dermatitis patients with and without allergic contact dermatitis.

Eur J Dermatol 2018 Oct;28(5):637-643

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

In patients with atopic dermatitis (AD), the risk of contact sensitization may be higher as the disrupted skin barrier may increase the penetration of contact allergens. Therefore, it is necessary to screen for concurrent allergic contact dermatitis (ACD) in AD patients. To identify the clinical characteristics and genetic variation in AD patients with concurrent ACD. Read More

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http://dx.doi.org/10.1684/ejd.2018.3422DOI Listing
October 2018
2 Reads

Allergic contact dermatitis caused by chloramphenicol with prurigo nodularis-like spreading.

Contact Dermatitis 2018 Nov 28. Epub 2018 Nov 28.

Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1111/cod.13187DOI Listing
November 2018
2 Reads

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, University of California, Irvine.

Importance: Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety of systemic pathways, including the immune system, in low doses of 1.5 to 4. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.4093DOI Listing
November 2018
17 Reads

Use of antiepileptic mood stabilizers in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):756-764. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Several antiepileptic drugs (AEDs) are approved by the US Food and Drug Administration for the treatment of bipolar disorder (valproic acid, divalproex, lamotrigine, carbamazepine) and some cutaneous neuropathic pain syndromes (carbamazepine, gabapentin, pregabalin). The AEDs may be effective in the management of (1) chronic pruritus, including pruritus due systemic disease, including uremia, neuropathic pain, neuropathic pruritus, and complex cutaneous sensory syndromes, especially where central nervous system (CNS) sensitization plays a role; (2) management of emotional dysregulation and the resultant repetitive self-excoriation or other cutaneous self-injury in patients who repetitively stimulate or manipulate their integument to regulate emotions (prurigo nodularis, lichen simplex chronicus, skin picking disorder, trichotillomania); (3) management of dermatologic clinical manifestations associated with autonomic nervous system activation (hyperhidrosis, urticaria, flushing; these often occur in conjunction with psychiatric disorders with prominent autonomic activation and dysregulation, eg, social anxiety disorder, posttraumatic stress disorder); and (4) when certain anticonvulsants have a direct therapeutic effect (eg, in psoriasis); currently the use of AEDs for such cases is largely experimental. Gabapentin (dosage range 300-3600 mg daily) is the most widely studied AED mood stabilizer in dermatology and is especially effective in situations where CNS sensitization is a mediating factor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183017
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http://dx.doi.org/10.1016/j.clindermatol.2018.08.005DOI Listing
August 2018
16 Reads

Dupilumab Treatment for Generalized Prurigo Nodularis.

JAMA Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, University of California, San Francisco, San Francisco.

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.3912DOI Listing
November 2018
5 Reads

Reduced Itch Associated With Dupilumab Treatment In 4 Patients With Prurigo Nodularis.

JAMA Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1001/jamadermatol.2018.3906DOI Listing
November 2018

[Kaposi sarcoma in a patient with ANCA vasculitis requiring hemodialysis].

Rev Med Interne 2018 Dec 10;39(12):942-945. Epub 2018 Oct 10.

Service de Néphrologie, de dialyse et de transplantation rénale, CHU La Rabta, Tunis, Tunisie; Faculté de Médecine de Tunis, Université Tunis El Manar, Tunis, Tunisie.

Introduction: Iatrogenic Kaposi's sarcoma is widely reported after transplantation. Less commonly, it occurs in patients receiving immunosuppressive therapy for ANCA associated vasculitis. We report here the rare association of Kaposi's sarcoma, prurigo nodularis and ANCA associated vasculitis in a hemodialysis patient. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02488663183066
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http://dx.doi.org/10.1016/j.revmed.2018.08.001DOI Listing
December 2018
10 Reads

A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics.

J Am Acad Dermatol 2019 Feb 1;80(2):390-401. Epub 2018 Oct 1.

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois. Electronic address:

Background: Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms.

Objective: To determine the prevalences of AD characteristics and differences by region and age.

