1,678 results match your criteria Prurigo Nodularis


Whole exome sequencing identified two point mutations of COL7A1 and FLG in a Chinese family with dystrophic epidermolysis bullous pruriginosa and ichthyosis vulgaris.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.

We report a 21-year-old man with recurrent bullous eruptions and severe itching on the lower legs and feet since 5 years of age. Dry, dirty brown, tile-like scales covered his lower legs with dystrophic toenails. Nodular prurigo-like lesions, scarring papules and milia remitted after the bullous eruptions. Read More

View Article
December 2018

Clinical characteristics and genetic variation in atopic dermatitis patients with and without allergic contact dermatitis.

Eur J Dermatol 2018 Oct;28(5):637-643

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

In patients with atopic dermatitis (AD), the risk of contact sensitization may be higher as the disrupted skin barrier may increase the penetration of contact allergens. Therefore, it is necessary to screen for concurrent allergic contact dermatitis (ACD) in AD patients. To identify the clinical characteristics and genetic variation in AD patients with concurrent ACD. Read More

View Article
October 2018

Serum cytokine profiling in patients with actinic prurigo.

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, General Hospital "Dr. Manuel Gea González", Mexico City, Mexico.

View Article
December 2018
1 Read

Allergic contact dermatitis due to chloramphenicol with prurigo nodularis-like spreading.

Contact Dermatitis 2018 Nov 28. Epub 2018 Nov 28.

Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Italy.

Topical drugs containing chloramphenicol and clostridiopeptidase A are frequently used for the treatment of cutaneous ulcers and other necrotic lesions. Chloramphenicol is a bacteriostatic broad-spectrum antibiotic widely used in eye and skin ointments to treat bacterial infections and a well-known cause of allergic contact dermatitis (ACD) (1). Clostridiopeptidase A, also called collagenase 1, is a proteolytic enzyme facilitating the tissue granulation with consequent re-epithelization; it has rarely been reported as cause of ACD (2). Read More

View Article
November 2018
1 Read

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, University of California, Irvine.

Importance: Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety of systemic pathways, including the immune system, in low doses of 1.5 to 4. Read More

View Article
November 2018
4 Reads

[Epidemiological and clinical aspects of prurigo in HIV infected patients in Fousseyni N'Daou hospital of Kayes, Mali].

Mali Med 2018 ;33(2):13-16

Faculté de médecine et d'Odontostomatologie.

Introduction: Prurigo is one of the most common dermatological conditions during HIV infection and AIDS. It appears as an immunosuppression marker associated with HIV infection. The study objective was to determine the prevalence of prurigo in people living with the human immunodeficiency virus (PLHIV) in Fousseyni N'Daou Hospital of Kayes, and to describe the socio-demographic aspects of patients and lesions associated with prurigo among PLHIV. Read More

View Article
January 2018
2 Reads

Use of antiepileptic mood stabilizers in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):756-764. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Several antiepileptic drugs (AEDs) are approved by the US Food and Drug Administration for the treatment of bipolar disorder (valproic acid, divalproex, lamotrigine, carbamazepine) and some cutaneous neuropathic pain syndromes (carbamazepine, gabapentin, pregabalin). The AEDs may be effective in the management of (1) chronic pruritus, including pruritus due systemic disease, including uremia, neuropathic pain, neuropathic pruritus, and complex cutaneous sensory syndromes, especially where central nervous system (CNS) sensitization plays a role; (2) management of emotional dysregulation and the resultant repetitive self-excoriation or other cutaneous self-injury in patients who repetitively stimulate or manipulate their integument to regulate emotions (prurigo nodularis, lichen simplex chronicus, skin picking disorder, trichotillomania); (3) management of dermatologic clinical manifestations associated with autonomic nervous system activation (hyperhidrosis, urticaria, flushing; these often occur in conjunction with psychiatric disorders with prominent autonomic activation and dysregulation, eg, social anxiety disorder, posttraumatic stress disorder); and (4) when certain anticonvulsants have a direct therapeutic effect (eg, in psoriasis); currently the use of AEDs for such cases is largely experimental. Gabapentin (dosage range 300-3600 mg daily) is the most widely studied AED mood stabilizer in dermatology and is especially effective in situations where CNS sensitization is a mediating factor. Read More

View Article
August 2018
5 Reads

Dupilumab Treatment for Generalized Prurigo Nodularis.

