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Int J Immunopathol Pharmacol 2020 Jan-Dec;34:2058738420929442

Department of Life Sciences, Institute of Biomedical Sciences, The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung.

Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that substantially affects a patient's quality of life. While steroids are the most common therapy used to temporally alleviate the symptoms of AD, effective and nontoxic alternatives are urgently needed. In this study, we utilized a natural, plant-derived phenolic compound, phloretin, to treat allergic contact dermatitis (ACD) on the dorsal skin of mice. Read More

Skin Pharmacol Physiol 2020 Jun 12:1-11. Epub 2020 Jun 12.

Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea,

Background: Essential oil derived from Chamaecyparis obtusa (EOCO) has been used as an alternative treatment for allergy-related diseases due to its immune-modulating characteristics. Clothing has the longest and most intense contact with human skin, and functional fabrics with intrinsic properties have been increasingly implemented in medical applications. Specially designed fabrics may support atopic dermatitis (AD) treatment. Read More

Endocr Metab Immune Disord Drug Targets 2020 Jun 7. Epub 2020 Jun 7.

Stefan S. Nicolau Institute of Virology, Bucharest. Romania.

Background: Despite significant progress in the diagnosis of contact dermatitis, the identification of specific tests or biomarkers remains an unsolved issue, particularly when needed for the confirmation of the occupational origin of the disease.

Objective: To characterize the plasma proteome profile in occupational dermatitis in workers from paint industry.

Methods: The study has a case-control design, comparing exposed workers with and without occupational contact dermatitis, matched for age, gender, occupational history and comorbidities. Read More

Front Immunol 2020 19;11:874. Epub 2020 May 19.

The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Allergic contact dermatitis (ACD) is a common inflammatory skin disease with a prevalence of approximately 20% in the European population. ACD is caused by contact allergens that are reactive chemicals able to modify non-immunogenic self-proteins to become immunogenic proteins. The most frequent contact allergens are metals, fragrances, and preservatives. Read More

Dermatol Clin 2020 Jul 17;38(3):301-308. Epub 2020 Apr 17.

University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Lakeside Suite 6223, Cleveland, OH 44106, USA. Electronic address:

The duration of cutaneous inflammation preceding sensitization influences the resulting allergic response; the innate immune system instructs the adaptive immune response. Potent allergens that function as their own irritant cause classic T helper cell type 1 skewed dermatitis. Examples include poison ivy, epoxy resin, and methylchloroisothiazolinone. Read More

J Cosmet Dermatol 2020 May 23. Epub 2020 May 23.

Department of Pharmaceutical Sciences & Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, India.

Background: Perfume is basically a cosmetic product applied to human body for an amusing scent or the feeling of freshness. A certain amount of perfume penetrates and remains attached to the protein of the skin when perfume is applied on the body. It evokes a surge of events in human immune system which results with allergic symptoms. Read More

J Am Acad Dermatol 2020 May 19. Epub 2020 May 19.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Institute of Allergy, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Contact Dermatitis 2020 Apr 25. Epub 2020 Apr 25.

Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Hyperkeratotic hand eczema (HHE) is a typical clinical hand eczema subtype with a largely unknown pathophysiology.

Objective: To investigate histopathology, expression of keratins (K), epidermal barrier proteins, and adhesion molecules in HHE.

Methods: Palmar skin biopsies (lesional and perilesional) were obtained from seven HHE patients and two healthy controls. Read More

Anticancer Agents Med Chem 2020 Apr 22. Epub 2020 Apr 22.

Biochemistry Department, Cairo University Research Park (CURP), Cairo University, Giza 12613. Egypt.

Background: Rosin (Colophony) is a natural resin derived from species of the pine family Pinaceae. It has wide industrial applications including printing inks, photocopying paper, adhesives and varnishes, soap and soda. Rosin and its derivatives are employed as ingredients in various pharmaceutical products such as ointments and plasters. Read More

Contact Dermatitis 2020 Apr 5. Epub 2020 Apr 5.

Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark.

Background: Naturally derived cosmetic product ingredients of both plant and animal origin are being included increasingly in product formulations in order to cater to consumer preferences. They may be an overlooked cause of reactions to cosmetic products in some patients with dermatitis.

