64,920 results match your criteria Proteinuria

Successful Reuse of Kidney Graft After Early Recurrence of Primary Focal and Segmental Glomerulosclerosis.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Nephrology, Dialysis, Transplantation, and Apheresis, Lille University, Regional and University Hospital Center of Lille, F-59037 Lille, France.

Primary focal and segmental glomerulosclerosis (pFSGS) frequently recurs after transplantation and is associated with a poor prognosis. We describe here the successful kidney graft reuse in an adult recipient, eight months after early pFSGS recurrence resistant to all available therapeutics. Patient 1, a 23-year-old man, followed for kidney failure secondary to pFSGS, was first transplanted in 2018 with a deceased donor graft. Read More

View Article and Full-Text PDF

The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID-19 viruses.

IUBMB Life 2021 Jun 12. Epub 2021 Jun 12.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The kidney is one of the main targets attacked by viruses in patients with a coronavirus infection. Until now, SARS-CoV-2 has been identified as the seventh member of the coronavirus family capable of infecting humans. In the past two decades, humankind has experienced outbreaks triggered by two other extremely infective members of the coronavirus family; the MERS-CoV and the SARS-CoV. Read More

View Article and Full-Text PDF

A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats.

J Pharmacol Sci 2021 Aug 24;146(4):192-199. Epub 2021 Apr 24.

Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

Metabolic syndrome (MetS) is associated with chronic kidney disease and proteinuria. Previously, we reported that a synthetic serine protease inhibitor, camostat mesilate (CM), mitigated hypertension and proteinuria in rodent disease models. The present study evaluated the anti-hypertensive and anti-proteinuric effects of CM in MetS model rats (SHR/ND mcr-cp). Read More

View Article and Full-Text PDF


Toxicon 2021 Jun 8. Epub 2021 Jun 8.

Programa de Pós-graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:

There is no consensus on whether serotherapy prevents acute kidney injury (AKI) and there is no pharmacotherapy to impede the disease. We aimed to elaborate an AKI model induced by the administration of Bothrops jararacussu (Bj) venom for preclinical studies. Male Wistar rats were randomly divided into 3 different groups: (1) Bj-IV: intravenous administration of 0. Read More

View Article and Full-Text PDF

VEGF-VEGFR2 inhibitor-associated hyaline occlusive glomerular microangiopathy: a Japanese single-center experience.

Clin Exp Nephrol 2021 Jun 11. Epub 2021 Jun 11.

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.

Background: Inhibitors of vascular endothelial growth factor (VEGF)-VEGF receptor 2 (VEGFR2) signaling, such as bevacizumab (Bmab), are used for the treatment of various advanced cancers. However, these inhibitors induce renal thrombotic microangiopathy (TMA). Recently, two European cohort studies showed a distinctive histopathological pseudothrombotic pattern different from TMA in Bmab-treated patients. Read More

View Article and Full-Text PDF

Urinary biomarkers of early renal injury in antiretroviral-naïve HIV-positive persons in Shanghai, China: comparison with the general population.

HIV Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Objectives: People living with HIV (PLWH) have a high risk of kidney injury. Measurement of serum creatinine, along with proteinuria, is not sensitive to detect early kidney injury. Here, we investigated novel urinary biomarkers of early renal injury in PLWH. Read More

View Article and Full-Text PDF

Membranous Nephropathy With Monoclonal IgM Lambda Deposits in a Patient With IgM Monoclonal Gammopathy: A Case Report.

Front Med (Lausanne) 2021 25;8:608741. Epub 2021 May 25.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan.

We report a case of membranous nephropathy with monoclonal immunoglobulin (Ig)M lambda deposits in a patient with IgM monoclonal gammopathy, in whom histological changes were observed on repeat renal biopsy. A 72-year-old Japanese woman was referred to our hospital because of massive proteinuria. A prominent increase in monoclonal IgM lambda level was identified, and she was diagnosed as having IgM monoclonal gammopathy of undetermined significance. Read More

View Article and Full-Text PDF

Changes in trends and outcomes of eclampsia: a success story from Qatar.

