59,840 results match your criteria Proteinuria


Most common histopathological patterns of the Minas Gerais Association of the Centers of Nephrology.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):441-445. Epub 2019 Apr 11.

MD, Nephrologist, MSc in Science from Unifesp, São Paulo/ São João de Deus Hospital - Brasil.

Introduction: We analyzed the distribution and frequency of glomerular diseases in patients biopsied between 1992 and 2016 in centers that make up the AMICEN (Minas Gerais Association of Nephrology Centers).

Methods: We analyzed the biopsy reports of patients from 9 AMICEN nephrology centers. We took note of their age, gender, ultrasound use, post-biopsy resting time, whether the kidney was native or a graft, number of glomeruli and indication for the biopsy. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.441DOI Listing

Salidroside ameliorates Adriamycin nephropathy in mice by inhibiting β-catenin activity.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, China.

Salidroside is a major phenylethanoid glycoside in Rhodiola rosea L., a traditional Chinese medicine, with multiple biological activities. It has been shown that salidroside possesses protective effects for alleviating diabetic renal dysfunction, contrast-induced-nephropathy and other kidney diseases. Read More

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http://dx.doi.org/10.1111/jcmm.14340DOI Listing

Effect of LDL apheresis for nephrotic idiopathic membranous nephropathy as initial induction therapy.

Ther Apher Dial 2019 Apr 17. Epub 2019 Apr 17.

Department of Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan.

Low-density lipoprotein apheresis (LDL-A) has been used for nephrotic syndrome (NS) by focal segmental glomerulosclerosis in Japan. Idiopathic membranous nephropathy (iMN) can also cause treatment-resistant NS. Therefore we investigated the effect of LDL-A during initial induction for it. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1744-9987.12
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http://dx.doi.org/10.1111/1744-9987.12811DOI Listing
April 2019
1 Read

Impact of Using Alternative Graft Function Endpoints: A Secondary Analysis of a Kidney Transplant Trial.

Transplant Direct 2019 Apr 19;5(4):e439. Epub 2019 Mar 19.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.

Background: Nephrology trials assessing the impact of interventions on "standard" outcomes, such as doubling of creatinine, end-stage renal disease (ESRD), and/or death, are difficult to conduct given the time required for endpoints to accrue. The objective of this study was to determine if using lesser declines in kidney function would alter the interpretation of a previous randomized controlled trial.

Methods: This study was a secondary analysis of a kidney transplant trial comparing the use of a 40% or greater, 30% or greater, or 20% or greater decline in estimated glomerular filtration rate (eGFR) as a substitute for doubling of serum creatinine. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445653PMC

Nephrotic range proteinuria and metabolic alkalosis in Takayasu arteritis.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Internal Medicine, Okinawa Chubu Hospital, Uruma, Japan.

Nephrotic range proteinuria and metabolic alkalosis are unusual findings in large vessel vasculitis. In this case, renovascular hypertension with unilateral renal artery stenosis in Takayasu arteritis was complicated by nephrotic range proteinuria. Symptoms resolved after angioplasty, although non-nephrotic proteinuria persisted. Read More

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http://dx.doi.org/10.1136/bcr-2018-228637DOI Listing

Histopathologic Features that Predict Transplant Glomerulopathy Progression in a Chinese Cohort.

Am J Nephrol 2019 Apr 16;49(6):425-434. Epub 2019 Apr 16.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Medical School of Nanjing University, Nanjing, China,

Background: Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain.

Methods: A single-center retrospective cohort with biopsy-proven TG was investigated. Read More

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http://dx.doi.org/10.1159/000500043DOI Listing

Effects of metreleptin on proteinuria in patients with lipodystrophy.

J Clin Endocrinol Metab 2019 Apr 16. Epub 2019 Apr 16.

Diabetes, Endocrinology, and Obesity Branch; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Institutes of Health (NIH); Bethesda, MD.

Context: Patients with lipodystrophy have high prevalence of proteinuria.

Objective: To assess kidney disease in patients with generalized (GLD) versus partial lipodystrophy (PLD), and effects metreleptin on proteinuria in patients with lipodystrophy.

