272 results match your criteria Prostatitis Nonbacterial


Identification of Altered Proteins in the Plasma of Rats With Chronic Prostatic Inflammation Induced by Estradiol Benzoate and Sex Hormones.

ACS Omega 2021 Jun 21;6(22):14361-14370. Epub 2021 May 21.

Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, United States.

The cause of nonbacterial chronic prostatitis is unknown, yet its prevalence accounts for more than 90% of all prostatitis cases. Whole blood, plasma, and serum have been used to identify prostate cancer biomarkers; however, few studies have performed protein profiling to identify prostatitis biomarkers. The purpose of this study was to identify protein biomarkers altered by chronic prostatitis. Read More

View Article and Full-Text PDF

Comparing two different low-intensity shockwave therapy frequency protocols for nonbacterial chronic prostatitis/chronic pelvic pain syndrome: A two-arm, parallel-group randomized controlled trial.

Prostate 2021 Jun 30;81(9):499-507. Epub 2021 Apr 30.

Department of Urology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Despite encouraging results, the optimal low-intensity shockwave therapy (LiST) protocol in patients with chronic prostatitis/chronic pelvic pain syndrome (CPPS) remains unknown. We conducted a two-arm, parallel-group, randomized controlled trial aiming to compare the efficacy and safety of six LiST sessions applied once or twice weekly.

Methods: Fifty patients with CP/CPPS type IIIb were randomly assigned to six LiST sessions once (Group A, n = 25) or twice weekly (Group B, n = 25). Read More

View Article and Full-Text PDF

Extracellular vesicles released from hiPSC-derived MSCs attenuate chronic prostatitis/chronic pelvic pain syndrome in rats by immunoregulation.

Stem Cell Res Ther 2021 Mar 20;12(1):198. Epub 2021 Mar 20.

Department of Urology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable nonbacterial inflammatory disease. Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs, iMSCs) have been well documented for the management of inflammatory and autoimmune disorders because of their powerful immunoregulatory and anti-inflammatory capacities. Recently, studies have indicated that extracellular vesicles (EVs) released from iMSCs hold biological functions similar to their parental cells. Read More

View Article and Full-Text PDF

Tadalafil Alleviates LPS-Induced Inflammation and Oxidative Stress of RWPE-1 Cell by Regulating the Akt/Nrf2 Signaling Pathway.

Inflammation 2021 Jun 5;44(3):890-898. Epub 2021 Jan 5.

Center for Reproductive Medicine, The 904th Hospital of Joint Logistic Support Force, PLA, 101 Xingyuan North Road, Wuxi, 214043, Jiangsu, China.

Tadalafil (TAD) is primarily a treatment drug for erectile dysfunction. Studies have shown that TAD has a therapeutic effect on prostatitis, but the specific mechanism has not been reported. LPS induced RWPE-1 cells to form a model of chronic nonbacterial prostatitis (CNP). Read More

View Article and Full-Text PDF

Polysaccharides Alleviates Chronic Nonbacterial Prostatitis by Preventing Oxidative Stress, Regulating Hormone Production, Modifying Gut Microbiota, and Remodeling the DNA Methylome.

J Agric Food Chem 2020 Nov 29;68(45):12661-12670. Epub 2020 Oct 29.

Department of Food Science and Engineering, Jinan University, Guangzhou, Guangdong 510632, P. R. China.

Chronic nonbacterial prostatitis (CNP) is a common male disease with high incidence and low cure rate. This study aims to investigate the anti-CNP potential of polysaccharides (PPs) in a λ-carrageenan-induced CNP rat model. Results showed that PPs exerted anti-CNP functions by reducing the prostate weight and prostate index as well as the level of C-reactive protein (CRP) and pro-inflammatory cytokines (TNF-α and IL-1β). Read More

View Article and Full-Text PDF
November 2020

[Increased Notch receptors induces CD8(+) T cell exhaustion in patients with prostate cancer].

Zhonghua Yi Xue Za Zhi 2020 Sep;100(34):2669-2674

Department of Clinical Laboratory, Shanxi Provincial People's Hospital, Taiyuan 030012, China.

