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    Contact sensitizers trigger human CD1-autoreactive T-cell responses.
    Eur J Immunol 2017 Apr 25. Epub 2017 Apr 25.
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore.
    Allergic contact dermatitis is a primarily T-cell-mediated inflammatory skin disease induced by exposure to small molecular-weight haptens, which covalently bind to proteins. The abundance of cutaneous T cells that recognize CD1a antigen-presenting molecules raises the possibility that MHC-independent antigen presentation may be relevant in some hapten-driven immune responses. Here we examine the ability of contact sensitizers to influence CD1-restricted immunity. Read More

    Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model.
    Int J Mol Sci 2017 Mar 30;18(4). Epub 2017 Mar 30.
    College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungduk-gu, Cheongju 361-951, Korea.
    Centella asiatica has potent antioxidant and anti-inflammatory properties. However, its anti-dermatitic effect has not yet been reported. In this study, we investigated the anti-dermatitic effects of titrated extract of Centella asiatica (TECA) in a phthalic anhydride (PA)-induced atopic dermatitis (AD) animal model as well as in vitro model. Read More

    Skin sensitizers in cosmetics and beyond: potential multiple mechanisms of action and importance of T-cell assays for in vitro screening.
    Crit Rev Toxicol 2017 Mar 22:1-18. Epub 2017 Mar 22.
    a Cosmetics Division, Office of Cosmetics and Colors (OCAC) , Center for Food Safety and Applied Nutrition (CFSAN), Food and Drug Administration (FDA) , MD , USA.
    Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity (DTH) reaction induced by repeated contact with sensitizers. The ability of a chemical to act as a sensitizer has most frequently been tested in animals. As the use of animals for these purposes is gradually and globally being phased out, there is a need for reliable in vitro surrogate assays. Read More

    Roles of alternatively activated M2 macrophages in allergic contact dermatitis.
    Allergol Int 2017 Mar 17. Epub 2017 Mar 17.
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Alternatively activated macrophages (M2 macrophages) play key roles in the suppression of Th1 cell responses and the orchestration of tissue repair. However, recent studies have shown that M2 macrophages have potentials to produce high levels of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α, suggesting that M2 macrophages may exacerbate inflammation in some settings. In this regard, we have recently shown that large numbers of M2 macrophages accumulate in the sites of hapten-induced contact hypersensitivity (CHS), an animal model of allergic contact dermatitis, and that M2 macrophages exacerbate hapten-induced CHS by producing matrix metalloproteinase 12 (MMP12). Read More

    Occupational contact dermatitis from protein in sea products: who is the most affected, the fisherman or the chef?
    J Occup Med Toxicol 2017 10;12. Epub 2017 Feb 10.
    Service de dermato-vénéréologie CHRU Morvan, 2 avenue FOCH, Brest Cedex, 29609 France.
    Background: Protein contact dermatitis has frequently been reported in case studies (usually in cases involving contact with seafood products), but there are very few descriptive series. The objectives of this present study were firstly to determine the incidence of protein contact dermatitis among fishermen in France and compare it with data from onshore work involving seafood exposure. Second, to discover what factors could explain any differences. Read More

    Development of an in vitro method to estimate the sensitization induction level of contact allergens.
    Toxicol Lett 2017 Apr 9;271:1-11. Epub 2017 Feb 9.
    Laboratory of Toxicology, DiSFeB, Università degli Studi di Milano, Milan, Italy. Electronic address:
    No standardized in vitro methods to assess potency of skin sensitizers are available. Recently, we standardized a procedure which combines the epidermal equivalent potency assay with assessment of IL-18 to provide a single test for identification and classification of skin sensitizers. This current study aimed to extend tested chemicals, and to provide a simple in vitro method for estimation of the expected sensitization induction level interpolating in vitro EC50 and IL-18 SI2 values to predict LLNA EC3 and/or human NOEL from standards curves generated using reference contact allergens. Read More

