59,473 results match your criteria Proteinuria


Amino acid status in dogs with protein-losing nephropathy.

J Vet Intern Med 2019 Feb 19. Epub 2019 Feb 19.

Center for Biostatistics, The Ohio State University, Columbus, Ohio.

Background: Proteinuria in dogs with kidney disease can contribute to protein-energy wasting and malnutrition. Little is known about amino acid (AA) status in dogs with protein-losing nephropathy (PLN).

Objectives: The purpose of our study was to further elucidate AA status in PLN dogs, with the hypothesis that PLN dogs would have altered AA status as compared to healthy dogs. Read More

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http://dx.doi.org/10.1111/jvim.15436DOI Listing
February 2019

Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy.

Exp Ther Med 2019 Mar 18;17(3):1825-1830. Epub 2018 Dec 18.

Department of Nephrology, Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

The present study aimed to explore the correlation between the dynamic serum levels of phospholipase A2 receptor (PLA2R), aldose reductase (AR) and superoxide dismutase 2(SOD2) antibodies with disease activity and treatment response in patients with idiopathic membranous nephropathy (IMN). The present study included 56 patients with IMN who were diagnosed through a renal biopsy and presenting with nephrotic syndrome. The patients were divided into two treatment groups: One treated with cyclophosphamide (CTX) and one with tacrolimus (FK506). Read More

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http://dx.doi.org/10.3892/etm.2018.7108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364219PMC

Studies on the Purification and Characterization of Human Urinary Plasminogen and Plasmin.

Thromb Haemost 1979 Jul 18;42(1):1536-1547. Epub 2019 Feb 18.

The Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

A new method is described for the preparation of highly purified human plasminogen and plasmin with specific activity of 32 CTA units per mg of protein. With this method, the purification of the urinary plasminogen + plasmin antigenic materials from patients with chronic glomerulonephritis, disseminated intravascular coagulation syndrome and severe toxemia of pregnancy was performed, and the resulting highly purified proenzyme and enzyme were analyzed by immunoelectrophoresis, separative agar electrophoresis, gel filtration and SDS-gel electrophoresis.Our findings indicated that urinary plasmin reflects more closely the extent of intraglomerular fibrinolysis, while urinary plasminogen reflects non-selective proteinuria in patients with chronic glomerulonephritis or severe toxemia of pregnancy. Read More

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http://dx.doi.org/10.1055/s-0038-1657056DOI Listing

Steroid therapy in children with IgA nephropathy.

Pediatr Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Department of Nephrology, Transplantation and Emergency, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France.

IgA nephropathy (IgAN) is one the most common primary glomerulonephritis in children and adolescents worldwide, with 20% of children developing end-stage kidney disease (ESKD) within 20 years of diagnosis. There is a need for treatment guidelines, especially for steroids in children with primary IgAN, since the STOP-IgA trial casts doubts on the use of steroids in adults with intermediate risk. Pediatricians are prone to prescribe steroids in addition to renin-angiotensin system blockade (RASB) when proteinuria is > 0. Read More

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http://dx.doi.org/10.1007/s00467-018-4189-7DOI Listing
February 2019

IgA nephropathy: is a new approach beyond proteinuria necessary?

Pediatr Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Nephrology Department, Hospital Universiatrio 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1007/s00467-019-4202-9DOI Listing
February 2019

A Novel Homozygous Truncating Mutation in Gene in a Chinese Uyghur Patient With Severe Phenotype Pierson Syndrome.

Front Med (Lausanne) 2019 4;6:12. Epub 2019 Feb 4.

Pediatric, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Pierson syndrome (OMIM 609049) is a rare autosomal recessive disorder characterized by congenital nephrotic syndrome and complex ocular abnormalities. Severe renal symptoms had be associated with truncating mutations. Few Chinese patients from diverse ethnic background had been evaluated and reported with this syndrome. Read More

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http://dx.doi.org/10.3389/fmed.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369156PMC
February 2019

Relationship Between Peripheral-Central Blood Pressure and Cardiac-Renal Damage in Kidney Transplant Recipients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):188-194

From the Department of Internal Medicine, Cukurova University Faculty of Medicine, Adana, Turkey.