Objectives: To identify naturally derived cosmetic product ingredients with allergenic potential (type I and type IV) and propose a cosmetic screening test series. Read More

Contact Dermatitis 2020 Jul 29;83(1):1-7. Epub 2020 Apr 29.

Finnish Institute of Occupational Health, Occupational Health Unit, Helsinki, Finland.

Background: Although occupational contact urticaria (CU) and protein contact dermatitis (PCD) are considered frequent among workers with exposure to proteinaceous materials, data on occupations at risk and the main causes of these occupational skin diseases are relatively limited.

Objectives: To report the causative agents and risk occupations for CU and PCD in the Finnish Register of Occupational Diseases (FROD).

Methods: We retrieved from the FROD all recognized cases of CU/PCD in the years 2005-2016. Read More

Cell Rep 2020 Mar;30(10):3448-3465.e8

Department of Immunology, University of Pittsburgh, School of Medicine Pittsburgh, PA, USA; Department of Dermatology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA; The McGowan Center for Regenerative Medicine, Pittsburgh, PA, USA. Electronic address:

Efficient Ca flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs). T cells express the neurokinin-1 receptor (NK1R), a GPCR that mediates Ca flux in excitable and non-excitable cells. However, the role of the NK1R in TCR signaling remains unknown. Read More

FASEB Bioadv 2020 Jan 24;2(1):59-71. Epub 2019 Dec 24.

Laboratory of Vaccine Materials Center for Vaccine and Adjuvant Research Laboratory of Gut Environmental System National Institutes of Biomedical Innovation Health and Nutrition (NIBIOHN) Osaka Japan.

Dietary intake of ω3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid is beneficial for health control. We recently identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a lipid metabolite endogenously generated from eicosapentaenoic acid that exhibits potent anti-allergic and anti-inflammatory properties. However, chemically synthesized 17,18-EpETE is enantiomeric due to its epoxy group-17(),18()-EpETE and 17(),18()-EpETE. Read More

Brain Res Bull 2020 May 26;158:66-76. Epub 2020 Feb 26.

Department of Pain Management, The State Key Clinical Specialty in Pain Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, P.R. China. Electronic address:

Intractable scratching is the characteristic of chronic itch, which represents a great challenge in clinical practice. However, the mechanism underlying chronic itch development is largely unknown. In the present study, we investigated the role of NMDA receptor in acute itch and in development of chronic itch. Read More

Exp Dermatol 2020 May 15;29(5):490-498. Epub 2020 Apr 15.

Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.

Background: Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are the cause of an increasing number of contact allergies. Understanding the mechanisms by which MCI/MI induces proinflammatory and regulatory factors production is necessary to understand the outcome of allergic contact dermatitis (ACD).

Objectives: To evaluate the dysfunction of proinflammatory cytokines and regulatory factors in the positive MCI/MI patch test at the transcriptional and protein expression levels. Read More

Dermatol Online J 2019 Dec 15;25(12). Epub 2019 Dec 15.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

As wearable devices play an increasing role in the management of health and disease, adverse skin reactions to wearables have become more common. However, the management of allergic contact dermatitis is challenging and new treatment options more compatible with wearable devices are needed. In a 40-year-old woman with contact dermatitis to a continuous glucose monitoring device, topical clobetasol propionate 0. Read More

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology, University of California San Diego, San Diego, CA.

Bullous pemphigoid (BP) is an autoimmune blistering disorder that predominantly affects the elderly. Treatment regimens typically include topical and systemic immunosuppressive medications. Although effective, systemic corticosteroids are sometimes poorly tolerated in the elderly patient, contributing to the overall morbidity and mortality of BP. Read More

Int Immunopharmacol 2020 Apr 7;81:106258. Epub 2020 Feb 7.

Department of Dermatology, Northwest Hospital, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of mast cell in tissues treated with IMQ, the possibility that IMQ-related dermatitis mediated by mast cell-specific Mas-related G protein-coupled receptor X2 (MRGPRX2) should be addressed. Read More

Contact Dermatitis 2020 Jun 26;82(6):337-342. Epub 2020 Feb 26.

Occupational Health Unit, Finnish Institute of Occupational Health (FIOH), Helsinki, Finland.

Background: Skin diseases are among the most common occupational diseases, but detailed analyses on their epidemiology, diagnoses, and causes are relatively scarce.