    Tetradecanol reduces EL-4 T cell growth by the down regulation of NF-κB mediated IL-2 secretion.
    Eur J Pharmacol 2017 Mar 3;799:135-142. Epub 2017 Feb 3.
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea. Electronic address:
    Tetradecanol is a straight-chain saturated fatty alcohol purified from Dendropanax morbifera leaves. We found that tetradecanol (30μM) reduced specifically the growth of T cells such as EL-4 T cell and isolated murine CD4(+) T cells. In this study, we investigated the effects of tetradecanol on the regulation of interlukin-2 (IL-2), a potent T cell growth factor. Read More

    Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus.
    Parasit Vectors 2017 Jan 31;10(1):51. Epub 2017 Jan 31.
    Departament of Biochemistry and Immunology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, 14049-900, Brazil.
    Background: Ticks attach to and penetrate their hosts' skin and inactivate multiple components of host responses in order to acquire a blood meal. Infestation loads with the cattle tick, Rhipicephalus microplus, are heritable: some breeds carry high loads of reproductively successful ticks, whereas in others, few ticks feed and reproduce efficiently.

    Methods: In order to elucidate the mechanisms that result in the different outcomes of infestations with cattle ticks, we examined global gene expression and inflammation induced by tick bites in skins from one resistant and one susceptible breed of cattle that underwent primary infestations with larvae and nymphs of R. Read More

    Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression.
    BMC Complement Altern Med 2017 Jan 31;17(1):81. Epub 2017 Jan 31.
    Environnement and Health team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Safi, Morocco.
    Background: Several chronic inflammatory diseases are characterized by inappropriate CD4+ T cell response. In the present study, we assessed the ability of Capparis spinosa L. (CS) preparation to orientate, in vivo, the immune response mediated by CD4+ T cells towards an anti-inflammatory response. Read More

    Mouse Model of Hydroquinone Hypersensitivity via Innate and Acquired Immunity and its Promotion by Combined Reagents.
    J Invest Dermatol 2017 May 17;137(5):1082-1093. Epub 2017 Jan 17.
    Division of Molecular Regulation, Tohoku University Graduate School of Dentistry, Sendai, Japan.
    We established a mouse model of contact hypersensitivity (CHS) to hydroquinone (HQ), a widespread chemical in our environment. HQ was painted onto flanks; then, HQ was challenged by painting onto ear pinnas on days 7 and 14. The CHS after the second challenge was markedly greater than that after the first challenge. Read More

    Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway.
    Int J Mol Sci 2017 Jan 18;18(1). Epub 2017 Jan 18.
    Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
    Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. Read More

    Efficacy of a Film-Forming Medical Device Containing Piroxicam and Sun Filters in the Treatment of Multiple Actinic Keratosis Lesions in a Subject with a History of Kaposi Sarcoma.
    Case Rep Dermatol 2016 Sep-Dec;8(3):254-261. Epub 2016 Oct 4.
    Medical Department, Difa Cooper, IFC Group, Caronno Pertusella, Italy.
    Actinic keratosis (AK) is considered a premalignant form of skin cancer due to chronic sun exposure. In addition, human papilloma virus (HPV) has been advocated a role in the pathogenesis of this clinical condition. HPV proteins (mainly E6 and E7) seem to act synergistically with ultraviolet (UV) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after UV damage. Read More

    Reaction Chemistry to Characterize the Molecular Initiating Event in Skin Sensitization: A Journey to Be Continued.
    Chem Res Toxicol 2017 01 30;30(1):315-331. Epub 2016 Nov 30.
    Biosciences, Givaudan Schweiz AG , Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland.
    The publication by the OECD of the adverse outcome pathway (AOP) for skin sensitization has accelerated the development and validation of mechanistic tests and testing strategies to assess the potential of new molecules to trigger skin allergies. The molecular initiating event (MIE) in the AOP is reaction with skin peptides/proteins. It is followed by a number of cellular events. Read More

