251 results match your criteria Prostatitis Nonbacterial


[Rationale of use and effectiveness of Longidaza in patients with chronic prostatitis].

Urologiia 2018 Oct(4):64-71

Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia, Novosibirsk, Russia.

Introduction: Chronic inflammation of the prostate leads to the formation of excess fibrous connective tissue, which hinders patients recovery and aggravates the symptoms.

Aim: This study aimed to confirm the correlation between inflammation and prostatic fibrosis and the abnormalities of urodynamic and microcirculation in the prostate gland in humans, and the possibility of increasing the effectiveness of treatment of patients with chronic nonbacterial prostatitis using antisclerotic therapy.

Material And Methods: The study was carried out in two stages. Read More

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October 2018

The Effects of Korea Red Ginseng on Inflammatory Cytokines and Apoptosis in Rat Model with Chronic Nonbacterial Prostatitis.

Biomed Res Int 2019 14;2019:2462561. Epub 2019 Jan 14.

Department of Biomedical Laboratory Science, Catholic Kwandong University, Gangneung, Republic of Korea.

Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. Read More

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https://www.hindawi.com/journals/bmri/2019/2462561/
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http://dx.doi.org/10.1155/2019/2462561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348920PMC
January 2019
1 Read

[Immediate and long-term effectiveness of combined application of magnetolaser therapy and red light in complex treatment of patients with chronic nonbacterial prostatitis].

Urologiia 2018 Dec(6):101-106

Department of Polyclinic Therapy and Medical Rehabilitation with the course of Additional Professional Education Federal State Educational Institution of Higher Education Altai State Medical University of the Ministry of Health of the Russian Federation, Barnaul, Russia.

The aim of the study was to increase the efficiency of complex treatment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with the combined effect of magnetolaser therapy (MLT) and red light.

Materials And Methods: We examined and included in the study 120 men with a verified diagnosis of CP/CPPS (III B), at the stage of exacerbation. By envelope method, patients were divided into two randomized groups. Read More

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December 2018
1 Read

MicroRNA expression profile in chronic nonbacterial prostatitis revealed by next-generation small RNA sequencing.

Asian J Androl 2018 Dec 25. Epub 2018 Dec 25.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

MicroRNAs (miRNAs) are considered to be involved in the pathogenic initiation and progression of chronic nonbacterial prostatitis (CNP); however, the comprehensive expression profile of dysregulated miRNAs, relevant signaling pathways, and core machineries in CNP have not been fully elucidated. In the current research, CNP rat models were established through the intraprostatic injection of carrageenan into the prostate. Then, next-generation sequencing was performed to explore the miRNA expression profile in CNP. Read More

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http://dx.doi.org/10.4103/aja.aja_97_18DOI Listing
December 2018
4 Reads

Implications of prostate inflammation on male fertility.

Andrologia 2018 Dec;50(11):e13093

Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.

The prostate is the seat of three major causes of morbidity: benign prostatic hyperplasia, prostate cancer and prostatitis, three conditions in which inflammation has been implicated. A state of inflammation of the prostate gland, originally incited by an infection, an autoimmune response, a neurogenic stimulus or another trigger may have consequences on prostate functionality. In fact, male fertility depends intrinsically on the content of prostatic fluid factors secreted by the prostatic epithelium. Read More

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http://dx.doi.org/10.1111/and.13093DOI Listing
December 2018
4 Reads

Voiding behavior and chronic pelvic pain in two types of rat nonbacterial prostatitis models: Attenuation of chronic pelvic pain by repeated administration of tadalafil.

Prostate 2019 Apr 14;79(5):446-453. Epub 2018 Dec 14.

Research Laboratories, Nippon Shinyaku Co., Ltd., Minami-ku, Kyoto, Japan.

Background: Experimental autoimmune prostatitis (EAP) and prostatitis induced by 17β-estradiol treatment combined with castration (hormone/castration-induced prostatitis; HCP) are the most commonly used rodent models of nonbacterial prostatitis. We studied the effect of the phosphodiesterase 5 inhibitor tadalafil on chronic pelvic pain in two such models in rats.

Methods: EAP was induced by intradermal injection of rat prostate antigen and complete Freund's adjuvant on Days 0 and 28. Read More

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http://dx.doi.org/10.1002/pros.23750DOI Listing
April 2019
1 Read

Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome‑mediated inflammation.

Mol Med Rep 2019 Jan 21;19(1):221-230. Epub 2018 Nov 21.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Chronic non‑bacterial prostatitis (CNBP) is a common urinary disease and no standard treatments are available at present. Although autophagy serves an important role in a variety of chronic diseases, its role in CNBP is yet to be fully elucidated. Therefore, the present study aimed to investigate the effects of rapamycin‑induced autophagy on CNBP by establishing a rat model. Read More

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http://dx.doi.org/10.3892/mmr.2018.9683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297772PMC
January 2019
1 Read

Trans-perineal pumpkin seed oil phonophoresis as an adjunctive treatment for chronic nonbacterial prostatitis.

