6,706 results match your criteria Proteus Infections


Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection.

PLoS Pathog 2019 Apr 22;15(4):e1007653. Epub 2019 Apr 22.

Department of Microbiology and Immunology; University of Michigan Medical School; Ann Arbor, MI, United States of America.

The Gram-negative bacterium Proteus mirabilis is a common cause of catheter-associated urinary tract infections (CAUTI), which can progress to secondary bacteremia. While numerous studies have investigated experimental infection with P. mirabilis in the urinary tract, little is known about pathogenesis in the bloodstream. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007653DOI Listing

Rapid screening of engineered microbial therapies in a 3D multicellular model.

Proc Natl Acad Sci U S A 2019 Apr 17. Epub 2019 Apr 17.

Department of Biomedical Engineering, Columbia University, New York, NY 10027;

Synthetic biology is transforming therapeutic paradigms by engineering living cells and microbes to intelligently sense and respond to diseases including inflammation, infections, metabolic disorders, and cancer. However, the ability to rapidly engineer new therapies far outpaces the throughput of animal-based testing regimes, creating a major bottleneck for clinical translation. In vitro approaches to address this challenge have been limited in scalability and broad applicability. Read More

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http://dx.doi.org/10.1073/pnas.1820824116DOI Listing
April 2019
1 Read

Uropathogens and their antimicrobial resistance patterns: Relationship with urinary tract infections.

Int J Health Sci (Qassim) 2019 Mar-Apr;13(2):48-55

Department of Pathology and Laboratory Medicine, College of Medicine, Qassim University, Saudi Arabia.

Objectives: This study was performed to determine the prevalence of uropathogens causing urinary tract infections (UTIs) and to determine their pattern of antimicrobial resistance.

Methods: This study was conducted on 273 urine samples collected from outpatient departments (OPDs) of Qassim University affiliated hospitals. Fully automated VITEK 2 compact system was used in the identification and antimicrobial susceptibility testing of causative microorganisms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436442PMC

Plazomicin Is Active Against Metallo-β-Lactamase-Producing Enterobacteriaceae.

Open Forum Infect Dis 2019 Apr 12;6(4):ofz123. Epub 2019 Mar 12.

Department of Clinical Microbiology, Achaogen, Inc., South San Francisco, California.

Plazomicin is an aminoglycoside that was approved in June 2018 by the US Food and Drug Administration for the treatment of complicated urinary tract infections, including pyelonephritis, due to , , , and . Plazomicin was engineered to overcome the most common aminoglycoside resistance mechanism, inactivation by aminoglycoside-modifying enzymes, but is not active against the less common 16S ribosomal RNA methyltransferases (16S-RMTase), which confer target site modification. As an aminoglycoside, plazomicin maintains activity against Enterobacteriaceae that express resistance mechanisms to other antibiotic classes, including metallo-β-lactamases. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz12
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http://dx.doi.org/10.1093/ofid/ofz123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446133PMC
April 2019
2 Reads

An OXA-23-producing clone spreads under the radar in the French community.

Antimicrob Agents Chemother 2019 Apr 8. Epub 2019 Apr 8.

UMR6249 CNRS Chrono-Environnement, Université de Bourgogne Franche-Comté, Besançon, France.

Nineteen isolates producing carbapenemase OXA-23 were recovered over a 2-year period in 19 French hospitalized patients, of whom 12 had community-onset infections. The isolates exhibited a slightly reduced susceptibility to carbapenems. Compared to other 149 , whole genome analysis revealed that all 19 isolates formed a cluster. Read More

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http://dx.doi.org/10.1128/AAC.00191-19DOI Listing
April 2019
1 Read

Obese patients have higher rates of polymicrobial and Gram-negative early periprosthetic joint infections of the hip than non-obese patients.

PLoS One 2019 8;14(4):e0215035. Epub 2019 Apr 8.

Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Obese patients are more likely to develop periprosthetic joint infection (PJI) after primary total joint arthroplasty. This study compared the clinical and microbiological characteristics of non-obese, obese and severely obese patients with early PJI, in order to ultimately optimize antibiotic prophylaxis and other prevention measures for this specific patient category.

Methods: We retrospectively evaluated patients with early PJI of the hip and knee treated with debridement, antibiotics and implant retention (DAIR) between 2006 and 2016 in three Dutch hospitals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215035PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453483PMC
April 2019
3 Reads
3.234 Impact Factor

Innovations in Worksite Diagnosis of Urinary Tract Infections and the Occupational Health Nurse.

Workplace Health Saf 2019 Mar 29:2165079919834310. Epub 2019 Mar 29.

