283 results match your criteria Prostatitis Nonbacterial

Targeting CXCL12/CXCR4 Signaling with AMD3100 Might Selectively Suppress CXCR4+ T-Cell Chemotaxis Leading to the Alleviation of Chronic Prostatitis.

J Inflamm Res 2022 21;15:2551-2566. Epub 2022 Apr 21.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People's Republic of China.

Background: Chronic nonbacterial prostatitis (CNP) has a high incidence, low cure rate, and unclear pathogenesis. Here, we aimed to systematically identify effective diagnostic and therapeutic targets for CNP.

Methods: Prostate tissues were obtained from established mouse models and negative controls and were used for mRNA array sequencing and immunohistochemistry (IHC) staining. Read More

View Article and Full-Text PDF

Metabolites of gut microbiota fermenting Poria cocos polysaccharide alleviates chronic nonbacterial prostatitis in rats.

Int J Biol Macromol 2022 Jun 8;209(Pt B):1593-1604. Epub 2022 Apr 8.

Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China. Electronic address:

Chronic nonbacterial prostatitis (CNP) is a common urology disease. Our previous research found Poria cocos polysaccharides (PPs) alleviated CNP and suggested the effect was related to gut bacteria. We investigated the crucial bacteria and their metabolites responsible for the anti-CNP effect to discover possible mechanisms. Read More

View Article and Full-Text PDF

Dihydroartemisinin ameliorates chronic nonbacterial prostatitis and epithelial cellular inflammation by blocking the E2F7/HIF1α pathway.

Inflamm Res 2022 Apr 13;71(4):449-460. Epub 2022 Mar 13.

Department of Urology, Hebei Province of Chinese Medicine/Affiliated Hospital of Hebei University of Chinese Medicine, No. 389, Zhongshan East Road, Shijiazhuang, 050000, Hebei Province, People's Republic of China.

Objective: Chronic nonbacterial prostatitis (CNP) has remained one of the most prevalent urological diseases, particularly in older men. Dihydroartemisinin (DHA) has been identified as a semi-synthetic derivative of artemisinin that exhibits broad protective effects. However, the role of DHA in inhibiting CNP inflammation and prostatic epithelial cell proliferation remains largely unknown. Read More

View Article and Full-Text PDF

The Translational Role of Animal Models for Estrogen-Related Functional Bladder Outlet Obstruction and Prostatic Inflammation.

Vet Sci 2022 Jan 31;9(2). Epub 2022 Jan 31.

Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland.

The prevalence of LUTS and prostatic diseases increases with age both in humans and companion animals, suggesting that a common underlying cause of these conditions may be age-associated alterations in the balance of sex hormones. The symptoms are present with different and variable micturition dysfunctions and can be assigned to different clinical conditions including bladder outlet obstruction (BOO). LUTS may also be linked to chronic non-bacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS), but the relationship between these conditions is unknown. Read More

View Article and Full-Text PDF
January 2022

[Jiedu Huoxue Decoction improves mitochondrial damage of the prostate in rats with chronic nonbacterial prostatitis].

Zhonghua Nan Ke Xue 2021 Jun;27(6):483-488

Department of Andrology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330006, China.

Objective: To explore the possible pathogenesis of chronic nonbacterial prostatitis (CNP) in rats from the perspective of mitochondria, and the interventional effect of Jiedu Huoxue Decoction (JHD) on CNP.

Methods: Forty clean-grade SD male rats were randomly divided into 4 groups of an equal number, sham control, CNP model control, Qianliekang Tablets intervention (QLK) and JHD intervention, those in the former two groups treated intragastrically with normal saline, and those in the latter two with QLK and JHD, respectively, at 2g/kg qd for 30 successive days. Then serum and prostate tissue samples were collected from the rats for calculation of the organ coefficients, HE staining, extraction of mitochondria in the prostate tissue, measurement of the levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-PX) and Na+-K+-ATPase by colorimetric assay, and observation of the ultrastructural changes of the prostatic epithelial cells under the transmission electron microscope (TEM). Read More

View Article and Full-Text PDF

Screening of anti-chronic nonbacterial prostatitis activity of different extractions of the aerial part of , and network pharmacology research.

Biomed Rep 2021 Dec 29;15(6):99. Epub 2021 Sep 29.

Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Medicinal Plant Development, Beijing 100193, P.R. China.