Res Rep Urol 2018 18;10:95-101. Epub 2018 Sep 18.

Physiotherapy Department, College of Medical and Health Sciences, Ahlia University, Manama, Kingdom of Bahrain,

Background: A significant number of men who are younger than 50 years visit urologists for interminable prostatitis. This study aimed to thoroughly investigate the effect of pumpkin seed oil (PSO) phonophoresis on chronic nonbacterial prostatitis (CNBP).

Subjects And Methods: Sixty patients with CNBP were randomly assigned to three groups: Group A, wherein patients were treated with PSO using phonophoresis; Group B, where patients underwent transperineal continuous low-intensity ultrasound (LIUS); and Group C, wherein patients underwent placebo LIUS. Read More

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https://www.dovepress.com/trans-perineal-pumpkin-seed-oil-ph
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http://dx.doi.org/10.2147/RRU.S167896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149936PMC
September 2018
22 Reads

Chronic pelvic pain and prostate inflammation in rat experimental autoimmune prostatitis: Effect of a single treatment with phosphodiesterase 5 inhibitors on chronic pelvic pain.

Prostate 2018 Nov 15;78(15):1157-1165. Epub 2018 Jul 15.

Research Laboratories, Nippon Shinyaku Co., Ltd., Minami-ku, Kyoto, Japan.

Background: Experimental autoimmune prostatitis (EAP) is most often used as a nonbacterial model of chronic prostatitis/chronic pelvic pain. We investigated the development of chronic pelvic pain and inflammatory changes in rat EAP and examined the effect of a single treatment with phosphodiesterase 5 (PDE5) inhibitors on the chronic pelvic pain.

Methods: EAP was induced in rats by intradermal injection of rat prostate antigen and complete Freund's adjuvant on days 0 and 28. Read More

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http://dx.doi.org/10.1002/pros.23690DOI Listing
November 2018
4 Reads

Neurologic Mechanisms Underlying Voiding Dysfunction due to Prostatitis in a Rat Model of Nonbacterial Prostatic Inflammation.

Int Neurourol J 2018 Jun 30;22(2):90-98. Epub 2018 Jun 30.

Department of Urology, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The neurological molecular mechanisms underlying the voiding dysfunction associated with nonbacterial chronic prostatitis/chronic pelvic pain syndrome remain poorly understood. In this study, we assessed whether prostate inflammation activated bladder afferent neurons, leading to bladder dysfunction, and sought to elucidate the underlying mechanisms.

Methods: Thirty male Sprague-Dawley rats were divided into 3 groups: sham-saline, formalin-injected, and capsaicin-pretreated and formalin-injected. Read More

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http://einj.org/journal/view.php?doi=10.5213/inj.1836124.062
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http://dx.doi.org/10.5213/inj.1836124.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059909PMC
June 2018
11 Reads

Treatment of refractory category III nonbacterial chronic prostatitis/chronic pelvic pain syndrome with intraprostatic injection of onabotulinumtoxinA: a prospective controlled study.

Can J Urol 2018 04;25(2):9273-9280

Department of Urology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Introduction: To evaluate the efficacy and safety of intraprostatic injections of onabotulinumtoxinA (onaBoNT-A) to treat refractory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Materials And Methods: Prospective two-group controlled study. Treatment group included adult men with refractory category-III nonbacterial CP/CPPS who underwent transurethral intraprostatic injections of onaBoNT-A (200 U). Read More

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April 2018
5 Reads

Rapamycin Alleviates Hormone Imbalance-Induced Chronic Nonbacterial Inflammation in Rat Prostate Through Activating Autophagy via the mTOR/ULK1/ATG13 Signaling Pathway.

Inflammation 2018 Aug;41(4):1384-1395

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Chronic prostatitis (CP) is a clinically common disease with high morbidity. It affects the patients' quality of life (QoL) as well as physical and mental health seriously due to the recurring symptoms of lower urinary tract and genitalia. As the opinions about the etiology of CP are still not uniform, it is very difficult to be treated or even cured. Read More

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http://link.springer.com/10.1007/s10753-018-0786-7
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http://dx.doi.org/10.1007/s10753-018-0786-7DOI Listing
August 2018
7 Reads

Experimental Analysis of the Efficacy of Dihydroquercetin on the Model of Chronic Nonbacterial Inflammation of the Prostatic Gland.

Bull Exp Biol Med 2018 Mar 26;164(5):617-619. Epub 2018 Mar 26.