Objectives: To analyze data on skin disease in the Finnish Register of Occupational Diseases (FROD) for (1) different diagnoses and (2) main causes of allergic contact dermatitis (ACD).

Methods: We retrieved data on recognized cases with occupational skin disease (OSD) in the FROD from a 12-year-period 2005-2016 and used national official labor force data of the year 2012. Read More

Occup Med (Lond) 2020 Jun;70(4):282-285

Regional Centre for Asthma, Allergy and Hypersensitivity, Department of Respiratory Medicine, Oslo University Hospital, Oslo, Norway.

Protein contact dermatitis (PCD) often presents as chronic hand eczema (CHE) with an immediate hypersensitivity to protein proved by a positive skin prick test or by the presence of specific immunoglobulin E. This is frequently induced by occupational exposure to proteins in food workers, farmers, animal breeders, veterinarians and healthcare professionals. While skin barrier impairment is crucial in the pathogenesis of PCD, methods to assess skin barrier function such as trans-epidermal water loss and stratum corneum hydration are not widely used in clinical settings. Read More

J Proteomics 2020 Apr 30;217:103647. Epub 2020 Jan 30.

Department of Immunotechnology, Lund University, Medicon Village, Lund, Sweden. Electronic address:

We investigated the skin sensitization hazard of glyphosate, the surfactant polyethylated tallow amine (POEA) and two commercial glyphosate-containing formulations using different omics-technologies based on a human dendritic cell (DC)-like cell line. First, the GARD™skin assay, investigating changes in the expression of 200 transcripts upon cell exposure to xenobiotics, was used for skin sensitization prediction. POEA and the formulations were classified as skin sensitizers while glyphosate alone was classified as a non-sensitizer. Read More

J Extracell Vesicles 2020 18;9(1):1703480. Epub 2019 Dec 18.

Department of Integrative Biosciences, University of Brain Education, Cheonan, Republic of Korea.

Consumer interest in cosmetic industry products that produce whitening effects has increased demand for agents that decrease melanin production. Many such anti-melanogenic agents are associated with side effects, such as contact dermatitis and high toxicity, and also exhibit poor skin penetration. Considerable recent research has focused on plant-derived products as alternatives to chemotherapeutic agents that possess fewer side effects. Read More

Curr Opin Allergy Clin Immunol 2020 Apr;20(2):117-121

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidemiologie et de Sante Publique, AP-HP. Sorbonne Universite, Tenon Hospital, Department of Dermatology and Allergology, Paris, France.

Purpose Of Review: Protein contact dermatitis (PCD) is a chronic eczema because of immediate hypersensitivity to protein and not related to haptens. As it has to be diagnosed by prick tests, it is probably under-recorded and under-estimated that is why it is important for dermatologists, allergists and occupational physicians to better know this peculiar contact dermatitis.

Recent Findings: Some recent series have emphasized that PCD is mainly an occupational dermatosis, mainly observed in food handlers. Read More

Toxicol Lett 2020 Apr 17;322:50-57. Epub 2020 Jan 17.

Laboratory of Toxicology, Department of Environmental and Political Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.

Allergic contact dermatitis (ACD) is an important occupational and environmental disease caused by topical exposure to chemical allergens. In the EU, it has been calculated that 4 % of animals are used in toxicity test for the assessment of skin sensitization (Peiser et al., 2012). Read More

Int J Mol Sci 2020 Jan 11;21(2). Epub 2020 Jan 11.

Department of Psychiatry, University of Münster, 48149 Münster, Germany.

Contact hypersensitivity (CHS) is an established animal model for allergic contact dermatitis. Dendritic cells (DCs) play an important role in the sensitization phase of CHS by initiating T cell responses to topically applied haptens. The cannabinoid receptors 1 (CB1) and 2 (CB2) modulate DC functions and inflammatory skin responses, but their influence on the capacity of haptenized DCs to induce CHS is still unknown. Read More

Int J Womens Dermatol 2019 Dec 3;5(5):378-380. Epub 2019 Apr 3.

Department of Dermatology, Loma Linda University, Loma Linda, California.

Biol Pharm Bull 2020 ;43(1):129-137

Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine.

