2,030 results match your criteria Prostatitis Bacterial

How I manage bacterial prostatitis.

Clin Microbiol Infect 2022 Jun 13. Epub 2022 Jun 13.

Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.

Background: Bacterial prostatitis is a highly prevalent infection responsible for significant morbidity among men. The diagnosis and treatment for bacterial prostatitis remains complicated. The difficulty in diagnosis is in part owing to the paucity of high quality evidence that guides a clinician's physical examination and informs interpretation of laboratory data in confirming patients' history. Read More

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Improvement of chronic non-bacterial prostatitis by Jiedu Huoxue decoction through inhibiting TGF-β/SMAD signaling pathway.

Biomed Pharmacother 2022 Aug 2;152:113193. Epub 2022 Jun 2.

Department of Traditional Chinese Medicine Surgery, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, No. 445 Bayi Avenue, Nanchang 330006, China. Electronic address:

Background: Chronic non-bacterial prostatitis (CNBP) accounts for more than 90 % of clinical prostatitis cases, and there is no specific and effective treatment for CNBP. The regulatory role of Jiedu Huoxue decoction (JDHXD)in CNBP remains unclear. We investigated if JDHXD could improve CNBP METHODS: The animal model of CNBP was established by carrageenan injection with 1 % carrageenan (50 μL). Read More

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Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of in Rats.

Molecules 2022 May 19;27(10). Epub 2022 May 19.

Xinjiang Key Laboratory for Reserch of Licorice and Products, Korla 841011, China.

(1) Background: The aerial part of had pharmacological effects against chronic non-bacterial prostatitis (CNP), and flavonoids are the main efficacy components. The purpose of this study was to obtain the pharmacokinetics, prostate distribution and metabolic characteristics of some flavonoids in rats. (2) Methods: The prototype flavones and the metabolites of four representative flavonoids, namely puerarin, luteolin, kaempferol and pinocembrin in plasma, prostate, urine and feces of rats were analyzed by UPLC-Q-Exactive Orbitrap-MS. Read More

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Loss of the Sympathetic Signal Produces Sterile Inflammation of the Prostate.

Front Mol Neurosci 2022 10;15:855376. Epub 2022 May 10.

Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Neural innervations exert essential roles in the prostate. However, spatial distribution and regulatory function of such neural inputs are incompletely characterized. Here, we exploited the advanced whole-tissue immunolabeling and optical clearing technique to assess the 3D anatomy of autonomic innervations in the mouse and human prostate for the first time. Read More

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Pharmacotherapeutic interventions for the treatment of bacterial prostatitis.

Expert Opin Pharmacother 2022 Jun 27:1-11. Epub 2022 Jun 27.

Department of Infectious Diseases, Vall d'Hebron Hospital Universitari, Barcelona, Spain.

Introduction: Bacterial prostatitis, acute or chronic, is one of the most prevalent urogenital infections in men. Its diagnosis requires the application of a careful methodology. Gram-negative bacilli are the most frequent causative agents, and in recent years, an increase in the frequency of multiresistant bacteria has been detected. Read More

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Coupling of Inflammation and Microcalcification in the Pathogenesis of Prostate Calculi: Detection Using 18F-NaF and 18F-FDG PET/CT.

Clin Nucl Med 2022 May 11. Epub 2022 May 11.

From the Department of Radiology, Hospital of the University of Pennsylvania.

Abstract: Prostatic calculi are common and usually asymptomatic calcified stones frequently found incidentally in imaging or during the evaluation of benign prostatic hyperplasia. Those associated with chronic prostatitis can lead to bacterial colonization, inflammation, and blockage of secretory ducts, resulting in pelvic pain and lower urinary tract symptoms. Although PET tracers such as 18F-NaF and 18F-FDG have been used to assess metastatic and benign bone disorders, their comparative avidity in the domain of extraosseous and prostate calcification remains to be fully explored. Read More

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Bacterial urinary tract infection and subclinical bacteriuria in dogs receiving antineoplastic chemotherapy.

J Vet Intern Med 2022 May 7;36(3):1005-1015. Epub 2022 May 7.

