9,179 results match your criteria Protein-Energy Malnutrition


Inverse J-shaped relation between coronary arterial calcium density and mortality in advanced chronic kidney disease.

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Campus Flemingsberg, Stockholm, Sweden.

Background: The coronary artery calcium (CAC) score from cardiac computed tomography (CT) is a composite of CAC volume and CAC density. In the general population, CAC volume is positively and CAC density inversely associated with cardiovascular disease (CVD) events, implying that decreased CAC density reflects atherosclerotic plaque instability. We analysed associations of CAC indices with mortality risk in patients with end-stage renal disease [chronic kidney disease Stage 5 (CKD5)]. Read More

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December 2018

Malaria and Malnutrition: Kwashiorkor Associated with Low Levels of Parasitaemia.

Malar Res Treat 2018 27;2018:7153173. Epub 2018 Sep 27.

Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway.

Background: The relationship between protein energy malnutrition (PEM) and malaria is controversial. While most studies demonstrate that PEM is associated with greater malaria morbidity, some indicate that PEM may in fact have a protective effect. PEM is differentiated into three subgroups: kwashiorkor (marked protein deficiency), marasmus (calorie deficiency), and kwashiorkor/marasmus. Read More

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September 2018

Protein-energy wasting and asymmetric dimethylarginine in peritoneal dialysis patients.

Acta Biochim Pol 2018 Dec 3. Epub 2018 Dec 3.

Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdańsk, Poland.

Cardiovascular (CVS) morbidity and mortality in the peritoneal dialysis patients (PD) is 10-30-fold higher than in the general population. A relatively low level of adiponectin and a higher level of leptin are important predictors of vascular complications as well as CVS events in PD patients. The asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is an important risk factor of CVS morbidity and mortality. Read More

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December 2018
4 Reads

Malnutrition in older adults: screening and determinants.

Proc Nutr Soc 2018 Dec 3:1-8. Epub 2018 Dec 3.

UCD Institute of Food and Health, University College Dublin,Dublin,Republic of Ireland.

Older adults are at risk of protein-energy malnutrition (PEM). PEM detrimentally impacts on health, cognitive and physical functioning and quality of life. Given these negative health outcomes in the context of an ageing global population, the Healthy Diet for a Healthy Life Joint Programming Initiative Malnutrition in the Elderly (MaNuEL) sought to create a knowledge hub on malnutrition in older adults. Read More

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December 2018

Reoptimized UNRES Potential for Protein Model Quality Assessment.

Genes (Basel) 2018 Dec 3;9(12). Epub 2018 Dec 3.

Battelle Center for Mathematical Medicine, Nationwide Children's Hospital, Columbus, OH 43215, USA.

Ranking protein structure models is an elusive problem in bioinformatics. These models are evaluated on both the degree of similarity to the native structure and the folding pathway. Here, we simulated the use of the coarse-grained UNited RESidue (UNRES) force field as a tool to choose the best protein structure models for a given protein sequence among a pool of candidate models, using server data from the CASP11 experiment. Read More

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December 2018

Complementary Biomarker Assessment of Components Absorbed from Diet and Creatinine Excretion Rate Reflecting Muscle Mass in Dialysis Patients.

Nutrients 2018 Nov 26;10(12). Epub 2018 Nov 26.

Department of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

To prevent protein energy malnutrition (PEM) and accumulation of waste products, dialysis patients require diet adjustments. Dietary intake assessed by self-reported intakes often provides biased information and standard 24-h urinary excretion is inapplicable in dialysis patients. We aimed to assess dietary intake via a complementary, less biased biomarker method, and to compare this to dietary diaries. Read More

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November 2018

The impact of a nutritional intervention based on egg white for phosphorus control in hemodialyis patients.

Nutr Metab Cardiovasc Dis 2018 Sep 28. Epub 2018 Sep 28.

Department of Neuroscience, Reproductive Sciences and Dentistry, Division of Pharmacology, Federico II University of Naples, Italy; Federico II University Hospital, Naples, Italy.

Background And Aims: Here we describe a dietary intervention for hyperphosphatemia in dialysis patients based on the partial replacement of meat and fish, which are one of the main sources of alimentary phosphorous, with egg white, a virtually phosphorous-free protein source. This intervention aims to reduce phosphorous intake without causing protein wasting.

