1,400 results match your criteria Prune Belly Syndrome


Food intake biomarkers for apple, pear, and stone fruit.

Genes Nutr 2018 29;13:29. Epub 2018 Nov 29.

2Human Nutrition Unit, Université Clermont Auvergne, INRA, F63000 Clermont-Ferrand, France.

Fruit is a key component of a healthy diet. However, it is still not clear whether some classes of fruit may be more beneficial than others and whether all individuals whatever their age, gender, health status, genotype, or gut microbiota composition respond in the same way to fruit consumption. Such questions require further observational and intervention studies in which the intake of a specific fruit can be precisely assessed at the population and individual levels. Read More

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November 2018

Clinical consequences of clonal hematopoiesis of indeterminate potential.

Authors:
David P Steensma

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):264-269

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

Clonally restricted hematopoiesis is a common aging-associated biological state that predisposes to subsequent development of a hematological malignancy or cardiovascular death. Clonal expansion driven by leukemia-associated somatic mutations, such as , , or , is best characterized, but oligoclonality can also emerge without recognized leukemia-driver mutations, perhaps as a result of stochastic neutral drift. Murine models provide compelling evidence that a major mechanism of increased cardiovascular mortality in the context of clonal hematopoiesis is accelerated atherogenesis driven by inflammasome-mediated endothelial injury, resulting from proinflammatory interactions between endothelium and macrophages derived from circulating clonal monocytes. Read More

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November 2018

Clinical consequences of clonal hematopoiesis of indeterminate potential.

Authors:
David P Steensma

Blood Adv 2018 Nov;2(22):3404-3410

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

Clonally restricted hematopoiesis is a common aging-associated biological state that predisposes to subsequent development of a hematological malignancy or cardiovascular death. Clonal expansion driven by leukemia-associated somatic mutations, such as , , or , is best characterized, but oligoclonality can also emerge without recognized leukemia-driver mutations, perhaps as a result of stochastic neutral drift. Murine models provide compelling evidence that a major mechanism of increased cardiovascular mortality in the context of clonal hematopoiesis is accelerated atherogenesis driven by inflammasome-mediated endothelial injury, resulting from proinflammatory interactions between endothelium and macrophages derived from circulating clonal monocytes. Read More

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November 2018

Stop, don't prune me!

Authors:
Darran Yates

Nat Rev Neurosci 2018 Dec;19(12):712-713

Nature Reviews Neuroscience, .

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December 2018

Direct contacts of microglia on myelin sheath and Ranvier's node in the corpus callosum in rats.

J Biomed Res 2018 Nov 5. Epub 2018 Nov 5.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Over the recent years, it has been found that microglia pseudopodia contact synapses, detect sick ones and prune them, even in adult animals. Myelinated nerves also carry out plasticity in which microglia remove myelin debris by phagocytosis. However, it remains unknown whether microglia explore structures on nerve fibers, such as Ranvier's node (RN) or myelin sheath, before they become debris. Read More

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November 2018

Faster Exact Computation of rSPR Distance via Better Approximation.

IEEE/ACM Trans Comput Biol Bioinform 2018 Oct 30. Epub 2018 Oct 30.

Due to hybridization events in evolution, studying two different genes of a set of species may yield two related but different phylogenetic trees for the set of species. In this case, we want to measure the dissimilarity of the two trees. The rooted subtree prune and regraft (rSPR) distance of the two trees has been used for this purpose. Read More

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October 2018

PLUG (Pruning of Local Unrealistic Geometries) removes restrictions on biophysical modeling for protein design.

Authors:
Mark A Hallen

Proteins 2018 Oct 31. Epub 2018 Oct 31.

Toyota Technological Institute at Chicago, Chicago, Illinois.

Protein design algorithms must search an enormous conformational space to identify favorable conformations. As a result, those that perform this search with guarantees of accuracy generally start with a conformational pruning step, such as dead-end elimination (DEE). However, the mathematical assumptions of DEE-based pruning algorithms have up to now severely restricted the biophysical model that can feasibly be used in protein design. Read More

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October 2018

Transitional Urology.

