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    Rational Tuning of Visual Cycle Modulator Pharmacodynamics.
    J Pharmacol Exp Ther 2017 Jul 5;362(1):131-145. Epub 2017 May 5.
    Department of Pharmacology, School of Medicine (P.D.K., J.Z., K.P.), Department of Chemistry (M.B., G.P.T.), Case Western Reserve University, Cleveland, Ohio; Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (P.D.K., N.S.P.); Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio (J.K., N.S.P.); and Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio (N.S.P.)
    Modulators of the visual cycle have been developed for treatment of various retinal disorders. These agents were designed to inhibit retinoid isomerase [retinal pigment epithelium-specific 65 kDa protein (RPE65)], the rate-limiting enzyme of the visual cycle, based on the idea that attenuation of visual pigment regeneration could reduce formation of toxic retinal conjugates. Of these agents, certain ones that contain primary amine groups can also reversibly form retinaldehyde Schiff base adducts, which contributes to their retinal protective activity. Read More

    Protein tyrosine phosphatase conjugated with a novel transdermal delivery peptide, astrotactin 1-derived peptide recombinant protein tyrosine phosphatase (AP-rPTP), alleviates both atopic dermatitis-like and psoriasis-like dermatitis.
    J Allergy Clin Immunol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea; Research Institute for Natural Sciences, Hanyang University, Seoul, Korea; Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea. Electronic address:
    Background: Atopic dermatitis (AD) and psoriasis are the 2 most common chronic inflammatory skin diseases. There is an unmet medical need to overcome limitations for transcutaneous drug development posed by the skin barrier.

    Objective: We aimed to identify a novel transdermal delivery peptide and to develop a transcutaneously applicable immunomodulatory protein for treating AD and psoriasis. Read More

    Contact sensitizers trigger human CD1-autoreactive T-cell responses.
    Eur J Immunol 2017 Apr 25. Epub 2017 Apr 25.
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore.
    Allergic contact dermatitis is a primarily T-cell-mediated inflammatory skin disease induced by exposure to small molecular-weight haptens, which covalently bind to proteins. The abundance of cutaneous T cells that recognize CD1a antigen-presenting molecules raises the possibility that MHC-independent antigen presentation may be relevant in some hapten-driven immune responses. Here we examine the ability of contact sensitizers to influence CD1-restricted immunity. Read More

    Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model.
    Int J Mol Sci 2017 Mar 30;18(4). Epub 2017 Mar 30.
    College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungduk-gu, Cheongju 361-951, Korea.
    Centella asiatica has potent antioxidant and anti-inflammatory properties. However, its anti-dermatitic effect has not yet been reported. In this study, we investigated the anti-dermatitic effects of titrated extract of Centella asiatica (TECA) in a phthalic anhydride (PA)-induced atopic dermatitis (AD) animal model as well as in vitro model. Read More

    Skin sensitizers in cosmetics and beyond: potential multiple mechanisms of action and importance of T-cell assays for in vitro screening.
    Crit Rev Toxicol 2017 May 22;47(5):415-432. Epub 2017 Mar 22.
    a Cosmetics Division, Office of Cosmetics and Colors (OCAC) , Center for Food Safety and Applied Nutrition (CFSAN), Food and Drug Administration (FDA) , MD , USA.
    Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity (DTH) reaction induced by repeated contact with sensitizers. The ability of a chemical to act as a sensitizer has most frequently been tested in animals. As the use of animals for these purposes is gradually and globally being phased out, there is a need for reliable in vitro surrogate assays. Read More

    Roles of alternatively activated M2 macrophages in allergic contact dermatitis.
    Allergol Int 2017 Mar 17. Epub 2017 Mar 17.
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Alternatively activated macrophages (M2 macrophages) play key roles in the suppression of Th1 cell responses and the orchestration of tissue repair. However, recent studies have shown that M2 macrophages have potentials to produce high levels of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α, suggesting that M2 macrophages may exacerbate inflammation in some settings. In this regard, we have recently shown that large numbers of M2 macrophages accumulate in the sites of hapten-induced contact hypersensitivity (CHS), an animal model of allergic contact dermatitis, and that M2 macrophages exacerbate hapten-induced CHS by producing matrix metalloproteinase 12 (MMP12). Read More