    Rubber: new allergens and preventive measures.
    Eur J Dermatol 2016 Dec;26(6):523-530
    Department of Occupational Diseases, Paris University Hospital, Centre Hôtel-Dieu, AP-HP 1, Parvis Notre-Dame, 75004 Paris, France.
    Natural rubber latex (NRL) and rubber accelerators are well-known causes of occupational skin diseases. The latest epidemiological data on rubber allergy show that rubber additives are still among the allergens most strongly associated with occupational contact dermatitis, however, a decrease in NRL allergy has been confirmed. A review of recent publications on rubber allergens based on the Pubmed database is presented. Read More

    Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
    Food Chem Toxicol 2017 Jan 18;99:60-69. Epub 2016 Nov 18.
    Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China. Electronic address:
    Diisodecyl phthalate (DIDP) is extensively used as an environmentally friendly plasticizer. However, little is known about the adverse effects and the underlying mechanisms of DIDP exposure on immunological diseases. We aimed to determine the role and mechanisms of DIDP exposure in allergic contact dermatitis-like skin lesions. Read More

    Tight junctions in skin inflammation.
    Pflugers Arch 2017 Jan 16;469(1):3-14. Epub 2016 Nov 16.
    Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
    Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e. Read More

    Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib.
    Eur J Pharmacol 2017 Jan 12;794:20-26. Epub 2016 Nov 12.
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, NC, USA. Electronic address:
    The janus kinase-inhibitor oclacitinib is licensed for the control of pruritus associated with allergic skin diseases in dogs. Strikingly, it has been clinically reported that abrupt withdrawal of oclacitinib leads to a rebound pruritus in dogs. Therefore, the primary objective of this study was to mimic the rebound phenomenon of oclacitinib using a chronic pruritic mouse model of allergic contact dermatitis. Read More

    Contact dermatitis and interferon-γ dependent chemokines.
    Clin Ter 2016 Sep-Oct;167(5):e112-e116
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Inflammation of the skin is the pathological base of contact dermatitis (CD), and cytokines are very important in its pathogenesis. Recently it has been shown that interferon (IFN)-γ, and the IFN-γ dependent chemokines, monokine induced by IFN-γ (MIG), IFN-γ-induced protein 10 (IP-10), and IFN-inducible T cell alpha chemoattractant (I-TAC), play an important role in CD. Allergic CD (ACD) is a T-cell-mediated disease in which expression of a distinct repertoire of chemokines results in the recruitment of effector T cells into the skin. Read More

    Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.
    J Clin Invest 2016 Dec 7;126(12):4497-4515. Epub 2016 Nov 7.
    Epidermal keratinocytes form a structural and immune barrier that is essential for skin homeostasis. However, the mechanisms that regulate epidermal barrier function are incompletely understood. Here we have found that keratinocyte-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic phenotype. Read More

    Proteomics analysis of dendritic cell activation by contact allergens reveals possible biomarkers regulated by Nrf2.
    Toxicol Appl Pharmacol 2016 Dec 3;313:170-179. Epub 2016 Nov 3.
    German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany.
    Allergic contact dermatitis is a widespread disease with high clinical relevance affecting approximately 20% of the general population. Typically, contact allergens are low molecular weight electrophilic compounds which can activate the Keap1/Nrf2 pathway. We performed a proteomics study to reveal possible biomarkers for dendritic cell (DC) activation by contact allergens and to further elucidate the role of Keap1/Nrf2 signaling in this process. Read More

    Preliminary analysis of Psoroptes ovis transcriptome in different developmental stages.
    Parasit Vectors 2016 Nov 4;9(1):570. Epub 2016 Nov 4.
    Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
    Background: Psoroptic mange is a chronic, refractory, contagious and infectious disease mainly caused by the mange mite Psoroptes ovis, which can infect horses, sheep, buffaloes, rabbits, other domestic animals, deer, wild camels, foxes, minks, lemurs, alpacas, elks and other wild animals. Features of the disease include intense pruritus and dermatitis, depilation and hyperkeratosis, which ultimately result in emaciation or death caused by secondary bacterial infections. The infestation is usually transmitted by close contact between animals. Read More

