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Contact Dermatitis 2019 Apr 21. Epub 2019 Apr 21.

Department of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Background: Retinoic acid (RA) induced dermatitis is the most frequent side effect which limits its wide use. However, the exact mechanisms triggering dermatitis is not fully understood, including the role of skin mast cells. The newly discovered MRGPRX2 in mast cells mediates pseudoallergic drug reactions in several types of dermatitis. Read More

Brain Behav Immun 2019 Apr 11. Epub 2019 Apr 11.

Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

Spontaneous itch and pain are the most common symptoms in various skin diseases, including allergic contact dermatitis (ACD). The chemokine (C-C motif) ligand 2 (CCL2, also referred to as monocyte chemoattractant protein 1 (MCP-1)) and its receptor CCR2 are involved in the pathophysiology of ACD, but little is known of the role of CCL2/CCR2 for the itch- and pain-behaviors accompanying the murine model of this disorder, termed contact hypersensitivity (CHS). C57BL/6 mice previously sensitized to the hapten, squaric acid dibutyl ester, applied to the abdomen were subsequently challenged twice with the hapten delivered to either the cheek or to the hairy skin of the hind paw resulting in CHS at that site. Read More

Postepy Dermatol Alergol 2019 Feb 22;36(1):98-103. Epub 2019 Feb 22.

Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari-Aldo Moro, Bari, Italy.

Introduction: Onion (Allium cepa) handling can induce contact dermatitis, rhinoconjunctivitis and asthma. However, only sporadic reports exist on allergic reactions to onion consumption.

Aim: We describe herein a case of a 35-year-old man who had an episode of anaphylaxis following cooked onion ingestion. Read More

Allergy 2019 Mar 4. Epub 2019 Mar 4.

Department of Dermatology, Venereology, and Allergology, University Medical Center, Georg August University, Göttingen, Germany.

Background: Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance. Loss-of-function mutations of these genes constitute a risk factor for atopic dermatitis and eczema-related asthma. Read More

Arch Toxicol 2019 Feb 26. Epub 2019 Feb 26.

UMR996-Inflammation, Chemokines and Immunopathology, INSERM, Univ Paris-Sud, Université Paris-Saclay, 92296, Châtenay-Malabry, France.

According to the current scientific consensus, one in vitro test is insufficient to cover the key events (KE) defined by the adverse outcome pathway (AOP) for skin sensitization. To address this issue we combined different end points in the same cell line to cover all KEs defined by the skin sensitization AOP. Since dendritic cells (DC) play a key role in the sensitization phase leading to the development of allergic contact dermatitis (ACD), we used THP-1 cells as a surrogate for DC. Read More

Sci Rep 2019 Feb 7;9(1):1603. Epub 2019 Feb 7.

Philips Research, High Tech Campus 11, 5656 AE, Eindhoven, The Netherlands.

Signal transduction pathways are important in physiology and pathophysiology. Targeted drugs aim at modifying pathogenic pathway activity, e.g. Read More

Toxicol Lett 2019 May 31;305:81-93. Epub 2019 Jan 31.

College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, South Korea. Electronic address:

Although several in vitro approaches were successful in separating chemicals as skin sensitizers and non-sensitizers, none of the available methods completely mimics the absolute in vivo scenario of skin sensitization. One of the major challenges with currently available systems would be the limited or no metabolic capacity to activate pre- or pro-haptens to reactive metabolites in the system. In the present study, E. Read More

J Allergy Clin Immunol 2019 Jan 15. Epub 2019 Jan 15.

CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; INSERM, U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon, France; CNRS, UMR 5308, Lyon, France. Electronic address:

Background: Tissue-resident memory T (Trm) cells are detrimental in patients with numerous chronic inflammatory diseases, including allergic contact dermatitis (ACD).

Objectives: We sought to analyze the contribution of Trm cells to the chronicity and severity of ACD and to define the local parameters regulating their development and functions.

Methods: We used an experimental model of ACD (ie, contact hypersensitivity to 2,4-dinitrofluorobenzene) that is mediated by CD8 T cells. Read More

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid, Spain.

Nat Commun 2019 01 14;10(1):190. Epub 2019 Jan 14.

Blood Research Institute, Versiti Wisconsin, Milwaukee, WI, USA.