Objectives: Hypertension is a common and important problem in kidney transplant recipients, directly affecting graft and patient survival. Here, we evaluated the relationship between renal-cardiac damage and peripheral and central aortic blood pressure levels in renal transplant recipients.

Materials And Methods: We measured peripheral blood pressure (office, daytime ambulatory, and central aortic) in 46 kidney transplant recipients. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P59DOI Listing
January 2019

Successful Treatment With Abatacept in Recurrent Focal Segmental Glomerulosclerosis After Kidney Transplant.

Exp Clin Transplant 2019 Jan;17(Suppl 1):178-180

From the Department of Adult Kidney and Pancreas Transplantation, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Primary focal segmental glomerulosclerosis recurrence occurs in 10% to 50% of recipients after kidney transplant and may affect both children and adults. Treatment after recurrence with plasma exchange and immunosuppression is quite variable and challenging, and those who do not respond usually progress to allograft failure. Podocyte injury and B7-1 expression and subsequently its blockade (abatacept) have been reported to be associated with complete remission of proteinuria in 4 patients with focal segmental glomerulosclerosis recurrence after kidney transplantation and in 1 patient with focal segmental glomerulosclerosis in native kidney. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P53DOI Listing
January 2019

Thymoglobulin-Resistant T-Cell-Mediated Acute Rejection in a Pregnant Renal Transplant Recipient: Case Report and Review of the Literature.

Exp Clin Transplant 2019 Jan;17(Suppl 1):159-163

From the Hamed Al-Essa Organ Transplant Center, Kuwait.

To avoid graft rejection during pregnancy, frequent monitoring of serum drug levels is recommended. Pregnancy induces hyperfiltration in transplanted kidneys, as in native kidneys; therefore, detection of rejection can be difficult when monitoring by serum creatinine. If rejection is suspected, ultrasonographguided graft biopsy can be done; once proven, it can be treated with pulse steroids, but data are scarce regarding other agents. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P38DOI Listing
January 2019

Onset of Hypertension in Living Kidney Donors After Donor Nephrectomy: Our 20 Years of Experience.

Exp Clin Transplant 2019 Jan;17(Suppl 1):156-158

From the Department of Nephrology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

Objectives: The development of hypertension can negatively affect cardiovascular and renal outcomes in renal kidney donors. Here, we retrospectively investigated the frequency and risk factors of hypertension development in healthy renal donors at our center.

Materials And Methods: Living donors of kidney transplants performed between January 1998 and December 2016 were evaluated. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P32DOI Listing
January 2019

Podocyte histone deacetylase activity regulates murine and human glomerular diseases.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Department of Internal Medicine, and.

We identified 2 genes, histone deacetylase 1 (HDAC1) and HDAC2, contributing to the pathogenesis of proteinuric kidney diseases, the leading cause of end-stage kidney disease. mRNA expression profiling from proteinuric mouse glomeruli was linked to Connectivity Map databases, identifying HDAC1 and HDAC2 with the differentially expressed gene set reversible by HDAC inhibitors. In numerous progressive glomerular disease models, treatment with valproic acid (a class I HDAC inhibitor) or SAHA (a pan-HDAC inhibitor) mitigated the degree of proteinuria and glomerulosclerosis, leading to a striking increase in survival. Read More

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http://dx.doi.org/10.1172/JCI124030DOI Listing
February 2019

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir With or Without Ribavirin in Patients With Kidney Disease.

Kidney Int Rep 2019 Feb 16;4(2):245-256. Epub 2018 Oct 16.

Mount Sinai Beth Israel, New York, New York, USA.

Introduction: Patients with hepatitis C virus (HCV) infection and chronic kidney disease (CKD) are a high-priority population for treatment.

Methods: We performed a pooled efficacy and safety analysis that included HCV genotype 1-infected patients with compensated liver disease and CKD stages 1 to 3 who received the all-oral 3-direct-acting antiviral regimen of ombitasvir, paritaprevir, ritonavir, and dasabuvir ± ribavirin (OBV/PTV/r + DSV ± RBV) in 11 phase 3 clinical trials. Sustained virologic response rates at posttreatment week 12 (SVR12) and treatment-related adverse events (AEs), serious AEs, and renal-associated AEs are reported. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365509PMC
February 2019

Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab.