    In vivo skin penetration of macromolecules in irritant contact dermatitis.
    Int J Pharm 2016 Dec 19;515(1-2):384-389. Epub 2016 Oct 19.
    Institute of Pharmaceutical Technology, Pharmacy institutes, University of Bonn, Bonn, Germany; FDE (EA4267), university of Bourgogne Franche-Comté, Besançon, France.
    Recently, a selective preferential accumulation of polymeric nanoparticles (in the size range around 100nm) has been observed in the follicular system of dermatitis skin. The present investigation aimed at clearly investigating the effect of irritant contact dermatitis on the barrier permeability for colloidal systems below this size range, namely quantum dots and hydrophilic macromolecules. Irritant dermatitis was induced in mice and the penetrability of quantum dots (5nm) and hydrophilic dextran molecules has been tracked in both healthy and inflamed skin using confocal laser scanning microscopy. Read More

    c-CBL E3 Ubiquitin Ligase Expression Increases Across the Spectrum of Benign and Malignant T-Cell Skin Diseases.
    Am J Dermatopathol 2016 Oct 31. Epub 2016 Oct 31.
    *Department of Dermatology, University of Wisconsin, Madison, WI; and †Department of Dermatology, William S. Middleton VA Medical Center, Madison, WI.
    Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Read More

    The adverse outcome pathway for skin sensitisation: Moving closer to replacing animal testing.
    Altern Lab Anim 2016 Oct;44(5):453-460
    Laboratory of Mathematical Chemistry (LMC), As. Zlatarov University, Bourgas, Bulgaria.
    This article outlines the work of the Organisation for Economic Co-operation and Development (OECD) that led to being jointly awarded the 2015 Lush Black Box Prize. The award-winning work centred on the development of 'The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins'. This Adverse Outcome Pathway (AOP) has provided the mechanistic basis for the integration of skin sensitisation-related information. Read More

    The use of peptide reactivity assays for skin sensitisation hazard identification and risk assessment.
    Altern Lab Anim 2016 Oct;44(5):437-442
    The Procter & Gamble Company, Mason Business Center, Cincinnati, OH, USA.
    Over the past 20 years or more, investigators have been developing non-animal test methods for use in assessing the skin sensitisation potential of chemicals. In parallel with this effort, the key biological events of skin sensitisation have been well-characterised in an Adverse Outcome Pathway (AOP) proposed by the Organisation for Economic Co-operation and Development (OECD). The key molecular initiating event of this AOP is haptenation or covalent modification of epidermal proteins. Read More

    Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.
    Eur J Pharmacol 2016 Nov 5;791:669-674. Epub 2016 Oct 5.
    Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy; Endocannabinoid Research Group, Italy.
    In mice, 2,4-dinitrofluorobenzene (DNFB) induces contact allergic dermatitis (CAD), which, in a late phase, is characterized by mast cell (MC) infiltration and angiogenesis. Palmitoylethanolamide (PEA), an endogenous anti-inflammatory molecule, acts by down-modulating MCs following activation of the cannabinoid CB2 receptor and peroxisome proliferator-activated receptor-α (PPAR-α). We have previously reported the anti-inflammatory effect of PEA in the early stage of CAD. Read More

    Protein content of the Hylesia metabus egg nest setae (Cramer [1775]) (Lepidoptera: Saturniidae) and its association with the parental investment for the reproductive success and lepidopterism.
    J Proteomics 2017 Jan 25;150:183-200. Epub 2016 Aug 25.
    Mass Spectrometry Laboratory and GlycoLab, Department of Proteomics, Center for Genetic Engineering and Biotechnology, PO Box 6162, Havana, Cuba. Electronic address:
    Hylesia metabus is a neotropical moth possessing toxic setae, which once in contact with the skin cause a severe dermatitis to humans known as lepidopterism. The only known function of the setae in the life cycle is to provide protection during the mating and egg-hatching stages. Approximately 65% of the protein content of the setae is a cluster of five proteases (28-45kDa) showing sequence homology to other S1A serine proteases. Read More

    Long-term clinical safety and efficacy of brodalumab in the treatment of Japanese patients with moderate-to-severe plaque psoriasis.
    J Eur Acad Dermatol Venereol 2016 Nov 29;30(11):1957-1960. Epub 2016 Jun 29.
    Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan.
    Background: Brodalumab (KHK4827) is a human anti-interleukin-17-receptor A monoclonal antibody. In Japanese patients with moderate-to-severe plaque psoriasis, brodalumab showed rapid and robust efficacy and a favourable safety profile in a 12-week, phase 2, double-blind, randomized controlled trial.