Urol Clin North Am 2018 Nov 7;45(4):601-610. Epub 2018 Sep 7.

Department of Urology, University College London Hospitals, 16-18 Westmoreland Street, London W1H 6PL, UK.

The field of transitional urology has taken on an increasing importance in recent years as more individuals with congenital urologic issues are living and thriving into adulthood. This article reviews the transitional process itself including barriers to successful transition and the consequences of failing to properly transition. Also provided is a broad overview of the urologic issues faced by patients who may benefit from lifelong care and the providers who will be helping them with transition and assuming their care. Read More

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November 2018
1 Read

Exploration of the fetus with gross anomaly: a case of pseudo prune belly syndrome.

Anat Cell Biol 2018 Sep 28;51(3):205-208. Epub 2018 Sep 28.

Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Prune belly syndrome is a rare congenital anomaly usually presented with triad characteristic feature of deficient abdominal muscles, cryptorchidism, and urinary tract anomalies. Here, we present a case with all the characteristic features of prune belly and the associated secondary features which were observed on detailed dissection and exploration of the fetus. Read More

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September 2018
1 Read

Nitrate-Rich Fruit and Vegetable Supplement Reduces Blood Pressure in Normotensive Healthy Young Males without Significantly Altering Flow-Mediated Vasodilation: A Randomized, Double-Blinded, Controlled Trial.

J Nutr Metab 2018 16;2018:1729653. Epub 2018 Sep 16.

Isagenix International LLC, Chandler, AZ, USA.

Nitric oxide (NO) is a primary vasodilatory factor released from endothelial cells of the peripheral vasculature. NO production is stimulated through enzymatic-dependent mechanisms via NO synthase and from dietary intake of nitrate-containing foods or supplements. We evaluated the efficacy of a nitrate-rich fruit and vegetable liquid supplement (FVS, AMPED NOx, Isagenix International LLC) versus a juice low in nitrates (prune juice, PRU) on circulating nitrates/nitrites as well as cardiovascular parameters in 45 healthy normotensive men (18-40 y). Read More

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September 2018

Copy number variations in a population with prune belly syndrome.

Am J Med Genet A 2018 Oct 4. Epub 2018 Oct 4.

University of Texas Southwestern Medical Center at Dallas, Children's Health, Center for Pediatric Urology, Dallas, TX.

Prune Belly Syndrome (PBS) is a congenital multisystem myopathy with mild to lethal severity. While of uncertain etiology, 95% male predominance and familial occurrence suggest a genetic basis. As copy number variations (CNVs) can cause unexplained genetic disorders, we tested for novel CNVs in a large PBS population. Read More

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October 2018
10 Reads

Inorganic Polyphosphate and Cancer.

Biochemistry (Mosc) 2018 Aug;83(8):961-968

Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.

This review presents data on the relationship between inorganic polyphosphate metabolism and carcinogenesis including participation of polyphosphates in the regulation of activity of mTOR and other proteins involved in carcinogenesis, the role of h-prune protein (human polyphosphatase) in cell migration and metastasis formation, the prospects for using polyphosphates and inhibitors of polyphosphate metabolism enzymes as agents for controlling cell proliferation and migration. Read More

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Living-related kidney transplantation with catheterizable urinary conduit in prune belly syndrome: A case report.

Int J Surg Case Rep 2018 19;51:150-153. Epub 2018 Aug 19.

Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

Introduction: Prune belly syndrome (PBS) presents with both renal dysplasia and urinary tract abnormalities. When performing kidney transplantation in PBS patients with kidney failure, extensive pretransplant urinary tract preparation may be necessary.

Presentation Of Case: We report the case of a 36-year-old man with PBS who underwent living-related kidney transplantation with urinary diversion using the Mitrofanoff principle. Read More

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August 2018
6 Reads

Ultrastructural Analysis of Intercellular Transport and Pathogenesis.