A number of different B cell subsets have been shown to exhibit regulatory activity using a variety of mechanisms to attenuate inflammatory diseases. Here we show, using anti-CD20-mediated partial B cell depletion in mice, that a population of mature B cells distinguishable by IgD expression maintains tolerance by, at least in part, promoting CD4Foxp3 regulatory T cell homeostatic expansion via glucocorticoid-induced tumor necrosis factor receptor ligand, or GITRL. Cell surface phenotyping, transcriptome analysis and developmental study data show that B cells expressing IgD at a low level (BD) are a novel population of mature B cells that emerge in the spleen from the transitional-2 stage paralleling the differentiation of follicular B cells. Read More

J Ethnopharmacol 2019 Apr 7;233:141-147. Epub 2019 Jan 7.

Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan-city, Gyeongnam 50612, South Korea.

Ethnopharmacological Relevance: The roots and rhizomes of Gentiana scabra Bunge in the family Gentianaceae comprise a major herbal medicine for skin diseases caused by wind-heat or dampness-heat in China, Japan and Korea. This treatment can clear away heat and dry dampness and purge fire from the liver and gallbladder.

Aim Of The Study: This study was designed to investigate the therapeutic potential and anti-inflammatory effects of G. Read More

J Am Acad Dermatol 2019 Apr 8;80(4):1166-1167. Epub 2019 Jan 8.

Tufts Medical Center, Boston, Massachusetts. Electronic address:

Part Fibre Toxicol 2019 01 8;16(1). Epub 2019 Jan 8.

Department of Environmental Medicine, University of Rochester Medical Center, New York, USA.

Background: The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxylation in MWCNT skin toxicity.

Results: MWCNTs were analyzed by transmission electron microscopy, zetasizer, and x-ray photoelectron spectroscopy to fully characterize the physical properties. Read More

Int Marit Health 2018;69(4):264-269

Maritime Health Unit, ISM Tarragona, Spain, Spain.

Background: Anisakis is a marine nematode. Its larvae can be found encysted in several species, both in the abdominal cavity and in the adjacent musculature. The most commonly affected commercial species are hake, whiting, cod, and mackerel. Read More

J Toxicol Sci 2018 ;43(12):741-749

Department of Dermatology, Tohoku University Graduate School of Medicine.

In all current in vitro skin sensitisation assays, DMSO is used to dissolve water-insoluble chemicals. However, our previous study suggested the superiority of the modified IL-8 Luc assay (mIL-8 Luc), in which X-VIVO 15 is used to dissolve chemicals, over the original assay using DMSO (oIL-8 Luc). In this study, to confirm the superiority of the mIL-8 Luc, we first increased the number of chemicals examined and demonstrated the superiority of the mIL-8 Luc, in which the mIL-8 Luc provided 87. Read More

Vet Immunol Immunopathol 2018 Dec 13;206:35-40. Epub 2018 Nov 13.

Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CL, The Netherlands; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, 0110, South Africa. Electronic address:

Keratinocytes (KC) are the main cellular components of the stratum corneum that constitutes a solid physical skin barrier representing the first line of defense against pathogens. Moreover, KC are potent producers of inflammatory mediators and antimicrobial peptides (AMP) when activated through their pattern recognition receptors. In atopic dermatitis (AD) the protective skin barrier may be compromised due to barrier disruption, secondary infection and accelerated secretion of inflammatory cytokines which may also affect AMP expression in the skin. Read More

Toxicol Sci 2019 Mar;168(1):179-189

Pharmaceutical Sciences Department, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73117.

Irritant contact dermatitis (ICD), the most common occupational cutaneous illness, is an acute inflammatory response caused by topical irritant exposure. Multiple factors are associated with the manifestation and severity of ICD and contribute to the lack of effective prophylactic and treatment strategies. To determine the pathomechanism of ICD caused by the irritants, benzalkonium chloride (BKC) and JP-8 jet fuel, 2 mouse strains, C57BL/6 and Balb/c, were assessed due to their differential immune predispositions. Read More

J Clin Med 2018 Nov 27;7(12). Epub 2018 Nov 27.

Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.

Hexavalent chromium (Cr(VI)) is widely used in many industries but can induce contact dermatitis especially in cement industries. Many cement workers suffer from Cr(VI)-induced allergic contact dermatitis (ACD), and prevention and therapeutic strategies are still lacking. Pterostilbene (PT) is a natural compound predominantly found in blueberries. Read More

An Bras Dermatol 2018 Nov/Dec;93(6):829-835

Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP), Brazil.

