7,345 results match your criteria Proteus Infections

In vitro activity of aztreonam/avibactam against isolates of Enterobacterales collected globally from ATLAS in 2019.

J Glob Antimicrob Resist 2022 Jun 25. Epub 2022 Jun 25.

Pfizer Inc, Kirkland, Canada.

Objectives: Infections caused by drug-resistant Enterobacterales including those producing metallo-β-lactamases (MBLs) are particularly challenging due to limited therapeutic options. The drug combination aztreonam/avibactam (ATM-AVI) is under clinical development for treating serious infections caused by these strains. This study assessed the in vitro activity of ATM-AVI against Enterobacterales isolates collected globally in the ATLAS surveillance programme in 2019. Read More

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Interleukin-6 and C-Reactive Protein: their association with vitamin D in women with recurrent infections of reproductive system.

Egypt J Immunol 2022 Jul;29(3):1-8

Department of Biology, Laboratory of Postgraduates, College of Science, University of Kerbala, Karbala, Iraq.

Aerobic bacteria can colonize the female reproductive system with harmful effects, which may lead to miscarriages, premature deliveries or continue of its growing to cause adverse reproductive systems issues. Increasing in the levels of inflammatory markers may be considered a herald of danger. High vaginal swabs were obtained from 85 women. Read More

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Isolation and Characterization of Lytic Virus 309.

Viruses 2022 Jun 15;14(6). Epub 2022 Jun 15.

Department of Microbiology, Stellenbosch University, Stellenbosch 7600, South Africa.

is frequently associated with complicated urinary tract infections (UTIs) and is the main cause of catheter-associated urinary tract infections (CAUTIs). Treatment of such infections is complicated and challenging due to the biofilm forming abilities of . If neglected or mistreated, infections may lead to life-threating conditions such as cystitis, pyelonephritis, kidney failure, and bacteremia that may progress to urosepsis. Read More

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Enhanced Antibiotic Tolerance of an Multispecies Uropathogen Biofilm Model, Useful for Studies of Catheter-Associated Urinary Tract Infections.

Microorganisms 2022 Jun 13;10(6). Epub 2022 Jun 13.

Section of Microbiology, Department of Biology, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark.

Catheter-associated urinary tract infections (CAUTI) are a common clinical concern as they can lead to severe, persistent infections or bacteremia in long-term catheterized patients. This type of CAUTI is difficult to eradicate, as they are caused by multispecies biofilms that may have reduced susceptibility to antibiotics. Many new strategies to tackle CAUTI have been proposed in the past decade, including antibiotic combination treatments, surface modification and probiotic usage. Read More

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Novel Antimicrobial Strategies to Prevent Biofilm Infections in Catheters after Radical Cystectomy: A Pilot Study.

Life (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Andrological and Urogynecological Clinic, Santa Maria Terni Hospital, University of Perugia, 05100 Terni, Italy.

Catheter-associated infections in bladder cancer patients, following radical cystectomy or ureterocutaneostomy, are very frequent, and the development of antibiotic resistance poses great challenges for treating biofilm-based infections. Here, we characterized bacterial communities from catheters of patients who had undergone radical cystectomy for muscle-invasive bladder cancer. We evaluated the efficacy of conventional antibiotics, alone or combined with the human ApoB-derived antimicrobial peptide r(P)ApoB, to treat ureteral catheter-colonizing bacterial communities on clinically isolated bacteria. Read More

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Bacterial Resistance to Antibiotics and Clonal Spread in COVID-19-Positive Patients on a Tertiary Hospital Intensive Care Unit, Czech Republic.

Antibiotics (Basel) 2022 Jun 8;11(6). Epub 2022 Jun 8.

Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 779 00 Olomouc, Czech Republic.