Allergic contact dermatitis (ACD) is one of the most common skin diseases caused by hapten-modified proteins. Metformin, a drug commonly prescribed for type II diabetes, has been demonstrated to have various biological functions beyond its antidiabetic effects. However, its role in ACD remains unknown. Read More

Altern Lab Anim 2019 Nov-Dec;47(5-6):174-195. Epub 2020 Jan 4.

Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

methods that can replace animal testing in the identification of skin sensitisers are now a reality. However, as cell culture and related techniques usually rely on animal-derived products, these methods may be failing to address the complete replacement of animals in safety assessment. The objective of this study was to identify the animal-derived products that are used as part of methods for skin sensitisation testing. Read More

Sci Immunol 2020 01 3;5(43). Epub 2020 Jan 3.

Columbia University Vagelos College of Physicians and Surgeons, Department of Dermatology, New York, NY 10032, USA.

During industrialization, humans have been exposed to increasing numbers of foreign chemicals. Failure of the immune system to tolerate drugs, cosmetics, and other skin products causes allergic contact dermatitis, a T cell-mediated disease with rising prevalence. Models of αβ T cell response emphasize T cell receptor (TCR) contact with peptide-MHC complexes, but this model cannot readily explain activation by most contact dermatitis allergens, which are nonpeptidic molecules. Read More

Reprod Biol 2020 Mar 28;20(1):3-8. Epub 2019 Dec 28.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India. Electronic address:

The toxicity of metals is a known phenomenon. Nickel toxicity is very common since nickel is used extensively both industrially and in items of personal use such as utensils and jewellery. Here we discuss human exposure to nickel and its toxicity in the light of the available scientific evidence to understand its underlying pathophysiology. Read More

BMC Pharmacol Toxicol 2019 12 21;20(1):86. Epub 2019 Dec 21.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China.

Background: T lymphocytes play an important role in contact hypersensitivity. This study aims to explore the immunosuppressive activity of SBF-1, an analog of saponin OSW-1, against T lymphocytes in vitro and in vivo.

Methods: Proliferation of T lymphocytes from lymph nodes of mice was determined by MTT assay. Read More

Immun Inflamm Dis 2020 03 11;8(1):24-29. Epub 2019 Dec 11.

Department of Dermatology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.

Background: A subset of patients with positive patch tests demonstrates systemic contact dermatitis (SCD) upon ingestion or inhalation of the allergen. Concern has been raised about the use of patch tests for protein allergens (APTs) to detect SCD in atopic dermatitis (AD) patients.

Methods: We present atopy patch test (APT) data for 97 people. Read More

Int Immunopharmacol 2020 Jan 9;78:106061. Epub 2019 Dec 9.

Department of Oriental Medicine Resources, Chonbuk National University, 79 Gobong-ro, Iksan, Jeollabuk-do 54596, Republic of Korea. Electronic address:

Xanthone is a phenolic compound found in a few higher plant families; it has a variety of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. However, the molecular and cellular mechanisms underlying the activity of xanthone in allergic contact dermatitis (ACD) remain to be explored. Therefore, this study aimed to investigate the regulatory effects of xanthone in ACD in human keratinocytes (HaCaT cell), and human mast cell line (HMC-1 cell) in vitro and in an experimental murine model. Read More

J Allergy Clin Immunol 2020 Jan 28;145(1):183-191.e10. Epub 2019 Nov 28.

Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Background: Chronic itch is a highly debilitating symptom among patients with inflammatory skin diseases. Recent studies have revealed that gastrin-releasing peptide (GRP) and its receptor (gastrin-releasing peptide receptor [GRPR]) in the spinal dorsal horn (SDH) play a central role in itch transmission.

Objective: We aimed to investigate whether GRP-GRPR signaling is altered in SDH neurons in a mouse model of chronic itch and to determine the potential mechanisms underlying these alterations. Read More

J Allergy Clin Immunol 2020 Feb 26;145(2):619-631.e2. Epub 2019 Nov 26.

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, and the Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland. Electronic address:

Background: p-Phenylenediamine (PPD) is a strong contact allergen used in hair dye that is known to cause allergic contact dermatitis (ACD). Both private and occupational exposure to PPD is frequent, but the effect of PPD exposure in nonallergic occupationally exposed subjects is unknown.

