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Mol Biol Rep 2022 Jun 22. Epub 2022 Jun 22.

Faculty of Sciences, Department of Biology, Biotechnology Division, Istanbul University, 34452, Istanbul, Turkey.

Background: Hyperpigmentation, which causes excessive melanin synthesis and accumulation, is an important issue in the cosmetic industry. Since compounds developed against hyperpigmentation often come with side effects such as skin irritation and contact dermatitis, new studies focus on the use of natural agents that have no side effects.

Methods And Results: In this study, it was found that the effects of soybean cell culture extract (SCE) on alpha-melanocyte-stimulating hormone (α-MSH) induced melanogenesis in B16-F10 murine melanoma cells. Read More

Cytokine 2022 Aug 6;156:155897. Epub 2022 Jun 6.

Immunology Discovery, Janssen Research and Development, San Diego, CA 92121, USA. Electronic address:

The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric receptor composed of IL-36R and the IL-1R accessory protein (IL-1RAcP). Individuals with inactivating mutations in the gene encoding IL-36Ra develop generalized pustular psoriasis, a severe form of psoriasis, a finding which clearly links dysregulated IL-36 pathway activation to inflammatory skin conditions. The purpose of this review is to highlight the cellular source of IL-36 cytokines, the effects of IL-36 signaling across cell types, and the association of IL-36 to a spectrum of inflammatory skin diseases including various forms of psoriasis as well as hidradenitis suppurativa, atopic dermatitis, and allergic contact dermatitis. Read More

Theranostics 2022 1;12(8):3610-3627. Epub 2022 May 1.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.

The development of activatable photosensitizers (aPSs) responding to tumor-specific biomarkers for precision photodynamic therapy (PDT) is urgently required. Due to the unique proteolytic activity and highly restricted distribution of tumor-specific enzymes, enzyme activatable photosensitizers display superior selectivity. Herein, a series of novel Fibroblast Activation Protein α (FAPα) activatable theranostic pro-photosensitizers were designed by conjugating the different -terminal blocked FAPα-sensitive dipeptide substrates with a clinical PS, methylene blue (MB), through a self-immolative linker, which resulting in the annihilation of the photoactivity (fluorescence and phototoxicity). Read More

Cutis 2022 03;109(3):158-159

Department of Dermatology, Northwestern University Feinberg School of Medicine and Medical Dermatology Associates of Chicago, both in Chicago, Illinois.

Front Immunol 2022 12;13:898419. Epub 2022 May 12.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Skin is a frontline organ that is continuously exposed to external stimuli, including pathogens. Various immune cells reside in the skin under physiological conditions and protect the body from the entry of pathogens/antigens by interacting with each other and orchestrating diverse cutaneous immune responses. To avoid unnecessary inflammation and tissue damage during the elimination of external pathogens and antigens, skin possesses regulatory systems that fine-tune these immune reactions. Read More

Cells 2022 05 19;11(10). Epub 2022 May 19.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata, Chunilal Bhawan, 168 Maniktala Main Road, Kolkata 700054, West Bengal, India.

Atopic dermatitis (AD), characterized by rashes, itching, and pruritus, is a chronic inflammatory condition of the skin with a marked infiltration of inflammatory cells into the lesion. It usually commences in early childhood and coexists with other atopic diseases such as allergic rhinitis, bronchial asthma, allergic conjunctivitis, etc. With a prevalence rate of 1-20% in adults and children worldwide, AD is gradually becoming a major health concern. Read More

Turk J Pediatr 2022 ;64(2):389-393

Division of Pediatric Allergy & Immunology, Near East University, Faculty of Medicine, Nicosia, North Cyprus.

Background: Thaumetopoea Pityocampa (TP) are frequent in the Mediterranean region especially affecting forest workers in pinewood areas. The common symptoms include swelling, rash or burns like any form of dermatitis. The reactions can be triggered by mechanical, chemical or allergic factors and the `allergic` reaction is caused by sensitization to a hair protein named `thaumetopoein`. Read More

Front Immunol 2022 28;13:883116. Epub 2022 Apr 28.

Department of Basic Medicine, Medical College, Shaoxing University, Shaoxing, China.