In the present study, anti-chronic nonbacterial prostatitis (CNP) pharmacological experiments using water and ethanol extraction of the aerial parts of were performed to select the best active parts by comparing their efficacy in a CNP model established by injecting carrageenin into the ventral lobe of rat prostate. The anti-CNP activities and expression of serum inflammatory factors in rats were also analyzed. A Protein-Protein Interaction network was constructed, and core targets were screened using topology and analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Read More

View Article and Full-Text PDF
December 2021

Ipertrofan Revisited-The Proposal of the Complete Stereochemistry of Mepartricin A and B.

Molecules 2021 Sep 12;26(18). Epub 2021 Sep 12.

Department of Pharmaceutical Technology and Biochemistry and BioTechMed Centre, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233 Gdańsk, Poland.

Being a methyl ester of partricin, the mepartricin complex is the active substance of a drug called Ipertrofan (Tricandil), which was proven to be useful in treatment of benign prostatic hyperplasia and chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Nevertheless, no direct structural evidence on the stereochemistry of its components has been presented to date. In this contribution, we have conducted detailed, NMR-driven stereochemical studies on mepartricins A and B, aided by molecular dynamics simulations. Read More

View Article and Full-Text PDF
September 2021

Effects of Xialiqi capsules on rats with nonbacterial prostatitis.

Am J Transl Res 2021 15;13(8):9241-9247. Epub 2021 Aug 15.

Department of Urology, Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai, China.

Objective: To investigate the feasibility and effectiveness of Xialiqi capsules in rats with nonbacterial prostatitis.

Methods: A total of 90 healthy male SD rats, weighing 200-220 g, were randomly divided into a blank control group (BCG, n=30), a model group (MG, n=30), and an intervention group (IG, n=30). After establishing the model of chronic nonbacterial prostatitis, IG was treated with 50 mg/kg Xialiqi capsules via gavage. Read More

View Article and Full-Text PDF

Effects of Electroacupuncture on Alleviating Prostatodynia and Inflammation in Rats with Chronic Nonbacterial Prostatitis.

Chao Zhang Ding Li

J Pain Res 2021 7;14:2757-2765. Epub 2021 Sep 7.

School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

Purpose: Chronic prostatitis (CP) is a common urinary disease characterized by a complex sequence of symptoms including prostatodynia, which results in significant physical pain and mental burden to affected patients. Currently, CP has no standard treatment. Thus, physical therapy electroacupuncture (EA) which has been successful in treating several inflammation-related pain conditions was used to determine its effect on rats with CP. Read More

View Article and Full-Text PDF
September 2021

EDCs and male urogenital cancers.

Adv Pharmacol 2021 24;92:521-553. Epub 2021 Jun 24.

Environmental Chemical Pollution and Health Research Unit, Faculty of Health Sciences, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa; Environmental Chemical Pollution and Health Research Unit, Faculty of Health Sciences, School of Medicine, Department of Urology, University of Pretoria, Pretoria, South Africa.

Male sex determination and sexual differentiation occur between 6-12 weeks of gestation. During the "male programming window" the fetal testes start to produce testosterone that initiates the development of the male reproductive tract. Exposure to endocrine disrupting chemicals (EDCs) able to mimic or disrupt steroid hormone actions may disrupt testicular development and adversely impact reproductive health at birth, during puberty and adulthood. Read More

View Article and Full-Text PDF
November 2021

Poria cocos polysaccharides attenuate chronic nonbacterial prostatitis by targeting the gut microbiota: Comparative study of Poria cocos polysaccharides and finasteride in treating chronic prostatitis.

Int J Biol Macromol 2021 Oct 21;189:346-355. Epub 2021 Aug 21.

Department of Food Science and Engineering, Jinan University, Guangzhou, Guangdong 510632, PR China. Electronic address:

Finasteride is an antiandrogenic drug used for the clinical treatment of chronic nonbacterial prostatitis (CNP). Recently, we reported the anti-CNP activity of Poria cocos polysaccharides (PPs) in a rat model. In this study, we compared the differences between PPs and finasteride in treating CNP, especially their effects on the gut microbiota. Read More

View Article and Full-Text PDF
October 2021

Identification of Altered Proteins in the Plasma of Rats With Chronic Prostatic Inflammation Induced by Estradiol Benzoate and Sex Hormones.

ACS Omega 2021 Jun 21;6(22):14361-14370. Epub 2021 May 21.

Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, United States.

The cause of nonbacterial chronic prostatitis is unknown, yet its prevalence accounts for more than 90% of all prostatitis cases. Whole blood, plasma, and serum have been used to identify prostate cancer biomarkers; however, few studies have performed protein profiling to identify prostatitis biomarkers. The purpose of this study was to identify protein biomarkers altered by chronic prostatitis. Read More

View Article and Full-Text PDF

Comparing two different low-intensity shockwave therapy frequency protocols for nonbacterial chronic prostatitis/chronic pelvic pain syndrome: A two-arm, parallel-group randomized controlled trial.

Prostate 2021 06 30;81(9):499-507. Epub 2021 Apr 30.

Department of Urology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Despite encouraging results, the optimal low-intensity shockwave therapy (LiST) protocol in patients with chronic prostatitis/chronic pelvic pain syndrome (CPPS) remains unknown. We conducted a two-arm, parallel-group, randomized controlled trial aiming to compare the efficacy and safety of six LiST sessions applied once or twice weekly.

Methods: Fifty patients with CP/CPPS type IIIb were randomly assigned to six LiST sessions once (Group A, n = 25) or twice weekly (Group B, n = 25). Read More

View Article and Full-Text PDF

Extracellular vesicles released from hiPSC-derived MSCs attenuate chronic prostatitis/chronic pelvic pain syndrome in rats by immunoregulation.

Stem Cell Res Ther 2021 03 20;12(1):198. Epub 2021 Mar 20.

Department of Urology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable nonbacterial inflammatory disease. Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs, iMSCs) have been well documented for the management of inflammatory and autoimmune disorders because of their powerful immunoregulatory and anti-inflammatory capacities. Recently, studies have indicated that extracellular vesicles (EVs) released from iMSCs hold biological functions similar to their parental cells. Read More

View Article and Full-Text PDF

Tadalafil Alleviates LPS-Induced Inflammation and Oxidative Stress of RWPE-1 Cell by Regulating the Akt/Nrf2 Signaling Pathway.

Inflammation 2021 Jun 5;44(3):890-898. Epub 2021 Jan 5.

Center for Reproductive Medicine, The 904th Hospital of Joint Logistic Support Force, PLA, 101 Xingyuan North Road, Wuxi, 214043, Jiangsu, China.

Tadalafil (TAD) is primarily a treatment drug for erectile dysfunction. Studies have shown that TAD has a therapeutic effect on prostatitis, but the specific mechanism has not been reported. LPS induced RWPE-1 cells to form a model of chronic nonbacterial prostatitis (CNP). Read More

View Article and Full-Text PDF

Polysaccharides Alleviates Chronic Nonbacterial Prostatitis by Preventing Oxidative Stress, Regulating Hormone Production, Modifying Gut Microbiota, and Remodeling the DNA Methylome.

J Agric Food Chem 2020 Nov 29;68(45):12661-12670. Epub 2020 Oct 29.

Department of Food Science and Engineering, Jinan University, Guangzhou, Guangdong 510632, P. R. China.

Chronic nonbacterial prostatitis (CNP) is a common male disease with high incidence and low cure rate. This study aims to investigate the anti-CNP potential of polysaccharides (PPs) in a λ-carrageenan-induced CNP rat model. Results showed that PPs exerted anti-CNP functions by reducing the prostate weight and prostate index as well as the level of C-reactive protein (CRP) and pro-inflammatory cytokines (TNF-α and IL-1β). Read More

View Article and Full-Text PDF
November 2020

[Increased Notch receptors induces CD8(+) T cell exhaustion in patients with prostate cancer].

Zhonghua Yi Xue Za Zhi 2020 Sep;100(34):2669-2674

Department of Clinical Laboratory, Shanxi Provincial People's Hospital, Taiyuan 030012, China.

To investigate Notch receptor expression in CD8(+) T cells in patients with prostate cancer, and to assess the influence of Notch signaling pathway on the function of CD8(+)T cells inpatients with prostate cancer. Forty-five patients with prostate cancer, forty-one patients with nonbacterial prostatitis, and thirty healthy controls who were hospitalized or followed-up in Shanxi Provincial People's Hospital between November 2017 and June 2018 were enrolled. CD8(+)T cells were purified, and mRNA relative levels of Notch1-4 were semi-quantified by reverse transcriptional real-time PCR. Read More

View Article and Full-Text PDF
September 2020

The effect of Jiedu Huoxue decoction on rat model of experimental nonbacterial prostatitis via regulation of miRNAs.

