Search Our Scientific Publications & Authors

Prostate Int 2018 Dec 1;6(4):157-161. Epub 2018 Jun 1.

Department of Urology, Yonsei University College of Medicine, Seoul, Korea.

Background: We investigated the usefulness of inflammatory markers including the delta neutrophil index (DNI), erythrocyte sedimentation rate, C-reactive protein, and procalcitonin as early predictors of sepsis in patients with acute prostatitis (AP). In addition, we evaluated the efficacy of intermittent catheterization for the initial management of acute urinary retention (AUR) in patients with AP.

Materials And Methods: All patients who presented to the emergency department and were admitted to the urology department from January 2011 to December 2013 were retrospectively reviewed. Read More

Top Companion Anim Med 2018 Dec 8;33(4):105-108. Epub 2018 Sep 8.

Dipartimento di Medicina Veterinaria (DiMeV), Section of Surgery and Obstetrics, University of Bari Aldo Moro, Italy. Electronic address:

In last years, following the increased canine life expectancy and the rising attention pet-owners devote to their animals, several authors have carried on investigations concerning new techniques to early identify canine prostatic disorders that might affect the dog's quality of life. Prostatic disorders often have an asymptomatic onset and their early diagnosis is difficult: hence, they are usually identified at an advanced stage, only. Traditionally, the diagnosis of prostatic disorders is based on noninvasive tools, such as transrectal and abdominal palpation, seminal or prostatic fluid evaluation, and urinalysis and imaging. Read More

Antiinflamm Antiallergy Agents Med Chem 2018 Nov 28. Epub 2018 Nov 28.

ASST Santi Paolo e Carlo - University of Milan, Via Antonio di Rudini 8, 20100 Milano. Italy.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is reported in literature ranging from 1 to 14.2%. The aim of the present study was to assess the impact on patient's quality of life and symptoms of Flower pollen extract in association with vitamins (Deprox 500®) in comparison with Serenoa repens 320 mg (Permixon 320 mg® by Pierre Fabre) in patients with CP/CPPS. Read More

Prostate 2018 Nov 28. Epub 2018 Nov 28.

Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul, Korea.

Background: Trichomonas vaginalis (T. vaginalis) is the most common sexually transmitted parasite. It has been detected in prostatic tissue of patients with prostatitis and reported to be associated with chronic prostatitis and benign prostatic hyperplasia as well as prostate cancer. Read More

Am J Mens Health 2018 Nov 28:1557988318814663. Epub 2018 Nov 28.

1 Department of Rehabilitation Medicine, the First Affiliated Hospital of China Medical University, Shenyang, China.

This study aims to determine the effect of radial extracorporeal shock wave therapy (rESWT) versus drug when treating chronic pelvic pain syndrome (CPPS; type III B chronic prostatitis). The study included 45 participants with CPPS, divided into two groups: Group I comprised 25 participants, who were treated with rESWT (3,000 pulses each; pressure: 1.8-2. Read More

Mol Med Rep 2018 Nov 21. Epub 2018 Nov 21.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Chronic non‑bacterial prostatitis (CNBP) is a common urinary disease and no standard treatments are available at present. Although autophagy serves an important role in a variety of chronic diseases, its role in CNBP is yet to be fully elucidated. Therefore, the present study aimed to investigate the effects of rapamycin‑induced autophagy on CNBP by establishing a rat model. Read More

Sci Rep 2018 Nov 27;8(1):17420. Epub 2018 Nov 27.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, United States.

Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common syndrome with limited therapies and an unknown etiology. Previously, our laboratory has defined a potential role for pathogenic infection in disease onset. Intra-urethral infection with a uropathogenic Escherichia coli strain isolated from a CP/CPPS patient, CP1, induces prostatic inflammation and tactile allodynia in mice. Read More

F1000Res 2018 9;7. Epub 2018 Nov 9.

Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Read More

Fundam Clin Pharmacol 2018 Nov 24. Epub 2018 Nov 24.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, China.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex disease of unclear etiology. Precise treatment of CP/CPPS is not available due to lack of specific cause; however, autoimmunity is the most valid theory. We develop a new treatment strategy that involves synthesis and coupling of biodegradable nanoparticles to antigenic T2 peptide to induce immune tolerance in CP/CPPS mice models. Read More

Lancet Oncol 2018 Nov 20. Epub 2018 Nov 20.