To investigate Notch receptor expression in CD8(+) T cells in patients with prostate cancer, and to assess the influence of Notch signaling pathway on the function of CD8(+)T cells inpatients with prostate cancer. Forty-five patients with prostate cancer, forty-one patients with nonbacterial prostatitis, and thirty healthy controls who were hospitalized or followed-up in Shanxi Provincial People's Hospital between November 2017 and June 2018 were enrolled. CD8(+)T cells were purified, and mRNA relative levels of Notch1-4 were semi-quantified by reverse transcriptional real-time PCR. Read More

View Article and Full-Text PDF
September 2020

The effect of Jiedu Huoxue decoction on rat model of experimental nonbacterial prostatitis via regulation of miRNAs.

Pharm Biol 2020 Dec;58(1):745-759

Department of TCM Surgery, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, P.R. China.

Context: The underlying mechanisms of Jiedu Huoxue decoction (JDHXD) in treating chronic prostatitis have not been fully explored.

Objective: This study investigates the miRNAs as potential biomarkers and the effect of JDHXD on the rat model of experimental nonbacterial prostatitis.

Materials And Methods: Fifty-four Sprague-Dawley male rats were randomly divided into normal control, model, JDHXD low dose (0. Read More

View Article and Full-Text PDF
December 2020

Management of Chronic Nonbacterial Prostatitis and Chronic Pelvic Pain Syndrome in the Adult Male Patient with Comorbid Conditions.

J Christ Nurs 2020 Jul/Sep;37(3):E21-E26

Faith community nurses often counsel patients regarding illness management and are in a unique position to provide support to those facing multiple illnesses. When faced with multiple illnesses, men with urologic problems commonly do not mention them at routine exams, yet older patients might ask a trusted faith community nurse about urological concerns such as prostatitis. The National Institutes of Health developed a new classification structure for prostatitis in the 1990s, combining two types of prostate conditions into a new category. Read More

View Article and Full-Text PDF

Effectiveness and Safety of Umbilicus Treatment with Modified Dinggui Powder () in Patients with Chronic Nonbacterial Prostatitis: A Randomized, Double-blind, Placebo-controlled Clinical Trial.

Chin J Integr Med 2021 Mar 1;27(3):170-176. Epub 2020 Apr 1.

School of Acupuncture-Moxbustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Objective: To evaluate the effectiveness and safety of Chinese herbal external umbilicus treatment with Modified Dinggui Powder (, MDGP) in patients with chronic nonbacterial prostatitis (CNP).

Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted among 72 patients with CNP. Participants were randomly allocated to a treatment group and a placebo group using computer software in a 1:1 ratio, and received either MDGP external umbilicus treatment (MDGP group, 36 cases) or placebo control groupl (36 cases) at acupoints Shenque (CV 8), twice a week for 4 weeks. Read More

View Article and Full-Text PDF

Expression and Regulation of Brain Natriuretic Peptide and Natriuretic Peptide Receptor A (NPR-A) in L6-S1 Dorsal Root Ganglia in a Rat Model of Chronic Nonbacterial Prostatitis.

Med Sci Monit 2019 Nov 28;25:9042-9047. Epub 2019 Nov 28.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).

BACKGROUND The study aimed to investigate the expression of brain natriuretic peptide (BNP) and natriuretic peptide receptor A (NPR-A) in L6-S1 dorsal root ganglia (DRG) in a rat model of chronic nonbacterial prostatitis (CNP). MATERIAL AND METHODS One hundred specific pathogen-free (SPF) male Sprague-Dawley rats were randomly divided into a control group (N=50) and a study group (N=50). The control group underwent prostatic injection of 0. Read More

View Article and Full-Text PDF
November 2019

A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis.

BMC Urol 2019 Oct 23;19(1):99. Epub 2019 Oct 23.

Department of Urology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Background: Chronic inflammation is thought to be a major causative factor for the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Tadalafil, a phosphodiesterase type 5 inhibitor (PDE5-I), which has been used for the treatment of BPH-LUTS in daily practice, is known to act at several urinary organs. In this study, focused on the prostate, we examined the effect of tadalafil on the pathological changes and inflammatory factors in a rat nonbacterial prostatitis (NBP) model. Read More

View Article and Full-Text PDF
October 2019

Low Energy Shock Wave Therapy Inhibits Inflammatory Molecules and Suppresses Prostatic Pain and Hypersensitivity in a Capsaicin Induced Prostatitis Model in Rats.

