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Sci Rep 2019 Feb 7;9(1):1603. Epub 2019 Feb 7.

Philips Research, High Tech Campus 11, 5656 AE, Eindhoven, The Netherlands.

Signal transduction pathways are important in physiology and pathophysiology. Targeted drugs aim at modifying pathogenic pathway activity, e.g. Read More

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid.

Protein contact dermatitis is a chronic, recurring dermatitis triggered by type I hypersensitivity to protein allergen . We report a case caused by flours in a pastry chef. This article is protected by copyright. Read More

Part Fibre Toxicol 2019 01 8;16(1). Epub 2019 Jan 8.

Department of Environmental Medicine, University of Rochester Medical Center, New York, USA.

Background: The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxylation in MWCNT skin toxicity.

Results: MWCNTs were analyzed by transmission electron microscopy, zetasizer, and x-ray photoelectron spectroscopy to fully characterize the physical properties. Read More

Int Marit Health 2018;69(4):264-269

Maritime Health Unit, ISM Tarragona, Spain, Spain.

Background: Anisakis is a marine nematode. Its larvae can be found encysted in several species, both in the abdominal cavity and in the adjacent musculature. The most commonly affected commercial species are hake, whiting, cod, and mackerel. Read More

J Toxicol Sci 2018 ;43(12):741-749

Department of Dermatology, Tohoku University Graduate School of Medicine.

In all current in vitro skin sensitisation assays, DMSO is used to dissolve water-insoluble chemicals. However, our previous study suggested the superiority of the modified IL-8 Luc assay (mIL-8 Luc), in which X-VIVO 15 is used to dissolve chemicals, over the original assay using DMSO (oIL-8 Luc). In this study, to confirm the superiority of the mIL-8 Luc, we first increased the number of chemicals examined and demonstrated the superiority of the mIL-8 Luc, in which the mIL-8 Luc provided 87. Read More

Vet Immunol Immunopathol 2018 Dec 13;206:35-40. Epub 2018 Nov 13.

Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CL, The Netherlands; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, 0110, South Africa. Electronic address:

Keratinocytes (KC) are the main cellular components of the stratum corneum that constitutes a solid physical skin barrier representing the first line of defense against pathogens. Moreover, KC are potent producers of inflammatory mediators and antimicrobial peptides (AMP) when activated through their pattern recognition receptors. In atopic dermatitis (AD) the protective skin barrier may be compromised due to barrier disruption, secondary infection and accelerated secretion of inflammatory cytokines which may also affect AMP expression in the skin. Read More

Toxicol Sci 2018 Dec 4. Epub 2018 Dec 4.

Pharmaceutical Sciences Department, University of Oklahoma Health Science Center, 110 N. Stonewall, Oklahoma City, OK.

Irritant contact dermatitis (ICD), the most common occupational cutaneous illness, is an acute inflammatory response caused by topical irritant exposure. Multiple factors are associated with the manifestation and severity of ICD and contribute to the lack of effective prophylactic and treatment strategies. To determine the pathomechanism of ICD caused by the irritants, benzalkonium chloride (BKC) and JP-8 jet fuel, two mouse strains, C57BL/6 and Balb/c, were assessed due to their differential immune predispositions. Read More

J Clin Med 2018 Nov 27;7(12). Epub 2018 Nov 27.

Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.

Hexavalent chromium (Cr(VI)) is widely used in many industries but can induce contact dermatitis especially in cement industries. Many cement workers suffer from Cr(VI)-induced allergic contact dermatitis (ACD), and prevention and therapeutic strategies are still lacking. Pterostilbene (PT) is a natural compound predominantly found in blueberries. Read More

An Bras Dermatol 2018 Nov/Dec;93(6):829-835

Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP), Brazil.

Background: Allergic contact dermatitis to ion nickel (Ni+2) is an inflammatory dermatosis, common in industrialized countries. It involves the activation of nickel-specific T-cells, followed by proliferation and induction of a mixed profile of both proinflammatory and regulatory cytokines, suggesting that several T-cell subtypes (helper - Th and cytotoxic - Tc) are involved. A broader understanding of the cytokine profile may lead to new therapeutic approaches. Read More

Biosci Biotechnol Biochem 2019 Mar 10;83(3):525-530. Epub 2018 Nov 10.

c Department of Nutritional Science, Faculty of Health and Welfare Science , Okayama Prefectural University , Okayama , Japan.

