59,059 results match your criteria Proteinuria


Alterations of Renal Epithelial Glucose and Uric Acid Transporters in Fructose Induced Metabolic Syndrome.

Kidney Blood Press Res 2018 Dec 7;43(6):1822-1831. Epub 2018 Dec 7.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung,

Background/aims: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric acid transporters in animals with metabolic syndrome. Read More

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December 2018

Prediction of ESRD in IgA Nephropathy Patients from an Asian Cohort: A Random Forest Model.

Kidney Blood Press Res 2018 Dec 7;43(6):1852-1864. Epub 2018 Dec 7.

Department of Nephrology, the Second Xiangya Hospital, Central South University, Key laboratory of Kidney disease and Blood Purification in Hunan Province, Changsha,

Background/aims: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied.

Methods: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Read More

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December 2018

Proteinuria, Estimated Glomerular Filtration Rate and Urinary Retinol-Binding Protein as Clinical Predictors of Long-Term Allograft Outcomes in Transplant Glomerulopathy.

Kidney Blood Press Res 2018 Dec 7;43(6):1842-1851. Epub 2018 Dec 7.

Background/aims: We aimed to explore the associations between clinical parameters and long-term allograft outcomes in transplant glomerulopathy (TG) in a large retrospective cohort with long follow-up.

Methods: Clinical and laboratory data at biopsy from 180 cases of TG with an estimated glomerular filtration rate (eGFR)> 15ml/min/1.73m2 from January 2004 to December 2016 at our center were retrospectively analyzed. Read More

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December 2018

Effects of the strict control of blood pressure in pediatric renal transplant recipients-ESCORT trial.

Pediatr Transplant 2018 Dec 9:e13329. Epub 2018 Dec 9.

Department of Pediatrics and Transplantation Center, University Hospital Motol, 2nd Medical Faculty Prague, Charles University Prague, Prague, Czech Republic.

Objectives: Strict BP control can retard progression of CKD in children. This prospective 3-year randomized controlled trial is aimed to investigate whether strict BP control can retard progression of chronic allograft dysfunction.

Methods: Twenty-three pediatric patients were randomly selected to the standard BP group (STAND, target 24-hour MAP 50-95th percentile, n = 11) or the intensified BP group (INTENS, target 24-hour MAP <50th percentile, n = 12). Read More

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December 2018

Efficacy and safety of rituximab therapy for membranous nephropathy: a meta-analysis.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8021-8029

Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, China.

Objective: Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults, but the treatment of MN remains controversial. Rituximab, a possible alternative treatment option, represented a new therapeutic hope for the treatment of membranous nephropathy (MN). We performed a meta-analysis to perform the efficacy and safety of rituximab therapy. Read More

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November 2018
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Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement.

Int Urol Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.

Purpose: To assess the role of serum pigment epithelium-derived factor (PEDF) in the occurrence and development of proteinuria and renal dysfunction and determine its relevant signaling pathway.

Methods: We analyzed serum PEDF, creatinine, the urinary albumin-to-creatinine ratio, and renal morphology of normal or streptozotocin (STZ)-induced diabetic mice, before and after treatment with PEDF. In vitro, podocytes were stimulated with PEDF under normal or high-glucose conditions; permeability was measured by the transwell assay with fluorescein isothiocyanate (FITC)-dextran; and F-actin cytoskeleton was analyzed by phalloidin staining. Read More

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December 2018

Glomerular isolated microscopic hematuria: urinary features and long term follow-up of a selected cohort of patients.

J Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Clinical and Research Laboratory on Urinary Sediment, U.O.C. di Nefrologia, Dialisi e Trapianto di Rene, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda, 15, Milan, Italy.

Background: Isolated microscopic hematuria is a condition characterized by the presence in the urine of an "abnormal" number of erythrocytes in the absence of proteinuria. Several studies have been published on this condition, but with heterogeneous inclusion criteria and variable outcomes at follow-up. In this retrospective study, we describe a selected and homogenous cohort of patients who presented with isolated microscopic hematuria of glomerular origin. Read More

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December 2018

Multifactorial Origin of Exertional Rhabdomyolysis, Recurrent Hematuria, and Episodic Pain in a Service Member with Sickle Cell Trait.