JAMA Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, University of California, San Francisco, San Francisco.

View Article
November 2018
5 Reads

Reduced Itch Associated With Dupilumab Treatment In 4 Patients With Prurigo Nodularis.

JAMA Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.

View Article
November 2018

Autoimmune Progesterone Dermatitis Diagnosed by Lymphocyte Transformation Test and Progesterone Provocation Test.

Acta Dermatovenerol Croat 2018 Oct;26(3):276-277

Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology University Hospital Center Zagreb School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Autoimmune progesterone dermatitis (APD) is rare autoimmune response to endogenous progesterone or to earlier exposure to exogenous progesterone (1). Skin lesions typically occur due to increases in progesterone during the luteal phase of the menstrual cycle (2). A-31-year-old mother of two children presented to our Department with a 5-year history of pruritic and painful erythematosus macules, papules, and patches on her neck, pectoral region, and face, which appeared 2-3 days before the onset of menses and gradually resolved 7-10 days later (Figure 1). Read More

View Article
October 2018
6 Reads

Prurigo pigmentosa - Response to treatment with Q-Switched neodymium: YAG at 532 nm.

Australas J Dermatol 2018 Oct 30. Epub 2018 Oct 30.

The Royal Children's Hospital, Melbourne, Victoria, Australia.

View Article
October 2018

Prurigo with systemic sclerosis successfully treated with narrow-band UVB phototherapy.

Eur J Dermatol 2018 Oct 25. Epub 2018 Oct 25.

Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520-2192, Japan.

View Article
October 2018
1 Read

[Kaposi sarcoma in a patient with ANCA vasculitis requiring hemodialysis].

Rev Med Interne 2018 Dec 10;39(12):942-945. Epub 2018 Oct 10.

Service de Néphrologie, de dialyse et de transplantation rénale, CHU La Rabta, Tunis, Tunisie; Faculté de Médecine de Tunis, Université Tunis El Manar, Tunis, Tunisie.

Introduction: Iatrogenic Kaposi's sarcoma is widely reported after transplantation. Less commonly, it occurs in patients receiving immunosuppressive therapy for ANCA associated vasculitis. We report here the rare association of Kaposi's sarcoma, prurigo nodularis and ANCA associated vasculitis in a hemodialysis patient. Read More

View Article
December 2018
6 Reads

Position Statement: Linear prurigo is a subtype of chronic prurigo.

J Eur Acad Dermatol Venereol 2018 Oct 5. Epub 2018 Oct 5.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Background: Chronic prurigo (CPG) is a distinct disease characterized by chronic pruritus, history and/or signs of prolonged scratching and multiple pruriginous lesions. It may present with various clinical manifestations, including papules, nodules, plaques or umbilicated lesions. Some patients with chronic pruritus show pruriginous linear and scaring scratch lesions (LSSL) and it is unclear whether these lesions belong to the spectrum of CPG. Read More

View Article
October 2018
14 Reads

A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics.

J Am Acad Dermatol 2018 Oct 1. Epub 2018 Oct 1.

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois. Electronic address:

Background: Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms.

Objective: To determine the prevalences of AD characteristics and differences by region and age.

Methods: A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii that analyzed the proportion of AD characteristics. Read More

View Article
October 2018
1 Read

Frequency of occurrence of polymorphic light eruption in patients treated with photohardening and patients treated with phototherapy for other diseases.

Photodermatol Photoimmunol Photomed 2018 Sep 29. Epub 2018 Sep 29.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Background: Medical phototherapy can lead to the manifestation of polymorphic light eruption (PLE), though little is known about the frequency of such events.

Aims: The aim of this Austrian single center study was to retrospectively investigate over a 4-year time period the frequency of PLE in patients prone to the condition and patients with other diseases under phototherapy (mainly narrow-band and broad-band UVB).

Materials And Methods: The data for analysis were obtained from the electronic health and patient record database and patient files of the Photodermatology Unit, Department of Dermatology, Medical University of Graz, Austria. Read More

View Article
September 2018
3 Reads

A systematic review of evidence-based treatments for prurigo nodularis.

J Am Acad Dermatol 2018 Sep 25. Epub 2018 Sep 25.