2 GeneCapture, Inc.

Occupational health nurses play a key role in evaluating innovative technologies that can aid in providing safe and rapid care and reduce lost work time. A nurse-led employee health clinic participated in a validation study of a novel pathogen detection technique developed by GeneCapture, Inc. Their proposed portable urinary tract infection (UTI) in vitro diagnostic test was challenged with discarded, deidentified urine samples from patients presenting with typical UTI symptoms collected at two university clinics and two multiphysician practices. Read More

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http://dx.doi.org/10.1177/2165079919834310DOI Listing

The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes.

Malays J Med Sci 2019 Jan 28;26(1):107-114. Epub 2019 Feb 28.

Pathology Department, Hospital Raja Perempuan Zainab 2, 15586 Kota Bharu, Kelantan, Malaysia.

Background: Foot infection is a major complication of diabetes mellitus (DM) and its agents are usually polymicrobial. This study aims to describe the agent and determine the association between polymicrobial infections and the severity of diabetic foot infections (DFI) and their outcomes.

Methods: This retrospective cohort study was conducted during one year and it involved 104 patients. Read More

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http://dx.doi.org/10.21315/mjms2019.26.1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419864PMC
January 2019
1 Read

Evaluation of antibacterial efficacy of sulfur nanoparticles alone and in combination with antibiotics against multidrug-resistant uropathogenic bacteria.

J Environ Sci Health A Tox Hazard Subst Environ Eng 2019 Mar 26:1-10. Epub 2019 Mar 26.

a Nanobiotechnology Lab., Department of Biotechnology , SGB Amravati University , Amravati , India.

Urinary tract infections (UTIs) have been frequently reported from different parts of the world. The current knowledge on distribution of causative agents of urinary infections and antibiotics susceptibility pattern is essentially required. In the present study, total 351 uropathogenic bacteria were isolated; among them most prevalent were Escherichia coli (75%), followed by Pseudomonas aeruginosa (8%), Proteus mirabilis (6%), Klebsiella pneumoniae (4%), Staphylococcus aureus (4%) and Enterococcus faecalis (3%). Read More

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http://dx.doi.org/10.1080/10934529.2018.1558892DOI Listing
March 2019
2 Reads

Characterization of β-lactamase content of ceftazidime-resistant pathogens recovered during the pathogen-directed Phase 3 trial (REPRISE) for ceftazidime-avibactam: Correlation of efficacy against β-lactamase producers.

Antimicrob Agents Chemother 2019 Mar 25. Epub 2019 Mar 25.

JMI Laboratories, North Liberty, IA 52317, USA.

REPRISE was a pathogen-directed (ceftazidime-resistant) Phase 3 prospective, open-label, randomized, multicenter trial that evaluated the efficacy, safety, and tolerability of ceftazidime-avibactam (CAZ-AVI) and best available therapy (BAT) in the treatment of hospitalized adults with complicated intra-abdominal (cIAI) and complicated urinary tract infections (cUTI). This study characterized the β-lactamase content of ceftazidime-resistant and recovered during the baseline visits of patients enrolled in REPRISE. Ceftazidime had MIC results of >64 μg/mL against baseline and variants were the most common β-lactamase found in (detected in 94. Read More

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http://dx.doi.org/10.1128/AAC.02655-18DOI Listing
March 2019
1 Read
4.476 Impact Factor

Prevalence of Bacterial Urinary Tract Infections and Associated Factors among Patients Attending Hospitals in Bushenyi District, Uganda.

Int J Microbiol 2019 17;2019:4246780. Epub 2019 Feb 17.

Department of Microbiology, Faculty of Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.

Urinary tract infections (UTIs) are one of the major causes of morbidity and comorbidities in patients with underlying conditions, and it accounts for the majority of the reasons for hospital visit globally. Sound knowledge of factors associated with UTI may allow timely intervention that can easily bring the disease under control. This study was designed to determine the prevalence of UTI by isolating and characterizing the different bacterial etiological agents and to evaluate the factors associated with UTI. Read More

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http://dx.doi.org/10.1155/2019/4246780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397969PMC
February 2019
2 Reads

Effect of Crude Bark Extracts Concentrations against Gram-Positive and Gram-Negative Bacterial Pathogens.

J Pharm Bioallied Sci 2019 Jan-Mar;11(1):33-37

Department of Pathology, Sri Lakshmi Narayana Institute of Medical Science Medical College and Hospital, Puducherry, India.

Background: Today's pharmaceutical markets are crowded with antibacterial agents, yet their toxicities and resistance are always contentious. is used in India as an age-old treatment for diverse medical conditions. This study was put forth to analyze the antibacterial action of bark extract on different bacterial pathogens. Read More

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http://dx.doi.org/10.4103/jpbs.JPBS_150_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394162PMC
March 2019
2 Reads

AmpC β-lactamase-producing Enterobacterales: what a clinician should know.