Design/setting/patients/intervention: Prospective, open-label studies of metreleptin treatment in patients with GLD and PLD at the National Institutes of Health, Bethesda, MD. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2019-00200DOI Listing
April 2019
1 Read

The efficacy and safety of immunosuppressive agents plus steroids compared with steroids alone in the treatment of Henoch-Schönlein purpura nephritis: A meta-analysis.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the most severe symptom of Henoch-Schönlein purpura. The role of immunosuppressive agents combined with steroids is controversial in treating HSPN. Our meta-analysis was performed to assess the efficacy and safety of the combined therapy in the treatment of HSPN compared with steroids alone. Read More

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http://dx.doi.org/10.1007/s11255-019-02092-7DOI Listing

Baseline urinary KIM-1 concentration in detecting acute kidney injury should be interpreted with patient pre-existing nephropathy.

Pract Lab Med 2019 May 7;15:e00118. Epub 2019 Mar 7.

Discipline of Laboratory Medicine, Eastern Health Authority, 300 Prince Philip Dr, St. John's, NL, Canada.

Objectives: To determine whether pre-existing nephropathy impacts urinary KIM-1 levels, urinary KIM-1 were measured in patients with normal kidney filtration function but either with or without proteinuria. The reference intervals of urinary KIM-1 in adults with normal kidney filtration function but without urine proteinuria were established.

Design And Methods: 188 urine samples were obtained from adults with normal kidney filtration. Read More

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http://dx.doi.org/10.1016/j.plabm.2019.e00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447747PMC

Renoprotective Effect of Against Proteinuria and Apoptosis Induced by Adriamycin in Rat.

J Pharmacopuncture 2019 Mar 31;22(1):35-40. Epub 2019 Mar 31.

Department of Physiology, faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Adriamycin (ADR) is an important anti-cancer drug which can cause renal toxicity. Given the known anti-inflammatory and antioxidant effects of ), the aim of this study was to determine the effects of hydroalcoholic extract of on ADR- induced nephropathy in rats.

Methods: Fifty male Wistar albino rats were randomly divided into 5 groups including: control, ADR (5 mg/kg), ADR + (600 and 1200 mg/kg) and (1200 mg/kg). Read More

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http://koreascience.or.kr/journal/view.jsp?kj=DHOCBS&py=
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http://dx.doi.org/10.3831/KPI.2019.22.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461299PMC
March 2019
1 Read

Clinicopathological spectrum of renal parenchymal involvement in B-cell lymphoproliferative disorders.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Department of Nephrology and Renal Transplantation, Centre Hospitalier Universitaire, Université de Poitiers, Poitiers, France; CNRS UMR 7276, INSERM UMR 1262, Université de Limoges, Limoges, France; INSERM CIC 1402, Centre Hospitalier Universitaire, Poitiers, France.

The clinicopathological characteristics of kidney infiltration in B-cell lymphoproliferative disorders remain poorly described. We retrospectively studied 52 adults with biopsy-proven malignant B-cell kidney infiltration, including Waldenström's macroglobulinemia (n=21), chronic lymphocytic leukemia (n=11), diffuse large B-cell lymphoma (DLBCL) (n=8), other lymphoma (n=11), and multiple myeloma (n=1). Kidney disease varied according to the underlying lymphoproliferative disorder. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.027DOI Listing

Re: Bakkum et al. "Effects of psychological stress on proteinuria in childhood steroid-sensitive nephrotic syndrome".

J Psychosom Res 2019 Apr 9. Epub 2019 Apr 9.

Health Psychology Section, Psychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychores.2019.04.005DOI Listing

Hypertension In Chronic Kidney Disease: Novel Insights.

Curr Hypertens Rev 2019 Apr 15. Epub 2019 Apr 15.

Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki. Greece.

Management of arterial hypertension in patients with chronic kidney disease (CKD) remains a major challenge due to its high prevalence and its associations with cardiovascular disease (CVD) and CKD progression. Several clinical trials and meta-analyses have demonstrated that aggressive treatment of hypertension in patients with and without CKD lowers the risk of CVD and all-cause mortality, nevertheless the effects of blood pressure (BP) lowering in terms of renal protection or harm remain controversial. Both home and ambulatory BP estimation have shown that patients with CKD display abnormal BP patterns outside of the office and further investigation is required, so as to compare the association of ambulatory versus office BP measurements with hard outcomes and adjust treatment strategies accordingly. Read More

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http://dx.doi.org/10.2174/1573402115666190415153554DOI Listing
April 2019
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[HELLP syndrome and hemolytic uremic syndrome during pregnancy: two disease entities, same causation. Case report and literature review].

G Ital Nefrol 2019 Apr;36(2)

Centro per la Cura e lo Studio della Sindrome Emolitico-Uremica. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano.