Int J Mol Sci 2018 Aug 29;19(9). Epub 2018 Aug 29.

Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA.

(PDV) is an important viral pathogen of plum, sweet cherry, peach, and many herbaceous test plants. Although PDV has been intensively investigated, mainly in the context of phylogenetic relationship of its genes and proteins, many gaps exist in our knowledge about the mechanism of intercellular transport of this virus. The aim of this work was to investigate alterations in cellular organelles and the cell-to-cell transport of PDV in cv. Read More

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August 2018
7 Reads

Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila.

PLoS Biol 2018 Aug 24;16(8):e2004506. Epub 2018 Aug 24.

Temasek Life Sciences Laboratory and Department of Biological Sciences, 1 Research Link, National University of Singapore, Singapore.

Refinement of the nervous system depends on selective removal of excessive axons/dendrites, a process known as pruning. Drosophila ddaC sensory neurons prune their larval dendrites via endo-lysosomal degradation of the L1-type cell adhesion molecule (L1-CAM), Neuroglian (Nrg). Here, we have identified a novel gene, pruning defect 1 (prd1), which governs dendrite pruning of ddaC neurons. Read More

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Path-planning with waiting in spatiotemporally-varying threat fields.

PLoS One 2018 23;13(8):e0202145. Epub 2018 Aug 23.

Aerospace Engineering Program, Worcester Polytechnic Institute, Worcester, MA, United States of America.

We address the problem of finding an optimal path for a vehicle in a planar environment where traversal costs are based on a time-varying spatial field defined over the environment. The resulting optimal path may contain instances of waiting, where the vehicle hovers, parks, or loiters. First, we consider path-planning on a uniform grid over the workspace. Read More

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Culling for Extreme-Scale Segmentation Volumes: A Hybrid Deterministic and Probabilistic Approach.

IEEE Trans Vis Comput Graph 2018 Aug 22. Epub 2018 Aug 22.

With the rapid increase in raw volume data sizes, such as terabyte-sized microscopy volumes, the corresponding segmentation label volumes have become extremely large as well. We focus on integer label data, whose efficient representation in memory, as well as fast random data access, pose an even greater challenge than the raw image data. Often, it is crucial to be able to rapidly identify which segments are located where, whether for empty space skipping for fast rendering, or for spatial proximity queries. Read More

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August 2018
9 Reads

Markov Boundary-Based Outlier Mining.

IEEE Trans Neural Netw Learn Syst 2018 Aug 20. Epub 2018 Aug 20.

It is a grand challenge to identify the outliers existing in subspaces from a high-dimensional data set. A brute-force method is computationally prohibitive since it requires examining an exponential number of subspaces. Current state-of-the-art methods explore various heuristics to significantly prune subspaces, facing the tradeoff between the subspace completeness and search efficiency. Read More

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EMA and FDA prune the checkpoint inhibitor treatment landscape.

Nat Rev Urol 2018 Oct;15(10):596-597

Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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October 2018
7 Reads

Phenotypic severity scoring system and categorisation for prune belly syndrome: application to a pilot cohort of 50 living patients.

BJU Int 2018 Aug 16. Epub 2018 Aug 16.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objective: To design a novel system of scoring prune belly syndrome (PBS) phenotypic severity at any presenting age and apply it to a large pilot cohort.

Patients And Methods: From 2000 to 2017, patients with PBS were recruited to our prospective PBS study and medical records were cross-sectionally analysed, generating individualised RUBACE scores. We designed the pragmatic RUBACE-scoring system based on six sub-scores (R: renal, U: ureter, B: bladder/outlet, A: abdominal wall, C: cryptorchidism, E: extra-genitourinary, generating the acronym RUBACE), yielding a potential summed score of 0-31. Read More

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August 2018
10 Reads

Prenatal renal parenchymal area as a predictor of early end-stage renal disease in children with vesicoamniotic shunting for lower urinary tract obstruction.