Thioredoxin-1 (Trx1) is an important regulator of cellular redox homeostasis that comprises a redox-active dithiol. Trx1 is induced in response to various stress conditions, such as oxidative damage, infection or inflammation, metabolic dysfunction, irradiation, and chemical exposure. It has shown excellent anti-inflammatory and immunomodulatory effects in the treatment of various human inflammatory disorders in animal models. Read More

Adv Exp Med Biol 2022 ;1365:75-95

Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa, Japan.

The recent discovery of new innate lymphoid cells (ILCs) has revolutionized the field of allergies. Since most allergic diseases induce a type 2 immune response, Th2 cells, which produce IL-4, IL-5, and IL-13 in an antigen-dependent manner, in addition to basophils and mast cells which are activated by antigen-specific IgE, are thought to play a major role in the pathogenesis. However, since group 2 innate lymphoid cells (ILC2s) produce type 2 cytokines (i. Read More

Contact Dermatitis 2022 May 7. Epub 2022 May 7.

Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

Front Toxicol 2022 6;4:856614. Epub 2022 Apr 6.

Department of Environmental Science, Stockholm University, Stockholm, Sweden.

The immunological response in contact hypersensitivity is incited by small electrophilic compounds, known as haptens, that react with endogenous proteins after skin absorption. However, the identity of hapten-modified proteins seen as immunogenic remains as yet largely unknown. In a recent study, we have for the first time identified a hapten-modified protein in the local lymph nodes of mice treated topically with the model hapten tetramethylrhodamine isothiocyanate (TRITC). Read More

Comput Math Methods Med 2022 9;2022:9222541. Epub 2022 Apr 9.

Department of Biological Science, College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319 Heilongjiang Province, China.

Background: Allergic contact dermatitis (ACD) is a form of chronic cutaneous inflammatory disease of immunological origin that has adverse impacts on patient quality of life, underscoring the need for the development of safe and effective therapeutic agents to treat affected individuals. Fisetin is a Chinese herbal preparation that reportedly exhibits antitumor, antioxidant, antimicrobial, anticoagulatory, and antimalarial activity. In the current report, the immunomodulatory activity of fisetin was appraised by assessing its impact on balance between regulatory T (Treg) and Th17 cells in an ACD model. Read More

J Immunotoxicol 2022 12;19(1):27-33

Safety Science Research Laboratories, Kao Corporation, Tochigi, Japan.

Epicutaneous exposure to protein allergens, such as papain, house dust mite (HDM), and ovalbumin (OVA), represents an important mode of sensitization for skin diseases including protein contact dermatitis, immunologic contact urticaria, and atopic dermatitis. These diseases are inducible by re-exposure to an allergen at both original skin sensitization and distant skin sites. In this study, we examined the serum IgE/IgG response, differentiation of T-helper (T) cells, and epicutaneous T recall response in mice pre-sensitized with protein allergens through the back skin and subsequently challenged on the ear skin. Read More

Front Toxicol 2022 18;4:851017. Epub 2022 Mar 18.

Université Paris-Saclay, Inserm, Inflammation, Microbiome and Immunosurveillance, Châtenay-Malabry, France.

Allergic contact dermatitis (ACD) is a complex skin pathology occurring in reaction against environmental substances found in the workplace (cement, hair dyes, textile dyes), in the private environment (e.g., household products, cosmetic ingredients), or following skin exposure to drugs. Read More

Front Mol Biosci 2022 10;9:828674. Epub 2022 Mar 10.

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.

Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel. Toxicity caused by dermal and respiratory exposures of the general population to nickel-containing objects and particles is a deleterious side effect of modern technologies. Its molecular mechanism may include the peptide bond hydrolysis in X-S/T-c/p-H-c-X motifs by released Ni ions. Read More

J Vis Exp 2022 03 10(181). Epub 2022 Mar 10.

Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University.