This observational retrospective study aimed to analyze whether/how the spectrum of bacterial pathogens and their resistance to antibiotics changed during the worst part of the COVID-19 pandemic (1 November 2020 to 30 April 2021) among intensive care patients in University Hospital Olomouc, Czech Republic, as compared with the pre-pandemic period (1 November 2018 to 30 April 2019). A total of 789 clinically important bacterial isolates from 189 patients were cultured during the pre-COVID-19 period. The most frequent etiologic agents causing nosocomial infections were strains of (17%), (11%), (10%), coagulase-negative staphylococci (9%), (8%), (6%), (5%), (5%) and (5%). Read More

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Revisiting the Frequency and Antimicrobial Resistance Patterns of Bacteria Implicated in Community Urinary Tract Infections.

Antibiotics (Basel) 2022 Jun 3;11(6). Epub 2022 Jun 3.

Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

Urinary tract infections (UTIs) are one of the most common infectious diseases at the community level. The continue misuse of antimicrobials is leading to an increase in bacterial resistance, which is a worldwide problem. The objective of this work was to study the incidence and pattern of antimicrobial resistance of the main bacteria responsible for UTI in the community of central and northern Portugal, and establish an appropriate empirical treatment. Read More

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Assessment of Antimicrobial Activity of Ethanolic and Aqueous Extracts of L. (Horse Chestnut) Bark against Bacteria Isolated from Urine of Patients Diagnosed Positive to Urinary Tract Infections.

Front Biosci (Schol Ed) 2022 Apr;14(2):11

Department of Biology and General Genetics, Institute of Medicine, RUDN University, 117198 Moscow, Russia.

The search for new antimicrobials is essential to address the worldwide issue of antibiotic resistance. The present work aimed at assessing the antimicrobial activity of L. (horse chestnut) bark against bacteria involved in urinary tract infections (UTIs). Read More

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activity of mecillinam, temocillin and nitroxoline against MDR Enterobacterales.

JAC Antimicrob Resist 2022 Jun 16;4(3):dlac059. Epub 2022 Jun 16.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Medical faculty and University Hospital of Cologne, Cologne, Germany.

Background: With increasing resistance to common antibiotics the treatment of urinary tract infections has become challenging and alternative therapeutic options are needed. In the present study, we evaluate the activity of three older and less frequently used antibiotics against MDR Enterobacterales.

Methods: Susceptibility of mecillinam, temocillin and nitroxoline was assessed in Enterobacterales isolated from urinary specimens with elevated MICs of third-generation cephalosporins. Read More

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Chemical characterization, antimicrobial, antioxidant, and cytotoxic potentials of Swietenia mahagoni.

AMB Express 2022 Jun 15;12(1):77. Epub 2022 Jun 15.

Department of Microbiology and Immunology, National Research Centre, Dokki, 12622, Cairo, Egypt.

Infectious diseases are the most important cause of death worldwide. Many of these diseases show great resistance to drugs and antibiotics with long-term use. Extracts of some medicinal plants have antimicrobial properties, which can treat and overcome these diseases. Read More

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Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli.

PLoS Pathog 2022 Jun 14;18(6):e1010582. Epub 2022 Jun 14.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.

Extra-intestinal pathogenic Escherichia coli (ExPEC) belong to a critical priority group of antibiotic resistant pathogens. ExPEC establish gut reservoirs that seed infection of the urinary tract and bloodstream, but the mechanisms of gut colonisation remain to be properly understood. Ucl fimbriae are attachment organelles that facilitate ExPEC adherence. Read More

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Enoxacin-based derivatives: antimicrobial and antibiofilm agent: a biology-oriented drug synthesis (BIODS) approach.

Future Med Chem 2022 Jul 13;14(13):947-962. Epub 2022 Jun 13.

H.E.J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan.

To find alternative molecules against ,  and methicillin-resistant , new enoxacin derivatives were synthesized and screened. All derivatives exhibited promising antibacterial activities as compared to standard enoxacin (2 μg/ml) and standard cefixime (82 μg/ml). Compounds , and significantly downregulated the gene expression of biofilm-forming genes. Read More

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One-step coordination of metal-phenolic networks as antibacterial coatings with sustainable and controllable copper release for urinary catheter applications.

