Search Our Scientific Publications & Authors

Saudi J Med Med Sci 2019 Jan-Apr;7(1):51-52. Epub 2018 Dec 14.

Department of Nephrology, La Rabta Hospital, Tunis, Tunisia.

BMC Neurol 2019 Feb 12;19(1):26. Epub 2019 Feb 12.

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.

Background: Mixed cerebrovascular disease is a diagnostic entity that presents with hemorrhagic and ischemic stroke clinically and/or subclinically. Here, we report a patient with mixed vascular risk factors, who presented with multiple intracerebral hemorrhages and a simultaneously occurring cerebral infarction with hemorrhagic transformation.

Case Presentation: A 63-year-old male with no history of trauma or prior neurological disease presented with a sudden onset of weakness in his right limbs, followed by an episode of focal seizure without impaired awareness. Read More

J Thromb Haemost 2019 Feb 11. Epub 2019 Feb 11.

Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.

Essentials Protein S and FV-Short are synergistic cofactors to Tissue Factor Pathway Inhibitor α (TFPIα). An assay for the TFPIα synergistic cofactor activity of protein S with FV-Short was developed. The assay was specific for the synergistic TFPIα-cofactor activity of free protein S. Read More

Oper Neurosurg (Hagerstown) 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.

The superficial temporal artery (STA) to the middle cerebral artery (MCA) bypass is the most common bypass type for revascularization to treat cerebral ischemia. If the ipsilateral STA is not available for anastomosis, various options for bypass conduits can be exercised. When the entire ipsilateral external carotid and its branches are not available, the contralateral STA may be used as a donor artery through an interposition graft. Read More

Thromb Haemost 2019 Mar 22;119(3):449-460. Epub 2019 Jan 22.

Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Protein S (PS) deficiency is associated with a 10-fold increased risk of venous thromboembolism (VTE), but its diagnosis is quite difficult and complicated. In this study, we identified 53 unrelated pedigrees with PS deficiency in China. Data of their clinical characteristics and laboratory examinations were collected. Read More

Turk J Haematol 2019 Jan 17. Epub 2019 Jan 17.

Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan

JBJS Case Connect 2018 Oct-Dec;8(4):e82

Orthopedic Residency Program, OhioHealth Doctors Hospital, Columbus, Ohio.

Case: Protein S deficiency, a hypercoagulable thrombophilia, often results in venous thromboembolism. Nontraumatic compartment syndrome in a patient with protein S deficiency has not been well publicized. Herein, we present a rare case of nontraumatic compartment syndrome of the hand and the thigh in a 48-year-old woman with a known history of protein S deficiency; emergency fasciotomies were needed. Read More

Thromb Res 2019 02 6;174:1-4. Epub 2018 Dec 6.

Division of Vascular Surgery, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

J Neurovirol 2019 Feb 26;25(1):137-140. Epub 2018 Nov 26.

Department of Medical Research, Gundersen Health System, Mail Stop C03-006B, 1836 South Avenue, La Crosse, WI, 54601, USA.

A child with vertical transmission of human immunodeficiency virus refractory to therapy developed zoster-induced protein S deficiency and recurrent strokes. Extensive carotid arteritis was found postmortem. The carotid tissue was positive for herpes varicella zoster by polymerase chain reaction, as were immunofixation stains of the arterial wall. Read More

Intern Med 2019 Mar 19;58(6):893. Epub 2018 Nov 19.

Department of Geriatric Medicine, Osaka University School of Medicine, Japan.

Endosc Int Open 2018 Nov 7;6(11):E1283-E1288. Epub 2018 Nov 7.

Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Esophagogastric variceal bleeding (EGVB) is common in patients with portal vein thrombosis (PVT). Hereditary deficiencies in natural anticoagulant proteins, such as protein S, might contribute to PVT. However, recurrent EGVB caused by PVT in patients with protein S deficiency is seldom reported. Read More

Hematology 2019 Dec 18;24(1):159-165. Epub 2018 Oct 18.

a Department of Medicine, Faculty of Medicine , Chulalongkorn University and King Chulalongkorn Memorial Hospital , Bangkok 10330 , Thailand.

Introduction: Studies in Western countries show that VTE recurrent rates are lower in the presence of a transient provoking factor, older age, female sex and/or hormonal use, while thrombophilia (factor V Leiden or prothrombin mutation) has no predictive role. This study aimed to determine the incidence and risk factors of recurrent VTE in Asian patients.