Methods: A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii that analyzed the proportion of AD characteristics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183264
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http://dx.doi.org/10.1016/j.jaad.2018.09.035DOI Listing
February 2019
4 Reads

A systematic review of evidence-based treatments for prurigo nodularis.

J Am Acad Dermatol 2019 Mar 25;80(3):756-764. Epub 2018 Sep 25.

Department of Dermatology, George Washington Medical Faculty Associates, Washington, DC; Department of Dermatology, George Washington School of Medicine and Health Sciences, George Washington University, Washington, DC. Electronic address:

Prurigo nodularis is a chronic dermatologic condition involving the development of multiple cutaneous nodules in the setting of intractable pruritus. Given emerging treatment options for this difficult-to-treat condition, a current review of therapeutics is needed. A systematic review was performed for clinical studies investigating prurigo nodularis treatment published from 1990 to present including ≥5 subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183262
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http://dx.doi.org/10.1016/j.jaad.2018.09.020DOI Listing
March 2019
26 Reads

The Prevalence of Psychiatric Comorbidity in Patients with Prurigo Nodularis.

Indian Dermatol Online J 2018 Sep-Oct;9(5):318-321

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Prurigo nodularis (PN) is a chronic, recalcitrant itchy dermatosis. It is supposed to be associated with psychological factors, but research in this area is scarce.

Objectives: To study the prevalence and determinants of psychiatric morbidity, and the phenomenology of itch in PN. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_324_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137669PMC
September 2018
12 Reads

Prurigo Nodularis after Radiotherapy: An Isoradiotopic Response?

Case Rep Dermatol Med 2018 13;2018:9186745. Epub 2018 Aug 13.

Department of Plastic Surgery, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark.

Prurigo nodularis is a rare and chronic skin disorder with multiple, pruritic, and firm nodules. The exact pathophysiology is still unknown. Skin disorders appearing at sites of radiation can be defined as isoradiotopic. Read More

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http://dx.doi.org/10.1155/2018/9186745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139234PMC

Gorlin Syndrome Presentation and the Importance of Differential Diagnosis of Skin Cancer: A Case Report.

J Pharm Pharm Sci 2018 ;21(1s):222s-224s

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.

In a busy community practice, clinical skin findings can often be misinterpreted. Skin cancers can sometimes mimic rashes like psoriasis, eczema or prurigo nodularis in both appearance and symptoms. Gorlin syndrome is one such genetic syndrome, characterized by the eruption of multiple and early onset basal cell carcinomas (BCCs), which can be mistaken for a rash. Read More

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http://dx.doi.org/10.18433/jpps30150DOI Listing
January 2018
3 Reads

Xerosis cutis and associated co-factors in women with prurigo nodularis.

An Bras Dermatol 2018 Sep-Oct;93(5):671-679

Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Background: Current data regarding the associated factors of prurigo nodularis are still uncertain, except for atopic predisposition.

Objectives: The purposes of this study were to (1) determine the frequencies of xerosis and other accompanying diseases of female patients with prurigo nodularis; (2) compare the demographic, clinical and accompanying disease characteristics by grouping these patients according to whether they have associated xerosis (who were subsequently subgrouped as atopic or non-atopic) or not.

Methods: In this retrospective descriptive study, 80 females with PN were categorized according to the accompanying diseases (dermatological, systemic, neurological, psychogenic, mixed, or undetermined origin). Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106662PMC
October 2018
6 Reads

Inflammatory dermatoses in human immunodeficiency virus.

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):113-120

Department of Dermatology and S.T.D., Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

Various inflammatory dermatoses have been described in association with human immunodeficiency virus (HIV) infection. These either present in the usual way or in varied atypical presentations. This article gives a brief review about the etiopathogenesis and clinical presentation of the common inflammatory dermatoses associated with HIV such as psoriasis, reactive arthritis, seborrheic dermatitis, eosinophilic folliculitis, pruritic papular eruption, photosensitivity disorders prurigo nodularis, atopic dermatitis, and ichthyosis. Read More

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http://www.ijstd.org/text.asp?2017/38/2/113/216986
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http://dx.doi.org/10.4103/ijstd.IJSTD_22_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085932PMC
August 2018
9 Reads

Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: Results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial.