Service d'Imagerie Diagnostique et Interventionnelle de l'Adulte, CHU de Bordeaux, Université de Bordeaux, France.

Background: Whether multiparametric MRI improves the detection of clinically significant prostate cancer and avoids the need for systematic biopsy in biopsy-naive patients remains controversial. We aimed to investigate whether using this approach before biopsy would improve detection of clinically significant prostate cancer in biopsy-naive patients.

Methods: In this prospective, multicentre, paired diagnostic study, done at 16 centres in France, we enrolled patients aged 18-75 years with prostate-specific antigen concentrations of 20 ng/mL or less, and with stage T2c or lower prostate cancer. Read More

Biomed Pharmacother 2018 Dec 26;108:1894-1901. Epub 2018 Oct 26.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, School of Pharmacy, Jiangsu Province, Nanjing 211198, PR China; Department of Surgery, Nanjing Shuiximen Hospital, Jiangsu Province, Nanjing 210017, PR China; Department of Cardiothoracic Surgery, Zhongda Hospital affiliated to Southeast University, Jiangsu Province, Nanjing 210017, PR China. Electronic address:

Chronic prostatitis (CP) is a common disease in urology and can be develop in all age groups. It is more commonly seen in men over the age of 50. It's cure rate is low, the recurrence rate is high, the symptoms are complicated, the duration of disease is prolonged, the lingering is difficult to heal, the pain site is extensive and the associated symptoms are more, which bring great physical pain and mental burden to the patient. Read More

Prostate 2018 Nov 18. Epub 2018 Nov 18.

Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan, China.

Background: Benign prostate hyperplasia (BPH) is the most common disease among aging males, but no reports have addressed the prevalence of BPH in Zhengzhou. Therefore, we aimed to understand the prevalence of BPH in men aged 40 years or older in Zhengzhou's rural areas through a cross-sectional study and analyzed the correlation with epidemiologic factors and the heritability of the disease.

Materials And Methods: A multistage sampling method was used to randomly select male respondents in Zhengzhou's rural areas. Read More

Urologia 2018 Nov 4;85(4):150-157. Epub 2018 Apr 4.

1 Sechenov First Moscow State Medical University, Moscow, Russia.

Objective:: To identify risk factors for urethral stricture and/or bladder neck contracture after transurethral resection of benign prostatic hyperplasia.

Materials And Methods:: We performed a retrospective analysis of 402 patients, which underwent a monopolar transurethral resection of the prostate in the urology clinic of Sechenov First Moscow State Medical University for prostatic hyperplasia during the period 2011-2014. Urethral stricture and (or) bladder neck contracture in the postoperative period were diagnosed in 61 (15. Read More

AJR Am J Roentgenol 2018 Nov 7:1-6. Epub 2018 Nov 7.

1 Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637.

Objective: This study investigates the multiparametric MRI (mpMRI) characteristics and pathologic outcome of wedge-shaped lesions observed on T2-weighted images.

Materials And Methods: Seventy-six patients with histologically confirmed prostate cancer underwent preoperative 3-T MRI before undergoing radical prostatectomy. Two radiologists worked in consensus to mark wedge-shaped regions of hypointensity on T2-weighted images and assess their appearance on apparent diffusion coefficient (ADC) maps (to determine the degree of hypointensity) and dynamic contrast-enhanced (DCE) MRI (DCE-MRI) (to assess whether they showed early enhancement). Read More

Pathol Oncol Res 2018 Nov 6. Epub 2018 Nov 6.

Urology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

The initiation of prostatic malignancy has been linked to chronic inflammation. Stem cell factor (SCF) is an inflammatory cytokine that is specific to the c-KIT receptor which is type III receptor tyrosine kinase (RTK). Cyclooxygenases (COXs) are the main enzymes which are responsible for prostaglandins production from arachidonic acid. Read More

Invest Radiol 2018 Nov 2. Epub 2018 Nov 2.

From the Department of Radiology, University Hospital Jena, Jena, Germany.

Objectives: The aim of the study was to determine the quantitative T2 values in prostate tissue and evaluate them for detection and grading of prostate cancer.

Materials And Methods: After approval from the local ethics committee, morphological T2-weighted (T2w) images, apparent diffusion coefficient (ADC) maps from diffusion-weighted images, quantitative T2 maps, and calculated T2w images from 75 men (median age, 66.3 years; median PSA, 8. Read More

J Microbiol Methods 2018 Nov 26;154:124-126. Epub 2018 Oct 26.