Background: Allergic contact dermatitis to ion nickel (Ni+2) is an inflammatory dermatosis, common in industrialized countries. It involves the activation of nickel-specific T-cells, followed by proliferation and induction of a mixed profile of both proinflammatory and regulatory cytokines, suggesting that several T-cell subtypes (helper - Th and cytotoxic - Tc) are involved. A broader understanding of the cytokine profile may lead to new therapeutic approaches. Read More

Environ Toxicol 2019 Mar 21;34(3):262-270. Epub 2018 Nov 21.

DOS in Biochemistry, University of Mysore, Manasagangothri, Mysuru, India.

The catecholic derivative para-tertiary butyl catechol (PTBC) is a conventional antioxidant and polymerization inhibitor, which exhibits melanocytotoxic effects and contact dermatitis often leading to occupational leucoderma or vitiligo. Although numerous industrial workers will be in constant exposure to PTBC and its chances of getting entry into blood are most expected, its effect on blood components is still undisclosed. As platelets play a prominent role in dermatitis, inflammation, and immunity, in this study we have evaluated the effect of PTBC on human platelets in vitro. Read More

J Ethnopharmacol 2019 Mar 13;231:205-216. Epub 2018 Nov 13.

Laboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Background: Tabernaemontana catharinensis, popularly known as snake skin, has been empirically used as an anti-inflammatory to treat cutaneous skin disorders. However, no study proves its effectiveness as a topical anti-inflammatory.

Study Design: We investigated the topical anti-inflammatory effect of T. Read More

Biosci Biotechnol Biochem 2019 Mar 10;83(3):525-530. Epub 2018 Nov 10.

c Department of Nutritional Science, Faculty of Health and Welfare Science , Okayama Prefectural University , Okayama , Japan.

Contact hypersensitivity (CHS) is frequently used as an animal model for human allergic contact dermatitis (ACD). Diets of pomegranate polyphenols (PPs) or soy isoflavones (SIs) each alleviated CHS symptoms; however, the effect of diets containing a mixture of PPs and SIs on CHS is unclear. We investigated the CHS-inhibitory effects of diets supplemented with a mixture of PPs and SIs at human physiologically relevant doses. Read More

Int J Mol Sci 2018 Nov 7;19(11). Epub 2018 Nov 7.

Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University, Gyeonggi-do 13120, Korea.

is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of grown on germinated (GRC) fermented with ON89A isolated from onion (GRC-ON89A) in vivo as well as in vitro. The anti-inflammatory effect of GRC-ON89A was investigated in lipopolysaccharide (LPS)-stimulated RAW 264. Read More

Biomed Pharmacother 2019 Jan 4;109:646-657. Epub 2018 Nov 4.

Laboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Ethnopharmacological Relevance: Tabernaemontana catharinensis, popularly known as snakeskin, is used in traditional medicine to treat skin inflammatory disorders. To confirm the topical anti-inflammatory effect of T. catharinensis leaves, we evaluated the therapeutic effect of crude extract (TcE) and its different fractions on irritant contact dermatitis model in mice and verified its anti-inflammatory action mechanism. Read More

Acta Orthop 2018 Dec 29;89(6):646-651. Epub 2018 Oct 29.

b Department of Trauma Surgery and Orthopaedics , Klinikum Memmingen, Germany (Academic Teaching Hospital of Ludwig-Maximilians-University Munich) ;

Background and purpose - Metal sensitivity might provoke complications after arthroplasty. Correspondingly, coated "hypoallergenic" implants are of interest but long-term follow-up data are missing. Thus, we assessed immunological and clinical parameters in such patients. Read More

Curr Pharm Biotechnol 2018 ;19(11):910-916

Federal State Budgetary Institution "Research Institute of Basic and Clinical Immunology", Novosibirsk, Russian Federation.

Background: Large DNA poxviruses encode a diverse family of secreted proteins that modulate host inflammatory and antiviral responses, in particular by inhibiting one of the key players of the mammalian immune system, the tumor necrosis factor (TNF).