Case Rep Nephrol 2019 15;2019:3614980. Epub 2019 Jan 15.

Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several "immune-mediated" adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3. Read More

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http://dx.doi.org/10.1155/2019/3614980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350541PMC
January 2019

Abnormal renovascular resistance in dogs with diabetes mellitus: correlation with glycemic status and proteinuria.

Iran J Vet Res 2018 ;19(4):304-309

Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, Madras Veterinary College, TANUVAS, Chennai-600007, India.

Present study was conducted with the objectives of determining the renal vascular resistance in dogs with diabetes mellitus and to study the correlation between the indices of renovascular resistance with glycemic status, systolic blood pressure (SBP) and proteinuria in dogs with diabetes mellitus. This study was conducted on seventeen diabetic dogs and ten apparently healthy dogs. Increased renal resistive index (RI) and pulsatility index (PI) were observed in diabetic dogs as compared to healthy dogs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361597PMC
January 2018

Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

Podocyte injury is the major cause of proteinuria in primary glomerular diseases. Oxidative stress has long been thought to play a role in triggering podocyte damage; however, the underlying mechanism remains poorly understood. Here we show that the Wnt/β-catenin pathway is involved in mediating oxidative stress-induced podocyte dysfunction. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.032DOI Listing
February 2019

Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

In type 2 cardiorenal syndrome, chronic heart failure is thought to cause or promote chronic kidney disease; however, the underlying mechanisms remain poorly understood. We investigated the role of Wnt signaling in heart and kidney injury in a mouse model of cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC). At 8 weeks after TAC, cardiac hypertrophy, inflammation, and fibrosis were prominent, and echocardiography confirmed impaired cardiac function. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.021DOI Listing
February 2019
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A Modern Primer on Light Chain Amyloidosis in 592 Patients With Mass Spectrometry-Verified Typing.

Mayo Clin Proc 2019 Feb 13. Epub 2019 Feb 13.

Division of Hematology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To describe the clinical and laboratory characteristics of patients with meticulously typed light chain (AL) amyloidosis.

Patients And Methods: Patients (N=592) with biopsy-proven, mass spectrometry-confirmed AL amyloidosis diagnosed from January 1, 2008, through August 31, 2015, were included.

Results: The median patient age at diagnosis was 63 years. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.08.006DOI Listing
February 2019

Implementing Reverse Phase Protein Array profiling as a sensitive method for the early pre-clinical detection of off-target toxicities associated with Sunitinib Malate.

Proteomics Clin Appl 2019 Feb 15:e1800159. Epub 2019 Feb 15.

RCSI Centre for Systems Medicine, Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

The tyrosine kinase inhibitor (TKI) sunitinib is a multi-targeted agent approved across multiple cancer indications. Nevertheless, since approval, data has emerged to describe a worrisome side effect profile including hypertension, hand-foot syndrome, fatigue, diarrhoea, mucositis, proteinuria and (rarely) congestive heart failure. It has been hypothesised that the observed multi-parameter toxicity profile is related to 'on-target' kinase inhibition in 'off-target' tissues. Read More

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http://dx.doi.org/10.1002/prca.201800159DOI Listing
February 2019
1 Read

Urinalysis and determination of the urine protein-to-creatinine ratio reference interval in healthy cows.

J Vet Intern Med 2019 Feb 15. Epub 2019 Feb 15.

CREFRE, Université de Toulouse, INSERM, UPS, ENVT, Toulouse, France.

Background: There are no reference intervals for urinalysis in cattle.

Hypothesis/objectives: Characterize the urine of healthy cows, establish urine protein-to-creatinine ratio (UPC) reference intervals, and test possible differences among dairy and beef cattle, age groups, or stage of lactation.

Animals: Seventy-seven dairy and 74 beef 2. Read More

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http://dx.doi.org/10.1111/jvim.15452DOI Listing
February 2019
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A Phase II Trial of Ziv-Aflibercept in Patients With Advanced Pancreatic Neuroendocrine Tumors.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

From the Departments of Gastrointestinal Medical Oncology.