J Pediatr Urol 2018 Aug 24;14(4):320.e1-320.e6. Epub 2018 Jul 24.

Division of Pediatric Urology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, FL, USA.

Background: Vesicoamniotic shunting (VAS) and other bladder drainage techniques for fetal lower urinary tract obstruction (LUTO) have been proven to ameliorate pulmonary hypoplasia and increase survival in patients with an initial poor prognosis. Currently there are limited prognostic tools available during gestation to evaluate and predict postnatal renal function.

Objective: The aim was to describe the prenatal growth of the renal parenchymal area (RPA) in patients with LUTO and determine its application as a predictor of renal function at one year of life. Read More

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August 2018
2 Reads
1.410 Impact Factor

A new mechanical approach to handle generalized Hopfield neural networks.

Neural Netw 2018 Oct 21;106:205-222. Epub 2018 Jul 21.

Dipartimento di Matematica e Fisica Ennio De Giorgi, Università del Salento, Lecce, Italy; INFN, Istituto Nazionale di Fisica Nucleare, Sezione di Lecce, Italy. Electronic address:

We propose a modification of the cost function of the Hopfield model whose salient features shine in its Taylor expansion and result in more than pairwise interactions with alternate signs, suggesting a unified framework for handling both with deep learning and network pruning. In our analysis, we heavily rely on the Hamilton-Jacobi correspondence relating the statistical model with a mechanical system. In this picture, our model is nothing but the relativistic extension of the original Hopfield model (whose cost function is a quadratic form in the Mattis magnetization and mimics the non-relativistic counterpart, the so-called classical limit). Read More

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October 2018
2 Reads

Industrial prune processing and its effect on pesticide residue concentrations.

Food Chem 2018 Dec 19;268:264-270. Epub 2018 Jun 19.

Estación Experimental SIDAL, El Encanto 455 Dpto 203, Viña del Mar, Chile. Electronic address:

The aim of this study was to determine the insecticide residue processing factor (PF) from plums to prunes and the effect of the industrial processing of prunes residue concentrations. Our results show an increase of insecticide concentrations during plum dehydration that is explained by fruit water loss; however, the normalized insecticide residue concentration, based on plum dry weights to compensate dehydration, was reduced. The water washing and tenderizing of prunes produced insecticide residue reductions of 22. Read More

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December 2018

Management of Congenital Urethral Strictures In Infants. Case Series.

Urol J 2018 Jul 28. Epub 2018 Jul 28.

Paediatric Urology, University of Padova, Via Giustiniani 2, 35100 Padova, Italy.

Purpose: Infra-vesical obstruction is uncommon in infants and generally due to urethral valves. Congenital urethral strictures (CUS), instead, defined as a concentric narrowing of the urethral lumen, are exceedingly rare in infants.

Materials And Methods: We reviewed our experience with 7 patients treated at our institution for CUS Read More

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July 2018
2 Reads

ThiNet: Pruning CNN Filters for a Thinner Net.

IEEE Trans Pattern Anal Mach Intell 2018 Jul 20. Epub 2018 Jul 20.

This paper aims at accelerating and compressing deep neural networks to deploy CNN models into small devices like mobile phones or embedded gadgets. We focus on filter level pruning, i.e. Read More

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July 2018
11 Reads

SparkGIS: Resource Aware Efficient In-Memory Spatial Query Processing.

Proc ACM SIGSPATIAL Int Conf Adv Inf 2017 Nov;2017

Stony Brook University.

Much effort has been devoted to support high performance spatial queries on large volumes of spatial data in distributed spatial computing systems, especially in the MapReduce paradigm. Recent works have focused on extending spatial MapReduce frameworks to leverage high performance in-memory distributed processing capabilities of systems such as Spark. However, the performance advantage comes with the requirement of having enough memory and comprehensive configuration. Read More

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November 2017

Vesicoamniotic Shunting Improves Outcomes in a Subset of Prune Belly Syndrome Patients at a Single Tertiary Center.