Thrombotic microangiopathies (TMA) are a group of diseases that can complicate pregnancy and threaten the lives of both the mother and the fetus. Several conditions can lead to TMA, including thrombotic thrombocytopenic purpura (TTP), HELLP syndrome and hemolytic uremic syndrome (HUS). We describe the case of a 39-year-old woman who presented a HELLP syndrome in the immediate postpartum period. Read More

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April 2019
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Study Profile: Japan Trial in High-risk Individuals to Accelerate their Referral to Physicians (J-HARP) - a Nurse-led, Community-based Prevention Program of Lifestyle-related Disease.

J Epidemiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Public Health, Department of Social Medicine, Graduate School of Medicine Osaka University.

Background: It is uncertain whether the health counselling after community-based health checkups for high-risk individuals of lifestyle-related disease accelerates their referral to physicians.

Methods: We performed a clustered randomized controlled trial of untreated high-risk individuals aged 40 to 74 years, screened from the annual health checkup in 2014 and 2015 under the national health insurance in 43 municipalities around Japan, assigning 21 intervention and 22 usual care municipalities. The high-risk conditions were severe forms of hypertension, diabetes, dyslipidemia for men and proteinuria. Read More

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http://dx.doi.org/10.2188/jea.JE20180194DOI Listing

Person-Centered Care for Older Adults With Kidney Disease: Core Curriculum 2019.

Am J Kidney Dis 2019 Apr 11. Epub 2019 Apr 11.

Division of Nephrology, Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, WA.

This Core Curriculum article models a person-centered approach to care for older adults with kidney disease. We provide background information on the principles of person-centered care and outline ways in which this approach contrasts with the more disease-based approaches that dominate current medical education and practice. Using hypothetical cases, we discuss 3 clinical scenarios that arise commonly when caring for older adults with kidney disease: (1) a moderate reduction in estimated glomerular filtration rate, (2) new-onset nephrotic-range proteinuria, and (3) the prospect of starting dialysis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.01.038DOI Listing
April 2019
5.900 Impact Factor

Geniposide alleviates lipopolysaccharide-caused apoptosis of murine kidney podocytes by activating Ras/Raf/MEK/ERK-mediated cell autophagy.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1524-1532

a Department of Nephrology , Jining No.1 People's Hospital , Jining , China.

Proteinuria is one of the most important clinical features of nephrotic syndrome (NS). Injury of podocyte has been proved to contribute to the occurrence of proteinuria. This study explored the effects of geniposide (GEN) on lipopolysaccharide (LPS)-caused murine kidney podocyte MPC5 apoptosis and autophagy. Read More

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http://dx.doi.org/10.1080/21691401.2019.1601630DOI Listing
December 2019

Challenges in Managing Pregnancy in Underserved Women with Chronic Kidney Disease.

Am J Nephrol 2019 Apr 12;49(5):386-396. Epub 2019 Apr 12.

Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, University of Guadalajara Health Sciences Center, Guadalajara, Mexico,

Background: Chronic kidney disease (CKD) is a global public health problem and is linked to adverse outcomes during pregnancy; the high prevalence of CKD (3-6%) in women of childbearing age is of particular relevance in emerging countries where CKD prevalence is higher and resources are limited. Although CKD is a public health problem in Mexico, there is scant information on outcomes in pregnant CKD women in this country. We report maternal-fetal outcomes in a prospective cohort of poor, CKD pregnant women, and compare results with those of pregnant women without CKD. Read More

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https://www.karger.com/Article/FullText/499964
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http://dx.doi.org/10.1159/000499964DOI Listing
April 2019
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Early Switch to Mammalian Target of Rapamycin Inhibitors Is a Sustainable Treatment Approach in Renal Transplant Recipients: 7-Year Results.

Transplant Proc 2019 Feb 8. Epub 2019 Feb 8.

Department of Nephrology, Sakarya University Faculty of Medicine, Sakarya, Turkey.

Objective: The aim of this study was to investigate the safety and sustainability of mammalian target of rapamycin inhibitor (m-TORi)-based treatment protocols in renal transplant patients.

Methods: We retrospectively evaluated a total of 206 patients who were switched to low-dose calcineurin inhibitors (CNI) + m-TORi or mycophenolate mofetil (MMF) + m-TORi treatment protocols in the first 3 months of renal transplantation between January 2010 and August 2011 in our center. Demographic and laboratory features of the patients were recorded. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.098DOI Listing
February 2019

Evaluating a New International Risk-Prediction Tool in IgA Nephropathy.