Methods: We investigated the effects of a recombinant variola (smallpox) virus TNF-decoy receptor (VARV-CrmB) in a murine model of contact dermatitis. Our results demonstrate that the VARV-CrmB protein significantly reduces the 2,4-dinitrochlorbenzene (DNCB)-induced migration of skin leukocytes during the sensitization phase and suppresses ear oedema during the elicitation phase of the contact reaction. Read More

Contact Dermatitis 2019 Feb 29;80(2):86-93. Epub 2018 Oct 29.

National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Background: Knowledge about the skin deposition and penetration of nickel into the stratum corneum (SC) after short contact with metallic items is limited.

Objective: To quantify nickel skin deposition and penetration into the SC after short contact with metallic nickel.

Methods: Sixteen nickel-allergic participants and 10 controls were exposed to 3 pure nickel discs and 1 aluminium disc on each volar forearm for 3 × 10 minutes. Read More

Eur J Med Chem 2019 Jan 13;161:239-251. Epub 2018 Oct 13.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy.

A set of CB2R ligands, based on the thiophene scaffold, was synthesized and evaluated in in vitro assays. Compounds 8c-i, k, l, bearing the 3-carboxylate and 2-(adamantan-1-yl)carboxamido groups together with apolar alkyl/aryl substituents at 5-position or at 4- and 5-positions of the thiophene ring possess high CB2R affinity at low nanomolar concentration, good receptor selectivity, and agonistic functional activity. The full agonist 8g, showing the best balance between receptor affinity and selectivity, was tested in vitro in an experimental model of allergic contact dermatitis and proved to be able to block the release of MCP-2 in HaCaT cells at 10 μM concentration. Read More

J Ethnopharmacol 2019 Jan 17;229:190-204. Epub 2018 Oct 17.

Laboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil; Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Ethnopharmacological Relevance: Inflammatory skin diseases treatments currently used cause adverse effects. Nasturtium officinale (watercress) is used popularly as an anti-inflammatory. However, until now, no study proved its effectiveness as a topical treatment to inflammatory skin diseases. Read More

Food Chem 2019 Jan 9;272:33-38. Epub 2018 Aug 9.

Research Institute for Creating Future, Fuji Oil Holdings Inc., 1 Sumiyoshi, Izumisano, Osaka 598-8540, Japan.

Soy isoflavones (SIs) are abundant in soybeans and have inhibitory effects on contact hypersensitivity (CHS), which is often used as a mouse model for allergic contact dermatitis (ACD); however, their therapeutic mechanisms remain unknown. We studied the suppressive activity of dietary SI and gut microbiota on dinitrofluorobenzene (DNFB)-induced CHS. Low-dose SI diets alleviated DNFB-induced ear swelling and oedema and decreased infiltration of Gr-1-positive cells into ear tissue. Read More

Biol Pharm Bull 2018 ;41(10):1554-1560

Tokyo University of Technology Graduate School, Department of Bionics.

Sacran, a polysaccharide isolated from the alga Aphanothece sacrum (Suizenji-nori), has unique physical and physiological characteristics. In a previous study, we reported that sacran improves skin conditions in individuals who suffer from atopic dermatitis (AD), focusing on its trapping function against extrinsic stimuli compared with hyaluronic acid (HA). First, we examined the penetration of sacran through stratum corneum (SC) with an impaired barrier function using immature reconstructed human epidermal equivalents. Read More

Contact Dermatitis 2018 Dec 28;79(6):346-355. Epub 2018 Sep 28.

de Duve Institute, MEXP Unit, Université catholique de Louvain, Brussels, Belgium.

Background: Allergic contact dermatitis has been described as a type IV reaction caused by antigen-specific T cells. Central roles for CD8 cytotoxic T cells as effector cells and CD4 T cells as regulatory cells have been suggested. T helper (Th) 2 and Th1 cytokines have been implicated; however, the nature of the allergen influences the Th response. Read More

Proc Natl Acad Sci U S A 2018 10 24;115(41):10404-10409. Epub 2018 Sep 24.

Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, 69365 Lyon Cedex 07, France;

Prominent changes in the gut microbiota (referred to as "dysbiosis") play a key role in the development of allergic disorders, but the underlying mechanisms remain unknown. Study of the delayed-type hypersensitivity (DTH) response in mice contributed to our knowledge of the pathophysiology of human allergic contact dermatitis. Here we report a negative regulatory role of the RIG-I-like receptor adaptor mitochondrial antiviral signaling (MAVS) on DTH by modulating gut bacterial ecology. Read More

Planta Med 2018 Sep 24. Epub 2018 Sep 24.