Clinic of Small Animal Internal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian-University, Munich, Germany.

Background: Immunosuppressive treatment with glucocorticoids and cyclosporine increases the risk for positive urine cultures (PUCs) in dogs.

Objective: To investigate the prevalence and incidence of PUC in dogs diagnosed with cancer and treated with antineoplastic chemotherapy while distinguishing between subclinical bacteriuria (SB) and urinary tract infection (UTI).

Animals: Forty-six client-owned dogs with nonurogenital cancer treated with antineoplastic chemotherapy. Read More

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Prostate diseases and microbiome in the prostate, gut, and urine.

Prostate Int 2022 Jun 29;10(2):96-107. Epub 2022 Mar 29.

Department of Urology, Kashihara, Nara, 634-8522, Japan.

The microbiome in various organs involves a vast network that plays a key role in the health and wellness of the human body. With recent advances in biological technologies such as high-throughput sequencing, transcriptomics, and metabolomics, it appears that the microbial signature varies dynamically among individuals, creating various roles in metabolism, local and systemic inflammation, and host immunity. Urinary and genital organs, including the prostate, seminal vesicles, and urinary bladder, are reservoirs of several bacterial, viral, and fungal communities. Read More

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Urinary Tract Infections Treatment/Comparative Therapeutics.

Vet Clin North Am Small Anim Pract 2022 May;52(3):581-608

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA.

Urinary tract infection (UTI) is commonly encountered in small animal general practice. Within the past 5 years, there have been changes to terminology, such as the renaming of asymptomatic bacteriuria to subclinical bacteriuria, as well as paradigm shifts in the management of UTI. In general, there is an emphasis for responsible antimicrobial stewardship and selecting treatment based on urine culture and sensitivity and treating symptomatic bacterial UTI with a shorter duration of antimicrobials. Read More

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Morphological study of chronic prostatitis-chronic pelvic pain syndrome (CP/CPPS) normal modeling dose of T2 peptide in mice.

Int Urol Nephrol 2022 Jun 19;54(6):1199-1206. Epub 2022 Apr 19.

Department of Gastrointestinal Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No.98 Nantong West Road, Yangzhou, 225001, Jiangsu Province, China.

Objectives: However, the pathogenesis and etiology of CP/CPPS are still poorly understood. Therefore, there is a need for further research through the Image J software to develop models capable of imitating the pathogenesis and etiology of CP/CPPS with different doses of the pathogenesis and the etiology of CP/CPPS is still poorly understood. The aim was to determine the area of the prostatic interstitium, the localization of the inflammation, and the impact of different doses on the group model. Read More

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Antibiotic therapy of chronic bacterial prostatitis is more effective considering antibiotic susceptibility of all pathogens isolated.

Investig Clin Urol 2022 05 5;63(3):325-333. Epub 2022 Apr 5.

Department of Urology, Technical University of Munich School of Medicine, Munich, Germany.

Purpose: Because of the insufficient efficacy of the current treatment of chronic bacterial prostatitis (CBP), it is justified to search for a more effective antibiotic therapy (ABT).

Materials And Methods: This single-centre prospective observational comparative study was conducted in 2012 to 2019 (patients: 60 men with CBP; age: 20-45 y). The clinical examination was performed on admission and at 1, 3, 6, or 12 months. Read More

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Cross-sectional study on the etiological diagnosis of the patients with chronic prostatitis-like symptoms by application of the urine-prostate-semen test.

Danni Wang He Wang

Health Sci Rep 2022 Apr 1;5(3):e574. Epub 2022 Apr 1.

Department of Microbiology Guizhou Medical University Guiyang Guizhou China.

Background And Aims: The prostatic secretion was considered to be the most important and even only specimen in diagnosis and differential diagnosis of chronic prostatitis like symptoms, but little attention has been paid to other genital organ infections. A urine-prostate-semen test (U-EPS-S test) was used to investigate the microbial flora of internal genital organs in patients with chronic prostatitis-like symptoms and their influence on the diagnosis and treatment of the patients.