RSC Adv 2022 May 25;12(25):15685-15693. Epub 2022 May 25.

Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology, Zhejiang Engineering Research Center for Biomedical Materials, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences Ningbo 315300 China

Catheter-associated urinary tract infections (CAUTIs) draw great concern due to increased demand for urinary catheters in hospitalization. Encrustation caused by urinary pathogens, especially , results in blocking of the catheter lumen and further infections. In this study, a facile and low-cost surface modification strategy of urinary catheters was developed using one-step coordination of tannic acid (TA) and copper ions. Read More

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Microorganism Distributions and Antimicrobial Susceptibility in Community-Onset Bacteremia: A 6-Year Longitudinal Multicenter Cohort in Southern Taiwan.

J Acute Med 2022 Mar;12(1):13-22

National Cheng Kung University Hospital Clinical Medicine Research Center Kaohsiung Taiwan.

Background: Prompt administration of appropriate antimicrobials has been correlated with improved prognoses in patients with bacteremia. Because the Clinical and Laboratory Standards Institute (CLSI) has numerously revised the interpretive criteria of susceptibility to numerous antimicrobials, the updated susceptibility is useful for empirical administration.

Methods: In the multicenter retrospective cohort study consisting of adults with community-onset bacteremia in the emergency department (ED) during the period between January 2010 and December 2015, causative microorganisms were identified by the Vitek 2 system and prospectively collected. Read More

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The effect of fluoroquinolones and antioxidans on biofilm formation by Proteus mirabilis strains.

Ann Clin Microbiol Antimicrob 2022 Jun 2;21(1):22. Epub 2022 Jun 2.

Department of Microbiology, Nicolaus Copernicus University in Toruń, L. Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Background: Fluoroquinolones are a group of antibiotics used in urinary tract infections. Unfortunately, resistance to this group of drugs is currently growing. The combined action of fluoroquinolones and other antibacterial and anti-biofilm substances may extend the use of this therapeutic option by clinicians. Read More

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Augmented Enterocyte Damage During and Coinfection.

Front Cell Infect Microbiol 2022 16;12:866416. Epub 2022 May 16.

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.

The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen adapts to the host environment and additionally interacts with residing bacteria. We investigated fungal-bacterial interactions by coinfecting enterocytes with the yeast and the Gram-negative bacterium resulting in enhanced host cell damage. Read More

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Microbiota of diabetic foot infections in a University Hospital in Bogotá, Colombia.

Foot (Edinb) 2021 Sep 22;52:101867. Epub 2021 Sep 22.

Universidad de la Sabana, Hospital de la Samaritana, Carrera 8 #0-29 Sur, Santa Fé, Bogotá, Cundinamarca, Bogotá, Colombia. Electronic address:

The presence of infection in diabetic foot ulcers (DFU) is one of the main causes of lower limb amputation in the world. The presence of polymicrobial infections is usually the standard for isolation in such lesions, with Gram Positive (GP) germs being the main organisms involved, as is described in the global literature. However, some studies indicate a greater number of isolates with Gram Negative (GN) germs, reported mainly in the literature of Middle Eastern countries and in the tropics. Read More

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September 2021

Synergistic Antibacterial Activity of 1-Methyl Ester-Nigericin and Methyl 5-(Hydroxymethyl) Furan-2-Carboxylate Against spp.

Pak J Biol Sci 2022 Jan;25(4):304-312

<b>Background and Objective:</b> Synergistic combinations of antimicrobial agents with different mechanisms of action are successful approaches for combating bacterial infections. This study aimed to evaluate the synergistic effect of 1-methyl ester-nigericin <b>(1)</b> and methyl 5-(hydroxymethyl) furan-2-carboxylate <b>(2)</b> against <i>Proteus</i> spp., isolates. Read More

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January 2022

Oral Bacteria and Their Antibiotic Susceptibilities in Taiwanese Venomous Snakes.