Case Rep Genet 2018 7;2018:6898546. Epub 2018 Nov 7.

Consortium for Health and Military Performance, Department of Military and Emergency Medicine, Hébert School of Medicine, Uniformed Services University, 4301 Jones Bridge Rd., Bethesda, MD 20184, USA.

Individuals with Sickle Cell Trait (SCT), generally considered a benign carrier state of hemoglobin S (HbAS), are thought to be at risk for exertional rhabdomyolysis and hematuria, conditions that can also be caused by various other acquired and inherited factors. We report an SCT positive service member with an exertional rhabdomyolysis event, recurrent hematuria with transient proteinuria, and episodic burning pain in the lower extremities. Clinical and genetic studies revealed the multifactorial nature of his complex phenotype. Read More

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November 2018

Calculated Versus Measured Urine Osmolarity: Accuracy of Estimated Urine Density.

Rev Invest Clin 2018 ;70(6):310-318

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City, México.

Background: Urine osmolarity (OsmU) is the gold standard for the evaluation of the kidney's urine concentration capacity; nevertheless, urinary density (UD) is often used as a surrogate for its estimation.

Objective: The objective of this study was to analyze the accuracy of UD in estimating OsmU.

Materials And Methods: A transversal study including patients with simultaneous determination of UD measured with refractometry and OsmU measured by osmometer (OsmUm). Read More

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January 2018

The incessant search for renal biomarkers: is it really justified?

Curr Opin Nephrol Hypertens 2018 Dec 5. Epub 2018 Dec 5.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Purpose Of Review: This review summarizes the most recent and relevant findings in the search for novel biomarkers for the most common renal diseases.

Recent Findings: Unprecedented, fast-paced technical advances in biomedical research have offered an opportunity to identify novel and more specific renal biomarkers in several clinical settings. However, despite the huge efforts made, the molecules identified so far have generally failed to provide relevant information beyond what has already been generated by established biomarkers, such as serum creatinine and proteinuria, whereas the complexity and costs of these technology platforms hamper their widespread implementation. Read More

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December 2018

mTOR inhibitors in pediatric liver transplant recipients.

Clin Res Hepatol Gastroenterol 2018 Dec 6. Epub 2018 Dec 6.

Swiss center for liver disease in children, university hospitals Geneva, Geneva, Switzerland.

Background: During the past decade, mTOR inhibitors (mTORi), everolimus and sirolimus, have been increasingly used after adult liver transplantation (LT). The aim of the present study was to describe the use of mTORi in pediatric LT recipients.

Methods: All pediatric LT recipients who received mTORi before December 2017 from 4 European pediatric LT centers were included and analyzed. Read More

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December 2018

Discovery and qualification of candidate urinary biomarkers of disease activity in lupus nephritis.

J Proteome Res 2018 Dec 10. Epub 2018 Dec 10.

Lupus nephritis (LN) is a severe clinical manifestation of systemic lupus erythematosus (SLE) associated with significant morbidity and mortality. Assessment of severity and activity of renal involvement in SLE requires a kidney biopsy, an invasive procedure with limited prognostic value. Non-invasive biomarkers are needed to inform treatment decisions and to monitor disease activity. Read More

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December 2018

Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway.

Cell Physiol Biochem 2018 6;51(5):2030-2040. Epub 2018 Dec 6.

Department of Obstetrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing,

Background/aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.

Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence staining. Read More

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December 2018
2 Reads

Increased urinary miR-196a level predicts the progression of renal injury in patients with diabetic nephropathy.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Background: Recent data suggest that miR-196a is predominantly expressed in the kidney and plays an inhibitory role in the progress of renal interstitial fibrosis (IF). However, the predictive value of miR-196a in diabetic nephropathy (DN) remains unknown. We validated the role of urinary miR-196a in the progression of renal injury in a cohort of patients with type 2 diabetes mellitus. Read More

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December 2018

Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway.