Pharm Biol 2020 Dec;58(1):745-759

Department of TCM Surgery, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, P.R. China.

Context: The underlying mechanisms of Jiedu Huoxue decoction (JDHXD) in treating chronic prostatitis have not been fully explored.

Objective: This study investigates the miRNAs as potential biomarkers and the effect of JDHXD on the rat model of experimental nonbacterial prostatitis.

Materials And Methods: Fifty-four Sprague-Dawley male rats were randomly divided into normal control, model, JDHXD low dose (0. Read More

View Article and Full-Text PDF
December 2020

Management of Chronic Nonbacterial Prostatitis and Chronic Pelvic Pain Syndrome in the Adult Male Patient with Comorbid Conditions.

J Christ Nurs 2020 Jul/Sep;37(3):E21-E26

Faith community nurses often counsel patients regarding illness management and are in a unique position to provide support to those facing multiple illnesses. When faced with multiple illnesses, men with urologic problems commonly do not mention them at routine exams, yet older patients might ask a trusted faith community nurse about urological concerns such as prostatitis. The National Institutes of Health developed a new classification structure for prostatitis in the 1990s, combining two types of prostate conditions into a new category. Read More

View Article and Full-Text PDF
November 2021

Effectiveness and Safety of Umbilicus Treatment with Modified Dinggui Powder () in Patients with Chronic Nonbacterial Prostatitis: A Randomized, Double-blind, Placebo-controlled Clinical Trial.

Chin J Integr Med 2021 Mar 1;27(3):170-176. Epub 2020 Apr 1.

School of Acupuncture-Moxbustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Objective: To evaluate the effectiveness and safety of Chinese herbal external umbilicus treatment with Modified Dinggui Powder (, MDGP) in patients with chronic nonbacterial prostatitis (CNP).

Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted among 72 patients with CNP. Participants were randomly allocated to a treatment group and a placebo group using computer software in a 1:1 ratio, and received either MDGP external umbilicus treatment (MDGP group, 36 cases) or placebo control groupl (36 cases) at acupoints Shenque (CV 8), twice a week for 4 weeks. Read More

View Article and Full-Text PDF

Expression and Regulation of Brain Natriuretic Peptide and Natriuretic Peptide Receptor A (NPR-A) in L6-S1 Dorsal Root Ganglia in a Rat Model of Chronic Nonbacterial Prostatitis.

Med Sci Monit 2019 Nov 28;25:9042-9047. Epub 2019 Nov 28.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).

BACKGROUND The study aimed to investigate the expression of brain natriuretic peptide (BNP) and natriuretic peptide receptor A (NPR-A) in L6-S1 dorsal root ganglia (DRG) in a rat model of chronic nonbacterial prostatitis (CNP). MATERIAL AND METHODS One hundred specific pathogen-free (SPF) male Sprague-Dawley rats were randomly divided into a control group (N=50) and a study group (N=50). The control group underwent prostatic injection of 0. Read More

View Article and Full-Text PDF
November 2019

A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis.

BMC Urol 2019 Oct 23;19(1):99. Epub 2019 Oct 23.

Department of Urology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Background: Chronic inflammation is thought to be a major causative factor for the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Tadalafil, a phosphodiesterase type 5 inhibitor (PDE5-I), which has been used for the treatment of BPH-LUTS in daily practice, is known to act at several urinary organs. In this study, focused on the prostate, we examined the effect of tadalafil on the pathological changes and inflammatory factors in a rat nonbacterial prostatitis (NBP) model. Read More

View Article and Full-Text PDF
October 2019

Low Energy Shock Wave Therapy Inhibits Inflammatory Molecules and Suppresses Prostatic Pain and Hypersensitivity in a Capsaicin Induced Prostatitis Model in Rats.

Int J Mol Sci 2019 Sep 26;20(19). Epub 2019 Sep 26.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

The effect of low energy shock wave (LESW) therapy on the changes of inflammatory molecules and pain reaction was studied in a capsaicin (10 mM, 0.1 cc) induced prostatitis model in rats. Intraprostatic capsaicin injection induced a pain reaction, including closing of the eyes, hypolocomotion, and tactile allodynia, which effects were ameliorated by LESW treatment. Read More

View Article and Full-Text PDF
September 2019

Herbal Phytotherapy in Chronic Nonbacterial Prostatitis.