Method: This is a retrospective cohort study in adult VTE patients who were diagnosed during 2004-2014, had no active cancer and followed-up for at least 1 year. Read More

Asian J Endosc Surg 2018 Sep 26. Epub 2018 Sep 26.

Division of Surgery, Ome Municipal General Hospital, Tokyo, Japan.

Patients with protein S deficiency are prone to developing thrombosis. During laparoscopic surgery in patients with protein S deficiency, there is a risk of deep venous thromboembolism. In the present case, the patient was a 66-year-old man. Read More

Intern Med 2019 Feb 12;58(3):381-385. Epub 2018 Sep 12.

Department of Cardiology, Toyonaka Municipal Hospital, Japan.

An aortic mural thrombus (AMT) on a non-atherosclerotic wall is a rare but important cause of arterial thromboembolism. We herein report two cases of AMT in the thoracic aorta. Both showed multiple hypercoagulable factors (case 1: protein S deficiency and positive finding of anti-cardiolipin antibody; case 2: protein C deficiency, gastric cancer, and cisplatin-based chemotherapy) and were successfully treated with anticoagulation. Read More

Med J Malaysia 2018 Aug;73(4):185-189

Liaquat National Hospital and Medical College, Department of Biostatics, Karachi, Pakistan.

Background: It is being increasingly recognised that thalassemia major patients, like intermedia, have increased propensity for thromboembolism. Deficiency of natural anticoagulants is more recently defined finding contributing to the hypercoagulable state. The aim this study is to determine natural anticoagulants levels and their correlation with maternal characteristics, haematological and biochemical markers. Read More

Case Rep Obstet Gynecol 2018 9;2018:6324362. Epub 2018 Jul 9.

Department of Pathology, Wayne State University, Detroit, MI, USA.

Background: Thrombosis of one of the umbilical arteries can be associated with adverse pregnancy outcomes such as stillbirth and severe intrauterine growth restriction (IUGR).

Case: A 21-year-old gravida 1 patient, with a history of 3-vessel cord at 20 weeks, presented at 29 weeks with a single umbilical artery. The estimated fetal weight measurements at 26 weeks, 29 weeks, and 31 weeks were at the 27th percentile, the 26th percentile, and less than the 5th percentile, respectively. Read More

An Bras Dermatol 2018 Jul-Aug;93(4):612-613

Service of Dermatology, Universidade Federal do Espírito Santo, Vitória (ES), Brazil.

Thromb Res 2018 09 6;169:15-22. Epub 2018 Jul 6.

Institute of Cardiovascular Research, Royal Holloway, University of London (ICR2UL), Egham, United Kingdom. Electronic address:

Introduction: A wide variety of non-genetic and genetic factors have been shown to associate with increased risk for cerebral venous thrombosis (CVT). However, there is a paucity of risk factor data and conclusions about their impact are often conflicting. Herein, we quantified the associations of non-genetic and genetic risk factors for CVT in adults. Read More

Eur Arch Otorhinolaryngol 2018 Aug 8;275(8):1971-1977. Epub 2018 Jun 8.

Audiology and Otosurgery Unit, Department of Surgery, Cochlear Implant Referral Center, "Bambino Gesù" Pediatric Hospital, Piazza Sant'Onofrio, 4, 00165, Rome, Italy.

Purpose: To describe the prevalent clinical, laboratory, and radiological features of otogenic lateral sinus thrombosis (OLST) in children; to identify clinical predictors of outcome; to propose a management algorithm derived from experience.

Methods: A retrospective review was conducted of the clinical records of patients with OLST, treated in a single tertiary care referral center for pediatric disease from 2006 to 2017. The inclusion criteria were pediatric age (0-16 years) and OLST diagnosis confirmed by a pre- and post-contrast CT or venography-MRI scan. Read More

Thromb Res 2018 08 2;168:28-30. Epub 2018 Jun 2.

Center for Primary Health Care Research, Lund University and Region Skåne, Malmö, Sweden. Electronic address:

J Thromb Thrombolysis 2018 Aug;46(2):244-245

Laboratoire PACEA, UMR 5199, Université de Bordeaux, Bordeaux, France.

Eur Rev Med Pharmacol Sci 2018 May;22(9):2742-2750

Department of Vascular Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

Objective: Budd-Chiari syndrome (BCS) is a life-threatening hepatic disease characterized by hepatic venous obstruction at the level of hepatic vein, hepatic venules, or inferior vena cava. No evidence reported the relationship between the endothelial progenitor cells and the deficiency of factor V Leiden and protein C in patients with primary Budd-Chiari syndrome.