Inflammation 2018 Dec 5. Epub 2018 Dec 5.

Department of Nephrology, Affiliated Hospital of Southwest Medical University, No. 25, Tai Ping Street, Jiangyang District, 646000, Luzhou, China.

Schisandrin B (SchB) is an active compound extracted from the Chinese herb Schisandra chinensis and shows excellent anti-inflammatory activity. This study was performed to examine the effects of SchB in a rat model of IgA nephropathy (IgAN). IgAN was established in Sprague-Dawley rats by immunization with lipopolysaccharide (LPS), bovine serum albumin, and carbon tetrachloride. Read More

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December 2018

Thrombotic Microangiopathy with Severe Proteinuria Induced by Lenvatinib for Radioactive Iodine-Refractory Papillary Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):735-741. Epub 2018 Nov 12.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. Read More

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November 2018

Virus- and cell type-specific effects in orthohantavirus infection.

Virus Res 2018 Nov 30;260:102-113. Epub 2018 Nov 30.

Department of Nephrology, University of Heidelberg, Heidelberg, Germany. Electronic address:

Orthohantaviruses Hantaan (HTNV) and Puumala (PUUV) virus cause hemorrhagic fever with renal syndrome (HFRS), that is characterized by acute renal failure with often massive proteinuria and by morphological changes of the tubular and glomerular apparatus. Orthohantaviral N protein is found in renal cells and plays a key role in replication. However, the replication in human renal cells is not well characterized. Read More

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November 2018
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Relationships among urinary protein-to-creatinine ratio, urine specific gravity, and bacteriuria in canine urine samples.

J Vet Intern Med 2018 Dec 2. Epub 2018 Dec 2.

Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, Athens, Georgia.

Background: Proteinuria is a marker of chronic kidney disease in dogs and a risk factor for increased morbidity and death. Predictive models using the results of readily available screening tests could foster early recognition.

Objective: To determine whether urine specific gravity (USG) and semiquantitative category of dipstick protein can be used to predict urinary protein-to-creatinine ratio (UP : C) and to examine the effect of urine culture results on UP : C in dogs. Read More

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December 2018
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Potential Blood Pressure Goals in IgA Nephropathy: Prevalence, Awareness, and Treatment Rates in Chronic Kidney Disease Among Patients with Hypertension in China (PATRIOTIC) Study.

Kidney Blood Press Res 2018 Nov 30;43(6):1786-1795. Epub 2018 Nov 30.

Background/aims: IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA nephropathy, our aim was to critically appraise the potential BP goal in IgA nephropathy. Read More

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November 2018

Hematuria and Proteinuria in Children.

Pediatr Rev 2018 Dec;39(12):573-587

Icahn School of Medicine at Mount Sinai, New York, NY.

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December 2018

[Pulmonary hypertension as presentation in multiple myeloma].

Medicina (B Aires) 2018 ;78(6):443-446

Centro de Medicina Respiratoria, Hospital Británico de Buenos Aires, Argentina.

Multiple myeloma is a hematologic disease, which accounts for 15% of hematologic malignancies. The average age of onset is between 65-70 years and is very rare in young patients, as 2% are under 40 years old. We present a case of 36-year-old women with history of 20 pack years (p/y) smoking, who complaints of dyspnea associated with signs of right cardiac overload, anemia, proteinuria, elevated acute phase reactants and spirometry pattern suggestive of moderately-severe restriction and severe drop in diffusing capacity for carbon monoxide (DLCO). Read More

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January 2018

Relationship Between Uric Acid, Proteinuria, and Atherogenic Index of Plasma in Renal Transplant Patients.

Authors:
Z Biyik I Guney

Transplant Proc 2018 May 29. Epub 2018 May 29.

Health Science University, Konya Research and Training Hospital, Nephrology Department, Konya, Turkey.

This study aimed to determine the association of atherogenic index of plasma (AIP) with both hyperuricemia and proteinuria in renal transplant recipients.