JAMA Intern Med 2019 Apr 13. Epub 2019 Apr 13.

Division of Nephrology, University of Toronto, Toronto, Ontario, Canada.

Importance: Although IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, there is no validated tool to predict disease progression. This limits patient-specific risk stratification and treatment decisions, clinical trial recruitment, and biomarker validation.

Objective: To derive and externally validate a prediction model for disease progression in IgAN that can be applied at the time of kidney biopsy in multiple ethnic groups worldwide. Read More

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http://dx.doi.org/10.1001/jamainternmed.2019.0600DOI Listing
April 2019
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Autologous Hematopoietic Stem Cell Transplantation for Refractory Lupus Nephritis.

Clin J Am Soc Nephrol 2019 Apr 12. Epub 2019 Apr 12.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Background And Objectives: Our study evaluated the efficiency and safety of autologous hematopoietic stem cell transplantation treatment for patients with refractory lupus nephritis.

Design, Setting, Participants, & Measurements: From July 2011 to January 2015, a total of 22 patients with refractory lupus nephritis were enrolled in this study. Peripheral blood stem cells were mobilized with cyclophosphamide and granulocyte colony stimulating factor and reinfused after treatment with cyclophosphamide and antithymocyte globulin. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.10570918
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http://dx.doi.org/10.2215/CJN.10570918DOI Listing
April 2019
1 Read

The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis.

PLoS Med 2019 Apr 12;16(4):e1002783. Epub 2019 Apr 12.

School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: Most pregnancy hypertension estimates in less-developed countries are from cross-sectional hospital surveys and are considered overestimates. We estimated population-based rates by standardised methods in 27 intervention clusters of the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials.

Methods And Findings: CLIP-eligible pregnant women identified in their homes or local primary health centres (2013-2017). Read More

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http://dx.doi.org/10.1371/journal.pmed.1002783DOI Listing
April 2019
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IgA Nephropathy Flare-Up Mimicking Staphylococcus Post-Infection Glomerulonephritis in Patient with Staphylococcus Aureus Infection Treated with Cefazolin: A Case Report and Brief Review of the Literature.

Am J Case Rep 2019 Apr 12;20:508-510. Epub 2019 Apr 12.

Department of Pharmacy Services, Piedmont Columbus Regional Healthcare System, Columbus, GA, USA.

BACKGROUND Glomerulonephritis (GN) associated with post staphylococcus infection (PSIGN) and high serum immunoglobulin A (IgA) has been reported recently. Patients with GN after infection with underlying IgA nephropathy create a challenge to determine the etiology of GN. Therefore, treatment should be accordingly, with steroids used if the IgA nephropathy flare-up is determined to be the etiology. Read More

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http://dx.doi.org/10.12659/AJCR.914935DOI Listing
April 2019
5 Reads

Assessment of Postdonation Outcomes in US Living Kidney Donors Using Publicly Available Data Sets.

JAMA Netw Open 2019 Apr 5;2(4):e191851. Epub 2019 Apr 5.

Bakar Computational Health Sciences Institute, University of California, San Francisco.

Importance: There are limited resources providing postdonation conditions that can occur in living donors (LDs) of solid-organ transplant. Consequently, it is difficult to visualize and understand possible postdonation outcomes in LDs.

Objective: To assemble an open access resource that is representative of the demographic characteristics in the US national registry, maintained by the Organ Procurement and Transplantation Network and administered by the United Network for Organ Sharing, but contains more follow-up information to help to examine postdonation outcomes in LDs. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.1851DOI Listing
April 2019
3 Reads

Minimal change disease and malaria.

Clin Kidney J 2019 Apr 18;12(2):245-247. Epub 2018 Apr 18.

Cleveland Clinic Akron General/Akron Nephrology Associates, Akron, OH, USA.

Malaria is a tropical disease secondary to the parasite with clinical features ranging from febrile illness to acute renal failure and further renal sequelae. We present a case of a woman minimal change disease secondary to who developed nephrotic range proteinuria and ultimately acute renal failure requiring renal replacement therapy. With proper treatment of her malarial infection as well as long-term renal replacement therapy, she made a full recovery. Read More

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https://academic.oup.com/ckj/article/12/2/245/4976473
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http://dx.doi.org/10.1093/ckj/sfy029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452177PMC
April 2019
3 Reads

Higher serum galactose-deficient immunoglobulin A1 concentration is associated with stronger mesangial cellular inflammatory response and more severe histologic findings in immunoglobulin A nephropathy.