Patients And Methods: We recruited participants between June 2014 and July 2015. Read More

Medicine (Baltimore) 2018 May;97(19):e0714

Department of Vascular Surgery, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

Rationale: Protein S (PS) deficiency that can be inherited or acquired is an independent risk factor for venous thromboembolism (VTE).

Patient Concerns: In this report, we present a case of recurrent pulmonary embolism (PE) and deep venous thrombosis (DVT) due to PS deficiency.

Diagnoses: A 32-year-old male patient with significant decrease in PS activity was detected by laboratory tests. Read More

Case Rep Hematol 2018 23;2018:5217301. Epub 2018 Jan 23.

Department of Respiratory Medicine, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Okinawa, Japan.

Protein S (PS) deficiency, an autosomal dominant hereditary thrombophilia, is more prevalent in East Asian populations than in Caucasians. PS-deficient patients have historically been administered a heparin product followed by warfarin for the treatment and secondary prevention of venous thromboembolism (VTE). However, warfarin can be ineffective or causes detrimental effects in rare cases. Read More

Open AIDS J 2018 28;12:6-10. Epub 2018 Feb 28.

Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Foggia, Viale L. Pinto 71131 Foggia, Italy.

Background: HIV infection is a known prothrombotic condition but factors involved are still controversial. A role for antiretrovirals, especially protease inhibitors, was advocated.

Objectives: The study aimed to analyze the levels of anticoagulant proteins in virally suppressed HIV-infected subjects treated with different anti-retroviral regimens. Read More

Ann Vasc Dis 2017 Dec;10(4):364-370

The Vein & Vascular Center, Aisei Hospital, Tokyo, Japan.

In our varicose vein center, on a trial basis, among the patients with asymptomatic calf deep vein thrombosis (CDVT) we carefully selected the patients for varicose vein surgery using the requirements as follows; 1) the patients had varicose veins with incompetent saphenous veins, 2) sequential examination including DUS confirmed stability and clinical insignificance of asymptomatic CDVT, 3) the patients do not have any risk factors for DVT such as a coagulation profile disorder (antithrombin deficiency, protein C deficiency, protein S deficiency, or antiphospholipid syndrome) or malignancies, 4) surgery is possible under local anesthesia alone, and 5) the patients can understand the concept of asymptomatic CDVT and undergo the surgery on their own will and informed consent. The patients who fulfilled these conditions underwent the varicose vein surgery. Twenty-eight patients with 30 limbs with varicose veins had asymptomatic CDVT, found by preoperative duplex ultrasonography (DUS). Read More

JA Clin Rep 2018 15;4(1):17. Epub 2018 Feb 15.

1Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke-City, Tochigi 329-0498 Japan.

Protein S deficiency patient is characterized by recurrent thrombosis, and its risk is higher intraoperatively, especially in cardiac surgery involving cardiopulmonary bypass. Two heparin cessation periods are defined in cardiac surgery. One is the period between the cessation of heparin 4 to 5 h before surgery and the heparinization prior to cardiopulmonary bypass. Read More

Rev Esp Geriatr Gerontol 2018 Sep - Oct;53(5):304-305. Epub 2018 Feb 10.

Servicio de Urgencias, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

J Med Vasc 2018 Feb 26;43(1):56-60. Epub 2017 Dec 26.

Équipe de recherche en santé et nutrition du couple mère enfant, service de réanimation néonatale, faculté de médecine et de pharmacie, hôpital d'enfants de Rabat, université Mohamed V, Rabat, Maroc.

Arterial thrombosis of the newborn is rare and associated with poor prognosis, often attributed to umbilical arterial catheterization. The aortic and spontaneous forms are exceptional. Its severity requires fast and effective treatment. Read More

J Investig Med High Impact Case Rep 2018 Jan-Mar;6(1):2324709617750179. Epub 2018 Jan 9.

University of Florida, Jacksonville, FL, USA.

A 58-year-old male, known to have hepatitis C virus (HCV), presented with intermittent headaches and left-sided sensorimotor symptoms. There were no focal neurological deficits on examination. Electrocardiogram was unremarkable. Read More

Pediatr Infect Dis J 2018 Jul;37(7):e201-e203

From the Service de Chirurgie Pédiatrique.

Postvaricella protein S deficiency is a rare and severe disease. We report a case of extensive necrotic skin lesions of acute onset 7 days after varicella in a 4-year-old girl. Protein S antigen and activity were <10%, and antiprotein S antibodies were detected. Read More

J Genet 2017 Dec;96(6):1047-1051

The John Paul II Hospital, 31-202 Kraków, Poland.

