720 results match your criteria Providencia Infections


Anthocyanins in Blueberries Grown in Hot Climate Exert Strong Antioxidant Activity and May Be Effective against Urinary Tract Bacteria.

Antioxidants (Basel) 2020 Jun 2;9(6). Epub 2020 Jun 2.

Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C/Profesor García González 2, 41012 Sevilla, Spain.

Anthocyanins are extensively studied for their health-related properties, including antibacterial activity against urinary tract infections (UTI). Among common fruits, blueberries, with their remarkable antioxidant capacity, are one of the richest sources. Anthocyanin-rich extracts were obtained from four varieties: Snowchaser, Star, Stella Blue and Cristina Blue, grown in the hot climate of Southern Spain. Read More

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http://dx.doi.org/10.3390/antiox9060478DOI Listing

Transposon Insertion Site Sequencing of Providencia stuartii: Essential Genes, Fitness Factors for Catheter-Associated Urinary Tract Infection, and the Impact of Polymicrobial Infection on Fitness Requirements.

mSphere 2020 May 27;5(3). Epub 2020 May 27.

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA

is a common cause of polymicrobial catheter-associated urinary tract infection (CAUTI), and yet literature describing the molecular mechanisms of its pathogenesis is limited. To identify factors important for colonization during single-species infection and during polymicrobial infection with a common cocolonizer, , we created a saturating library of ∼50,000 transposon mutants and conducted transposon insertion site sequencing (Tn-Seq) in a murine model of CAUTI. strain BE2467 carries 4,398 genes, 521 of which were identified as essential for growth in laboratory medium and therefore could not be assessed for contribution to infection. Read More

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http://dx.doi.org/10.1128/mSphere.00412-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253602PMC

A Tailspike with Exopolysaccharide Depolymerase Activity from a New Providencia stuartii Phage Makes Multidrug-Resistant Bacteria Susceptible to Serum-Mediated Killing.

Appl Environ Microbiol 2020 Jun 17;86(13). Epub 2020 Jun 17.

CEB-Centre of Biological Engineering, University of Minho, Braga, Portugal

is emerging as a significant drug-resistant nosocomial pathogen, which encourages the search for alternative therapies. Here, we have isolated phage Stuart, a novel podovirus infecting multidrug-resistant hospital isolates of this bacterium. Phage Stuart is a proposed member of a new subfamily genus, with a 41,218-bp genome, direct 345-bp repeats at virion DNA ends, and limited sequence similarity of proteins to proteins in databases. Read More

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http://dx.doi.org/10.1128/AEM.00073-20DOI Listing

Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene (X)-Bearing Plasmidome among Bacteria.

mSystems 2020 Apr 28;5(2). Epub 2020 Apr 28.

College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People's Republic of China

The emergence of novel plasmid-mediated resistance genes constitutes a great public concern. Recently, mobile (X) variants were reported in diverse pathogens from different sources. However, the diversity of (X)-bearing plasmids remains largely unknown. Read More

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http://dx.doi.org/10.1128/mSystems.00134-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190383PMC

Antimicrobial susceptibility and distribution of extended-spectrum β-lactamases, AmpC β-lactamases, and carbapenemases among Proteus, Providencia, and Morganella isolated from global hospitalized patients with intra-abdominal and urinary tract infections: Results of the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2008-2011.

J Glob Antimicrob Resist 2020 Apr 17. Epub 2020 Apr 17.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Background: The increasing trend of β-lactam resistance among Enterobacteriaceae is a worldwide problem. In this study, we investigated isolates of the tribe Proteeae (Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Providencia rettgeri, and Morganella morganii) causing intra-abdominal infections and urinary tract infections from the worldwide Study for Monitoring Antimicrobial Resistance Trends collected from 2008 to 2011.

Methods: Antimicrobial susceptibility testing was performed in isolates with an ertapenem minimum inhibitory concentration>0. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.04.011DOI Listing

COVID-19: Initial experience of an international group of hand surgeons.

Hand Surg Rehabil 2020 05 9;39(3):159-166. Epub 2020 Apr 9.

Icube CNRS 7357, department of hand surgery, hôpital de Hautepierre, university hospital of Strasbourg, FMTS, university of Strasbourg, 1, avenue Molière, 67200 Strasbourg cedex, France. Electronic address:

The emergence of the COVID-19 pandemic has severely affected medical treatment protocols throughout the world. While the pandemic does not affect hand surgeons at first glance, they have a role to play. The purpose of this study was to describe the different measures that have been put in place in response to the COVID-19 pandemic by hand surgeons throughout the world. Read More

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http://dx.doi.org/10.1016/j.hansur.2020.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194873PMC

Characterization of Resistance in Gram-Negative Urinary Isolates Using Existing and Novel Indicators of Clinical Relevance: A 10-Year Data Analysis.

