62,534 results match your criteria Proteinuria


Proximal renal tubular function in HIV-infected children on tenofovir disoproxil fumarate for treatment of HIV infection at two tertiary hospitals in Harare, Zimbabwe.

PLoS One 2020 7;15(7):e0235759. Epub 2020 Jul 7.

Department of Paediatrics, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.

Background: Renal abnormalities in HIV infected children may be due to the HIV infection or treatment among other factors. Tenofovir disoproxil fumarate (TDF) is associated with proximal renal tubular dysfunction, proteinuria and decrease in glomerular function. Studies in developed countries have shown variable prevalence of proximal renal tubular dysfunction in children on TDF. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235759PLOS

The Effect of Bariatric Surgery on Patients with Chronic Kidney Disease.

Obes Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Minimal Access, Metabolic and Bariatric Surgery, Max Super Speciality Hospital, Press Enclave Road, Saket, New Delhi, 110017, India.

The effect of bariatric surgery on renal functions of patients with chronic kidney disease (CKD) is not well characterized. This prospective study included 13 adult patients having chronic kidney disease who underwent bariatric surgery. The primary objective was to examine the change in glomerular filtration rate (GFR) at 6 months post-bariatric surgery. Read More

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http://dx.doi.org/10.1007/s11695-020-04812-wDOI Listing

The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases.

Biomolecules 2020 Jun 25;10(6). Epub 2020 Jun 25.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation. MMP-7 is barely expressed in normal adult kidney but upregulated in acute kidney injury (AKI) and chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.3390/biom10060960DOI Listing

Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Centro de Fisiología Celular e Integrativa, Facultad de Medicina Clínica Alemana,Universidad del Desarrollo, Santiago 7690000, Chile.

Preeclampsia is a pregnancy complication that appears after 20 weeks of gestation and is characterized by hypertension and proteinuria, affecting both mother and offspring. The cellular and molecular mechanisms that cause the development of preeclampsia are poorly understood. An important feature of preeclampsia is an increase in oxygen and nitrogen derived free radicals (reactive oxygen species/reactive nitrogen species (ROS/RNS), which seem to be central players setting the development and progression of preeclampsia. Read More

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http://dx.doi.org/10.3390/ijms21134698DOI Listing

Remission of Proteinuria May Protect against Progression to Chronic Kidney Disease in Pediatric-Onset IgA Nephropathy.

J Clin Med 2020 Jun 30;9(7). Epub 2020 Jun 30.

Seoul National University College of Medicine and Seoul National University Children's Hospital, Seoul 03080, Korea.

Immunoglobulin A nephropathy (IgAN) is one of the most common primary glomerulopathies diagnosed in children and adolescents. This study aimed to evaluate the clinical features in and outcomes of pediatric IgAN over the last 30 years. Patients who were diagnosed before age of 18 at 20 centers in Korea were evaluated retrospectively. Read More

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http://dx.doi.org/10.3390/jcm9072058DOI Listing

A single-center analysis of primary nephrotic syndrome with acute pancreatitis in children.

Medicine (Baltimore) 2020 Jul;99(27):e21056

Department of Nephrology and Rheumatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Primary nephrotic syndrome (PNS) is one of the most common primary glomerular diseases in children. Patients complicated nephrotic syndrome with pancreatic lesions are rarely reported, and the clinical manifestations in children are atypical. This study has observed the incidence, clinical types, and prognosis of acute pancreatitis (AP) in children with primary nephrotic syndrome, and analyzed its related factors, early diagnosis, and treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000021056DOI Listing

Long-term Renal Outcome of Biopsy-proven Acute Tubular Necrosis and Acute Interstitial Nephritis.

J Korean Med Sci 2020 Jul 6;35(26):e206. Epub 2020 Jul 6.

Division of Nephrology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Background: Although emerging evidence suggest acute kidney injury (AKI) progress to chronic kidney disease (CKD), long-term renal outcome of AKI still remains unclear. Acute tubular necrosis (ATN) is the most common cause of AKI due to ischemia, toxin or sepsis. Acute interstitial nephritis (AIN), caused by drugs or autoimmune diseases is also increasingly recognized as an important cause of AKI. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e206DOI Listing

The Prevalence of Nondiabetic Renal Diseases in Patients with Diabetes Mellitus in the University Hospital of Ribeirão Preto, São Paulo.

