6,670 results match your criteria Proteus Infections


Monitoring the antimicrobial susceptibility of Gram-negative organisms involved in intraabdominal and urinary tract infections recovered during the SMART study (Spain, 2016 and 2017).

Rev Esp Quimioter 2019 Feb 13. Epub 2019 Feb 13.

Rafael Cantón. Servicio de Microbiología. Hospital Universitario Ramón y Cajal. Carretera de Colmenar Km 9,1. 28034 Madrid. Spain.

Objective: Continuous antimicrobial resistance surveillance is recommended by Public Health authorities. We up-dated data from the SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study in Spain.

Methods: The antimicrobial susceptibility data and extended-spectrum beta-lactamase (ESBL) production in isolates recovered from intra-abdominal (IAI) (n=1,429) and urinary tract (UTI) (n=937) infections during the 2016- 2017 SMART study in 10 Spanish hospitals were analysed. Read More

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February 2019

Orthopedic Implant-Associated Infection by Multidrug Resistant .

J Clin Med 2019 Feb 8;8(2). Epub 2019 Feb 8.

Department of Clinical Microbiology, Hospital Universitario Fundación Jiménez Díaz. IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain.

Introduction: Orthopedic implant-associated infections caused by multidrug-resistant are a growing challenge for healthcare providers due to their increasing incidence and the difficulties of medical and surgical treatment.

Material And Methods: A retrospective observational study of all cases of multidrug resistant orthopedic implant-associated infection diagnosed in a tertiary European hospital from December 2011 to November 2017 was carried out. Clinical records were reviewed using a previously designed protocol. Read More

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http://dx.doi.org/10.3390/jcm8020220DOI Listing
February 2019
1 Read

Quercetin inhibits swarming motility and activates biofilm production of Proteus mirabilis possibly by interacting with central regulators, metabolic status or active pump proteins.

Phytomedicine 2018 Dec 11;57:65-71. Epub 2018 Dec 11.

Ege University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, İzmir 35040, Turkey.

Background: Via its virulence factors such as swarm differentiation, biofilm and hemolysin production, urease enzyme, Proteus mirabilis causes urinary tract infections (UTIs), especially in complicated cases. Anti-pathogenic compounds attenuate the virulence of bacteria without showing 'cidal' activity and carry the potential to be used in the prevention and treatment of infectious diseases.

Purpose: Search for anti-pathogenic effects of quercetin, which is a widely known and biologically active phytochemical, on Proteus mirabilis was the purpose of this study. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.014DOI Listing
December 2018

In vitro activity of Plazomicin against Enterobacteriaceae isolates carrying genes encoding aminoglycoside-modifying enzymes most common in US Census divisions.

Diagn Microbiol Infect Dis 2018 Dec 5. Epub 2018 Dec 5.

JMI Laboratories, North Liberty, IA 52317.

Aminoglycoside-nonsusceptible isolates of Escherichia coli, Klebsiella, Proteus, and Enterobacter species (480/3675) from US hospitals collected during 2014-2015 were screened for 16S rRNA methyltransferase and aminoglycoside-modifying enzyme (AME) genes. Only 5 isolates had high aminoglycoside MICs and carried 16S rRNA methyltransferases. AME genes were observed among 89. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.023DOI Listing
December 2018
2 Reads

Using the wax moth larva infection model to detect emerging bacterial pathogens.

PeerJ 2019 4;6:e6150. Epub 2019 Jan 4.

European Centre for Environment and Human Health, University of Exeter, Penryn, UK.

Climate change, changing farming practices, social and demographic changes and rising levels of antibiotic resistance are likely to lead to future increases in opportunistic bacterial infections that are more difficult to treat. Uncovering the prevalence and identity of pathogenic bacteria in the environment is key to assessing transmission risks. We describe the first use of the Wax moth larva , a well-established model for the mammalian innate immune system, to selectively enrich and characterize pathogens from coastal environments in the South West of the UK. Read More

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https://peerj.com/articles/6150
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http://dx.doi.org/10.7717/peerj.6150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322482PMC
January 2019
4 Reads

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.

J Antimicrob Chemother 2019 Jan 9. Epub 2019 Jan 9.

Institute of Medical Microbiology, University of Zürich, Gloriastrasse 30, CH-8006 Zürich, Switzerland.

Objectives: Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects. Apramycin, an aminoglycoside antibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in carbapenemase-producing clinical isolates. This study evaluates the in vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii, and provides a rationale for its superior antibacterial activity in the presence of aminoglycoside resistance determinants. Read More

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https://academic.oup.com/jac/advance-article/doi/10.1093/jac
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http://dx.doi.org/10.1093/jac/dky546DOI Listing
January 2019
10 Reads

Induction of Different Apoptosis Pathways by Two Clinical Isolates Strains in Prostatic Epithelial Cells.