Material And Methods: Between the years 2015 and 2017, 61 renal transplant recipients with at least 1 year of follow-up were included in this retrospective cohort study. Uric acid levels of ≥7 mg/dL in men and ≥6 mg/dL in women were accepted as hyperuricemia. Read More

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Severe Sinus Bradycardia in Puumala virus infection.

Int J Infect Dis 2018 Nov 29. Epub 2018 Nov 29.

Service de Médecine Interne, CHRU de Besançon, Besançon, France. Electronic address:

Puumala orthohantavirus (PUUV) is the most prevalent of the four species of zoonotic hantaviruses found in Europe, causing nephropathia epidemica, a mild form of hemorrhagic fever with acute kidney injury that presents with elevated serum creatinine level, proteinuria and hematuria. The febrile phase of the infection begins by flu-like syndrome, visual disturbance. Laboratory results can show thrombocytopenia. Read More

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November 2018
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[Study on Immunophenotypes and Gene of Acute Lymphoblastic Leukemia--Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1831-1835

Hematology Oncology Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing Key Laboratory of Hematological Diseases and Tumor Molecular Classification, National Key Discipline of Pediatrics, Beijing 100045, China.

Transplantation-associated thrombotic microangiopathy (TA-TMA) is one of the fatal complications of hematopoietic stem cell transplantation(HSCT). The pathogenesis of TA-TMA has not been fully elucidated. The latest researches show that the abnormal activation of the complement system may lead to widespread endothelial injury which may play an important role in the pathogenesis of this disease. Read More

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December 2018

Hypotonia and delayed motor development as an early presentation of Lowe syndrome: case report and literature review.

Acta Clin Belg 2018 Dec 3:1-5. Epub 2018 Dec 3.

a Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology , Ghent University Hospital , Ghent , Belgium.

We describe a boy who presented with neonatal hypotonia, followed by delayed motor development and growth impairment. Further evaluation revealed rickets caused by proximal renal tubular dysfunction. At age 3, the boy exhibited dysmorphic features and bilateral cataract. Read More

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December 2018

Does blood contamination of urine compromise interpretation of the urine protein to creatinine ratio in dogs?

N Z Vet J 2018 Dec 5:1-14. Epub 2018 Dec 5.

a School of Veterinary Science, Massey University , Private Bag 11-222, Palmerston North , 4442 , New Zealand.

Aims: To determine the effect of contamination of urine with 0-5% blood, varying in haematocrit and protein concentrations, on the urine protein to creatinine ratio (UPC) in dogs, and to determine whether the colour of urine can be used to aid interpretation of UPC results.

Methods: Urine samples were collected by free catch from 18 dogs, all of which had UPC <0.2. Read More

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December 2018

CHANGES OF PROTEINURIA AND ACID-REGULATING KIDNEY FUNCTION IN MATURE RATS WITH SLOW AND RAPID ACETYLATION TYPE UNDER CONDITIONS OF SUBACUTE CADMIUM-NITRATE INTOXICATION.

Georgian Med News 2018 Oct(283):133-137

Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine.

The experiments conducted on non-linear mature laboratory albino rats determined that under conditions of subacute cadmium-nitrate intoxication the indices of proteinuria and acid-regulating renal function depend on acetylation phenotype. Unlike rapid acetylators considerable increase of protein concentration in urine (192,8%, р<0,05) and standardized by glomerular filtration protein excretion (141,7%, р<0,05) are indicative of higher susceptibility of rats with slow acetylation type to nephrotoxic action of cadmium chloride and sodium nitrate. Lack of protein loss with urine and adaptive-compensative character of acid-regulating renal function changes directed to elimination of hydrogen ions excess from the body give evidence concerning less intensive damage of the nephron tubular portion in rats with rapid acetylation type, and at the same time do not exclude development of nephropathy. Read More

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October 2018
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Upregulated microRNAs in membranous glomerulonephropathy are associated with significant downregulation of IL6 and MYC mRNAs.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Section of Biology and Genetics Giovanni Sichel, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

Membranous glomerulonephropathy (MGN) is a glomerulopathy characterized by subepithelial deposits of immune complexes on the extracapillary side of the glomerular basement membrane. Insertion of C5b-9 (complement membrane-attack complex) into the membrane leads to functional impairment of the glomerular capillary wall. Knowledge of the molecular pathogenesis of MGN is actually scanty. Read More

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December 2018

Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity.