J Diabetes Res 2020 13;2020:2129459. Epub 2020 Jun 13.

Nephrology Division, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.

Objective: To evaluate the prevalence of nondiabetic renal diseases (NDRDs) in renal biopsies of patients with diabetes mellitus (DM) in the University Hospital of Ribeirão Preto, São Paulo. . We conducted a retrospective study including kidney biopsies performed in diabetic patients between 1987 and 2013. Read More

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http://dx.doi.org/10.1155/2020/2129459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312549PMC

Let-7c-5p Is Involved in Chronic Kidney Disease by Targeting TGF- Signaling.

Biomed Res Int 2020 12;2020:6960941. Epub 2020 Jun 12.

Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.

The purpose of the present study was to investigate the expressions of hsa-let-7c-5p and TGF- signaling-related molecules and their correlations with clinical characteristics in chronic kidney disease (CKD). Twenty-three biopsy specimens of CKD patients and 20 negative control tissues were selected. Quantitative real-time PCR (qPCR) was used for the detection of hsa-let-7c-5p, transforming growth factor (TGF-) and TGF- receptor type 1 (TGF-R1) expression levels. Read More

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http://dx.doi.org/10.1155/2020/6960941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306863PMC

Affinity-Enhanced Multimeric VEGF (Vascular Endothelial Growth Factor) and PlGF (Placental Growth Factor) Variants for Specific Adsorption of sFlt-1 to Restore Angiogenic Balance in Preeclampsia.

Hypertension 2020 Jul 6:HYPERTENSIONAHA12014974. Epub 2020 Jul 6.

From the Department II of Internal Medicine, University of Cologne, Faculty of Medicine, University Hospital Cologne, Germany (M. Matin, B.S., P.T.B., T.B., H.H.).

Preeclampsia is a potentially life-threatening multisystem disease affecting 4% to 8% of pregnant women after the 20th week of gestation. An excess of placental expressed antiangiogenic soluble VEGF (vascular endothelial growth factor)-receptor 1 (soluble FMS-like tyrosine kinase 1) scavenges VEGF and PlGF (placental growth factor), causing generalized endothelial dysfunction. Interventions to restore the angiogenic balance in preeclamptic pregnancies are intensively studied and improve maternal and neonatal outcomes. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14974DOI Listing

The relationship between Helicobacter pylori and chronic kidney disease: update 2020.

Minerva Gastroenterol Dietol 2020 Jul 3. Epub 2020 Jul 3.

Renal Transplantation Center "A. Vercellone", Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.

A number of studies has confirmed that the epidemiology of Helicobacter pylori (H. pylori) is changing worldwide, with a decrease especially in developed Countries. Nevertheless, since this Gram-negative bacterium infects almost 50% of the world's population, it remains a global problem. Read More

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http://dx.doi.org/10.23736/S1121-421X.20.02729-4DOI Listing

A case of acute renal failure with multiple origins of the renal injury.

CEN Case Rep 2020 Jul 4. Epub 2020 Jul 4.

Nephrology and Dialysis Unit, Belcolle Hospital, Via Sammartinese, Snc, 01100, Viterbo, Italy.

Acute kidney injury (AKI) is an abrupt and usually reversible decline in the glomerular filtration rate (GFR). Patients with AKI must be evaluated promptly to determine cause. Different disorders can BE associated with AKI, and biopsy is the most accurate instrument for diagnosis of different types of diseases. Read More

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http://dx.doi.org/10.1007/s13730-020-00505-6DOI Listing

The prevalence of chronic kidney disease in Iceland according to KDIGO criteria and age-adapted estimated glomerular filtration rate thresholds.

Kidney Int 2020 Jul 2. Epub 2020 Jul 2.

Internal Medicine Services, Landspitali-The National University Hospital of Iceland; Division of Nephrology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. Electronic address:

Most epidemiological studies on chronic kidney disease (CKD) are based solely on estimated glomerular filtration rates (eGFR). Few studies have included proteinuria, while the chronicity criterion is usually omitted. To explore this, we examined the prevalence of CKD stages 1-5 in Iceland based on multiple markers of kidney damage. Read More

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http://dx.doi.org/10.1016/j.kint.2020.06.017DOI Listing

Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis.