Qatar Med J 2019 20;2019(1):10. Epub 2019 Sep 20.

Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.

Preeclampsia and eclampsia are two hypertensive disorders of pregnancy that significantly contribute to higher morbidity and mortality rates. Eclampsia is the occurrence of seizures in patients with preeclampsia without any previous history of seizure disorders. The incidence and prevalence of eclampsia varies, and there is scarce literature about the prevalence and trends of eclampsia in the Arabian Gulf countries. Read More

View Article and Full-Text PDF
September 2019

Mitochondrial Complex I Deficiency among Egyptian Pediatric Patients with Steroid-Resistant Nephrotic Syndrome.

Int J Nephrol 2021 18;2021:6645373. Epub 2021 May 18.

Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.

Results: Positive consanguinity was a remarkable finding in 44 patients among the SRNS group (73%), compared with 33 patients among the SSNS group (55%). Complex I activity was significantly lower in the SRNS group (0.2657 ± 0. Read More

View Article and Full-Text PDF

IgA Vasculitis in a Lung Cancer Patient During Chemoradiotherapy.

Ther Clin Risk Manag 2021 3;17:571-575. Epub 2021 Jun 3.

Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan.

A 72-year-old man with locally advanced lung squamous cell carcinoma experienced red purpura on the lower legs and hematuria when the disease progressed during definitive chemoradiotherapy. He had renal dysfunction and proteinuria. Biopsy specimens of the skin lesion and kidney revealed immunoglobulin A vasculitis. Read More

View Article and Full-Text PDF

Leisure-time, occupational, and commuting physical activity and the risk of chronic kidney disease in a working population.

Sci Rep 2021 Jun 10;11(1):12308. Epub 2021 Jun 10.

Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Toyama, 1-21-1, Shinjuku-ku, Tokyo, 162-8655, Japan.

Physical activity has been linked to a lower risk of chronic kidney disease (CKD); however, evidence on the relationship between domain-specific physical activity and CKD is scarce. This study aimed to examine the risk of CKD in relation to leisure-time, occupational, and commuting physical activities in a large occupational cohort in Japan. Participants were 17,331 workers (20-65 years old) without CKD and were followed-up for a maximum period of 13 years. Read More

View Article and Full-Text PDF

Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage.

Am J Nephrol 2021 Jun 10:1-11. Epub 2021 Jun 10.

Cardiovascular Research, Research and Early Development, R&D Pharmaceuticals, Bayer AG, Wuppertal, Germany.

Introduction: The nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone and sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinical benefits in CKD patients with type 2 diabetes. Clinical data analyzing the potential value of a combination therapy are currently limited. We therefore investigated cardiorenal protection of respective mono- and combination therapy in a preclinical model of hypertension-induced end-organ damage. Read More

View Article and Full-Text PDF

Comparison of COVID-19 versus influenza on the incidence, features, and recovery from acute kidney injury in hospitalized United States Veterans.

Kidney Int 2021 Jun 7. Epub 2021 Jun 7.

Vanderbilt University Medical Center, Division of Nephrology and Hypertension, Vanderbilt Center for Kidney Disease (VCKD) and Integrated Program for Acute Kidney Injury Research (VIP-AKI), Nashville, TN; VA Tennessee Valley, Health Services Research and Development; VA Geriatrics Research Education and Clinical Center (GRECC), Tennessee Valley Health System (THVS), Veteran's Health Administration, Nashville, TN. Electronic address:

Acute kidney injury is a common complication in patients hospitalized with SARSCoV-2 (COVID-19), with prior studies implicating multiple potential mechanisms of injury. Although COVID-19 is often compared to other respiratory viral illnesses, few formal comparisons of these viruses on kidney health exist. In this retrospective cohort study, we compared the incidence, features, and outcomes of acute kidney injury among Veterans hospitalized with COVID-19 or influenza and adjusted for baseline conditions using weighted comparisons. Read More

View Article and Full-Text PDF

Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus.