J Am Acad Dermatol 2018 Sep;79(3):457-463.e5

Center for Chronic Pruritus, Department of Dermatology, University Hospital of Münster, Münster, Germany.

Background: Chronic pruritus is a multifactorial, challenging symptom of global relevance.

Objective: The European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) investigation aimed to analyze the severity and humanistic burden of chronic pruritus in patients suffering from inflammatory dermatoses across Europe.

Methods: Prospectively collected routine data on 552 patients (with atopic dermatitis, contact dermatitis, prurigo nodularis, psoriasis vulgaris, lichen planus, or mycosis fungoides [pruritus numeric rating scale score ≥3]) from 9 European centers (in Austria, France, Germany, Italy, Poland, Russia, Spain, Switzerland, and Turkey) were analyzed by univariate and multivariate variance analyses of various itch characteristics and quality of life (as measured by the Dermatology Life Quality Index and the ItchyQoL). Read More

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http://dx.doi.org/10.1016/j.jaad.2018.04.044DOI Listing
September 2018
5 Reads

Comprehending prurigo nodularis: Ay, there's the rub.

Authors:
Warren R Heymann

J Am Acad Dermatol 2018 10 6;79(4):636-637. Epub 2018 Aug 6.

Division of Dermatology, Cooper Medical School of Rowan University, Marlton, New Jersey. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.08.001DOI Listing
October 2018
5 Reads

Itching at night: A review on reducing nocturnal pruritus in children.

Pediatr Dermatol 2018 Sep 26;35(5):560-565. Epub 2018 Jun 26.

Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

The most common causes of chronic nocturnal itching in children are atopic dermatitis and psoriasis, with lichen simplex chronicus and prurigo nodularis contributing to lesser degrees. Despite the prevalence of nocturnal itching, its pathophysiology remains poorly understood. The most troubling consequence of itching at night is poor quality of sleep. Read More

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http://dx.doi.org/10.1111/pde.13562DOI Listing
September 2018
18 Reads

Immunomodulating Agents as Antipruritics.

Dermatol Clin 2018 Jul 16;36(3):325-334. Epub 2018 Apr 16.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Campus Box 8123, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA; Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA; Center for the Study of Itch, Washington University School of Medicine, St Louis, MO, USA. Electronic address:

Chronic pruritus, or itch lasting greater than 6 weeks, is an increasingly common and debilitating medical problem. Recent studies have unveiled previously unrecognized neuroimmune axes whereby inflammatory cytokines act directly on the nervous system to promote itch. Thus, the emergence of newer targeted biologic therapies has generated the possibility of novel treatment strategies for chronic itch disorders. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.014DOI Listing
July 2018
5 Reads

Prurigo Nodularis and Its Management.

Dermatol Clin 2018 Jul 20;36(3):189-197. Epub 2018 Mar 20.

Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Von- Esmarch-Strasse 58, Münster DE-48149, Germany.

Prurigo nodularis occurs with chronic pruritus and the presence of single to multiple symmetrically distributed, hyperkeratotic, and intensively itching nodules. Diverse dermatologic, systemic, neurologic, or psychiatric conditions can lead to prurigo nodularis. Structural analysis demonstrated a reduced intraepidermal nerve fiber density and increased dermal levels of nerve growth factor and neuropeptides such as substance P and calcitonin gene-related peptide. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.003DOI Listing
July 2018
15 Reads

Chronic Prurigo: An Unusual Presentation of Hodgkin Lymphoma.

Case Rep Dermatol 2018 May-Aug;10(2):122-126. Epub 2018 May 17.

Department of Dermatology, Geneva University Hospital, Geneva, Switzerland.

Background: Prurigo nodularis is a condition of unknown origin defined by papulonodular eruption and intense pruritus. Hodgkin lymphoma often presents nonspecific initial symptoms. An association between systemic malignancy and cutaneous manifestations has long been documented. Read More

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http://dx.doi.org/10.1159/000489161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006658PMC
May 2018
9 Reads

Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need.

