1,845 results match your criteria Prostatitis Bacterial


International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats.

Vet J 2019 May 26;247:8-25. Epub 2019 Feb 26.

School of Veterinary Medicine, Department of Medicine & Epidemiology, 2108 Tupper Hall, University of California-Davis, Davis, CA 95616, USA.

Urinary tract disease is a common clinical presentation in dogs and cats, and a common reason for antimicrobial prescription. This document is a revision and expansion on the 2011 Antimicrobial Use Guidelines for Treatment of Urinary Tract Disease in Dogs and Cats, providing recommendations for diagnosis and management of sporadic bacterial cystitis, recurrent bacterial cystitis, pyelonephritis, bacterial prostatitis, and subclinical bacteriuria. Issues pertaining to urinary catheters, medical dissolution of uroliths and prophylaxis for urological procedures are also addressed. Read More

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http://dx.doi.org/10.1016/j.tvjl.2019.02.008DOI Listing
May 2019
1 Read

Qian lie an suppository (prostant) for chronic prostatitis: A systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2019 Apr;98(14):e15072

Office of Science and Technology Administration, Beijing University of Chinese Medicine, Beijing, China.

Background: Chronic prostatitis (CP) is an inflammation of the prostate gland that seriously affects the quality of life of patients. The existing evidence of antibiotics and α-blockers for the treatment of CP is limited.

Objectives: This review evaluated the effectiveness and safety of Qian Lie An Suppository (Prostant) in treating CP. Read More

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http://dx.doi.org/10.1097/MD.0000000000015072DOI Listing

Overexpression of lncRNA GAS5 suppresses prostatic epithelial cell proliferation by regulating COX-2 in chronic non-bacterial prostatitis.

Cell Cycle 2019 Mar 20:1-9. Epub 2019 Mar 20.

a Department of Urology , The First Affiliated Hospital of Soochow University , Suzhou , Jiangsu , China.

Chronic non-bacterial prostatitis (CNP) is a common urologic disease that is linked to the development of prostate cancer. Long non-coding RNA (lncRNA) GAS5 has been identified to mediate cell proliferation in prostate cancer, although its role in CNP is still unclear. Human prostate epithelial cell line RWPE-1 was induced by lipopolysaccharide (LPS) to mimic CNP model in vitro. Read More

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https://www.tandfonline.com/doi/full/10.1080/15384101.2019.1
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http://dx.doi.org/10.1080/15384101.2019.1593644DOI Listing
March 2019
6 Reads

IL-10 Producing B Cells Dampen Protective T Cell Response and Allow Infection of the Male Genital Tract.

Front Immunol 2019 1;10:356. Epub 2019 Mar 1.

Centro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Córdoba, Argentina.

A significant proportion of individuals develop chronic, persistent and recurrent genital tract infections with , which has been attributed to the numerous strategies that the bacterium uses to subvert host immune responses. Animal chlamydia models have demonstrated that protective immune response is mediated by CD4 Th1 cytokine responses. Herein, we demonstrate that early after infecting the male genital tract, triggers the production of IL-10 by splenic and lymph node cells. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405527PMC
March 2019
1 Read

Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines.

BMJ 2019 02 27;364:l440. Epub 2019 Feb 27.

Modelling and Economics Unit, National Infection Service, Public Health England, London NW9 5EQ, UK.

Objective: To evaluate the duration of prescriptions for antibiotic treatment for common infections in English primary care and to compare this with guideline recommendations.

Design: Cross sectional study.

Setting: General practices contributing to The Health Improvement Network database, 2013-15. Read More

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http://dx.doi.org/10.1136/bmj.l440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391655PMC
February 2019
2 Reads

Oral fosfomycin for the treatment of chronic bacterial prostatitis.

J Antimicrob Chemother 2019 Feb 22. Epub 2019 Feb 22.

1st Department of Internal Medicine & Infectious Diseases, Hygeia General Hospital, Athens, Greece.

Background: Chronic bacterial prostatitis (CBP) is a difficult-to-treat infection as only a few antibiotics achieve therapeutic concentrations in the prostate. Data on the efficacy and safety of oral fosfomycin for the treatment of CBP are limited.

Objectives: To analyse the efficacy and safety of fosfomycin in CBP due to MDR pathogens. Read More

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http://dx.doi.org/10.1093/jac/dkz015DOI Listing
February 2019
4 Reads

Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer.

BMC Genomics 2019 Feb 18;20(1):146. Epub 2019 Feb 18.