Department of Dermatology, George Washington Medical Faculty Associates, Washington, DC; Department of Dermatology, George Washington School of Medicine and Health Sciences, Washington, DC. Electronic address:

Prurigo nodularis is a chronic dermatologic condition involving the development of multiple cutaneous nodules in the setting of intractable pruritus. Given emerging treatment options for this difficult-to-treat condition, a current review of therapeutics is needed. A systematic review was performed for clinical studies investigating prurigo nodularis treatment published from 1990 to present including ≥5 subjects. Read More

View Article
September 2018
22 Reads

The Prevalence of Psychiatric Comorbidity in Patients with Prurigo Nodularis.

Indian Dermatol Online J 2018 Sep-Oct;9(5):318-321

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Prurigo nodularis (PN) is a chronic, recalcitrant itchy dermatosis. It is supposed to be associated with psychological factors, but research in this area is scarce.

Objectives: To study the prevalence and determinants of psychiatric morbidity, and the phenomenology of itch in PN. Read More

View Article
September 2018
8 Reads

Omalizumab Therapy in a Patient with Cronic Spontaneous Urticaria, Ulcerative Colitis, Hypereosinophilia and Prurigo Besnier: A Case Report.

J Dermatolog Treat 2018 Sep 26:1-11. Epub 2018 Sep 26.

a Dermatologic Clinic, Sapienza University of Rome , Viale del Policlinico 155 , Rome , 00161 , Italy.

The case of a woman who suffered from CSU and prurigo Besnier, with a history of chronic hyper-eosinophilia, ulcerative colitis and thyroiditis, unresponsive to anti-histamines and steroids is reported. The patient received omalizumab treatment, and obtained resolution of urticaria along with improvement of cutaneous symptoms of prurigo. Read More

View Article
September 2018
2 Reads

Prurigo Nodularis after Radiotherapy: An Isoradiotopic Response?

Case Rep Dermatol Med 2018 13;2018:9186745. Epub 2018 Aug 13.

Department of Plastic Surgery, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark.

Prurigo nodularis is a rare and chronic skin disorder with multiple, pruritic, and firm nodules. The exact pathophysiology is still unknown. Skin disorders appearing at sites of radiation can be defined as isoradiotopic. Read More

View Article

Linear IgA bullous dermatosis presenting as chronic prurigo: unveiling of the diagnosis by serrated pattern analysis.

Int J Dermatol 2018 11 19;57(11):e147-e149. Epub 2018 Sep 19.

Department of Dermatology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, India.

View Article
November 2018
1 Read

Occurrence, Chronicity and Intensity of Itch in a Clinical Consecutive Sample of Patients with Skin Diseases: a Multi-centre Study in 13 European Countries.

Acta Derm Venereol 2018 Sep 18. Epub 2018 Sep 18.

Institute of Medical Psychology, Justus-Liebig-University, Klinikstraße 29, DE-35392 Gießen, Germany.

Itch is an unpleasant symptom, affecting many dermatological patients. Studies investigating the occurrence and intensity of itch in dermatological patients often focus on a single skin disease and omit a control group with healthy skin. The aim of this multi-centre study was to assess the occurrence, chronicity and intensity (visual analogue scale 0-10) of itch in patients with different skin diseases and healthy-skin controls. Read More

View Article
September 2018
2 Reads

Gorlin Syndrome Presentation and the Importance of Differential Diagnosis of Skin Cancer: A Case Report.

J Pharm Pharm Sci 2018 ;21(1s):222s-224s

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.

In a busy community practice, clinical skin findings can often be misinterpreted. Skin cancers can sometimes mimic rashes like psoriasis, eczema or prurigo nodularis in both appearance and symptoms. Gorlin syndrome is one such genetic syndrome, characterized by the eruption of multiple and early onset basal cell carcinomas (BCCs), which can be mistaken for a rash. Read More

View Article
January 2018
2 Reads

Cross-European validation of the ItchyQoL in pruritic dermatoses.

J Eur Acad Dermatol Venereol 2018 Sep 7. Epub 2018 Sep 7.

Department of Dermatology and Center for Chronic Pruritus, University Hospital of Münster, Münster, Germany.

Background: Chronic pruritus (CP) is a frequently occurring symptom in inflammatory dermatoses, causing a high burden and limitations to health-related quality of life (HRQoL).

Objective: The ItchyQoL was developed to assess the impairment to HRQoL in patients with CP. However, it has only been validated in English and German. Read More

View Article
September 2018
1 Read

Breakfast, lunch, and dinner sign: a hallmark of flea and bedbug bites.

An Bras Dermatol 2018 Sep-Oct;93(5):759-760

Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu (SP), Brazil.