Patients And Methods: As many as 23 hyperphosphatemic patients (15 male and 8 female, mean age 53. Read More

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September 2018
3 Reads

Using a tablet application about nutrition in home care-Experiences and perspectives of healthcare professionals.

Health Soc Care Community 2018 Nov 19. Epub 2018 Nov 19.

Faculty of Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway.

Undernutrition is an extensive problem among patients in community care services. The literature identifies several barriers that hinder health professionals in identifying nutritional problems and providing nutrition interventions. We developed Appetitus, a tablet application (app) focused on nutrition for older adults. Read More

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November 2018
3 Reads

Association between malnutrition-inflammation score and risk of subsequent self-reported bone fractures in prevalent kidney transplant recipients.

Osteoporos Int 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine, Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.

Chronic inflammation and protein energy wasting (PEW) syndrome are common in kidney transplant recipients (KTR). The presence of inflammation and PEW syndrome can directly affect bone resorption and bone formation, leading to bone loss and fractures. We showed PEW is independently associated with new clinically detected bone fractures in prevalent KTR. Read More

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November 2018
6 Reads
4.169 Impact Factor

Bioelectrical Impedance Analysis-Derived Phase Angle Predicts Protein-Energy Wasting in Maintenance Hemodialysis Patients.

J Ren Nutr 2018 Nov 13. Epub 2018 Nov 13.

Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China.

Objective(s): To explore the validity of using bioelectrical impedance analysis (BIA)-derived 50 kHz phase angle (PhA) in predicting protein-energy wasting (PEW) in Chinese maintenance hemodialysis (MHD) patients.

Design And Methods: The design was a cross-sectional study. A total of 173 of MHD patients and 173 healthy adults were enrolled in the study. Read More

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November 2018
2 Reads

Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations.

PLoS One 2018 16;13(11):e0207234. Epub 2018 Nov 16.

Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Science, Jilin University, Changchun, China.

Adenosine deaminase (ADA) catalyzes the deamination of adenosine, which is important in purine metabolism. ADA is ubiquitous to almost all human tissues, and ADA abnormalities have been reported in various diseases, including rheumatoid arthritis. ADA can be divided into two conformations based on the inhibitor that it binds to: open and closed forms. Read More

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November 2018
4 Reads

[Association of low serum parathyroid hormone with protein-energy wasting in maintenance hemodialysis patients].

Zhonghua Yi Xue Za Zhi 2018 Nov;98(42):3401-3405

Renal Division, Department of Medicine, Guizhou Provincial People's Hospital, Guiyang 550002, China.

To examine the relationship between low serum parathyroid hormone (PTH) and protein-energy wasting (PEW) in patients who underwent maintenance hemodialysis (MHD) treatment. A cross-sectional study was conducted in MHD patients between June 2015 and August 2017 in 11 MHD centers from Guizhou province. Body composition and physical parameters were measured, clinical data and other related laboratory values were collected according to the medical record system. Read More

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November 2018
2 Reads

Are Dietitians Documenting Malnutrition Based on Subjective Global Assessment Category?

Can J Diet Pract Res 2018 11 15:1-4. Epub 2018 Nov 15.

a Clinical Nutrition, Fraser Health, Surrey, BC.

Purpose: This study reports on dietitian use of the Nutrition Care Process Terminology (NCPT) diagnosis of malnutrition based on Subjective Global Assessment (SGA).

Methods: Nutrition assessment reports for adults in medical, surgical, and cardiac units in 13 Canadian hospitals were retrospectively examined for a 6-week period in 2014. Reports with a SGA and NCPT diagnosis were included regardless of why the patient was seen by the dietitian. Read More

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November 2018
3 Reads

Evaluating hemodialysis patient's nutritional status: Body Mass Index or Body Cell Mass Index?

Nephrology (Carlton) 2018 Nov 9. Epub 2018 Nov 9.

Nephrocare, Portugal.

Objective: Evaluate which of two combinations of parameters based on ISRNM recommendations could better identify patients with Protein Energy Wasting (PEW) and to compare the relationship of these two combinations with other clinical and body composition parameters.

