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Actas Dermosifiliogr 2022 Jun 28;113(6):T563-T574. Epub 2022 Apr 28.

Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain.

Chronic prurigo is itself a common condition, but it can also occur secondary to a large number of diseases. Management is challenging as historically chronic prurigo has been poorly defined and very few treatments are available. Clinically, it presents as excoriated, hyperkeratotic lesions. Read More

Dermatol Ther 2022 Jun 16:e15642. Epub 2022 Jun 16.

Zunyi Medical University, Zunyi, China.

Actas Dermosifiliogr 2022 Jun 9. Epub 2022 Jun 9.

Servicio de Dermatología. Hospital General de Alicante, España.

Interleukin 31 (IL-31) is a neurocytokine that stimulates sensory neurons involved in pruritus. It contributes to skin barrier inflammation, dysfunction, and remodeling. As the immune and nervous systems are interrelated, IL-31 has a key role in the treatment of atopic dermatitis (AD) and prurigo nodularis (PN). Read More

Acta Derm Venereol 2022 Jun 7. Epub 2022 Jun 7.

Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 76, Stockholm, Sweden.

Skin Health Dis 2022 Mar 1;2(1):e75. Epub 2021 Dec 1.

Department of Dermatology Peking University Shenzhen Hospital Shenzhen Guangdong China.

Background: Prurigo nodularis (PN) is a highly pruritic, chronic dermatosis and difficult to treat. PN lesions are characterized by existence of many hyperkeratotic, erosive papules and nodules. However, the pathogenesis of PN still remains unelucidated. Read More

Br J Dermatol 2022 Jun 3. Epub 2022 Jun 3.

Univ Brest, LIEN, Brest, France.

Chronic prurigo is a distinct disease defined by the presence of chronic pruritus for at least 6 weeks, a history and/or signs of repeated scratching, and multiple localized or generalized pruritic skin lesions (whitish or pinkish papules, nodules and/or plaques). Although chronic prurigo is frequently named prurigo nodularis, the nodular type of chronic prurigo is only the main clinical aspect of chronic prurigo. Chronic prurigo occurs due to neural sensitization to pruritus and the development of a vicious pruritus-scratching cycle. Read More

Brain Sci 2022 May 5;12(5). Epub 2022 May 5.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Prurigo nodularis (PN) is a dermatological condition characterized by nodular hyperkeratotic lesions mainly on the legs and arms. Asymmetrical PN is a rare dermatological condition often associated with paralysis and stroke. In this paper, we present the case of a 77-year-old woman who developed post-ictal PN which responded to dupilumab, an anti-interleukin-4/13 drug approved for the management of AD, with an extreme reduction in itch sensation. Read More

Br J Dermatol 2022 May 23. Epub 2022 May 23.

Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

J Am Acad Dermatol 2022 May 13. Epub 2022 May 13.

Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts; Department of Dermatology, VA Integrated Service Network (VISN-1), Jamaica Plain, Massachusetts. Electronic address:

J Am Acad Dermatol 2022 May 13. Epub 2022 May 13.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Immunotargets Ther 2022 26;11:11-21. Epub 2022 Apr 26.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.

Prurigo nodularis is a chronic inflammatory skin disease consisting of severely pruritic nodules that can be very debilitating for patients. The basis of this skin condition is immunological dysregulation and neural amplification, driven by T-lymphocytes, mast cells, eosinophilic granulocytes, macrophages, and cytokines mediating itchy processes. Further complicating this already taxing diagnosis is the lack of approved treatment and consensus on management; although there are off-label treatments utilized as therapy. Read More

JAAD Int 2022 Jun 20;7:156-163. Epub 2022 Apr 20.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Introduction: Treating chronic pruritus is challenging for dermatologists due to the lack of therapeutic options. We review the effects of κ-opioid receptor (KOR) and μ-opioid receptor (MOR) in the modulation of itch, summarize evidence supporting the efficacy and safety of opioid receptor-targeting agents in chronic pruritus, and address clinical considerations.

Results: Preclinical studies have found neural pathways underlying detection, transmission, and modulation of itch signaling and spotlighted the importance of neuronal KOR and MOR in itch perception. Read More

Front Immunol 2022 12;13:885023. Epub 2022 Apr 12.

Department of Dermatology, Immunodermatology and Venereology, Medical University of Warsaw, Warsaw, Poland.

Pemphigoid nodularis is a rare form of pemphigoid that joins the clinical picture of prurigo nodularis and the immunological features of bullous pemphigoid, which is therapeutically challenging. Here, we analyze five female patients with a long-lasting course of nodular pemphigoid in terms of clinical and immunological characteristics and therapy. All the patients fulfilled clinical and immunological criteria of nodular pemphigoid. Read More

Actas Dermosifiliogr 2022 Jun 16;113(6):563-574. Epub 2021 Nov 16.

Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.

Chronic prurigo is itself a common condition, but it can also occur secondary to a large number of diseases. Management is challenging as historically chronic prurigo has been poorly defined and very few treatments are available. Clinically, it presents as excoriated, hyperkeratotic lesions. Read More

Ann Dermatol 2022 Apr 24;34(2):149-151. Epub 2022 Mar 24.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Dermatology 2022 Apr 13:1-11. Epub 2022 Apr 13.

Department of Dermatology and Venerology, Aarhus University Hospital, Aarhus, Denmark.