Kidney Int 2020 Apr 28. Epub 2020 Apr 28.

Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, Japan; Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki, Japan. Electronic address:

Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant nephrotic syndrome. Spontaneous remission of FSGS is rare and steroid-resistant FSGS frequently progresses to renal failure. Many inheritable forms of FSGS have been described, caused by mutations in proteins that are important for podocyte function. Read More

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http://dx.doi.org/10.1016/j.kint.2020.02.038DOI Listing

Rapid progression to end-stage renal disease in a child with IgA-dominant infection-related glomerulonephritis associated with parvovirus B19.

CEN Case Rep 2020 Jul 3. Epub 2020 Jul 3.

Department of Pediatric Nephrology, School of Medicine, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Parvovirus B19 (PVB19) has been known to cause acute glomerulonephritis and nephrotic syndrome with various renal histologic patterns, such as endocapillary glomerulonephritis and collapsing glomerulopathy. Remission is achieved spontaneously or by treatment with steroid and/or immunosuppressants in most patients, except those with sickle cell anemia or two APOL1 risk alleles. In this study, we report the case of a previously healthy 5-year-old boy with infection-related glomerulonephritis (IRGN) associated with PVB19 that progressed to end-stage renal disease (ESRD). Read More

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http://dx.doi.org/10.1007/s13730-020-00501-wDOI Listing

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas.

Anticancer Res 2020 Jul;40(7):4017-4022

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Naples, Italy

Background/aim: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT). It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step. Read More

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http://dx.doi.org/10.21873/anticanres.14396DOI Listing

Placental Extracellular Vesicles and Preeclampsia.

Am J Reprod Immunol 2020 Jul 3:e13297. Epub 2020 Jul 3.

Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, USA.

Preeclampsia is a hypertensive disease of pregnancy characterized by new-onset hypertension, with either proteinuria and/or organ dysfunction. Preeclampsia is a leading cause of maternal morbidity and mortality; however, the underlying cellular and molecular mechanisms are not well understood. There is consensus that the underlying mechanism(s) resulting in preeclampsia is centered around abnormal placentation, inadequate spiral-artery remodeling, and deficiency in trophoblast invasion, resulting in impaired maternal blood flow to the placenta and a release of signals and/or inflammatory mediators into maternal circulation triggering the systemic manifestations of preeclampsia. Read More

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http://dx.doi.org/10.1111/aji.13297DOI Listing

LncRNA ANRIL Silencing Alleviates High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis via Upregulation of MME in Podocytes.

Inflammation 2020 Jul 3. Epub 2020 Jul 3.

Department of Nephrology, Jiangsu Province Geriatric Hospital, Geriatric Hospital of Nanjing Medical University, No. 65 Jiangsu Road, Nanjing City, 210009, Jiangsu Province, People's Republic of China.

Diabetic nephropathy (DN), characterized by glomerular injury, is a common complication of both type 1 and type 2 diabetes, accompanied by massive proteinuria. Podocytes are reported to play pivotal roles in maintaining the glomerular filtration barrier. In addition, the expression of long non-coding RNAs (lncRNAs) ANRIL was upregulated in type 2 diabetes patients. Read More

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http://dx.doi.org/10.1007/s10753-020-01282-1DOI Listing

Treatment of fibrillary glomerulonephritis with rituximab: a 12-month pilot study.

Nephrol Dial Transplant 2020 Jul 2. Epub 2020 Jul 2.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.

Background: Fibrillary glomerulonephritis (FGN) is a rare type of glomerulonephritis with poor prognosis, with no known effective therapies available for treatment. The objective of the study was to evaluate the efficacy and safety of rituximab in treatment of patients with FGN and to investigate the effect of rituximab on DNAJB9 levels.

Methods: This was a pilot prospective clinical trial in which patients with idiopathic FGN were treated with two courses of rituximab (1 g each) 2 weeks apart at the beginning and then again at 6 months. Read More

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http://dx.doi.org/10.1093/ndt/gfaa065DOI Listing

Structural features and oligomeric nature of human podocin domain.