Design And Methods: This was a multicenter longitudinal study with 24 months of follow-up. The PEW patients were characterized by: Group A (G ) - normalized Protein Catabolic Rate (nPCR) < 1. Read More

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November 2018

Feeding cluster preferences in four genera of Lories and Lorikeets (Loriinae) that should be considered in the diet of nectarivorous psittacine species in captivity.

J Anim Physiol Anim Nutr (Berl) 2018 Nov 8. Epub 2018 Nov 8.

Conservation, Research and Veterinary Services, Wildlife Reserves Singapore, Singapore City, Singapore.

Lories and lorikeets are popular birds in the pet bird trade, captured from the wild and exported worldwide. Their captive propagation has not been so successful for many species due to health issues, low breeding success and reduced longevity. As a result, uptake from the wild is currently the only way to meet the market's demand. Read More

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November 2018
5 Reads

Iberian pig adaptation to acorn consumption: I. Net portal appearance of metabolites.

PeerJ 2018 31;6:e5861. Epub 2018 Oct 31.

Department of Physiology and Biochemistry of Animal Nutrition, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain.

Most valuable cured products from Iberian pigs come from pure bred animals raised for a final grazing-fattening period where pigs eat mainly acorns, a low protein energy rich fruit. This is a nutritional challenge for animals fed equilibrated diets from weaning. The aim of the study was to determine net portal appearance (NPA) of metabolites in gilts fed acorns and evaluate adaptational changes after one week of feeding. Read More

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October 2018

Lysozyme-rich milk mitigates effects of malnutrition in a pig model of malnutrition and infection.

Br J Nutr 2018 Nov;120(10):1131-1148

1Department of Animal Science,University of California,One Shields Avenue,Davis,CA 95616,USA.

Malnutrition remains a leading contributor to the morbidity and mortality of children under the age of 5 years and can weaken the immune system and increase the severity of concurrent infections. Livestock milk with the protective properties of human milk is a potential therapeutic to modulate intestinal microbiota and improve outcomes. The aim of this study was to develop an infection model of childhood malnutrition in the pig to investigate the clinical, intestinal and microbiota changes associated with malnutrition and enterotoxigenic Escherichia coli (ETEC) infection and to test the ability of goat milk and milk from genetically engineered goats expressing the antimicrobial human lysozyme (hLZ) milk to mitigate these effects. Read More

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November 2018
6 Reads

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project.

Ageing Res Rev 2018 Nov 2;49:27-48. Epub 2018 Nov 2.

Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.

Introduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts.

Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Read More

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November 2018
7 Reads

25 hydroxyvitamin D and nutritional parameters correlation in adults with stage 4 chronic kidney disease.

Clin Nutr ESPEN 2018 Dec 10;28:80-87. Epub 2018 Oct 10.

Department of Nephrology, Hospital General de México, Dr. Eduardo Liceaga Mexico, Mexico. Electronic address:

Background And Aims: Serum concentrations of 25-hydroxyvitamin D (abbreviated "25(OH)D") and parameters of nutritional status both decline as chronic kidney disease (CKD) progresses. The objective of this study was to measure and correlate 25(OH)D concentrations with alterations in the nutritional status of adult patients with stage 4 CKD.

Methods: The study was cross-sectional, included patients with stage 4 CKD (CKD-Epi between 15 and 30 ml/min/1. Read More

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December 2018

Poor agreement between indirect calorimetry and predictive formula of rest energy expenditure in pre-dialytic and dialytic chronic kidney disease.

Clin Nutr ESPEN 2018 Dec 23;28:136-140. Epub 2018 Sep 23.

Botucatu School of Medicine University Hospital, Av. Prof. Mário Rubens Guimarães Montenegro, s/n, UNESP - Botucatu18618687, Botucatu, Brazil.

Background/aims: Protein-energy wasting (PEW) is common in the end-stage of chronic kidney disease (CKD) and can be caused by factors related to poor dietary intake and changes in energy expenditure. Indirect calorimetry (IC) is the gold standard method to measure resting energy expenditure (REE), however, it is not much available and it is common to use predictive formulas of REE in clinical practice. This study compared the values of REE measured by IC to those estimated by Harris & Benedict formula, the most one used in clinical practice in Brazil. Read More

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December 2018

Influence of Sourdough Fermentation on Amino Acids Composition, Phenolic Profile, and Antioxidant Properties of Sorghum Biscuits.