Vancouver Prostate Centre, Vancouver, Canada.

Background: Prostate cancer (PCa) is the most common malignant neoplasm among men in many countries. Since most precancerous and cancerous tissues show signs of inflammation, chronic bacterial prostatitis has been hypothesized to be a possible etiology. However, establishing a causal relationship between microbial inflammation and PCa requires a comprehensive analysis of the prostate microbiome. Read More

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http://dx.doi.org/10.1186/s12864-019-5457-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379980PMC
February 2019
3 Reads

Chronic prostatitis caused by extended-spectrum β-lactamase-producing managed using oral fosfomycin-A case report.

IDCases 2019 24;15:e00493. Epub 2019 Jan 24.

Faculty of Medicine of the University of Porto, Infectious Diseases department, Centro Hospitalar de São João, Porto, Portugal.

Prostatitis is a clinical condition of difficult management and with limited antimicrobial options, especially in the setting of antimicrobial resistance. Recurrences are frequent and can be severe. Limited reports support the use of fosfomycin for chronic prostatitis by ESBL-producing bacteria. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360601PMC
January 2019
2 Reads

[Bacterial prostatitis: epidemiology and etiology].

Urologiia 2018 Dec(6):144-148

Department of Urology and Human Reproductive Health with the course of Pediatric Urology-andrology of the Advanced Training and Specialist Professional Retraining Faculty FGBOU VO Rostov State Medical University, Russian Federation Ministry Of Healthcare, Rostov-on-Don, Russia.

Prostatitis is considered as heterogeneous group of the diseases attracting broad interest of researchers worldwide. The acute and chronic stages of the process, as particular categories of bacterial prostatitis, remain in the realities of modern practical and scientific urology with lively discussions. Despite a large number of domestic and international publications, consensus on many topical issues of bacterial prostatitis is currently not achieved. Read More

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December 2018
1 Read

[The features of course of chronic abacterial prostatitis with inflammatory compoment in men of the first period of mature age depending on the somatotype. Part 1: the clinical characteristics].

Urologiia 2018 Dec(6):108-114

FGBOU VO Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky of the Ministry of Health of Russia, Krasnoyarsk, Russia.

Aim: to study the course of chronic abacterial prostatitis with the inflammatory component (CAPIC) depending on the somatotype in men of the first period of mature age taking complex treatment with a use of local and systemic ozone therapy.

Materials And Methods: A total of 306 men of asthenic, normostenic and pyknic somatotypes with CAPIC were followed-up. Along with standard therapy, all patients received systemic and local ozone therapy. Read More

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December 2018
6 Reads

Efficacy of combined prophylactic use of levofloxacin and isepamicin for transrectal prostate needle biopsy: A retrospective single-center study.

J Infect Chemother 2019 May 2;25(5):337-340. Epub 2019 Feb 2.

Integrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.

Purpose: To assess the efficacy of a combined regimen of levofloxacin (LVFX) plus isepamicin (ISP) as prophylaxis for transrectal ultrasound-guided needle biopsy of the prostate (TRUSP-Bx).

Materials And Methods: Overall, 562 patients undergoing TRUSP-Bx were included in the present study. All patients were administered a single-dose of oral LVFX (500 mg) in the morning and intravenous ISP (400 mg) 60 min before biopsy. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.004DOI Listing
May 2019
2 Reads

Is bacterial prostatitis a urinary tract infection?

Nat Rev Urol 2019 Apr;16(4):203-204

Department of Immunology, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1038/s41585-019-0150-1DOI Listing
April 2019
1 Read

Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non-pregnant women.

Cochrane Database Syst Rev 2019 Jan 25;1:CD010871. Epub 2019 Jan 25.

Clinical Research Institute, Faculty of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.

Background: The genital infection caused by Chlamydia trachomatis (CT) is a common sexually transmitted infection (STI) globally. The infection is mainly asymptomatic in women, thus it can produce infertility and chronic pelvic pain. In men infection is mainly symptomatic, but can evolve to prostatitis. Read More

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http://dx.doi.org/10.1002/14651858.CD010871.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353232PMC
January 2019
5 Reads

The role of nutraceutical medications in men with non bacterial chronic prostatitis and chronic pelvic pain syndrome: A prospective non blinded study utilizing flower pollen extracts versus bioflavonoids.

Arch Ital Urol Androl 2019 Jan 18;90(4):260-264. Epub 2019 Jan 18.

Department of Gynaecological and Urological Sciences, Sapienza University of Rome.