Clin Kidney J 2019 Apr 3;12(2):232-238. Epub 2018 Aug 3.

Department of Biomedicine, University of Basel, Basel, Switzerland.

Background: Galactose-deficient immunoglobulin A1 (Gd-IgA1) is known to play a key role in the pathogenesis of IgA nephropathy (IgAN). We aimed to evaluate whether serum Gd-IgA1 is associated with activation of mesangial cells in individual patients and how this affects the clinical and histologic parameters.

Methods: Serum samples and clinical and histologic data were collected in the University Hospital Basel and Hammersmith Hospital, London. Read More

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http://dx.doi.org/10.1093/ckj/sfy068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452211PMC
April 2019
1 Read

The clinical significance of plasma CFHR 1-5 in lupus nephropathy.

Immunobiology 2019 Apr 3. Epub 2019 Apr 3.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders (Xiangya), Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. Electronic address:

A deficiency of complement factor H may lead to excessive consumption of C3 and an increase in C3b deposition, which are important pathological characteristics of lupus nephritis. Complement factor H-related proteins (CFHRs), comprising CFHR1 to CFHR5 (CFHR1-5), are members of the wider factor H/CFHR family. Their role in lupus nephritis remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183017
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http://dx.doi.org/10.1016/j.imbio.2019.03.005DOI Listing
April 2019
2 Reads

Effectiveness and safety of sofosbuvir-based therapy against chronic hepatitis C infection after successful kidney transplantation.

Transpl Infect Dis 2019 Apr 10:e13090. Epub 2019 Apr 10.

School of Medicine in Katowice, Dept. of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, Poland.

Background: Direct-acting antivirals (DAAs), including sofosbuvir (SOF), are recommended for treatment of chronic hepatitis C virus (HCV) infection. However, few studies have investigated the effectiveness and safety of new DAAs in kidney transplant recipients (KTRs).

Objectives: To assess the effectiveness and safety of SOF-based therapy in stable KTRs. Read More

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http://dx.doi.org/10.1111/tid.13090DOI Listing
April 2019
1 Read

Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes.

Front Immunol 2019 27;10:571. Epub 2019 Mar 27.

Department of Translational Medicine and Therapeutics, Bart's and The London School of Medicine and Dentistry, The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.

Annexin A1 (ANXA1) is an endogenously produced anti-inflammatory protein, which plays an important role in the pathophysiology of diseases associated with chronic inflammation. We demonstrate that patients with type-2 diabetes have increased plasma levels of ANXA1 when compared to normoglycemic subjects. Plasma ANXA1 positively correlated with fatty liver index and elevated plasma cholesterol in patients with type-2 diabetes, suggesting a link between aberrant lipid handling, and ANXA1. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446914PMC
March 2019
1 Read

Comparison and development of machine learning tools in the prediction of chronic kidney disease progression.

J Transl Med 2019 Apr 11;17(1):119. Epub 2019 Apr 11.

Department of Nephrology, Huadong Hospital Affiliated To Fudan University, Shanghai, 200040, China.

Background: Urinary protein quantification is critical for assessing the severity of chronic kidney disease (CKD). However, the current procedure for determining the severity of CKD is completed through evaluating 24-h urinary protein, which is inconvenient during follow-up.

Objective: To quickly predict the severity of CKD using more easily available demographic and blood biochemical features during follow-up, we developed and compared several predictive models using statistical, machine learning and neural network approaches. Read More

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http://dx.doi.org/10.1186/s12967-019-1860-0DOI Listing
April 2019
3.930 Impact Factor

Renal tubular P-glycoprotein expression is reduced in plasma cell disorders.

Kidney Res Clin Pract 2019 Apr 8. Epub 2019 Apr 8.

Division of Nephrology, Department of Internal Medicine, Dokuz Eylül University, Izmir, Turkey.

Background: : P-glycoprotein (P-gp) transports many chemicals that vary greatly in their structure and function. It is normally expressed in renal proximal tubular cells. We hypothesized that P-gp expression influences light chain excretion. Read More

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http://dx.doi.org/10.23876/j.krcp.18.0134DOI Listing

Angiotensin blockade attenuates diabetic nephropathy in hypogonadal adult male rats.

Can J Physiol Pharmacol 2019 Apr 10. Epub 2019 Apr 10.