Prev Nutr Food Sci 2018 Sep 30;23(3):220-227. Epub 2018 Sep 30.

Department of Food Science and Technology, The Federal University of Technology, Akure 340001, Nigeria.

Biscuits were produced from sorghum with and without the addition of sourdough. The influence of sourdough fermentation on the amino acids composition, phenolic profile, and antioxidant properties of the biscuits were evaluated. Phenolic compounds of the biscuits were identified and quantified using gas chromatography/mass spectrometer. Read More

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September 2018
2 Reads

Effect of soybean ( (L.) Merr.) flour inclusion on the nutritional properties and consumer preference of fritters for improved household nutrition.

Food Sci Nutr 2018 Oct 13;6(7):1811-1816. Epub 2018 Aug 13.

Food and Nutrition Sciences Laboratory International Institute of Tropical Agriculture (IITA) Ibadan Nigeria.

Diets in populations of most developing countries are often deficient in protein, carbohydrates, and fat, leading to protein-energy malnutrition (PEM). Diet-based strategies are the most promising approach for a sustainable control of PEM. This study aimed to investigate the effects of soy flour inclusion on the nutritional properties, consumer preference, purchase intent, and willingness to pay for wheat-based fritters. Read More

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October 2018
4 Reads

Serum levels of the adipokine zinc-alpha2-glycoprotein (ZAG) predict mortality in hemodialysis patients.

Kidney Int 2018 Nov;94(5):983-992

Department of Nephrology and Nutrition, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France; Laboratoire CarMeN, INSERM U1060, INRA U1397, Université Lyon 1, INSA-Lyon, Villeurbanne, France. Electronic address:

Wasting has been associated with increased cardiovascular and all-cause mortality in chronic kidney disease (CKD). We investigated whether serum zinc-alpha2-glycoprotein (ZAG), a potent cachectic and lipid-mobilizing factor that is increased in patients with CKD, predicts clinical outcomes in patients on chronic hemodialysis. We quantified serum ZAG at baseline in a prospective cohort of 252 patients undergoing maintenance hemodialysis. Read More

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November 2018
26 Reads

Global Prevalence of Protein-Energy Wasting in Kidney Disease: A Meta-analysis of Contemporary Observational Studies From the International Society of Renal Nutrition and Metabolism.

J Ren Nutr 2018 Nov;28(6):380-392

Division of Biostatistics (FT), Department of Preventive Medicine, and Division of Nephrology, Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.

Objective: To better define the prevalence of protein-energy wasting (PEW) in kidney disease is poorly defined.

Methods: We performed a meta-analysis of PEW prevalence from contemporary studies including more than 50 subjects with kidney disease, published during 2000-2014 and reporting on PEW prevalence by subjective global assessment or malnutrition-inflammation score. Data were reviewed throughout different strata: (1) acute kidney injury (AKI), (2) pediatric chronic kidney disease (CKD), (3) nondialyzed CKD 3-5, (4) maintenance dialysis, and (5) subjects undergoing kidney transplantation (Tx). Read More

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November 2018
9 Reads
2.550 Impact Factor

Racial and Ethnic Disparities in the Obesity Paradox.

Am J Kidney Dis 2018 Nov;72(5S1):S26-S32

Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California Irvine, School of Medicine, Orange, CA; Department of Medicine, Long Beach Veteran Affairs Health System, Long Beach, CA; Program for Public Health, University of California Irvine, Irvine, CA; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA. Electronic address:

Obesity is a major risk factor for cardiovascular disease and worse survival in the general population. However, in patients with end-stage renal disease (ESRD), higher body mass index and indexes of body fat and muscle are associated with better survival. Furthermore, these associations, which some have described as the obesity paradox, are more consistent in African American patients being treated with hemodialysis when compared with other racial-ethnic groups. Read More

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November 2018
3 Reads
5.900 Impact Factor

Differences in Amino Acid Loss Between High-Efficiency Hemodialysis and Postdilution and Predilution Hemodiafiltration Using High Convection Volume Exchange-A New Metabolic Scenario? A Pilot Study.