J Immunol 2021 Jun 9. Epub 2021 Jun 9.

Department of Discovery Biology, Bristol Myers Squibb, Princeton, NJ;

Systemic lupus erythematosus (SLE) is associated with an IL-2-deficient state, with regulatory T cells (Tregs) showing diminished immune regulatory capacity. A low dose of IL-2 has shown encouraging clinical benefits in SLE patients; however, its clinical utility is limited because of the requirement of daily injections and the observation of increase in proinflammatory cytokines and in non-Tregs. We recently showed that a fusion protein of mouse IL-2 and mouse IL-2Rα (CD25), joined by a noncleavable linker, was effective in treating diabetes in NOD mice by selectively inducing Treg expansion. Read More

View Article and Full-Text PDF

Epidemiology of chronic kidney disease of undetermined aetiology in Taiwanese farmers: a cross-sectional study from Changhua Community-based Integrated Screening programme.

Occup Environ Med 2021 Jun 9. Epub 2021 Jun 9.

Institute of Occupational and Environmental Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan

Objectives: Chronic kidney disease of undetermined or non-traditional aetiology (CKDu or CKDnT) has been reported in Mesoamerica among farmers under heat stress. Epidemiological evidence was lacking in Asian countries with similar climatic conditions. The objective of this study was to investigate the prevalence of CKDu and possible risk factors. Read More

View Article and Full-Text PDF

Membranous nephropathy associated with multicentric Castleman's disease that was successfully treated with tocilizumab: a case report and review of the literature.

BMC Nephrol 2021 Jun 9;22(1):216. Epub 2021 Jun 9.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Background: Multicentric Castleman's disease is a life-threatening disorder involving a systemic inflammatory response and multiple organ failure caused by the overproduction of interleukin-6. Although renal complications of Castleman's disease include AA amyloidosis, thrombotic microangiopathy, and membranoproliferative glomerulonephritis, membranous nephropathy is relatively rare. We experienced a case of secondary membranous nephropathy associated with Castleman's disease. Read More

View Article and Full-Text PDF

Periprocedural Course of Proteinuria After Transcatheter Aortic Valve Implantation: Substudy From the POPular TAVI Trial.

Circ Cardiovasc Interv 2021 Jun 10:CIRCINTERVENTIONS120010404. Epub 2021 Jun 10.

Department of Cardiology, St Antonius Hospital, Nieuwegein, the Netherlands. (J.B., V.J.N., D.J.v.G., M.J.S., B.J.W.M.R., L.T., J.M.t.B.).

View Article and Full-Text PDF

CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

FASEB J 2021 Jul;35(7):e21711

Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.

Podocyte injury is a major determinant of focal segmental glomerular sclerosis (FSGS) and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance for the treatment of FSGS. CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be expressed in vascular endothelial cells during embryogenesis and is also implicated in tumor angiogenesis. Read More

View Article and Full-Text PDF

A systematic review and meta-analysis of cell-based interventions in experimental diabetic kidney disease.

Stem Cells Transl Med 2021 Jun 9. Epub 2021 Jun 9.

Kern Center Affiliate, Mayo Clinic, Rochester, Minnesota, USA.

Regenerative, cell-based therapy is a promising treatment option for diabetic kidney disease (DKD), which has no cure. To prepare for clinical translation, this systematic review and meta-analysis summarized the effect of cell-based interventions in DKD animal models and treatment-related factors modifying outcomes. Electronic databases were searched for original investigations applying cell-based therapy in diabetic animals with kidney endpoints (January 1998-May 2019). Read More

View Article and Full-Text PDF

[A secondary focal segmental glomerulosclerosis due to prematurity].

Andes Pediatr 2021 Apr;92(2):263-267

Departamento de Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Both premature birth and low birth weight compromise nephron development. The lower nephron endowment is subjected to compensatory hyperfiltration that overloads the glomeruli and leads to the vicious circle of progressive deterioration of renal function.