Front Physiol 2018 20;9:1855. Epub 2018 Dec 20.

Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania Luigi Vanvitelli, Naples, Italy.

Bacterial prostatitis is believed to be the leading cause of recurrent urinary tract infections (UTIs) in men under 50 years of age and occurs both as an acute febrile disease responsive to antibiotics and as a chronic infection that is often unresponsive to antibiotic treatment. is more commonly associated with UTIs in these abnormalities, especially in patients undergoing catheterisation. This pathogen is able to colonise the host's tissues and to cause disease thanks to the production of many virulence factors such as fimbriae, flagella, immune avoidance, host-damaging factors, and the ability to form crystalline biofilms. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01855
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http://dx.doi.org/10.3389/fphys.2018.01855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306403PMC
December 2018
4 Reads

Susceptibility patterns of uropathogens identified in hospitalized children.

Pediatr Int 2018 Dec 28. Epub 2018 Dec 28.

Department of Pediatrics, Venizeleion General Hospital, Heraklion, Crete, Greece.

Background: Urinary tract infection (UTI) is the most common serious bacterial infection in childhood.

Aim Of The Study: The aim of the present study was to identify the organisms responsible for community acquired febrile UTI in children, to investigate their susceptibility to commonly used antibiotics and identify possible risk factors for antibiotic resistance.

Methods: A total of 284 children, 38% males and 62% females, who were hospitalized due to a community-acquired UTI over a 5-year period in a general district hospital of Southern Greece, were enrolled in the study. Read More

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http://doi.wiley.com/10.1111/ped.13772
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http://dx.doi.org/10.1111/ped.13772DOI Listing
December 2018
10 Reads
0.731 Impact Factor

Clonal relatedness of Proteus mirabilis strains causing urinary tract infections in companion animals and humans.

Vet Microbiol 2019 Jan 22;228:77-82. Epub 2018 Oct 22.

Interdisciplinary Centre of Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477, Lisboa, Portugal. Electronic address:

Proteus mirabilis is a major cause of urinary tract infection (UTI) in humans and companion animals. This study aimed to evaluate the antimicrobial resistance, virulence and clonal relatedness of P. mirabilis isolated from dogs, cats and humans with UTI. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.10.015DOI Listing
January 2019
1 Read

Unexpected source of bacteraemia.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of General Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Mycotic (infected) aneurysm involving the thoracic aorta is an exceedingly rare and life-threatening condition that is associated with high morbidity and mortality. We report an unusual source of bacteraemia thought to be due to an infected aneurysm in the thoracic aortic arch in an elderly woman. Source of gram-negative bacteraemia is usually isolated to an intra-abdominal or a pelvic source. Read More

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http://dx.doi.org/10.1136/bcr-2018-226744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301452PMC
December 2018
5 Reads

Asymptomatic Bacteriuria and Anti-Microbial Susceptibility Patterns among Women of Reproductive Age. A Cross-Sectional Study in Primary Care, Ghana.

Med Sci (Basel) 2018 Dec 17;6(4). Epub 2018 Dec 17.

Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi, Ghana.

Asymptomatic bacteriuria (ASB) poses serious future clinical repercussions for reproductive women. The study determined the prevalence of asymptomatic bacteriuria along with anti-microbial susceptibility patterns among women of reproductive age in a primary care facility. The study recruited a total of 300 women of reproductive age attending the Tetteh Quarshie Memorial Hospital at Akuapem-Mampong, Ghana, between January and March 2018. Read More

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http://dx.doi.org/10.3390/medsci6040118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313490PMC
December 2018

Prevalence of metallo-β-lactamase acquired genes among carbapenems susceptible and resistant Gram-negative clinical isolates using multiplex PCR, Khartoum hospitals, Khartoum Sudan.

BMC Infect Dis 2018 Dec 17;18(1):668. Epub 2018 Dec 17.

Medical Microbiology Department, Faculty of Medical Laboratory Science, Al Neelain University, Khartoum, Sudan.

Background: The increased prevalence of carbapenem-resistant Gram-negative isolates caused by Metallo-β-lactamase (MBL) is worrisome in clinical settings worldwide. The mortality rate associated with infections caused by MBLs producing organisms ranging from 18 to 67%. This study aimed to determine the prevalence of Metallo-β-lactamase genes among some Gram-negative clinical isolates (Carbapenems susceptible and resistant). Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3581-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296134PMC
December 2018
7 Reads

First prevalence of metallo beta-lactamases producing Enterobacteriacea in Iranian cancer patients.