Biochem Biophys Rep 2020 Sep 25;23:100774. Epub 2020 Jun 25.

Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.

Podocytes are crucial cells of the glomerular filtration unit and plays a vital role at the interface of the blood-urine barrier. Podocyte slit-diaphragm is a modified tight junction that facilitates size and charge-dependent permselectivity. Several proteins including podocin, nephrin, CD2AP, and TRPC6 form a macromolecular assembly and constitute the slit-diaphragm. Read More

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http://dx.doi.org/10.1016/j.bbrep.2020.100774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322680PMC
September 2020

Angiotensin II receptor 1 antibodies associate with post-transplant focal segmental glomerulosclerosis and proteinuria.

BMC Nephrol 2020 Jul 2;21(1):253. Epub 2020 Jul 2.

Department of Medicine, Division of Nephrology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Carnegie 344B, Baltimore, MD, 21287, USA.

Background: Angiotensin II type 1 receptors (AT1Rs) are expressed on podocytes, endothelial and other cells, and play an essential role in the maintenance of podocyte function and vascular homeostasis. The presence of AT1R antibodies (AT1R-Abs) leads to activation of these receptors resulting in podocyte injury and endothelial cell dysfunction. We assessed the correlation between AT1R-Abs and the risk of post-transplant FSGS. Read More

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http://dx.doi.org/10.1186/s12882-020-01910-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331243PMC

An Alport syndrome boy with Van Wyk-Grumbach syndrome induced by prolonged untreated congenital hypothyroidism.

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):132-136. Epub 2020 Jun 30.

Division of Pediatric Endocrinology, Kyungpook National University Children's Hospital, Daegu, Korea.

Alport syndrome (AS) is a rare genetic disorder that causes progressive nephritis and is more common among males. Studies have reported an association between thyroid antibodies and hypothyroidism in patients with AS, but the relevance of this relationship is under debate. Prolonged untreated hypothyroidism induces short stature, abnormal pubertal development, and various other symptoms. Read More

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http://dx.doi.org/10.6065/apem.1938074.037DOI Listing

Prevalence and risk factors associated with systemic hypertension in dogs with spontaneous hyperadrenocorticism.

J Vet Intern Med 2020 Jul 2. Epub 2020 Jul 2.

Department of Animal Medicine and Surgery, Veterinary Faculty, Complutense University of Madrid, Madrid, Spain.

Background: Systemic hypertension (SH) is common in dogs with hyperadrenocorticism (HAC) however there are not many studies assessing its prevalence and risk factors.

Objectives: To determine the prevalence and severity of SH in dogs with HAC and its association with clinical and laboratory findings to identify potential risk factors.

Animals: Sixty-six client owned dogs with spontaneous HAC. Read More

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http://dx.doi.org/10.1111/jvim.15841DOI Listing

Hypertensive nephrosclerosis: wider kidney biopsy indications may be needed to improve diagnostics.

J Intern Med 2020 Jul 2. Epub 2020 Jul 2.

Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.

Background: Hypertensive nephrosclerosis is the presumed underlying cause in many end stage kidney disease (ESKD) patients, but the diagnosis is disputed and based on clinical criteria with low diagnostic accuracy.

Objective: To evaluate and improve the diagnostic process for nephrosclerosis patients.

Methods: We included adults from the population-based HUNT study (n=50,552), Norwegian CKD patients referred for kidney biopsy 1988-2012 (n=7,261), and unselected nephrology clinic patients (n=193) used for matching. Read More

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http://dx.doi.org/10.1111/joim.13146DOI Listing

Associations between visceral obesity and renal impairment in health checkup participants: a retrospective cohort study.

Clin Exp Nephrol 2020 Jul 1. Epub 2020 Jul 1.

Takeda Hospital Medical Examination Center, Kyoto, 6008216, Japan.