Background: Chronic nodular prurigo (CNPG) is a chronic, inflammatory skin disease, characterized by intense and debilitating pruritus. The pathophysiology is not fully understood, and the condition is difficult to treat with no targeted therapies. The aim of this systematic review was to review the evidence of therapies for non-atopic CNPG and conduct a meta-analysis of the results. Read More

Clin Cosmet Investig Dermatol 2022 21;15:503-506. Epub 2022 Mar 21.

Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.

Purpose: Despite recent advances in the treatment of prurigo nodularis, conventional treatment suffers from a dilemma of poor efficacy. The clinical use of Janus kinase (JAK) inhibitors in the treatment of Prurigo nodularis has rarely been explored.

Patients And Methods: We present a case of prurigo nodularis successfully treated with, JAK inhibitor tofacitinib with no adverse effects. Read More

J Allergy Clin Immunol Pract 2022 05 21;10(5):1365-1366. Epub 2022 Mar 21.

Internal Medicine Department, Centro Hospitalar Universitário do Porto, Porto, Portugal; Clinical Immunology Unity, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Actas Dermosifiliogr 2022 Mar 1;113(3):T244-T253. Epub 2021 Nov 1.

School of Biological Sciences & Medical Engineering, Southeast University, Nanjing, China; Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Nanjing, China; Institute of Child Development and Education, Southeast University, Nanjing, China. Electronic address:

Background: Prurigo nodularis (PN) as an extremely pruritic and hyperplastic chronic dermatosis induces psychologically and physiologically stressful responses. PN-induced responses in the hypothalamic-pituitary-adrenal, hypothalamic-pituitary-gonadal axes and endocannabinoid system are abnormal. Extant studies on the PN's pathogenesis mostly focused on the PN's psychological responses. Read More

Indian J Dermatol 2021 Nov-Dec;66(6):638-644

Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background: Prurigo nodularis (PN) is a chronic dermatologic condition presenting as multiple papulonodular lesions occurring with intense pruritus. Though numerous agents (topical, systemic, phototherapy and biological drugs) have been tried, the outcomes are variable.

Objectives: The aim of this study was to assess the role of topical and systemic therapies in primary PN by comparing the Pruritus Grading System (PGS) score at baseline and 1 month post-therapy. Read More

Indian J Dermatol 2021 Nov-Dec;66(6):685-687

School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, Jiangsu, China.

Indian J Dermatol 2021 Nov-Dec;66(6):609-615

Department of Dermatology, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, istanbul, Turkey.

Background: Melatonin is a hormone that regulates the sleep-wake cycle and has immunomodulatory and anti-inflammatory roles.

Aims: The aim of this study is to assess melatonin levels and investigate the association with pruritus severity, sleep quality, and depressive symptoms in dermatoses with nocturnal pruritus.

Methods: The study was a prospective study with 82 participants, including 41 patients and 41 healthy volunteers. Read More

Actas Dermosifiliogr 2022 Mar 8;113(3):244-253. Epub 2022 Feb 8.

School of Biological Sciences & Medical Engineering, Southeast University, Nanjing, China; Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Nanjing, China; Institute of Child Development and Education, Southeast University, Nanjing, China. Electronic address:

Background: Prurigo nodularis (PN) as an extremely pruritic and hyperplastic chronic dermatosis induces psychologically and physiologically stressful responses. PN-induced responses in the hypothalamic-pituitary-adrenal (HPA), hypothalamic-pituitary-gonadal (HPG) axes and endocannabinoid system (ECS) are abnormal. Extant studies on the PN's pathogenesis mostly focused on the PN's psychological responses. Read More

Ital J Dermatol Venerol 2022 Mar 11. Epub 2022 Mar 11.

Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy.

Chronic inflammatory skin diseases pose significant challenges for both patients and clinicians worldwide. Atopic dermatitis (AD), the most common of these diseases, affects up to 8% of the adult population depending on geographic location and demographic group, while prurigo nodularis (PN) is a less common disease that causes significant burden. In these inflammatory skin conditions, pruritus is a cardinal symptom. Read More

J Invest Dermatol 2022 Mar 4. Epub 2022 Mar 4.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:

J Dermatol 2022 06 21;49(6):e203-e205. Epub 2022 Feb 21.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

J Allergy Clin Immunol 2022 Apr 18;149(4):1213-1215. Epub 2022 Feb 18.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Solna, Sweden. Electronic address:

J Dermatol Sci 2022 Feb 4;105(2):130-136. Epub 2022 Feb 4.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Background: There are limited data characterizing the association between renal disease and prurigo nodularis (PN).

Objective: To characterize the association and describe mechanistic disease linkages between PN and renal comorbidities.

Methods: We conducted a cross-sectional analysis of renal comorbidities in PN using TriNetX, a global health research network providing access to medical records. Read More

JAMA Dermatol 2022 03;158(3):336

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Br J Dermatol 2022 Jan 26. Epub 2022 Jan 26.

Galderma SA, La Tour-de-Peilz, Switzerland.

Background: Prurigo nodularis is a debilitating skin condition that is classified as rare by the Genetic and Rare Diseases Information Center (GARD) and the National Organization for Rare Diseases (NORD). There are currently no estimates of the prevalence of prurigo nodularis in England.

Objectives: We aimed to address this data gap by describing the epidemiology of prurigo nodularis in a representative dataset derived from the English National Health Service. Read More