Contact hypersensitivity (CHS) is frequently used as an animal model for human allergic contact dermatitis (ACD). Diets of pomegranate polyphenols (PPs) or soy isoflavones (SIs) each alleviated CHS symptoms; however, the effect of diets containing a mixture of PPs and SIs on CHS is unclear. We investigated the CHS-inhibitory effects of diets supplemented with a mixture of PPs and SIs at human physiologically relevant doses. Read More

Int J Mol Sci 2018 Nov 7;19(11). Epub 2018 Nov 7.

Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University, Gyeonggi-do 13120, Korea.

is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of grown on germinated (GRC) fermented with ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264. Read More

Curr Pharm Biotechnol 2018 ;19(11):910-916

Federal State Budgetary Institution "Research Institute of Basic and Clinical Immunology", Novosibirsk, Russian Federation.

Background: Large DNA poxviruses encode a diverse family of secreted proteins that modulate host inflammatory and antiviral responses, in particular by inhibiting one of the key players of the mammalian immune system, the tumor necrosis factor (TNF).

Methods: We investigated the effects of a recombinant variola (smallpox) virus TNF-decoy receptor (VARV-CrmB) in a murine model of contact dermatitis. Our results demonstrate that the VARV-CrmB protein significantly reduces the 2,4-dinitrochlorbenzene (DNCB)-induced migration of skin leukocytes during the sensitization phase and suppresses ear oedema during the elicitation phase of the contact reaction. Read More

Eur J Med Chem 2019 Jan 13;161:239-251. Epub 2018 Oct 13.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy.

A set of CB2R ligands, based on the thiophene scaffold, was synthesized and evaluated in in vitro assays. Compounds 8c-i, k, l, bearing the 3-carboxylate and 2-(adamantan-1-yl)carboxamido groups together with apolar alkyl/aryl substituents at 5-position or at 4- and 5-positions of the thiophene ring possess high CB2R affinity at low nanomolar concentration, good receptor selectivity, and agonistic functional activity. The full agonist 8g, showing the best balance between receptor affinity and selectivity, was tested in vitro in an experimental model of allergic contact dermatitis and proved to be able to block the release of MCP-2 in HaCaT cells at 10 μM concentration. Read More

J Ethnopharmacol 2019 Jan 17;229:190-204. Epub 2018 Oct 17.

Laboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil; Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Ethnopharmacological Relevance: Inflammatory skin diseases treatments currently used cause adverse effects. Nasturtium officinale (watercress) is used popularly as an anti-inflammatory. However, until now, no study proved its effectiveness as a topical treatment to inflammatory skin diseases. Read More

Food Chem 2019 Jan 9;272:33-38. Epub 2018 Aug 9.

Research Institute for Creating Future, Fuji Oil Holdings Inc., 1 Sumiyoshi, Izumisano, Osaka 598-8540, Japan.

Soy isoflavones (SIs) are abundant in soybeans and have inhibitory effects on contact hypersensitivity (CHS), which is often used as a mouse model for allergic contact dermatitis (ACD); however, their therapeutic mechanisms remain unknown. We studied the suppressive activity of dietary SI and gut microbiota on dinitrofluorobenzene (DNFB)-induced CHS. Low-dose SI diets alleviated DNFB-induced ear swelling and oedema and decreased infiltration of Gr-1-positive cells into ear tissue. Read More

Biol Pharm Bull 2018 ;41(10):1554-1560

Tokyo University of Technology Graduate School, Department of Bionics.

Sacran, a polysaccharide isolated from the alga Aphanothece sacrum (Suizenji-nori), has unique physical and physiological characteristics. In a previous study, we reported that sacran improves skin conditions in individuals who suffer from atopic dermatitis (AD), focusing on its trapping function against extrinsic stimuli compared with hyaluronic acid (HA). First, we examined the penetration of sacran through stratum corneum (SC) with an impaired barrier function using immature reconstructed human epidermal equivalents. Read More

Proc Natl Acad Sci U S A 2018 10 24;115(41):10404-10409. Epub 2018 Sep 24.

Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, 69365 Lyon Cedex 07, France;

Prominent changes in the gut microbiota (referred to as "dysbiosis") play a key role in the development of allergic disorders, but the underlying mechanisms remain unknown. Study of the delayed-type hypersensitivity (DTH) response in mice contributed to our knowledge of the pathophysiology of human allergic contact dermatitis. Here we report a negative regulatory role of the RIG-I-like receptor adaptor mitochondrial antiviral signaling (MAVS) on DTH by modulating gut bacterial ecology. Read More

Planta Med 2018 Sep 24. Epub 2018 Sep 24.

Freie Universitaet Berlin, Institute of Pharmacy, Department of Pharmaceutical Biology, Berlin, Germany.

In recent years, skin reactions such as phytophotodermatitis, contact dermatitis, and other inflammatory responses after contact with chemicals from various plants, e.g., or , are one of the hot topics in phytobiology. Read More

Int J Mol Sci 2018 Sep 7;19(9). Epub 2018 Sep 7.

Department of Immunology, Jagiellonian University Medical College, 31-121 Krakow, Poland.

Antibody light chains (LCs), formerly considered a waste product of immunoglobulin synthesis, are currently recognized as important players in the activation of the immune response. However, very little is known about the possible immune regulatory functions of LCs. Recently, we reported that hapten-specific LCs coat miRNA-150-carrying exosomes produced by CD8+ suppressor T cells downregulating the contact hypersensitivity (CHS) reaction in an antigen-specific manner, in mice tolerized by intravenous administration of a high dose of hapten-coupled syngeneic erythrocytes. Read More

Int J Mol Sci 2018 Sep 6;19(9). Epub 2018 Sep 6.

Laboratory of Experimental Immunology, IDI-IRCCS, 00167 Rome, Italy.

Human keratinocytes were recently shown to respond to anti-EGFR (epidermal growth factor receptor) drugs with activation of an interferon-κ-driven autocrine loop, leading to enhanced expression of innate antiviral effectors and of the pro-inflammatory chemokines CXCL10 (C-X-C motif chemokine 10) and CCL2 (C-C motif ligand 2). Here we showed active type I interferon signaling in the skin lesions of cancer patients undergoing treatment with the anti-EGFR drug cetuximab. Strong nuclear positivity for Interferon Regulatory Factor 1 and phosphorylated Signal Transducer and Activator of Transcription 1, enhanced interferon-κ expression and CXCL10 was associated to the epidermal compartment. Read More

Clin Exp Dermatol 2018 Sep 6. Epub 2018 Sep 6.

Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan.

Background: Tinea is an infectious disease by dermatophytes, of which Trichophyton species accounts for the overwhelming majority of case. Tinea often causes itching with inflammation. In terms of pruritus by fungal infection, however, tinea has not been investigated sufficiently to date. Read More

Exp Ther Med 2018 Sep 23;16(3):2763-2769. Epub 2018 Jul 23.

Department of Gerontology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430014, P.R. China.

Mast cells (MCs) have been reported to serve a crucial role in allergic diseases, including asthma, allergic rhinitis and anaphylaxis. A previous study revealed that microRNA-126 (miR-126) was associated with airway hyperresponsiveness induced by house dust mites, however the molecular mechanisms were unclear. The present study aimed to investigate the effect of miR-126 on immunoglobulin E (IgE)-regulated MC degranulation and explore its underlying mechanisms. Read More

Dermatitis 2018 Sep/Oct;29(5):282-284

From the University of Texas Southwestern Medical Center, Dallas.

Allergic contact dermatitis to metals has become increasingly recognized in patients with endovascular implants. The ACD can lead to in-stent restenosis as well as a prominent eczematous reaction overlying the implant, often necessitating its removal. We present a case of refractory allergic contact dermatitis to nickel in a 44-year-old man with numerous endovascular stents and vascular clips. Read More

Arch Toxicol 2018 Oct 10;92(10):3031-3050. Epub 2018 Aug 10.

Department of Forensic Sciences and Toxicology, University of Crete, Heraklion, Greece.

Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. One of the most frequent manifestations of chemical allergy is contact hypersensitivity, which can have serious impact on quality of life. Allergic contact dermatitis is a predominantly CD8 + T cell-mediated immune disease, resulting in erythema and eczema. Read More

Clin Immunol 2018 Oct 2;195:67-76. Epub 2018 Aug 2.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Radix Astragali, has long been used to alleviate allergic diseases (ADs). Formononetin is one of the major active components in Radix Astragali, but its mechanism on ADs is not definitively known. The fluorescein isothiocyanate isomer-induced atopic contact dermatitis mouse model and poly I:C or lipopolysaccharide-treated HaCaT cells were used to examine thymic stromal lymphopoietin (TSLP)/interleukin (IL)-33 production and expression of E-cadherin. Read More

Proc Natl Acad Sci U S A 2018 08 2;115(34):E8017-E8026. Epub 2018 Aug 2.

Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, Germany;

T cells critically depend on reprogramming of metabolic signatures to meet the bioenergetic demands during activation and clonal expansion. Here we identify the transcription factor Nur77 as a cell-intrinsic modulator of T cell activation. Nur77-deficient T cells are highly proliferative, and lack of Nur77 is associated with enhanced T cell activation and increased susceptibility for T cell-mediated inflammatory diseases, such as CNS autoimmunity, allergic contact dermatitis and collagen-induced arthritis. Read More

Nat Commun 2018 08 1;9(1):3020. Epub 2018 Aug 1.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Lymphotoxin-beta receptor (LTβR) signaling in lymphatic endothelial cells (LEC) regulates leukocyte afferent lymphatic transendothelial migration (TEM). The function of individual signaling pathways for different leukocyte subsets is currently unknown. Here, we show that LTβR signals predominantly via the constitutive and ligand-driven non-classical NIK pathway. Read More

Acta Dermatovenerol Croat 2017 Dec;25(4):312-313

lisa Moliterni, MD 2Sapienza University of Rome, Umberto I Polyclinic, Dermatology Department Viale del Policlinico 156 00186 Rome Italy

Hand eczema is a chronic disease (1), commonly considered the expression of a contact allergic or irritative dermatitis. However, when the prick/patch tests and laboratory investigations are negative, important diagnostic challenges may arise. Peripheral nerve fibers are in fact capable of releasing neuromediators. Read More

J Cosmet Sci 2018 May/Jun;69(3):213-228

Colgate-Palmolive Company, Piscataway, NJ (J.M.S., S.C., N.S., Z.N., L.P.).

Regular usage of cosmetic products and drugs in dermatological vehicles may cause irritant contact dermatitis. For example, aluminum chloride (AlCl), the most efficacious antiperspirant salt to treat hyperhidrosis, shows high irritancy potential. To mitigate the irritant contact dermatitis caused by topical application of products containing AlCl, we investigated the anti-irritating effects of aloe extract and taurine and . Read More

Toxicol In Vitro 2018 Oct 18;52:286-296. Epub 2018 Jul 18.

DOS in Biochemistry, University of Mysore, Manasagangothri, Mysuru 570 006, India; Department of Studies and Research in Biochemistry, Tumkur University, Tumakuru 572103, India. Electronic address:

Exposure of human population to industrial chemicals is believed as a significant contributing factor to the outgrowth of occupational diseases especially in developing countries due to improper safety measures and sanitary conditions. Para-tertiary butylcatechol (PTBC) widely employed in petrochemical, thermofax and phototypesetting industries, induces melanocytotoxicity and contact dermatitis leading to occupational leukoderma/vitiligo. Few vitiligo patients were reported for oxidative stress-induced hemolytic anemia and thrombocytopenia, however its impact on blood components is still not clear. Read More

J Cell Mol Med 2018 Sep 11;22(9):4507-4521. Epub 2018 Jul 11.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

Calycosin, a bioactive component derived from Astragali Radix (AR; Huang Qi), has been shown to have an effect of anti-allergic dermatitis with unknown mechanism. This study aims to investigate the mechanism of calycosin related to tight junctions (TJs) and HIF-1α both in FITC-induced mice allergic contact dermatitis and in IL-1β stimulated HaCaT keratinocytes. Th2 cytokines (IL-4, IL-5 and IL-13) were detected by ELISA. Read More

Clin Exp Allergy 2018 Oct 14;48(10):1333-1344. Epub 2018 Aug 14.