Front Pediatr 2018 3;6:180. Epub 2018 Jul 3.

Scott Department of Urology, Baylor College of Medicine, Houston, TX, United States.

Review outcomes of Prune Belly Syndrome (PBS) with the hypothesis that contemporary management improves mortality. A retrospective chart review of inpatient and outpatient PBS patients referred between 2000 and 2018 was conducted to assess outcomes at our institution. Data collected included age at diagnosis, concomitant medical conditions, imaging, operative management, length of follow-up, and renal function. Read More

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July 2018
2 Reads

Structure Optimization for Large Gene Networks Based on Greedy Strategy.

Comput Math Methods Med 2018 14;2018:9674108. Epub 2018 Jun 14.

Carrera de Ingeniería Informática, Universidad Americana, Asunción, Paraguay.

In the last few years, gene networks have become one of most important tools to model biological processes. Among other utilities, these networks visually show biological relationships between genes. However, due to the large amount of the currently generated genetic data, their size has grown to the point of being unmanageable. Read More

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Calculating the Unrooted Subtree Prune-and-Regraft Distance.

IEEE/ACM Trans Comput Biol Bioinform 2018 Feb 14. Epub 2018 Feb 14.

The subtree prune-and-regraft (SPR) distance metric is a fundamental way of comparing evolutionary trees. It has wide-ranging applications, such as to study lateral genetic transfer, viral recombination, and Markov chain Monte Carlo phylogenetic inference. Although the rooted version of SPR distance can be computed relatively efficiently between rooted trees using fixed-parameter-tractable maximum agreement forest (MAF) algorithms, no MAF formulation is known for the unrooted case. Read More

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February 2018
3 Reads

Bayesian validation of grammar productions for the language of thought.

PLoS One 2018 10;13(7):e0200420. Epub 2018 Jul 10.

Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Buenos Aires, Argentina.

Probabilistic proposals of Language of Thoughts (LoTs) can explain learning across different domains as statistical inference over a compositionally structured hypothesis space. While frameworks may differ on how a LoT may be implemented computationally, they all share the property that they are built from a set of atomic symbols and rules by which these symbols can be combined. In this work we propose an extra validation step for the set of atomic productions defined by the experimenter. Read More

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July 2018
17 Reads

Adjuvant anti-angiogenic therapy enhances chemotherapeutic uptake in a murine model of head and neck cancer.

J Drug Target 2018 Aug 20:1-8. Epub 2018 Aug 20.

c Department of Otolaryngology , University of Alabama at Birmingham , Birmingham , AL , USA.

Intratumoural metabolic demands result in excessive angiogenic cytokine release leading to unorganised vasculature. Resultant fluid dynamics oppose blood flow and drug penetration due to a marked increase in interstitial fluid hydrostatic pressure. It is hypothesised that anti-angiogenic therapy may function to 'prune' vasculature and lead to improved chemotherapeutic penetration. Read More

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August 2018
8 Reads

Late-Season Shiraz Berry Dehydration That Alters Composition and Sensory Traits of Wine.

J Agric Food Chem 2018 Jul 17;66(29):7750-7757. Epub 2018 Jul 17.

The Australian Research Council Training Centre for Innovative Wine Production , The University of Adelaide , Glen Osmond , South Australia 5064 , Australia.

Late-season berry dehydration (LSD) is a common occurrence in Shiraz grapes, particularly those grown in hot climates. LSD results in significant yield reductions; however, the effects on wine composition and sensory characteristics are not well-documented. Wines made of 100% nonshriveled clusters (control) were related to red fruit flavors by the sensory panel, whereas wines made of 80% shriveled clusters (S-VCT) were perceived as more alcoholic and associated with dark fruit and dead/stewed fruit characters. Read More

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July 2018
8 Reads

Exploring the Tiers of Rooted Phylogenetic Network Space Using Tail Moves.

