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J Investig Allergol Clin Immunol 2020 Jun 23. Epub 2020 Jun 23.

Clinical Immunology Outpatient Clinic - Division of Internal Medicine, Department of Advanced Medical and Surgical Sciences, "Luigi Vanvitelli" University of Campania, Naples, Italy.

Int J Dermatol 2020 Jun 20. Epub 2020 Jun 20.

Alergoskin Alergia e Dermatologia, a UCARE Center, Santo André, São Paulo, Brazil.

Acta Derm Venereol 2020 Jun 17. Epub 2020 Jun 17.

Center for Chronic Pruritus, Department of Dermatology, University Hospital Münster, Münster, Germany.

Chronic nodular prurigo presents with multiple pruriginous nodules and severe pruritus. This study aims to explore the treatment course and regimens in patients with chronic nodular prurigo and to analyse predictive factors contributing to therapeutic success. A total of 325 patients with chronic nodular prurigo (m 37. Read More

Acta Derm Venereol 2020 Jun 18. Epub 2020 Jun 18.

Department of Dermatology, University Hospital of Brest, 47 rue Louis Pasteur, FR-29200 Brest, France. E-mail:

J Allergy Clin Immunol Pract 2020 Jun 9. Epub 2020 Jun 9.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address:

Ann Allergy Asthma Immunol 2020 Jun 1. Epub 2020 Jun 1.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO, 63110. Electronic address:

Objective: Chronic pruritus, or itch lasting >6 weeks, is a common symptom and has a profoundly negative impact on quality of life. While many primary dermatologic disorders such as atopic dermatitis and chronic urticaria are characterized by pruritus, numerous other allergic, hepatobiliary, lymphoproliferative, neurologic, and renal disorders are associated with chronic pruritus. Itch involves complex interactions orchestrated by a variety of factors released from and acting on the skin, immune system, and the sensory nervous system. Read More

J Cutan Med Surg 2020 Jun 4:1203475420931763. Epub 2020 Jun 4.

12303 Department of Dermatology, College of Medicine, Cincinnati, OH, USA.

J Eur Acad Dermatol Venereol 2020 Jun 3. Epub 2020 Jun 3.

The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Ann Dermatol Venereol 2020 May 28. Epub 2020 May 28.

Service de dermatologie, CHU de Brest, 2, avenue Foch, 29609 Brest cedex, France; Université de Brest, LIEN, 29200 Brest, France. Electronic address:

J Dtsch Dermatol Ges 2020 Jun 29;18(6):618-624. Epub 2020 May 29.

Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany.

J Am Acad Dermatol 2020 May 24. Epub 2020 May 24.

Johns Hopkins University School of Medicine, Department of Dermatology; Johns Hopkins University Bloomberg School of Public Health. Electronic address:

Prurigo nodularis (PN) is a chronic skin condition characterized by severely pruritic nodules that cause a profound negative impact on quality of life. In the second article of this 2-part continuing medical education series, we focus on reviewing pathogenesis of prurigo nodularis and explore management algorithms for this condition. Additionally, we will discuss some emerging and novel therapies for treating PN. Read More

J Am Acad Dermatol 2020 May 23. Epub 2020 May 23.

Johns Hopkins University School of Medicine, Department of Dermatology; Johns Hopkins University Bloomberg School of Public Health. Electronic address:

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intensely pruritic, hyperkeratotic nodules that favor the extensor surfaces of the extremities and the trunk. In addition to its significant impact on quality of life, many patients with PN are recalcitrant to therapy as there are currently no FDA approved therapies. In the first article of this 2-part continuing medical education series, we describe the broader epidemiology, patient demographics, physical exam findings, and symptoms to aid in the timely recognition and diagnosis of PN. Read More

Arerugi 2020 ;69(3):213-217

Department of Pediatrics, National Hospital Organization Fukuoka National Hospital.

Background: Prurigo nodularis is a chronic disease characterized by a hard dome-like or wart-like nodule which is solitary and does not fuse. Prurigo nodularis presents as one of the symptoms of atopic Dermatitis (AD).