Int J Mol Sci 2019 Sep 26;20(19). Epub 2019 Sep 26.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

The effect of low energy shock wave (LESW) therapy on the changes of inflammatory molecules and pain reaction was studied in a capsaicin (10 mM, 0.1 cc) induced prostatitis model in rats. Intraprostatic capsaicin injection induced a pain reaction, including closing of the eyes, hypolocomotion, and tactile allodynia, which effects were ameliorated by LESW treatment. Read More

View Article and Full-Text PDF
September 2019

Herbal Phytotherapy in Chronic Nonbacterial Prostatitis.

World J Mens Health 2019 Sep 3. Epub 2019 Sep 3.

The Korea Institute for Public Sperm Bank, Busan, Korea.

View Article and Full-Text PDF
September 2019

[Clinical treatment of chronic nonbacterial prostatitis of kidney- deficiency type by acupuncture of Sanhuang points].

Zhen Ci Yan Jiu 2019 Jun;44(6):443-5

Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006.

Objective: To observe the clinical effect of acupuncture stimulation of Sanhuang points in the treatment of chronic nonbacterial prostatitis (CNP) of kidney- deficiency type.

Methods: A total of 60 CNP outpatients were equally randomized into medication(control) group and acupuncture plus medication (acupuncture) group. Patients of the control group were ordered to take Tamsulosin (0. Read More

View Article and Full-Text PDF

Mechanism Investigation of L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology.

Molecules 2019 Jun 18;24(12). Epub 2019 Jun 18.

Dalian Wuzhou Holy Herb Scientific and Techonological Co. Ltd, Dalian 116600, China.

The major objective of this study was to investigate the anti-chronic nonbacterial prostatitis (CNP) mechanism of by metabolomics and network pharmacology. The study demonstrated that the flavonoids and polysaccharides of could alleviate prostatitis by improving the level of DHT, reducing the secretion of PSA and TNF-α. Besides, both could enhance Na/K-ATPase activity, decrease the O consumption, CO production, heat production, energy expenditure of rats and promote respiratory exchange ratio of rats. Read More

View Article and Full-Text PDF

Characterization a model of prostatic diseases and obstructive voiding induced by sex hormone imbalance in the Wistar and Noble rats.

Transl Androl Urol 2019 Mar;8(Suppl 1):S45-S57

Pharmatest Services Ltd., Turku, Finland.

Background: Chronic nonbacterial prostatitis associated with lower urinary tract symptoms (LUTS) is a prevalent condition in men. One potential pathophysiological factor is change in sex hormone, testosterone and estrogen, balance. Inflammation, cancer and obstructive voiding has been induced in the Noble rat strain by altering levels of sex hormones. Read More

View Article and Full-Text PDF

Chronic prostatitis/chronic pelvic pain syndrome increases susceptibility to seizures in rats and alters brain levels of IL-1β and IL-6.

Epilepsy Res 2019 07 22;153:19-27. Epub 2019 Mar 22.

Laboratory of Neurophysiology, Institute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, Belgrade, Serbia. Electronic address:

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a result of interplay between psychological, immune, neurological and genetic factors, manifested by variety of urological, as well as brain-related symptoms. However, its relation with brain excitability has not been addressed. herefore, our aim was to assess susceptibility to seizures in rats with CP/CPPS. Read More

View Article and Full-Text PDF

Long-lasting bladder overactivity and bladder afferent hyperexcitability in rats with chemically-induced prostatic inflammation.

Prostate 2019 06 22;79(8):872-879. Epub 2019 Mar 22.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Background: Benign prostatic hyperplasia (BPH) is one of the major causes of lower urinary tract symptoms (LUTS), including storage LUTS such as urinary frequency and urgency. Recently, a growing number of clinical studies indicate that prostatic inflammation could be an important pathophysiological mechanism inducing storage LUTS in patients with BPH. Here we aimed to investigate whether nonbacterial prostatic inflammation in a rat model induced by intraprostatic formalin injection can lead to long-lasting bladder overactivity and changes in bladder afferent neuron excitability. Read More

View Article and Full-Text PDF

The role of ethanol in the pathogenesis of non‑bacterial prostatitis.