Background: Obesity is a risk factor for chronic kidney disease. Although body mass index (BMI) or waist circumference is indicators of obesity, actual measurements of visceral fat area (VFA) more accurately reflect the amount of visceral fat. We aimed to determine the most sensitive obesity indicator for predicting renal impairment among VFA, BMI, waist circumference, waist-to-height ratio, and visceral-to-subcutaneous fat ratio (VSR). Read More

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http://dx.doi.org/10.1007/s10157-020-01921-9DOI Listing

Obesity is associated with severe clinical course in children with Henoch-Schonlein purpura.

Pediatr Nephrol 2020 Jun 29. Epub 2020 Jun 29.

Faculty of Medicine, Department of Pediatric Rheumatology, Dokuz Eylul University, Izmir, Turkey.

Background: We aimed to evaluate the role of obesity on the clinical course and response to treatment in patients with Henoch-Schonlein purpura (HSP).

Methods: Data charts of children with HSP followed in a tertiary hospital between 2000 and 2018 were reviewed retrospectively. Persistent purpura was defined as skin involvement persisting for ≥ 30 days. Read More

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http://dx.doi.org/10.1007/s00467-020-04672-7DOI Listing

Recurrent angioedema, Guillain-Barré, and myelitis in a girl with systemic lupus erythematosus and CD59 deficiency syndrome.

Auto Immun Highlights 2020 Dec 29;11(1). Epub 2020 Jun 29.

Department of Pediatric Neurology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: CD59 deficiency is a congenital mutation disorder in complement pathway which can present with various manifestations.

Case Presentation: Herein, we presented an adolescent 16-years-old girl with recurrent attacks of Guillain-Barre in early childhood and then recurrent attacks of angioedema, paresthesia, and myelitis. Finally, she presented with quadriplegia, malar rash, proteinuria, lymphopenia, and high titer of antinuclear antibody. Read More

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http://dx.doi.org/10.1186/s13317-020-00132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322911PMC
December 2020

Hydralazine-Induced Isolated Lupus Nephritis.

Ochsner J 2020 ;20(2):187-192

Clinic Operations, Ochsner Clinic Foundation, Baton Rouge, LA.

Hydralazine has been known to cause multiple side effects, both localized and systemic. The literature includes case reports of systemic vasculitis caused by hydralazine. A 79-year-old male with stage 3 chronic kidney disease attributable to hypertension and type 2 diabetes was started on hydralazine to control his hypertension. Read More

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http://dx.doi.org/10.31486/toj.18.0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310176PMC
January 2020

Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy.

J Am Soc Nephrol 2020 Jul 1. Epub 2020 Jul 1.

Department of Nephrology, Juntendo University, Tokyo, Japan

Background: IgA nephropathy (IgAN) begins with aberrant IgA deposition in glomeruli, progresses to IgM/IgG/complement codeposition, and results in chronic inflammation and glomerular damage. However, the mechanism that drives such phlogogenic cascade has been unclear. Recently, apoptosis inhibitor of macrophage (AIM) protein was shown to modulate macrophages' function in various pathologic conditions, thereby profoundly affecting the progression of renal disorders, including AKI. Read More

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http://dx.doi.org/10.1681/ASN.2019100987DOI Listing

Neonatal and Maternal Outcomes among Women with Glomerulonephritis.

Am J Nephrol 2020 Jul 1:1-8. Epub 2020 Jul 1.

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.

Background: The outcomes of pregnancy in women with renal diseases remain controversial. The purpose of the study was to report fetal and maternal outcomes among women with glomerular disease in comparison with healthy pregnant women and a review of the current literature on this issue.

Methods: Retrospective analysis included 72 pregnancies in 62 women with biopsy-proven glomerulonephritis (GN) (in 65. Read More

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http://dx.doi.org/10.1159/000508600DOI Listing

Comparison of the resistive indices obtained in the uterine artery and the ophthalmic artery in preeclamptic and normotensive patients in Doppler US.

J Ultrason 2020 15;20(81):e95-e99. Epub 2020 Jun 15.

University Institute of Radiological Sciences and Medical Imaging Technologies (UIRSMIT), Faculty of Allied Health Sciences (FAHS), University of Lahore , Lahaur , Pakistan.