Authors:
D Zare H Fazeli

Ann Ig 2019 Jan-Feb;31(1):62-68

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Hospital-associated infections, recently renamed Healthcare-associated infections, are among the most common life-threatening complications of hospitalized patients, especially the immunocompromised patients. Regarding the significant role of Enterobacteriaceae in nosocomial infections and also the increasing trends of carbapenem-resistant strains, the present study aimed to evaluate the antibiotic resistance pattern and the occurrence of metallo-beta-lactamases (MBLs) in Enterobacteriaceae strains from Iranian cancer patients.

Methods: This hospital-based cross-sectional study was conducted in teaching hospitals of two cities in the central parts of Iran during the 6 months period from December 2015 to May 2016. Read More

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http://dx.doi.org/10.7416/ai.2019.2259DOI Listing
December 2018
9 Reads

Primary and Secondary Bacteremia Caused by spp.: Epidemiology, Strains Susceptibility and Biofilm Formation.

Pol J Microbiol 2018 ;67(4):471-478

Department of Microbiology, Nicolaus Copernicus University in Toruń, L. Rydygier Collegium Medicum in Bydgoszcz , Poland.

Proteus spp. is an etiological factor of urinary tract and bloodstream infections. The aim of this study was the retrospective analysis of susceptibility of Proteus spp. Read More

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http://dx.doi.org/10.21307/pjm-2018-055DOI Listing
January 2018

In vitro antimicrobial activity of seven adjuvants against common pathogens associated with canine otitis externa.

Vet Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, 5371, Australia.

Background: An antibiotic adjuvant is a chemical substance used to modify or augment the effectiveness of primary antimicrobial agents against drug-resistant micro-organisms. Its use provides an alternative approach to address the global issue of antimicrobial resistance and enhance antimicrobial stewardship.

Hypothesis/objectives: To determine the antimicrobial activity of a panel of potential antimicrobial adjuvants against common pathogens associated with canine otitis externa (OE). Read More

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http://dx.doi.org/10.1111/vde.12712DOI Listing
December 2018
2 Reads
1.732 Impact Factor

[Surveillance of resistance in the intensive care units using a cumulative antibiogram].

Mikrobiyol Bul 2018 Oct;52(4):329-339

Haydarpaşa Numune Training and Research Hospital, Department of Medical Microbiology, Istanbul, Turkey.

Empiric treatment with broad-spectrum antibiotics exerts condensed pressure in intensive care units (ICUs) for the selection of multidrug-resistant bacteria. Multidrug-resistant gram-negative bacteria became the focus of interest owing to limited treatment options and negative effects on patient survival. Cumulative antibiograms can guide selection of correct empiric treatment, de-escalation treatment according to antibiogram results and development of policies in fight against antibiotic resistance. Read More

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http://dx.doi.org/10.5578/mb.67408DOI Listing
October 2018
2 Reads

Epidemiology of Early-onset Bacterial Neonatal Infections in Madagascar.

Pediatr Infect Dis J 2019 Jan;38(1):76-81

Association Jeremi Rhône-Alpes, Lyon, France.

Background: Little is known about early-onset neonatal bacterial infections (EONBI) in Madagascar. Our aim was to determine their epidemiology to improve their management.

Methods: Inborn neonates at risk for EONBI and admitted in the neonatal unit of 2 tertiary hospitals in Antananarivo, Madagascar, were included in a prospective study from April 2012 to March 2013. Read More

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http://dx.doi.org/10.1097/INF.0000000000001993DOI Listing
January 2019
5 Reads

Influence of various uropathogens on crystallization of urine mineral components caused by Proteus mirabilis.

Res Microbiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Biology of Bacteria, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. Electronic address:

Infectious urolithiasis is a consequence of long-standing urinary tract infections with urease-positive bacteria, especially Proteus spp. However, because of the often mixed nature of urinary tract infections, in the case of urinary stones formation, several species of bacteria may be involved in the process. The purpose of the study was to determine the impact of the bacterial species: Escherichia coli, Klebsiella pneumoniae, Providencia stuartii, Pseudomonas aeruginosa and Staphylococcus aureus on the crystallization caused by Proteus mirabilis. Read More

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http://dx.doi.org/10.1016/j.resmic.2018.11.005DOI Listing
December 2018
3 Reads

SuperPolymyxin™ Medium for the Screening of Colistin-Resistant Gram-Negative Bacteria in Stool Samples.

Front Microbiol 2018 21;9:2809. Epub 2018 Nov 21.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Colistin is one of the last resort antimicrobials for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. After the emergence of transferable colistin resistance genes (-1-5), a reliable culture-based screening method to detect colonization with colistin-resistant Gram-negative bacteria (CRGN) is needed. The objective of this study was to test the performance of SuperPolymyxin™ medium to screen for CRGN in stool samples and to compare different methods for the confirmation of colistin resistance (e. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258816PMC
November 2018
1 Read

Antibiotic resistance of Enterobacteriaceae causing urinary tract infections in elderly patients living in the community and in the nursing home: a retrospective observational study.