Faculty of Medicine- Suez Canal University, Pharmacology , Pharmacology department- Faculty of Medicine- Suez Canal University , Ismailia, Egypt , +2-064 ;

This study examined the effect of the aromatase inhibitor letrozole (0.5 mg/kg) alone or in combination with the angiotensin-receptor blocker valsartan (30 mg/kg) against streptozocin-induced diabetic nephropathy (DN) in hypogonadal (HG) rats for 12 weeks. First, we tested the HG effect on hormone levels, inflammatory cytokines, and oxidative stress in non-diabetic (ND) and diabetic (D) rats. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0572DOI Listing
April 2019
1 Read

In utero sFlt-1 exposure differentially affects gene expression patterns in fetal liver.

J Dev Orig Health Dis 2019 Apr 10:1-9. Epub 2019 Apr 10.

1Department of Obstetrics and Gynecology,University of Groningen,University Medical Center Groningen,The Netherlands.

The soluble fms-like tyrosine kinase factor 1 (sFlt-1) is a major contributor to antiangiogenesis during preeclampsia. However, little is known about the effects of sFlt-1 on fetal health. In this study we aim to evaluate the effects of the sFlt-1 concentration during pregnancy on fetal liver physiology. Read More

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http://dx.doi.org/10.1017/S2040174418000831DOI Listing
April 2019
2 Reads

Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL).

Front Pediatr 2019 22;7:88. Epub 2019 Mar 22.

Pediatric Nephrology Unit, Department of Pediatrics, Children's Hospital, Geneva University Hospital, Geneva, Switzerland.

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is increasingly diagnosed during childhood by the presence of renal cysts in patients with a positive familial history. No curative treatment is available and early detection and diagnosis confronts pediatricians with the lack of early markers to decide whether to introduce renal-protective agents and prevent the progression of renal failure. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a tubular protein that has been recently proposed as an early biomarker of renal impairment in the ADPKD adult population. Read More

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http://dx.doi.org/10.3389/fped.2019.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439434PMC
March 2019
1 Read

Simplified Algorithm for Evaluation of Proteinuria in Clinical Practice: How should A Clinician Approach?

Int J Prev Med 2019 5;10:35. Epub 2019 Mar 5.

Department of Pediatrics, Section of Nephrology, Rush University Medical Center, Chicago, Illinois, USA.

Background: Proteinuria is a common laboratory finding among children and adolescents. It can be identified as either a transient or a persistent finding and can represent a benign condition or a serious disease.

Methods: Pertinent medical literature for asymptomatic proteinuria in children and adolescents published in English was searched between January 1980 and May 2017 using PubMed, MEDLINE, EMBASE, and Google Scholar research databases. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_557_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425769PMC
March 2019
1 Read

Nondihydropyridine Calcium Channel Blockers for the Treatment of Proteinuria: A Review of the Literature.

Ann Pharmacother 2019 Apr 9:1060028019843644. Epub 2019 Apr 9.

1 Auburn University Harrison School of Pharmacy, Huntsville, AL, USA.

Objective: To review the use of nondihydropyridine calcium channel blockers (non-DHP CCBs) for the treatment of proteinuria in diabetic and nondiabetic kidney disease.

Data Sources: A search using PubMed and MEDLINE, Scopus, and Google Scholar was performed from 1964 through February 2019 using the following search terms alone or in combination: verapamil, diltiazem, non-dihydropyridine calcium channel blocker, proteinuria, albuminuria, microalbuminuria, kidney disease, renal disease.

Study Selection And Data Extraction: All prospective English-language trials examining one or more non-DHP CCB for the treatment of proteinuria were evaluated. Read More

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http://dx.doi.org/10.1177/1060028019843644DOI Listing
April 2019
3 Reads

Open-Label Clinical Trials of Oral Pulse Dexamethasone for Adults with Idiopathic Nephrotic Syndrome.

Am J Nephrol 2019 Apr 9;49(5):377-385. Epub 2019 Apr 9.

Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland, USA,

Background: In adults with primary focal segmental glomerulosclerosis (FSGS), daily prednisone may induce complete remissions (CR) and partial remissions (PR), but relapses are frequent and adverse events are common.

Methods: We carried out 2 open-label, uncontrolled trials to explore the efficacy and tolerability of pulse oral dexamethasone as an alternative to daily prednisone. We enrolled adult patients with proteinuria > 3. Read More

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http://dx.doi.org/10.1159/000497064DOI Listing
April 2019
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A Case of Rheumatoid Arthritis Presenting with Renal Thrombotic Microangiopathy Probably due to a Combination of Chronic Tacrolimus Arteriolopathy and Severe Hypertension.