Mol Med Rep 2019 May 27;19(5):3848-3854. Epub 2019 Feb 27.

Department of Urology, Shanghai Fengxian District Central Hospital, Shanghai 201499, P.R. China.

Chronic prostatitis (CP) is a common disease within the field of urology, and it is difficult to treat. Prostatitis mainly occurs in young men and presents with various clinical symptoms, manifested as urinary frequency, urinary urgency, urinary pain, prolonged urination, dysuria and other urinary abnormalities. There are various forms of the syndrome that can cause discomfort or pain in the perineum, the lower abdomen, the penis, the scrotum and the lumbosacral area. Read More

View Article and Full-Text PDF

New therapy with XLQ to suppress chronic prostatitis through its anti-inflammatory and antioxidative activities.

J Cell Physiol 2019 08 20;234(10):17570-17577. Epub 2019 Feb 20.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.

Chronic prostatitis is a common urological disease. The etiology of this disease and effective therapy for its treatment are yet to be elucidated. We investigated the functions of XLQ in chronic nonbacterial prostatitis using a complete Freund's adjuvant-induced rat model. Read More

View Article and Full-Text PDF

Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis.

J Pharmacol Sci 2019 Mar 2;139(3):201-208. Epub 2019 Feb 2.

Department of Pharmacy, School of Life and Health Science, Anhui Science and Technology University, Fengyang, Anhui, People's Republic of China. Electronic address:

Objectives: The therapeutic potentiality of Bazhengsan on the chronic nonbacterial prostatitis was investigated.

Methods: Prostatitis was induced by subcutaneous injection of the 17-beta-estradiol (E) and dihydrotestosterone in male rat, and treated with Bazhengsan. After 8 weeks, prostatic fluid was collected for counting lecithin corpuscle density (LCD) and the organs were removed from animals and used for measuring prostate viscera coefficient (PVC). Read More

View Article and Full-Text PDF

[Rationale of use and effectiveness of Longidaza in patients with chronic prostatitis].

Urologiia 2018 Oct(4):64-71

Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia, Novosibirsk, Russia.

Introduction: Chronic inflammation of the prostate leads to the formation of excess fibrous connective tissue, which hinders patients recovery and aggravates the symptoms.

Aim: This study aimed to confirm the correlation between inflammation and prostatic fibrosis and the abnormalities of urodynamic and microcirculation in the prostate gland in humans, and the possibility of increasing the effectiveness of treatment of patients with chronic nonbacterial prostatitis using antisclerotic therapy.

Material And Methods: The study was carried out in two stages. Read More

View Article and Full-Text PDF
October 2018

The Effects of Korea Red Ginseng on Inflammatory Cytokines and Apoptosis in Rat Model with Chronic Nonbacterial Prostatitis.

Biomed Res Int 2019 14;2019:2462561. Epub 2019 Jan 14.

Department of Biomedical Laboratory Science, Catholic Kwandong University, Gangneung, Republic of Korea.

Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. Read More

View Article and Full-Text PDF

[Immediate and long-term effectiveness of combined application of magnetolaser therapy and red light in complex treatment of patients with chronic nonbacterial prostatitis].

Urologiia 2018 Dec(6):101-106

Department of Polyclinic Therapy and Medical Rehabilitation with the course of Additional Professional Education Federal State Educational Institution of Higher Education Altai State Medical University of the Ministry of Health of the Russian Federation, Barnaul, Russia.

The aim of the study was to increase the efficiency of complex treatment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with the combined effect of magnetolaser therapy (MLT) and red light.

Materials And Methods: We examined and included in the study 120 men with a verified diagnosis of CP/CPPS (III B), at the stage of exacerbation. By envelope method, patients were divided into two randomized groups. Read More

View Article and Full-Text PDF
December 2018

MicroRNA expression profile in chronic nonbacterial prostatitis revealed by next-generation small RNA sequencing.