Tomsk Research Institute of Oncology, Tomsk National Medical Research Center, Tomsk, Russia.

We studied the efficiency of dihydroquercetin on the model of chronic nonbacterial inflammation of the prostatic gland in rats. It was found that administration of dihydroquercetin was followed by a significant decrease in the area of the connective tissue in the prostatic gland to initial levels, which attested to antifibrotic properties of this oxidant. Additionally, the substance prevented the development of atrophy of acinus epithelium. Read More

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http://dx.doi.org/10.1007/s10517-018-4044-7DOI Listing
March 2018
4 Reads

Pentoxifylline mitigates detrimental impact of chronic nonbacterial prostatitis on sperm characteristics, reproductive hormones and histopathology in rats.

Andrologia 2018 Apr 18;50(3). Epub 2017 Dec 18.

Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

The protective role of pentoxifylline (PTX) on sperm characteristics, reproductive hormones and histopathology following carrageenan-induced chronic nonbacterial prostatitis (CNP) was investigated in male Wistar rats. Thirty-six rats were grouped into six rats per group. Group 1 (control) received saline normal. Read More

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http://dx.doi.org/10.1111/and.12932DOI Listing
April 2018
4 Reads

[The effect of drug oil moxibustion for contents of Zinc and C-reactive protein in succus prostaticus of chronic nonbacterial prostatitis].

Zhongguo Zhen Jiu 2017 Aug;37(8):840-844

Urological Department, Chuzhou Integrated Hospital of Chinese and Western Medicine, Affiliated to Anhui University of CM, Chuzhou 239000, China.

Objective: To observe the clinical effects differences and partial mechanism for chronic nonbacterial prostatitis (CNP) among drug oil moxibustion, simple moxibustion, and conventional western medicine.

Methods: A total of 120 patients who met the criteria of inclusion were randomly assigned into a drug oil moxibustion group, a moxibustion group and a western medication group, 40 cases in each one. Moxibustion was used at Guanyuan (CV 4), Zhongji (CV 3), Qihai (CV 6) and bilateral Yinlingquan (SP 9), Sanyinjiao (SP 6), Shenshu (BL 23), Mingmen (GV 4), Pangguangshu (BL 28), Ciliao (BL 32), and Zhibian (BL 54), etc. Read More

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http://dx.doi.org/10.13703/j.0255-2930.2017.08.011DOI Listing
August 2017
5 Reads

[General clinical and laboratory and instrumental characteristics of the chronic nonbapterial prostatite with the inflammatory component in men of the first period of mature age].

Urologiia 2017 Oct(5):36-41

Voino-Yasenetsky Krasnoyarsk State Medical University of Minzdrav of Russia, Krasnoyarsk, Russia.

Aim: To investigate the course of CNPIC in young men treated with general and local ozone therapy.

Materials And Methods: 306 patients underwent standard treatment concurrently with local and systemic ozone therapy. Clinical-laboratory and instrumental parameters were evaluated before and after treatment. Read More

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October 2017
6 Reads

Hwanglyunhaedok Pharmacopuncture versus Saline Pharmacopuncture on Chronic Nonbacterial Prostatitis/Chronic Pelvic Pain Syndrome.

J Acupunct Meridian Stud 2017 Aug 13;10(4):245-251. Epub 2017 Jun 13.

Wonkwang University Oriental Medical School, Department of Internal Medicine, Jeonbuk, Republic of Korea; Department of Internal Medicine, Wonkwang University Medical Center, Gwangju, Republic of Korea. Electronic address:

Purpose: Chronic nonbacterial prostatitis (CP)/chronic pelvic pain syndrome (CPPS) is known not to have a successful therapy as yet. More recently, acupuncture, some herbal compounds, and trigger point injection have been reported to be beneficial. Pharmacopuncture is an herbal acupuncture having these benefits. Read More

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http://dx.doi.org/10.1016/j.jams.2017.06.001DOI Listing
August 2017
5 Reads

Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway.

Biochem Biophys Res Commun 2017 11 24;493(1):794-799. Epub 2017 Aug 24.

Department of Emergency, People's Hospital of Tiantai, Tiantai, PR China; Department of General Practice, People's Hospital of Tiantai, Tiantai, PR China; Department of Hepatopancreatic and Microinvasive Surgery, Zhejiang Provincial People's Hospital, Hangzhou, PR China.

Prostatitis is one of the most prevalent problems in andriatry and urinary surgery. In the present study, we evaluated the effect of procyanidin B2 (PB) on carrageenan-induced chronic nonbacterial prostatitis in rats. Results showed that PB significantly decreased the prostatic index and enhanced the body weight inhibited by carrageenan. Read More

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http://dx.doi.org/10.1016/j.bbrc.2017.08.089DOI Listing
November 2017
6 Reads

Evaluation of the protective effect of pentoxifylline on carrageenan-induced chronic non-bacterial prostatitis in rats.