J Antimicrob Chemother 2019 Mar;74(3):775-781

Université de Lorraine, APEMAC, Nancy, France.

Objectives: Although nursing homes are thought to be significant reservoirs of antibiotic-resistant bacteria, very few large population-based studies comparing antibiotic resistance prevalence in nursing homes and in the community have adjusted for patient characteristics. Our objective was to compare the prevalence of antibiotic resistance of Enterobacteriaceae cultured from urine samples of nursing home residents with that of community-dwelling adults, all aged 65 years or older.

Methods: This study analysed around 20 000 positive urine samples sent to a large laboratory in north-eastern France from 2014 to 2017, collected from individuals aged 65 years or older. Read More

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http://dx.doi.org/10.1093/jac/dky488DOI Listing
March 2019
1 Read

Emerging antimicrobial resistance among strains in bloodstream infections in Toronto, 2006-2016: a retrospective cohort study.

CMAJ Open 2018 Oct-Dec;6(4):E580-E586. Epub 2018 Dec 3.

Department of Microbiology (Mineau, Kozak, Kissoon, Paterson, Oppedisano, Douri, Gogan, Willey, McGeer, Poutanen), University Health Network/Sinai Health System, Toronto, Ont.; Centre intégré de santé et de services sociaux de Chaudière-Appalaches (Mineau), Sainte-Marie, Que.; Lawrence Park Collegiate Institute (Gogan); Departments of Laboratory Medicine and Pathobiology and of Medicine (McGeer, Poutanen), University of Toronto, Toronto, Ont.

Background: Enterobacteriaceae that produce extended-spectrum β-lactamase (ESBL) have emerged as a serious threat, with variable rates depending on geographic region. We determined the prevalence of ESBL-producing , , and in bloodstream infections in Toronto from 2006 through 2016.

Methods: All patients with , , and isolated from blood in a tertiary care microbiology laboratory in Toronto between 2006 and 2016 (1 isolate per species per patient per year) were included in this retrospective cohort study. Read More

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http://cmajopen.ca/lookup/doi/10.9778/cmajo.20180039
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http://dx.doi.org/10.9778/cmajo.20180039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277254PMC
December 2018
2 Reads

Laboratory Diagnosis of Bacterial Vaginosis and Potential Pathogens Other Than Group B Streptococcus in Vaginal Swab of Pregnant Women in Dhaka Medical College Hospital.

Mymensingh Med J 2018 Oct;27(4):834-842

Dr Mst Naznin Tarana, Research Student, Department of Microbiology, Dhaka Medical College, Dhaka, Bangladesh; E-mail:

Pathogenic microorganisms are important cause of maternal and neonatal infections which are transmitted from colonized vagina of mother. The purpose of the present study was to detect the potential pathogens other than Group B Streptococcus in vaginal swab of pregnant women. This prospective cross sectional study was conducted from July 2013 to June 2014 at Dhaka Medical College Hospital, Dhaka, Bangladesh. Read More

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October 2018
3 Reads

The correlation of crystalline and elemental composition of urinary stones with a history of bacterial infections: TXRF, XRPD and PCR-DGGE studies.

Eur Biophys J 2019 Jan 27;48(1):111-118. Epub 2018 Nov 27.

2nd Department of Urology, Medical University of Lodz, Pabianicka St. 62, 93-513, Łódź, Poland.

The aim of this study was to analyze the correlation between past bacterial infections and the type and chemical composition of urinary stones experienced by human patients. Bacteria have been recognized to contribute to urinary stones; however, the role of uropathogens in the development of specific stones has not been extensively investigated. The detection of past bacterial infection (eleven different bacterial species) in urinary stones from 83 patients was made on a DNA level using polymerase chain reaction (PCR) and denaturing gradient gel electrophoresis (DGGE) and correlated with the chemical composition of urinary stones measured using X-ray powder diffraction (XPRD) technique and their elemental composition by total reflection X-ray fluorescence (TXRF). Read More

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http://dx.doi.org/10.1007/s00249-018-1338-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330562PMC
January 2019
8 Reads

Polymerase Chain Reaction Assay Using the Restriction Fragment Length Polymorphism Technique in the Detection of Prosthetic Joint Infections: A Multi-Centered Study.

J Arthroplasty 2019 Feb 25;34(2):359-364. Epub 2018 Oct 25.