Department of Clinical Pathology, Virology Unit, "San Giovanni di Dio e Ruggid'Aragona Hospital", Salerno, Italy.

The objective was to investigate the diagnostic accuracy of our microbiological protocol to simplify the evaluation of bacterial prostatitis in the clinical practice. Our findings show the possibility to apply our alternative enrichment semen culture method to detect prostatic bacterial infection with higher sensitivity than the gold standard M&S technique. Read More

Infect Dis (Lond) 2018 Oct 29:1-13. Epub 2018 Oct 29.

b General Medicine, University Hospital of Heraklion , Heraklion , Greece.

Background: Infectious complications after transrectal prostate biopsy are rare. Nevertheless, since these are frequent procedures, the burden of infectious complications is high. Considering the increasing antimicrobial resistance, microbiological confirmation is important to guide antimicrobial therapy. Read More

Oxf Med Case Reports 2018 Nov 17;2018(11):omy086. Epub 2018 Oct 17.

Teaching Hospital of Michigan State University, Beaumont Hospital, Farmington Hills, MI, USA.

Acute bacterial prostatitis, an acute infection of the prostate gland, results in lower abdominal pain, flank pain, urinary symptoms and the potential for systemic symptoms like fever and shock. With a high mortality rate if left untreated, acute bacterial prostatitis becomes a true urological emergency, which if allowed to progress, may result in bacteremia, severe sepsis/septic shock and death. Diagnosis is mainly clinical with a detailed history and physical and laboratory evaluation to include a urinalysis. Read More

Transl Androl Urol 2018 Sep;7(Suppl 4):S420-S435

Division of Surgery, Department of Surgery and Cancer, Imperial College London, London, UK.

Accurate diagnosis of clinically significant prostate cancer is essential in identifying patients who should be offered treatment with curative intent. Modifications to the Gleason grading system in recent years show that accurate grading and reporting at needle biopsy can improve identification of clinically significant prostate cancers. Extracapsular extension of prostate cancer has been demonstrated to be an adverse prognostic factor with greater risk of metastatic spread than organ-confined disease. Read More

Medicine (Baltimore) 2018 Oct;97(42):e12887

Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disorder. Some studies have indicated that acupuncture may ameliorate the symptoms of CP/CPPS. However, results are varied and range widely, perhaps due to different modes of assessment including timepoints, places of assessment, and especially subjective scales. Read More

Clin Nucl Med 2018 Dec;43(12):e484-e485

Primary prostatic calculi commonly present asymptomatically in men over the age of 50 years. Individual calculi form when the secretory tube is blocked by inflammation, prostatic secretions, or corpora amylacea. Although small prostatic calculi have been described as a component of normal aging, increased prevalence of calculi has been associated with benign prostatic hyperplasia and prostatitis. Read More

Mol Imaging Radionucl Ther 2018 Oct;27(3):133-135

University Hospital of Geneva, Clinic of Nuclear Medicine, Geneva, Switzerland

A 23-year-old African native male patient presented with fever, lumbalgia and dysuria after returning from a trip to Togo. His physical examination revealed pain over the pubic symphysis and rectal tenderness on digital exam. The C-reactive protein (CRP) level was elevated along with positive blood and urinary cultures for methicillin-resistant . Read More

Cancer Res Treat 2018 Oct 2. Epub 2018 Oct 2.

Department of Pathology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea.

Purpose: The purpose of this study was to determine whether histologic inflammation (HI) in initial and repeat prostate biopsy specimens was significantly associated with the detection of prostate cancer.

Materials And Methods: Between 2005 and 2017, the clinicopathological records of patients with high prostate-specific antigen (PSA) levels who underwent initial and repeat prostate biopsies were retrospectively reviewed. The presence of HI and its degree in each biopsied specimen were interpreted by one uropathologist with 20 years of experience. Read More

Res Rep Urol 2018 18;10:95-101. Epub 2018 Sep 18.

Physiotherapy Department, College of Medical and Health Sciences, Ahlia University, Manama, Kingdom of Bahrain,

Background: A significant number of men who are younger than 50 years visit urologists for interminable prostatitis. This study aimed to thoroughly investigate the effect of pumpkin seed oil (PSO) phonophoresis on chronic nonbacterial prostatitis (CNBP).

