Int J Mol Sci 2021 Mar 17;22(6). Epub 2021 Mar 17.
Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, 50139 Florence, Italy.
The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, acts as 'polymodal cellular sensor' on primary sensory neurons where it mediates the peripheral and central processing of pain, itch, and thermal sensation. However, the TRPA1 expression extends far beyond the sensory nerves. In recent years, much attention has been paid to its expression and function in non-neuronal cell types including skin cells, such as keratinocytes, melanocytes, mast cells, dendritic cells, and endothelial cells. Read More