Protein S (PS) is a vitaminK-dependent glycoproteinwhich plays an important role in the regulation of blood coagulation. PS deficiency has been found in 1.5-7% of thrombophilic patients. Read More

Clin Case Rep 2017 12 3;5(12):2062-2065. Epub 2017 Nov 3.

Department of Human Genetics Instituto Nacional de Saúde Doutor Ricardo Jorge Lisbon Portugal.

Our results prove that c.1871-14T>G is causative of type I PS deficiency, highlighting the importance of performing mRNA-based studies in order to evaluate variants pathogenicity. We evidence the increased risk of venous thromboembolism associated with this cryptic splice-site variant if present in patients with PS deficiency. Read More

J Med Case Rep 2017 Nov 9;11(1):315. Epub 2017 Nov 9.

Department of GI Surgery, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Background: Acute mesenteric ischemia poses a diagnostic challenge due to nonspecific clinical clues and lack of awareness owing to its rarity. Ischemia due to mesenteric venous thrombosis has a good prognosis compared to arterial cause and can be managed conservatively with early diagnosis. The portomesenteric venous system is an unusual site of thrombosis in patients with protein S deficiency, and its thrombosis is an uncommon cause of acute mesenteric ischemia. Read More

BMJ 2017 Oct 26;359:j4452. Epub 2017 Oct 26.

Department of Hematology, Erasmus University Medical Centre, Postbus 2040, 3000 CA, Rotterdam, Netherlands.

 To provide evidence to support updated guidelines for the management of pregnant women with hereditary thrombophilia in order to reduce the risk of a first venous thromboembolism (VTE) in pregnancy. Systematic review and bayesian meta-analysis. Embase, Medline, Web of Science, Cochrane Library, and Google Scholar from inception through 14 November 2016. Read More

PLoS One 2017 17;12(10):e0185785. Epub 2017 Oct 17.

Division of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Hereditary thrombophilia (HT) is a genetic predisposition to thrombosis. Asian mutation spectrum of HT is different from Western ones. We investigated the incidence and clinical characteristics of HT in Korean patients with unprovoked venous thromboembolism (VTE). Read More

Arch Pathol Lab Med 2018 Jan 18;142(1):70-74. Epub 2017 Sep 18.

From the Department of Pathology, Massachusetts General Hospital, Boston.

Context: - Rivaroxaban causes a false increase in activated protein C resistance (APCR) ratios and protein S activity.

Objective: - To investigate whether this increase masks a diagnosis of factor V Leiden (FVL) or protein S deficiency in a "real-world" population of patients undergoing rivaroxaban treatment and hypercoagulation testing.

Design: - During a 2. Read More

Semin Thromb Hemost 2018 Mar 13;44(2):176-184. Epub 2017 Sep 13.

Department of Translational Medicine, Lund University, Malmö, Sweden.

Protein S is a vitamin K-dependent plasma glycoprotein circulating in plasma at a concentration of around 350 nM. Approximately 60% of protein S in human plasma is bound to the complement regulatory protein C4b-binding protein (C4BP) in a high-affinity, high-molecular-weight complex. Protein S in plasma has multiple anticoagulant properties and heterozygous protein S deficiency is associated with increased risk of venous thrombosis. Read More

Rev Med Interne 2018 Jan 1;39(1):50-53. Epub 2017 Sep 1.

Service de dermatologie, centre hospitalier Victor-Dupouy, 69, rue du Lieutenant-Colonel-Prudhon, 95100 Argenteuil, France.

Introduction: Patients treated by vitamin K antagonists (VKA) represent 1% of the population in France. We report a case of atypical necrotic leg ulcers induced by VKA.

Case Report: A 84-year-old woman was referred to our dermatology department because of necrotic leg ulcers that developed for the past 5weeks, and appeared spontaneously after the introduction of a VKA, fluindione. Read More

Pol Arch Intern Med 2017 08 3;127(7-8):465-467. Epub 2017 Sep 3.

J Perinat Med 2018 May;46(4):411-417

Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Lublin, Poland.

Aim: (1) To evaluate the prevalence of inherited thrombophilia in pregnant women with adverse pregnancy outcomes: intrauterine growth retardation (IUGR), preeclampsia (PE) and placental abruption. (2) To assess the impact of inherited thrombophilia on the nature of obstetric complications. (3) To assess levels of protein S, protein C, antithrombin III and homocysteine in pregnant women with adverse pregnancy outcomes. Read More

BMC Res Notes 2017 Jul 25;10(1):312. Epub 2017 Jul 25.