Parallel to traditional Th1/Th2/Th17/Treg lineages, granulocyte-macrophage colony-stimulating factor-producing T helper (Th-GM) cells have been identified as a distinct subset of T helper cells (GM-CSF IFN-γ IL-17A IL-22 effector CD4 T cells) in human and mice. Contact hypersensitivity (CHS) is considered an excellent animal model for allergic contact dermatitis (ACD) in human, manifesting an intact T cell-mediated immune response. To provide a standardized and comprehensive assay to analyze the Th-GM cell subset in the T cell-dependent immune response in vivo, a murine CHS model was induced by sensitization/challenge with a reactive, low-molecular-weight, organic hapten, 2,4-dinitrofluorobenzene (DNFB). Read More

Acta Trop 2022 Jul 23;231:106428. Epub 2022 Mar 23.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto Nacional de Medicina Tropical (INMeT) - ANLIS "Dr. Carlos G Malbrán", Almafuerte y Ámbar s/n, 3370 Puerto, Iguazú, Argentina. Electronic address:

The saturniid genus Hylesia is well known for the cutaneous lepidopterism induced by airborne setae on contact with the skin. Although several cases of such dermatitis have been reported in Argentina, no information about their venoms and toxicological implications on human health is available yet. Thus, we conducted a morphological analysis of the setae/spines and a toxinological characterization (through biological assays and proteomic techniques) of the bristle extract from caterpillars and moths of Hylesia sp. Read More

APMIS 2022 Jun 6;130(6):314-322. Epub 2022 Apr 6.

The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Interleukin-22 (IL-22) is a cytokine mainly produced by T cells and innate lymphoid cells (ILC). IL-22 primarily targets non-hematopoietic cells such as epithelial cells and fibroblasts. In the skin, IL-22 promotes the proliferation of keratinocytes and dermal fibroblasts. Read More

Int J Biol Macromol 2022 Apr 4;205:703-718. Epub 2022 Mar 4.

Department of Forest Biomaterials, College of Natural Resources, North Carolina State University, Raleigh, NC 27607, USA; Bioproducts Institute, Department of Chemical & Biological Engineering, 2360 East Mall, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Current research targets innovative medical textiles of nanofibrous nature and antibacterial activity to prevent diaper dermatitis. The work is based on electrospun nanofibers from cellulose acetate (CA) and lignin (Lig) polymers. A series of new copper complexes were synthesized and loaded to the CA/Lig solution mix then subjected to electrospinning, giving rise to the tricomponent bioactive mats CA/Lig/Cu-complex. Read More

Sci Rep 2022 03 2;12(1):3434. Epub 2022 Mar 2.

Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.

Rucaparib (RCP) is a potent selective inhibitor of both PARP-1 and PARP-2 enzymes that induces synthetic lethality in cancer cells. It is used for the treatment of breast and ovarian tumors harboring deleterious germline or somatic cancer susceptibility genes mutations. Although RCP has an indole chromophore in its structure, it displays a bathochromic shift of the absorption band towards the UVA region of sunlight, thus extending the active fraction of solar light able to produce photosensitivity reactions. Read More

Contact Dermatitis 2022 Jul 18;87(1):28-39. Epub 2022 Mar 18.

Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA.

Background: Obesity is associated with chronic, low-grade inflammation in tissues and predisposes to various complications, including inflammatory skin diseases. However, the link between obesity and contact hypersensitivity (CHS) is not fully understood.

Objectives: We sought to determine the influence of obesity on T helper 1 (Th1)-mediated CHS. Read More

Pharmaceuticals (Basel) 2022 Feb 9;15(2). Epub 2022 Feb 9.

Research Institute for Medicines (iMed.ULisboa), Universidade de Lisboa, 1649-003 Lisbon, Portugal.

The use of natural products in dermatology is increasingly being pursued due to sustainability and ecological issues, and as a possible way to improve the therapeutic outcome of chronic skin diseases, relieving the burden for both patients and healthcare systems. The legalization of cannabis by a growing number of countries has opened the way for researching the use of cannabinoids in therapeutic topical formulations. Cannabinoids are a diverse class of pharmacologically active compounds produced by (phytocannabinoids) and similar molecules (endocannabinoids, synthetic cannabinoids). Read More

J Immunol 2022 03 23;208(6):1424-1433. Epub 2022 Feb 23.

Immunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China;

NF-erythroid 2-related factor 2 (Nrf2) is a major transcription factor to protect cells against reactive oxygen species (ROS) and reactive toxicants. Meanwhile, Nrf2 can inhibit contact dermatitis through redox-dependent and -independent pathways. However, the underlying mechanisms of how Nrf2 mediates irritant contact dermatitis (ICD) are still unclear. Read More

Nat Biotechnol 2022 Jun 21;40(6):965-973. Epub 2022 Feb 21.