Introduction: Chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS) represents a challenge for the urologist, since the therapeutic efficacy does not always result in a satisfactory quality of life for the patients. Often the side effects of the medications used (antiinflammatories, antibiotics, alpha blockers) far outweighs the benefits gained with their admission. The choice of nutraceutical medications is preferred for their effectiveness, that has been accepted and proven by the scientific community, and for the low incidence of side effects. Read More

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https://www.pagepressjournals.org/index.php/aiua/article/vie
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http://dx.doi.org/10.4081/aiua.2018.4.260DOI Listing
January 2019
9 Reads

Multidisciplinary approach to prostatitis.

Arch Ital Urol Androl 2019 Jan 18;90(4):227-248. Epub 2019 Jan 18.

ASST Nord Milano.

The modern clinical research on prostatitis started with the work of Stamey and coworkers who developed the basic principles we are still using. They established the segmented culture technique for localizing the infections in the males to the urethra, the bladder, or the prostate and to differentiate the main categories of prostatitis. Such categories with slight modifications are still used according to the NIH classification: acute bacterial prostatitis, chronic bacterial prostatitis, Chronic Pelvic Pain Syndrome (CPPS) and asymptomatic prostatitis. Read More

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https://www.pagepressjournals.org/index.php/aiua/article/vie
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http://dx.doi.org/10.4081/aiua.2018.4.227DOI Listing
January 2019
25 Reads

Induction of Different Apoptosis Pathways by Two Clinical Isolates Strains in Prostatic Epithelial Cells.

Front Physiol 2018 20;9:1855. Epub 2018 Dec 20.

Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania Luigi Vanvitelli, Naples, Italy.

Bacterial prostatitis is believed to be the leading cause of recurrent urinary tract infections (UTIs) in men under 50 years of age and occurs both as an acute febrile disease responsive to antibiotics and as a chronic infection that is often unresponsive to antibiotic treatment. is more commonly associated with UTIs in these abnormalities, especially in patients undergoing catheterisation. This pathogen is able to colonise the host's tissues and to cause disease thanks to the production of many virulence factors such as fimbriae, flagella, immune avoidance, host-damaging factors, and the ability to form crystalline biofilms. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01855
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http://dx.doi.org/10.3389/fphys.2018.01855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306403PMC
December 2018
6 Reads

[Characteristics of acute bacterial prostatitis in elderly patients attended in the Emergency Department].

Rev Esp Geriatr Gerontol 2018 Dec 31. Epub 2018 Dec 31.

Servicio de Urgencias, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.

Objective: To compare the characteristics of acute bacterial prostatitis between patients ≥75 years old with those <75 years old attended in the Emergency Department.

Material And Methods: A descriptive and observational study was conducted with a prospective follow-up including all consecutive patients with acute bacterial prostatitis that were admitted during one year to the Emergency Department of a tertiary-care hospital. Data were collected for demographic variables, comorbidities, clinical and microbiological findings, treatment, outcome, and re-consultation at 30 days follow-up. Read More

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http://dx.doi.org/10.1016/j.regg.2018.11.002DOI Listing
December 2018
2 Reads

Role of oxidative stress, infection and inflammation in male infertility.

Andrologia 2018 Dec;50(11):e13126

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio.

Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, has been linked to sperm damage and male infertility. There are many sources of OS and inflammation including varicocele, tobacco usage, alcohol, obesity/metabolic syndrome, leukocytospermia, sexually transmitted disease (i.e. Read More

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http://doi.wiley.com/10.1111/and.13126
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http://dx.doi.org/10.1111/and.13126DOI Listing
December 2018
33 Reads
1.172 Impact Factor

Correlation of Ultrasonically Determined Bladder Wall Thickness and Prostatic Calcification With the Urinary, Psychosocial Dysfunction, Organ Specific, Infection and Neurological/Systemic Symptoms, and Tenderness Scoring System.

Urology 2019 Feb 4;124:218-222. Epub 2018 Dec 4.

Department of Urology, Hitit University School of Medicine, Corum, Turkey.

Objective: To evaluate ultrasonically determined bladder wall thickness (BWT) and prostatic calcification presence, in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and to correlate the findings with patient characteristics and the urinary, psychosocial dysfunction, organ specific, infection and neurological/systemic symptoms, and tenderness (UPOINT) classification system.