Cases: We present three cases of AD children with intractable prurigo nodularis. Read More

Acta Derm Venereol 2020 May 28;100(10):adv00155. Epub 2020 May 28.

Department of Dermatology, University of Rzeszow, Szopena street 2, PL-35-055 Rzeszów, Poland.

Prurigo nodularis is a chronic skin condition that presents significant challenges for treatment and quality of life, with little known about disease prevalence. This study assessed the prevalence of prurigo nodularis in Poland using publicly maintained database case records and diagnostic codes for prurigo nodularis (L28.1) and other prurigo (L28. Read More

Int J Dermatol 2020 Jun 20;59(6):716-721. Epub 2020 Apr 20.

Dermatologic Clinic, Sapienza University of Rome, Rome, Italy.

Background: Atopic dermatitis (AD) is a chronic relapsing eczematous dermatitis typically affecting young patients in a percentage from 15 to 20%; although it typically affects young people and adults, recent papers highlighted the emerging of the disease in the elderly population.

Methods: The aim of the study was to identify the clinical criteria and allergic sensitization that may be able to support physicians and dermatologists in making a correct diagnosis of AD in the elderly. The second aim of this study was to investigate the incidence, the main features, the gender prevalence, the immunological profile, and comorbidities characterizing patients older than 65 years affected by AD. Read More

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

School of Medicine, University of California San Diego, La Jolla, CA.

Nevus sebaceus is a benign skin hamartoma of congenital onset that grows during puberty, and in adulthood can develop secondary benign and malignant neoplasms. The most common benign neoplasms occurring in nevus sebaceus are believed to be syringocystadenoma papilliferum, trichilemmoma, and trichoblastoma. A patient with nevus sebaceus developed not only syringocystadenoma papilliferum but also prurigo nodularis within her hamartomatous lesion; multiple biopsies were necessary to establish the diagnoses. Read More

Acta Derm Venereol 2020 Apr 21;100(8):adv00119. Epub 2020 Apr 21.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark.

Prurigo nodularis is a pruritic dermatosis with poor treatment options. To describe treatment patterns, comorbidities, pruritus, and quality of life a survey was administered to 92 patients with prurigo nodularis. A total of 52 patients completed the survey. Read More

Acta Derm Venereol 2020 Apr 21;100(8):adv00118. Epub 2020 Apr 21.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark.

J Am Acad Dermatol 2020 Apr;82(4):1035-1036

Dr Phillip Frost Department of Dermatology and Cutaneous Surgery and Itch Center Miller School of Medicine, University of Miami, Miami, Florida. Electronic address:

Arch Dermatol Res 2020 Feb 20. Epub 2020 Feb 20.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Suite 2B-425, 2150 Pennsylvania Avenue NW, Washington, DC, 20037, USA.

Prurigo nodularis (PN) and lichen simplex chronicus (LSC) are debilitating chronic pruritic diseases that can lead to and be exacerbated by psychosocial distress. However, little is known about the mental health (MH) comorbidities of PN/LSC. We sought to evaluate the likelihood and cost-burden of MH comorbidities and emergencies associated with PN/LSC. Read More

N Engl J Med 2020 02;382(8):757-758

From the Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore.

N Engl J Med 2020 02;382(8):706-716

From the Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster (S.S.), the Department of Dermatology and Allergy, Christine Kühne Center for Allergy Research and Education, University Hospital, Bonn (T.B.), and the Department of Dermatology and Allergy, Ludwig Maximilian University of Munich, Munich (A.W.) - all in Germany; the Itch Center, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Hospital, Miami (G.Y.); the Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria (F.J.L.); the Department of Dermatology, University Hospital of Nice, Nice (J.-P.L.), the Department of Dermatology, University of Toulouse, Toulouse (C. Paul), and the Department of Dermatology, University Hospital of Brest, Brest (L.M.) - all in France; the Department of Dermatology, Medical University of Lodz, Lodz (J.N.), and the Department of Dermatology, University of Rzeszow, Rzeszow (A.R.) - both in Poland; Galderma, Fort Worth, TX (F.A.); and Galderma, Lausanne, Switzerland (C. Piketty).