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Behshti University of Medical Sciences, Tehran, Iran; Department of Molecular Biology, Dr. Khosroshahi's Pathobiology Laboratory, Tehran, Iran.

Background: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method.

Methods: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study. Read More

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http://dx.doi.org/10.1016/j.arth.2018.10.017DOI Listing
February 2019
2 Reads

Prevalence and associated factors of urinary tract infections among diabetic patients in Arba Minch Hospital, Arba Minch province, South Ethiopia.

Turk J Urol 2018 Nov 21;45(1):56-62. Epub 2018 Nov 21.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Objective: Urinary tract infection (UTI) is a common and grave health problem in the world. In fact, patients with diabetes mellitus have an immense risk for developing UTI. The development of resistance among uropathogens to antibiotics is a major crisis which limits the use of drug of choice for the treatment of UTI. Read More

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http://dx.doi.org/10.5152/tud.2018.32855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342569PMC
November 2018
1 Read

The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.

Microb Genom 2018 Nov 21;4(11). Epub 2018 Nov 21.

1​Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.

Carbapenem resistance is a rapidly growing threat to our ability to treat refractory bacterial infections. To understand how carbapenem resistance is mobilized and spread between pathogens, it is important to study the genetic context of the underlying resistance mechanisms. In this study, the resistomes of six clinical carbapenem-resistant isolates of five different species - Acinetobacter baumannii, Escherichia coli, two Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa - were characterized using whole genome sequencing. Read More

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http://dx.doi.org/10.1099/mgen.0.000233DOI Listing
November 2018
15 Reads

Antimicrobial susceptibilities of specific syndromes created with organ-specific weighted incidence antibiograms (OSWIA) in patients with intra-abdominal infections.

BMC Infect Dis 2018 Nov 19;18(1):584. Epub 2018 Nov 19.

Department of Hospital Infection Control, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Rui-Jin 2nd Road, Shanghai, 200025, China.

Background: The aim was to evaluate the value of organ-specific weighted incidence antibiogram (OSWIA) percentages for bacterial susceptibilities of Gram-negative bacteria (GNB) collected from intra-abdominal infections (IAIs) during SMART 2010-2014.

Methods: We retrospectively calculated the OSWIA percentages that would have been adequately covered by 12 common antimicrobials based on the bacterial compositions found in the appendix, peritoneum, colon, liver, gall bladder and pancreas.

Results: The ESBL positive rates were 65. Read More

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http://dx.doi.org/10.1186/s12879-018-3494-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245934PMC
November 2018
8 Reads

Nitroxoline: an option for the treatment of urinary tract infection with multi-resistant uropathogenic bacteria.

Infection 2018 Nov 17. Epub 2018 Nov 17.

Department of Pneumology, Theresienkrankenhaus, Bassermannstr. 1, 68165, Mannheim, Germany.

The number of multi-resistant uropathogens is increasing. A multi-morbid patient developed a symptomatic urinary tract infection with two multi-resistant bacteria, namely Klebsiella pneumoniae and Proteus mirabilis. Nitroxoline was the only drug active against both uropathogens. Read More

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http://link.springer.com/10.1007/s15010-018-1253-y
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http://dx.doi.org/10.1007/s15010-018-1253-yDOI Listing
November 2018
6 Reads

Draft Genome Sequences of Proteus mirabilis K1609 and K670: A Model Strains for Territoriality Examination.

Curr Microbiol 2019 Feb 17;76(2):144-152. Epub 2018 Nov 17.

Department of Microbiology, Jan Kochanowski University, 15 Swietokrzyska Street, 25-406, Kielce, Poland.

Proteus mirabilis is a pathogenic Gram-negative bacterium characterized by its ability to swarm across surfaces, which frequently leads to colonization of the urinary tract and causes severe infections. P. mirabilis strains are also well known from their self-recognition phenomenon, referred to as Dienes phenomenon. Read More

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http://dx.doi.org/10.1007/s00284-018-1598-6DOI Listing
February 2019

Identification of small molecule compounds active against Staphylococcus aureus and Proteus mirabilis.

Biochem Biophys Res Commun 2018 Dec 5;506(4):1047-1051. Epub 2018 Nov 5.

Institute of Immunology and Experimental Therapy of the Polish Academy of Science, Department of Immunology of Infectious Diseases, ul. R. Weigla 12, 53-114, Wroclaw, Poland.

Staphylococcus aureus is a human pathogen rapidly becoming a serious health problem due to ease of acquiring antibiotic resistance. To help identify potential new drug candidates effective against the pathogen, a small focused library was screened for inhibition of bacterial growth against several pathogens, including S. aureus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183237
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http://dx.doi.org/10.1016/j.bbrc.2018.10.189DOI Listing
December 2018
10 Reads

The antibacterial effect of peritoneal fluid in experimental peritonitis.