Infection 2019 Mar 6. Epub 2019 Mar 6.

Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy.

Background: Enterobacterales are among the most common causes of bacterial infections in the community and among hospitalized patients, and multidrug-resistant (MDR) strains have emerged as a major threat to human health. Resistance to third-generation cephalosporins is typical of MDRs, being mainly due to the production of extended spectrum β-lactamases or AmpC-type β-lactamases.

Objective: The objective of this paper is to review the epidemiological impact, diagnostic issues and treatment options with AmpC producers. Read More

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http://dx.doi.org/10.1007/s15010-019-01291-9DOI Listing
March 2019
14 Reads

Portable bacteria-capturing chip for direct surface-enhanced Raman scattering identification of urinary tract infection pathogens.

R Soc Open Sci 2018 Sep 5;5(9):180955. Epub 2018 Sep 5.

Chair for Analytical Chemistry, Institute of Hydrochemistry, Technische Universität München, Marchioninistrasse 17, 81377 Munich, Germany.

Acute urinary tract infections (UTIs) are one of the most common nosocomial bacterial infections, which affect almost 50% of the population at least once in their lifetime. UTIs may lead to lethal consequences if they are left undiagnosed and not properly treated. Early, rapid and accurate uropathogens detection methods play a pivotal role in clinical process. Read More

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http://dx.doi.org/10.1098/rsos.180955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170559PMC
September 2018
3 Reads

Incidence, root causes, and outcomes of surgical site infections in a tertiary care hospital in Rwanda: a prospective observational cohort study.

Patient Saf Surg 2019 18;13:10. Epub 2019 Feb 18.

1Infection Control Unit, Kigali University Teaching Hospital, Kigali, Rwanda.

Background: Surgical Site Infections (SSI) are the most reported health acquired infection and common surgical complication in both developed and developing countries. In developing countries such as Rwanda, there is a paucity of published reports on the pattern of SSI, therefore this study aimed at assessing the incidence, risk factors and the antibiotic profile of pathogens responsible of SSI.

Methods: This prospective study included 294 patients admitted between October 10, 2017 and February 12, 2018 to the surgical department of the University Teaching Hospital of Kigali. Read More

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https://pssjournal.biomedcentral.com/articles/10.1186/s13037
Publisher Site
http://dx.doi.org/10.1186/s13037-019-0190-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378727PMC
February 2019
7 Reads

d-Serine Degradation by Proteus mirabilis Contributes to Fitness during Single-Species and Polymicrobial Catheter-Associated Urinary Tract Infection.

mSphere 2019 02 27;4(1). Epub 2019 Feb 27.

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA

is a common cause of catheter-associated urinary tract infection (CAUTI) and secondary bacteremia, which are frequently polymicrobial. We previously utilized transposon insertion-site sequencing (Tn-Seq) to identify novel fitness factors for colonization of the catheterized urinary tract during single-species and polymicrobial infection, revealing numerous metabolic pathways that may contribute to fitness regardless of the presence of other cocolonizing organisms. One such "core" fitness factor was d-serine utilization. Read More

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http://dx.doi.org/10.1128/mSphere.00020-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393727PMC
February 2019
3 Reads

Bacterial biofilm formation on indwelling urethral catheters.

Lett Appl Microbiol 2019 Apr;68(4):277-293

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK.

Urethral catheters are the most commonly deployed medical devices and used to manage a wide range of conditions in both hospital and community care settings. The use of long-term catheterization, where the catheter remains in place for a period >28 days remains common, and the care of these patients is often undermined by the acquisition of infections and formation of biofilms on catheter surfaces. Particular problems arise from colonization with urease-producing species such as Proteus mirabilis, which form unusual crystalline biofilms that encrust catheter surfaces and block urine flow. Read More

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http://dx.doi.org/10.1111/lam.13144DOI Listing

In-vitro antibacterial and anti-encrustation performance of silver-polytetrafluoroethylene nanocomposite coated urinary catheters.

J Hosp Infect 2019 Feb 22. Epub 2019 Feb 22.

School of Science and Engineering, University of Dundee, Dundee, UK. Electronic address:

Background: Catheter-associated urinary tract infections (CAUTIs) are among the most common hospital-acquired infections, leading to increased morbidity and mortality. A major reason for this is that urinary catheters are not yet capable of preventing CAUTIs.

Aim: To develop an anti-infective urinary catheter. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.02.012DOI Listing
February 2019

Molecular drivers of emerging multidrug resistance in Proteus mirabilis clinical isolates from Algeria.