Life (Basel) 2020 Feb 11;10(2). Epub 2020 Feb 11.

Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, 6725 Szeged, Semmelweis utca 6., Hungary.

Classical resistance classifications (multidrug resistance [MDR], extensive drug resistance [XDR], pan-drug resistance [PDR]) are very useful for epidemiological purposes, however, they may not correlate well with clinical outcomes, therefore, several novel classification criteria (e.g., usual drug resistance [UDR], difficult-to-treat resistance [DTR]) were introduced for Gram-negative bacteria in recent years. Read More

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http://dx.doi.org/10.3390/life10020016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175163PMC
February 2020

Occurrence and Characteristics of Mobile Colistin Resistance () Gene-Containing Isolates from the Environment: A Review.

Int J Environ Res Public Health 2020 02 6;17(3). Epub 2020 Feb 6.

Department of Veterinary Public Health and Preventive Medicine, University of Nigeria, Nsukka 400001, Nigeria.

The emergence and spread of mobile colistin (COL) resistance () genes jeopardize the efficacy of COL, a last resort antibiotic for treating deadly infections. COL has been used in livestock for decades globally. Bacteria have mobilized genes (-1 to -9). Read More

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http://dx.doi.org/10.3390/ijerph17031028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036836PMC
February 2020
2.063 Impact Factor

Isolation of Morganella morganii and Providencia species from clinical samples in a tertiary care hospital.

Infect Disord Drug Targets 2020 Jan 28. Epub 2020 Jan 28.

Department of Microbiology, Government Medical College Hospital, Chandigarh, India.

Introduction: The members of the tribe Proteeae, Morganella and Providencia are being increasingly recognized as important pathogens. The spectrum of disease caused by them is wide and in reported cases the mortality is high. Previously both these pathogens were considered to be rare pathogens as the potential to cause nosocomial transmission and infection was not much studied. Read More

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http://dx.doi.org/10.2174/1871526520666200128162646DOI Listing
January 2020

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design.

Front Immunol 2019 29;10:2806. Epub 2019 Nov 29.

Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorganisms other than , such as and . Innate immune cells, including monocytes and natural killer (NK) cells, contribute to this non-specific immune protection in a way that is independent of memory T or B cells. Read More

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http://dx.doi.org/10.3389/fimmu.2019.02806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896902PMC
November 2019

Outcomes of treating AmpC-producing Enterobacterales bacteraemia with carbapenems vs. non-carbapenems.

Int J Antimicrob Agents 2020 Feb 11;55(2):105860. Epub 2019 Dec 11.

Tan Tock Seng Hospital, Singapore, Singapore; National Centre for Infectious Diseases, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Introduction: AmpC β-lactamases are found in Enterobacter species, Serratia species, Citrobacter freundii, Providencia species and Morganella morganii ('ESCPM'). Carbapenems are commonly used to treat severe 'ESCPM' infections. Carbapenem-sparing agents are needed because of increasing carbapenem resistance worldwide. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.105860DOI Listing
February 2020

[Purple Urine Bag Syndrome: A Rare Clinical Case].

Mikrobiyol Bul 2019 Oct;53(4):457-463

Health Science University, Ankara Training and Research Hospital, Department of Medical Microbiology, Ankara, Turkey.

Purple urine bag syndrome (PUBS) is a rare syndrome characterized by production of indigo (blue) and indirubin (red) pigments due to bacterial colonization in urinary catheter. The pathogenesis of PUBS is related to the combination of these two pigments produced from the metabolism of tryptophan. Tryptophan turns into indole by deamination, indole turns into indoxyl sulphate by hepatic conjugation and indoxyl sulphate is secreted into urine. Read More

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http://dx.doi.org/10.5578/mb.68616DOI Listing
October 2019

Infections caused by naturally AmpC-producing Enterobacteriaceae: Can we use third-generation cephalosporins? A narrative review.

Int J Antimicrob Agents 2020 Feb 1;55(2):105834. Epub 2019 Nov 1.

Laboratoire Bactériologie-Virologie-Hygiène, Hôpital Avicenne, Université Paris 13, 93000 Bobigny, France; UMR 1137 IAME, INSERM, Université Paris 13, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

The burden of antibiotic-resistant infections among Gram-negative bacteria is increasing. Resistance to third-generation cephalosporins (3GCs) in Enterobacteriaceae is mainly conferred by the acquisition of β-lactamases or by deregulation of natural genetically-encoded β-lactamase enzymes. Enterobacteriaceae such as Enterobacter spp. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.10.015DOI Listing
February 2020

Consequences of chronic bacterial infection in Drosophila melanogaster.