Ulus Travma Acil Cerrahi Derg 2018 Sep;24(5):387-390

Department of General Surgery, University of Health Sciences, İstanbul Fatih Sultan Mehmet Training and Research Hospital, İstanbul-Turkey.

Background: In our study, the effects of peritoneal fluid on some Gram-negative and Candida albicans in experimental peritonitis rats were studied. The primary objective of the present study was to understand the effect of peritoneal fluid on microorganisms causing intra-abdominal infections.

Methods: Twenty male Sprague-Dawley rats weighing between 250 and 300 g were used in the study. Read More

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http://dx.doi.org/10.5505/tjtes.2018.10452DOI Listing
September 2018
9 Reads

Structures of two fimbrial adhesins, AtfE and UcaD, from the uropathogen Proteus mirabilis.

Acta Crystallogr D Struct Biol 2018 Nov 29;74(Pt 11):1053-1062. Epub 2018 Oct 29.

Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, PO Box 596, SE-751 24 Uppsala, Sweden.

The important uropathogen Proteus mirabilis encodes a record number of chaperone/usher-pathway adhesive fimbriae. Such fimbriae, which are used for adhesion to cell surfaces/tissues and for biofilm formation, are typically important virulence factors in bacterial pathogenesis. Here, the structures of the receptor-binding domains of the tip-located two-domain adhesins UcaD (1. Read More

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http://dx.doi.org/10.1107/S2059798318012391DOI Listing
November 2018
1 Read

Prevalence and Antimicrobial Susceptibility of Bacterial Uropathogens Isolated from Pediatric Patients at Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia.

Int J Microbiol 2018 2;2018:8492309. Epub 2018 Oct 2.

Addis Ababa University, College of Health Sciences, Department of Medical Laboratory Sciences, Addis Ababa, Ethiopia.

Background: Urinary tract infection (UTI) is considered as the most common bacterial infection seen among the pediatric patients.

Objective: This study was carried out in order to determine the prevalence of urinary tract infection in pediatric patients, identify bacterial uropathogens responsible for the infection, and study the antibiotic sensitivity patterns of bacterial isolates.

Materials And Methods: A cross-sectional study designed and conducted from January to April 2014. Read More

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http://dx.doi.org/10.1155/2018/8492309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189692PMC
October 2018
1 Read

In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A.

Sci Transl Med 2018 Oct;10(464)

EPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

Respiratory infections in mechanically ventilated patients caused by Gram-negative bacteria are a major cause of morbidity. Rapid and unequivocal determination of the presence, localization, and abundance of bacteria is critical for positive resolution of the infections and could be used for patient stratification and for monitoring treatment efficacy. Here, we developed an in situ approach to visualize Gram-negative bacterial species and cellular infiltrates in distal human lungs in real time. Read More

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http://dx.doi.org/10.1126/scitranslmed.aal0033DOI Listing
October 2018
1 Read

Synthesis of terpenoid oxo derivatives with antiureolytic activity.

Mol Biol Rep 2018 Oct 22. Epub 2018 Oct 22.

Bioorganic Chemistry Department, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.

Urease is an important virulence factor for a variety of pathogenic bacteria strains such as Helicobacter pylori, which colonizes human gastric mucosa, and Proteus sp., responsible for urinary tract infections. Specific inhibition of urease activity could be a promising adjuvant strategy for eradication of these pathogens. Read More

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http://link.springer.com/10.1007/s11033-018-4442-y
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http://dx.doi.org/10.1007/s11033-018-4442-yDOI Listing
October 2018
11 Reads

Prevalence, antimicrobial susceptibility profile and predictors of asymptomatic bacteriuria among pregnant women in Adigrat General Hospital, Northern Ethiopia.

BMC Res Notes 2018 Oct 19;11(1):740. Epub 2018 Oct 19.

Department of Medical Microbiology, Immunology and Parasitology, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Objective: Approach to asymptomatic bacteriuria among pregnant women in Ethiopia is mainly based on clinical grounds and urine strip and microscopy tests. On top of this, the treatment is also on an empirical basis which may leads to an increased antimicrobial resistance. The aim of this study was to assess the prevalence, antimicrobial susceptibility profile and associated factors of asymptomatic bacteriuria among pregnant women attending antenatal clinic in Adigrat Hospital, Northern Ethiopia. Read More

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http://dx.doi.org/10.1186/s13104-018-3844-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194591PMC
October 2018
2 Reads

Prevalence of methicillin resistant , multidrug resistant and extended spectrum β-lactamase producing gram negative bacilli causing wound infections at a tertiary care hospital of Nepal.