J Glob Antimicrob Resist 2019 Feb 20. Epub 2019 Feb 20.

IRD, APHM, MEPHI, IHU Méditerranée Infection, Aix-Marseille Université, France.

Objective: The goal of this study was to characterize the molecular drivers of multidrug-resistant (MDR) Proteus mirabilis strains, isolated from Algerian community and hospital patients.

Methods: A total of 166 Proteus mirabilis strains were collected from two Hospitals and eight private laboratories from four cities (Khemis Melaina, Ain Defla, Oran and, Chlef) located in northwestern Algeria. All strains were identified by matrix-laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/MS). Read More

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http://dx.doi.org/10.1016/j.jgar.2019.01.030DOI Listing
February 2019
2 Reads

Are Sonication Cultures of Antibiotic Cement Spacers Useful During Second-stage Reimplantation Surgery for Prosthetic Joint Infection?

Clin Orthop Relat Res 2018 Oct;476(10):1986-1992

University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Background: Organisms may persist on polymethylmethacrylate (PMMA) spacer surfaces, and subclinical infection is postulated to be a source of infection recurrence. Several small patient series have shown a high proportion of positive sonication cultures on PMMA spacers at the second stage of a two-stage revision. However, the association between a positive sonication culture and the risk for recurrence of infection after two-stage exchange is not fully elucidated. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259822PMC
October 2018
2 Reads

Monitoring the antimicrobial susceptibility of Gram-negative organisms involved in intraabdominal and urinary tract infections recovered during the SMART study (Spain, 2016 and 2017).

Rev Esp Quimioter 2019 Apr 13;32(2):145-155. Epub 2019 Feb 13.

Rafael Cantón. Servicio de Microbiología. Hospital Universitario Ramón y Cajal. Carretera de Colmenar Km 9,1. 28034 Madrid. Spain.

Objective: Continuous antimicrobial resistance surveillance is recommended by Public Health authorities. We up-dated data from the SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study in Spain.

Methods: The antimicrobial susceptibility data and extended-spectrum beta-lactamase (ESBL) production in isolates recovered from intra-abdominal (IAI) (n=1,429) and urinary tract (UTI) (n=937) infections during the 2016- 2017 SMART study in 10 Spanish hospitals were analysed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441989PMC
April 2019
3 Reads

Orthopedic Implant-Associated Infection by Multidrug Resistant .

J Clin Med 2019 Feb 8;8(2). Epub 2019 Feb 8.

Department of Clinical Microbiology, Hospital Universitario Fundación Jiménez Díaz. IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain.

Introduction: Orthopedic implant-associated infections caused by multidrug-resistant are a growing challenge for healthcare providers due to their increasing incidence and the difficulties of medical and surgical treatment.

Material And Methods: A retrospective observational study of all cases of multidrug resistant orthopedic implant-associated infection diagnosed in a tertiary European hospital from December 2011 to November 2017 was carried out. Clinical records were reviewed using a previously designed protocol. Read More

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http://dx.doi.org/10.3390/jcm8020220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406851PMC
February 2019
1 Read

Quercetin inhibits swarming motility and activates biofilm production of Proteus mirabilis possibly by interacting with central regulators, metabolic status or active pump proteins.

Phytomedicine 2019 Apr 11;57:65-71. Epub 2018 Dec 11.

Ege University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, İzmir 35040, Turkey.

Background: Via its virulence factors such as swarm differentiation, biofilm and hemolysin production, urease enzyme, Proteus mirabilis causes urinary tract infections (UTIs), especially in complicated cases. Anti-pathogenic compounds attenuate the virulence of bacteria without showing 'cidal' activity and carry the potential to be used in the prevention and treatment of infectious diseases.

Purpose: Search for anti-pathogenic effects of quercetin, which is a widely known and biologically active phytochemical, on Proteus mirabilis was the purpose of this study. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.014DOI Listing
April 2019
1 Read

In vitro activity of Plazomicin against Enterobacteriaceae isolates carrying genes encoding aminoglycoside-modifying enzymes most common in US Census divisions.

Diagn Microbiol Infect Dis 2019 May 5;94(1):73-77. Epub 2018 Dec 5.

JMI Laboratories, North Liberty, IA 52317.

Aminoglycoside-nonsusceptible isolates of Escherichia coli, Klebsiella, Proteus, and Enterobacter species (480/3675) from US hospitals collected during 2014-2015 were screened for 16S rRNA methyltransferase and aminoglycoside-modifying enzyme (AME) genes. Only 5 isolates had high aminoglycoside MICs and carried 16S rRNA methyltransferases. AME genes were observed among 89. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.023DOI Listing
May 2019
4 Reads

Using the wax moth larva infection model to detect emerging bacterial pathogens.