Objectives: Therapies for patients with advanced well-differentiated pancreatic neuroendocrine tumors (pNETs) are insufficient, with patients succumbing to disease despite recent treatment advances. Ziv-aflibercept is a fusion protein of portions of the vascular endothelial growth factor (VEGF) receptors 1 and 2, fused to the Fc portion of immunoglobulin G1, forming a VEGF trap. Perfusion computed tomography (CT) has previously defined hyperperfused neuroendocrine tumors, potentially predicting antiangiogenic benefit. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001258DOI Listing
February 2019
1 Read

Outcome of posterior urethral valve in 64 children. Single center experience of 22 years.

Minerva Urol Nefrol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatric Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turchia.

Background: Posterior urethral valve (PUV) is the most serious form of congenital anomalies of kidney and urinary tract (CAKUT) in boys with significant risk of progression to chronic kidney disease (CKD). We present our long term results in children with PUV.

Methods: Retrospective chart review of 113 children with PUV followed within the years of 1996-2018 was performed. Read More

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http://dx.doi.org/10.23736/S0393-2249.19.03272-7DOI Listing
February 2019
2 Reads
0.700 Impact Factor

Upregulated expression of STAT3/IL-17 in patients with systemic lupus erythematosus.

Clin Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Section of Rheumatology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

Elevated IL-17 levels with higher Th17 numbers are identified in systemic lupus erythematosus (SLE). STAT3 signaling plays a crucial role in the Th17 generation, and SOCS3 negatively regulates their formation. We investigated IL-17, STAT3, and SOCS3 expression, and analyzed their correlations to elucidate the regulatory mechanisms of IL-17 production in SLE. Read More

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http://dx.doi.org/10.1007/s10067-019-04467-8DOI Listing
February 2019
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Renal Dysfunction in Patients With Nonalcoholic Fatty Liver Disease is Related to the Presence of Diabetes Mellitus and Severity of Liver Disease.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):22-28. Epub 2017 Dec 30.

Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.

Background And Aims: There is sparse data on the prevalence of renal dysfunction in patients with nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the presence of renal dysfunction in patients with NAFLD and correlate it with the severity of liver disease.

Methods: One hundred nonalcoholic patients with ultrasound showing hepatic steatosis were enrolled into the study after exclusion of other causes. Read More

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http://dx.doi.org/10.1016/j.jceh.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363960PMC
December 2017
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Occurrence of Diabetic Nephropathy After Renal Transplantation Despite Intensive Glycemic Control: An Observational Cohort Study.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Objective: The kinetics and risk factors of diabetic nephropathy after kidney transplantation remain unclear. This study investigated the posttransplant occurrence of diabetic nephropathy and the contribution of posttransplant glycemic control.

Research Design And Methods: We performed a single-center prospective cohort study of 953 renal allograft recipients and 3,458 protocol-specified renal allograft biopsy specimens up to 5 years after transplantation. Read More

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http://dx.doi.org/10.2337/dc18-1936DOI Listing
February 2019
1 Read

Repository Corticotropin Versus Glucocorticoid for Nephrotic Syndrome: When Will We See the Evidence?

Am J Kidney Dis 2019 Feb 11. Epub 2019 Feb 11.

VA Portland Health Care System, Research Service, Portland, OR; Division of Nephrology and Hypertension, Department of Medicine, Oregon Health & Science University, Portland, OR. Electronic address:

Despite little evidence supporting its superiority to glucocorticoid therapy, use and expenditures for repository corticotropin (rACTH) injection (H.P. Acthar Gel; Mallinckrodt) have increased dramatically in the last 5 years, particularly among a small number of nephrologists, rheumatologists, and neurologists. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193000
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http://dx.doi.org/10.1053/j.ajkd.2018.12.025DOI Listing
February 2019
4 Reads

Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.

BMC Nephrol 2019 Feb 14;20(1):53. Epub 2019 Feb 14.

Department of Pathology, Division of Renal and Transplant Pathology, Ohio State University Wexner Medical Center, M018 Starling-Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA.

Background: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1239-8DOI Listing
February 2019
2 Reads

Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14557

Department of Nephrology.