Preeclampsia is a medical condition characterized by hypertension and proteinuria during pregnancy, with the symptoms generally manifesting in the 3 trimester. Hypertension brings hemodynamic changes; it is therefore expected that arterial blood flow velocity waveforms will be different in the uterine and ophthalmic arteries in preeclampsia. Vascular changes do occur in preeclampsia, which in turn induces hemodynamic changes. Read More

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http://dx.doi.org/10.15557/JoU.2020.0015DOI Listing

Taurine metabolism aggravates the progression of lupus by promoting the function of plasmacytoid dendritic cells.

Arthritis Rheumatol 2020 Jul 1. Epub 2020 Jul 1.

Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, 200001, China.

Objective: Type I interferons (IFN-I) are critical for the development of systemic lupus erythematosus (SLE). Metabolic abnormalities cause dysregulation of multiple immune cells, but the metabolic regulation of IFN-I production is far from clarified in SLE. This study was conducted to define amino acid metabolism features in SLE, and explore the function of disease-relevant metabolite on the control of plasmacytoid dendritic cells (pDCs) mediated IFN-I production and the progression of SLE. Read More

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http://dx.doi.org/10.1002/art.41419DOI Listing

Inhibition of Bruton's tyrosine kinase regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation.

Br J Pharmacol 2020 Jul 1. Epub 2020 Jul 1.

William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.

Background And Purpose: Currently there are limited medicines available for the treatment of metabolic inflammation in diseases such as obesity and type 2 diabetes (T2D). Although initially associated with B-ells, Bruton's tyrosine kinase (BTK) is present in a wide variety of cells including monocytes and macrophages, and has been implicated in the regulation of the NF-κB and NLRP3 inflammasome activity.

Experimental Approach: Using in vivo models of chronic inflammation [high-fat-diet (HFD) feeding] and in vitro assays in primary murine and human macrophages we investigated if ibrutinib, an FDA approved medicine that targets BTK, may represent a novel anti-inflammatory drug for the use in treating metabolic inflammation. Read More

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http://dx.doi.org/10.1111/bph.15182DOI Listing

Diagnosis and Screening of Patients with Fabry Disease.

Ther Clin Risk Manag 2020 22;16:551-558. Epub 2020 Jun 22.

Department of Medicine I, Klinikum Vest, Knappschaftskrankenhaus Recklinghausen, Academic Teaching Hospital, Ruhr-University Bochum, Recklinghausen, Germany.

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by absence or deficient activity of α-galactosidase A (α-Gal A) due to mutations in the α-galactosidase A gene (), leading to progressive accumulation of globotriaosylceramide (Gb3) in tissues and organs including heart, kidney, the eyes, vascular endothelium, the nervous system and the skin. Cardiac involvement is leading to fatal complications and reduced life expectancy. FD is treatable with disease-specific treatment (enzyme replacement therapy (ERT) or with chaperone therapy). Read More

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http://dx.doi.org/10.2147/TCRM.S247814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319521PMC

[HYpertension due to sympathetic hyperactivity after severe head injury].

Hipertens Riesgo Vasc 2020 Jun 27. Epub 2020 Jun 27.

Unidad de Gestión Clínica de Nefrología, Hospital Regional Universitario de Málaga, Universidad de Málaga, Instituto Biomédico de Investigación de Málaga (IBIMA), REDinREN (RD16/0009/0006), Málaga, España.

We present the case of a 34-year-old patient with severe head trauma and severe brain involvement. The patient deteriorated progressively and required several reinterventions for bleeding and brain herniation. We were consulted by neurosurgery due to irregular blood pressure control despite treatment with calcium antagonists. Read More

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http://dx.doi.org/10.1016/j.hipert.2020.06.001DOI Listing

Impact of lower body mass index on risk of all-cause mortality and infection-related death in Japanese chronic kidney disease patients.

BMC Nephrol 2020 Jun 30;21(1):244. Epub 2020 Jun 30.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Background: Several studies have reported that lower body mass index (BMI) is associated with high mortality in patients with chronic kidney disease (CKD). Rate of infection-related death in CKD patients is increasing. However, the relationship between BMI and infection-related death is unclear. Read More

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http://dx.doi.org/10.1186/s12882-020-01894-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325015PMC

Burden of Undiagnosed Type 2 Diabetes in Diabetic Kidney Disease: A Japanese Retrospective Cohort Study.