PeerJ 2019 4;6:e6150. Epub 2019 Jan 4.

European Centre for Environment and Human Health, University of Exeter, Penryn, UK.

Climate change, changing farming practices, social and demographic changes and rising levels of antibiotic resistance are likely to lead to future increases in opportunistic bacterial infections that are more difficult to treat. Uncovering the prevalence and identity of pathogenic bacteria in the environment is key to assessing transmission risks. We describe the first use of the Wax moth larva , a well-established model for the mammalian innate immune system, to selectively enrich and characterize pathogens from coastal environments in the South West of the UK. Read More

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https://peerj.com/articles/6150
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http://dx.doi.org/10.7717/peerj.6150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322482PMC
January 2019
13 Reads

Biosurfactants and their role in the inhibition of the biofilmforming pathogens.

Ceska Slov Farm Winter 2018;67(3):107-112

Resistance of pathogenic bacteria is currently one of the major medical problems. Most microbial infections are based on the formation of biofilms, which are a significant reservoir of pathogens. The aim of this study is to determine the antibiofilm and antimicrobial activity of biosurfactants isolated from intestinal lactobacilli and marine bacteria. Read More

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April 2019
1 Read

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.

J Antimicrob Chemother 2019 Apr;74(4):944-952

Institute of Medical Microbiology, University of Zürich, Gloriastrasse 30, Zürich, Switzerland.

Objectives: Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects. Apramycin, an aminoglycoside antibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in carbapenemase-producing clinical isolates. This study evaluates the in vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii, and provides a rationale for its superior antibacterial activity in the presence of aminoglycoside resistance determinants. Read More

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https://academic.oup.com/jac/advance-article/doi/10.1093/jac
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http://dx.doi.org/10.1093/jac/dky546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419615PMC
April 2019
15 Reads

Induction of Different Apoptosis Pathways by Two Clinical Isolates Strains in Prostatic Epithelial Cells.

Front Physiol 2018 20;9:1855. Epub 2018 Dec 20.

Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania Luigi Vanvitelli, Naples, Italy.

Bacterial prostatitis is believed to be the leading cause of recurrent urinary tract infections (UTIs) in men under 50 years of age and occurs both as an acute febrile disease responsive to antibiotics and as a chronic infection that is often unresponsive to antibiotic treatment. is more commonly associated with UTIs in these abnormalities, especially in patients undergoing catheterisation. This pathogen is able to colonise the host's tissues and to cause disease thanks to the production of many virulence factors such as fimbriae, flagella, immune avoidance, host-damaging factors, and the ability to form crystalline biofilms. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01855
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http://dx.doi.org/10.3389/fphys.2018.01855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306403PMC
December 2018
6 Reads

Susceptibility patterns of uropathogens identified in hospitalized children.

Pediatr Int 2019 Mar 21;61(3):246-251. Epub 2019 Feb 21.

Department of Pediatrics, Venizeleion General Hospital, Heraklion, Crete, Greece.

Background: Urinary tract infection (UTI) is the most common serious bacterial infection in childhood. The aim of the present study was therefore to identify the organisms responsible for community-acquired febrile UTI in children, to investigate their susceptibility to commonly used antibiotics, and to identify possible risk factors for antibiotic resistance.

Methods: A total of 284 children (male, 38%; female, 62%), who were hospitalized due to a community-acquired UTI over a 5 year period in a general district hospital of southern Greece, were enrolled in the study. Read More

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http://doi.wiley.com/10.1111/ped.13772
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http://dx.doi.org/10.1111/ped.13772DOI Listing
March 2019
16 Reads
0.731 Impact Factor

Clonal relatedness of Proteus mirabilis strains causing urinary tract infections in companion animals and humans.

Vet Microbiol 2019 Jan 22;228:77-82. Epub 2018 Oct 22.

Interdisciplinary Centre of Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477, Lisboa, Portugal. Electronic address:

Proteus mirabilis is a major cause of urinary tract infection (UTI) in humans and companion animals. This study aimed to evaluate the antimicrobial resistance, virulence and clonal relatedness of P. mirabilis isolated from dogs, cats and humans with UTI. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.10.015DOI Listing
January 2019
3 Reads

Unexpected source of bacteraemia.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of General Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Mycotic (infected) aneurysm involving the thoracic aorta is an exceedingly rare and life-threatening condition that is associated with high morbidity and mortality. We report an unusual source of bacteraemia thought to be due to an infected aneurysm in the thoracic aortic arch in an elderly woman. Source of gram-negative bacteraemia is usually isolated to an intra-abdominal or a pelvic source. Read More

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http://dx.doi.org/10.1136/bcr-2018-226744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301452PMC
December 2018
7 Reads

Asymptomatic Bacteriuria and Anti-Microbial Susceptibility Patterns among Women of Reproductive Age. A Cross-Sectional Study in Primary Care, Ghana.