Material And Methods: Between January 2008 and December 2017, data of 1294 patients diagnosed with chronic prostatitis, in a single urology clinic, meeting a number of selective inclusion/exclusion criteria, were retrospectively analyzed. Patients, compliant to fill out all requested questionnaires, between the ages of 21-65 years were included to the study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295183126
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http://dx.doi.org/10.1016/j.urology.2018.11.029DOI Listing
February 2019
15 Reads
2.188 Impact Factor

Comparison of the delta neutrophil index with procalcitonin, erythrocyte sedimentation rate, and C-reactive protein as predictors of sepsis in patients with acute prostatitis.

Prostate Int 2018 Dec 1;6(4):157-161. Epub 2018 Jun 1.

Department of Urology, Yonsei University College of Medicine, Seoul, Korea.

Background: We investigated the usefulness of inflammatory markers including the delta neutrophil index (DNI), erythrocyte sedimentation rate, C-reactive protein, and procalcitonin as early predictors of sepsis in patients with acute prostatitis (AP). In addition, we evaluated the efficacy of intermittent catheterization for the initial management of acute urinary retention (AUR) in patients with AP.

Materials And Methods: All patients who presented to the emergency department and were admitted to the urology department from January 2011 to December 2013 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.prnil.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251943PMC
December 2018
2 Reads

Advances in Prostatic Diagnostics in Dogs: The Role of Canine Prostatic Specific Esterase in the Early Diagnosis of Prostatic Disorders.

Top Companion Anim Med 2018 Dec 8;33(4):105-108. Epub 2018 Sep 8.

Dipartimento di Medicina Veterinaria (DiMeV), Section of Surgery and Obstetrics, University of Bari Aldo Moro, Italy. Electronic address:

In last years, following the increased canine life expectancy and the rising attention pet-owners devote to their animals, several authors have carried on investigations concerning new techniques to early identify canine prostatic disorders that might affect the dog's quality of life. Prostatic disorders often have an asymptomatic onset and their early diagnosis is difficult: hence, they are usually identified at an advanced stage, only. Traditionally, the diagnosis of prostatic disorders is based on noninvasive tools, such as transrectal and abdominal palpation, seminal or prostatic fluid evaluation, and urinalysis and imaging. Read More

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http://dx.doi.org/10.1053/j.tcam.2018.09.002DOI Listing
December 2018
2 Reads

A prostate derived commensal Staphylococcus epidermidis strain prevents and ameliorates induction of chronic prostatitis by UPEC infection.

Sci Rep 2018 Nov 27;8(1):17420. Epub 2018 Nov 27.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, United States.

Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common syndrome with limited therapies and an unknown etiology. Previously, our laboratory has defined a potential role for pathogenic infection in disease onset. Intra-urethral infection with a uropathogenic Escherichia coli strain isolated from a CP/CPPS patient, CP1, induces prostatic inflammation and tactile allodynia in mice. Read More

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http://www.nature.com/articles/s41598-018-35818-1
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http://dx.doi.org/10.1038/s41598-018-35818-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258684PMC
November 2018
16 Reads

Enrichment of semen culture in the diagnosis of bacterial prostatitis.

J Microbiol Methods 2018 Nov 26;154:124-126. Epub 2018 Oct 26.

Department of Clinical Pathology, Virology Unit, "San Giovanni di Dio e Ruggid'Aragona Hospital", Salerno, Italy.

The objective was to investigate the diagnostic accuracy of our microbiological protocol to simplify the evaluation of bacterial prostatitis in the clinical practice. Our findings show the possibility to apply our alternative enrichment semen culture method to detect prostatic bacterial infection with higher sensitivity than the gold standard M&S technique. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01677012183073
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http://dx.doi.org/10.1016/j.mimet.2018.10.016DOI Listing
November 2018
25 Reads

Septic shock secondary to acute bacterial prostatitis in an HIV-positive male: a novel presentation.

Oxf Med Case Reports 2018 Nov 17;2018(11):omy086. Epub 2018 Oct 17.

Teaching Hospital of Michigan State University, Beaumont Hospital, Farmington Hills, MI, USA.

Acute bacterial prostatitis, an acute infection of the prostate gland, results in lower abdominal pain, flank pain, urinary symptoms and the potential for systemic symptoms like fever and shock. With a high mortality rate if left untreated, acute bacterial prostatitis becomes a true urological emergency, which if allowed to progress, may result in bacteremia, severe sepsis/septic shock and death. Diagnosis is mainly clinical with a detailed history and physical and laboratory evaluation to include a urinalysis. Read More

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https://academic.oup.com/omcr/article/doi/10.1093/omcr/omy08
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http://dx.doi.org/10.1093/omcr/omy086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194185PMC
November 2018
16 Reads

Trans-perineal pumpkin seed oil phonophoresis as an adjunctive treatment for chronic nonbacterial prostatitis.