Western Australian Centre for Thrombosis and Haemostasis, Murdoch University, Murdoch, Australia.

Background: Accumulating evidence indicate that circulating microRNAs (miRNAs) are useful independent non-invasive biomarkers, with unique miRNA signatures defined for various pathophysiological conditions. However, there are no established universal housekeeping miRNAs for the normalisation of miRNAs in body fluids. We have previously identified an oestrogen-responsive miRNA, miR-494, in regulating the anticoagulant, Protein S, in HuH-7 liver cells. Read More

Eur J Intern Med 2017 Oct 3;44:44-48. Epub 2017 Jul 3.

A. Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

Background: The role of thrombophilic and cardiovascular risk factors in different manifestations of retinal vein occlusion (RVO), i.e., central or branch RVO, and at different ages is still debated. Read More

J Matern Fetal Neonatal Med 2018 Oct 16;31(19):2590-2593. Epub 2017 Jul 16.

b Carnegie Imaging Center and Maternal Fetal Medicine Associates PLLC , New York , USA.

Objective: The primary objective of this study was to evaluate whether women with double thrombophilias have a greater risk for obstetric complications as compared with women who have single thrombophilias.

Study Design: This is a retrospective cohort study of all patients in a single practice with a clinically significant inherited thrombophilia and treated with anticoagulation between 2005 and 2013. Thrombophilias evaluated include: factor V Leiden, prothrombin G20210A gene mutation, protein S deficiency, protein C deficiency, and antithrombin III deficiency. Read More

Am J Med Genet A 2017 Sep 19;173(9):2359-2365. Epub 2017 Jun 19.

Medical Genomics Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

Patients with overgrowth and complex vascular malformation syndromes, including Proteus syndrome have an increased risk of thromboembolism. Proteus syndrome is a mosaic, progressive overgrowth disorder involving vasculature, skin, and skeleton, and caused by a somatic activating mutation in AKT1. We conducted a comprehensive review of the medical histories and hematologic evaluations of 57 patients with Proteus syndrome to identify potential risk factors for thrombosis. Read More

Pol Arch Intern Med 2017 08 13;127(7-8):512-523. Epub 2017 Jun 13.

INTRODUCTION    Inherited deficiencies of natural anticoagulants such as antithrombin (AT; gene: SERPINC1), protein C (PC; PROC), and protein S (PS; PROS1), with the prevalence in the general European population of 0.02% to 0.17%, 0. Read More

BMC Infect Dis 2017 05 18;17(1):354. Epub 2017 May 18.

Department of Internal Medicine, University of Zambia, P.O.Box 51237, Lusaka, Zambia.

Background: In Zambia, 14.2% of adults have HIV/AIDS. There has been a substantial and significant increase in patients hospitalized for ischaemic stroke with co-existing HIV infection. Read More

Ann Vasc Surg 2017 Aug 10;43:272-277. Epub 2017 May 10.

Division of Vascular and Endovascular Surgery, Department of Surgery and Orthpedics, Botucatu Medical School, UNESP, Botucatu, São Paulo, Brazil.

Background: Superficial vein thrombosis (SVT) is a common venous condition. Recent studies have shown that SVT is associated with high frequency of thromboembolic complications: from 22-37% for deep venous thrombosis and up to 33% for pulmonary embolism. Our goal was to assess the prevalence of major hereditary and acquired thrombophilic factors in patients with SVT. Read More

Rev Gastroenterol Peru 2017 Jan-Mar;37(1):87-90

Facultad de Medicina, Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú; Departamento de Gastroenterología, Hospital Antonio Lorena. Cusco, Perú.

Liver involvement is usually seen in patients infected with the human immunodeficiency virus (HIV), especially in patients coinfected with hepatitis B or C, in alcohol abuse, etc. However, there is a group of patients who develop liver involvement and portal hypertension of unspecified cause. Non-cirrhotic portal hypertension (NCPH) is a liver disorder recently described, but potentially serious. Read More

Acta Haematol 2017 6;137(4):201-206. Epub 2017 May 6.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo," Trieste, Italy.

The aim of this study is to investigate thrombogenesis and the hypercoagulable changes in pregnant women affected by thrombophilia who received low-molecular-weight heparin (LWMH) prophylaxis. We included 21 pregnant women affected by thrombophilia treated with LWMH and 20 nontreated normal pregnant women as the control group. The sample group of thrombophilic pregnant women included different conditions (factor V Leiden mutation, protein C deficiency, protein S deficiency, antiphospholipid antibodies syndrome, and combined defects). Read More