Med Sci (Basel) 2018 Dec 17;6(4). Epub 2018 Dec 17.

Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi, Ghana.

Asymptomatic bacteriuria (ASB) poses serious future clinical repercussions for reproductive women. The study determined the prevalence of asymptomatic bacteriuria along with anti-microbial susceptibility patterns among women of reproductive age in a primary care facility. The study recruited a total of 300 women of reproductive age attending the Tetteh Quarshie Memorial Hospital at Akuapem-Mampong, Ghana, between January and March 2018. Read More

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http://dx.doi.org/10.3390/medsci6040118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313490PMC
December 2018

Prevalence of metallo-β-lactamase acquired genes among carbapenems susceptible and resistant Gram-negative clinical isolates using multiplex PCR, Khartoum hospitals, Khartoum Sudan.

BMC Infect Dis 2018 Dec 17;18(1):668. Epub 2018 Dec 17.

Medical Microbiology Department, Faculty of Medical Laboratory Science, Al Neelain University, Khartoum, Sudan.

Background: The increased prevalence of carbapenem-resistant Gram-negative isolates caused by Metallo-β-lactamase (MBL) is worrisome in clinical settings worldwide. The mortality rate associated with infections caused by MBLs producing organisms ranging from 18 to 67%. This study aimed to determine the prevalence of Metallo-β-lactamase genes among some Gram-negative clinical isolates (Carbapenems susceptible and resistant). Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-018-3581-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296134PMC
December 2018
7 Reads

First prevalence of metallo beta-lactamases producing Enterobacteriacea in Iranian cancer patients.

Authors:
D Zare H Fazeli

Ann Ig 2019 Jan-Feb;31(1):62-68

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Hospital-associated infections, recently renamed Healthcare-associated infections, are among the most common life-threatening complications of hospitalized patients, especially the immunocompromised patients. Regarding the significant role of Enterobacteriaceae in nosocomial infections and also the increasing trends of carbapenem-resistant strains, the present study aimed to evaluate the antibiotic resistance pattern and the occurrence of metallo-beta-lactamases (MBLs) in Enterobacteriaceae strains from Iranian cancer patients.

Methods: This hospital-based cross-sectional study was conducted in teaching hospitals of two cities in the central parts of Iran during the 6 months period from December 2015 to May 2016. Read More

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http://dx.doi.org/10.7416/ai.2019.2259DOI Listing
December 2018
12 Reads

Primary and Secondary Bacteremia Caused by spp.: Epidemiology, Strains Susceptibility and Biofilm Formation.

Pol J Microbiol 2018 ;67(4):471-478

Department of Microbiology, Nicolaus Copernicus University in Toruń, L. Rydygier Collegium Medicum in Bydgoszcz , Poland.

Proteus spp. is an etiological factor of urinary tract and bloodstream infections. The aim of this study was the retrospective analysis of susceptibility of Proteus spp. Read More

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http://dx.doi.org/10.21307/pjm-2018-055DOI Listing
January 2018

In vitro antimicrobial activity of seven adjuvants against common pathogens associated with canine otitis externa.

Vet Dermatol 2019 Apr 13;30(2):133-e38. Epub 2018 Dec 13.

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, 5371, Australia.

Background: An antibiotic adjuvant is a chemical substance used to modify or augment the effectiveness of primary antimicrobial agents against drug-resistant micro-organisms. Its use provides an alternative approach to address the global issue of antimicrobial resistance and enhance antimicrobial stewardship.

Hypothesis/objectives: To determine the antimicrobial activity of a panel of potential antimicrobial adjuvants against common pathogens associated with canine otitis externa (OE). Read More

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http://dx.doi.org/10.1111/vde.12712DOI Listing
April 2019
8 Reads
1.732 Impact Factor

[Surveillance of resistance in the intensive care units using a cumulative antibiogram].

Mikrobiyol Bul 2018 Oct;52(4):329-339

Haydarpaşa Numune Training and Research Hospital, Department of Medical Microbiology, Istanbul, Turkey.

Empiric treatment with broad-spectrum antibiotics exerts condensed pressure in intensive care units (ICUs) for the selection of multidrug-resistant bacteria. Multidrug-resistant gram-negative bacteria became the focus of interest owing to limited treatment options and negative effects on patient survival. Cumulative antibiograms can guide selection of correct empiric treatment, de-escalation treatment according to antibiogram results and development of policies in fight against antibiotic resistance. Read More

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http://dx.doi.org/10.5578/mb.67408DOI Listing
October 2018
6 Reads

Epidemiology of Early-onset Bacterial Neonatal Infections in Madagascar.