Res Rep Urol 2018 18;10:95-101. Epub 2018 Sep 18.

Physiotherapy Department, College of Medical and Health Sciences, Ahlia University, Manama, Kingdom of Bahrain,

Background: A significant number of men who are younger than 50 years visit urologists for interminable prostatitis. This study aimed to thoroughly investigate the effect of pumpkin seed oil (PSO) phonophoresis on chronic nonbacterial prostatitis (CNBP).

Subjects And Methods: Sixty patients with CNBP were randomly assigned to three groups: Group A, wherein patients were treated with PSO using phonophoresis; Group B, where patients underwent transperineal continuous low-intensity ultrasound (LIUS); and Group C, wherein patients underwent placebo LIUS. Read More

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https://www.dovepress.com/trans-perineal-pumpkin-seed-oil-ph
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http://dx.doi.org/10.2147/RRU.S167896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149936PMC
September 2018
30 Reads

Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy.

Authors:
Gianni Paulis

Res Rep Urol 2018 17;10:75-87. Epub 2018 Sep 17.

Andrology Center, Villa Benedetta Clinic, Rome, Italy,

This article focuses on the role that oxidative stress plays in chronic prostatitis, not only with respect to the known impact on symptoms and fertility but also especially in relation to possible prostate cancer development. Prostatitis is the most common urologic disease in adult males younger than 50 years and the third most common urologic diagnosis in males older than 50 years. If the germ-causing acute prostatitis is not eliminated, the inflammatory process becomes chronic. Read More

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http://dx.doi.org/10.2147/RRU.S170400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149977PMC
September 2018
6 Reads

Role of gram-positive bacteria in chronic pelvic pain syndrome (CPPS).

Prostate 2019 Feb 21;79(2):160-167. Epub 2018 Sep 21.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Introduction: Chronic pelvic pain syndrome (CPPS) is a complex disorder that affects a large proportion of all men. A limited understanding of its etiology and pathogenesis is reflected by the absence of effective therapies. Although CPPS is deemed clinically non-infectious with no well-defined etiological role for microbes, bacteria is readily isolated from both healthy and patient prostate secretion and urine samples. Read More

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http://doi.wiley.com/10.1002/pros.23721
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http://dx.doi.org/10.1002/pros.23721DOI Listing
February 2019
21 Reads

Inefficient N2-Like Neutrophils Are Promoted by Androgens During Infection.

Front Immunol 2018 3;9:1980. Epub 2018 Sep 3.

Centro de Microscopía Electrónica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Neutrophils are major effectors of acute inflammation against infection and tissue damage, with ability to adapt their phenotype according to the microenvironment. Although sex hormones regulate adaptive immune cells, which explains sex differences in immunity and infection, little information is available about the effects of androgens on neutrophils. We therefore aimed to examine neutrophil recruitment and plasticity in androgen-dependent and -independent sites under androgen manipulation. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129603PMC
September 2018
3 Reads

[Fosfomycin tromethamine inhibits the expressions of TNF-α, IL-8 and IL-6 in the prostate tissue of rats with chronic bacterial prostatitis].

Zhonghua Nan Ke Xue 2018 Jun;24(6):491-498

Department of Andrology, Jinling Hospital Affiliated to Southern Medical University / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.

Objective: To investigate the effects of fosfomycin tromethamine (FT) on the expressions of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and interleukin-6 (IL-6) in the prostate tissue of the rats with chronic bacterial prostatitis (CBP).

Methods: We randomly divided 70 male SD rats into 7 groups of equal number: blank control, CBP model control, positive control, 14 d low-dose FT, 7 d low-dose FT, 14 d high-dose FT, and 7 d high-dose FT. The CBP model rats in the latter five groups were treated intragastrically with levofloxacin at 100 mg/kg/d for 30 days and FT at 200 mg/kg/d for 14 and 7 days and at 300 mg/kg/d for 14 and 7 days, respectively. Read More

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June 2018
21 Reads

Differentially Enhancing Effects of Long-term Treatment with Serrazyme, Boswellia and Pine on Seminal Bacterial Detection in Patients with Chronic Bacterial or Inflammatory Prostatitis, Probably Related to Several Degrees of Bacterial Adherence.

Curr Clin Pharmacol 2018 ;13(3):183-189

Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.