Inflammopharmacology 2017 Jun 9;25(3):343-350. Epub 2017 Mar 9.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Chronic non-bacterial prostatitis (CNP) is the most common type of prostatitis and oxidative stress (OS) was shown to be highly elevated in prostatitis patients. This study aimed to investigate the protective effect of pentoxifylline (PTX) on CNP induced by carrageenan in rats. Male adult Wistar rats (n = 30) were divided into control, CNP and three treatment groups (n = 6) including CNP + cernilton and CNP + PTX groups. Read More

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http://dx.doi.org/10.1007/s10787-017-0335-2DOI Listing
June 2017
23 Reads

Effects of Estrogen Receptor β Stimulation in a Rat Model of Non-Bacterial Prostatic Inflammation.

Prostate 2017 May 9;77(7):803-811. Epub 2017 Feb 9.

Department of Urology, Oita University Graduate School of Medicine, Yufu, Japan.

Background: There is increasing evidence showing that chronic non-bacterial prostatic inflammation is involved in the pathogenesis of benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS). It has also been reported that estrogen receptor β (ERβ) could have an immunoprotective role in prostatic tissue. Therefore, we investigated the effect of ERβ-activation on not only prostatic inflammation, but also bladder overactive conditions in a rat model with nonbacterial prostatic inflammation. Read More

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http://dx.doi.org/10.1002/pros.23320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968815PMC
May 2017
13 Reads

Exercise Is Effective Therapy for Chronic Nonbacterial Prostatitis and Chronic Pelvic Pain Syndrome.

Authors:
James Meyers

Am Fam Physician 2016 10;94(7):533

La Verne, CA, USA.

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October 2016
3 Reads

The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate.

Naunyn Schmiedebergs Arch Pharmacol 2017 Feb 1;390(2):197-205. Epub 2016 Dec 1.

Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

There is no standard treatment of chronic nonbacterial prostatitis in humans. The current study was aimed to investigate the effect of montelukast, an antagonist of cysteinyl leukotriene receptor-1, against estrogen-induced, nonbacterial lateral lobe-specific prostate inflammation in rats. Male Wistar rats were randomized into five groups of six rats, including sham controls (group 1) and castrated rats (group 2), whereas nonbacterial prostatitis (NBP) was induced in groups 3-5 by castration followed by a daily subcutaneous injection of estradiol (0. Read More

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http://dx.doi.org/10.1007/s00210-016-1325-4DOI Listing
February 2017
12 Reads

Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2016 Dec 10;160(4):559-565. Epub 2016 Nov 10.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.

Background And Objectives: Recently, we described an inverse association between cranberry supplementation and serum prostate specific antigen (PSA) in patients with negative biopsy for prostate cancer (PCa) and chronic nonbacterial prostatitis. This double blind placebo controlled study evaluates the effects of cranberry consumption on PSA values and other markers in men with PCa before radical prostatectomy.

Methods: Prior to surgery, 64 patients with prostate cancer were randomized to a cranberry or placebo group. Read More

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http://dx.doi.org/10.5507/bp.2016.056DOI Listing
December 2016
5 Reads

Effect of Tripterygium Wilfordii Polyglycoside on Experimental Prostatitis Caused by Ureaplasma Urealyticum in Rats.

Med Sci Monit 2016 Oct 15;22:3722-3726. Epub 2016 Oct 15.

Department of Clinical Laboratory, Shaoxing County Central Hospital, Shaoxing, Zhejiang, China (mainland).

BACKGROUND Prostatitis is a common and refractory urological disease with complicated etiology. Ureaplasma urealyticum (UU) has a close relationship with human urinary tract infection that can induce nonbacterial prostatitis. Tripterygium wilfordii polyglycoside (TWP) is a non-steroidal immune inhibitor that causes significant immune suppression and anti-inflammatory effects. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070633PMC
October 2016
9 Reads

Transrectal microwave thermotherapy causing a short-time influence on sperm quality in Chinese chronic nonbacterial prostatitis patients.

Asian J Androl 2017 Sep-Oct;19(5):548-553

Department of Urology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA.

Chronic prostatitis can affect the sperm's quality. Previous studies have shown that transrectal microwave thermotherapy (TRMT) results in symptomatic relief in patients with chronic prostatitis, but the effects on sperm have not been carefully investigated. This study evaluates the impact of TRMT on the relief or decrease of symptoms and quality of sperm when used to treat patients with chronic nonbacterial prostatitis. Read More

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http://dx.doi.org/10.4103/1008-682X.185852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566848PMC
May 2018
33 Reads

[Expressions of SP and NK-1R increase in the posterior horn of the L5-S2 spinal cord in rats with chronic nonbacterial prostatitis].