PLoS One 2019 24;14(10):e0224440. Epub 2019 Oct 24.

Department of Entomology, Cornell University, Ithaca, New York, United States of America.

Even when successfully surviving an infection, a host often fails to eliminate a pathogen completely and may sustain substantial pathogen burden for the remainder of its life. Using systemic bacterial infection in Drosophila melanogaster, we characterize chronic infection by three bacterial species from different genera - Providencia rettgeri, Serratia marcescens, and Enterococcus faecalis-following inoculation with a range of doses. To assess the consequences of these chronic infections, we determined the expression of antimicrobial peptide genes, survival of secondary infection, and starvation resistance after one week of infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812774PMC

Detection of Pan drug resistance OXA-48 producing Providencia in an ICU patient for the first time in Nepal.

Antimicrob Resist Infect Control 2019 15;8:155. Epub 2019 Oct 15.

IDI-IRI, Ankara, Turkey.

Background: Resistance to antimicrobial agents of pathogenic bacteria has become a major problem in routine medical practices. Carbapenem resistance has long been increasing. The production of carbapenem- hydrolysing β-lactamases (carbapenamases), which include NDM, KPC, OXA-48, IMP-1 and VIM is the most common mechanism. Read More

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http://dx.doi.org/10.1186/s13756-019-0608-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794824PMC
June 2020
2 Reads

Genetic analysis of carbapenemase-producing Gram-negative bacteria isolated from a university teaching hospital in Egypt.

Infect Genet Evol 2020 01 18;77:104065. Epub 2019 Oct 18.

Laboratory of Food Microbiology and Hygiene, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8528, Japan. Electronic address:

A total of 65 non-replicate Gram-negative bacterial strains were recovered from clinical specimens between April and September 2014 at a University Hospital in Egypt. This collection was screened by PCR for carbapenemase-encoding genes, 16S rRNA methylases, and colistin resistance genes (mcr-1-mcr-8). Twenty-two strains (22/65, 33. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.104065DOI Listing
January 2020
2 Reads
3.015 Impact Factor

A Rare Opportunist, , Decreases Severity of Polymicrobial Catheter-Associated Urinary Tract Infection.

Infect Immun 2019 12 17;88(1). Epub 2019 Dec 17.

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA

Catheter-associated urinary tract infections (CAUTIs) are common hospital-acquired infections and frequently polymicrobial, which complicates effective treatment. However, few studies experimentally address the consequences of polymicrobial interactions within the urinary tract, and the clinical significance of polymicrobial bacteriuria is not fully understood. is one of the most common causes of monomicrobial and polymicrobial CAUTI and frequently cocolonizes with , , , and infections are particularly challenging due to its potent urease enzyme, which facilitates formation of struvite crystals, catheter encrustation, blockage, and formation of urinary stones. Read More

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http://dx.doi.org/10.1128/IAI.00691-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921659PMC
December 2019
1 Read

Identification of volatile biomarkers of Giardia duodenalis infection in children with persistent diarrhoea.

Parasitol Res 2019 Nov 12;118(11):3139-3147. Epub 2019 Oct 12.

Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, 41012, Seville, Spain.

Currently, chronic diarrhoea syndrome in children is a very common pathology whose aetiology is sometimes difficult to identify. Methodologies for the diagnosis of infections have diversified, and gas chromatography/mass spectrometry (GC/MS) is a very useful tool. The aim of this study was to identify volatile biomarkers of the presence of Giardia duodenalis in the faeces of patients with chronic diarrhoea (with and without giardiasis) using static headspace extraction followed by GC/MS. Read More

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http://dx.doi.org/10.1007/s00436-019-06433-4DOI Listing
November 2019
2 Reads

Susceptibility evolution to antibiotics of Enterobacter cloacae, Morganella morganii, Klebsiella aerogenes and Citrobacter freundii involved in urinary tract infections: an 11-year epidemiological surveillance study.

Enferm Infecc Microbiol Clin 2020 Apr 10;38(4):166-169. Epub 2019 Oct 10.

Departamento de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Sanitaria-Granada, Granada, España; Departamento de Microbiología, Facultad de Medicina, Universidad de Granada, Instituto de Investigación Sanitaria-Granada, Granada, España. Electronic address:

Introduction: The objective of this study was to analyse the susceptibility to antibiotic of Citrobacter freundii, Klebsiella aerogenes, Enterobacter cloacae, Serratia marcescens, Providencia stuartii and Morganella morganii (CESPM group), detected in urine cultures.