Bull Math Biol 2018 Aug 14;80(8):2177-2208. Epub 2018 Jun 14.

Institut des Sciences de l'Evolution, CNRS, IRD, EPHE, Université de Montpellier, Place Eugène Bataillon, Montpellier, France.

Popular methods for exploring the space of rooted phylogenetic trees use rearrangement moves such as rooted Nearest Neighbour Interchange (rNNI) and rooted Subtree Prune and Regraft (rSPR). Recently, these moves were generalized to rooted phylogenetic networks, which are a more suitable representation of reticulate evolutionary histories, and it was shown that any two rooted phylogenetic networks of the same complexity are connected by a sequence of either rSPR or rNNI moves. Here, we show that this is possible using only tail moves, which are a restricted version of rSPR moves on networks that are more closely related to rSPR moves on trees. Read More

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August 2018
18 Reads

SNPrune: an efficient algorithm to prune large SNP array and sequence datasets based on high linkage disequilibrium.

Genet Sel Evol 2018 06 26;50(1):34. Epub 2018 Jun 26.

Animal Breeding and Genomics, Wageningen University & Research, P.O. Box 338, 6700 AH, Wageningen, The Netherlands.

Background: High levels of pairwise linkage disequilibrium (LD) in single nucleotide polymorphism (SNP) array or whole-genome sequence data may affect both performance and efficiency of genomic prediction models. Thus, this warrants pruning of genotyping data for high LD. We developed an algorithm, named SNPrune, which enables the rapid detection of any pair of SNPs in complete or high LD throughout the genome. Read More

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Translation Synchronization via Truncated Least Squares.

Adv Neural Inf Process Syst 2017 Dec;30:1459-1468

The University of Texas at Austin, 2317 Speedway, Austin, 78712.

In this paper, we introduce a robust algorithm, , for the 1D translation synchronization problem, in which the aim is to recover the global coordinates of a set of nodes from noisy measurements of relative coordinates along an observation graph. The basic idea of TranSync is to apply truncated least squares, where the solution at each step is used to gradually prune out noisy measurements. We analyze TranSync under both deterministic and randomized noisy models, demonstrating its robustness and stability. Read More

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December 2017

Collagen I and III in women with diastasis recti.

Clinics (Sao Paulo) 2018 06 7;73:e319. Epub 2018 Jun 7.

Servico de Cirurgia Digestiva, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, RS, BR.

Objectives: Interest in elucidating the etiology of hernias has encouraged countless studies of musculoaponeurotic structures in individuals with and without hernias. Studies of hernia patients have firmly demonstrated a correlation between hernias and collagen alterations in their fascia. Diastasis recti is an increased width of the abdominal midline that is exclusively composed of interlacing aponeurotic expansions of the anterolateral abdominal muscles. Read More

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June 2018
3 Reads

Synapse Pruning: Mitochondrial ROS with Their Hands on the Shears.

Authors:
James N Cobley

Bioessays 2018 Jul 4;40(7):e1800031. Epub 2018 Jun 4.

Free Radical Research Group, Centre for Health Science, University of the Highlands and Islands, Old Perth Road,Inverness, IV2 3JH, UK.

No overarching hypotheses tie the basic mechanisms of mitochondrial reactive oxygen species (ROS) production to activity dependent synapse pruning-a fundamental biological process in health and disease. Neuronal activity divergently regulates mitochondrial ROS: activity decreases whereas inactivity increases their production, respectively. Placing mitochondrial ROS as innate synaptic activity sentinels informs the novel hypothesis that: (1) at an inactive synapse, increased mitochondrial ROS production initiates intrinsic apoptosis dependent pruning; and (2) at an active synapse, decreased mitochondrial ROS production masks intrinsic apoptosis dependent pruning. Read More

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July 2018
1 Read

Volatile and sensory profiling of Shiraz wine in response to alcohol management: comparison of harvest timing versus technological approaches.