Zhonghua Nan Ke Xue 2016 Jul;22(7):602-607

Department of Basic Medical Science, Pingdingshan College, Pingdingshan, Henan 467000, China.

Objective: To investigate the expressions of substance P (SP) and neurokinin-1 receptor (NK-1R) in the posterior horn of the L5-S2 spinal cord in the rat model of chronic nonbacterial prostatitis (CNP) at different time points of modeling.

Methods: Forty adult male SD rats were randomly divided into four groups of equal number, control, 45 d model, 60 d model, and 90 d model, and proteins were obtained from the prostatic tissue of another 30 rats. The CNP model was made by intraperitoneal injection of 0. Read More

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July 2016
14 Reads

An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men.

BMC Urol 2016 Jun 8;16(1):25. Epub 2016 Jun 8.

Departmentt of Urology, Humanitas Mater Domini, Via Gerenzano 2, I - 21053, Castellanza, Varese, Italy.

Background: Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90-95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can deteriorate quality of life. The purpose of this study was to observe the efficacy and safety of beclomethasone dipropionate rectal suppositories (Topster®) in inflammations of the lower urinary tract in men. Read More

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http://dx.doi.org/10.1186/s12894-016-0144-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897870PMC
June 2016
21 Reads

[Reduced zinc concentration in expressed prostatic secretion relates to the pain symptoms of types Ⅲ and Ⅳ prostatitis].

Zhonghua Nan Ke Xue 2016 Jun;22(6):496-500

Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

Objective: To determine the zinc levels in the expressed prostatic secretion (EPS) of the patients with different types of chronic nonbacterial prostatitis, and explore the reference value of zinc concentration in EPS in the diagnosis and treatment of prostatitis.

Methods: We collected EPS samples from 35 healthy men and 173 patients with chronic nonbacterial prostatitis, including 65 cases of type ⅢA, 69 cases of type ⅢB, and 39 cases of type Ⅳ, according to the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). We compared the zinc levels in the EPS samples among different groups and analyzed the correlations of zinc concentration with the NIH-CPSI scores, WBC count, pH value, and age of the subjects. Read More

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June 2016
26 Reads

N-acetylcysteine Ameliorates Prostatitis via miR-141 Regulating Keap1/Nrf2 Signaling.

Inflammation 2016 Apr;39(2):938-47

Reproductive Medicine Center, The First Affiliated Hospital of Soochow University, No.188, Shizi St, Canglang District, Suzhou, Jiangsu, 215006, China.

Chronic prostatitis was the most common type of prostatitis and oxidative stress was reported to be highly elevated in prostatitis patients. In this study, we determined the effect of N-acetylcysteine (NAC) on prostatitis and the molecular mechanism involved in it. Male Sprague-Dawley rats were divided into three groups: control group (group A, n = 20), carrageenan-induced chronic nonbacterial prostatitis (CNP) model group (group B, n = 20), and carrageenan-induced CNP model group with NAC injection (group C, n = 20). Read More

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http://dx.doi.org/10.1007/s10753-016-0327-1DOI Listing
April 2016
22 Reads

Common Questions About Chronic Prostatitis.

Am Fam Physician 2016 Feb;93(4):290-6

University of British Columbia, Vancouver, British Columbia, Canada.

Chronic prostatitis is relatively common, with a lifetime prevalence of 1.8% to 8.2%. Read More

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http://www.aafp.org/afp/2016/0215/p290.pdf
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February 2016
23 Reads

Investigation of the effect of traditional Chinese medicine on pain and inflammation in chronic nonbacterial prostatitis in rats.

Andrologia 2016 Aug 3;48(6):714-22. Epub 2016 Feb 3.

Department of Occupational Disease, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumuqi, China.

According to traditional Chinese medicine, the symptoms of chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CNP/CPPS) may be treated using a cocktail of herbs that stimulate blood circulation ('activating blood circulation formula'). We investigated the effect of three doses of this formula on a rat model of CNP/CPPS. Male Wistar rats were injected with a saline extract of male sex accessory glands on days 0 and 30 to induce prostatitis and then treated daily by gavage between days 32 and 60. Read More

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http://dx.doi.org/10.1111/and.12544DOI Listing
August 2016
6 Reads

[Effect of Qianlean Pill on IL-1β, IL-10, and TNF-α in Prostate Tissues of Chronic Nonbacterial Prostatitis Rats].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2015 Oct;35(10):1223-7

Objective: To observe the effect of Qianliean Pill (QP) on inflammatory factors such as IL-1β, IL-10, and tumor necrosis factor α (TNF-α) in chronic nonbacterial prostatitis (CNP) model rats, and to explore its therapeutic mechanism.