    Mangiferin antagonizes TNF-α-mediated inflammatory reaction and protects against dermatitis in a mice model.
    Int Immunopharmacol 2017 Apr;45:174-179
    Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, PR China. Electronic address:
    This study aimed to investigate whether mangiferin played a protective role in a well-established dermatitis mouse model and tumor necrosis factor alpha (TNF-α)-induced RAW264.7 macrophages. Contact dermatitis is an inflammatory skin disease in the clinic, while its underlying mechanism still remains to be elucidated. Read More

    Occupational contact dermatitis from protein in sea products: who is the most affected, the fisherman or the chef?
    J Occup Med Toxicol 2017 10;12. Epub 2017 Feb 10.
    Service de dermato-vénéréologie CHRU Morvan, 2 avenue FOCH, Brest Cedex, 29609 France.
    Background: Protein contact dermatitis has frequently been reported in case studies (usually in cases involving contact with seafood products), but there are very few descriptive series. The objectives of this present study were firstly to determine the incidence of protein contact dermatitis among fishermen in France and compare it with data from onshore work involving seafood exposure. Second, to discover what factors could explain any differences. Read More

    Development of an in vitro method to estimate the sensitization induction level of contact allergens.
    Toxicol Lett 2017 Apr 9;271:1-11. Epub 2017 Feb 9.
    Laboratory of Toxicology, DiSFeB, Università degli Studi di Milano, Milan, Italy. Electronic address:
    No standardized in vitro methods to assess potency of skin sensitizers are available. Recently, we standardized a procedure which combines the epidermal equivalent potency assay with assessment of IL-18 to provide a single test for identification and classification of skin sensitizers. This current study aimed to extend tested chemicals, and to provide a simple in vitro method for estimation of the expected sensitization induction level interpolating in vitro EC50 and IL-18 SI2 values to predict LLNA EC3 and/or human NOEL from standards curves generated using reference contact allergens. Read More

    Tetradecanol reduces EL-4 T cell growth by the down regulation of NF-κB mediated IL-2 secretion.
    Eur J Pharmacol 2017 Mar 3;799:135-142. Epub 2017 Feb 3.
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea. Electronic address:
    Tetradecanol is a straight-chain saturated fatty alcohol purified from Dendropanax morbifera leaves. We found that tetradecanol (30μM) reduced specifically the growth of T cells such as EL-4 T cell and isolated murine CD4(+) T cells. In this study, we investigated the effects of tetradecanol on the regulation of interlukin-2 (IL-2), a potent T cell growth factor. Read More

    Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus.
    Parasit Vectors 2017 Jan 31;10(1):51. Epub 2017 Jan 31.
    Departament of Biochemistry and Immunology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, 14049-900, Brazil.
    Background: Ticks attach to and penetrate their hosts' skin and inactivate multiple components of host responses in order to acquire a blood meal. Infestation loads with the cattle tick, Rhipicephalus microplus, are heritable: some breeds carry high loads of reproductively successful ticks, whereas in others, few ticks feed and reproduce efficiently.

    Methods: In order to elucidate the mechanisms that result in the different outcomes of infestations with cattle ticks, we examined global gene expression and inflammation induced by tick bites in skins from one resistant and one susceptible breed of cattle that underwent primary infestations with larvae and nymphs of R. Read More

    Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression.
    BMC Complement Altern Med 2017 Jan 31;17(1):81. Epub 2017 Jan 31.
    Environnement and Health team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Safi, Morocco.
    Background: Several chronic inflammatory diseases are characterized by inappropriate CD4+ T cell response. In the present study, we assessed the ability of Capparis spinosa L. (CS) preparation to orientate, in vivo, the immune response mediated by CD4+ T cells towards an anti-inflammatory response. Read More

    Mouse Model of Hydroquinone Hypersensitivity via Innate and Acquired Immunity and its Promotion by Combined Reagents.
    J Invest Dermatol 2017 May 17;137(5):1082-1093. Epub 2017 Jan 17.
    Division of Molecular Regulation, Tohoku University Graduate School of Dentistry, Sendai, Japan.
    We established a mouse model of contact hypersensitivity (CHS) to hydroquinone (HQ), a widespread chemical in our environment. HQ was painted onto flanks; then, HQ was challenged by painting onto ear pinnas on days 7 and 14. The CHS after the second challenge was markedly greater than that after the first challenge. Read More

    Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway.
    Int J Mol Sci 2017 Jan 18;18(1). Epub 2017 Jan 18.
    Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
    Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. Read More