Pediatr Infect Dis J 2019 Jan;38(1):76-81

Association Jeremi Rhône-Alpes, Lyon, France.

Background: Little is known about early-onset neonatal bacterial infections (EONBI) in Madagascar. Our aim was to determine their epidemiology to improve their management.

Methods: Inborn neonates at risk for EONBI and admitted in the neonatal unit of 2 tertiary hospitals in Antananarivo, Madagascar, were included in a prospective study from April 2012 to March 2013. Read More

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http://dx.doi.org/10.1097/INF.0000000000001993DOI Listing
January 2019
6 Reads

Influence of various uropathogens on crystallization of urine mineral components caused by Proteus mirabilis.

Res Microbiol 2019 Mar 4;170(2):80-85. Epub 2018 Dec 4.

Department of Biology of Bacteria, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. Electronic address:

Infectious urolithiasis is a consequence of long-standing urinary tract infections with urease-positive bacteria, especially Proteus spp. However, because of the often mixed nature of urinary tract infections, in the case of urinary stones formation, several species of bacteria may be involved in the process. The purpose of the study was to determine the impact of the bacterial species: Escherichia coli, Klebsiella pneumoniae, Providencia stuartii, Pseudomonas aeruginosa and Staphylococcus aureus on the crystallization caused by Proteus mirabilis. Read More

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http://dx.doi.org/10.1016/j.resmic.2018.11.005DOI Listing
March 2019
4 Reads

SuperPolymyxin™ Medium for the Screening of Colistin-Resistant Gram-Negative Bacteria in Stool Samples.

Front Microbiol 2018 21;9:2809. Epub 2018 Nov 21.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Colistin is one of the last resort antimicrobials for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. After the emergence of transferable colistin resistance genes (-1-5), a reliable culture-based screening method to detect colonization with colistin-resistant Gram-negative bacteria (CRGN) is needed. The objective of this study was to test the performance of SuperPolymyxin™ medium to screen for CRGN in stool samples and to compare different methods for the confirmation of colistin resistance (e. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258816PMC
November 2018
2 Reads

Antibiotic resistance of Enterobacteriaceae causing urinary tract infections in elderly patients living in the community and in the nursing home: a retrospective observational study.

J Antimicrob Chemother 2019 Mar;74(3):775-781

Université de Lorraine, APEMAC, Nancy, France.

Objectives: Although nursing homes are thought to be significant reservoirs of antibiotic-resistant bacteria, very few large population-based studies comparing antibiotic resistance prevalence in nursing homes and in the community have adjusted for patient characteristics. Our objective was to compare the prevalence of antibiotic resistance of Enterobacteriaceae cultured from urine samples of nursing home residents with that of community-dwelling adults, all aged 65 years or older.

Methods: This study analysed around 20 000 positive urine samples sent to a large laboratory in north-eastern France from 2014 to 2017, collected from individuals aged 65 years or older. Read More

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http://dx.doi.org/10.1093/jac/dky488DOI Listing
March 2019
2 Reads

Emerging antimicrobial resistance among strains in bloodstream infections in Toronto, 2006-2016: a retrospective cohort study.

CMAJ Open 2018 Oct-Dec;6(4):E580-E586. Epub 2018 Dec 3.

Department of Microbiology (Mineau, Kozak, Kissoon, Paterson, Oppedisano, Douri, Gogan, Willey, McGeer, Poutanen), University Health Network/Sinai Health System, Toronto, Ont.; Centre intégré de santé et de services sociaux de Chaudière-Appalaches (Mineau), Sainte-Marie, Que.; Lawrence Park Collegiate Institute (Gogan); Departments of Laboratory Medicine and Pathobiology and of Medicine (McGeer, Poutanen), University of Toronto, Toronto, Ont.

Background: Enterobacteriaceae that produce extended-spectrum β-lactamase (ESBL) have emerged as a serious threat, with variable rates depending on geographic region. We determined the prevalence of ESBL-producing , , and in bloodstream infections in Toronto from 2006 through 2016.

Methods: All patients with , , and isolated from blood in a tertiary care microbiology laboratory in Toronto between 2006 and 2016 (1 isolate per species per patient per year) were included in this retrospective cohort study. Read More

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http://cmajopen.ca/lookup/doi/10.9778/cmajo.20180039
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http://dx.doi.org/10.9778/cmajo.20180039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277254PMC
December 2018
7 Reads

Laboratory Diagnosis of Bacterial Vaginosis and Potential Pathogens Other Than Group B Streptococcus in Vaginal Swab of Pregnant Women in Dhaka Medical College Hospital.