Methods: Between 2006 and 2016 we analyzed CESPM group Enterobacteria isolated from urine cultures from both primary health-care centers and Hospital Virgen de las Nieves (Granada). We studied the susceptibility to aminoglycosides, fosfomycin, nitrofurantoin, quinolones, piperacillin/tazobactam, cefepime, imipenem and trimethoprim/sulfamethoxazole following CLSI interpretation criteria. Read More

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http://dx.doi.org/10.1016/j.eimc.2019.07.010DOI Listing
April 2020
1 Read
1.881 Impact Factor

Lemierre's syndrome: a possible cause of neck pain.

Intern Emerg Med 2019 11 18;14(8):1339-1340. Epub 2019 Sep 18.

Department of Emergency Medicine, Chi-Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan, 710, Taiwan.

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http://dx.doi.org/10.1007/s11739-019-02194-1DOI Listing
November 2019
1 Read
2.624 Impact Factor

High prevalence of multiple drug resistant enteric bacteria: Evidence from a teaching hospital in Southwest Nigeria.

J Infect Public Health 2020 Apr 13;13(4):651-656. Epub 2019 Sep 13.

Department of Biological Science, Redeemers University, Ede, Nigeria.

The development and evolution of antimicrobial resistance (AMR) in pathogens has been reported to be one of the major issues confronting the global health community. The aim of this study was to examine the period prevalence of antibiotic resistance, as well as the trends and patterns in sensitivity profile of enteric bacteria isolated from urine samples of patients with UTIs in a teaching Hospital in south west Nigeria. Urine samples were collected from 77 patients with UTIs from February 2017 to October 2018. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.08.014DOI Listing
April 2020
2 Reads

Plasmid evolution in carbapenemase-producing Enterobacteriaceae: a review.

Ann N Y Acad Sci 2019 12 30;1457(1):61-91. Epub 2019 Aug 30.

Department of Medical Microbiology, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, Gauteng, South Africa.

Carbapenem-resistant Enterobacteriaceae (CRE) have been listed by the WHO as high-priority pathogens owing to their high association with mortalities and morbidities. Resistance to multiple β-lactams complicates effective clinical management of CRE infections. Using plasmid typing methods, a wide distribution of plasmid replicon groups has been reported in CREs around the world, including IncF, N, X, A/C, L/M, R, P, H, I, and W. Read More

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http://dx.doi.org/10.1111/nyas.14223DOI Listing
December 2019
4.313 Impact Factor

Impact assessment and investigation of factors associated with herpesviruses viremia in the first year of renal transplantation.

J Med Virol 2020 01 5;92(1):107-112. Epub 2019 Sep 5.

Department of Microbiology and Parasitology, Biomedical Institute, Fluminense Federal University, Niteroi, Brazil.

The increased risk for opportunistic infections after a renal transplant requires monitoring of viral infections to avoid future complications. Our goal was to investigate the impact and factors associated with Epstein-Barr virus (EBV), human cytomegalovirus (HCMV) and human herpesvirus type 6 (HHV-6) viremia in renal transplant recipients. Whole blood samples were collected monthly from 82 patients during the first semester and then quarterly up to 1 year after transplantation. Read More

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http://dx.doi.org/10.1002/jmv.25580DOI Listing
January 2020
3 Reads

Bacteria Detected in both Urine and Open Wounds in Nursing Home Residents: a Pilot Study.

mSphere 2019 08 28;4(4). Epub 2019 Aug 28.

Center for Clinical Management Research, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA

Nursing home residents are at a greater risk of developing pressure injuries that develop into an open wound, which can become colonized with bacteria. Understanding the factors that influence microbial colonization of open wounds can lead to the prevention of infections. The relationship between bacteria found in urine and those in open wounds is currently unknown. Read More

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http://dx.doi.org/10.1128/mSphere.00463-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714893PMC
August 2019
4 Reads

Nitroxoline: a potent antimicrobial agent against multidrug resistant Enterobacteriaceae.

EXCLI J 2019 26;18:445-453. Epub 2019 Jun 26.

Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and antineurodegenerative activities. Read More

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http://dx.doi.org/10.17179/excli2019-1378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694710PMC
June 2019
2 Reads

A prospective randomized comparative study of targeted versus empirical prophylactic antibiotics in the prevention of infective complications following transrectal ultrasound-guided prostate biopsy.

Ann Afr Med 2019 Jul-Sep;18(3):132-137

Urology Division, Department of Surgery, Lagos State University Teaching Hospital; Urology Division, Department of Surgery, Lagos State University College of Medicine, Lagos, Nigeria.

Background: It is established that antibiotic prophylaxis prevents infection following transrectal ultrasound-guided prostate biopsy. This study compares the infective complications in transrectal prostate biopsy (TRPB) in empirical versus targeted prophylactic antibiotics.