    Efficacy of a Film-Forming Medical Device Containing Piroxicam and Sun Filters in the Treatment of Multiple Actinic Keratosis Lesions in a Subject with a History of Kaposi Sarcoma.
    Case Rep Dermatol 2016 Sep-Dec;8(3):254-261. Epub 2016 Oct 4.
    Medical Department, Difa Cooper, IFC Group, Caronno Pertusella, Italy.
    Actinic keratosis (AK) is considered a premalignant form of skin cancer due to chronic sun exposure. In addition, human papilloma virus (HPV) has been advocated a role in the pathogenesis of this clinical condition. HPV proteins (mainly E6 and E7) seem to act synergistically with ultraviolet (UV) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after UV damage. Read More

    Reaction Chemistry to Characterize the Molecular Initiating Event in Skin Sensitization: A Journey to Be Continued.
    Chem Res Toxicol 2017 01 30;30(1):315-331. Epub 2016 Nov 30.
    Biosciences, Givaudan Schweiz AG , Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland.
    The publication by the OECD of the adverse outcome pathway (AOP) for skin sensitization has accelerated the development and validation of mechanistic tests and testing strategies to assess the potential of new molecules to trigger skin allergies. The molecular initiating event (MIE) in the AOP is reaction with skin peptides/proteins. It is followed by a number of cellular events. Read More

    Rubber: new allergens and preventive measures.
    Eur J Dermatol 2016 Dec;26(6):523-530
    Department of Occupational Diseases, Paris University Hospital, Centre Hôtel-Dieu, AP-HP 1, Parvis Notre-Dame, 75004 Paris, France.
    Natural rubber latex (NRL) and rubber accelerators are well-known causes of occupational skin diseases. The latest epidemiological data on rubber allergy show that rubber additives are still among the allergens most strongly associated with occupational contact dermatitis, however, a decrease in NRL allergy has been confirmed. A review of recent publications on rubber allergens based on the Pubmed database is presented. Read More

    Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF-α and ROS.
    J Biochem Mol Toxicol 2017 Mar 23;31(3). Epub 2016 Nov 23.
    Teaching & Research Section of Nuclear Medicine, Anhui Medical University, Hefei, Anhui, 230032, People's Republic of China.
    The skin-associated chemokine CCL27 and its receptor CCR10 mediate the immune response of skin-homing T cells. The CCL27 secreted from keratinocytes was reportedly involved in inflammatory skin diseases such as atopic dermatitis, contact dermatitis, and psoriasis. However, whether ionizing radiation increases the levels of CCL27 secretion still remains unclear. Read More

    Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
    Food Chem Toxicol 2017 Jan 18;99:60-69. Epub 2016 Nov 18.
    Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China. Electronic address:
    Diisodecyl phthalate (DIDP) is extensively used as an environmentally friendly plasticizer. However, little is known about the adverse effects and the underlying mechanisms of DIDP exposure on immunological diseases. We aimed to determine the role and mechanisms of DIDP exposure in allergic contact dermatitis-like skin lesions. Read More

    Tight junctions in skin inflammation.
    Pflugers Arch 2017 Jan 16;469(1):3-14. Epub 2016 Nov 16.
    Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
    Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e. Read More

    Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib.
    Eur J Pharmacol 2017 Jan 12;794:20-26. Epub 2016 Nov 12.
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, NC, USA. Electronic address:
    The janus kinase-inhibitor oclacitinib is licensed for the control of pruritus associated with allergic skin diseases in dogs. Strikingly, it has been clinically reported that abrupt withdrawal of oclacitinib leads to a rebound pruritus in dogs. Therefore, the primary objective of this study was to mimic the rebound phenomenon of oclacitinib using a chronic pruritic mouse model of allergic contact dermatitis. Read More

    Contact dermatitis and interferon-γ dependent chemokines.
    Clin Ter 2016 Sep-Oct;167(5):e112-e116
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Inflammation of the skin is the pathological base of contact dermatitis (CD), and cytokines are very important in its pathogenesis. Recently it has been shown that interferon (IFN)-γ, and the IFN-γ dependent chemokines, monokine induced by IFN-γ (MIG), IFN-γ-induced protein 10 (IP-10), and IFN-inducible T cell alpha chemoattractant (I-TAC), play an important role in CD. Allergic CD (ACD) is a T-cell-mediated disease in which expression of a distinct repertoire of chemokines results in the recruitment of effector T cells into the skin. Read More