Rationale: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) antibody disease are both rare autoimmune diseases. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common causes of plasma cell dyscrasias (PCD). The three entities can cause renal lesions via different mechanisms and, however, they have not been reported in a single patient with renal lesion. Read More

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http://dx.doi.org/10.1097/MD.0000000000014557DOI Listing
February 2019
1 Read

Antibodies to M-type phospholipase A2 receptor (PLAR) in membranous lupus nephritis.

Lupus 2019 Feb 13:961203319828521. Epub 2019 Feb 13.

1 Department of Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitari Vall d'Hebrón, Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Antibodies to M-type phospholipase A2 receptor (a-PLAR) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLAR antibodies in a large cohort of patients with lupus nephritis.

Methods: a-PLAR antibodies were measured by ELISA in serum from patients with systemic lupus erythematosus ( n = 190), of whom 37 had a biopsy-proven MLN. Read More

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http://dx.doi.org/10.1177/0961203319828521DOI Listing
February 2019
6 Reads

Diabetes control could through platelet-to-lymphocyte ratio in hemograms.

Rev Assoc Med Bras (1992) 2019 Jan;65(1):38-42

Abant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.

Objective: Association between type 2 diabetes mellitus and inflammation is well-established. We aimed to study platelet-to-lymphocyte ratio (PLR), a novel inflammatory index derived from hemogram, in diabetic patients in comparison to those in healthy volunteers.

Methods: Medical data of type 2 diabetics that showed up in general outpatient medical clinics of our institution between February 2017 and August 2017 were recorded and analyzed. Read More

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http://dx.doi.org/10.1590/1806-9282.65.1.38DOI Listing
January 2019
1 Read

miR-939-5p decreases the enrichment of RNA polymerase II in the promoter region of CD2AP involved in nephrotic syndrome.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.

The expression changes of CD2-associated protein (CD2AP) can lead to kidney diseases with proteinuria, including nephrotic syndrome (NS). A recent study reported that miRNAs may be important transcriptional regulators. In this study, we found increased expression of miR-939-5p and decreased expression of CD2AP in the peripheral blood of patients with NS. Read More

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http://dx.doi.org/10.1002/jcb.28413DOI Listing
February 2019
1 Read
3.263 Impact Factor

Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies.

Target Oncol 2019 Feb 11. Epub 2019 Feb 11.

Division of Medical Oncology, Princess Margaret Cancer Centre, 610 University Avenue, Suite 5-718, Toronto, ON, M5G 2M9, Canada.

Background: Overexpression/activation of focal adhesion kinase (FAK) in human malignancies has led to its evaluation as a therapeutic target. We report the first-in-human phase I study of BI 853520, a novel, potent, highly selective FAK inhibitor.

Objective: Our objectives were to identify the maximum tolerated dose (MTD), and to evaluate safety, pharmacokinetics (PK), pharmacodynamics (PD), biomarker expression, and preliminary activity. Read More

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http://dx.doi.org/10.1007/s11523-018-00617-1DOI Listing
February 2019
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Comparison of measurements of anti-PLA2R antibodies in Japanese patients with membranous nephropathy using in-house and commercial ELISA.

Clin Exp Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Department of Life Science, Akita University Graduate School of Engineering Science, Akita City, Japan.

Background: The prevalence of antibodies against M-type anti-phospholipase A2 receptor (PLA2R) was reported to be ~ 70-80% in early studies on idiopathic membranous nephropathy (iMN) cohorts from Western countries, China, and Korea, and ~ 50% in recent studies on two Japanese iMN cohorts.

Methods: We developed an in-house enzyme-linked immunosorbent assay (ELISA) for the detection of anti-PLA2R antibodies, and examined sera from 217 patients with iMN, 22 patients with secondary MN (sMN), and 50 healthy individuals. All patients and healthy individuals were Japanese. Read More

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http://dx.doi.org/10.1007/s10157-019-01712-xDOI Listing
February 2019
1 Read

Use of Intravenous Immunoglobulin Therapy at Unconventional Doses in Refractory Fulminant Systemic Lupus Erythematosus.

Eur J Case Rep Intern Med 2018 27;5(9):000934. Epub 2018 Sep 27.

Rare Diseases and Periodic Fevers Research Centre, Department of Internal Medicine, Agostino Gemelli University Hospital Foundation, Catholic University of the Sacred Heart, Rome, Italy.