J Ren Nutr 2018 Oct 16. Epub 2018 Oct 16.

Former Director of Territorial, Department of Nephrology and Dialysis, ASL Cagliari, Cagliari, Italy; Member of Italian Society of Nephrology, Cagliari, Italy. Electronic address:

Objective: The objective of the study was to quantify the loss of total amino acids (TAAs), nonessential amino acids, essential amino acids, and branched chain amino acids (BCAAs) produced by high-efficiency hemodialysis (HEHD), postdilution hemodiafiltration (HDFpost), and predilution hemodiafiltration (HDFpre) using high ultrafiltration volumes; and to define the specific AA losses registered in HEHD, HDFpost, and HDFpre; to identify a potential metabolic and nutritional decline into protein energy wasting; to compare AA analysis of arterial blood samples taken from healthy controls and patients with end-stage renal disease undergoing hemodialysis.

Design And Methods: Identical dialysis monitors, membranes, and dialysate/infusate were used to homogenize extracorporeal body influence. Ten patients were recruited and randomized to receive treatment with HEHD, HDFpost, and HDFpre it was used on-line dialytic water methodologies (OL); patients' AA arterial concentrations were measured at the start and on completion of dialysis; TAA from the dialyzer filter was calculated, and baseline levels were subsequently compared with findings obtained 1 year later. Read More

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October 2018
11 Reads

Improving nutritional care quality in the orthopedic ward of a Septic Surgery Center by implementing a preventive nutritional policy using the Nutritional Risk Score: a pilot study.

Eur J Clin Nutr 2018 Oct 18. Epub 2018 Oct 18.

Clinical Nutritionist, Apples, Switzerland.

Background/objectives: Septic Surgery Center (SSC) patients are at a particularly high risk of protein-energy malnutrition (PEM), with a prevalence of 35-85% found in various studies. Previous collaboration between our hospital's SSC and its Clinical Nutrition Team (CNT) only focussed on patients with severe PEM. This study aimed to determine whether it was possible to improve the quality of nutritional care in septic surgery patients with help of a nutritional policy using the Nutritional Risk Score (NRS). Read More

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October 2018
1 Read

Weight improvement with the use of protein and energy enriched nutritional formula in infants with a prolonged PICU stay.

J Hum Nutr Diet 2018 Oct 14. Epub 2018 Oct 14.

Department of Paediatrics and Paediatric Surgery, Intensive Care Unit, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Reaching an optimal nutritional intake is challenging in critically ill infants. One possible way to minimise nutritional deficits is the use of protein and energy-enriched (PE)-formulas. We aimed to describe weight achievement and gastrointestinal symptoms in infants admitted to the paediatric intensive care unit (PICU) while receiving PE-formula for a prolonged period. Read More

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October 2018

Impact of dietary macronutrient profile on feline body weight is not consistent with the protein leverage hypothesis.

Br J Nutr 2018 Dec 12;120(11):1310-1318. Epub 2018 Oct 12.

WALTHAM Centre for Pet Nutrition,Waltham on the Wolds,Melton MowbrayLE14 4RT, UK.

The protein leverage hypothesis proposes that the need to prioritise protein intake drives excess energy intake (EI) when the dietary ratio of protein to fat and carbohydrate is reduced. We hypothesised that cats may become prone to overconsuming energy content when moderate protein diets were offered, and considered the potential influence of fat and carbohydrate on intake. To determine the effect of dietary protein and macronutrient profile (MNP) on EI, weight and body composition, cats (1-4 years) were offered food in excess of energy requirements (ER). Read More

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December 2018
4 Reads

Influence of dietary protein intake on body composition in chronic kidney disease patients in stages 3-5: A cross-sectional study.

Nefrologia 2018 Nov - Dec;38(6):647-654. Epub 2018 Oct 4.

Department of Nephrology, Advanced-chronic Kidney Disease Unit, Hospital Universitario de la Princesa, 28006 Madrid, Spain.

Introduction: A controlled protein intake has shown beneficial effects to preserve renal function and nutritional status in chronic kidney disease (CKD) patients. This study aimed to analyze usual dietary protein intake and its potential contribution to body composition in CKD patients in stages 3-5.