Background: Prurigo nodularis is a chronic pruritic skin disease with multiple nodular skin lesions. Nemolizumab is a monoclonal antibody targeting the interleukin-31 receptor, which is involved in the pathogenesis of prurigo nodularis.

Methods: We conducted a 12-week, randomized, double-blind, phase 2 trial of nemolizumab (at a dose of 0. Read More

J Dermatolog Treat 2020 Feb 21:1-2. Epub 2020 Feb 21.

Department of Medicine, Division of Dermatology, University of Arizona, Tucson, AZ, USA.

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology, University of California San Diego, San Diego, CA.

Bullous pemphigoid (BP) is an autoimmune blistering disorder that predominantly affects the elderly. Treatment regimens typically include topical and systemic immunosuppressive medications. Although effective, systemic corticosteroids are sometimes poorly tolerated in the elderly patient, contributing to the overall morbidity and mortality of BP. Read More

Br J Dermatol 2020 Feb 4. Epub 2020 Feb 4.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Postepy Dermatol Alergol 2019 Dec 9;36(6):659-666. Epub 2019 Apr 9.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

Chronic dermatoses, including atopic dermatitis, psoriasis, prurigo nodularis, chronic spontaneous urticaria and hidradenitis suppurativa, as well as accompanying subjective symptoms (itch and pain), have a great impact on patients' well-being. Skin plays an important role in the physiological sleep process. This review attempts to analyze the association between chronic dermatoses in adults and sleep quality in recent studies. Read More

J Am Acad Dermatol 2020 May 25;82(5):1205-1212. Epub 2020 Jan 25.

Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Medical marijuana is becoming widely available to patients in the United States, and with recreational marijuana now legalized in many states, patient interest is on the rise. The endocannabinoid system plays an important role in skin homeostasis in addition to broader effects on neurogenic responses such as pruritus and nociception, inflammation, and immune reactions. Numerous studies of in vitro and animal models have provided insight into the possible mechanisms of cannabinoid modulation on pruritus, with the most evidence behind neuronal modulation of peripheral itch fibers and centrally acting cannabinoid receptors. Read More

JAAD Case Rep 2020 Jan 24;6(1):3-5. Epub 2019 Dec 24.

University of Arizona College of Medicine, Tucson, Arizona.

Medicines (Basel) 2020 Jan 8;7(1). Epub 2020 Jan 8.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

: Prurigo nodularis (PN) is an intensely pruritic skin condition of considerable morbidity. However, the pathogenesis of PN and its association with underlying neuropathy is unclear. : We sought to investigate the association between PN and etiologies of peripheral neuropathy. Read More

Dermatol Ther 2020 Mar 16;33(2):e13222. Epub 2020 Jan 16.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Dupilumab is a recombinant complete human monoclonal antibody modulating the signaling of interleukin-4 and interleukin-13 pathways and has been approved for the treatment of moderate/severe atopic dermatitis. Here, we present three cases of prurigo nodularis treated off-label with dupilumab, and a review of the existing literature. All patients in this study had longstanding severe disease and had tried multiple treatment modalities. Read More

J Dermatol 2020 Mar 6;47(3):283-289. Epub 2020 Jan 6.

Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Chronic prurigo is classified into two clinical subtypes: prurigo nodularis (PN) and prurigo chronica multiformis (PCM) in Japan. In this study, we retrospectively investigated the clinical features of 168 patients with chronic prurigo (103 with PN and 65 with PCM) diagnosed at the Tokyo Medical and Dental University, and compared age, sex, prevalence of comorbidities, blood test results, histology and treatment efficacy in both groups. We found that patients with PCM were significantly older than those with PN. Read More

J Dermatolog Treat 2020 Jan 3:1-4. Epub 2020 Jan 3.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Dermatol Ther 2020 01 28;33(1):e13201. Epub 2019 Dec 28.

Medical Sciences Department, Dermatologic Clinic, University of Turin, Turin, Italy.