Human, dog, and cat fleas, as well as bedbugs, feed by biting their victims, causing acute prurigo, which is aggravated in sensitized victims (papular urticaria). The lesions appear in the classic "breakfast, lunch, and dinner" pattern. There are two main explanations: the parasites "map" the skin area in search of the best places to bite, and their removal when victim scratches, and then reattach to the skin. Read More

View Article
October 2018
4 Reads

Xerosis cutis and associated co-factors in women with prurigo nodularis.

An Bras Dermatol 2018 Sep-Oct;93(5):671-679

Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Background: Current data regarding the associated factors of prurigo nodularis are still uncertain, except for atopic predisposition.

Objectives: The purposes of this study were to (1) determine the frequencies of xerosis and other accompanying diseases of female patients with prurigo nodularis; (2) compare the demographic, clinical and accompanying disease characteristics by grouping these patients according to whether they have associated xerosis (who were subsequently subgrouped as atopic or non-atopic) or not.

Methods: In this retrospective descriptive study, 80 females with PN were categorized according to the accompanying diseases (dermatological, systemic, neurological, psychogenic, mixed, or undetermined origin). Read More

View Article
October 2018
4 Reads

Inflammatory dermatoses in human immunodeficiency virus.

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):113-120

Department of Dermatology and S.T.D., Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

Various inflammatory dermatoses have been described in association with human immunodeficiency virus (HIV) infection. These either present in the usual way or in varied atypical presentations. This article gives a brief review about the etiopathogenesis and clinical presentation of the common inflammatory dermatoses associated with HIV such as psoriasis, reactive arthritis, seborrheic dermatitis, eosinophilic folliculitis, pruritic papular eruption, photosensitivity disorders prurigo nodularis, atopic dermatitis, and ichthyosis. Read More

View Article
August 2018
8 Reads

Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: Results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial.

J Am Acad Dermatol 2018 Sep;79(3):457-463.e5

Center for Chronic Pruritus, Department of Dermatology, University Hospital of Münster, Münster, Germany.

Background: Chronic pruritus is a multifactorial, challenging symptom of global relevance.

Objective: The European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) investigation aimed to analyze the severity and humanistic burden of chronic pruritus in patients suffering from inflammatory dermatoses across Europe.

Methods: Prospectively collected routine data on 552 patients (with atopic dermatitis, contact dermatitis, prurigo nodularis, psoriasis vulgaris, lichen planus, or mycosis fungoides [pruritus numeric rating scale score ≥3]) from 9 European centers (in Austria, France, Germany, Italy, Poland, Russia, Spain, Switzerland, and Turkey) were analyzed by univariate and multivariate variance analyses of various itch characteristics and quality of life (as measured by the Dermatology Life Quality Index and the ItchyQoL). Read More

View Article
September 2018
5 Reads

An inside look at prurigo pigmentosa: case report from Ukraine.

Int J Dermatol 2018 Aug 13. Epub 2018 Aug 13.

Laboratory of Pathology, "CSD Health Care", Kyiv, Ukraine.

View Article
August 2018
6 Reads

Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients.

Case Rep Dermatol Med 2018 9;2018:9406797. Epub 2018 Jul 9.

Department of Dermatology, Jordan University Hospital, Amman, Jordan.

Prurigo pigmentosa is a unique cutaneous inflammatory disorder characterized by a sudden onset of pruritic and erythematous macules, urticarial papules, and plaques that may coalesce to form a reticulated pattern. Lesions typically heal within weeks leaving a reticulated and mottled postinflammatory hyperpigmentation. The majority of reported cases originate from Japan with much fewer cases described worldwide without predominant ethnicity. Read More

View Article
July 2018
10 Reads

[Prurigo pigmentosa during pregnancy].

Ann Dermatol Venereol 2018 Aug 10. Epub 2018 Aug 10.

Service de dermatologie, université Côte d'Azur, CHU, Nice, France; Inserm U1065, équipe 12, C3M, université Côte d'Azur, Nice, France. Electronic address:

Introduction: Prurigo pigmentosa is a rare inflammatory dermatosis characterized by pruritic and reticulate papules on the trunk leaving hyperpigmentation. This dermatosis has been rarely described outside Asia. The pathophysiology remains obscure. Read More

View Article
August 2018
9 Reads

Comprehending prurigo nodularis: Ay, there's the rub.