Background: Prostatitis is a recurrent urinary infection in males and is often difficult to cure. The aim of the study was to examine whether anti-inflammatory effects of enhanced drainage of prostatic secretions, obtained through two months treatment with a proteolytic enzyme mucoactive (PEM) compound (Serrazyme and other constituents), influenced qualitative or quantitative expressions of bacterial growth in seminal cultures.

Method: 450 patients with prostatitis syndromes were randomized either to PEM therapy (intervention group) or to no treatment group. Read More

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http://dx.doi.org/10.2174/1574884713666180803114654DOI Listing
January 2018
8 Reads

The Urinary Tract Microbiome: The Answer to All Our Open Questions?

Eur Urol Focus 2019 01 2;5(1):36-38. Epub 2018 Jul 2.

Department of Urology, Ludwig-Maximilians-Universität, Munich, Germany.

Context: The dogma of a sterile urinary tract persisted for over a century. With the advances in new high-throughput sequencing technologies and modified culture protocols for microbiome research, we have discovered a variable microbial spectrum in the urinary tract. Its relevance for health and disease is now under investigation. Read More

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http://dx.doi.org/10.1016/j.euf.2018.06.011DOI Listing
January 2019
2 Reads

Phage Therapy in Prostatitis: Recent Prospects.

Front Microbiol 2018 29;9:1434. Epub 2018 Jun 29.

Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States.

Prostatitis has various etiology including bacterial infection and dysregulated immunity; some of its forms remain a serious therapeutic challenge. Inflammation occurs in all forms of this disorder and is proposed to predispose to the development of prostate cancer (PC). There are reports that phage therapy is effective in chronic bacterial prostatitis. Read More

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http://dx.doi.org/10.3389/fmicb.2018.01434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034095PMC
June 2018
5 Reads

Canine Prostate Disease.

Vet Clin North Am Small Anim Pract 2018 Jul;48(4):701-719

Kokopelli Assisted Reproductive Services, Franklin Ranch Pet Hospital, 10207 Franklin Boulevard, Elk Grove, CA 95757, USA. Electronic address:

All intact, male dogs will experience benign prostatic hyperplasia and hypertrophy, usually by around 6 years old. Although these dogs will be predisposed to prostatic infections, only a small subset will actually develop infections or show clinical signs of discomfort or subfertility. Neutered male dogs have a higher incidence of neoplasia associated with the prostate. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.02.012DOI Listing
July 2018
14 Reads

An implementation of next generation sequencing for prevention and diagnosis of urinary tract infection in urology.

Can J Urol 2018 06;25(3):9349-9356

Central Florida Cancer Institute, Davenport; Nova Southeastern University, Fort Lauderdale, Florida, USA.

Introduction: The changing face of current infection phenotypes from planktonic to biofilm type has been developed implicating bacterial biofilms in recurrent infection. To date, no specific medical treatment exists to specifically target biofilms in the human host. Similarly, the identification of a biofilm has relied upon the analysis of tissue samples with electron microscopy or DNA identification with polymerase chain reaction (PCR) and sequencing. Read More

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June 2018
6 Reads

Stopping the effective non-fluoroquinolone antibiotics at day 7 vs continuing until day 14 in adults with acute pyelonephritis requiring hospitalization: A randomized non-inferiority trial.

PLoS One 2018 16;13(5):e0197302. Epub 2018 May 16.

Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Objective: To evaluate whether stopping the effective antibiotic treatment following clinical improvement at Day 7 (Truncated treatment) would be non-inferior to continued treatment until Day 14 (Continued treatment) in patients with acute pyelonephritis (APN) requiring hospitalization treated with non-fluoroquinolone (non-FQ) antibiotics.

Methods: Hospitalized adult men and non-pregnant women with culture-confirmed APN were eligible for participation after they had clinically improved following empirical or culture-guided treatment with intravenous non-FQ antibiotic(s). We excluded patients with severe sepsis, abscesses, prostatitis, recurrent or catheter-associated urinary tract infection, or urinary tract obstruction. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197302PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955556PMC
December 2018
4 Reads

Practice guidelines for the management of adult community-acquired urinary tract infections.

Med Mal Infect 2018 08 16;48(5):327-358. Epub 2018 May 16.