Materials And Methods: We randomly selected the patients with chronic prostatitis-like symptoms for this study and used a U-EPS-S test to collect urine, prostatic secretion, and semen specimens. Read More

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A preliminary study on the diagnostic value of PSADR, DPC and TSRP in the distinction of prostatitis and prostate cancer.

BMC Cancer 2022 Mar 31;22(1):348. Epub 2022 Mar 31.

Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157 Xiwu Road, Xincheng District, Xi'an, 710004, Shaanxi, China.

Background: The purpose of this study was to investigate the ability of differential diagnosis of prostate specific antigen decline rate (PSADR) per week, degree of prostatic collapse (DPC) and tissue signal rate of prostate (TSRP) between prostatitis and prostate cancer.

Methods: The clinical data of 92 patients [prostate specific antigen (PSA) > 10 ng/mL] who underwent prostate biopsy in the Department of Urology, the Second Affiliated Hospital of Xi 'an Jiaotong University from May 2017 to April 2020 were reviewed retrospectively. They were divided into two groups, prostatitis group (n = 42) and prostate cancer (PCa) group (n = 50), according to pathological results. Read More

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Diagnostic cytokine marker of male infertility - interleukin 4.

Klin Lab Diagn 2022 Mar;67(3):151-157

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences, separate subdivision OFRC, Ural Branch of the Russian Academy of Sciences.

Analysis of the study is to assess the diagnostic significance of cytokines in the sperm plasma of men of reproductive age (20 - 45 years) of two groups: of patients with chronic bacterial prostatitis, not complicated by infertility and with loss of fertility. The study of sperm plasma - the WHO standard. Determination of the level of cytokines in seminal plasma - by enzyme immunoassay («Cytokine», Russia). Read More

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Antimicrobial Treatment Options for Difficult-to-Treat Resistant Gram-Negative Bacteria Causing Cystitis, Pyelonephritis, and Prostatitis: A Narrative Review.

Drugs 2022 Mar 14;82(4):407-438. Epub 2022 Mar 14.

Center for Quality, Effectiveness, and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.

Urinary tract infections, including cystitis, acute pyelonephritis, and prostatitis, are among the most common diagnoses prompting antibiotic prescribing. The rise in antimicrobial resistance over the past decades has led to the increasing challenge of urinary tract infections because of multidrug-resistant and "difficult-to-treat resistance" among Gram-negative bacteria. Recent advances in pharmacotherapy and medical microbiology are modernizing how these urinary tract infections are treated. Read More

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Antibiotic-loaded reactive oxygen species-responsive nanomedicine for effective management of chronic bacterial prostatitis.

Acta Biomater 2022 04 5;143:471-486. Epub 2022 Mar 5.

Department of Urology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China. Electronic address:

Chronic bacterial prostatitis (CBP) occurs frequently in the male population and significantly influences quality of life. Antibiotics are the main strategy for managing chronic bacterial prostatitis; however, most antibiotics have low efficacy due to their poor penetration of prostate tissues. To overcome this challenge, we fabricated cefpodoxime proxetil (CPD)-loaded reactive oxygen species (ROS)-responsive nanoparticles (NPs) for targeted treatment of CBP. Read More

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Point-of-care urine Gram stain led to narrower-spectrum antimicrobial selection for febrile urinary tract infection in adolescents and adults.

BMC Infect Dis 2022 Mar 1;22(1):198. Epub 2022 Mar 1.

Division of Infectious Diseases, Department of Internal Medicine, Okinawa Chubu Hospital, 281 Miyazato, Uruma, Okinawa, 904-2293, Japan.

Background: Febrile urinary tract infections (fUTIs), which include pyelonephritis, prostatitis, and urosepsis, are the most common cause of sepsis. However, the treatment has become more complex because of the worldwide increase in antimicrobial resistance (AMR). The objective of this study was to clarify whether point-of-care Gram stain (PCGS) of urine contributed to fUTI diagnosis and treatment in adults. Read More

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Efficacy and Safety of Oral Fosfomycin-Trometamol in Male Urinary Tract Infections with Multidrug-Resistant Enterobacterales.

Antibiotics (Basel) 2022 Feb 3;11(2). Epub 2022 Feb 3.