Prurigo nodularis (PN) is a chronic disorder, affecting adults, with multiple nodules, typically on the limbs. The treatment is challenging, especially in elderly patients. An 85-year-old woman had developed in the last 3 years itch with nodular lesions and erythematous scaly patches and excoriations. Read More

Dermatol Ther (Heidelb) 2020 Feb 16;10(1):107-117. Epub 2019 Nov 16.

Department of Dermatology, University of California, San Francisco, CA, USA.

Introduction: In order to manage skin conditions at a national referral hospital level in Kenya, specialized dermatology services, such as dermatologic surgery, dermatopathology, phototherapy, and sub-specialty care, should be offered, as is typically available in referral hospitals around the world. A Kenyan patient with prurigo nodularis, whose severe itch remitted after phototherapy treatment at the University of California, San Francisco (UCSF), inspired the development of a phototherapy service at Academic Model Providing Access to Healthcare (AMPATH), a partnership in Western Kenya between Moi Teaching and Referral Hospital, Moi University College of Health Sciences, and a consortium of North American academic medical centers.

Methods: Initial project funds were raised through a crowdfunding campaign and fundraising events. Read More

J Dermatolog Treat 2019 Nov 12:1-10. Epub 2019 Nov 12.

Department of Medicine, Division of Dermatology, University of Arizona, Tucson, AZ, USA.

While dupilumab has emerged as an effective treatment for moderate-to-severe atopic dermatitis (AD) since its approval in 2017, interleukin-4 and 13 blockade has also demonstrated efficacy in off-label chronic dermatologic conditions. To identify chronic dermatologic conditions in which dupilumab has demonstrated efficacy. Thirty-three reports of dupilumab use in non-AD dermatologic conditions were identified through systematic literature review. Read More

Proc (Bayl Univ Med Cent) 2019 Oct 5;32(4):587-588. Epub 2019 Aug 5.

Department of Dermatology, Texas Tech University Health Sciences CenterLubbockTexas.

Hodgkin's disease (HD) is a common malignant lymphoma that classically presents with painless lymphadenopathy, weight loss, nocturnal sweats, fever, and generalized pruritus. Unlike other lymphoproliferative disorders, cutaneous involvement is uncommon with HD. Diffuse hyperpigmentation, prurigo nodularis, acquired ichthyosis, erythema nodosum, mycosis fungoides, herpes zoster, and vasculitis have all been described as nonspecific or paraneoplastic manifestations of HD. Read More

J Drugs Dermatol 2019 Oct;18(10)

Dupilumab inhibits the interleukin-4 receptor subunit α and is FDA approved for treatment of moderate-to-severe atopic dermatitis. It is a relatively new drug, and whether it is efficacious for other diseases in dermatology is an area of increasing interest. We searched the literature and ClinicalTrials. Read More

Medicines (Basel) 2019 Sep 27;6(4). Epub 2019 Sep 27.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Pruritus is a common disease symptom with a variety of etiologies known to reduce patient quality of life. We aimed to characterize the racial and gender differences in the presentation of pruritus for itch-related patient visits both within a single institution and nationally. Cross sectional study of patients ≥ 18 years old seen at Johns Hopkins Health System between 1/1/12 and 1/1/18. Read More

Eur J Pharmacol 2019 Dec 27;864:172702. Epub 2019 Sep 27.

Center for Substance Abuse Research, Lewis Katz Medical School at Temple University, Philadelphia, PA, USA; Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Chronic itch is one of the disturbing symptoms of inflammatory skin diseases. Kappa opioid receptor agonists are effective in suppressing scratching in mice against different pruritogens. Nalbuphine, a nonscheduled kappa opioid receptor agonist and mu opioid receptor antagonist, has been in clinical use for post-operative pain management since the 1980s and recently has been in clinical trials for chronic itch of prurigo nodularis (https://www. Read More

J Dtsch Dermatol Ges 2019 10 27;17(10):1039-1051. Epub 2019 Sep 27.

Department of Dermatology, University Hospital, Jena, Germany.