Maladies infectieuses, groupe de recherche sur l'adaptation microbienne (EA2656), université de Normandie, CHU de Rouen, 76000 Rouen, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0399077X173103
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http://dx.doi.org/10.1016/j.medmal.2018.03.005DOI Listing
August 2018
19 Reads

Graminex Pollen: Phenolic Pattern, Colorimetric Analysis and Protective Effects in Immortalized Prostate Cells (PC3) and Rat Prostate Challenged with LPS.

Molecules 2018 May 11;23(5). Epub 2018 May 11.

Department of Pharmacy, G. D'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.

Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents. The efficacy of herbal extracts with antioxidant and anti-inflammatory effects for blunting the burden of inflammation and oxidative stress, with possible improvements in clinical symptoms, is under investigation. Pollen extracts have been previously reported as promising agents in managing clinical symptoms related to prostatitis. Read More

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http://www.mdpi.com/1420-3049/23/5/1145
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http://dx.doi.org/10.3390/molecules23051145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100541PMC
May 2018
10 Reads

Prostate calcifications: A case series supporting the microbial biofilm theory.

Investig Clin Urol 2018 05 4;59(3):187-193. Epub 2018 Apr 4.

Department of Urology, Oslo University Hospital, Oslo, Norway.

Purpose: Prostate calcifications are a common finding during transrectal prostate ultrasound in both healthy subjects and patients, but their etiopathogenesis and clinical significance are not fully understood. We aimed to establish a new methodology for evaluating the role of microbial biofilms in the genesis of prostate calcifications.

Materials And Methods: Ten consecutive patients who had undergone radical prostatectomy were enrolled in this study. Read More

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http://dx.doi.org/10.4111/icu.2018.59.3.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934281PMC
May 2018
4 Reads

Ageing and inflammation in the male reproductive tract.

Andrologia 2018 Dec 8;50(11):e13034. Epub 2018 May 8.

Instituto de Biología y Medicina Experimental, CONICET, Ciudad de Buenos Aires, Argentina.

Ageing is usually characterised by a mild chronic proinflammatory state. Despite the tight association between both processes, the phenomenon has recently been termed inflammageing. Inflammation in the male reproductive tract is frequently linked with bacterial or virus infections but also with a broad range of noninfectious processes. Read More

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http://dx.doi.org/10.1111/and.13034DOI Listing
December 2018
1 Read

Bacteremia and meningitis caused by OXA-23-producing Acinetobacter baumannii - molecular characterization and susceptibility testing for alternative antibiotics.

Braz J Microbiol 2018 Nov 24;49 Suppl 1:199-204. Epub 2018 Apr 24.

Instituto de Pesquisa Pele Pequeno Principe, Curitiba, PR, Brazil; Universidade Federal do Paraná, Hospital de Clinicas, Curitiba, PR, Brazil.

Background: Carbapenem-resistant Acinetobacter baumannii infection is a concern in developing countries due to high incidence, few therapeutic options, and increasing costs.

Objective: Characterize and analyze the antibiotic susceptibility patterns of carbapenem-resistant A. baumannii isolates and evaluate clinical data of meningitis and bacteremia caused by this microorganism. Read More

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http://dx.doi.org/10.1016/j.bjm.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328846PMC
November 2018
1 Read

Pharmacodynamic and pharmacokinetic studies and prostatic tissue distribution of fosfomycin tromethamine in bacterial prostatitis or normal rats.

Andrologia 2018 Aug 2;50(6):e13021. Epub 2018 May 2.

School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.

In this study, we assessed the therapeutic effects of fosfomycin tromethamine (FT) in a bacterial prostatitis (BP) rat model. The BP model was induced by Escherichia coli and was demonstrated after 7 days microbiologically and histologically. Then, 25 BP rats selected were randomly divided into five treatment groups: model group, positive group, FT-3 day group, FT-7 day group and FT-14 day group. Read More

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http://dx.doi.org/10.1111/and.13021DOI Listing
August 2018
6 Reads

[Triple acupuncture at the Qugu acupoint as an adjunctive therapy for type-Ⅲ chronic prostatitis: Analysis of short- and long-term clinical effects].

Zhonghua Nan Ke Xue 2017 May;23(5):464-467

Department of Andrology, Guang'anmen Hospital (South Section), Chinese Academy of Chinese Medical Sciences, Beijing 102638, China.

Objective: To investigate the short- and long-term effects of triple acupuncture at the Qugu acupoint as an adjunctive therapy on type-Ⅲ chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS).