World J Mens Health 2019 Sep 3. Epub 2019 Sep 3.

The Korea Institute for Public Sperm Bank, Busan, Korea.

View Article and Full-Text PDF
September 2019

[Clinical treatment of chronic nonbacterial prostatitis of kidney- deficiency type by acupuncture of Sanhuang points].

Zhen Ci Yan Jiu 2019 Jun;44(6):443-5

Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006.

Objective: To observe the clinical effect of acupuncture stimulation of Sanhuang points in the treatment of chronic nonbacterial prostatitis (CNP) of kidney- deficiency type.

Methods: A total of 60 CNP outpatients were equally randomized into medication(control) group and acupuncture plus medication (acupuncture) group. Patients of the control group were ordered to take Tamsulosin (0. Read More

View Article and Full-Text PDF

Mechanism Investigation of L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology.

Molecules 2019 Jun 18;24(12). Epub 2019 Jun 18.

Dalian Wuzhou Holy Herb Scientific and Techonological Co. Ltd, Dalian 116600, China.

The major objective of this study was to investigate the anti-chronic nonbacterial prostatitis (CNP) mechanism of by metabolomics and network pharmacology. The study demonstrated that the flavonoids and polysaccharides of could alleviate prostatitis by improving the level of DHT, reducing the secretion of PSA and TNF-α. Besides, both could enhance Na/K-ATPase activity, decrease the O consumption, CO production, heat production, energy expenditure of rats and promote respiratory exchange ratio of rats. Read More

View Article and Full-Text PDF

Characterization a model of prostatic diseases and obstructive voiding induced by sex hormone imbalance in the Wistar and Noble rats.

Transl Androl Urol 2019 Mar;8(Suppl 1):S45-S57

Pharmatest Services Ltd., Turku, Finland.

Background: Chronic nonbacterial prostatitis associated with lower urinary tract symptoms (LUTS) is a prevalent condition in men. One potential pathophysiological factor is change in sex hormone, testosterone and estrogen, balance. Inflammation, cancer and obstructive voiding has been induced in the Noble rat strain by altering levels of sex hormones. Read More

View Article and Full-Text PDF

Chronic prostatitis/chronic pelvic pain syndrome increases susceptibility to seizures in rats and alters brain levels of IL-1β and IL-6.

Epilepsy Res 2019 07 22;153:19-27. Epub 2019 Mar 22.

Laboratory of Neurophysiology, Institute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, Belgrade, Serbia. Electronic address:

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a result of interplay between psychological, immune, neurological and genetic factors, manifested by variety of urological, as well as brain-related symptoms. However, its relation with brain excitability has not been addressed. herefore, our aim was to assess susceptibility to seizures in rats with CP/CPPS. Read More

View Article and Full-Text PDF

Long-lasting bladder overactivity and bladder afferent hyperexcitability in rats with chemically-induced prostatic inflammation.

Prostate 2019 06 22;79(8):872-879. Epub 2019 Mar 22.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Background: Benign prostatic hyperplasia (BPH) is one of the major causes of lower urinary tract symptoms (LUTS), including storage LUTS such as urinary frequency and urgency. Recently, a growing number of clinical studies indicate that prostatic inflammation could be an important pathophysiological mechanism inducing storage LUTS in patients with BPH. Here we aimed to investigate whether nonbacterial prostatic inflammation in a rat model induced by intraprostatic formalin injection can lead to long-lasting bladder overactivity and changes in bladder afferent neuron excitability. Read More

View Article and Full-Text PDF

The role of ethanol in the pathogenesis of non‑bacterial prostatitis.

Mol Med Rep 2019 May 27;19(5):3848-3854. Epub 2019 Feb 27.

Department of Urology, Shanghai Fengxian District Central Hospital, Shanghai 201499, P.R. China.

Chronic prostatitis (CP) is a common disease within the field of urology, and it is difficult to treat. Prostatitis mainly occurs in young men and presents with various clinical symptoms, manifested as urinary frequency, urinary urgency, urinary pain, prolonged urination, dysuria and other urinary abnormalities. There are various forms of the syndrome that can cause discomfort or pain in the perineum, the lower abdomen, the penis, the scrotum and the lumbosacral area. Read More

View Article and Full-Text PDF