The use of human intravenous immunoglobulins (IVIg) in systemic lupus erythematosus (SLE) currently relies on evidence from small case series and is mainly regarded as an off-label strategy in cases that are refractory to conventional therapies or poorly controlled with high doses of corticosteroids. Standard dosage regimens typically entail the administration of a total amount of 2 g/kg of IVIg divided into five consecutive days in order to minimize the risk of severe adverse events. We herein describe the case of a 28-year-old woman with a known history of antiphospholipid syndrome (APS) who was admitted to our hospital following fulminant onset of SLE in spite of ongoing immunosuppressive therapy. Read More

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http://dx.doi.org/10.12890/2018_000934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346821PMC
September 2018
1 Read

Refractory lupus nephritis: a survey.

Lupus 2019 Feb 12:961203319828516. Epub 2019 Feb 12.

Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Munich, Germany.

'Refractory lupus nephritis' is a frequently used term but poorly defined. We conducted a survey among nephrologists and rheumatologists to spot the diversity of perceptions of this term and to better understand the clinical practice related to 'refractory lupus nephritis'. A total of 145 questionnaires completed by lupus nephritis experts were available for analysis, of which 52% were nephrologists, 34% rheumatologists, and 13% internists. Read More

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http://journals.sagepub.com/doi/10.1177/0961203319828516
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http://dx.doi.org/10.1177/0961203319828516DOI Listing
February 2019
2 Reads

Nutritional Management for Chronic Kidney Disease Patients who Undergo Bariatric Surgery: A Narrative Review.

Adv Nutr 2019 Jan;10(1):122-132

Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Bariatric surgery (BS) may be effective for chronic kidney disease (CKD) patients by reducing microalbuminuria and proteinuria, and by facilitating their meeting inclusion criteria for kidney transplantation. However, nutritional management for this population is complex and specific guidelines are scarce. A literature search was performed to create dietetic practice for these patients based on the most recent evidence. Read More

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http://dx.doi.org/10.1093/advances/nmy112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370259PMC
January 2019
1 Read
4.891 Impact Factor

Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain.

PLoS One 2019 12;14(2):e0211903. Epub 2019 Feb 12.

Department of Pharmacology & Toxicology, Augusta University, Augusta, GA, United States of America.

The link between blood pressure (BP) and cerebral function is well established. However, it is not clear whether a common mechanism could underlie the relationship between elevated BP and cognitive deficits. The expression of calcyon, a gene abundant in catecholaminergic and hypothalamic nuclei along with other forebrain regions, is increased in the brain of the spontaneously hypertensive rat (SHR) which is a widely accepted animal model of essential hypertension and attention deficit hyperactivity disorder (ADHD). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211903PLOS
February 2019
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Response to Treatment and Long-Term Outcomes in Kidney Transplant Recipients with Acute T Cell-Mediated Rejection.

Am J Transplant 2019 Feb 12. Epub 2019 Feb 12.

Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, Paris, France.

The recent recognition of complex and chronic phenotypes of T cell-mediated rejection (TCMR) has fostered the need to better evaluate the response of acute TCMR - a condition previously considered to lack relevant consequences for allograft survival - to the standard of care. In a prospective cohort of kidney recipients (n=256) with biopsy-proven acute TCMR receiving corticosteroids, we investigated clinical, histological and immunological phenotypes at the time of acute TCMR diagnosis and 3 months posttreatment. Independent posttreatment determinants of allograft loss included the glomerular filtration rate (GFR) (HR=0. Read More

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http://dx.doi.org/10.1111/ajt.15299DOI Listing
February 2019
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Recurrent proliferative glomerulonephritis with monoclonal immunoglobulin deposits in kidney allografts treated with anti-cd20 antibodies.

Transplantation 2019 Feb 4. Epub 2019 Feb 4.

Division of Nephrology and Hypertension, Department of Internal Medicine, William von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic, Rochester, MN, USA.

Background: proliferative glomerulonephritis with monoclonal immunoglobulin (Ig) deposits (PGNMID) is a distinct form of glomerulonephritis (GN) that often recurs after kidney transplantation causing severe graft injury and often failure.