Open Forum Infect Dis 2018 Nov 24;5(11):ofy275. Epub 2018 Oct 24.

Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Although the use of tenofovir alafenamide (TAF), a new prodrug of tenofovir, was safe and efficacious in clinical trials, real-world data from multimorbid individuals are scarce. Among 10 persons living with HIV with previous tenofovir disoproxil fumarate-induced nephrotoxicity, renal function remained stable, and proteinuria decreased in several patients after the switch to TAF. Read More

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November 2018

Evaluation of antiproteinuric and hepato-renal protective activities of propolis in paracetamol toxicity in rats.

Nutr Res Pract 2018 Dec 23;12(6):535-540. Epub 2018 Nov 23.

Laboratory Physiology-Pharmacology & Environmental Health, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez 30000, Morocco.

Background/objectives: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of propolis against paracetamol-induced liver damage and impairment of kidney function, as well as hematological changes in rats.

Materials And Methods: Six groups of rats were used; the first group was served as a control; the second and third groups were treated by propolis extract at a dose of 50 and 100 mg/kg. Read More

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December 2018

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening.

Nat Commun 2018 12 4;9(1):5167. Epub 2018 Dec 4.

Murdoch Children's Research Institute, Flemington Rd, Melbourne, 3052, VIC, Australia.

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have employed primary or immortalised podocyte cell lines cultured in 2D. Here we compare 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids with conditionally immortalised human podocyte cell lines, revealing improved podocyte-specific gene expression, maintenance in vitro of polarised protein localisation and an improved glomerular basement membrane matrisome compared to 2D cultures. Read More

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December 2018

Evidence for a role of Angiotensin Converting Enzyme 2 in proteinuria of idiopathic nephrotic syndrome.

Biosci Rep 2018 Dec 4. Epub 2018 Dec 4.

UFMG, Belo Horizonte, Brazil

Introduction: Renin Angiotensin System (RAS) plays a role in idiopathic nephrotic syndrome (INS). Most studies investigated only the classical RAS axis. Therefore, the aims of this study were to evaluate urinary levels of RAS molecules related to classical and to counter-regulatory axes in pediatric patients with INS, to compare the measurements with levels in healthy controls and to search for associations with inflammatory molecules, proteinuria and disease treatment. Read More

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December 2018

Competing-Risk Analysis of Death and End Stage Kidney Disease by Hyperkalaemia Status in Non-Dialysis Chronic Kidney Disease Patients Receiving Stable Nephrology Care.

J Clin Med 2018 Dec 1;7(12). Epub 2018 Dec 1.

Division of Nephrology, Department of Advanced Medical and Surgical Sciences, Nephrology Unit-University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Hyperkalaemia burden in non-dialysis chronic kidney disease (CKD) under nephrology care is undefined. We prospectively followed 2443 patients with two visits (referral and control with 12-month interval) in 46 nephrology clinics. Patients were stratified in four categories of hyperkalaemia (serum potassium, sK ≥ 5. Read More

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December 2018

Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation.

Acta Physiol (Oxf) 2018 Nov 30:e13227. Epub 2018 Nov 30.

Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Aim: Chronic high salt intake exaggerates renal injury and inflammation, especially with the loss of functional ET receptors. Tauroursodeoxycholic acid (TUDCA) is a chemical chaperone and bile salt that is approved for the treatment of hepatic diseases. Our aim was to determine whether TUDCA is reno-protective in a model of ET receptor deficiency with chronic high salt-induced renal injury and inflammation. Read More

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November 2018
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Accelerated podocyte detachment early after kidney transplantation is related to long-term allograft loss of function.