Method: Cross-sectional study in 134 CKD patients in stages 3-5 (mean e-GFR: 19. Read More

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October 2018
2 Reads

Is Dietary Protein Intake Predictive of 1-Year Mortality in Dialysis Patients?

Am J Med Sci 2018 Sep 19;356(3):234-243. Epub 2018 Jun 19.

Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia; Charlie Norwood VA Medical Center, Augusta, Georgia. Electronic address:

Background: High mortality in dialysis patients may be associated with protein-energy wasting (PEW) syndrome characterized by progressively depleted protein and energy stores. While early diagnosis and treatment of PEW can reduce mortality, clinically practical measures for its detection are lacking. Poor dietary protein intake (DPI) is associated with risk of malnutrition and PEW. Read More

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September 2018
1 Read

Human immunodeficiency virus status in malnourished children seen at Lagos.

PLoS One 2018 4;13(10):e0200435. Epub 2018 Oct 4.

Massey Street Children's Hospital, Lagos Island, Lagos, Nigeria.

Introduction: Human immunodeficiency virus and protein energy malnutrition are still prevalent in Nigeria and the occurrence of the two conditions together confers a poor prognosis. The aim of this study was to determine the current categories of malnutrition amongst under-5 children in Lagos, document their HIV status and determine any peculiarities in the clinical features, haematological and some biochemical profile in these children.

Methods: The study was a cross-sectional study conducted at the Paediatric departments of the Lagos University Teaching Hospital and the Massey Street Children's Hospital, both in Lagos, over a 6-month period. Read More

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October 2018
2 Reads
3.230 Impact Factor

Low protein diets for non-diabetic adults with chronic kidney disease.

Cochrane Database Syst Rev 2018 10 4;10:CD001892. Epub 2018 Oct 4.

Department of Nephrology, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, Australia, 2145.

Background: Chronic kidney disease (CKD) is defined as reduced function of the kidneys present for 3 months or longer with adverse implications for health and survival. For several decades low protein diets have been proposed for participants with CKD with the aim of slowing the progression to end-stage kidney disease (ESKD) and delaying the onset of renal replacement therapy. However the relative benefits and harms of dietary protein restriction for preventing progression of CKD have not been resolved. Read More

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October 2018
2 Reads

Malnutrition in type 2 diabetic patients does not affect healing of foot ulcers.

Acta Diabetol 2018 Oct 3. Epub 2018 Oct 3.

Service Endocrinologie, Diabétologie et Maladies Métaboliques, Hôpital François Mitterrand, CHU Dijon, BP 77908, 21079, Dijon, France.

Aim: Protein-energy malnutrition is known to be involved in wound healing. While wound healing in patients with diabetic foot ulcers (DFU) is a complex and multifactorial process, the role of malnutrition in this case has rarely been explored. The objective of this study was to determine whether the nutritional status of diabetic patients influences the healing of DFU. Read More

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October 2018
5 Reads

Chronic inflammation in end-stage renal disease and dialysis.

Nephrol Dial Transplant 2018 Oct;33(suppl_3):iii35-iii40

Division of Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden.

Under normal conditions, inflammation is a protective and physiological response to various harmful stimuli. However, in several chronic debilitating disorders, such as chronic kidney disease, inflammation becomes maladaptive, uncontrolled and persistent. Systemic persistent inflammation has, for almost 20 years, been recognized as a major contributor to the uraemic phenotype (such as cardiovascular disease, protein energy wasting, depression, osteoporosis and frailty), and a predictor of cardiovascular and total mortality. Read More

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October 2018
2 Reads

Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

Br J Pharmacol 2018 Sep 30. Epub 2018 Sep 30.

The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background And Purpose: Liquorice is the root of Glycyrrhiza glabra, which is a popular food in Europe and China that has previously shown benefits for skeletal fatigue and nutrient metabolism. However, the mechanism and active ingredients remain largely unclear. The aim of this study was to investigate the active ingredients of liquorice for muscle wasting and elucidate the underlying mechanisms. Read More

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September 2018
15 Reads

Secular trend towards ultra-processed food consumption and expenditure compromises dietary quality among Taiwanese adolescents.

Food Nutr Res 2018 17;62. Epub 2018 Sep 17.