Methods: we describe post-transplant outcomes and response to therapy in 20 recipients with PGNMID. Evidence of PGNMID recurrence or lack thereof was determined by protocol and clinical biopsies. Read More

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http://dx.doi.org/10.1097/TP.0000000000002577DOI Listing
February 2019
3 Reads

Non-immune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist.

J Clin Invest 2019 Feb 12. Epub 2019 Feb 12.

Soluble urokinase receptor (suPAR) is a circulatory molecule that activates αvβ3 integrin on podocytes, causes foot process effacement, and contributes to proteinuric kidney disease. While active integrin can be targeted by antibodies and small molecules, endogenous inhibitors haven't been discovered yet. Here we report a novel, renoprotective role for inducible costimulator (ICOS) ligand (ICOSL) in early kidney disease through its selective binding to podocyte αvβ3 integrin. Read More

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http://dx.doi.org/10.1172/JCI123386DOI Listing
February 2019
2 Reads

Nephrotic range proteinuria and acute heart failure.

Intern Emerg Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Surgical and Medical Sciences, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1007/s11739-019-02029-zDOI Listing
February 2019
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Collapsing glomerulopathy in a child with LCHAD deficiency: a rare association.

CEN Case Rep 2019 Feb 12. Epub 2019 Feb 12.

Department of Paediatrics, Sheikh Khalifa Medical City, P O Box 51900, Abu Dhabi, United Arab Emirates.

Metabolic disorders, although rare, can involve multiple organ systems and have a varied presentation. Renal involvement has been reported in several metabolic disorders in the pediatric age group. We report a rare metabolic disorder, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, in a child who developed steroid-resistant nephrotic syndrome at the age of 5 years. Read More

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http://dx.doi.org/10.1007/s13730-019-00387-3DOI Listing
February 2019
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Early decrease in the podocalyxin to synaptopodin ratio in urinary Fabry podocytes.

Clin Kidney J 2019 Feb 20;12(1):53-60. Epub 2018 Jul 20.

IFIBIO Houssay, CONICET, Physiopathology, Pharmacy and Biochemistry Faculty, Universidad de Buenos Aires, Buenos Aires, Argentina.

Background: In Fabry nephropathy, podocyturia is an early event that may lead to glomerulosclerosis and chronic kidney disease. The glycocalyx is a potential podocyte damaged compartment in glomerulopathies. We investigated glycocalyx podocalyxin in urinary detached podocytes compared with cytoplasmic synaptopodin. Read More

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http://dx.doi.org/10.1093/ckj/sfy053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366138PMC
February 2019
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Antiphospholipase 2 receptor antibody levels to predict complete spontaneous remission in primary membranous nephropathy.

Clin Kidney J 2019 Feb 9;12(1):36-41. Epub 2018 Mar 9.

Servicio de Nefrología y Trasplante Renal, Hospital Clínic, Departamento de Medicina, Universidad de Barcelona, Institut d' Invesigacions biomèdiques Agust Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: M-type phospholipase A2 receptor (APLA2R) is considered the major antigen involved in the pathogenesis of adult primary membranous nephropathy (MN), which is the leading cause of non-diabetic nephrotic syndrome. Antibodies to this antigen have been proved to be an excellent biomarker of disease activity in primary MN. In fact, preliminary data suggest that the higher the antibody level the more proteinuria, and that a decrease in antibody level precedes the remission of proteinuria, but more solid evidence is needed. Read More

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http://dx.doi.org/10.1093/ckj/sfy005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366127PMC
February 2019
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Anti-phospholipase A2 receptor antibody and spontaneous remission in membranous nephropathy.

Clin Kidney J 2019 Feb 3;12(1):33-35. Epub 2018 Oct 3.

Nephrology Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in native kidney biopsies from adults. In 2009, antibodies to the M-type receptor of phospholipase A2 (anti-PLA2R) were identified in idiopathic MN patients, both within the kidney and in the circulation. The clinical course of idiopathic MN is variable and ranges from spontaneous remission to end-stage renal disease. Read More

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https://academic.oup.com/ckj/article/12/1/33/5114409
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http://dx.doi.org/10.1093/ckj/sfy079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366130PMC
February 2019
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Three patients with injection of intravitreal vascular endothelial growth factor inhibitors and subsequent exacerbation of chronic proteinuria and hypertension.