Microorganisms 2022 Apr 30;10(5). Epub 2022 Apr 30.

Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan.

Wound infections after venomous snakebites are clinically important. Information regarding the nature and antibiotic susceptibilities of snake oral bacterial flora could support empiric antibiotic therapy. Wild venomous snakes were collected from southern Taiwan: a total of 30 each of , , and ; 3 ; and 4 . Read More

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A Method to Determine the Efficacy of a Commercial Phage Preparation against Uropathogens in Urine and Artificial Urine Determined by Isothermal Microcalorimetry.

Microorganisms 2022 Apr 20;10(5). Epub 2022 Apr 20.

Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123 Allschwil, Switzerland.

Background: Urinary tract infections are commonly encountered and often treated with antibiotics. However, the inappropriate use of the latter has led to the appearance of resistant strains. In this context we investigate the use of calorimetry to rapidly determine if a phage cocktail can be used as alternative to antibiotics. Read More

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Urinary Tract Infections in Long-term Care: Evaluation of Uropathogens, Antibiotic Susceptibility, and Empiric Treatment.

Sr Care Pharm 2022 Jun;37(6):232-243

1University of British Columbia, Vancouver, British Columbia, Canada.

To devise a residential empiric treatment algorithm, describe common uropathogens associated with urinary tract infections (UTIs) in residential care, assess all-pathogen and non-ESBL (extended-spectrum beta-lactamase) Escherichia coli antibiotic susceptibilities, and report the percentage of antibiotic use. A retrospective chart review of 198 residents with positive urine cultures from September 2019 to September 2020. Institutional long-term care facility. Read More

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Antimicrobial resistance in urinary pathogens and culture-independent detection of trimethoprim resistance in urine from patients with urinary tract infection.

BMC Microbiol 2022 May 24;22(1):144. Epub 2022 May 24.

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, Northern Ireland.

Background: Although urinary tract infections (UTIs) are extremely common, isolation of causative uropathogens is not always routinely performed, with antibiotics frequently prescribed empirically. This study determined the susceptibility of urinary isolates from two Health and Social Care Trusts (HSCTs) in Northern Ireland to a range of antibiotics commonly used in the treatment of UTIs. Furthermore, we determined if detection of trimethoprim resistance genes (dfrA) could be used as a potential biomarker for rapid detection of phenotypic trimethoprim resistance in urinary pathogens and from urine without culture. Read More

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Antimicrobial Resistance in Bacteria Isolated From Canine Urine Samples Submitted to a Veterinary Diagnostic Laboratory, Illinois, United States.

Front Vet Sci 2022 4;9:867784. Epub 2022 May 4.

Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana Champaign, Urbana, IL, United States.

The emergence of antimicrobial resistance (AMR) in dogs constitutes a threat to animal and human health. There is a lack of studies in Illinois that evaluated the prevalence of AMR among urinary bacterial pathogens. In the study, we included 803 isolates (299 Gram-positive and 504 Gram-negative) that were isolated from 2,583 canine urine samples submitted to the Veterinary Diagnostic Laboratory, the University of Illinois between 2019 and 2020 from dogs suspected of urinary tract infections (UTI). Read More

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Detection of carbapenemases bla-bla-bla-bla and extended-spectrum-β-lactamase bla-bla-bla genes in Gram-negative bacterial isolates from ICU burns patients.

Ann Clin Microbiol Antimicrob 2022 May 19;21(1):18. Epub 2022 May 19.

Institute of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.

Background And Objectives: Burn patients are highly susceptible to invasion by multidrug-resistant Gram-negative bacteria (MDR-GNB) through post-burn damage. The prevalence of MDR-GNB isolated from burns patients has increased dramatically in the last decade, representing a serious risk to patients admitted to burns units worldwide. The challenges of managing infected burns patients are exacerbated in poor resource settings. Read More

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Epidemiologic, microbiologic and imaging characteristics of urinary tract infections in hospitalized children < 2 years of age diagnosed with anatomic abnormalities of the urinary tract.