Subjects And Methods: Sixty patients with CNBP were randomly assigned to three groups: Group A, wherein patients were treated with PSO using phonophoresis; Group B, where patients underwent transperineal continuous low-intensity ultrasound (LIUS); and Group C, wherein patients underwent placebo LIUS. Read More

Res Rep Urol 2018 17;10:75-87. Epub 2018 Sep 17.

Andrology Center, Villa Benedetta Clinic, Rome, Italy,

This article focuses on the role that oxidative stress plays in chronic prostatitis, not only with respect to the known impact on symptoms and fertility but also especially in relation to possible prostate cancer development. Prostatitis is the most common urologic disease in adult males younger than 50 years and the third most common urologic diagnosis in males older than 50 years. If the germ-causing acute prostatitis is not eliminated, the inflammatory process becomes chronic. Read More

Eur Urol Focus 2018 Sep 27. Epub 2018 Sep 27.

Maastricht University Medical Centre, Maastricht, The Netherlands.

Context: Until 2012, the urinary tract of healthy individuals was considered to be sterile. The advent of metagenomic sequencing revealed a unique urinary microbiota (UM). This paradigm shift appears to have prolific implications in the etiology of several functional lower urinary tract (LUT) disorders. Read More

Dis Model Mech 2018 Nov 16;11(11). Epub 2018 Nov 16.

Departments of Urology, Medicine, Pathology & Cell Biology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA

Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlying processes are not well understood. Based on analysis of genetically engineered mouse models combined with correlative analysis of expression profiling data from human prostate tumors, we demonstrate a reciprocal relationship between inflammation and the status of the homeobox gene associated with prostate cancer initiation. We find that cancer initiation in aged mutant mice correlates with enrichment of specific immune populations and increased expression of immunoregulatory genes. Read More

Prostate 2018 Sep 21. Epub 2018 Sep 21.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Introduction: Chronic pelvic pain syndrome (CPPS) is a complex disorder that affects a large proportion of all men. A limited understanding of its etiology and pathogenesis is reflected by the absence of effective therapies. Although CPPS is deemed clinically non-infectious with no well-defined etiological role for microbes, bacteria is readily isolated from both healthy and patient prostate secretion and urine samples. Read More

Front Immunol 2018 3;9:1980. Epub 2018 Sep 3.

Centro de Microscopía Electrónica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Neutrophils are major effectors of acute inflammation against infection and tissue damage, with ability to adapt their phenotype according to the microenvironment. Although sex hormones regulate adaptive immune cells, which explains sex differences in immunity and infection, little information is available about the effects of androgens on neutrophils. We therefore aimed to examine neutrophil recruitment and plasticity in androgen-dependent and -independent sites under androgen manipulation. Read More

Radiology 2018 Oct;289(1):267-271

From the Departments of Radiology (A.D.d.L., D.N.C., I.P.), Urology (I.P.), and Pathology (F.F.), and the Advanced Imaging Research Center (D.N.C., I.P.), University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085.

History A 68-year-old man with a remote history of a previously resected high-grade urothelial carcinoma in the renal pelvis was being observed and was undergoing urologic treatment for recurrent low-grade urothelial carcinoma of the bladder. During his most recent evaluation, he reported no specific symptoms and denied experiencing hematuria, dysuria, or abdominal pain. At routine surveillance MRI of the abdomen and pelvis (images not shown), a lesion was noted in the peripheral zone of the prostate gland. Read More

Case Rep Urol 2018 29;2018:5417903. Epub 2018 Aug 29.

Urology B Department, Ibn Sina Teaching Hospital, Rabat, Morocco.

Xanthogranulomatous prostatitis is a rare benign inflammatory process of the prostate. Only few cases have been reported in the English literature. Xanthogranulomatous prostatitis is usually an incidental finding after needle biopsy or transurethral resection of the prostate in patients suffering from low urinary tract symptoms. Read More

J Urol 2018 Oct 7;200(4):679. Epub 2018 Jul 7.

J Phys Ther Sci 2018 Sep 4;30(9):1145-1149. Epub 2018 Sep 4.

Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University: Giza, Egypt.