Freie Universitaet Berlin, Institute of Pharmacy, Department of Pharmaceutical Biology, Berlin, Germany.

In recent years, skin reactions such as phytophotodermatitis, contact dermatitis, and other inflammatory responses after contact with chemicals from various plants, e.g., or , are one of the hot topics in phytobiology. Read More

Int J Mol Sci 2018 Sep 7;19(9). Epub 2018 Sep 7.

Department of Immunology, Jagiellonian University Medical College, 31-121 Krakow, Poland.

Antibody light chains (LCs), formerly considered a waste product of immunoglobulin synthesis, are currently recognized as important players in the activation of the immune response. However, very little is known about the possible immune regulatory functions of LCs. Recently, we reported that hapten-specific LCs coat miRNA-150-carrying exosomes produced by CD8+ suppressor T cells downregulating the contact hypersensitivity (CHS) reaction in an antigen-specific manner, in mice tolerized by intravenous administration of a high dose of hapten-coupled syngeneic erythrocytes. Read More

Int J Mol Sci 2018 Sep 6;19(9). Epub 2018 Sep 6.

Laboratory of Experimental Immunology, IDI-IRCCS, 00167 Rome, Italy.

Human keratinocytes were recently shown to respond to anti-EGFR (epidermal growth factor receptor) drugs with activation of an interferon-κ-driven autocrine loop, leading to enhanced expression of innate antiviral effectors and of the pro-inflammatory chemokines CXCL10 (C-X-C motif chemokine 10) and CCL2 (C-C motif ligand 2). Here we showed active type I interferon signaling in the skin lesions of cancer patients undergoing treatment with the anti-EGFR drug cetuximab. Strong nuclear positivity for Interferon Regulatory Factor 1 and phosphorylated Signal Transducer and Activator of Transcription 1, enhanced interferon-κ expression and CXCL10 was associated to the epidermal compartment. Read More

Allergol Immunopathol (Madr) 2019 Jan - Feb;47(1):47-51. Epub 2018 Sep 5.

Istanbul University, Istanbul Medical Faculty, Department of Pediatric Allergy and Immunolgy, Istanbul, Turkey.

Background: Atopic dermatitis is a common illness in childhood. Children with atopic dermatitis are prone to develop cutaneous sensitization due to skin barrier dysfunction.

Aim: The aim of this study was to evaluate the frequency of cutaneous sensitizations in patients with atopic dermatitis and to identify the most frequent causative allergens. Read More

Clin Exp Dermatol 2018 Sep 6. Epub 2018 Sep 6.

Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan.

Background: Tinea is an infectious disease by dermatophytes, of which Trichophyton species accounts for the overwhelming majority of case. Tinea often causes itching with inflammation. In terms of pruritus by fungal infection, however, tinea has not been investigated sufficiently to date. Read More

Exp Ther Med 2018 Sep 23;16(3):2763-2769. Epub 2018 Jul 23.

Department of Gerontology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430014, P.R. China.

Mast cells (MCs) have been reported to serve a crucial role in allergic diseases, including asthma, allergic rhinitis and anaphylaxis. A previous study revealed that microRNA-126 (miR-126) was associated with airway hyperresponsiveness induced by house dust mites, however the molecular mechanisms were unclear. The present study aimed to investigate the effect of miR-126 on immunoglobulin E (IgE)-regulated MC degranulation and explore its underlying mechanisms. Read More

Dermatitis 2018 Sep/Oct;29(5):282-284

From the University of Texas Southwestern Medical Center, Dallas.

Allergic contact dermatitis to metals has become increasingly recognized in patients with endovascular implants. The ACD can lead to in-stent restenosis as well as a prominent eczematous reaction overlying the implant, often necessitating its removal. We present a case of refractory allergic contact dermatitis to nickel in a 44-year-old man with numerous endovascular stents and vascular clips. Read More

Contact Dermatitis 2018 Dec 22;79(6):336-345. Epub 2018 Aug 22.

Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam UMC, Amsterdam, The Netherlands.