Mymensingh Med J 2018 Oct;27(4):834-842

Dr Mst Naznin Tarana, Research Student, Department of Microbiology, Dhaka Medical College, Dhaka, Bangladesh; E-mail:

Pathogenic microorganisms are important cause of maternal and neonatal infections which are transmitted from colonized vagina of mother. The purpose of the present study was to detect the potential pathogens other than Group B Streptococcus in vaginal swab of pregnant women. This prospective cross sectional study was conducted from July 2013 to June 2014 at Dhaka Medical College Hospital, Dhaka, Bangladesh. Read More

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October 2018
4 Reads

The correlation of crystalline and elemental composition of urinary stones with a history of bacterial infections: TXRF, XRPD and PCR-DGGE studies.

Eur Biophys J 2019 Jan 27;48(1):111-118. Epub 2018 Nov 27.

2nd Department of Urology, Medical University of Lodz, Pabianicka St. 62, 93-513, Łódź, Poland.

The aim of this study was to analyze the correlation between past bacterial infections and the type and chemical composition of urinary stones experienced by human patients. Bacteria have been recognized to contribute to urinary stones; however, the role of uropathogens in the development of specific stones has not been extensively investigated. The detection of past bacterial infection (eleven different bacterial species) in urinary stones from 83 patients was made on a DNA level using polymerase chain reaction (PCR) and denaturing gradient gel electrophoresis (DGGE) and correlated with the chemical composition of urinary stones measured using X-ray powder diffraction (XPRD) technique and their elemental composition by total reflection X-ray fluorescence (TXRF). Read More

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http://dx.doi.org/10.1007/s00249-018-1338-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330562PMC
January 2019
19 Reads

Polymerase Chain Reaction Assay Using the Restriction Fragment Length Polymorphism Technique in the Detection of Prosthetic Joint Infections: A Multi-Centered Study.

J Arthroplasty 2019 02 25;34(2):359-364. Epub 2018 Oct 25.

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Behshti University of Medical Sciences, Tehran, Iran; Department of Molecular Biology, Dr. Khosroshahi's Pathobiology Laboratory, Tehran, Iran.

Background: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method.

Methods: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study. Read More

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http://dx.doi.org/10.1016/j.arth.2018.10.017DOI Listing
February 2019
3 Reads

Prevalence and associated factors of urinary tract infections among diabetic patients in Arba Minch Hospital, Arba Minch province, South Ethiopia.

Turk J Urol 2018 Nov 21;45(1):56-62. Epub 2018 Nov 21.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Objective: Urinary tract infection (UTI) is a common and grave health problem in the world. In fact, patients with diabetes mellitus have an immense risk for developing UTI. The development of resistance among uropathogens to antibiotics is a major crisis which limits the use of drug of choice for the treatment of UTI. Read More

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http://dx.doi.org/10.5152/tud.2018.32855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342569PMC
November 2018
2 Reads

The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.

Microb Genom 2018 11 21;4(11). Epub 2018 Nov 21.

1​Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.

Carbapenem resistance is a rapidly growing threat to our ability to treat refractory bacterial infections. To understand how carbapenem resistance is mobilized and spread between pathogens, it is important to study the genetic context of the underlying resistance mechanisms. In this study, the resistomes of six clinical carbapenem-resistant isolates of five different species - Acinetobacter baumannii, Escherichia coli, two Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa - were characterized using whole genome sequencing. Read More

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http://dx.doi.org/10.1099/mgen.0.000233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321870PMC
November 2018
18 Reads

Antimicrobial susceptibilities of specific syndromes created with organ-specific weighted incidence antibiograms (OSWIA) in patients with intra-abdominal infections.

BMC Infect Dis 2018 Nov 19;18(1):584. Epub 2018 Nov 19.

Department of Hospital Infection Control, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Rui-Jin 2nd Road, Shanghai, 200025, China.

Background: The aim was to evaluate the value of organ-specific weighted incidence antibiogram (OSWIA) percentages for bacterial susceptibilities of Gram-negative bacteria (GNB) collected from intra-abdominal infections (IAIs) during SMART 2010-2014.

Methods: We retrospectively calculated the OSWIA percentages that would have been adequately covered by 12 common antimicrobials based on the bacterial compositions found in the appendix, peritoneum, colon, liver, gall bladder and pancreas.

Results: The ESBL positive rates were 65. Read More

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http://dx.doi.org/10.1186/s12879-018-3494-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245934PMC
November 2018
13 Reads