Nephrol Dial Transplant 2018 Nov 29. Epub 2018 Nov 29.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Background: Kidney allograft half-life has not improved despite excellent short-term survival. Recent long-term surveillance biopsy studies identify accumulating glomerulosclerosis (GS) to be associated with late allograft loss. While podocyte depletion is well known to drive proteinuria and GS in animal models and human glomerular diseases, its role in renal allograft loss of function is generally not recognized. Read More

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November 2018
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Long-term antitumor effect of lenvatinib on unresectable hepatocellular carcinoma with portal vein invasion: A case report.

Hepatol Res 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan.

Background: Lenvatinib is a novel multi-kinase inhibitor, which has recently demonstrated antitumor activity against hepatocellular carcinoma (HCC) in a phase III trial. We report the case of a woman in whom lenvatinib showed long-term antitumor activity, and in whom CT scans demonstrated a series of suggestive radiological changes on the intra-tumor vascularity.

Case Presentation: A 68-year-old woman with hepatitis C virus-related liver disease presented with multiple HCCs. Read More

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November 2018
3 Reads

Still Asking "Which Rate Is Right?" Years Later.

Clin J Am Soc Nephrol 2018 Dec 29;13(12):1783-1784. Epub 2018 Nov 29.

Division of Nephrology, Department of Medicine, University of California, San Diego, California; and

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December 2018
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Preoperative proteinuria and clinical outcomes in type B aortic dissection after thoracic endovascular aortic repair.

Clin Chem Lab Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Vascular Surgery, Shenzhen Second Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, P.R. China.

Background Proteinuria is a marker of poor outcomes in several diseases; however, few studies have been conducted to explore the prognostic value of proteinuria, assessed by urine dipstick test, for clinical outcomes in patients with type B acute aortic dissection (TBAD) undergoing thoracic endovascular aortic repair (TEVAR). Methods Consecutive patients with TBAD undergoing TEVAR were enrolled from January 2010 to July 2015. Proteinuria was defined as trace or higher, according to the results of urine dipstick testing. Read More

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November 2018

Combined immunosuppressive treatment (CIST) in lupus nephritis: a multicenter, randomized controlled study.

Clin Rheumatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Rheumatology and Immunology, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.

Objectives: The standard strategy for treating lupus nephritis comprises glucocorticoids together with either intravenous cyclophosphamide or oral mycophenolate mofetil, but the low remission rate is still a challenge in practice. This study was aimed to seek higher remission rate of lupus nephritis using a combined strategy.

Method: A 24-week trial was conducted in 17 rheumatology or nephrology centers in China. Read More

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November 2018
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Response of Proliferative Lupus Nephritis with Pulse Cyclophosphamide Therapy during Induction Period: A Single Centre Study in Bangladesh.

Mymensingh Med J 2018 Oct;27(4):693-701

Dr Mohammad Bellal Hossain, Medical Officer, Department of Nephrology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh.

This prospective study was conducted to assess the response of proliferative lupus nephritis with pulse cyclophosphamide therapy during induction period in the department of Nephrology of Dhaka Medical College, Dhaka, Bangladesh from December 2012 to November 2013. A total of 35 clinically diagnosed SLE patients of class III/IV lupus nephritis were included. But 3 patients were dropped out during follow-up, therefore finally 32 patients (class III = 4, class IV = 28) were studied. Read More

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October 2018

The Number of Comorbidities Predicts Renal Outcomes in Patients with Stage 3⁻5 Chronic Kidney Disease.

J Clin Med 2018 Nov 28;7(12). Epub 2018 Nov 28.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Background: Chronic kidney disease (CKD) is a global health threat affecting approximately 10% of the adult population worldwide. Multimorbidity is common in CKD, but its impacts on disease outcomes are seldom investigated.

Methods: This prospective cohort analysis followed patients, who were part of a multidisciplinary CKD care program, for 10 years. Read More

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November 2018

[Renal involvement during monoclonal gammopathies at the teaching hospital of Yopougon in Abidjan, from 2000 to 2016].

Mali Med 2018 ;33(1):6-9

Service de Néphrologie, CHU de Yopougon. Adresse : 21 BP 632 Abidjan 21.

Background: Renal involvement is common during monoclonal gammopathies and their occurrence impacts the survival of the patients. Our objective was to describe the renal features during monoclonal gammopathies from 2004 to 2016 at the University Hospital of Yopougon in Abidjan.