Methods: CNP rat model was established by castration and estradiol benzoate injection. Totally 50 rats were randomly divided into 5 groups, i. Read More

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October 2015
5 Reads

[IS A NONBACTERIAL PROSTATITIS NONBACTERIAL?].

Urologiia 2015 Jul-Aug(4):102-6

The study involved 287 patients with chronic recurrent urethroprostatitis. In 83 (28.9%) of them the bacterial microflora in prostatic secretions was detected. Read More

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December 2015
3 Reads

[PATHOGENETIC TREATMENT OF CHRONIC NONBACTERIAL PROSTATITIS COMPLICATED BY SPERM DISORDERS].

Urologiia 2015 Jul-Aug(4):64-6, 68-70

This study examines the efficacy and safety of the natural complex of multi-component biologically active dietary supplement Prostatinol in the pathogenetic treatment of 45 patients with chronic nonbacterial Prostatitis complicated by sperm disorders. Within 4 weeks 25 patients of the treatment group and 20 patients of the control group received Prostatinol or traditional anti-inflammatory therapy correspondingly. The results were evaluated at weeks 4 and 12 after treatment cessation. Read More

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December 2015
5 Reads

Eviprostat has an identical effect compared to pollen extract (Cernilton) in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized, prospective study.

BMC Urol 2015 Dec 7;15:120. Epub 2015 Dec 7.

Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, Aomori, 036-8562, Japan.

Background: Previously reported results of a prospective, randomized placebo-controlled study showed that the pollen extract (Cernilton) significantly improved total symptoms, pain, and quality of life in patients with inflammatory prostatitis/chronic pelvic pain syndrome (CP/CPPS) without severe side effects. A phytotherapeutic agent, Eviprostat, is reportedly effective in a rat model of nonbacterial prostatitis. The aim of the present study was to compare the efficacy and safety of Eviprostat to that of the pollen extract in the management of CP/CPPS. Read More

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http://dx.doi.org/10.1186/s12894-015-0115-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672535PMC
December 2015
25 Reads

Chronic Prostatitis: A Possible Cause of Hematospermia.

Authors:
Gilho Lee

World J Mens Health 2015 Aug 19;33(2):103-8. Epub 2015 Aug 19.

Department of Urology, Dankook University Medical College, Cheonan, Korea.

Purpose: While hematospermia is mainly caused by genitourinary inflammatory disorders, very few studies have been published on prostatitis-associated hematospermia (PAH) diagnosed using robust prostatitis evaluation methods. Therefore, we have evaluated the incidence of PAH by using systematic methods for evaluating prostatitis.

Materials And Methods: We evaluated 37 hematospermia patients from a single hospital over the last five years. Read More

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http://wjmh.org/Synapse/Data/PDFData/2074WJMH/wjmh-33-103.pd
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http://synapse.koreamed.org/DOIx.php?id=10.5534/wjmh.2015.33
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http://dx.doi.org/10.5534/wjmh.2015.33.2.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550592PMC
August 2015
1 Read

Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis.

Food Funct 2015 Nov 24;6(11):3540-9. Epub 2015 Aug 24.

National TCM Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China.

Limonin has been found to possess significant anti-inflammatory properties in animal tests and with, human cells, however, its precise metabolism mechanism has not been well explored. The aim of this study was to investigate the anti-inflammatory effects of limonin in a nonbacterial prostatitis (NBP) animal model. Global metabolite profiling was performed by ultra-high-performance liquid chromatography combined with time-of-flight mass spectrometry (UPLC/ESI-TOFMS) and in conjunction with multivariate data analysis and pathway analysis which were integrated to explore differentiating metabolites and clarify the mechanism of limonin against capsaicin-induced NBP. Read More

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http://dx.doi.org/10.1039/c5fo00489fDOI Listing
November 2015
8 Reads
2 Citations
2.791 Impact Factor

Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis.

Evid Based Complement Alternat Med 2015 3;2015:687196. Epub 2015 May 3.

Department of Biostatistics, Medical Faculty, Trakya University, Balkan Campus, 22030 Edirne, Turkey.

This research aimed to compare anti-inflammatory effects of oligonol, acupuncture, and quantum light therapy in rat models of estrogen-induced prostatitis. Adult male Wistar albino rats were grouped as follows: Group I, control (n = 10); Group II, chronic prostatitis (n = 10); Group III, oligonol (n = 10); Group IV, acupuncture (n = 10); Group V, quantum (n = 10); Group VI, oligonol plus quantum (n = 10); Group VII, acupuncture plus oligonol (n = 10); Group VIII, quantum plus acupuncture (n = 10); and Group IX, acupuncture plus quantum plus oligonol (n = 10). Chronic prostatitis (CP) was induced by the administration of 17-beta-estradiol (E2) and dihydrotestosterone (DHT). Read More

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http://dx.doi.org/10.1155/2015/687196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433713PMC
June 2015
11 Reads

Analgesic effects of oligonol, acupuncture and quantum light therapy on chronic nonbacterial prostatitis.