Methods: We equally randomized 90 CP/CPPS patients into a control and a treatment group, both treated with Levofloxacin Mesylate Tablets (0.5 g, tid) + Terazosin Hydrochloride Capsules (2 mg qd) for 4 weeks, while the latter group by triple acupuncture at the Qugu acupoint as an adjunctive therapy twice a week at the same time. Read More

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May 2017
15 Reads

Acupuncture for chronic prostatitis: A systematic review and meta-analysis protocol.

Medicine (Baltimore) 2018 Apr;97(17):e0615

Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China.

Background: Chronic prostatitis (CP) is a prevalent genitourinary condition. Considering its safety profile, acupuncture can be an option treating CP symptoms. The aim of this review is to undertake a systematic review to estimate the effectiveness and safety of acupuncture on CP. Read More

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http://dx.doi.org/10.1097/MD.0000000000010615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944557PMC
April 2018
8 Reads

Computer-Assisted Quantitative Assessment of Prostatic Calcifications in Patients with Chronic Prostatitis.

Urol Int 2018 26;100(4):450-455. Epub 2018 Apr 26.

Urology Unit, Manzoni Hospital, Lecco, Italy.

Background: The aim of this study was the development of quantitative assessment of prostatic calcifications at prostatic ultrasound examination by the use of an image analyzer.

Materials And Methods: A group of 82 patients was evaluated by medical history, physical, and transrectal ultrasound examination. Patients had a urethral swab, a 4-specimen study and culture of the seminal fluid. Read More

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http://dx.doi.org/10.1159/000486346DOI Listing
January 2019
10 Reads

[Successful Antibiotic Treatment of Lumbar Pain].

Praxis (Bern 1994) 2018 Apr;107(9-10):535-544

1 Medbase St. Gallen, Am Vadianplatz, St. Gallen.

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http://dx.doi.org/10.1024/1661-8157/a002965DOI Listing
April 2018
5 Reads

New Bacterial Infection in the Prostate after Transrectal Prostate Biopsy.

Authors:
Yumi Seo Gilho Lee

J Korean Med Sci 2018 Apr 6;33(17):e126. Epub 2018 Apr 6.

Department of Urology, Dankook University College of Medicine, Cheonan, Korea.

Background: The prostate is prone to infections. Hypothetically, bacteria can be inoculated into the prostate during a transrectal prostate biopsy (TRPB) and progress into chronic bacterial prostatitis. Therefore, we examined new bacterial infections in biopsied prostates after TRPB and whether they affect clinical characteristics in the biopsied patients. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2018.3
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http://dx.doi.org/10.3346/jkms.2018.33.e126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909103PMC
April 2018
33 Reads

Acute bacterial prostatitis in an adolescent patient following blunt trauma.

Proc (Bayl Univ Med Cent) 2018 Jan 1;31(1):107-108. Epub 2018 Feb 1.

Department of Radiology, University Medical Center, Lubbock, Texas.

Acute bacterial prostatitis is a common disease among adults. Acute bacterial prostatitis in the pediatric population is rare with only a few case reports in the literature. This case highlights an unusual presentation of prostatitis in a 16-year-old who presented with suprapubic pain and hematuria following blunt trauma to the lower abdomen. Read More

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http://dx.doi.org/10.1080/08998280.2017.1400881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903498PMC
January 2018
2 Reads

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy.

Nat Commun 2018 04 23;9(1):1591. Epub 2018 Apr 23.

Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

Immune checkpoint inhibitors have not been effective for immunologically "cold" tumors, such as prostate cancer, which contain scarce tumor infiltrating lymphocytes. We hypothesized that select tissue-specific and immunostimulatory bacteria can potentiate these immunotherapies. Here we show that a patient-derived prostate-specific microbe, CP1, in combination with anti-PD-1 immunotherapy, increases survival and decreases tumor burden in orthotopic MYC- and PTEN-mutant prostate cancer models. Read More

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http://dx.doi.org/10.1038/s41467-018-03900-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913311PMC
April 2018
26 Reads

Assessment of antimicrobiral prophylaxis in transperineal prostate biopsy: A single-center retrospective study of 485 cases.

J Infect Chemother 2018 Aug;24(8):637-640

Department of Urology, Gunma University Hospital, Japan.

To verify the validity of our antimicrobial prophylaxis regimen for transperineal prostate biopsies, we investigated the rate of infectious complications in this procedure. We retrospectively investigated the infectious complications in 485 patients who underwent a transperineal prostate biopsy between 2014 and 2016 at our hospital. In the clinic, we use cefazolin (CEZ) for antimicrobial prophylaxis. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.03.014DOI Listing
August 2018
36 Reads