    Inflammasomes and dermatology.
    An Bras Dermatol 2016 Sep-Oct;91(5):566-578
    Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
    Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the absence of autoantigens and autoantibodies. Read More

    Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.
    J Clin Invest 2016 Dec 7;126(12):4497-4515. Epub 2016 Nov 7.
    Epidermal keratinocytes form a structural and immune barrier that is essential for skin homeostasis. However, the mechanisms that regulate epidermal barrier function are incompletely understood. Here we have found that keratinocyte-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic phenotype. Read More

    Proteomics analysis of dendritic cell activation by contact allergens reveals possible biomarkers regulated by Nrf2.
    Toxicol Appl Pharmacol 2016 Dec 3;313:170-179. Epub 2016 Nov 3.
    German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany.
    Allergic contact dermatitis is a widespread disease with high clinical relevance affecting approximately 20% of the general population. Typically, contact allergens are low molecular weight electrophilic compounds which can activate the Keap1/Nrf2 pathway. We performed a proteomics study to reveal possible biomarkers for dendritic cell (DC) activation by contact allergens and to further elucidate the role of Keap1/Nrf2 signaling in this process. Read More

    Preliminary analysis of Psoroptes ovis transcriptome in different developmental stages.
    Parasit Vectors 2016 Nov 4;9(1):570. Epub 2016 Nov 4.
    Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
    Background: Psoroptic mange is a chronic, refractory, contagious and infectious disease mainly caused by the mange mite Psoroptes ovis, which can infect horses, sheep, buffaloes, rabbits, other domestic animals, deer, wild camels, foxes, minks, lemurs, alpacas, elks and other wild animals. Features of the disease include intense pruritus and dermatitis, depilation and hyperkeratosis, which ultimately result in emaciation or death caused by secondary bacterial infections. The infestation is usually transmitted by close contact between animals. Read More

    In vivo skin penetration of macromolecules in irritant contact dermatitis.
    Int J Pharm 2016 Dec 19;515(1-2):384-389. Epub 2016 Oct 19.
    Institute of Pharmaceutical Technology, Pharmacy institutes, University of Bonn, Bonn, Germany; FDE (EA4267), university of Bourgogne Franche-Comté, Besançon, France.
    Recently, a selective preferential accumulation of polymeric nanoparticles (in the size range around 100nm) has been observed in the follicular system of dermatitis skin. The present investigation aimed at clearly investigating the effect of irritant contact dermatitis on the barrier permeability for colloidal systems below this size range, namely quantum dots and hydrophilic macromolecules. Irritant dermatitis was induced in mice and the penetrability of quantum dots (5nm) and hydrophilic dextran molecules has been tracked in both healthy and inflamed skin using confocal laser scanning microscopy. Read More

    c-CBL E3 Ubiquitin Ligase Expression Increases Across the Spectrum of Benign and Malignant T-Cell Skin Diseases.
    Am J Dermatopathol 2016 Oct 31. Epub 2016 Oct 31.
    *Department of Dermatology, University of Wisconsin, Madison, WI; and †Department of Dermatology, William S. Middleton VA Medical Center, Madison, WI.
    Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Read More

    The adverse outcome pathway for skin sensitisation: Moving closer to replacing animal testing.
    Altern Lab Anim 2016 Oct;44(5):453-460
    Laboratory of Mathematical Chemistry (LMC), As. Zlatarov University, Bourgas, Bulgaria.
    This article outlines the work of the Organisation for Economic Co-operation and Development (OECD) that led to being jointly awarded the 2015 Lush Black Box Prize. The award-winning work centred on the development of 'The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins'. This Adverse Outcome Pathway (AOP) has provided the mechanistic basis for the integration of skin sensitisation-related information. Read More

    The use of peptide reactivity assays for skin sensitisation hazard identification and risk assessment.
    Altern Lab Anim 2016 Oct;44(5):437-442
    The Procter & Gamble Company, Mason Business Center, Cincinnati, OH, USA.
    Over the past 20 years or more, investigators have been developing non-animal test methods for use in assessing the skin sensitisation potential of chemicals. In parallel with this effort, the key biological events of skin sensitisation have been well-characterised in an Adverse Outcome Pathway (AOP) proposed by the Organisation for Economic Co-operation and Development (OECD). The key molecular initiating event of this AOP is haptenation or covalent modification of epidermal proteins. Read More

    Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.
    Eur J Pharmacol 2016 Nov 5;791:669-674. Epub 2016 Oct 5.
    Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy; Endocannabinoid Research Group, Italy.
    In mice, 2,4-dinitrofluorobenzene (DNFB) induces contact allergic dermatitis (CAD), which, in a late phase, is characterized by mast cell (MC) infiltration and angiogenesis. Palmitoylethanolamide (PEA), an endogenous anti-inflammatory molecule, acts by down-modulating MCs following activation of the cannabinoid CB2 receptor and peroxisome proliferator-activated receptor-α (PPAR-α). We have previously reported the anti-inflammatory effect of PEA in the early stage of CAD. Read More

    Protein content of the Hylesia metabus egg nest setae (Cramer [1775]) (Lepidoptera: Saturniidae) and its association with the parental investment for the reproductive success and lepidopterism.
    J Proteomics 2017 Jan 25;150:183-200. Epub 2016 Aug 25.
    Mass Spectrometry Laboratory and GlycoLab, Department of Proteomics, Center for Genetic Engineering and Biotechnology, PO Box 6162, Havana, Cuba. Electronic address:
    Hylesia metabus is a neotropical moth possessing toxic setae, which once in contact with the skin cause a severe dermatitis to humans known as lepidopterism. The only known function of the setae in the life cycle is to provide protection during the mating and egg-hatching stages. Approximately 65% of the protein content of the setae is a cluster of five proteases (28-45kDa) showing sequence homology to other S1A serine proteases. Read More

    Long-term clinical safety and efficacy of brodalumab in the treatment of Japanese patients with moderate-to-severe plaque psoriasis.
    J Eur Acad Dermatol Venereol 2016 Nov 29;30(11):1957-1960. Epub 2016 Jun 29.
    Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan.
    Background: Brodalumab (KHK4827) is a human anti-interleukin-17-receptor A monoclonal antibody. In Japanese patients with moderate-to-severe plaque psoriasis, brodalumab showed rapid and robust efficacy and a favourable safety profile in a 12-week, phase 2, double-blind, randomized controlled trial.

    Objectives: To evaluate the long-term safety and efficacy of brodalumab, an extension of a phase 2 trial of Japanese patients with moderate-to-severe psoriasis was performed. Read More

    An individual approach to feline diabetes care: a case report and literature review.
    Acta Vet Scand 2016 Oct 20;58(Suppl 1):63. Epub 2016 Oct 20.
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, North Mymms, Hertfordshire, UK.
    Background: Achieving insulin independence is emerging as a realistic therapeutic goal in the management of feline diabetes mellitus.

    Case Presentation: The management of an 11-year-old spayed female Burmese cat presenting with diabetes mellitus after corticosteroid administration is described. Remission was achieved after the frequency of insulin administration was increased to four times a day, and supported by intensive home blood glucose monitoring and a high protein, low carbohydrate diet. Read More

    Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis.
    Arch Dermatol Res 2016 Dec 5;308(10):711-721. Epub 2016 Oct 5.
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
    In this study, we topically administered two antioxidant compounds, the manganese-porphyrin-derivatives BMX-001 and BMX-010, in a mouse model of allergic dermatitis and compared the efficacy for reduction of itch and inflammation. In vitro effects of BMX-001 and BMX-010 on keratinocytes, bone marrow derived dendritic cells (BMDCs) and T-cells were initially analysed. For assessment of scratching behaviour, BMX-001 and BMX-010 (0. Read More

    Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.
    J Leukoc Biol 2017 Mar 5;101(3):703-715. Epub 2016 Oct 5.
    UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France; and
    Allergic contact dermatitis (ACD) represents a severe health problem with increasing worldwide prevalence. It is a T-cell-mediated inflammatory skin disease caused by chemicals present in the daily or professional environment. NiSO4 and 2,4-dinitrochlorobenzene (DNCB) are 2 chemicals involved in ACD. Read More

    A proteomic approach for the identification of immunotoxic properties of Tulipalin A.
    Proteomics 2016 Dec 15;16(23):2997-3008. Epub 2016 Nov 15.
    Institute of Pharmacy, Pharmaceutical Biology, Ernst-Moritz-Arndt-University, Greifswald, Germany.
    The immune system is permanently exposed to several environmental influences that can have adverse effects on immune cells or organs leading to immunosuppression or inappropriate immunostimulation, called direct immunotoxicity. The natural compound Tulipalin A (TUPA), a lactone with α-methylene-γ-butyrolactone moiety, can influence the immune system and lead to allergic contact dermatitis. This in vitro study focused on effects of TUPA using two immune cell lines (Jurkat T cells and THP-1 monocytes). Read More