J Eur Acad Dermatol Venereol 2018 Dec 1;32(12):2224-2229. Epub 2018 Jul 1.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Background: Prurigo nodularis (PN) is a chronic skin condition characterized by intensely pruritic, hyperkeratotic papulonodular lesions that dramatically impairs patients' quality of life. Management of the condition is challenging, and there is no approved therapy in the United States or in Europe.

Objective: The key aim of this survey was to examine current perceptions of PN diagnosis and management among members of the European Academy of Dermatology and Venereology (EADV). Read More

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http://dx.doi.org/10.1111/jdv.15107DOI Listing
December 2018
1 Read

Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders.

Am J Clin Hypn 2018 Jul;61(1):34-44

a University of South Florida , Tampa , FL, USA.

Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

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https://www.tandfonline.com/doi/full/10.1080/00029157.2017.1
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http://dx.doi.org/10.1080/00029157.2017.1419457DOI Listing
July 2018
44 Reads

Ethnic differences and comorbidities of 909 prurigo nodularis patients.

J Am Acad Dermatol 2018 Oct 4;79(4):714-719.e3. Epub 2018 May 4.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Electronic address:

Background: Prurigo nodularis (PN) is a poorly understood, understudied pruritic dermatosis that reduces quality of life.

Objective: To characterize the demographics and comorbidities associated with PN.

Methods: Cross-sectional study of patients 18 years and older who were seen at the Johns Hopkins Health System between December 6, 2012, and December 6, 2017. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.04.047DOI Listing
October 2018
7 Reads

Thalidomide for the treatment of chronic refractory prurigo nodularis.

Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore MD.

Prurigo nodularis (PN) is a highly pruritic skin condition that is caused by chronic scratching. It occurs in patients with chronic itch and is characterized by multiple hyperkeratotic papules and nodules. The pathogenesis of PN is unclear, but involves a complex interplay of numerous pathways including neurogenic and inflammatory factors. Read More

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March 2018
5 Reads

Cutaneous Adverse Reactions of Chemotherapy in Cancer Patients: A Clinicoepidemiological Study.

Indian J Dermatol 2018 Jan-Feb;63(1):41-46

Department of Dermatology, Venereology and Leprosy, S. P. Medical College, Bikaner, Rajasthan, India.

Background: The diagnosis of cutaneous adversities in the cancer patient is especially difficult, given the complexity of their illness and combination protocols used for the treatment. The present study was undertaken to know the spectrum of cutaneous adversities in patients undergoing chemotherapy and the drug(s) most commonly associated with it.

Materials And Methods: A total of 1000 patients with malignancies under chemotherapy in the oncology ward and outpatient department were screened in this observational study from January 2013 to February 2015. Read More

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http://dx.doi.org/10.4103/ijd.IJD_65_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838753PMC
March 2018
7 Reads

The use of biodegradable microneedle patches to increase penetration of topical steroid for prurigo nodularis.

Eur J Dermatol 2018 Feb;28(1):71-77

Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Background: The stratum corneum is an almost impermeable barrier. Recently, microneedles have been used to increase drug delivery passing the stratum corneum by incorporating the drug within the microneedle or by coating the surface of the microneedle with the drug.

Objective: This study was performed to investigate whether applying a biodegradable microneedle patch after topical steroid application increases penetration of the steroid in vitro, as well as treatment efficacy in patients with prurigo nodularis. Read More

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http://dx.doi.org/10.1684/ejd.2017.3164DOI Listing
February 2018
22 Reads

Rapid improvement of prurigo nodularis with cyclosporine treatment.

J Am Acad Dermatol 2018 Jun 10;78(6):1209-1211. Epub 2018 Feb 10.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.02.024DOI Listing
June 2018
7 Reads

Use of Isoquercetin in the Treatment of Prurigo Nodularis.

J Drugs Dermatol 2017 Nov;16(11):1156-1158

Atopic dermatitis and prurigo nodularis result from complex interactions between the skin, the immune system, and the external environment. The pruritus associated with these conditions greatly impacts patients' quality of life and lacks uniformly effective treatment. A 57-year-old patient presented with severe atopic dermatitis and subsequent prurigo nodularis refractory to numerous standard therapies. Read More

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November 2017
3 Reads

Chronic Prurigo of Nodular Type: A Review.