    Objectives: To evaluate the long-term safety and efficacy of brodalumab, an extension of a phase 2 trial of Japanese patients with moderate-to-severe psoriasis was performed. Read More

    An individual approach to feline diabetes care: a case report and literature review.
    Acta Vet Scand 2016 Oct 20;58(Suppl 1):63. Epub 2016 Oct 20.
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, North Mymms, Hertfordshire, UK.
    Background: Achieving insulin independence is emerging as a realistic therapeutic goal in the management of feline diabetes mellitus.

    Case Presentation: The management of an 11-year-old spayed female Burmese cat presenting with diabetes mellitus after corticosteroid administration is described. Remission was achieved after the frequency of insulin administration was increased to four times a day, and supported by intensive home blood glucose monitoring and a high protein, low carbohydrate diet. Read More

    Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis.
    Arch Dermatol Res 2016 Dec 5;308(10):711-721. Epub 2016 Oct 5.
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
    In this study, we topically administered two antioxidant compounds, the manganese-porphyrin-derivatives BMX-001 and BMX-010, in a mouse model of allergic dermatitis and compared the efficacy for reduction of itch and inflammation. In vitro effects of BMX-001 and BMX-010 on keratinocytes, bone marrow derived dendritic cells (BMDCs) and T-cells were initially analysed. For assessment of scratching behaviour, BMX-001 and BMX-010 (0. Read More

    Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.
    J Leukoc Biol 2017 Mar 5;101(3):703-715. Epub 2016 Oct 5.
    UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France; and
    Allergic contact dermatitis (ACD) represents a severe health problem with increasing worldwide prevalence. It is a T-cell-mediated inflammatory skin disease caused by chemicals present in the daily or professional environment. NiSO4 and 2,4-dinitrochlorobenzene (DNCB) are 2 chemicals involved in ACD. Read More

    A proteomic approach for the identification of immunotoxic properties of Tulipalin A.
    Proteomics 2016 Dec 15;16(23):2997-3008. Epub 2016 Nov 15.
    Institute of Pharmacy, Pharmaceutical Biology, Ernst-Moritz-Arndt-University, Greifswald, Germany.
    The immune system is permanently exposed to several environmental influences that can have adverse effects on immune cells or organs leading to immunosuppression or inappropriate immunostimulation, called direct immunotoxicity. The natural compound Tulipalin A (TUPA), a lactone with α-methylene-γ-butyrolactone moiety, can influence the immune system and lead to allergic contact dermatitis. This in vitro study focused on effects of TUPA using two immune cell lines (Jurkat T cells and THP-1 monocytes). Read More

    Inhibitory effects of dietary soyasaponin on 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice.
    Exp Dermatol 2017 Mar 2;26(3):249-254. Epub 2017 Feb 2.
    Department of Applied Molecular Bioscience, Nagoya University, Aichi, Japan.
    Soyasaponins (SSs) abundant in soybean have anti-inflammatory activities; however, their therapeutic effects on allergic contact dermatitis (ACD) remain unknown. To assess the effects of SS-enriched diets on ACD, we used a mouse model of contact hypersensitivity (CHS). Mice were fed low-dose or high-dose SS-containing diets for 3 weeks prior to CHS induction with 2,4-dinitrofluorobenzene (DNFB). Read More