Background: During the last decade, the number of people with ≥1 tattoo has increased noticeably within the European population. Despite this, limited safety information is available for tattoo inks.

Objectives: To test the skin sensitization potential of 5 tattoo inks in vitro by using reconstructed human skin (RHS) and the contact sensitization biomarker interleukin (IL)-18. Read More

Food Chem 2018 Dec 27;269:652-660. Epub 2018 Jun 27.

Proteomics Unit, Quadram Institute Bioscience, Norwich Research Park, NR4 7UA England, United Kingdom; Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milano, Italy. Electronic address:

Mango allergy is a rare condition, which may cause severe hypersensitivity reactions, such as anaphylaxis, angioedema, asthma and contact dermatitis. By exploiting the combinatorial peptide ligand library (CPLL) technology, mango proteomes have been extracted and the presence of traces of allergens assessed via Western blot analysis two-dimensional maps. Upon reactive spot elution and mass spectrometry analyses, four major mango allergens could be identified for the first time and shown to be in common with three of the five known banana species. Read More

Arch Toxicol 2018 Oct 10;92(10):3031-3050. Epub 2018 Aug 10.

Department of Forensic Sciences and Toxicology, University of Crete, Heraklion, Greece.

Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. One of the most frequent manifestations of chemical allergy is contact hypersensitivity, which can have serious impact on quality of life. Allergic contact dermatitis is a predominantly CD8 + T cell-mediated immune disease, resulting in erythema and eczema. Read More

J Am Acad Dermatol 2019 Jan 6;80(1):280-281.e1. Epub 2018 Aug 6.

Department of Dermatology, Loma Linda University, Loma Linda, California. Electronic address:

Clin Immunol 2018 Oct 2;195:67-76. Epub 2018 Aug 2.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Radix Astragali, has long been used to alleviate allergic diseases (ADs). Formononetin is one of the major active components in Radix Astragali, but its mechanism on ADs is not definitively known. The fluorescein isothiocyanate isomer-induced atopic contact dermatitis mouse model and poly I:C or lipopolysaccharide-treated HaCaT cells were used to examine thymic stromal lymphopoietin (TSLP)/interleukin (IL)-33 production and expression of E-cadherin. Read More

Proc Natl Acad Sci U S A 2018 08 2;115(34):E8017-E8026. Epub 2018 Aug 2.

Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, Germany;

T cells critically depend on reprogramming of metabolic signatures to meet the bioenergetic demands during activation and clonal expansion. Here we identify the transcription factor Nur77 as a cell-intrinsic modulator of T cell activation. Nur77-deficient T cells are highly proliferative, and lack of Nur77 is associated with enhanced T cell activation and increased susceptibility for T cell-mediated inflammatory diseases, such as CNS autoimmunity, allergic contact dermatitis and collagen-induced arthritis. Read More

Nat Commun 2018 08 1;9(1):3020. Epub 2018 Aug 1.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Lymphotoxin-beta receptor (LTβR) signaling in lymphatic endothelial cells (LEC) regulates leukocyte afferent lymphatic transendothelial migration (TEM). The function of individual signaling pathways for different leukocyte subsets is currently unknown. Here, we show that LTβR signals predominantly via the constitutive and ligand-driven non-classical NIK pathway. Read More

Acta Dermatovenerol Croat 2017 Dec;25(4):312-313

lisa Moliterni, MD 2Sapienza University of Rome, Umberto I Polyclinic, Dermatology Department Viale del Policlinico 156 00186 Rome Italy

Hand eczema is a chronic disease (1), commonly considered the expression of a contact allergic or irritative dermatitis. However, when the prick/patch tests and laboratory investigations are negative, important diagnostic challenges may arise. Peripheral nerve fibers are in fact capable of releasing neuromediators. Read More

J Cosmet Sci 2018 May/Jun;69(3):213-228

Colgate-Palmolive Company, Piscataway, NJ (J.M.S., S.C., N.S., Z.N., L.P.).

Regular usage of cosmetic products and drugs in dermatological vehicles may cause irritant contact dermatitis. For example, aluminum chloride (AlCl), the most efficacious antiperspirant salt to treat hyperhidrosis, shows high irritancy potential. To mitigate the irritant contact dermatitis caused by topical application of products containing AlCl, we investigated the anti-irritating effects of aloe extract and taurine and . Read More