Antimicrob Resist Infect Control 2018 8;7:121. Epub 2018 Oct 8.

1Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal.

Background: Treatment and prevention of wound infection continues to be a challenging issue in clinical settings of Nepal especially in the context of globally growing problem of antimicrobial resistance. Study on opportunistic pathogens and sensitivity to commonly prescribed local antimicrobial agents are cardinal to reduce the disease burden of wound infections. The aim of this study was to determine the prevalence and antimicrobial susceptibility pattern of methicillin resistant (MRSA) and extended spectrum β-lactamase (ESBL) producing bacteria from wound infections of patients at a tertiary care hospital in Nepal. Read More

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https://aricjournal.biomedcentral.com/articles/10.1186/s1375
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http://dx.doi.org/10.1186/s13756-018-0408-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174564PMC
October 2018
11 Reads

Urinary tract infections in febrile children: Changing spectra of pathogenic bacteria and antibiotic susceptibilities?

J Paediatr Child Health 2018 Oct 15. Epub 2018 Oct 15.

Department of General Medicine, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Aim: To compare the spectra of pathogens causing febrile urinary tract infections (UTI) in children, treatment and antimicrobial susceptibility between 2004-2006 and 2007-2009.

Methods: UTI were identified from a cohort study of febrile children younger than 5 years presenting to a large tertiary children's hospital's emergency department with febrile illnesses. We compared pathogenic profiles, antibiotic choices and susceptibilities between 2004-2006 and 2007-2009 and tested for differences using χ and Fisher's exact tests. Read More

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http://dx.doi.org/10.1111/jpc.14275DOI Listing
October 2018
8 Reads

Antibiotic susceptibility profile of bacterial isolates from post-surgical wounds of patients in tertiary care hospitals of Peshawar, Pakistan.

J Pak Med Assoc 2018 Oct;68(10):1517-1521

Department of Biochemistry, Hazara University, Mansehra, Pakistan.

Postoperative wound infections are the infections of the operating site within thirty days after surgery. The infections that develop after surgery are a major problem throughout the world leading to, increased morbidity and mortality. This study was carried out to determine the prevalence of bacterial pathogens causing wound infection in the surgical wards and to determine the antimicrobial sensitivity patterns of the isolated bacteria. Read More

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October 2018
2 Reads
0.403 Impact Factor

Outpatient Antibiotic Consumption for Urinary Infections in Croatia 2005 - 2014: What can be Learned from Utilization Trends.

Zdr Varst 2018 Dec 1;57(4):183-191. Epub 2018 Oct 1.

Ordinacija obiteljske medicine "Daus Šebeđak Danijela, dr med" Podvinje, Slavonski Brod, Croatia.

Aim: The aim of this study was to determine quantities of antibiotics used mainly or exclusively for urinary tract infections in Croatia between 2005 and 2014, to describe utilisation trends, and general consequences of antibiotic consumption on antimicrobial resistance.

Methods: Antibiotic utilisation data were obtained from annual reports of both the Croatian Drug Agency and Croatian Academy of Medical Sciences. Antibiotic consumption was expressed in DDD/1000 inhabitants/day (DDD TID). Read More

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http://content.sciendo.com/view/journals/sjph/57/4/article-p
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http://dx.doi.org/10.2478/sjph-2018-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172528PMC
December 2018
1 Read

Bacteriophage ZCKP1: A Potential Treatment for Isolated From Diabetic Foot Patients.

Front Microbiol 2018 11;9:2127. Epub 2018 Sep 11.

Biomedical Sciences, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt.

The recorded growth in infection by multidrug resistant bacteria necessitates prompt efforts toward developing alternatives to antibiotics, such as bacteriophage therapy. Immuno-compromised patients with diabetes mellitus are particularly prone to foot infections by multidrug resistant , which may be compounded by chronic osteomyelitis. Bacteriophage ZCKP1, isolated from freshwater in Giza, Egypt, was tested to evaluate its lytic activity against a multidrug resistant KP/01, isolated from foot wound of a diabetic patient in Egypt. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02127
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http://dx.doi.org/10.3389/fmicb.2018.02127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141743PMC
September 2018
9 Reads

Urinary tract infection control in intensive care patients.

Medicine (Baltimore) 2018 Sep;97(38):e12195

Department of Critical Care Medicine, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China.

This retrospective study tried to find the potential approach for reducing the urinary tract infection (UTI) in intensive care patients (ICPs) among adult population.In total, 96 eligible ICP cases were included. Of these, 48 cases received 10% povidone-iodine and were assigned to the intervention group, while the other 48 cases underwent sterile water, and were assigned to the control group for the prevention of catheter-associated UTI before indwelling urinary catheter insertion in ICP. Read More

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http://dx.doi.org/10.1097/MD.0000000000012195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160021PMC
September 2018
2 Reads

Prevalence of Multidrug-Resistant Isolated from Drinking Water Sources.