School of Public Health, National Defense Medical Center, Taipei, Taiwan.

Objective: To compare two Nutrition and Health Surveys in Taiwan (NAHSITs) 15-18 years apart to evaluate secular changes in ultra-processed food (UPF) consumption and expenditure among Taiwanese adolescents aged 16-18 years and the influences of such changes on dietary quality.

Design: This cross-sectional study was based on two representative surveys (NAHSIT 1993-1996, = 788; NAHSIT 2011, = 1,274) of senior high school students. Dietary information and food expenditure were based on 24-h dietary recall. Read More

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September 2018

From mutations to mechanisms and dysfunction via computation and mining of protein energy landscapes.

BMC Genomics 2018 Sep 24;19(Suppl 7):671. Epub 2018 Sep 24.

Department of Computer Science, George Mason University, Fairfax, 22030, VA, USA.

Background: The protein energy landscape underscores the inherent nature of proteins as dynamic molecules interconverting between structures with varying energies. Reconstructing a protein's energy landscape holds the key to characterizing a protein's equilibrium conformational dynamics and its relationship to function. Many pathogenic mutations in protein sequences alter the equilibrium dynamics that regulates molecular interactions and thus protein function. Read More

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September 2018

Clinical Significance of Phase Angle in Non-Dialysis CKD Stage 5 and Peritoneal Dialysis Patients.

Nutrients 2018 Sep 19;10(9). Epub 2018 Sep 19.

Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju, Kang-won 26426, Korea.

Background: Fluid overload and protein-energy wasting (PEW) are common in patients with end-stage renal disease (ESRD) and lead to a poor prognosis. We aimed to evaluate the volume and nutritional status of ESRD patients and to determine the clinical significance of phase angle (PhA).

Methods: This study was a cross-sectional comparison of bioimpedance spectroscopy (BIS) findings in patients with non-dialysis chronic kidney disease (CKD) stage 5 (CKD5-ND, = 80) and age/sex-matched peritoneal dialysis patients (PD, = 80). Read More

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September 2018

Quantitative EEG Tomography of Early Childhood Malnutrition.

Front Neurosci 2018 28;12:595. Epub 2018 Aug 28.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

The goal of this study is to identify the quantitative electroencephalographic (qEEG) signature of early childhood malnutrition [protein-energy malnutrition (PEM)]. To this end, archival digital EEG recordings of 108 participants in the Barbados Nutrition Study (BNS) were recovered and cleaned of artifacts (46 children who suffered an episode of PEM limited to the first year of life) and 62 healthy controls). The participants of the still ongoing BNS were initially enrolled in 1973, and EEGs for both groups were recorded in 1977-1978 (at 5-11 years). Read More

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August 2018
2 Reads

[Food and nutrition liaison committees in healthcare facilities].

Soins Gerontol 2018 Sep - Oct;23(133):25-26

Service de soins de suite et réadaptation orthogériatrique et polyvalent, filière postopératoire, GHU La Pitié-Salpêtrière - Charles-Foix, AP-HP, 7 avenue de la République, 94205 Ivry-sur-Seine, France; DHU Fight Aging and Stress - FAST, UMR 8256 B2A Biological Adaptation and Ageing, boîte 14, université Pierre-et-Marie-Curie, 9 quai Saint-Bernard, 75005 Paris, France. Electronic address:

Since 2002, all healthcare facilities must have a food and nutrition liaison committee. The aim is to improve the management of food and nutrition related issues in hospital. The players concerned undertake a global and cross-disciplinary approach to ensure better food, notably for elderly patients at risk of protein-energy malnutrition. Read More

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September 2018

[Malnutrition in the elderly, screening and treatment].

Authors:
Cyril Sellier

Soins Gerontol 2018 Sep - Oct;23(133):12-17

Hôpital Ambroise-Paré (AP-HP), 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address:

Undernutrition is defined as an imbalance between the body's energy intake and requirements. It is present in 30 to 70% of hospitalised elderly people and its consequences are severe. Systematic screening and early treatment are an integral part of global geriatric care. Read More

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September 2018
2 Reads

Nutrient consumption and associated factors among school age children in Dewa Chefe District, northeast Ethiopia: a cross-sectional study.