Iran Red Crescent Med J 2015 Apr 25;17(4):e26006. Epub 2015 Apr 25.

Department of Internal Medicine and Angiology, Wuppertal Research and Medical Center, Wuppertal, Germany.

Background: Chronic Nonbacterial Prostatitis (CNBP) is a condition that frequently causes long-term pain and a significant decrease in the quality of life.

Objectives: The present study aimed to examine the analgesic effects of oligonol, acupuncture, quantum light therapy and their combinations on estrogen-induced CNBP in rats.

Materials And Methods: This experimental study was conducted in Edirne, Turkey, using a simple randomized allocation. Read More

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http://dx.doi.org/10.5812/ircmj.17(4)2015.26006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443389PMC
April 2015
6 Reads

Serum quantitative proteomic analysis reveals potential zinc-associated biomarkers for nonbacterial prostatitis.

Prostate 2015 Oct 22;75(14):1538-55. Epub 2015 May 22.

Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Background: Prostatitis is one of the most common urological problems afflicting adult men. The etiology and pathogenesis of nonbacterial prostatitis, which accounts for 90-95% of cases, is largely unknown. As serum proteins often indicate the overall pathologic status of patients, we hypothesized that protein biomarkers of prostatitis might be identified by comparing the serum proteomes of patients with and without nonbacterial prostatitis. Read More

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http://dx.doi.org/10.1002/pros.23028DOI Listing
October 2015
19 Reads

Nociceptive and inflammatory mediator upregulation in a mouse model of chronic prostatitis.

Pain 2015 Aug;156(8):1537-44

Department of Anesthesiology, Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Chronic nonbacterial prostatitis, characterized by genitourinary pain in the pelvic region in the absence of an identifiable cause, is common in adult males. Surprisingly, the sensory innervation of the prostate and mediators that sensitize its innervation have received little attention. We thus characterized a mouse model of chronic prostatitis, focusing on the prostate innervation and how organ inflammation affects gene expression of putative nociceptive markers in prostate afferent somata in dorsal root ganglia (DRG) and mediators in the prostate. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000000201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260933PMC
August 2015
2 Reads

Ultrastructural Analysis of the Prostate Gland under the Effect of Factors of Chemical Industry.

Bull Exp Biol Med 2015 Apr 23;158(6):827-32. Epub 2015 Apr 23.

Siberian Division of the Russian Academy of Medical Sciences, Institute of Regional Pathology and Pathomorphology, Novosibirsk, Russia,

We analyzed ultrastruciture of the cell populations in the prostate gland in chronic nonbacterial prostatitis in a chemical industry worker. It was shown that ultrastructural reorganization of the epithelium consisted in reduction of the secretory compartment of the cytoplasm and dystrophic-degenerative changes in cell organelles. Endothelial cells of the capillaries showed signs of significant degeneration and low intensity of micropinocytosis. Read More

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http://dx.doi.org/10.1007/s10517-015-2872-2DOI Listing
April 2015
1 Read

[Roles of substance P and transient receptor potential vanilloid 1 in neuralgia in rats with chronic nonbacterial prostatitis].

Zhonghua Nan Ke Xue 2015 Feb;21(2):107-12

Objective: To study the possible mechanisms of chronic nonbacterial prostatitis (CNP) pain.

Methods: CNP models were established in male Wistar rats by the autoimmune method. Then the paw withdrawal threshold (PWT) was detected using the Von Frey filament, prostate pathological examination was conducted, the expressions of substance P (SP) and transient receptor potential vanilloid 1 (TRPV1) in the prostate tissue and L5-S2 spinal segments were determined by immunohistochemistry and their correlations were analyzed. Read More

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February 2015
3 Reads

Berberine ameliorates nonbacterial prostatitis via multi-target metabolic network regulation.

OMICS 2015 Mar 14;19(3):186-95. Epub 2015 Jan 14.

National TCM Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine , Harbin, China .

Metabolomics has been increasingly applied to discovering biomarkers and identifying perturbed pathways. Berberine has been shown to exhibit anti-inflammatory, antioxidant, and anticancer properties, but its mechanisms for treating nonbacterial prostatitis (NBP) remain unclear completely. We developed the untargeted metabolomics approach based on UPLC-Q-TOF-HDMS to profile the metabolite changes in urine samples in order to discover novel potential biomarkers to clarify mechanisms of berberine in treating a rat model of capsaicin-induced nonbacterial prostatitis (NBP). Read More

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http://dx.doi.org/10.1089/omi.2014.0112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356222PMC
March 2015
4 Reads
2.362 Impact Factor

[Influence of Kudou Shencha decotion on INF-gamma, ICAM-1, MCP-1 levels of prostate tissue homogenate in immunity prostatitis model rats].