Laboratory of Molecular Immunology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Background: To recruit leucocytes to an inflammatory site, chemokine binding to glycosaminoglycans (GAGs) is critical. Therefore, strategies to interfere with this interaction, aiming at the production of anti-inflammatory agents, were developed. These include production of modified chemokines without affinity for G protein-coupled receptors but with enhanced affinity for GAGs. Read More

Acta Derm Venereol 2018 Oct;98(9):855-861

Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami, 1600 NW 10th Ave RMSB2063, Miami, FL 33136, USA.

Skin thermal changes modulate itch sensitivity. However, the mechanisms of this modulation are still unclear. Using mouse models of acute and chronic itch, we investigated whether local innocuous thermal stimulation of the skin alters itch sensitivity and if blockade of thermosensitive transient receptor potential (TRP) channels can reduce these changes. Read More

Pharmacol Rep 2018 Aug 23;70(4):796-803. Epub 2018 Feb 23.

Department of Medical Biology, Jagiellonian University College of Medicine, Kraków, Poland. Electronic address:

Background: Cyclophosphamide (CY) is one of the most widely used alkylating agents in the treatment of various cancers and some autoimmune diseases. Numerous reports suggest that CY exerts immunoregulatory effects. Animal studies have shown CY affects contact sensitivity (CS) response by depleting CD4CD25 T regulatory cells and CD8 T suppressor (Ts) cells. Read More

Front Immunol 2018 6;9:1279. Epub 2018 Jun 6.

Functional Proteome Analysis, German Cancer Research Center, Heidelberg, Germany.

The treatment of autoimmune diseases still poses a major challenge, frequently relying on non-specific immunosuppressive drugs. Current efforts aim at reestablishing self tolerance using immune cells with suppressive activity like the regulatory T cells (Treg) or the myeloid-derived suppressor cells (MDSC). We have demonstrated therapeutic efficacy of MDSC in mouse Alopecia Areata (AA). Read More

Dermatitis 2018 Jul/Aug;29(4):179-186

Dermatology, Duke University, Durham, NC.

Allergic contact dermatitis (ACD) is a common skin disease that results in significant cost and morbidity. Despite its high prevalence, therapeutic options are limited. Allergic contact dermatitis is regulated primarily by T cells within the adaptive immune system, but also by natural killer and innate lymphoid cells within the innate immune system. Read More

J Dermatol Sci 2018 Sep 12;91(3):292-300. Epub 2018 Jun 12.

Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea. Electronic address:

Background: (R)-(+)-pulegone (PLG), a biotransformation of monoterpene ketones, is one of essential oils of Labiatae family. Although PLG was reported to have anti-inflammatory and anti-histamine effects, the therapeutic effects of PLG on atopic dermatitis (AD) have not been reported yet.

Objective: This study investigated the anti-AD effects and underlying mechanisms of PLG in AD-induced mice. Read More

J Dermatol 2018 Sep 13;45(9):1117-1121. Epub 2018 Jun 13.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Lupus erythematosus profundus (LEP) is a variant of lupus erythematosus, involving the deep dermis and subcutaneous fat. LEP is characterized by the presence of lymphoid follicles (LF) and germinal centers (GC). However, it remains unknown whether these lymphoid structures correspond to the lymphoid tissues such as cutaneous tertiary lymphoid organs (TLO). Read More

Clin Rev Allergy Immunol 2019 Feb;56(1):19-31

Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Frauenlobstr. 9-11, 80337, Munich, Germany.

A wide variety of foods may cause or aggravate skin diseases such as contact dermatitis, contact urticaria, or atopic dermatitis (AD), both in occupational and private settings. The mechanism of action underlying allergic disease to food, food additives, and spices may be immunologic and non-immunologic. The classification and understanding of these reactions is a complex field, and knowledge of the possible reaction patterns and appropriate diagnostic test methods is essential. Read More

Biosci Biotechnol Biochem 2018 Sep 26;82(9):1531-1538. Epub 2018 May 26.

a Food Biotechnology Program , Korea University of Science and Technology , Republic of Korea.

Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by hapten-specific immune response. Silkworm droppings are known to exert beneficial effects during the treatment of inflammatory diseases. Here, we studied whether topical treatment and oral administration of silkworm dropping extract (SDE) ameliorate trimellitic anhydride (TMA)-induced ACD. Read More

Skin Therapy Lett 2018 05;23(3):5-9

Division of Dermatology, University of Calgary, Calgary, AB, Canada.