Case Rep Nephrol 2019 6;2019:3923190. Epub 2019 Mar 6.

Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

A 51-year-old woman with rheumatoid arthritis presented with mild hypertension 20 months after tacrolimus treatment and developing proteinuria 24 months after the treatment. Tacrolimus was discontinued 27 months after the treatment, followed by heavy proteinuria, accelerated hypertension, and deteriorating renal function without ocular fundus lesions as a clinical sign of malignant hypertension. Renal biopsy revealed malignant nephrosclerosis characterized by subacute and chronic thrombotic microangiopathy (TMA), involving small arteries, arterioles, and glomeruli. Read More

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http://dx.doi.org/10.1155/2019/3923190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431373PMC
March 2019
1 Read

Scleromyxedema (Arndt - Gottron Syndrome) Developing Under Tenofovir Treatment for Hepatitis B: Unique Presentation in a Bulgarian Patient!

Open Access Maced J Med Sci 2019 Mar 28;7(5):782-785. Epub 2019 Feb 28.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia, Bulgaria.

Background: Scleromyxedema, also referred to as the Arndt-Gottron (S-AG) syndrome or the systemic form of Lichen myxedematosus (LM), is a cutaneous mucinosis with a chronic course and high lethality from systemic involvement of other organs and systems. Interesting in several aspects is the association between scleromyxedema and viral hepatitis about: 1) hepatitis virus infection as a possible etiological factor for the development of scleromyxedema, 2) antiretroviral therapy for the treatment of hepatitis as a method of reversing scleromyxedema and 3) antiviral drugs as inducers of scleromyxedema.

Case Report: We present a 53-year old patient who for nine months had been on tenofovir disoproxil 245 mg (0-0-1) therapy for chronic hepatitis B. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2019.181
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http://dx.doi.org/10.3889/oamjms.2019.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447340PMC
March 2019
1 Read

Diagnostic role of renal biopsy in PLAR1-antibody-positive patients with nephrotic syndrome.

Mod Pathol 2019 Apr 8. Epub 2019 Apr 8.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Renal biopsy is the gold standard for diagnosis of membranous nephropathy. Circulating PLAR1 antibody found in 75% of patients with membranous nephropathy is very specific for the diagnosis of this disease. Therefore, the question arises whether PLAR1-antibody-positive patients still need a diagnostic renal biopsy. Read More

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http://dx.doi.org/10.1038/s41379-019-0267-zDOI Listing
April 2019
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Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

BMC Nephrol 2019 Apr 8;20(1):123. Epub 2019 Apr 8.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami, Ibaraki, 300-0395, Japan.

Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are frequently observed in glomerular lesions of thymoma patients, but ANCA-associated renal vasculitis is rare. Read More

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http://dx.doi.org/10.1186/s12882-019-1319-9DOI Listing
April 2019
1 Read

CD4/CD8 ratio improvement in HIV-1-infected patients receiving dual antiretroviral treatment.

Int J STD AIDS 2019 Apr 8:956462419834129. Epub 2019 Apr 8.

Department of Infectious Diseases, Ramón y Cajal Hospital, Madrid, Spain.

The CD4/CD8 ratio is an indirect marker of immune activation, immune senescence, and inflammation in HIV infection. We performed a prospective study of the CD4/CD8 ratio evolution in 245 virally-suppressed (median, 55 months) HIV-infected patients (29% females) who had switched to four dual antiretroviral regimens. At baseline, the median CD4/CD8 ratio was 0. Read More

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http://dx.doi.org/10.1177/0956462419834129DOI Listing
April 2019
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Clinical manifestations, immunological features and prognosis of Chinese pediatric systemic lupus erythematosus: A single-center study.

Int J Rheum Dis 2019 Apr 8. Epub 2019 Apr 8.

Department of Nephrology and Rheumatology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Aim: Since there are only a few reports on pediatric systemic lupus erythematosus (pSLE) in Chinese populations, therefore we retrospectively report the clinical and immunological features as well as renal outcome in Chinese pSLE.

Methods: Patients diagnosed with pSLE at Shanghai Children's Medical Center between 2001 and 2016 were evaluated and clinical data were retrospectively collected.