[Purpose] This study aimed to evaluate the effect of radial extracorporeal shock wave therapy (rESWT) on patients with chronic pelvic pain syndrome (CPPS). [Participants and Methods] Forty male CPPS patients were randomly assigned into either an rESWT group or a control group. The first group was treated with rESWT two times per week for four weeks with a protocol 3,000 pulse, 12 Hz at 3 to 5 bar. Read More

Medicine (Baltimore) 2018 Sep;97(37):e12511

Eur Urol Focus 2018 Sep 8. Epub 2018 Sep 8.

Department of Urology, Glickman Urological and Kidney Institute, Cleveland, OH, USA. Electronic address:

Chronic prostatitis/chronic pelvic pain syndrome represents a wide range of clinical phenotypes and has traditionally been a diagnosis of exclusion with few proven remedies. Our structured, simplified approach to evaluation and management of this complex condition results in improved patient outcomes. Read More

Transpl Infect Dis 2018 Sep 11:e12998. Epub 2018 Sep 11.

Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, California.

We present a case of cytomegalovirus (CMV) native kidney nephritis and prostatitis in a CMV D+/R- kidney transplant recipient who had completed six months of CMV prophylaxis four weeks prior to the diagnosis of genitourinary CMV disease. The patient had a history of benign prostatic hypertrophy and urinary retention that required self-catheterization to relieve high post-voiding residual volumes. At 7 months post-transplant, he was found to have a urinary tract infection, moderate hydronephrosis of the transplanted kidney, and severe hydroureteronephrosis of the native left kidney and ureter, and underwent native left nephrectomy and transurethral resection of the prostate. Read More

Neurourol Urodyn 2018 Nov 6;37(8):2911-2918. Epub 2018 Sep 6.

Division of Urologic Surgery, Department of Surgery, St. Louis, Missouri.

Aims: To compare severity and characteristics of urologic pain, other urinary symptoms, sexual pain, psychosocial health, and the distribution and intensity of non-urologic pain between men and women with and without Hunner lesions.

Methods: All cystoscopies were performed and documented by the same clinician to ensure uniform recognition of Hunner lesions. Intensity of urologic and sexual pain, nocturia, frequency, urgency, and bladder hypersensitivity features were assessed using validated questionnaires and numeric rating scales. Read More

Hum Pathol 2018 Sep 1. Epub 2018 Sep 1.

Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Magnetic Resonance Imaging (MRI)/Ultrasound fusion-targeted biopsy (TB) has been shown to more accurately identify higher grade prostate cancers compared to standard-of-care systematic sextant prostate biopsy (SB). However, occasional false positive imaging findings occur. We investigated the histologic findings associated with false positive prostate MRI findings. Read More

Biom J 2018 Sep 3. Epub 2018 Sep 3.

Development, Astellas, Leiden, The Netherlands.

There is a need for identifying effective drugs or terminating ineffective drugs as early as possible to optimize efficient and cost effective drug development. The aim of the proposed trial was to simultaneously establish Proof of Concept (PoC) and dose finding (DF) for a new drug with a novel mode of action in a new indication. We simulated and executed an adaptive allocation design to investigate the effects of a drug on male patients suffering from chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Read More

Zhonghua Nan Ke Xue 2018 Jun;24(6):553-557

Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450008, China.

Objective: To know the basic status of researches on the mental health of prostatitis patients in China by statistical analysis of the literature published in the past two decades and provide some reference for such studies.

Methods: Using the bibliometrics method, we performed statistical analyses on the publication years, journals, and authors of the articles published in the core journals concerning the mental health of prostatitis patients in China as well as on the topics of the identified studies using their titles, key words and abstracts.

Results: Totally, 226 related studies were identified, of which 31 (by 29 authors) were published in the Chinese core journals. Read More

Zhonghua Nan Ke Xue 2018 Jun;24(6):491-498

Department of Andrology, Jinling Hospital Affiliated to Southern Medical University / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.

Objective: To investigate the effects of fosfomycin tromethamine (FT) on the expressions of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and interleukin-6 (IL-6) in the prostate tissue of the rats with chronic bacterial prostatitis (CBP).

Methods: We randomly divided 70 male SD rats into 7 groups of equal number: blank control, CBP model control, positive control, 14 d low-dose FT, 7 d low-dose FT, 14 d high-dose FT, and 7 d high-dose FT. The CBP model rats in the latter five groups were treated intragastrically with levofloxacin at 100 mg/kg/d for 30 days and FT at 200 mg/kg/d for 14 and 7 days and at 300 mg/kg/d for 14 and 7 days, respectively. Read More

Zhonghua Nan Ke Xue 2018 Jul;24(7):645-650

Department of Andrology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.