Patients And Methods: Urine and rectal swabs were obtained prior to TRPB. Read More

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http://dx.doi.org/10.4103/aam.aam_48_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704807PMC
February 2020
3 Reads

High prevalence and diversity of extended-spectrum β-lactamase and emergence of OXA-48 producing Enterobacterales in wildlife in Catalonia.

PLoS One 2019 5;14(8):e0210686. Epub 2019 Aug 5.

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

Most of the studies focused on antimicrobial resistance (AMR) performed in wildlife describe Escherichia coli as the principal indicator of the selective pressure. In the present study, several species of Enterobacterales with a large panel of cephalosporin resistant (CR) genes have been isolated from wildlife in Catalonia. A total of 307 wild animals were examined to determine the prevalence of CR enterobacteria, AMR phenotypes and the presence of common carbapenem and CR genes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210686PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681944PMC
March 2020
5 Reads

Comparative Epidemiology and Resistance Trends of in Urinary Tract Infections of Inpatients and Outpatients: A 10-Year Retrospective Study.

Antibiotics (Basel) 2019 Jul 11;8(3). Epub 2019 Jul 11.

Department of Public Health, Faculty of Medicine, University of Szeged, 6720 Szeged, Dóm tér 10., Hungary.

Compared with infections caused by other bacterial pathogens, urinary tract infections (UTIs) caused by are often more severe and associated with a higher rate of recurrence, sequelae, and pyelonephritis. The aim of this retrospective study was to assess and compare the prevalence of UTIs caused by different species of the tribe (namely , and species) and the antibiotic resistance levels isolated from inpatients and outpatients in a primary- and tertiary-care teaching hospital in the Southern Great Plain of Hungary, during a 10-year study period. To evaluate the resistance trends of isolated strains, amoxicillin/clavulanic acid, ceftriaxone, meropenem, ertapenem, gentamicin, ciprofloxacin, and fosfomycin were chosen as indicator antibiotics, based on local antibiotic utilization data. Read More

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https://www.mdpi.com/2079-6382/8/3/91
Publisher Site
http://dx.doi.org/10.3390/antibiotics8030091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783862PMC
July 2019
4 Reads

Beta-Lactam/Beta-Lactamase Inhibitor Therapy for Potential AmpC-Producing Organisms: A Systematic Review and Meta-Analysis.

Open Forum Infect Dis 2019 Jul;6(7)

Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Canada.

The optimal treatment for potential AmpC-producing Enterobacteriaceae, including Serratia, Providencia, Citrobacter, Enterobacter, and Morganella species, remains unknown. An updated systematic review and meta-analysis of studies comparing beta-lactam/beta-lactamase inhibitors with carbapenems in the treatment of bloodstream infections with these pathogens found no significant difference in 30-day mortality (OR, 1.13; 95% CI, 0. Read More

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http://dx.doi.org/10.1093/ofid/ofz248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656656PMC
July 2019
4 Reads

Genome-based insights into the resistomes and mobilomes of two Providencia rettgeri strains isolated from wound infections in Madagascar.

J Glob Antimicrob Resist 2020 Mar 17;20:178-182. Epub 2019 Jul 17.

Institut Pasteur de Madagascar, Antananarivo, Madagascar.

Objectives: A molecular analysis was performed of two Providencia rettgeri (P. rettgeri) strains (Pr 297 and Pr 269) collected in 2007 and 2009 from wound swabs of patients admitted to the intensive care units at Joseph Ravoangy Andrianavalona hospital and the Military Hospital in Antananarivo, Madagascar.

Methods: The two P. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.07.013DOI Listing
March 2020
2 Reads

Bacterial profile and antimicrobial susceptibility patterns in chronic suppurative otitis media at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

BMC Res Notes 2019 Jul 15;12(1):414. Epub 2019 Jul 15.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box: 196, Gondar, Ethiopia.

Objectives: This study aims to determine bacterial profile and antimicrobial susceptibility patterns of chronic suppurative otitis media in the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

Result: Sixty-two ear swabs were collected and 74 bacterial isolates were identified, of which 48 (77.4%) sample with mono-microbial growth, 11 (17. Read More

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http://dx.doi.org/10.1186/s13104-019-4452-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631645PMC
July 2019
2 Reads

Earliest identification of New Delhi metallo-β-lactamase 1 (NDM-1) in Acinetobacter pittii in Brazil.

Rev Soc Bras Med Trop 2019 Jun 27;52:e20180348. Epub 2019 Jun 27.

Departamento de Medicina, Escola de Medicina, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brasil.