    Proposed ICDRG Classification of the Clinical Presentation of Contact Allergy.
    Dermatitis 2016 Sep-Oct;27(5):248-58
    From the *Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; †Allergy Center and Department of Dermatology, University Hospital, Republic University of Uruguay, Montevideo; ‡Department of Dermatology and Allergy Center, Center for Innovative Medical Technology, Institute of Clinical Research, University of Southern Denmark, Odense; §Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden; ∥Department of Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Germany; ¶Department of Dermatology, University Hospital Jena, Germany; #Department of Dermatology, National Skin Centre, Singapore; **Contact Allergy Unit, Department of Dermatology, University Hospital KU Leuven, Belgium; ††MGM Medical College, Kamothe, Mumbai, India; ‡‡Department of Dermatology, Catholic University of Louvain, Brussels, Belgium; §§Department of Dermatology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul; ∥∥Department of Dermatology, UCSF School of Medicine, San Francisco, CA; ¶¶Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ##Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation, Melbourne, Victoria, Australia; ***Institute of Dermatology, Bangkok, Thailand; †††Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal General Hospital, Quebec, Canada; ‡‡‡Dermatologic Department, Division of Medicine, Phramongkutklao Hospital, Bangkok, Thailand; and §§§Department of Cutaneous Allergy, St. John's Institute of Dermatology, King's College, Guy's Hospital, London, United Kingdom.
    The International Contact Dermatitis Research Group proposes a classification for the clinical presentation of contact allergy. The classification is based primarily on the mode of clinical presentation. The categories are direct exposure/contact dermatitis, mimicking or exacerbation of preexisting eczema, multifactorial dermatitis including allergic contact dermatitis, by proxy, mimicking angioedema, airborne contact dermatitis, photo-induced contact dermatitis, systemic contact dermatitis, noneczematous contact dermatitis, contact urticaria, protein contact dermatitis, respiratory/mucosal symptoms, oral contact dermatitis, erythroderma/exfoliative dermatitis, minor forms of presentation, and extracutaneous manifestations. Read More

    Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.
    BMC Complement Altern Med 2016 Sep 6;16:347. Epub 2016 Sep 6.
    Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea.
    Background: Sanguisorbae Radix (SR) is a well-known herbal medicine used to treat inflammatory disease and skin burns in Asia. In addition, it is used to treat many types of allergic skin diseases, including urticaria, eczema, and allergic dermatitis. SR has been reported to exhibit anti-wrinkle, anti-oxidant, and anti-contact dermatitis bioactivities. Read More

    Cosmetic components causing contact urticaria: a review and update.
    Contact Dermatitis 2016 Dec 4;75(6):333-344. Epub 2016 Sep 4.
    Department of Dermatology, University Hospitals KU Leuven, Leuven, 3000, Belgium.
    Immediate skin reactions are common in dermatological practice, but may often be overlooked. The main objective of this article is to provide an update of the literature concerning immediate-type reactions or contact urticaria/contact urticaria syndrome caused by cosmetic ingredients in terms of immediate clinical symptoms, positive reactions following open, scratch or, most often, prick testing, and sometimes the detection of specific IgE antibodies. To this end, a selective search in different medical literature databases was performed. Read More

    Histamine Modulates Sweating and Affects Clinical Manifestations of Atopic Dermatitis.
    Curr Probl Dermatol 2016 30;51:50-6. Epub 2016 Aug 30.
    Many factors such as food or environmental allergens, bacteria, fungi, and mental stress aggravate the condition of atopic dermatitis (AD) eczema. Sweating can also exacerbate AD, and patients are aware of that. In the past, it has been reported that contamination of skin surface antigens by sweat induces acute allergic reactions and that sweating functions of AD patients via axonal reflexes are decreased. Read More

    Allergy Testing.
    Prim Care 2016 Sep;43(3):363-74
    Department of Family Medicine, University of Pittsburgh Medical Center (UPMC) McKeesport Family Medicine Residency, 2347 Fifth Avenue, McKeesport, PA 15132, USA. Electronic address:
    Allergic diseases are common in outpatient primary care. Allergy testing can guide management to determine allergy as a cause of symptoms and target therapeutic interventions. This article provides a review of common methods of allergy testing available so that physicians may counsel and refer patients appropriately. Read More