    Inhibitory effects of dietary soyasaponin on 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice.
    Exp Dermatol 2017 Mar 2;26(3):249-254. Epub 2017 Feb 2.
    Department of Applied Molecular Bioscience, Nagoya University, Aichi, Japan.
    Soyasaponins (SSs) abundant in soybean have anti-inflammatory activities; however, their therapeutic effects on allergic contact dermatitis (ACD) remain unknown. To assess the effects of SS-enriched diets on ACD, we used a mouse model of contact hypersensitivity (CHS). Mice were fed low-dose or high-dose SS-containing diets for 3 weeks prior to CHS induction with 2,4-dinitrofluorobenzene (DNFB). Read More

    Proposed ICDRG Classification of the Clinical Presentation of Contact Allergy.
    Dermatitis 2016 Sep-Oct;27(5):248-58
    From the *Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; †Allergy Center and Department of Dermatology, University Hospital, Republic University of Uruguay, Montevideo; ‡Department of Dermatology and Allergy Center, Center for Innovative Medical Technology, Institute of Clinical Research, University of Southern Denmark, Odense; §Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden; ∥Department of Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Germany; ¶Department of Dermatology, University Hospital Jena, Germany; #Department of Dermatology, National Skin Centre, Singapore; **Contact Allergy Unit, Department of Dermatology, University Hospital KU Leuven, Belgium; ††MGM Medical College, Kamothe, Mumbai, India; ‡‡Department of Dermatology, Catholic University of Louvain, Brussels, Belgium; §§Department of Dermatology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul; ∥∥Department of Dermatology, UCSF School of Medicine, San Francisco, CA; ¶¶Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ##Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation, Melbourne, Victoria, Australia; ***Institute of Dermatology, Bangkok, Thailand; †††Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal General Hospital, Quebec, Canada; ‡‡‡Dermatologic Department, Division of Medicine, Phramongkutklao Hospital, Bangkok, Thailand; and §§§Department of Cutaneous Allergy, St. John's Institute of Dermatology, King's College, Guy's Hospital, London, United Kingdom.
    The International Contact Dermatitis Research Group proposes a classification for the clinical presentation of contact allergy. The classification is based primarily on the mode of clinical presentation. The categories are direct exposure/contact dermatitis, mimicking or exacerbation of preexisting eczema, multifactorial dermatitis including allergic contact dermatitis, by proxy, mimicking angioedema, airborne contact dermatitis, photo-induced contact dermatitis, systemic contact dermatitis, noneczematous contact dermatitis, contact urticaria, protein contact dermatitis, respiratory/mucosal symptoms, oral contact dermatitis, erythroderma/exfoliative dermatitis, minor forms of presentation, and extracutaneous manifestations. Read More

    Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.
    BMC Complement Altern Med 2016 Sep 6;16:347. Epub 2016 Sep 6.
    Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea.
    Background: Sanguisorbae Radix (SR) is a well-known herbal medicine used to treat inflammatory disease and skin burns in Asia. In addition, it is used to treat many types of allergic skin diseases, including urticaria, eczema, and allergic dermatitis. SR has been reported to exhibit anti-wrinkle, anti-oxidant, and anti-contact dermatitis bioactivities. Read More

    Cosmetic components causing contact urticaria: a review and update.
    Contact Dermatitis 2016 Dec 4;75(6):333-344. Epub 2016 Sep 4.
    Department of Dermatology, University Hospitals KU Leuven, Leuven, 3000, Belgium.
    Immediate skin reactions are common in dermatological practice, but may often be overlooked. The main objective of this article is to provide an update of the literature concerning immediate-type reactions or contact urticaria/contact urticaria syndrome caused by cosmetic ingredients in terms of immediate clinical symptoms, positive reactions following open, scratch or, most often, prick testing, and sometimes the detection of specific IgE antibodies. To this end, a selective search in different medical literature databases was performed. Read More

    Herpetol ameliorates allergic contact dermatitis through regulating T-lymphocytes.
    Int Immunopharmacol 2016 Nov 31;40:131-138. Epub 2016 Aug 31.
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. Electronic address:
    An immunosuppressant with fewer adverse effects is still urgently needed for increasing numbers of patients suffering from allergic contact dermatitis. In the present study, we aimed to investigate the immunosuppressive activity of herpetol on T-lymphocytes in vitro and in vivo and explore its potential pharmacological mechanism. The results showed that herpetol could effectively inhibit the proliferation of activated T cells and reduce the production of pro-inflammatory cytokines at 5-20μM. Read More