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

High-redox-potential reactive oxygen species and reactive nitrogen species (ROS/RNS), generated by NADPH oxidase-2 (NOX2), myeloperoxidase (MPO) and related enzymes, are key effector molecules of innate immunity. High-redox-potential radicals are difficult to distinguish by imaging from less potent ROS/RNS functioning as background biological signaling molecules. Here we present 4-[F]fluoro-1-naphthol ([F]4FN), a redox-tuned radiopharmaceutical that selectively binds proteins and cells when oxidized by products of human MPO plus HO, but not HO alone, and can be detected using positron emission tomography (PET). Read More

Clin Dermatol 2022 Mar-Apr;40(2):145-149. Epub 2021 Oct 27.

Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut, USA. Electronic address:

There is a worldwide increase in food and nutrition-related contact dermatitis, including irritant contact dermatitis, allergic contact dermatitis, systemic contact dermatitis, protein contact dermatitis, and photocontact dermatitis. A wide range of patients is affected by this condition, from those who consume certain foods as part of their diet to workers who handle food occupationally. Patch testing, analytical chemistry, and reporting may help in timely recognition of contact allergens. Read More

Front Immunol 2022 1;13:764793. Epub 2022 Feb 1.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity response to skin contact allergens in which keratinocytes are critical in the initiation of early responses. Keratin 17 (K17) is a cytoskeletal protein inducible under stressful conditions and regulates multiple cellular processes, especially in skin inflammatory diseases; however, knowledge regarding its contribution to ACD pathogenesis remains ill defined. In the present study, we clarified the proinflammatory role of K17 in an oxazolone (OXA)-induced contact hypersensitivity (CHS) murine model and identified the underlying molecular mechanisms. Read More

J Dermatol 2022 May 17;49(5):519-524. Epub 2022 Feb 17.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Rosacea is a chronic inflammatory skin disease with facial redness and acne-like papules and pustules. The characteristics and background of rosacea patients in Japan have not been well documented. In this study, we retrospectively collected the medical information of rosacea patients, and investigated the background, complications, exacerbating factors, and status of allergy. Read More

Crit Rev Toxicol 2021 11 15;51(10):805-819. Epub 2022 Feb 15.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, England, UK.

It is widely recognized that the ability of chemicals to sensitize, and the potency of those chemicals that are sensitizers, is related to their ability to covalently modify protein in the skin. With the object of putting non-animal-based prediction of skin sensitization on a more quantitative footing, a recent paper describes the development of the kinetic Direct Protein Reactivity Assay (kDPRA), in which a matrix of peptide depletion values for different reaction times and test chemical concentrations is generated and analyzed so as to derive a reactivity parameter, log, which is used to classify chemicals into one of two potency categories. The present paper demonstrates that the reaction chemistry is not always consistent with the mathematical analysis of the data matrix and the kDPRA protocol does not identify such cases. Read More

Contact Dermatitis 2022 Jul 2;87(1):13-19. Epub 2022 Mar 2.

Université Paris-Saclay, Inserm, Inflammation Microbiome Immunosurveillance, Châtenay-Malabry, France.

The skin is frequently exposed to chemical stress by organic chemicals or metal ions that can directly or indirectly challenge its immune components and may lead to T-cell-mediated delayed-type hypersensitivity reactions. The disruption of the skin's homeostasis by exposure to contact sensitizers (CSs) can trigger an inflammatory immune response that results in eczema and allergic contact dermatitis. The recognition of these chemicals depends on the expression of pattern recognition receptors on sentinel skin cells, mainly the innate resident immune cells orchestrating the skin's immune response and involving both oxidative and inflammatory pathways. Read More

J Asthma Allergy 2022 2;15:145-155. Epub 2022 Feb 2.

College of Life Science, Institute of Life Sciences and Green Development, Hebei University, Baoding, Hebei Province, People's Republic of China.

Background: Occupational exposure to locusts induces a high prevalence of allergic sensitization. However, knowledge on occupational locust allergens remains unclear.

Objective: This study aimed to identify the allergens from locusts causing occupational allergies. Read More