We report the occurrence in Brazil of the bla NDM-1 gene in Acinetobacter pittii, prior to the previously described first reports regarding the species Providencia rettgeri and Enterobacter hormaechei. Clinical isolates were investigated by polymerase chain reaction followed by bidirectional sequencing, and species was confirmed by 16S rDNA sequencing and matrix-assisted laser desorption-ionization time-of-flight spectrometry. A. Read More

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http://dx.doi.org/10.1590/0037-8682-0348-2018DOI Listing
June 2019
1 Read

Epidemiology and Pathogenesis of Infections.

Am J Trop Med Hyg 2019 08;101(2):290-293

Centre for Infectious Disease Research in Asia and Africa, Nagasaki University Institute of Tropical Medicine, Nagasaki, Japan.

is a member of the family Enterobacteriaceae that has been commonly implicated as a causative agent of diarrheal infection in humans and animals. Recent outbreaks of in both developing and developed countries have raised public health concerns. Several studies have suggested that can cause diarrhea by invading the intestinal mucosa, although its pathogenicity has not been well established. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685554PMC
August 2019
4 Reads

Transcriptomic response of rainbow trout (Oncorhynchus mykiss) skeletal muscle to Flavobacterium psychrophilum.

Comp Biochem Physiol Part D Genomics Proteomics 2019 09 29;31:100596. Epub 2019 May 29.

Universidad Andrés Bello, Facultad de Ciencias de la Vida, Laboratorio de Biotecnología Molecular, Santiago, Chile; Interdisciplinary Center for Aquaculture Research (INCAR), Concepción, Chile; Universidad Andrés Bello, Centro de Investigación Marina Quintay (CIMARQ), Quintay, Chile. Electronic address:

Flavobacterium psychrophilum is the etiologic agent of rainbow trout fry syndrome (RTFS). This pathogen infects a wide variety of salmonid species during freshwater stages, causing significant losses in the aquaculture industry. Rainbow trout (Oncorhynchus mykiss) infected with F. Read More

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http://dx.doi.org/10.1016/j.cbd.2019.100596DOI Listing
September 2019
5 Reads

Evaluation of cultivable aerobic bacterial flora from Russell's viper (Daboia russelii) oral cavity.

Microb Pathog 2019 Sep 1;134:103573. Epub 2019 Jun 1.

Department of Zoology, Utkal University, Bhubaneswar, 751004, Odisha, India. Electronic address:

Snake mouths contain a wide range of bacteria. Identifying these bacteria in snakes is very important to obtain an understanding of the etiological agents of secondary infections that may result from accidents during handling and/or snake bites. The present study aims to determine the pattern of oral bacterial flora of nine healthy Russell's vipers (Daboia russelii), and their susceptibility to common antibiotics. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.103573DOI Listing
September 2019
19 Reads
2.000 Impact Factor

Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus.

Front Microbiol 2019 3;10:873. Epub 2019 May 3.

Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile.

The human respiratory syncytial virus (hRSV) is the main etiologic agent of severe lower respiratory tract infections that affect young children throughout the world, associated with significant morbidity and mortality, becoming a serious public health problem globally. Up to date, no licensed vaccines are available to prevent severe hRSV-induced disease, and the generation of safe-effective vaccines has been a challenging task, requiring constant biomedical research aimed to overcome this ailment. Among the difficulties presented by the study of this pathogen, it arises the fact that there is no single animal model that resembles all aspects of the human pathology, which is due to the specificity that this pathogen has for the human host. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510261PMC
May 2019
5 Reads

Draft Genome Sequence of Providencia rettgeri APW139_S1, an NDM-18-Producing Clinical Strain Originating from Hospital Effluent in South Africa.

Microbiol Resour Announc 2019 May 23;8(21). Epub 2019 May 23.

Discipline of Microbiology, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Durban, South Africa

is an opportunistic pathogen implicated in various clinical infections. Here, we report the genome sequence of a strain isolated from hospital effluent in South Africa, which harbors the New Delhi metallo-β-lactamase (NDM) variant 18 gene (). The 4,835,047-bp genome encodes a resistome and virulome that are of cardinal importance to infections. Read More

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http://dx.doi.org/10.1128/MRA.00259-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533383PMC
May 2019
6 Reads

Cellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization.

Mol Immunol 2019 07 9;111:198-204. Epub 2019 May 9.

Sección de Biotecnología, Instituto de Salud Pública de Chile, Santiago, Chile; Facultad de Medicina y Ciencia, Universidad San Sebastián. Providencia, Santiago, Chile. Electronic address:

Group B Streptococcus (GBS) represents one of the most common causes of bacterial infection in neonates; it is also associated with premature childbirth and stillbirth. A vaccine against GBS is needed, but no approved vaccines are yet available. The Surface Immunogenic Protein (SIP) of GBS is conserved in all serotypes and had been reported to be a good vaccine prototype in a mouse model of GBS infection. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.04.025DOI Listing
July 2019
13 Reads

Dissemination of NDM-1 carbapenemase-producer Providencia stuartii strains in Romanian hospitals: a multicentre study.