Pediatr Neonatol 2022 Mar 31. Epub 2022 Mar 31.

Division of Pediatrics, Israel; Barzilai Medical Center, Israel; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address:

Background: To compare the epidemiologic, microbiologic and imaging characteristics of urinary tract infections (UTI) in children <2 years of age with and without anatomic urinary tract abnormalities (AA).

Methods: All children hospitalized with UTI during 1.1. Read More

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Microbiota and HPV: The role of viral infection on vaginal microbiota.

J Med Virol 2022 May 8. Epub 2022 May 8.

Section of Microbiology and Virology, University Hospital "Luigi Vanvitelli", Naples, Italy.

The World Health Organization (WHO) estimates that the prevalence of human papillomaviruses (HPV) infection is between 9% and 13% of the world population and only in the United States, more than 6.2 million are positive every year. There are more than 100 types of HPV, among them, two serotypes (16 and 18) are related to 70% of cervical cancers and precancerous cervical lesions. Read More

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The Bacterial Profile and Antimicrobial Susceptibility Patterns of Urinary Tract Infection Patients at Pawe General Hospital, Northwest Ethiopia.

Scientifica (Cairo) 2022 25;2022:3085950. Epub 2022 Apr 25.

Department of Biology, College of Natural and Computational Science, Mekdela Amba University, P.O. Box 32, Tuluawlia, Ethiopia.

Urinary tract infection remains the most common infection widespread worldwide in both community and hospital settings. Rapidly increasing antibiotic resistance of uropathogens is resulting in limited treatment options. Thus, understanding the current uropathogens and their antimicrobial susceptibilities is essential for effective urinary tract infection treatment. Read More

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Rational Development of Bacterial Ureases Inhibitors.

Chem Rec 2022 May 3:e202200026. Epub 2022 May 3.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.

Urease, an enzyme that catalyzes the hydrolysis of urea, is a virulence factor of various pathogenic bacteria. In particular, Helicobacter pylori, that colonizes the digestive tract and Proteus spp., that can infect the urinary tract, are related to urease activity. Read More

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Multivalvular infective endocarditis with Proteus mirabilis.

IDCases 2022 28;27:e01429. Epub 2022 Jan 28.

Department of Infectious Disease, Staten Island University Hospital, Staten Island, NY, USA.

Proteus species belong to the Enterobacteriaceae family and are gram-negative-rods, commonly known to cause urinary tract infections and asymptomatic bacteriuria in elderly patients with risk factors such as diabetes mellitus and urinary catheterization. However, Proteus species are rarely known to cause infective endocarditis. We present a case of an 85-year-old female who presented due to decreased responsiveness with urine and blood cultures growing . Read More

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January 2022

Design, preparation, and characterization of CS/PVA/SA hydrogels modified with mesoporous AgO/SiO and curcumin nanoparticles for green, biocompatible, and antibacterial biopolymer film.

RSC Adv 2021 Oct 6;11(52):32775-32791. Epub 2021 Oct 6.

Department of Organic Chemistry, Faculty of Chemistry, University of Kashan P.O. Box 87317-53153 Kashan Iran.

One of the most significant factors affecting the rapid and effective healing of wounds is the application of appropriate wound dressings. In the present study, novel antibacterial wound dressings are fabricated that consist of Chitosan (CS)/Polyvinyl alcohol (PVA)/Sodium Alginate (SA), which are all biocompatible, functionalized with mesoporous AgO/SiO and curcumin nanoparticles as reinforcements. In this research nanocomposites are fabricated (0 wt%, 5 wt%, 10 wt%, 15 wt%, and 20 wt% of AgO/SiO). Read More

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October 2021