    Neurotensin-based hybrid peptide's anti-inflammatory activity in murine model of a contact sensitivity response.
    Eur J Pharm Sci 2016 Oct 7;93:84-9. Epub 2016 Aug 7.
    Department of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, Poland.
    The objective of the study was to investigate the possibility of modulation of skin inflammation by topical treatment with a novel compound: an opioid-neurotensin hybrid peptide PK20 encompassing endomorphin-2 analog and modified fragment of neurotensin (8-13). Contact sensitivity response was induced in mice by skin sensitization with dinitrofluorobenzene (DNFB) followed by topical hapten application on ears. Mice were treated locally with PK20 or pure cream 2h after the challenge with DNFB. Read More

    The 'omics' revolution: redefining the understanding and treatment of allergic skin diseases.
    Curr Opin Allergy Clin Immunol 2016 Oct;16(5):469-76
    aDepartment of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA bDepartment of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel cLaboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA *Margeaux Oliva and Yael Renert-Yuval contributed equally to the article.
    Purpose Of Review: To evaluate how the genomic, transcriptomic, and proteomic profiles of allergic skin diseases, like atopic dermatitis and allergic contact dermatitis, contribute to their understanding and promote their therapeutic development.

    Recent Findings: The '-omics' revolution has facilitated the quantification of inflammatory skin diseases at the molecular level, expanding our understanding of disease pathogenesis. It has also greatly expanded once-limited treatment options and improved the ability to define posttreatment improvements, beyond clinical scores. Read More

    Genome-wide transcriptome induced by nickel in human monocytes.
    Acta Biomater 2016 Oct 28;43:369-82. Epub 2016 Jul 28.
    Center of Dento-Maxillo-Facial Medicine, University Hospital of Bonn, Bonn 53111, Germany.
    Unlabelled: Nickel-containing alloys are frequently used in the biomedical field, although, owing to corrosive processes metal ion leaching is inevitable. Due to nickel ion (Ni(2+)) leaching several adverse effects are described in the literature. However, only a few studies evaluated the genetic profile of Ni(2+) in human cells which is of great importance since nickel-induced effects differ between humans and mice as a result of species-specific receptor variability. Read More

    Consensus of classification trees for skin sensitisation hazard prediction.
    Toxicol In Vitro 2016 Oct 22;36:197-209. Epub 2016 Jul 22.
    Joint Research Centre, Via Enrico Fermi 2749, Ispra 21027, VA, Italy.
    Since March 2013, it is no longer possible to market in the European Union (EU) cosmetics containing new ingredients tested on animals. Although several in silico alternatives are available and achievements have been made in the development and regulatory adoption of skin sensitisation non-animal tests, there is not yet a generally accepted approach for skin sensitisation assessment that would fully substitute the need for animal testing. The aim of this work was to build a defined approach (i. Read More

    Occupational contact urticaria caused by food - a systematic clinical review.
    Contact Dermatitis 2016 Oct 18;75(4):195-204. Epub 2016 Jul 18.
    Department of Dermatology, University Hospital Jena, 07743, Jena, Germany.
    Food industry workers are at increased risk for occupational contact urticaria (CU). There are many foodstuffs that have been reported to cause occupational CU, including seafood, meat, vegetables, and fruits. The aim of this review is to summarize all reported occupational cases of CU in the food industry. Read More

    A variant of the CXCL11 gene may influence susceptibility to contact allergy, particularly in polysensitized patients.
    Contact Dermatitis 2016 Nov;75(5):303-307
    Information Network of Departments of Dermatology (IVDK), Georg-August-University Göttingen, 37075, Göttingen, Germany.
    Background: Hereditary factors may influence individual susceptibility to contact allergy.

    Objectives: To investigate genetic variants with impacts on early inflammatory reactions and T cell functions that possibly increase the risk of contact allergy.

    Patients And Methods: Three hundred and seventy two patients undergoing patch testing were recruited from the Information Network of Departments of Dermatology (IVDK). Read More

    [Latex allergy in a paediatric hospital. Characteristics and risk factors].
    Rev Chil Pediatr 2016 Nov - Dec;87(6):468-473. Epub 2016 Jun 25.
    Departamento de Pediatría Sur, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile. Electronic address:
    Introduction: The prevalence of latex sensitisation varies according to the population studied. There are various risk factors that increase latex sensitisation, such as genetic risk, atopy, and multiple surgeries.