Methods: Renal failure was defined as blood creatinine level > 20 mg/L and/or proteinuria > 500 mg/24 hours. Read More

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January 2018
2 Reads

Editorial: Molecular Mechanisms of Proteinuria.

Authors:
Sandra Merscher

Front Med (Lausanne) 2018 12;5:300. Epub 2018 Nov 12.

Katz Family Division of Nephrology and Hypertension, Department of Medicine, Peggy and Harold Katz Family Drug Discovery Center, University of Miami Miller School of Medicine, Miami, FL, United States.

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November 2018

Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats.

Front Physiol 2018 13;9:1599. Epub 2018 Nov 13.

Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain.

The aim of this study was to investigate if urinary glutamyl aminopeptidase (GluAp), alanyl aminopeptidase (AlaAp), Klotho and hydroxyproline can be considered as potential biomarkers of renal injury and fibrosis in an experimental model of obesity. Male Zucker lean (ZL) and obese (ZO) rats were studied from 2 to 8 months old. Kidneys from ZO rats at the end of the study (8 months old) developed mild focal and segmental glomerulosclerosis as well as moderate tubulointerstitial injury. Read More

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November 2018

Risk Factors for Recurrent Acute Kidney Injury in a Large Population-Based Cohort.

Am J Kidney Dis 2018 Oct 10. Epub 2018 Oct 10.

Division of Nephrology, Department of Medicine, University of California, San Francisco, CA; Division of Research, Kaiser Permanente Northern California, Oakland, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA; Department of Medicine, Stanford University School of Medicine, Stanford, CA; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA.

Rationale & Objective: Acute kidney injury (AKI) has numerous sequelae. Repeated episodes of AKI may be an important determinant of adverse outcomes, including chronic kidney disease and death. In a population-based cohort study, we sought to determine the incidence of and predictors for recurrent AKI. Read More

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October 2018

Clinical features and long-term outcomes of diabetic kidney disease - A prospective cohort study from China.

J Diabetes Complications 2018 Oct 12. Epub 2018 Oct 12.

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China; Peking University, Center for Data Science in Health and Medicine, Beijing, China. Electronic address:

Background: Information regarding the clinical phenotypes of diabetic kidney disease (DKD) might guide better practice for clinicians. We aim to compare the clinical features and long-term outcomes of proteinuric and non-proteinuric phenotypes of DKD, based on a prospective cohort of Chinese population.

Methods: Altogether 8811 Chinese participants with diabetes were included. Read More

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October 2018

[Preeclampsia: New Classifications].

Praxis (Bern 1994) 2018 Nov;107(24):1333-1337

1 Klinik für Geburtshilfe & Pränataldiagnostik, Kantonsspital Baden AG.

Preeclampsia: New Classifications Abstract. Preeclampsia is a multisystem disease leading to systemic impairment of the maternal endothelial function. A dysbalance of pro- and antiangiogenic factors appears to be significantly involved. Read More

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November 2018

Anti-angiogenic therapy for high-grade glioma.

Cochrane Database Syst Rev 2018 11 22;11:CD008218. Epub 2018 Nov 22.

Medical Oncology, Alfred Hospital, Commercial Road, Melbourne, Victoria, Australia, 3004.

Background: This is an updated version of the original Cochrane Review published in September 2014. The most common primary brain tumours in adults are gliomas. Gliomas span a spectrum from low to high grade and are graded pathologically on a scale of one to four according to the World Health Organization (WHO) classification. Read More

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November 2018
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Treatment of hypertension induced albuminuria.

Curr Pharm Des 2018 Nov 26. Epub 2018 Nov 26.

Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Croatia School of Medicine, University of Zagreb. Croatia.

Regardless of having similar antihypertensive effect, different antihypertensive drug classes have different effect on albuminuria.Patients with albuminuria will usually need more than one drug to achieve blood pressure control, particularly if the aim is also to reduce albuminuria.Albuminuria is independently associated with cardiovascular and renal risk regardless of diabetes status. Read More

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November 2018
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