Polymorphic light eruption and IL-1 family members: any difference with allergic contact dermatitis?
Photochem Photobiol Sci 2017 Aug 16. Epub 2017 Aug 16.
Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy.
Polymorphic light eruption (PLE) is described as a delayed-type hypersensitivity reaction (DTHR) toward a de novo light-induced antigen, yet to be identified. In effect, the inflammatory pathways of PLE and allergic contact dermatitis (ACD) share common patterns in terms of the mediators involved from the innate and adaptive immune system participating in the DTHR. As we have previously highlighted the role of interleukin (IL)-1 family members in ACD, we hypothesised that the same mediators could have similar functions in PLE. Read More