J Clin Med 2020 Jun 28;9(7). Epub 2020 Jun 28.

Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University, Fukushima 960-1295, Japan.

The risk of developing diabetic kidney disease (DKD) in patients with undiagnosed diabetes mellitus (UD) has never been evaluated. We studied the burden of UD on the risk of developing DKD in the Japanese population in a single-center retrospective cohort study. The patients with type 2 diabetes mellitus, but without DKD (estimated glomerular filtration rate (eGFR) < 60 mL/min/1. Read More

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http://dx.doi.org/10.3390/jcm9072028DOI Listing

Genetic Study in Korean Pediatric Patients with Steroid-Resistant Nephrotic Syndrome or Focal Segmental Glomerulosclerosis.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Department of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea.

Steroid-resistant nephrotic syndrome (SRNS) is one of the major causes of end-stage renal disease (ESRD) in childhood and is mostly associated with focal segmental glomerulosclerosis (FSGS). More than 50 monogenic causes of SRNS or FSGS have been identified. Recently, the mutation detection rate in pediatric patients with SRNS has been reported to be approximately 30%. Read More

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http://dx.doi.org/10.3390/jcm9062013DOI Listing

Relationship between Modified Body Mass Index and Prognosis of Renal Amyloid a Amyloidosis.

Sisli Etfal Hastan Tip Bul 2018 4;52(2):103-108. Epub 2018 Jun 4.

Department of Nephrology, Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.

Objectives: Overhydration occurs in nephrotic syndrome related to kidney involvement of amyloid A (AA) amyloidosis, which can cause an overestimation of body mass index (BMI). Modified BMI (mBMI, albumin×BMI) may be a better marker of nutritional status; therefore, we investigated the relationship between mBMI and the prognosis of patients with renal AA amyloidosis.

Methods: We retrospectively reviewed the data of patients with biopsy-proven renal AA amyloidosis who were followed up between January 2001 and May 2013. Read More

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http://dx.doi.org/10.14744/SEMB.2017.89410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315068PMC

Cardiorenal Amyloidosis.

J Assoc Physicians India 2020 Jul;68(7):74-76

Senior Resident, Family Medicine, Max Superspeciality Hospital, Saket, New Delhi.

Amyloidosis is a conglomeration of diseases due to production and deposition of amyloid, a proteinaceous substance, into organs, tissues, nerves and other places in the body affecting their normal function. This case report is of a 65 year old gentleman, resident of Bihar admitted with a short history of two months. He came with chief complaints of swelling in both lower limbs associated with heaviness in legs, shortness of breath, dizziness, fatigue and passage of frothy urine for two months. Read More

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Expression of angiogenic factor with G patch and FHA domains 1 (AGGF1) in placenta from patients with preeclampsia.

Folia Histochem Cytobiol 2020 Jun 30. Epub 2020 Jun 30.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Introduction: Preeclampsia (PE) is a major contributor to maternal and foetal morbidity and mortality worldwide. It manifests as high blood pressure and proteinuria in women at more than 20 weeks of gestation. Abnormal levels of anti- and pro-angiogenesis factors are known to be associated with PE. Read More

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http://dx.doi.org/10.5603/FHC.a2020.0016DOI Listing

Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Biochemistry, University of Hyderabad, Hyderabad, India

Introduction: Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). Previous studies have shown that AGEs contribute to glomerulosclerosis and proteinuria. Podocytes, terminally differentiated epithelial cells of the glomerulus and the critical component of the glomerular filtration barrier, express the receptor for AGEs (RAGE). Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326296PMC

Individualizing Treatment of Steroid-Resistant Nephrotic Syndrome: Registries to the Fore.

Clin J Am Soc Nephrol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.2215/CJN.08080520DOI Listing
June 2020
4.613 Impact Factor

Nephrotic syndrome due to preeclampsia before 20 weeks of gestation: a case report.

BMC Nephrol 2020 Jun 29;21(1):240. Epub 2020 Jun 29.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 216-8511, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan.