Clin Kidney J 2019 Feb 27;12(1):92-100. Epub 2018 Jul 27.

Retinal Disorders and Ophthalmic Genetics, Department of Ophthalmology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.

Vascular endothelial growth factor (VEGF) receptor inhibition is a commonly used tool to prevent vascular proliferation in tumors and retinal diseases. The antiangiogenic effects of these drugs have made them potent adjunct therapies when given systemically for malignancies. They are also useful tools to ameliorate diminishing eyesight in retinopathy. Read More

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http://dx.doi.org/10.1093/ckj/sfy060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366143PMC
February 2019
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Renal toxicities associated with pembrolizumab.

Clin Kidney J 2019 Feb 9;12(1):81-88. Epub 2018 Nov 9.

Department of Pathology, Pitie-Salpetriere Hospital, Paris, France.

Objective: Expanded clinical experience with patients treated by pembrolizumab has accumulated. However, renal toxicities associated with this anti-programmed cell death 1 agent are poorly described because kidney histology is rarely sought. As a nephrology referral centre, we aimed to describe the clinic-biological and histopathological characteristics of pembrolizumab-related nephropathy and its response to treatment. Read More

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http://dx.doi.org/10.1093/ckj/sfy100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366307PMC
February 2019
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Identification of a Novel Variant in Compound-Heterozygous State in a Patient With Alport Syndrome and Histological Findings Similar to Focal Segmental Glomerulosclerosis (FSGS).

Front Genet 2018 28;9:748. Epub 2019 Jan 28.

Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Alport syndrome (AS) is a rare and inherited renal disorder with an autosomal recessive mode of inheritance. AS patients usually manifest with hematuria and progressive renal disorder also occasionally accompanied by hearing loss and ophthalmic disease. Germline variants in collagen type IV α-4 () gene lead to autosomal recessive Alport syndrome. Read More

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http://dx.doi.org/10.3389/fgene.2018.00748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360158PMC
January 2019
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Expectant or outpatient management of preeclampsia before 34 weeks: safe for mother but associated with increased stillbirth risk.

J Hum Hypertens 2019 Feb 11. Epub 2019 Feb 11.

The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China.

Today the only effective "treatment" for preeclampsia is to deliver at the optimal time for both maternal and foetal well-being. Studies reported that severe preeclampsia can benefit from the expectant management including mild preeclampsia between 34 and 37 weeks. However it is unclear whether mild preeclampsia before 34 weeks also benefits from the expectant management. Read More

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http://dx.doi.org/10.1038/s41371-019-0175-1DOI Listing
February 2019
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Recruitment of CXCR3 T cells into injured tissues in adult IgA vasculitis patients correlates with disease activity.

J Autoimmun 2019 Feb 8. Epub 2019 Feb 8.

Paris Descartes University, Cochin Institute, CNRS UMR8104, INSERM U1016, Paris, France. Electronic address:

Objectives: Adult immunoglobulin A vasculitis (IgAV) is an immune complex small vessel vasculitis. So far, the involvement of T cells in this pathology has been poorly studied. The aim of this study was to analyze T-cell homeostasis as well as cytokine and chemokine concentrations in the blood and tissues of IgAV patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183065
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http://dx.doi.org/10.1016/j.jaut.2019.01.012DOI Listing
February 2019
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Predictors of Renal Dysfunction in Adults with Childhood Vesicoureteral Reflux after Long-Term Follow-Up.

Open Access Maced J Med Sci 2019 Jan 14;7(1):107-113. Epub 2019 Jan 14.

University Clinic of Cardiology, Medical School, University Ss. Cyril and Methodius of Skopje, Skopje, Republic of Macedonia.

Background: Triad of childhood vesicoureteral reflux (VUR), urinary infection (UTI) and renal scarring might initiate potentially serious consequences that lead to renal dysfunction manifested at the second or third decade of life.

Aim: To identify the risk factors predictive for renal dysfunction in adults with primary VUR after long-term follow-up.

Methods: We evaluated the records of 101 children (94. Read More

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http://dx.doi.org/10.3889/oamjms.2019.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352487PMC
January 2019
1 Read