Asian J Androl 2019 Jul-Aug;21(4):351-359

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

MicroRNAs (miRNAs) are considered to be involved in the pathogenic initiation and progression of chronic nonbacterial prostatitis (CNP); however, the comprehensive expression profile of dysregulated miRNAs, relevant signaling pathways, and core machineries in CNP have not been fully elucidated. In the current research, CNP rat models were established through the intraprostatic injection of carrageenan into the prostate. Then, next-generation sequencing was performed to explore the miRNA expression profile in CNP. Read More

View Article and Full-Text PDF

Implications of prostate inflammation on male fertility.

Andrologia 2018 Dec;50(11):e13093

Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.

The prostate is the seat of three major causes of morbidity: benign prostatic hyperplasia, prostate cancer and prostatitis, three conditions in which inflammation has been implicated. A state of inflammation of the prostate gland, originally incited by an infection, an autoimmune response, a neurogenic stimulus or another trigger may have consequences on prostate functionality. In fact, male fertility depends intrinsically on the content of prostatic fluid factors secreted by the prostatic epithelium. Read More

View Article and Full-Text PDF
December 2018

Voiding behavior and chronic pelvic pain in two types of rat nonbacterial prostatitis models: Attenuation of chronic pelvic pain by repeated administration of tadalafil.

Prostate 2019 04 14;79(5):446-453. Epub 2018 Dec 14.

Research Laboratories, Nippon Shinyaku Co., Ltd., Minami-ku, Kyoto, Japan.

Background: Experimental autoimmune prostatitis (EAP) and prostatitis induced by 17β-estradiol treatment combined with castration (hormone/castration-induced prostatitis; HCP) are the most commonly used rodent models of nonbacterial prostatitis. We studied the effect of the phosphodiesterase 5 inhibitor tadalafil on chronic pelvic pain in two such models in rats.

Methods: EAP was induced by intradermal injection of rat prostate antigen and complete Freund's adjuvant on Days 0 and 28. Read More

View Article and Full-Text PDF

Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome‑mediated inflammation.

Mol Med Rep 2019 Jan 21;19(1):221-230. Epub 2018 Nov 21.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Chronic non‑bacterial prostatitis (CNBP) is a common urinary disease and no standard treatments are available at present. Although autophagy serves an important role in a variety of chronic diseases, its role in CNBP is yet to be fully elucidated. Therefore, the present study aimed to investigate the effects of rapamycin‑induced autophagy on CNBP by establishing a rat model. Read More

View Article and Full-Text PDF
January 2019

Trans-perineal pumpkin seed oil phonophoresis as an adjunctive treatment for chronic nonbacterial prostatitis.

Res Rep Urol 2018 18;10:95-101. Epub 2018 Sep 18.

Physiotherapy Department, College of Medical and Health Sciences, Ahlia University, Manama, Kingdom of Bahrain,

Background: A significant number of men who are younger than 50 years visit urologists for interminable prostatitis. This study aimed to thoroughly investigate the effect of pumpkin seed oil (PSO) phonophoresis on chronic nonbacterial prostatitis (CNBP).

Subjects And Methods: Sixty patients with CNBP were randomly assigned to three groups: Group A, wherein patients were treated with PSO using phonophoresis; Group B, where patients underwent transperineal continuous low-intensity ultrasound (LIUS); and Group C, wherein patients underwent placebo LIUS. Read More

View Article and Full-Text PDF
September 2018

Chronic pelvic pain and prostate inflammation in rat experimental autoimmune prostatitis: Effect of a single treatment with phosphodiesterase 5 inhibitors on chronic pelvic pain.

Prostate 2018 11 15;78(15):1157-1165. Epub 2018 Jul 15.

Research Laboratories, Nippon Shinyaku Co., Ltd., Minami-ku, Kyoto, Japan.

Background: Experimental autoimmune prostatitis (EAP) is most often used as a nonbacterial model of chronic prostatitis/chronic pelvic pain. We investigated the development of chronic pelvic pain and inflammatory changes in rat EAP and examined the effect of a single treatment with phosphodiesterase 5 (PDE5) inhibitors on the chronic pelvic pain.

Methods: EAP was induced in rats by intradermal injection of rat prostate antigen and complete Freund's adjuvant on days 0 and 28. Read More

View Article and Full-Text PDF
November 2018