Acta Derm Venereol 2018 Feb;98(2):173-179

Center for Chronic Pruritus, Department of Dermatology, University Hospital Münster, Von- Esmarch-Str. 58, DE-48149 Münster, Germany.

Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules. PN evolves along with chronic pruritus in the context of diverse dermatological, systemic, neurological or psychiatric conditions. Permanent scratching is possibly a major trigger of PN, although its exact pathophysiology remains unclear. Read More

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http://dx.doi.org/10.2340/00015555-2774DOI Listing
February 2018
9 Reads

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review.

J Dermatol 2018 Feb 23;45(2):211-215. Epub 2017 Oct 23.

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2-year history of vitiligo and long-term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Read More

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http://dx.doi.org/10.1111/1346-8138.14106DOI Listing
February 2018
16 Reads

Lichen Simplex Chronicus as an Essential Part of the Dermatologic Masquerade.

Open Access Maced J Med Sci 2017 Jul 24;5(4):556-557. Epub 2017 Jul 24.

Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Polyclinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.

A 48 years old female patient had been suffering from the lesions presented for four years. They have started as small, pruritic patches which had been mechanically irritated and grew up in time. The patient had no associated comorbidities or allergies, and she was not under any medication. Read More

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http://dx.doi.org/10.3889/oamjms.2017.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535688PMC
July 2017
30 Reads

Possible role of Helicobacter pylori in diseases of dermatological interest.

J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

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July 2017
53 Reads

Psychiatric disorders and pruritus.

Clin Dermatol 2017 May - Jun;35(3):273-280. Epub 2017 Jan 22.

Department of Dermatology and Itch Center, Miller School of Medicine, University of Miami Medical Center, Miami, Florida. Electronic address:

The skin and psyche are intimately related with various skin diseases caused by or resulting in psychiatric disturbances. Pruritus is a commonly reported symptom in psychiatric patients, and likewise psychiatric co-morbidities, including anxiety and depression, are frequently seen in chronic pruritus patients. Primary psychodermatologic conditions, such as somatic symptom disorder, dermatitis artefacta, obsessive-compulsive and related disorders (excoriation disorder and prurigo nodularis), delusional infestation, and substance use disorder, can all induce significant pruritus in patients, severely affecting their quality of life. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.01.008DOI Listing
November 2017
67 Reads

Dissociation and conversion symptoms in dermatology.

Clin Dermatol 2017 May - Jun;35(3):267-272. Epub 2017 Jan 21.

Department of Medicine, Faculty of Medicine, University of Toronto, Ontario, Canada.

Dissociation and conversion (defined as the somatic component of dissociation) can play an important mediating role in the exacerbation of the stress-reactive dermatoses (eg, psoriasis, idiopathic urticaria, atopic dermatitis), dermatoses that are exacerbated by excessive scratching (eg, lichen simplex chronicus, prurigo nodularis) and koebnerization, and the self-induced dermatoses (dermatitis artefacta, acne excoriée, skin picking disorder, trichotillomania, onychotillomania/onychophagia). Dissociative symptoms often coexist with obsessive-compulsive symptoms in the more severe cases of the self-induced dermatoses. Dissociation can play an important role in cutaneous sensory disorder (eg, scalp dysesthesia syndrome, stomatodynia/glossodynia, vulvodynia/scrotodynia, medically unexplained anesthesia). Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.01.003DOI Listing
November 2017
17 Reads

Acquired elastotic hemangioma-like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus/prurigo nodularis-like lesions of the knee and elbow.

J Cutan Pathol 2017 Apr 4. Epub 2017 Apr 4.

Sikl's Department of Pathology, Charles University in Prague, Medical Faculty in Pilsen, Pilsen, Czech Republic.

Background: The so-called acquired elastotic hemangioma (AEH) represents a peculiar vascular lesion affecting the sun-damaged skin of the extensor surface of the forearms or the lateral aspect of the neck of middle-aged or elderly women.