Food Res Int 2018 Jul 27;109:561-571. Epub 2018 Apr 27.

National Wine and Grape Industry Centre, Charles Sturt University, Wagga Wagga, NSW 2678, Australia; School of Agricultural and Wine Sciences, Charles Sturt University, Wagga Wagga, Australia; Australian Research Council-Training Centre for Innovative Wine Production, University of Adelaide, Glen Osmond, SA 5064, Australia.

The aim of this study was to compare the volatile and sensory profiles of Australian Shiraz red wines produced by several methods to achieve alcohol concentrations of 10.5 and 13.5% v/v. Read More

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Temporal transcriptional logic of dynamic regulatory networks underlying nitrogen signaling and use in plants.

Proc Natl Acad Sci U S A 2018 06 16;115(25):6494-6499. Epub 2018 May 16.

Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003;

This study exploits time, the relatively unexplored fourth dimension of gene regulatory networks (GRNs), to learn the temporal transcriptional logic underlying dynamic nitrogen (N) signaling in plants. Our "just-in-time" analysis of time-series transcriptome data uncovered a temporal cascade of elements underlying dynamic N signaling. To infer transcription factor (TF)-target edges in a GRN, we applied a time-based machine learning method to 2,174 dynamic N-responsive genes. Read More

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June 2018
1 Read

Yif1 associates with Yip1 on Golgi and regulates dendrite pruning in sensory neurons during metamorphosis.

Development 2018 06 13;145(12). Epub 2018 Jun 13.

Temasek Life Sciences Laboratory and Department of Biological Sciences, 1 Research Link, National University of Singapore, Singapore 117604

Pruning that selectively removes unnecessary neurites without causing neuronal death is essential for sculpting the mature nervous system during development. In , ddaC sensory neurons specifically prune their larval dendrites with intact axons during metamorphosis. However, the important role of endoplasmic reticulum (ER)-to-Golgi transport in dendrite pruning remains unknown. Read More

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Spatial regulation of microtubule disruption during dendrite pruning in .

Development 2018 05 11;145(9). Epub 2018 May 11.

Institute for Neurobiology, University of Münster, Badestrasse 9, 48149 Münster, Germany

Large-scale neurite pruning is an important specificity mechanism during neuronal morphogenesis. sensory neurons prune their larval dendrites during metamorphosis. Pruning dendrites are severed in their proximal regions, but how this spatial information is encoded is not clear. Read More

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Microglial Pruning of Synapses in the Prefrontal Cortex During Adolescence.

Cereb Cortex 2018 Apr 13. Epub 2018 Apr 13.

Neuroscience Program, Vanderbilt University, Nashville, TN 37240, USA.

Exaggerated synaptic elimination in the prefrontal cortex (PFC) during adolescence has been suggested to contribute to the neuropathological changes of schizophrenia. Recent data indicate that microglia (MG) sculpt synapses during early postnatal development. However, it is not known if MG contribute to the structural maturation of the PFC, which has a protracted postnatal development. Read More

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April 2018
1 Read

A novel decision tree classification based on post-pruning with Bayes minimum risk.

PLoS One 2018 4;13(4):e0194168. Epub 2018 Apr 4.

Department of Information Technology, School of Computing and Technology, Eastern Mediterranean University, Gazimağusa / North Cyprus, TURKEY.

Pruning is applied in order to combat over-fitting problem where the tree is pruned back with the goal of identifying decision tree with the lowest error rate on previously unobserved instances, breaking ties in favour of smaller trees with high accuracy. In this paper, pruning with Bayes minimum risk is introduced for estimating the risk-rate. This method proceeds in a bottom-up fashion converting a parent node of a subtree to a leaf node if the estimated risk-rate of the parent node for that subtree is less than the risk-rates of its leaf. Read More

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July 2018
1 Read

Evolutionary pruning of transfer learned deep convolutional neural network for breast cancer diagnosis in digital breast tomosynthesis.