Int J Microbiol 2018 19;2018:7204013. Epub 2018 Aug 19.

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

The control of infectious diseases is badly endangered by the rise in the number of microorganisms that are resistant to antimicrobial agents. This is because infections caused by resistant microorganisms often fail to respond to conventional treatment, resulting in prolonged illness and greater risk of death. Antimicrobial-resistant bacteria are also present in various water sources. Read More

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https://www.hindawi.com/journals/ijmicro/2018/7204013/
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http://dx.doi.org/10.1155/2018/7204013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120285PMC
August 2018
18 Reads

Phenotypic screening and molecular characterization of carbapenemase-producing Gram-negative bacilli recovered from febrile neutropenic pediatric cancer patients in Egypt.

PLoS One 2018 29;13(8):e0202119. Epub 2018 Aug 29.

Department of Microbiology & Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Aim: Infections with carbapenem-resistant Gram-negative bacteria (GNB) are among the most frequent complications in the immunocompromised cancer patients because of their considerable morbidity and mortality. Therefore, the aim of the current study was to characterize the prevalence of carbapenemase-producing GNB recovered from febrile neutropenic pediatric cancer patients in Egypt.

Methods: Standard methods were used for identification, sensitivity testing (Kirby-Bauer and broth microdilution method according to CLSI guidelines). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202119PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114715PMC
January 2019
8 Reads

Exploring the Microbiota of Diabetic Foot Infections With Culturomics.

Front Cell Infect Microbiol 2018 14;8:282. Epub 2018 Aug 14.

MEPHI, APHM, IRD, Aix Marseille University, IHU-Méditerranée Infection, Marseille, France.

The purpose of this prospective observational study was to evaluate the richness and diversity of bacteria in samples from diabetic foot infections using a culturomics approach. Bacterial culture findings from wound samples were analyzed together with clinical characteristics and treatment outcomes. We included 43 patients admitted to a French referral center with a moderate to severe diabetic foot infection. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102383PMC
August 2018
6 Reads

Pattern of Infecting Microorganisms and Their Susceptibility to Antimicrobial Drugs in Patients with Diabetic Foot Infections in a Tertiary Care Hospital in Karachi, Pakistan.

Cureus 2018 Jun 25;10(6):e2872. Epub 2018 Jun 25.

Surgery, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Diabetes mellitus is a universal health problem, with its prevalence in Pakistan making it among the top 10 countries in the world. Approximately 13.9 million people in Pakistan will have developed diabetes by 2030. Read More

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http://dx.doi.org/10.7759/cureus.2872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110415PMC
June 2018
4 Reads

Genomic analyses of a novel bacteriophage (VB_PmiS-Isfahan) within Siphoviridae family infecting Proteus mirabilis.

Genomics 2018 Aug 24. Epub 2018 Aug 24.

Laboratory Sciences Research Center, Golestan University of Medical Sciences, 4934174515 Gorgan, Iran. Electronic address:

Proteus mirabilis is one of the most common causes of complicated urinary tract infections (UTI), especially in catheter-associated UTIs. The increased resistance to antibiotics, among P. mirabilis isolates has led us to search for alternative antibacterial agents. Read More

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http://dx.doi.org/10.1016/j.ygeno.2018.08.008DOI Listing
August 2018
16 Reads

Identification of the Indispensable Quorum Sensing Proteins of Multidrug Resistant .

Front Cell Infect Microbiol 2018 7;8:269. Epub 2018 Aug 7.

Department of Biological Sciences, Sunway University, Petaling Jaya, Malaysia.

Catheter-associated urinary tract infections (CAUTI) is an alarming hospital based disease with the increase of multidrug resistance (MDR) strains of . Cases of long term hospitalized patients with multiple episodes of antibiotic treatments along with urinary tract obstruction and/or undergoing catheterization have been reported to be associated with CAUTI. The cases are complicated due to the opportunist approach of the pathogen having robust swimming and swarming capability. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090301PMC
August 2018
22 Reads

Adapted Bacteriophages for Treating Urinary Tract Infections.

Front Microbiol 2018 7;9:1832. Epub 2018 Aug 7.

Department of Neuro-Urology, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Urinary tract infections (UTIs) are among the most widespread microbial diseases and their economic impact on the society is substantial. The continuing increase of antibiotic resistance worldwide is worrying. As a consequence, well-tolerated, highly effective therapeutic alternatives are without delay needed. Read More

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http://dx.doi.org/10.3389/fmicb.2018.01832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090023PMC
August 2018
17 Reads