The class of medications known as Janus kinase inhibitors block cytokine-mediated signaling via the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, which plays an important role in immunoregulation and normal cell growth. This class includes the drugs tofacitinib, approved for the treatment of rheumatoid arthritis, and ruxolitinib, approved for the treatment of myelofibrosis and polycythemia rubra vera. The most common adverse events (AEs) reported in patients taking tofacitinib are infections, whereas the most common AEs in patients taking ruxolitinib are anemia and thrombocytopenia. Read More

Cell Death Dis 2018 05 1;9(5):548. Epub 2018 May 1.

The Biotherapy Center, the Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, 510630, Guangzhou, China.

Mesenchymal stromal cells (MSCs) have been demonstrated to ameliorate allergic contact dermatitis (ACD), a typical T-cell-mediated disorder. However, the underlying mechanisms behind the MSC-based treatment for ACD have not yet been fully elucidated. The stanniocalcins (STCs) comprise a family of secreted glycoprotein hormones that act as important anti-inflammatory proteins. Read More

An Bras Dermatol 2018 Mar;93(2):242-250

Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TNF, IL-1β, and IL-18, contributing to the development of Allergic Contact Dermatitis. Read More

Hautarzt 2018 Jun;69(6):443-448

Paul-Ehrlich-Institut, Langen, Deutschland.

Background: The food sector is one of the high-risk areas for occupational irritative and allergic contact eczema.

Objectives: The present work provides an overview of the main allergens as well as sensitization frequencies and risk in various food industry occupations.

Methods: The literature on type IV sensitization in the food sector is summarized. Read More

Theranostics 2018 23;8(9):2407-2423. Epub 2018 Mar 23.

Institute of Immunology, University of Münster, 48149 Münster, Germany.

Recruitment of leukocytes from the blood to sites of inflammation poses a promising target for new diagnostic and therapeutic approaches. We aimed to develop a novel method to non-invasively analyze molecular mechanisms of leukocyte migration in pre-clinical models of inflammation . We used the ER-HoxB8 system to transiently immortalize murine myeloid precursors from and CD18- as well as MRP14-deficient mice. Read More

Pharmacogn Mag 2018 Apr-Jun;14(54):174-179. Epub 2018 Apr 10.

Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, South Korea.

Background: Cabbage, var. capitata L., is one of the most common vegetables in the world. Read More

J Immunotoxicol 2018 12;15(1):82-89

a Henan Key Laboratory of Ecological Security and Collaborative Innovation Center of Water Security for Water Source Region of Mid-line of South-to-North Diversion, Project of Henan Province , College of Agricultural Engineering, Nanyang Normal University , Nanyang , China.

Skin sensitization is an important occupational health problem and immunotoxicity endpoint. Considering animal welfare and time and cost savings, many alternative approaches, such as those conducted in vitro, in silico, and in chemo, have been proposed and applied to predict skin sensitization of compounds. Toxicologically, sensitizers can elicit excess toxicity at greater levels than non-sensitizers due to their capacity to react with proteins/peptides. Read More

Int Arch Allergy Immunol 2018 18;176(2):91-100. Epub 2018 Apr 18.

Background: Although immunosuppressants for therapy of atopic dermatitis (AD) are still being sought, proteasome inhibitors are also potential candidates for the treatment of AD. Proteasome inhibitors exert various effects by blocking proteasomal degradation and help regulate processes such as apoptosis induction via caspase-9, cell cycle progression via cyclins, NF-κB inactivation via IκB, and downregulation of antigen cross-presentation. The cells targeted by proteasome inhibitors are therefore activated cells undergoing proliferation or differentiation, and antigen-presenting cells carrying out protein degradation. Read More

Int Immunopharmacol 2018 Jun 12;59:209-216. Epub 2018 Apr 12.

Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Atopic dermatitis (AD) is a common chronic inflammatory skin disorder afflicting from infancy to adults with itching, scratching, and lichenification. We aimed to investigate the effects of esculetin from Fraxinus rhynchophylla on atopic skin inflammation. For induction of atopic skin inflammation, we exposed the ears of female BALB/c mice to house dust mite (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) for 4 weeks. Read More