Objective: We sought to investigate the effects of PPD exposure on the skin of occupationally exposed subjects with and without clinical symptoms. Read More

Contact Dermatitis 2020 Mar 22;82(3):147-152. Epub 2019 Dec 22.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Filaggrin is an important protein for structure and function of the skin barrier. Filaggrin gene (FLG) mutations are known to result in dry skin, impaired skin barrier, and increased risk for atopic dermatitis. However, it is not clear whether these mutations are associated with contact allergy or hand eczema in adolescence. Read More

J Immunol Res 2019 29;2019:6276254. Epub 2019 Oct 29.

Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, 1110 N. Stonewall Avenue, Oklahoma City, OK 73117, USA.

Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22R axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown. Using a chemical model of ICD, it was observed that mice with a keratinocyte-specific knockout of IL-6R (IL-6R) presented with increased inflammation and IL-22R and IL-22 protein expression relative to WT following irritant exposure, indicating that IL-6R deficiency in epidermal keratinocytes leads to the upregulation of IL-22R and its ligand during ICD. Read More

Immunol Res 2019 10;67(4-5):382-389

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, U.O.C. Medicina Generale, Via F. Sforza 35, 20122, Milan, Italy.

Phototoxic reaction is a known feature of EPP at least in part triggered by the oxidative status, complement system activation, and mast cell response. The aim of this study was to verify some aspects involved in phototoxic reaction during a season. The complement system was evaluated by C3 assay, alternative pathway by factor-B, and classical pathway by C1q; oxidative status was tested with malondialdehyde (MDA) and mast cell by IL-10 assay. Read More

Adv Exp Med Biol 2020 ;1251:39-47

Department of Physiotherapy, Opole Medical School, Opole, Poland.

Atopic dermatitis (AD) is characterized by exacerbations and remissions of eczematous skin, underlain by impaired skin barrier and aberrant Th2-type and Th-22 cytokine production. A number of allergens, in particular contact with fur animals, may aggravate the disease. This study seeks to define the influence of having a regular contact with a pet cat at home on the severity of symptoms and signs of AD. Read More

Biochem Biophys Res Commun 2020 Jan 15;522(1):40-46. Epub 2019 Nov 15.

College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Republic of Korea; Department of Biological Science in Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, Republic of Korea. Electronic address:

Atopic dermatitis (AD) can occur in both children and adults, and the symptoms include itching and eczema, which in turn cause patients to suffer. Ophiopogonin D (OP-D) is a steroidal glycoside from Radix Ophiopogon japonicus, which is well known as an effective anti-inflammatory herbal medicine in many Asian countries. In this study, we aimed to investigate the anti-inflammatory effects of OP-D, using an AD mouse model and inflamed HaCaT cells. Read More

Toxicol Appl Pharmacol 2020 Jan 14;386:114828. Epub 2019 Nov 14.

College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea; Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

To elucidate the roles of epidermal keratinocytes in the toxicological outcomes of chemically induced contact dermatitis, genome-scale transcriptional analyses were performed using normal human keratinocytes (NHKCs) treated with 10 μM sodium lauryl sulfate (SLS) or 5 μM urushiol. In Gene Ontology (GO) enrichment analyses, SLS- and urushiol-induced upregulated DEGs are commonly associated with the regulation of pro-inflammatory responses and epidermal differentiation processes in NHKCs whereas cellular protein metabolic process was also identified as a commonly downregulated DEG signature. Among the downregulated DEGs, CXCL14 was investigated as a potential biomarker for a new in vitro skin sensitization test using OECD TG429 reference chemicals. Read More

Mycoses 2020 Feb 27;63(2):189-196. Epub 2019 Nov 27.

Drug Development Research Laboratories, Maruho Co., Ltd., Kyoto, Japan.

Background: Lanoconazole (LCZ) is a topical antifungal agent clinically used to treat fungal infections such as tinea pedis. LCZ has not only antifungal effects but also anti-inflammatory effects, which have the potential to provide additional clinical benefits. However, the characteristic features of the inhibitory effects of LCZ on skin inflammation remain unclear. Read More

PLoS One 2019 6;14(11):e0224448. Epub 2019 Nov 6.

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.

Background: The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by means of an interactome-based analysis of expression data.