    Objective: To characterise patients referred to an Immunology Unit with suspected latex allergy, and to analyse their clinical features and risk factors. Read More

    Contact eczema of hands caused by contact with potato protein.
    Ann Agric Environ Med 2016 Jun;23(2):377-8
    Department of Dermatology, Jagiellonian University Medical College, Cracow, Poland.
    Introduction: Protein contact dermatitis (PCD) is an IgE-dependent allergic reaction which, despite enormous progress in knowledge, remains a 'non-diagnosed' nosologic unit in contemporary medicine. Skin lesion, with a chronic and recurring course, are analogous with the clinical picture in allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD); skin patch tests, however, are usually negative. This makes the diagnostics difficult, prevents a correct diagnosis and treatment based on the avoidance of allergen. Read More

    Can contact allergy to p-phenylenediamine explain the high rates of terpene hydroperoxide allergy? - An epidemiological study based on consecutive patch test results.
    Contact Dermatitis 2017 Feb 1;76(2):67-73. Epub 2016 Jun 1.
    Department of Dermato-Allergology, National Allergy Research Centre, Herlev-Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
    Background: Contact allergy to linalool hydroperoxides (Lin-OOHs) and limonene hydroperoxides (Lim-OOHs) is common. Similarly to what occurs with the terpene hydroperoxides, reactive intermediates formed from p-phenylenediamine (PPD) can cause oxidative modifications of tryptophan residues on proteins in mechanistic studies.

    Objectives: To test the hypothesis that patients sensitized to PPD are at increased risk of concomitant reactivity to either of the terpene hydroperoxides, owing to a 'common pathway' of skin protein oxidation. Read More

    Paeoniflorin suppresses IL-6/Stat3 pathway via upregulation of Socs3 in dendritic cells in response to 1-chloro-2,4-dinitrobenze.
    Int Immunopharmacol 2016 Sep 26;38:45-53. Epub 2016 May 26.
    Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, PR China. Electronic address:
    Mounting evidence has suggested that inflammation is associated with IL-6/Stat3 pathway in dendritic cells (DCs) and Th17 cells, which are critical for development of allergic contact dermatitis (ACD). Paeoniflorin (PF) has been clinically proved to be effective in the treatment of inflammatory skin diseases such as ACD. We have previously demonstrated the effect of PF on DCs stimulated with 1-chloro-2,4-dinitrobenze (DNCB) and naïve CD4(+)CD45RA(+) T cells for Th17 cell differentiation. Read More

    Epidermal NLRP10 contributes to contact hypersensitivity responses in mice.
    Eur J Immunol 2016 Aug 16;46(8):1959-69. Epub 2016 Jun 16.
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
    The nucleotide binding and oligomerization domain-like receptor (NLR) protein NLRP10 is highly expressed in the epidermis and contributes to cell-autonomous responses against invasive bacteria. To investigate the role of NLRP10 in inflammatory responses of the skin we analyzed the effect of full-body and keratinocyte-specific depletion of NLRP10 in croton oil-induced irritant contact dermatitis (ICD) and 1-fluoro-2,4-dinitrobenzene (DNFB)-induced contact hypersensitivity (CHS) in mice. Nlrp10(-/-) mice were phenotypically normal and skin repair after wounding was not affected by lack of NLRP10. Read More

    Influence of different types of contact hypersensitivity on imiquimod-induced psoriasis-like inflammation in mice.
    Mol Med Rep 2016 Jul 18;14(1):671-80. Epub 2016 May 18.
    Department of Dermatology and Venereology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China.
    It is currently believed that psoriasis and allergic contact dermatitis (ACD) are different diseases; however, they share clinical similarities. The involvement of T helper 17 (Th17) cells in these disorders provides a novel opportunity to investigate the relationship between them. The present study aimed to determine whether the same or overlapping inflammatory pathways are involved in the two diseases, and the influence of different types of ACD on psoriasis. Read More

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