Tropical and Infectious Diseases Department, Hospital Nord Franche-Comté, 90400 Trévenans, France.

Background: Antimicrobial drugs to treat male urinary tract infection (UTI) with multidrug-resistant Enterobacterales are limited. We studied oral fosfomycin-trometamol (FT) in this situation. The objective was to assess the clinical cure rate in patients presenting UTIs treated with oral FT. Read More

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February 2022

The Translational Role of Animal Models for Estrogen-Related Functional Bladder Outlet Obstruction and Prostatic Inflammation.

Vet Sci 2022 Jan 31;9(2). Epub 2022 Jan 31.

Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland.

The prevalence of LUTS and prostatic diseases increases with age both in humans and companion animals, suggesting that a common underlying cause of these conditions may be age-associated alterations in the balance of sex hormones. The symptoms are present with different and variable micturition dysfunctions and can be assigned to different clinical conditions including bladder outlet obstruction (BOO). LUTS may also be linked to chronic non-bacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS), but the relationship between these conditions is unknown. Read More

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January 2022

Prostatitis and prostatic abscessation in dogs: retrospective study of 82 cases.

Aust Vet J 2022 Jun 17;100(6):223-229. Epub 2022 Feb 17.

Department of Internal Medicine, Southern Counties Veterinary Specialists, Ringwood, UK.

Objectives: To describe clinical signs, diagnostics, treatments and outcomes of prostatitis and prostatic abscesses of dogs in a referral population.

Animals: Eighty-two dogs diagnosed with prostatitis and/or prostatic abscesses from three referral hospitals.

Procedures: Retrospective case series. Read More

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Exploring the molecular mechanism of action of Polygonum capitatum Buch-Ham. ex D. Don for the treatment of bacterial prostatitis based on network pharmacology and experimental verification.

J Ethnopharmacol 2022 Jun 9;291:115007. Epub 2022 Feb 9.

Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 69 Zengchan Road, Hebei District, Tianjin, 300250, China. Electronic address:

Ethnopharmacology Relevance: Polygonum capitatum Buch-Ham. ex D. Don (CNPC2009), a traditional Miao-national herbal medicine, has been widely used with considerable therapeutic efficacy in the treatment of various urologic disorders including prostatitis. Read More

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Post-prostate biopsy acute bacterial prostatitis and screening cultures using selective media: An overview.

Int J Urol 2022 06 10;29(6):486-493. Epub 2022 Feb 10.

Department of Urology, Shimane University Faculty of Medicine, Shimane, Japan.

The development of several culture media and the availability to isolate and treat pathogens prior to a surgical procedure give us the ability to minimize treatment-related complications, and ultimately results in better outcomes for patients and avoidance of unwanted post-procedure inpatient admissions. In the last decade, an increasing incidence of multidrug-resistant Escherichia coli, especially extended-spectrum beta-lactamase-producing E. coli and fluoroquinolone-resistant pathogens, has been reported. Read More

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Multi-Omics Analysis Reveals Changes in the Intestinal Microbiome, Transcriptome, and Methylome in a Rat Model of Chronic Non-bacterial Prostatitis: Indications for the Existence of the Gut-Prostate Axis.

Front Physiol 2021 11;12:753034. Epub 2022 Jan 11.

Department of Food Science and Engineering, Jinan University, Guangzhou, China.

Chronic non-bacterial prostatitis (CNP) is one of the most prevalent diseases in human males worldwide. In 2005, the prostate-gut axis was first proposed to indicate the close relationship between the prostate and the intestine. This study investigated CNP-induced changes of the gut microbiota, gene expression and DNA methylation in a rat model by using multi-omics analysis. Read More

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January 2022

A retrospective review of canine benign prostatic hyperplasia with and without prostatitis.

Clin Theriogenology 2021 Dec;13(4):360-366

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.

Benign prostatic hyperplasia (BPH) is the most common prostatic disorder in older intact male dogs, but despite its prevalence, there are inconsistencies in clinical diagnosis and treatment. Although prostate size was historically considered the hallmark feature of BPH in men, currently, there is only a weak correlation between prostate size and clinical severity. We performed a retrospective cohort study with the primary objective of assessing clinical signs, ultrasonographic findings, treatments, and outcomes in dogs diagnosed with BPH, with and without concurrent prostatitis. Read More

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December 2021

Ceftriaxone for the Treatment of Chronic Bacterial Prostatitis: A Case Series and Literature Review.