Background: Preeclampsia (PE) refers to the development of hypertension and new-onset proteinuria or progressive organ damage (especially kidney) in a previously normotensive pregnant women after 20 weeks of gestation. Thus, new-onset nephrotic syndrome due to PE before 20 weeks of gestation seems to be rare, making its diagnosis difficult in this time period.

Case Presentation: A 28-year-old woman presented with a new-onset nephrotic syndrome at 16 weeks of gestation. Read More

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http://dx.doi.org/10.1186/s12882-020-01876-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322849PMC

Baicalin alleviates adriamycin-induced focal segmental glomerulosclerosis and proteinuria by inhibiting the Notch1-Snail axis mediated podocyte EMT.

Life Sci 2020 Jun 26:118010. Epub 2020 Jun 26.

Bioactive Materials Key Lab of Ministry of Education, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address:

Podocyte injury is an early event and core in the development of focal segmental glomerular sclerosis (FSGS) that induces poor prognosis. Epithelial-mesenchymal transition (EMT) as a response of podocyte to injury leads to podocyte depletion and proteinuria. The abnormally reactivated NOTCH pathway may be involved in podocyte EMT. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118010DOI Listing

[Clinicopatological variants and risk factors for chronic kidney disease in rheumatoid arthritis].

Ter Arkh 2020 Jun 5;92(5):55-60. Epub 2020 Jun 5.

Sechenov First Moscow State Medical University (Sechenov University).

Recent studies have shown a high risk of chronic kidney disease and associated cardiovascular complications in patients with rheumatoid arthritis (RA), which determines the prognosis. However, the prevalence of chronic kidney disease (CKD) in RA has not been established in the Russians.

Aim: Study was to examine the prevalence, risk factors and histological variants of CKD in RA. Read More

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http://dx.doi.org/10.26442/00403660.2020.05.000604DOI Listing

May C-peptide index be a new marker to predict proteinuria in anemic patients with type 2 diabetes mellitus?

Endocr Regul 2020 Jan;54(1):1-5

Department of Endocrinology, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Objective: C-peptide is a reliable marker of beta cell reserve and is associated with diabetic complications. Furthermore, HbA1c level is associated with micro- and macro-vascular complications in diabetic patients. HbA1c measurement of diabetic patients with anemia may be misleading because HbA1c is calculated in percent by taking reference to hemoglobin measurements. Read More

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http://dx.doi.org/10.2478/enr-2020-0001DOI Listing
January 2020

Hook F Treatment for Stage IV Diabetic Nephropathy: Protocol for a Prospective, Randomized Controlled Trial.

Biomed Res Int 2020 10;2020:9181037. Epub 2020 Jun 10.

Department of Nephrology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.

Background: Diabetic nephropathy (DN) is a major cause of chronic kidney disease (CKD). There are no effective treatments to prevent or reverse the progression of DN. A preliminary study showed that glycosides from Hook F (TwHF) with valsartan decrease proteinuria in patients with DN. Read More

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http://dx.doi.org/10.1155/2020/9181037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303734PMC

Effects of low-dose meloxicam in cats with chronic kidney disease.

J Feline Med Surg 2020 Jun 29:1098612X20935750. Epub 2020 Jun 29.

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

Objectives: Meloxicam therapy may benefit cats with degenerative joint disease, and retrospective studies suggest it could slow kidney disease progression and increase survival. This study aimed to prospectively evaluate the renal effects of low-dose meloxicam treatment (0.02 mg/kg/day) over 6 months in cats with chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1177/1098612X20935750DOI Listing

Factors associated with kidney graft survival in pure antibody-mediated rejection at the time of indication biopsy: Importance of parenchymal injury but not disease activity.

Am J Transplant 2020 Jun 28. Epub 2020 Jun 28.

Alberta Transplant Applied Genomics Centre Edmonton, AB, Canada.

We studied the relative association of clinical, histologic, and molecular variables with risk of kidney transplant failure after an indication biopsy, both in all kidneys and in kidneys with pure antibody-mediated rejection (ABMR). From a prospective study of 1679 biopsies with histologic and molecular testing, we selected one random biopsy per patient (N=1120), including 321 with pure molecular ABMR. Diagnoses were associated with actuarial survival differences but not good predictions. Read More

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http://dx.doi.org/10.1111/ajt.16161DOI Listing