Mycoplasma genitalium (MG) was first isolated by Tully from the urinary tract of the male patient with non-gonococcal urethritis (NGU) in 1981. MG is extremely difficult to be cultured and was rarely studied until the development and application of molecular biology technology. The research on MG in China is still in the primary stage. Read More

Zhonghua Nan Ke Xue 2018 Jul;24(7):640-644

Department of Integrated Chinese and Western Medicine, Jiangsu Health Vocational College, Nanjing, Jiangsu 210029, China.

Objective: To evaluate the efficiency and safety of № I Empirical Prescription for Chronic Prostatitis (№ I EPCP) in the treatment of type Ⅲ refractory chronic prostatitis.

Methods: We randomly assigned 53 cases of type Ⅲ refractory chronic prostatitis with damp-heat and blood stasis to an experimental and a control group to receive № I EPCP at 1 dose per day and saw palmetto extract at 160 mg bid), respectively, all for 8 weeks. Before and after 4 and 8 weeks of treatment, we obtained The National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores, Traditional Chinese Medicine Syndrome Scores (TCMSS), maximum urinary flow rate (Qmax), average urinary flow rate (Qavg), Hamilton Depression Rating Scale (HAMD) scores and Hamilton Anxiety Rating Scale (HAMA) scores, and compared them between the two groups of patients. Read More

J Small Anim Pract 2018 Nov 31;59(11):719. Epub 2018 Aug 31.

Wyndham Veterinary Clinic, Werribee, Victoria 3030, Australia.

Curr Urol Rep 2018 Aug 31;19(11):88. Epub 2018 Aug 31.

Department of Urology, Weill Cornell Medical College/New York Presbyterian, New York, NY, 10065, USA.

Purpose Of Review: To review the most up-to-date diagnosis and treatment of chronic prostatitis. We conducted a review of the literature based on the diagnosis and treatment of chronic prostatitis.

Recent Findings: The use of advanced phenotyping, links to lifestyle, and multimodal approaches has helped to enhance the treatment of chronic prostatitis and its negative effects on quality of life. Read More

Environ Pollut 2018 Nov 17;242(Pt B):1535-1545. Epub 2018 Aug 17.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China. Electronic address:

Microcystin-leucine-arginine (MC-LR), as a most common and deleterious variant among all structural analogues of Microcystins (MCs), can cause male reproductive dysfunction. However, its toxic effects on prostate in adult mice have not been invested in detail. In this study, we observed that MC-LR could enter prostate tissues and induce focal hyperplasia and prostate inflammation. Read More

Int Urol Nephrol 2018 Nov 24;50(11):1963-1973. Epub 2018 Aug 24.

School of Pharmacy, Fudan University, Shanghai, 201203, China.

Purpose: Folic acid (FA) intake has increased to high levels in many countries for the prevention of neural tube defects. However, the impact of excess FA intake, particularly before and during pregnancy, requires further investigation. Our aim was to investigate the effect of maternal folic acid supplementation on prostatitis risk in the rat offspring. Read More

Medicine (Baltimore) 2018 Aug;97(33):e11840

Shanghai HaiTian Pharmaceutical Science & Technology Development Co., Ltd. Shanghai, China.

Background: To evaluate the efficacy and safety of Ningmitai (NMT) capsule for treating chronic prostatitis (CP) in China.

Methods: Retrieving the China Journal Full-Text Database (CNKI), Wanfang database, China's outstanding master's/doctoral dissertation database, VIP Science and Technology Periodical Database, Cochrane library, PubMed, Embase, and Chinese academic conference papers. Collecting and selecting literatures of randomized controlled trials before March 2017 on NMT capsule for CP, evaluated by Jadad scale, and then analyzed with Stata software. Read More

BMJ Case Rep 2018 Aug 14;2018. Epub 2018 Aug 14.

Division of Rheumatology, Department of Medicine, Albany Medical Center, Albany, New York, USA.

A previously healthy 21-year-old man presented with an 8-month history of weight loss, lethargy and dysuria unresponsive to empiric antibiotics and paraurethral drainage of a prostatic abscess. Urinalysis showed pyuria, but cultures failed to grow any organisms. Additionally, he developed new onset sensorineural hearing loss. Read More