Authors:
Warren R Heymann

J Am Acad Dermatol 2018 Oct 6;79(4):636-637. Epub 2018 Aug 6.

Division of Dermatology, Cooper Medical School of Rowan University, Marlton, New Jersey. Electronic address:

View Article
October 2018
1 Read

The Value of Etiological Tests and Skin Biopsy in the Management of Prurigo Simplex Subacuta.

Acta Dermatovenerol Croat 2017 Dec;25(4):276-278

Suhan Günaştı Topal, MD, University of Çukurova, Department of Dermatology 01330 Balcalı, Sarıçam, Adana, Turkey;

It has been emphasized that prurigo simplex subacuta may be associated with various disorders and may be clinically confused with dermatitis herpetiformis. Aim of the study was to evaluate the value of our set of tests for finding possible associations and for the aforementioned differential diagnosis. Rates of implementations and abnormal results in our set of tests, including skin prick test, skin biopsy, complete blood count, blood chemistry panel, and psychiatric evaluation were analyzed retrospectively between the years of 2010 and 2015 in 130 patients clinically diagnosed with prurigo simplex subacuta. Read More

View Article
December 2017
2 Reads

[Importance of phototherapy in the treatment of chronic pruritus].

Authors:
Franz J Legat

Hautarzt 2018 Jul 13. Epub 2018 Jul 13.

Universitätsklinik für Dermatologie und Venerologie, Medizinische Universität Graz, Auenbruggerpl. 8, 8036, Graz, Österreich.

Phototherapy and photochemotherapy (PUVA) are important treatment modalities in inflammatory skin diseases such as psoriasis and atopic dermatitis as well as in cutaneous T‑cell lymphoma (e.g., mycosis fungoides/Sezary syndrome). Read More

View Article
July 2018
9 Reads

The utilization of phototherapy in the department of dermatology, Hospital Kuala Lumpur: A 5-year audit.

Med J Malaysia 2018 Jun;73(3):125-130

Hospital Kuala Lumpur, Department of Dermatology, Kuala Lumpur, Malaysia.

Introduction: Ultraviolet phototherapies are important treatment modalities for a wide range of dermatological conditions. We aim to describe the utilization of phototherapy in the Department of Dermatology Hospital Kuala Lumpur.

Methods: This is a 5-year retrospective audit on patients who underwent phototherapy between 2011 and 2015. Read More

View Article
June 2018
2 Reads

[Pruritus in elderly people-an interdisciplinary challenge].

Hautarzt 2018 Aug;69(8):647-652

Fachbereich Nephrologie, DKD Helios Klinik, Wiesbaden, Deutschland.

Due to demographic change, especially in Western countries with increasing life expectancy and a continuously increasing number of elderly, chronic pruritus (CP) is more and more observed in clinical practice. CP in elderly may present with specific pruritic skin diseases, as chronic prurigo (nodular form) and can also occur in unaffected, normal looking skin. CP in elderly remains a challenge. Read More

View Article
August 2018
1 Read

A case of chronic prurigo successfully treated with omalizumab.

Eur J Dermatol 2018 Oct;28(5):691-692

Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

View Article
October 2018
1 Read

Photocontact Dermatitis and Its Clinical Mimics: an Overview for the Allergist.

Clin Rev Allergy Immunol 2018 Jun 27. Epub 2018 Jun 27.

Department of Dermatology, The University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX, 75390-9069, USA.

Photo-contact dermatitis (PCD) describes the adverse cutaneous reaction that occurs in some patients as a result of simultaneous exposure to a contactant and to light. PCD can be subdivided into photo-allergic and photo-irritant dermatitis depending on whether the contactant respectively invokes an allergic or irritant reaction. Photo-irritant reactions are commonly caused by plants, psoralens, and medications taken internally, whereas photo-allergic reactions are commonly caused by sunscreens and topical nonsteroidal anti-inflammatory medications. Read More

View Article
June 2018
17 Reads

Itching at night: A review on reducing nocturnal pruritus in children.

Pediatr Dermatol 2018 Sep 26;35(5):560-565. Epub 2018 Jun 26.

Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

The most common causes of chronic nocturnal itching in children are atopic dermatitis and psoriasis, with lichen simplex chronicus and prurigo nodularis contributing to lesser degrees. Despite the prevalence of nocturnal itching, its pathophysiology remains poorly understood. The most troubling consequence of itching at night is poor quality of sleep. Read More

View Article
September 2018
14 Reads

Immunomodulating Agents as Antipruritics.