Methods: This is a clinicopathological and immunohistochemical study of a series of 6 lesions located on the knee or elbow showing epithelial features of lichen simplex chronicus (LSC)/prurigo nodularis (PN) with a marked subepidermal vascular proliferation closely resembling AEH.

Results: Microscopically, all cases of cutaneous lesions showed epithelial features of LSC/PN, that is compact hyperkeratosis with focal parakeratosis, irregular acanthosis, prominent hypergranulosis. Read More

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http://dx.doi.org/10.1111/cup.12945DOI Listing
April 2017
28 Reads

There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations.

Exp Dermatol 2017 10 10;26(10):969-971. Epub 2017 Jul 10.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Prurigo nodularis (PN) is a pruritic condition with altered epidermal neuroanatomy as demonstrated previously. Here we elucidated neuroimmunological mechanisms by combining functional, morphological and gene expression experiments in twelve subjects with PN and eight healthy controls. Subjects with PN showed a reduced intra-epidermal nerve fibre density (IENFD) in lesional skin. Read More

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http://dx.doi.org/10.1111/exd.13343DOI Listing
October 2017
16 Reads

Immunoglobulin G4-related disease and its skin manifestations.

J Dermatol 2017 Mar;44(3):288-296

Department of Dermatology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory condition characterized by tissue infiltration with IgG4 plasma cells and an elevated serum IgG4 level. It usually occurs in middle-aged or older patients, with male predominance, and can involve multiple organs synchronously or metachronously. Patients with IgG4-RD generally respond to steroid therapy. Read More

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http://doi.wiley.com/10.1111/1346-8138.13723
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http://dx.doi.org/10.1111/1346-8138.13723DOI Listing
March 2017
15 Reads

[Discolouration of Upper Lid Skin - Prurigo nodularis].

Klin Monbl Augenheilkd 2017 Jan 30;234(1):33-35. Epub 2017 Jan 30.

Augenklinik der Universitätsmedizin, Ernst-Moritz-Arndt-Universität Greifswald.

An abnormal change in skin colour is designated as discolouration of the skin. A 73-year-old male patient with circumscribed discolouration of the upper lid margin near the lacrimal pathway is presented. Slit lamp biomicroscopy showed no other signs of pathomorphological change. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-120541
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http://dx.doi.org/10.1055/s-0042-120541DOI Listing
January 2017
11 Reads

Psoriasiform dermatitides: A brief review.

Authors:
Mark R Wick

Semin Diagn Pathol 2017 May 14;34(3):220-225. Epub 2016 Dec 14.

Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Room 3020, University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, United States. Electronic address:

Psoriasis vulgaris (PV)-the prototypical "psoriasiform" dermatitis-may assume a spectrum of histologic appearances, depending on whether it has been treated or not. Because of that relative lack of morphological uniformity, other skin disorders that feature epidermal acanthosis, with or without associated inflammation, may be confused diagnostically with PV. This brief review considers the clinicopathologic attributes of PV and its imitators, including chronic spongiotic dermatitides, lichen simplex chronicus, prurigo nodularis, pityriasis rubra pilaris, psoriasiform secondary syphilis, and Reiter syndrome. Read More

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http://dx.doi.org/10.1053/j.semdp.2016.12.006DOI Listing
May 2017
7 Reads

A case of levocetirizine-induced liver injury.

Clin Mol Hepatol 2016 Dec 25;22(4):495-498. Epub 2016 Dec 25.

Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity, but a liver biopsy was not performed. In this article, we present the first case of levocetirizine-induced liver injury with histologic findings. Read More

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http://dx.doi.org/10.3350/cmh.2016.0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266344PMC
December 2016
17 Reads

[Intrahepatic cholestasis of pregnancy : Rare but important].

Hautarzt 2017 Feb;68(2):95-102

Klinik für Hautkrankheiten und Kompetenzzentrum chronischer Pruritus (KCP), Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland.

Intrahepatic cholestasis of pregnancy (ICP) is a liver-specific disorder occurring in approximately 0.5-2.0% of all pregnancies with a considerable variation in certain ethnic groups. Read More

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http://dx.doi.org/10.1007/s00105-016-3923-yDOI Listing
February 2017
6 Reads