Zhongguo Zhong Yao Za Zhi 2014 May;39(10):1918-20

Objective: To investigate the influence of Kudou Shencha decotion on INF-y, ICAM-1, MCP-1 levels of prostate tissue homogenate in immunity prostatitis model rats.

Method: Forty Wistar male rats were divided into 5 groups randomly: Kudou Shencha decotion group with high dosage and low dosage, Qianleitai group, the model control group and normal group. The rat model of chronic nonbacterial prostatitis was established by multiple hypodermical injection of the suspension of prostatic protein purification with Freund's completed adjuvant. Read More

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May 2014
20 Reads

Chronic pelvic pain syndrome: a clinical enigma.

Postgrad Med 2014 Jul;126(4):115-23

Department of Urology, Carmel Medical Centre, Haifa, Israel.

Chronic nonbacterial prostatitis is an ill-defined, painful clinical condition that is characterized by various nonspecific symptoms, some of which are related to urination or the male reproductive organs. Urologists diagnose this particular condition when the symptoms are not associated with urinary bacterial growth before and after transrectal prostate massage. In this review, we describe the recommended and optional tests that can be performed in these cases. Read More

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http://dx.doi.org/10.3810/pgm.2014.07.2789DOI Listing
July 2014
4 Reads

Increased chromogranin A and neuron-specific enolase in rats with chronic nonbacterial prostatitis induced by 17-beta estradiol combined with castration.

Int J Clin Exp Pathol 2014 15;7(7):3992-9. Epub 2014 Jun 15.

Department of Urology and Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University Hefei 230022, Anhui, China.

Although chronic nonbacterial prostatitis (CNBP) is a common diagnosis in middle-aged men, the etiology of this disease remains poorly understood. Neuroendocrine cells play an important role in the neuroendocrine regulation of the prostate, and chromogranin A (CgA) and neuron-specific enolase (NSE) are regarded as classic markers of neuroendocrine cells. This study aimed to determine CgA and NSE levels in a CNBP rat model to evaluate the role of neuroendocrine cells in the pathogenesis of CNBP. Read More

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http://www.ijcep.com/files/ijcep0000620.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129011PMC
May 2015
7 Reads

Correlation study of chronic nonbacterial prostatitis with the levels of COX-2 and PGE2 in prostatic secretion.

Int Urol Nephrol 2014 Oct 8;46(10):1871-5. Epub 2014 Jun 8.

Department of Urology, Dongying People's Hospital, No. 317, South First Road, Dongying District, Dongying, 257091, Shandong, China.

Objective: The prostatitis syndrome is a multifactorial condition of largely unknown etiology. This study is to analyze the relationship between cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) with the chronic nonbacterial prostatitis (CNBP).

Methods: A total of 172 CNBP patients and 151 healthy males were recruited as CNBP and control group, respectively. Read More

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http://dx.doi.org/10.1007/s11255-014-0743-9DOI Listing
October 2014
11 Reads

Development and validation of an animal model of prostate inflammation-induced chronic pelvic pain: evaluating from inflammation of the prostate to pain behavioral modifications.

PLoS One 2014 13;9(5):e96824. Epub 2014 May 13.

Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is the most common type of prostatitis. Due to the lack of a suitable animal model partly, the pathogenesis for this condition is obscure. In the current study we developed and validated an animal model for nonbacterial prostatitis and prostate inflammation-induced chronic pelvic pain in rats with the use of intraprostatic injection of λ-carrageenan. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096824PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019557PMC
January 2015
2 Reads

The phytotherapeutic agent, eviprostat, suppresses stromal proliferation and inflammation even after establishment of nonbacterial prostatitis in the rat prostate.

Urology 2014 Mar;83(3):528-34

Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan. Electronic address:

Objective: To evaluate the effect of phytotherapeutic agent, Eviprostat, administered after the establishment of nonbacterial prostatitis (NBP) on the stroma-to-epithelium ratio (S/E ratio), inflammatory scores, tissue macrophage infiltration, and cytokines and chemokines levels in prostate tissue and urine.

Materials And Methods: Ten-month-old male Wistar rats were castrated and exposed to 17-beta-isomer of estradiol for 30 days to induce NBP. Twenty-five NBP rats were divided into 5 groups: (1) NBP (0) rats sacrificed immediately after the establishment of NBP; (2,3) NBP (30)/control (CTL) and NBP (30)/Eviprostat (EVI) rats fed without or with 0. Read More

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http://dx.doi.org/10.1016/j.urology.2013.11.033DOI Listing
March 2014
4 Reads