J Hosp Infect 2019 Oct 27;103(2):165-169. Epub 2019 Apr 27.

Tîrgu-Mures County Emergency Clinical Hospital, Romania; University of Medicine, Pharmacy, Science and Technology of Tîrgu-Mureş, Romania.

Several Romanian hospitals have noted increasing isolation of Providencia stuartii strains in recent years, with an alarming rate of carbapenem resistance. In order to provide molecular epidemiological data regarding their dissemination, 77 P. stuartii strains collected from five hospitals located in different regions of Romania were analysed. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.04.015DOI Listing
October 2019
6 Reads

Oxidative stress and antioxidant responses in Nile tilapia Oreochromis niloticus experimentally infected by Providencia rettgeri.

Microb Pathog 2019 Jun 9;131:164-169. Epub 2019 Apr 9.

Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Bacterial diseases are one of the major problems in freshwater fish culture and have been linked to significant losses and high mortality rate. In this study, Nile tilapia Oreochromis niloticus was infected by Providencia rettgeri to evaluate the oxidative stress and antioxidant responses in the fish tissues. Juvenile Nile tilapia was divided into two groups, as follow: control (uninfected) and experimentally infected with 100 μL of P. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.007DOI Listing
June 2019
10 Reads

Bacterial Infections Associated with Viperidae Snakebites in Children: A 14-Year Experience at the Hospital Nacional de Niños de Costa Rica.

Am J Trop Med Hyg 2019 05;100(5):1227-1229

Center for Infectious Disease Modeling and Analysis (CIDMA), Yale University, New Haven, Connecticut.

Secondary bacterial infections following Viperidae snakebite envenomation in children are common. Among 75 patients admitted because of snakebites at the only pediatric hospital in Costa Rica, 16 (21.3%) had a culture-confirmed secondary bacterial infection. Read More

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http://dx.doi.org/10.4269/ajtmh.18-1015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493952PMC
May 2019
11 Reads

A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis.

BMC Res Notes 2019 Mar 4;12(1):119. Epub 2019 Mar 4.

Roche-Peru, Av Dionisio Derteano #144, San Isidro, Lima 27, Peru.

Objective: This exploratory study assessed the safety of the combination of sulfamethoxazole, trimethoprim and guaifenesin (STG) in adult and pediatric patients with acute bronchitis according to local labelling in Peru.

Results: We enrolled 51 pediatric and 52 adult participants diagnosed with acute bronchitis and indication of STG. The mean ages were 7. Read More

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http://dx.doi.org/10.1186/s13104-019-4150-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399863PMC
March 2019
5 Reads

Diversity of carbapenemases in clinical isolates: The emergence of bla in Bangladesh.

J Infect Chemother 2019 Jun 26;25(6):444-451. Epub 2019 Feb 26.

Department of Microbiology, University of Dhaka, Dhaka, 1000, Bangladesh. Electronic address:

Global emergence and dissemination of carbapenemases are clinically threatening, notably in countries with endemic bla. To analyze the extent of carbapenemases in Bangladesh, 71 isolates were collected from 7 different clinical sources: wound swab (n = 38), pus (n = 13), urine (n = 9), blood (n = 4), tracheal aspirate (n = 3), pleural fluid (n = 1) and vaginal swab (n = 3) from Dhaka Medical College Hospital, Bangladesh. Among the isolates, 25 were resistant to at least one of the three carbapenems (imipenem, meropenem and doripenem), including 15 being resistant to all. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.010DOI Listing
June 2019
3 Reads
1.384 Impact Factor

d-Serine Degradation by Proteus mirabilis Contributes to Fitness during Single-Species and Polymicrobial Catheter-Associated Urinary Tract Infection.

mSphere 2019 02 27;4(1). Epub 2019 Feb 27.

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA

is a common cause of catheter-associated urinary tract infection (CAUTI) and secondary bacteremia, which are frequently polymicrobial. We previously utilized transposon insertion-site sequencing (Tn-Seq) to identify novel fitness factors for colonization of the catheterized urinary tract during single-species and polymicrobial infection, revealing numerous metabolic pathways that may contribute to fitness regardless of the presence of other cocolonizing organisms. One such "core" fitness factor was d-serine utilization. Read More

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http://dx.doi.org/10.1128/mSphere.00020-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393727PMC
February 2019
34 Reads

Development of a multiplex PCR targeting eae, stx and cdt genes in genus Escherichia and detection of a novel cdtB gene in Providencia rustigianii.

Pathog Dis 2018 12 1;76(9). Epub 2018 Dec 1.

Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58, Rinkuourai-kita, Izumisano, Osaka 598-8531, Japan.

This study was aimed to develop a multiplex PCR (m-PCR) for the detection of Escherichia coli attaching and effacing (eae), Shiga toxin (stx) and cytolethal distending toxin (cdt) genes encoding important virulence factors of diarrheagenic E. coli such as EPEC, STEC, and Escherichia albertii. For this purpose, the m-PCR was designed to detect eae, all the subtypes of stx (stx1, stx2a-g except stx2f) and cdt (I-V) genes. Read More

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http://dx.doi.org/10.1093/femspd/ftz002DOI Listing
December 2018
9 Reads

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.

J Antimicrob Chemother 2019 04;74(4):944-952

Institute of Medical Microbiology, University of Zürich, Gloriastrasse 30, Zürich, Switzerland.

Objectives: Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects. Apramycin, an aminoglycoside antibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in carbapenemase-producing clinical isolates. This study evaluates the in vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii, and provides a rationale for its superior antibacterial activity in the presence of aminoglycoside resistance determinants. Read More

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https://academic.oup.com/jac/advance-article/doi/10.1093/jac
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http://dx.doi.org/10.1093/jac/dky546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419615PMC
April 2019
46 Reads

Myiasis-induced sepsis: a rare case report of Wohlfahrtiimonas chitiniclastica and Ignatzschineria indica bacteremia in the continental United States.

Medicine (Baltimore) 2018 Dec;97(52):e13627

Trauma and Acute Care Surgery, Indiana University Health Methodist Hospital, Indianapolis, Indiana.

Rationale: The presentation of sepsis and bacteremia in cutaneous and cavitary myiasis is uncommon. We present a patient, residing in a temperate region of the United States, with myiasis and sepsis from the emerging human pathogens Wohlfahrtiimonas chitiniclastica and Ignatzschineria indica.

Patient Concerns: A 37-year-old male patient with an 8-month history of chronic lymphedema and ulcers of the lower left extremity presented with myiasis of the left foot and leg. Read More

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http://dx.doi.org/10.1097/MD.0000000000013627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314694PMC
December 2018
11 Reads

Influence of various uropathogens on crystallization of urine mineral components caused by Proteus mirabilis.

Res Microbiol 2019 Mar 4;170(2):80-85. Epub 2018 Dec 4.

Department of Biology of Bacteria, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. Electronic address:

Infectious urolithiasis is a consequence of long-standing urinary tract infections with urease-positive bacteria, especially Proteus spp. However, because of the often mixed nature of urinary tract infections, in the case of urinary stones formation, several species of bacteria may be involved in the process. The purpose of the study was to determine the impact of the bacterial species: Escherichia coli, Klebsiella pneumoniae, Providencia stuartii, Pseudomonas aeruginosa and Staphylococcus aureus on the crystallization caused by Proteus mirabilis. Read More

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http://dx.doi.org/10.1016/j.resmic.2018.11.005DOI Listing
March 2019
10 Reads

SuperPolymyxin™ Medium for the Screening of Colistin-Resistant Gram-Negative Bacteria in Stool Samples.

Front Microbiol 2018 21;9:2809. Epub 2018 Nov 21.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Colistin is one of the last resort antimicrobials for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. After the emergence of transferable colistin resistance genes (-1-5), a reliable culture-based screening method to detect colonization with colistin-resistant Gram-negative bacteria (CRGN) is needed. The objective of this study was to test the performance of SuperPolymyxin™ medium to screen for CRGN in stool samples and to compare different methods for the confirmation of colistin resistance (e. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258816PMC
November 2018
10 Reads

Potential uses of an infodemiology approach for health-care services for rheumatology.

Clin Rheumatol 2019 Mar 17;38(3):869-876. Epub 2018 Nov 17.

Unidad de Investigación en Enfermedades Cronico-Degenerativas, Colomos 2292, Providencia, 44620, Guadalajara, Jalisco, Mexico.

Objectives: This is a demand-based infodemiology study using the Google Trends and AdWords tools to illustrate infodemiology's potential use in rheumatology. The study investigates three questions in North American countries: (1) What terms associated with "rheumatology" and "arthritis" do people search for on Google? (2) What is the search volume for disease-modifying antirheumatic drugs (DMARDs)? and (3) What is the search volume for the term "arthritis" compared with for "hepatitis C" and "breast cancer"?

Methods: We conducted independent searches by country and search term for 2015-2017. Seventeen DMARDs were searched for 2015 through May 2018, with the turmeric remedy included for comparison. Read More

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http://link.springer.com/10.1007/s10067-018-4364-z
Publisher Site
http://dx.doi.org/10.1007/s10067-018-4364-zDOI Listing
March 2019
43 Reads