Results: A total of 102 pSLE patients were analyzed. Read More

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http://dx.doi.org/10.1111/1756-185X.13547DOI Listing
April 2019
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MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation.

Kidney Int 2019 Mar 5. Epub 2019 Mar 5.

Department of Nephrology, State Key Laboratory of Reproductive Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China. Electronic address:

Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs that were enriched in the mitochondrial fraction. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.028DOI Listing
March 2019
8.563 Impact Factor

PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.

J Cell Mol Med 2019 Apr 6. Epub 2019 Apr 6.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Diabetic nephropathy (DN) is a chronic inflammatory disease triggered by disordered metabolism. Recent studies suggested that protein tyrosine phosphatase non-receptor type 2 (PTPN2) could ameliorate metabolic disorders and suppress inflammatory responses. This study investigated PTPN2's role in modulating DN and the possible cellular mechanisms involved. Read More

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http://dx.doi.org/10.1111/jcmm.14304DOI Listing
April 2019
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Triglyceride-glucose index is a predictor of incident chronic kidney disease: a population-based longitudinal study.

Clin Exp Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii cho, Kamigyo-ku, Kyoto, 621-8585, Japan.

Background: Insulin resistance is one of the risks of chronic kidney disease (CKD). The triglyceride-glucose index (TyG index) has been suggested as a marker of moderate insulin resistance. We aimed to investigate the association between TyG index and incident CKD. Read More

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http://dx.doi.org/10.1007/s10157-019-01729-2DOI Listing
April 2019
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Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease.

Clin Exp Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Division of Nephrology, John H. Stroger, Jr. Hospital of Cook County, 1950 West Polk Street, Suites 5-56, Professional Building, Chicago, IL, 60612, USA.

Background: Previously we found that kidney tissue and urinary exosomes from patients of diabetic kidney disease showed high levels of ceruloplasmin (CP). Because CP is an acute-phase protein of kidney origin, it could be an early marker of many other kidney diseases. To investigate this hypothesis, we first measured urine exosomal and kidney expression of CP in non-diabetic chronic kidney disease (CKD) patients (membranous nephropathy, focal segmental glomerulosclerosis, lupus nephritis and IgA nephropathy) followed by a longitudinal study in rat passive Heymann nephritis (PHN), a model of human membranous nephropathy. Read More

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http://dx.doi.org/10.1007/s10157-019-01734-5DOI Listing
April 2019
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Role of anemia and proteinuria in the development of subsequent renal function deterioration in a general population with preserved glomerular filtration rate: a community-based cohort study.

J Nephrol 2019 Apr 6. Epub 2019 Apr 6.

The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.

Background: Risk factors for renal function deterioration in the general population are not fully understood. We aimed to clarify the determinants of estimated glomerular filtration rate (eGFR) decline using a community-based cohort.

Methods And Results: Among 3217 subjects who underwent repeated health check-ups, we excluded 478 subjects with eGFR ≤ 60 mL/min/1. Read More

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http://dx.doi.org/10.1007/s40620-019-00605-2DOI Listing

Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study.

Pediatr Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland.

Background: Optimal treatment of Henoch-Schönlein purpura nephritis (HSN) remains unclear. We evaluated outcome of pediatric HSN patients treated initially with either methylprednisolone (MP) or cyclosporine A (CyA) in Finland between 1996 and 2011.

Methods: Outcome of 62 HSN patients was evaluated by screening urine and blood samples (n = 51) or by collecting clinical parameters from medical charts until last follow-up visit (n = 11). Read More

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http://dx.doi.org/10.1007/s00467-019-04238-2DOI Listing
April 2019
2 Reads

Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands.

Endocrinol Diabetes Nutr 2019 Apr 4. Epub 2019 Apr 4.

Servicio de Nefrología, Hospital Universitario Insular, Las Palmas de Gran Canaria, España.

Introduction: Certain polymorphisms in the non-muscle myosin IIA (MYH9) and apolipoprotein L1 (APOL1) genes have been associated to chronic kidney disease (CKD) in different populations. This study examined the association between the MHY9 rs2032487 and APOL1 rs73885319 polymorphisms and advanced CKD related to type 2 diabetes mellitus (T2DM) in a population of Gran Canaria (Canary Islands, Spain).

Patients And Methods: Polymorphisms were genotyped in 152 patients with advanced CKD (estimated glomerular filtration rate [eGFR]<30mL/min/1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193003
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http://dx.doi.org/10.1016/j.endinu.2019.01.006DOI Listing
April 2019
3 Reads