Methods: Genes associated to the diseases were identified using data mining approaches, and their multimorbidity mechanisms in distinct cell types were characterized by means of an in silico analysis of the topology of the human interactome. Read More

Toxicol In Vitro 2020 Feb 24;62:104697. Epub 2019 Oct 24.

Centre for Proteomic Research, Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK; Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK. Electronic address:

The potential risk of skin sensitisation, associated with the development of allergic contact dermatitis (ACD), is a consideration in the safety assessment of new ingredients for use in personal care products. Protein haptenation in skin by sensitising chemicals is the molecular initiating event causative of skin sensitisation. Current methods for monitoring skin sensitisation rely on limited reactivity assays, motivating interest in the development of proteomic approaches to characterise the skin haptenome. Read More

Phytother Res 2020 Feb 31;34(2):401-408. Epub 2019 Oct 31.

School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Mas-related G protein-coupled receptor-X2 (MRGPRX2) expressed on mast cells (MCs) has been shown to be a pivotal target for pseudo-allergic diseases. Therefore, MRGPRX2 might be a therapeutic target for allergic contact dermatitis, atopic dermatitis, and red man syndrome. Paeoniflorin (PF) was reported to have an antiinflammatory effect in neuroinflammation, enteritis, and so forth. Read More

Int J Mol Sci 2019 Oct 28;20(21). Epub 2019 Oct 28.

Biology Department, Macalester College, Saint Paul, MN 55105, USA.

A history of allergies doubles the risk of vulvodynia-a chronic pain condition of unknown etiology often accompanied by increases in numbers of vulvar mast cells. We previously established the biological plausibility of this relationship in mouse models where repeated exposures to the allergens oxazolone or dinitrofluorobenzene on the labiar skin or inside the vaginal canal of ND4 Swiss Webster outbred mice led to persistent tactile sensitivity and local increases in mast cells. In these models, depletion of mast cells alleviated pain. Read More

Eur J Pharm Sci 2020 Jan 22;141:105110. Epub 2019 Oct 22.

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address:

Background: Allergic contact dermatitis (ACD) is a highly prevalent inflammatory and immune skin disease accompanied with persistent pruritus and pain. Oxymatrine (OMT) exhibits antipruritic and anti-inflammatory effects in squaric acid dibutyl ester (SADBE) induced ACD mice model, but the need for frequent administration stipulated by short half-life and low bioavailability limits clinical application.

Objective: To evaluate the analgesic and antipruritic effects of OMT gel (OG), OMT sustained release microgel powder (OMP) and OMT sustained release microgel cream (OMC) in SADBE induced ACD mice, with subsequent study of the mechanism and side effects (irritation) of optimal dosage form. Read More

Toxicol Res 2019 Oct 15;35(4):361-369. Epub 2019 Oct 15.

Department of Pharmacology, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, Korea.

1,2-Dichloropropane (1,2-DCP) has been used as an industrial solvent and a chemical intermediate, as well as in soil fumigants. Human exposure may occur during its production and industrial use. The target organs of 1,2-DCP are the eyes, respiratory system, liver, kidneys, central nervous system, and skin. Read More

BMC Complement Altern Med 2019 Oct 15;19(1):268. Epub 2019 Oct 15.

Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Long-term use of most immunosuppressants to treat allergic contact dermatitis (ACD) generates unavoidable severe side effects, warranting discovery or development of new immunosuppressants with good efficacy and low toxicity is urgently needed to treat this condition. Hispidulin, a flavonoid compound that can be delivered topically due to its favorable skin penetrability properties, has recently been reported to possess anti-inflammatory and immunosuppressive properties. However, no studies have investigated the effect of hispidulin on Th1 cell activities in an ACD setting. Read More

Ecotoxicol Environ Saf 2019 Dec 12;186:109772. Epub 2019 Oct 12.

Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Dermatology, Ministry of Education, Hefei, Anhui, China. Electronic address:

Trichloroethylene (TCE) is a common organic solvent which can cause TCE hypersensitivity syndrome (THS) in exposure workers. THS is an adverse skin disorder with severe inflammatory kidney damage. Complement C3a receptor (C3aR) acts as a specific receptor for the key complement cleavage product C3a and involves multiple inflammatory responses, but the role of C3aR in TCE induced kidney inflammatory injury remains unknown. Read More