    Histamine Modulates Sweating and Affects Clinical Manifestations of Atopic Dermatitis.
    Curr Probl Dermatol 2016 30;51:50-6. Epub 2016 Aug 30.
    Many factors such as food or environmental allergens, bacteria, fungi, and mental stress aggravate the condition of atopic dermatitis (AD) eczema. Sweating can also exacerbate AD, and patients are aware of that. In the past, it has been reported that contamination of skin surface antigens by sweat induces acute allergic reactions and that sweating functions of AD patients via axonal reflexes are decreased. Read More

    6-Shogaol, an active compound of ginger, alleviates allergic dermatitis-like skin lesions via cytokine inhibition by activating the Nrf2 pathway.
    Toxicol Appl Pharmacol 2016 Nov 22;310:51-59. Epub 2016 Aug 22.
    Department of Pharmaceutical Engineering, College of Biomedical Science, Daegu Haany University, Republic of Korea. Electronic address:
    Allergic dermatitis (AD) clinically presents with skin erythematous plaques, eruption, and elevated serum IgE, and T helper cell type 2 and 1 (Th2 and Th1) cytokine levels. 6-Shogaol [1-(4-hydroxy-methoxyphenyl)-4-decen-one], a pungent compound isolated from ginger, has shown anti-inflammatory effects, but its inhibitory effects on AD are unknown. The aim of this study was to examine whether 6-shogaol inhibits AD-like skin lesions and their underlying mechanism in vivo and in vitro. Read More

    CD1a on Langerhans cells controls inflammatory skin disease.
    Nat Immunol 2016 Oct 22;17(10):1159-66. Epub 2016 Aug 22.
    Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
    CD1a is a lipid-presenting molecule that is abundantly expressed on Langerhans cells. However, the in vivo role of CD1a has remained unclear, principally because CD1a is lacking in mice. Through the use of mice with transgenic expression of CD1a, we found that the plant-derived lipid urushiol triggered CD1a-dependent skin inflammation driven by CD4(+) helper T cells that produced the cytokines IL-17 and IL-22 (TH17 cells). Read More

    Allergy Testing.
    Prim Care 2016 Sep;43(3):363-74
    Department of Family Medicine, University of Pittsburgh Medical Center (UPMC) McKeesport Family Medicine Residency, 2347 Fifth Avenue, McKeesport, PA 15132, USA. Electronic address:
    Allergic diseases are common in outpatient primary care. Allergy testing can guide management to determine allergy as a cause of symptoms and target therapeutic interventions. This article provides a review of common methods of allergy testing available so that physicians may counsel and refer patients appropriately. Read More

    Neurotensin-based hybrid peptide's anti-inflammatory activity in murine model of a contact sensitivity response.
    Eur J Pharm Sci 2016 Oct 7;93:84-9. Epub 2016 Aug 7.
    Department of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, Poland.
    The objective of the study was to investigate the possibility of modulation of skin inflammation by topical treatment with a novel compound: an opioid-neurotensin hybrid peptide PK20 encompassing endomorphin-2 analog and modified fragment of neurotensin (8-13). Contact sensitivity response was induced in mice by skin sensitization with dinitrofluorobenzene (DNFB) followed by topical hapten application on ears. Mice were treated locally with PK20 or pure cream 2h after the challenge with DNFB. Read More

    The 'omics' revolution: redefining the understanding and treatment of allergic skin diseases.
    Curr Opin Allergy Clin Immunol 2016 Oct;16(5):469-76
    aDepartment of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA bDepartment of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel cLaboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA *Margeaux Oliva and Yael Renert-Yuval contributed equally to the article.
    Purpose Of Review: To evaluate how the genomic, transcriptomic, and proteomic profiles of allergic skin diseases, like atopic dermatitis and allergic contact dermatitis, contribute to their understanding and promote their therapeutic development.

    Recent Findings: The '-omics' revolution has facilitated the quantification of inflammatory skin diseases at the molecular level, expanding our understanding of disease pathogenesis. It has also greatly expanded once-limited treatment options and improved the ability to define posttreatment improvements, beyond clinical scores. Read More

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