Antibiotics (Basel) 2022 Jan 11;11(1). Epub 2022 Jan 11.

Department of Internal Medicine, Haga Teaching Hospital, 2545 AA The Hague, The Netherlands.

Chronic bacterial prostatitis is increasingly difficult to treat due to rising antimicrobial resistance limiting oral treatment options. In this case series, 11 men with CBP (including patients with urological comorbidities) due to multi-resistant were treated with once-daily ceftriaxone intravenously for 6 weeks. Nine patients were clinically cured at 3 months follow up. Read More

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January 2022

associated hematogenous sternoclavicular joint osteomyelitis: A rare condition with a rare causative pathogen.

IDCases 2022 6;27:e01381. Epub 2022 Jan 6.

Edward Hines, Jr. VA Hospital, Department of Internal Medicine, 5000 5th Ave, Hines, IL 60141, USA.

is the most common microorganism that causes urinary tract infections (UTIs), including acute prostatitis. However, osteomyelitis, especially ones that involve the sternoclavicular joint, are rare hematogenous complications. We present a case of an immunocompetent man who presented with symptoms of UTI and right shoulder pain. Read More

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January 2022

Probable ertapenem-induced encephalopathy; case report and suggested alternatives for chronic prostatitis.

Daru 2022 Jun 13;30(1):159-163. Epub 2022 Jan 13.

Unidad de Gestión Clínica de Farmacia, Hospital Universitario Virgen del Rocío/CSIC, Instituto de Biomedicina de Sevilla (IBiS), 41009, Seville, Spain.

Ertapenem is a carbapenem antibiotic usually reserved for complicated infections. Drug-induced neurotoxicity is a rare adverse reaction associated with ertapenem, and may be directly related to its chemical structure. We report a case of a 64-year-old male with a hematological history and chronic prostatitis that was admitted to hospital for gait instability, clumsiness, dysarthria and tremors. Read More

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Is clindamycin a potential treatment for prostatitis?

APMIS 2022 Apr 9;130(4):197-205. Epub 2022 Feb 9.

College of Pharmacy, University of Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil.

Cutibacterium acnes has been associated with chronic prostatitis, which can potentially favor the appearance of tumors in the prostate. Prostatitis is difficult to treat, and the drug needs to be able to penetrate the prostate. The aim was to investigate the pharmacokinetics of clindamycin in the interstitial fluid of rat prostate using microdialysis. Read More

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[The use of rectal suppositories with oxidised dextran for calculous prostatitis].

Urologiia 2021 12(6):127-129

Federal Medical Research Centre of Fundamental and Translational Medicine, Novosibirsk, Russia.

This article presents its own experience of using suppositories with oxidised dextran in the treatment of a patient with recurrent bacterial prostatitis complicated by prostate calcifications, these are the positive effects on the use of suppositories with oxidised dextran: a decrease in the size of calcified areas, a stable elimination of opportunistic microflora and the achievement of long-term remission of the disease. Read More

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December 2021

Dihydroartemisinin Promoted Bone Marrow Mesenchymal Stem Cell Homing and Suppressed Inflammation and Oxidative Stress against Prostate Injury in Chronic Bacterial Prostatitis Mice Model.

Evid Based Complement Alternat Med 2021 15;2021:1829736. Epub 2021 Dec 15.

Department of Urology, Shijiazhuang City People's Hospital, Shijiazhuang 050000, Hebei, China.

Although bone marrow mesenchymal stem cells (BMMSCs) are effective in treating chronic bacterial prostatitis (CBP), the homing of BMMSCs seems to require ultrasound induction. Dihydroartemisinin (DHA) is an important derivative of artemisinin (ART) and has been previously reported to alleviate inflammation and autoimmune diseases. But the effect of DHA on chronic prostatitis (CP) is still unclear. Read More

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December 2021