Eosinophilic dermatoses are a heterogeneous group of diseases, characterized by an eosinophil-rich infiltrate and/or degranulation of eosinophils. Blood eosinophilia may be an associated feature. Typical, albeit not specific histological findings include 'flame figures', which are caused by the accumulation of cationic proteins released by eosinophils and subsequent collagen denaturation. Read More

Medicines (Basel) 2019 Sep 26;6(4). Epub 2019 Sep 26.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the pathogenesis of PN. There are several associated etiologic factors thought to be associated with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. Read More

Indian J Dermatol 2019 Sep-Oct;64(5):341-345

Department of Skin and VD, Mysore Medical College and Research Institute, Mysore, Karnataka, India.

Background: A dermoscope is an office tool used in the diagnosis of various disorders. At present, studies on hypertrophic lichen planus (HLP) and prurigo nodularis (PN) are limited.

Aims And Objectives: The aim of this study was to compare the dermoscopic features of HLP and PN and to determine the role of dermoscopy in the differential diagnosis of both the conditions. Read More

J Eur Acad Dermatol Venereol 2020 Feb 17;34(2):e74-e76. Epub 2019 Oct 17.

Dermatology Department, Saint-Louis Hospital, APHP, Paris, France.

J Drugs Dermatol 2019 Sep;18(9):940-942

Prurigo nodularis (PN) is a disease in which chronic scratching and picking of the skin due to intense pruritis results in papulonodules, notably in areas that are accessible to the patient. The pathophysiology is hypothesized to be mediated by a Th2 helper cell response, similar to that seen in atopic dermatitis, therefore, treatment of PN with dupilumab would be expected to elicit a therapeutic response. We demonstrated that treatment of PN with dupilumab significantly decreased pruritis and the size and number of new lesions after 2 months of treatment. Read More

J Am Acad Dermatol 2020 Jan 12;82(1):34-36. Epub 2019 Sep 12.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland. Electronic address:

Dermatitis 2020 Jan 3. Epub 2020 Jan 3.

Department of Health Sciences, University Magna Graecia of Catanzaro, Italy.

Background: Generalized prurigo nodularis (GPN) is a debilitating, inflammatory skin disease characterized by chronic pruritus, signs of prolonged scratching, and multiple pruriginous papules and nodules. Recent studies identified several forms of GPN as a clinical phenotype of adult atopic dermatitis (AD).

Objective: The aim of the study was to evaluate the effectiveness of dupilumab (D) in adults affected by persistent AD showing a clinical feature of GPN. Read More

Dermatol Ther (Heidelb) 2019 Dec 11;9(4):613-622. Epub 2019 Sep 11.

Department of Dermatology and Center for Chronic Pruritus, University Hospital of Münster, Münster, Germany.

Chronic prurigo is an extremely severe pruritic skin disease which presents with multiple, hyperkeratotic and erosive papules, nodules and/or plaques. Patients with this high-burden disease require effective therapies, but effective treatments with regulatory agency approval are currently lacking. Deeper understanding of the pathophysiology suggests that hypersensitive nerves play an important role in the development of chronic prurigo. Read More

J Am Acad Dermatol 2020 May 6;82(5):1117-1123. Epub 2019 Sep 6.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Electronic address:

Background: Because of reduced mortality, patients with HIV are living longer and presenting with chronic diseases. Little is known about racial differences in dermatologic conditions associated with HIV infection.

Objective: This study examines associated dermatologic conditions in a large population of patients with HIV at a tertiary care center with a diverse patient population. Read More

J Invest Dermatol 2020 Mar 30;140(3):702-706.e2. Epub 2019 Aug 30.

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

J Eur Acad Dermatol Venereol 2019 Dec 12;33(12):2371-2379. Epub 2019 Sep 12.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Background: Aprepitant is a neurokinin 1 receptor (NK1R) antagonist used for its antipruritic properties in dermatoses and systemic diseases. The mode of action is still unclear. A peripheral effect is assumed as aprepitant shows efficacy in inflammatory skin diseases including prurigo nodularis (PN). Read More