Dermatol Clin 2018 Jul 16;36(3):325-334. Epub 2018 Apr 16.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Campus Box 8123, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA; Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA; Center for the Study of Itch, Washington University School of Medicine, St Louis, MO, USA. Electronic address:

Chronic pruritus, or itch lasting greater than 6 weeks, is an increasingly common and debilitating medical problem. Recent studies have unveiled previously unrecognized neuroimmune axes whereby inflammatory cytokines act directly on the nervous system to promote itch. Thus, the emergence of newer targeted biologic therapies has generated the possibility of novel treatment strategies for chronic itch disorders. Read More

View Article
July 2018
3 Reads

Prurigo Nodularis and Its Management.

Dermatol Clin 2018 Jul 20;36(3):189-197. Epub 2018 Mar 20.

Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Von- Esmarch-Strasse 58, Münster DE-48149, Germany.

Prurigo nodularis occurs with chronic pruritus and the presence of single to multiple symmetrically distributed, hyperkeratotic, and intensively itching nodules. Diverse dermatologic, systemic, neurologic, or psychiatric conditions can lead to prurigo nodularis. Structural analysis demonstrated a reduced intraepidermal nerve fiber density and increased dermal levels of nerve growth factor and neuropeptides such as substance P and calcitonin gene-related peptide. Read More

View Article
July 2018
13 Reads

Chronic Prurigo: An Unusual Presentation of Hodgkin Lymphoma.

Case Rep Dermatol 2018 May-Aug;10(2):122-126. Epub 2018 May 17.

Department of Dermatology, Geneva University Hospital, Geneva, Switzerland.

Background: Prurigo nodularis is a condition of unknown origin defined by papulonodular eruption and intense pruritus. Hodgkin lymphoma often presents nonspecific initial symptoms. An association between systemic malignancy and cutaneous manifestations has long been documented. Read More

View Article
May 2018
8 Reads

The self-assessed psychological comorbidities of prurigo in European patients: a multicentre study in 13 countries.

J Eur Acad Dermatol Venereol 2018 Jun 19. Epub 2018 Jun 19.

Department of Dermatology, University Hospital, Brest, France.

Background: Prurigo is defined by the presence of chronic pruritus and multiple localized or generalized pruriginous lesions.

Objective: The aim of this study was to assess the psychological burden of prurigo in patients of European countries.

Methods: In this multicentre European study, 3635 general dermatology outpatients and 1359 controls were included. Read More

View Article
June 2018
12 Reads

Possible roles of basophils in chronic itch.

Exp Dermatol 2018 Jun 12. Epub 2018 Jun 12.

Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.

Basophils are blood granulocytes and normally constitute <1% of blood peripheral leucocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Read More

View Article
June 2018
18 Reads

Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need.

J Eur Acad Dermatol Venereol 2018 Dec 1;32(12):2224-2229. Epub 2018 Jul 1.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Background: Prurigo nodularis (PN) is a chronic skin condition characterized by intensely pruritic, hyperkeratotic papulonodular lesions that dramatically impairs patients' quality of life. Management of the condition is challenging, and there is no approved therapy in the United States or in Europe.

Objective: The key aim of this survey was to examine current perceptions of PN diagnosis and management among members of the European Academy of Dermatology and Venereology (EADV). Read More

View Article
December 2018
1 Read

Prurigo-like herpes simplex.

Authors:
Ajit Barve

Int J Dermatol 2018 08 27;57(8):e55-e57. Epub 2018 May 27.

7 Aradhana Adarsh Colony, Thane East, Thane, Maharashtra, India.

View Article
August 2018
2 Reads

Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders.

Am J Clin Hypn 2018 Jul;61(1):34-44

a University of South Florida , Tampa , FL, USA.

Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

View Article
July 2018
29 Reads

Treatment of Prurigo Pigmentosa with Diet Modification: A Medical Case Study.

Hawaii J Med Public Health 2018 May;77(5):114-117

Nutrition Services, Shriners Hospitals for Children, Honolulu, HI (MW).

Prurigo pigmentosa is a rare inflammatory dermatitis first described in 1971. While the etiology of Prurigo pigmentosa is yet unknown, conditions associated with ketosis often accompany this rash. Prurigo pigmentosa is successfully treated with antibiotics and by resolution of ketosis. Read More

View Article