Objective: To emphasize the risk of renal involvement in this susceptible population by describing the case of a patient with long-term follow-up. Read More

View Article and Full-Text PDF

Circulating Fibroblast Growth Factor-2 precipitates HIV-nephropathy in mice.

Dis Model Mech 2021 Jun 9. Epub 2021 Jun 9.

Child Health Research Center, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.

Over 80% of all children living with HIV reside in Africa and are at risk of developing HIV-associated nephropathy (HIVAN). Once HIVAN is established in children, it is difficult to revert its progression to chronic kidney failure even using antiretroviral drugs. Therefore, new therapeutic strategies are needed. Read More

View Article and Full-Text PDF

Evaluation of renal injury in children with a solitary functioning kidney.

Turk Arch Pediatr 2021 1;56(3):219-223. Epub 2021 May 1.

Division of Pediatric Nephrology, İstanbul Medeniyet University School of Medicine, İstanbul, Turkey.

Objective: Children with a solitary functioning kidney have an increased risk of developing renal injury that is hypothesized to be caused by glomerular hyperfiltration. In this study, we aimed to assess the early signs of renal injury and ambulatory blood pressure profiles in children with a solitary functioning kidney.

Materials And Methods: Data of children with normal office blood pressure measurement and a solitary functioning kidney were reviewed (serum creatinine and urine albumin and β2 microglobulin excretions), and 23 age-, weight-, and height-matched healthy children were considered as a control group. Read More

View Article and Full-Text PDF

Hyperuricemia, urate-lowering therapy, and kidney outcomes: a systematic review and meta-analysis.

Ther Adv Musculoskelet Dis 2021 25;13:1759720X211016661. Epub 2021 May 25.

Division of Clinical Immunology and Rheumatology, Department of Medicine at the School of Medicine and the Department of Epidemiology at the School of Public Health, University of Alabama at Birmingham, Faculty Office Tower 805B, 510 20th Street S., Birmingham, AL 35294-0022, USA.

Background: Contradictory evidence exists for association of hyperuricemia and kidney function. To investigate the association of hyperuricemia and kidney function decline (hyperuricemia question) and effect of urate-lowering therapies (ULTs) on kidney function (ULT question), we performed a systematic review and meta-analysis.

Methods: , , , and were searched from inception to July 2020. Read More

View Article and Full-Text PDF

A Synergy Between Endotoxin and (1→3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus.

J Inflamm Res 2021 1;14:2333-2352. Epub 2021 Jun 1.

Immunology Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: The translocation of organismal molecules from gut into blood circulation might worsen the disease severity of lupus through the induction of neutrophil extracellular traps (NETs).

Methods: An impact of lipopolysaccharide (LPS) and (1→3)-β-D-glucan (BG), components of gut bacteria and fungi, respectively, on NETs formation, was explored in lupus models, Fc gamma receptor IIB deficiency (FcGRIIB-/-) and Pristane injection, using administered dextran sulfate solution induced colitis (-DSS) model.

Results: Severity of -DSS in FcGRIIB-/- mice was more prominent than wild-type (WT) and Pristane mice as indicated by (i) colonic NETs using immunofluorescence of Ly6G, myeloperoxidase (MPO) and neutrophil elastase (NE) together with expression of and , (ii) colonic immunoglobulin (Ig) deposition (immunofluorescence), (iii) gut-leakage by FITC-dextran assay, endotoxemia and serum BG, (iv) systemic inflammation (neutrophilia, serum cytokines, serum dsDNA and anti-dsDNA) and (v) renal injury (proteinuria, glomerular NETs and Ig deposition). Read More

View Article and Full-Text PDF

Chronic kidney disease ten years after pediatric allogeneic hematopoietic stem cell transplantation.

Kidney Int 2021 Jun 5. Epub 2021 Jun 5.

Willem-Alexander Children's Hospital,Department of Pediatrics,Leiden University Medical Center,Leiden,The Netherlands.