Phys Med Biol 2018 May 1;63(9):095005. Epub 2018 May 1.

Department of Radiology, University of Michigan, Ann Arbor, MI 48109-5842, United States of America.

Deep learning models are highly parameterized, resulting in difficulty in inference and transfer learning for image recognition tasks. In this work, we propose a layered pathway evolution method to compress a deep convolutional neural network (DCNN) for classification of masses in digital breast tomosynthesis (DBT). The objective is to prune the number of tunable parameters while preserving the classification accuracy. Read More

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May 2018
2 Reads

Precursors of logical reasoning in preverbal human infants.

Science 2018 03;359(6381):1263-1266

ICREA (Catalan Institution for Research and Advanced Studies), Pg. Lluís Companys 23, 08010 Barcelona, Spain.

Infants are able to entertain hypotheses about complex events and to modify them rationally when faced with inconsistent evidence. These capacities suggest that infants can use elementary logical representations to frame and prune hypotheses. By presenting scenes containing ambiguities about the identity of an object, here we show that 12- and 19-month-old infants look longer at outcomes that are inconsistent with a logical inference necessary to resolve such ambiguities. Read More

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March 2018
1 Read

The Incidence and Genetic Diversity of Apple Mosaic Virus (ApMV) and Prune Dwarf Virus (PDV) in Prunus Species in Australia.

Viruses 2018 03 19;10(3). Epub 2018 Mar 19.

Agriculture Victoria, AgriBio, La Trobe University, Melbourne VIC 3083, Australia.

Apple mosaic virus (ApMV) and prune dwarf virus (PDV) are amongst the most common viruses infecting species worldwide but their incidence and genetic diversity in Australia is not known. In a survey of 127 tree samples collected from five states in Australia, ApMV and PDV occurred in 4 (3%) and 13 (10%) of the trees respectively. High-throughput sequencing (HTS) of amplicons from partial conserved regions of RNA1, RNA2, and RNA3, encoding the methyltransferase (MT), RNA-dependent RNA polymerase (RdRp), and the coat protein (CP) genes respectively, of ApMV and PDV was used to determine the genetic diversity of the Australian isolates of each virus. Read More

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March 2018
4 Reads

The Health Halo Trend in UK Television Food Advertising Viewed by Children: The Rise of Implicit and Explicit Health Messaging in the Promotion of Unhealthy Foods.

Int J Environ Res Public Health 2018 03 20;15(3). Epub 2018 Mar 20.

Department of Psychological Sciences, University of Liverpool, Liverpool L69 7ZX, UK.

Monitoring the creative content within food marketing to children is strongly advocated by public health authorities, but few studies address the prevalence of health-related messaging in television adverts. Food and beverage adverts ( = 18,888 in 2008, = 6664 in 2010) from UK television channels popular with children were coded and analyzed. Physical-activity depiction displayed an 18. Read More

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March 2018
3 Reads

Diastasis recti abdominis - a review of treatment methods.

Ginekol Pol 2018 ;89(2):97-101

Institute of Physiotherapy, Jan Kochanowski University in Kielce, Kielce, Poland.

Diastasis recti abdominis is a condition in which both rectus abdominis muscles disintegrate to the sides, this being ac-companied by the extension of the linea alba tissue and bulging of the abdominal wall. DRA may result in the herniation of the abdominal viscera, but it is not a hernia per se. DRA is common in the female population during pregnancy and in the postpartum period. Read More

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July 2018
17 Reads

Three cases of prune belly syndrome at the Lagos State University Teaching Hospital, Ikeja.

Saudi J Kidney Dis Transpl 2018 Jan-Feb;29(1):178-184

Department of Pediatrics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.

Prune belly syndrome (PBS) is a rare congenital disorder affecting 2.5 to 3.8/100,000 live births worldwide. Read More

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February 2018
9 Reads