BMC Res Notes 2018 Sep 17;11(1):669. Epub 2018 Sep 17.

Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Inadequate nutrient consumption causes protein energy malnutrition and micronutrient deficiencies and related consequences, including poor physical growth and intellectual development. However, literatures showing quantitative measurement of dietary intake of children are limited in Ethiopia. Therefore, this study investigated nutrient consumption and associated factors among school age children (7-9 years) in Dewa Cheffe District, northeast of Ethiopia. Read More

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September 2018
10 Reads

Regulation of mitochondrial biosynthesis and function by dietary carbohydrate levels and lipid sources in juvenile blunt snout bream Megalobrama amblycephala.

Comp Biochem Physiol A Mol Integr Physiol 2019 Jan 7;227:14-24. Epub 2018 Sep 7.

Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang Road, Nanjing 210095, People's Republic of China. Electronic address:

This study aimed to investigate the effects of dietary non-protein energy adjustments on the mitochondrial biosynthesis and function of juvenile Megalobrama amblycephala. Fish (average weight: 37.98 ± 0. Read More

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January 2019
1 Read

A systematic review, meta-analysis and meta-regression of the prevalence of protein-energy malnutrition: associations with geographical region and sex.

Age Ageing 2018 Sep 5. Epub 2018 Sep 5.

Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, Australia.

Background: protein-energy malnutrition is a major health concern in home-dwelling older adults, particularly in the context of an ageing population. Therefore, a systematic review and meta-analysis was undertaken to determine the prevalence of malnutrition among older adults living independently in the community according to geographical region, sampling frame, rurality and sex.

Methods: six electronic databases were searched until September 2016. Read More

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September 2018
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Amino acid profile after oral nutritional supplementation in hemodialysis patients with protein-energy wasting.

Nutrition 2019 Jan 11;57:231-236. Epub 2018 Jul 11.

Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdańsk, Poland.

Objectives: Protein-energy wasting (PEW) is highly prevalent in patients on hemodialysis (HD). Oral nutritional supplementation (ONS) is recommended for malnourished patients on HD. The aim of this study was to evaluate ONS on plasma amino acid in HD patients with PEW. Read More

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January 2019
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Treatment of malnutrition decreases complication rates and shortens the length of hospital stays in a radiation oncology department.

Strahlenther Onkol 2018 Nov 4;194(11):1049-1059. Epub 2018 Sep 4.

Nutrition Support Team, University Hospital Tuebingen, Tuebingen, Germany.

Purpose: The nutritional status of inpatients influences the therapeutic outcome. Malnutrition is a common comorbidity in oncological patients. Both radio- and radiochemotherapy may contribute to the additional deterioration of the nutritional status. Read More

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November 2018

The Effect of Low Protein Energy-Rich Diets on Plasma Hepatic Markers, Hepatic Damage, and Discrimination Reversal Learning in Young Female Chicks.

Front Vet Sci 2018 23;5:107. Epub 2018 May 23.

Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada.

Consumption of low protein energy-rich (LPER) diets increases susceptibility to metabolic disease in mammals, such as hepatic damage, and can have an adverse effect on cognition. However, the effects of these diets on both physical and mental welfare have not been investigated in domestic meat chickens. Female chicks received a low protein energy-rich or a standard control diet from 21 to 51 days of age. Read More

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May 2018
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Linking organochlorine exposure to biomarker response patterns in Anurans: a case study of Müller's clawed frog (Xenopus muelleri) from a tropical malaria vector control region.

Ecotoxicology 2018 Nov 1;27(9):1203-1216. Epub 2018 Sep 1.

Water Research Group, Unit for Environmental Sciences and Management, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

Organochlorine pesticides are highly persistent in aquatic ecosystems. Amphibians, specifically anurans, play an intricate part in the aquatic food web, and have very permeable skin which makes them prone to bioaccumulation of persistent pollutants. In this study the bioaccumulation of various legacy organochlorine pesticides (OCPs)-including dichlorodiphenyltrichloroethane (DDT), currently used for malaria vector control (MVC)-was assessed along with a set of biomarker responses in Müller's clawed frog Xenopus muelleri collected from the lower Phongolo River floodplain in South Africa. Read More

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November 2018
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