Chronic kidney disease (CKD) is an important sequela of hematopoietic stem cell transplantation (HSCT), but data regarding CKD after pediatric HSCT are limited. In this single center cohort study, we evaluated the estimated glomerular filtration rate (eGFR) dynamics, proteinuria and hypertension in the first decade after HSCT and assessed risk factors for CKD in 216 pediatric HSCT survivors, transplanted 2002-2012. The eGFR decreased from a median of 148 to 116 ml/min/1. Read More

View Article and Full-Text PDF

Acute kidney injury in patients with Visceral Leishmaniasis in Northwest Ethiopia.

PLoS One 2021 8;16(6):e0252419. Epub 2021 Jun 8.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Visceral Leishmaniasis (VL) is a neglected tropical disease endemic to several countries including Ethiopia. Outside of Africa, kidney involvement in VL is frequent and associated with increased mortality. There is however limited data on acute kidney injury (AKI) in VL patients in East-Africa, particularly in areas with high rates of HIV co-infection. Read More

View Article and Full-Text PDF

Pre-operative proteinuria, postoperative acute kidney injury and mortality: A systematic review and meta-analysis.

Eur J Anaesthesiol 2021 Jul;38(7):702-714

From the Department of Anesthesiology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City (C-YC, M-CK, H-YL), Department of Anesthesiology, School of Medicine, Tzu Chi University, Hualien (C-YC, M-CK, H-YL), Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City (Y-JC), Department of Physical Medicine and Rehabilitation, School of Medicine, Tzu Chi University, Hualien (Y-JC), Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City (Y-LC, M-YW) and Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien, Taiwan (Y-LC, M-YW).

Objective: To investigate the association of pre-operative proteinuria with postoperative acute kidney injury (AKI) development as well as the requirement for a renal replacement therapy (RRT) and mortality at short-term and long-term follow-up.

Background: Postoperative AKI is associated with surgical morbidity and mortality. Pre-operative proteinuria is potentially a risk factor for postoperative AKI and mortality. Read More

View Article and Full-Text PDF

Influence of anti-TNF-α treatment on liver and kidney functions in patients with ankylosing spondylitis: A retrospective longitudinal study.

Eur J Rheumatol 2021 May 24. Epub 2021 May 24.

Division of Rheumatology, Department of Internal Medicine, Health Sciences University, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Objective: To retrospectively evaluate the effect of anti-tumor necrosis factor-alpha (TNF-α) drugs on hepatic and renal functions in patients with ankylosing spondylitis (AS).

Methods: A total of 148 patients (89 male, 59 female) who were followed up for a minimum duration of 1 year on newly started anti TNF-α therapy were included. Patients were divided into 5 groups based on the TNF-α treatment received. Read More

View Article and Full-Text PDF

PKD2 gene variants in Chinese patients with autosomal dominant polycystic kidney disease.

Clin Genet 2021 Jun 7. Epub 2021 Jun 7.

Department of Nephrology, Changzheng Hospital, Naval Medical University, Shanghai, China.

PKD2 gene variants account for 4.5% to 20% of patients with autosomal dominant polycystic kidney disease (ADPKD). Little is known about the clinical characteristics of PKD2 variants in Chinese patients with ADPKD. Read More

View Article and Full-Text PDF

Evaluation of appropriate treatment for IgA nephropathy with mild proteinuria and normal renal function.

Clin Exp Nephrol 2021 Jun 8. Epub 2021 Jun 8.

Department of Nephrology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: Tonsillectomy and steroid pulse therapy (TSP) for immunoglobulin A nephropathy (IgAN) is frequently employed in many Japanese institutions; however, performing this invasive treatment in patients with mild IgAN is controversial. This study aimed to evaluate the appropriate treatment for IgAN patients with mild proteinuria.

Methods: In this retrospective cohort analysis, 122 IgAN patients with mild proteinuria (0. Read More

View Article and Full-Text PDF