1,905 results match your criteria Prostatitis Bacterial


[New opportunities of using gialuronidase in chronic prostatitis].

Urologiia 2020 Jun(3):56-62

TB Research Institute of Ministry of Health of Russia, Novosibirsk, Russia.

Introduction: The use of hyaluronidase contributes to improvement in microcirculation, destruction of biofilms and reducing of congestion in patients with chronic prostatitis. Based on this mechanism, the use Longidaza for the diagnosis of latent bacterial prostatitis was suggested.

Aim: To evaluate diagnostic and treatment capabilities of the long-acting enzyme preparation Longidaza (rectal suppositories with an activity of 3000 IU), prescribed to patients with chronic prostatitis in routine clinical practice. Read More

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Management of Chronic Bacterial Prostatitis.

Curr Urol Rep 2020 Jun 3;21(7):29. Epub 2020 Jun 3.

The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, 301 Building, Suite 3112, Baltimore, MD, 21224, USA.

Purpose Of Review: We conducted a review of the literature describing the most up-to-date diagnosis and treatment options of chronic bacterial prostatitis.

Recent Findings: Recurrence after oral antimicrobial therapy is common, due in part to the rising rates of antimicrobial resistance and inability to completely clear the offending bacteria from the prostate following prostatitis. Recent literature has described various treatment options for chronic bacterial prostatitis refractory to conventional antimicrobial agents, including the use of alternative agents such as fosfomycin, direct antimicrobial injections into the prostate, surgical removal of infected prostatic tissue, chronic oral antibiotic suppression, and an emerging novel therapy utilizing bacteriophages to target antibiotic resistant bacteria. Read More

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http://dx.doi.org/10.1007/s11934-020-00978-zDOI Listing

Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis.

Int J Mol Sci 2020 May 31;21(11). Epub 2020 May 31.

Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.

Non-bacterial prostatitis is an inflammatory disease that is difficult to treat. Oligonucleotide aptamers are well known for their stability and flexibility in conjugating various inflammatory molecules. In this study, we investigated the effects of inflammatory cytokine-targeting aptamers (ICTA), putative neutralizers of TNF-alpha and IL-1 beta activation, on local carrageenan-induced prostate inflammation, allodynia, and hyperalgesia in rats. Read More

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http://dx.doi.org/10.3390/ijms21113953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312664PMC

[Consenso Argentino Intersociedades de Infección Urinaria 2018-2019 - Parte I].

Medicina (B Aires) 2020 ;80(3):229-240

Sociedad Argentina de Infectología, Argentina.

The Argentine Society of Infectious Diseases and other scientific societies have updated these recommendations based on data on urinary tract infections in adults obtained from a prospective multicenter study conducted in Argentina during 2016-2017. Asymptomatic bacteriuria should be treated only in pregnant women, who should also be systematically investigated; the antibiotics of choice are nitrofurantoin, amoxicillin, clavulanic/amoxicillin, cephalexin and trimethoprim-sulfamethoxazole. In procedures involving injury to the urinary tract with bleeding, it is recommended to request urine culture and, in the presence of bacteriuria, antimicrobial treatment according to sensitivity should be prescribed from immediately before up to 24 hours after the intervention. Read More

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June 2020
0.421 Impact Factor

Pharmacological Interventions for Bacterial Prostatitis.

Front Pharmacol 2020 30;11:504. Epub 2020 Apr 30.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Prostatitis is a common urinary tract condition but bring innumerable trouble to clinicians in treatment, as well as great financial burden to patients and the society. Bacterial prostatitis (acute bacterial prostatitis plus chronic bacterial prostatitis) accounting for approximately 20% among all prostatitis have made the urological clinics complain about the genital and urinary systems all over the world. The international challenges of antibacterial treatment (emergence of multidrug-resistant bacteria, extended-spectrum beta-lactamase-producing bacteria, bacterial biofilms production and the shift in bacterial etiology) and the transformation of therapeutic strategy for classic therapy have attracted worldwide attention. Read More

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http://dx.doi.org/10.3389/fphar.2020.00504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203426PMC

Analysis of bacterial community using pyrosequencing in semen from patients with chronic pelvic pain syndrome: a pilot study.

Transl Androl Urol 2020 Apr;9(2):398-404

Department of Urology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Although empirical antibacterial treatments are currently recommended for inflammatory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), physicians cannot verify infections in most cases. Therefore, in this study, the microbiota of semen was investigated via pyrosequencing to obtain evidence underlying infectious disease.

Methods: Patients diagnosed with CP/CPPS (n=17) and healthy volunteers (n=4) participated in the study. Read More

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http://dx.doi.org/10.21037/tau.2020.02.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215052PMC

[Use of Nordic walking in the complex treatment of lower urinary tract symptoms in chronic prostatitis].

Vopr Kurortol Fizioter Lech Fiz Kult 2020 ;97(2):45-51

Ural State Medical University, Ekaterinburg, Russia.

Introduction: Lower urinary tract symptoms (LUTS) caused by chronic prostatitis (CP) are a common condition. Standard antibiotic therapy is often not justified, since bacterial prostatitis is presented in up to 10% of the cases, while there is no effect on the risk factors for the development and relapse of the disease. This study is aimed at one of the main risk factors for LUTS - a sedentary lifestyle. Read More

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http://dx.doi.org/10.17116/kurort20209702145DOI Listing
January 2020

[Prostatic secretion microbiota: a comparative analysis of the hronical prostatitis II and IIIA category].

Urologiia 2020 Apr(2):16-22

Department of Urology and Human Reproductive Health, Rostov State Medical University, Rostov-on-Don, Russia.

Background: Chronic bacterial prostatitis (CBP) and chronic prostatitis/chronic pelvic pain syndrome IIIa (CP/CPPS IIIa) are separate nosologies defined diagnostic verification criteria according to the NIH-NIDDK classification (1995). The identification of enterobacteria in the prostatic secretion (PS) has long been a criterion for the diagnosis of CBP, while PS in patients suffering CP/CPPS IIIa was considered as "sterile". However, the introduction of various methods of PS`s in-depth analysis and UPOINTS classification (2010) development with the allocation of site I (infection) allows us to consider the infectious factor as an etiological predictor of the initiation of inflammation in the prostate with CP/CPPS IIIa. Read More

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[Colonization of group B streptococcus in the semen of chronic prostatitis patients of childbearing age and its influence on perinatal outcomes].

Zhonghua Nan Ke Xue 2019 Dec;25(12):1102-1105

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Objective: To investigate the colonization of group B streptococcus (GBS) in the semen of chronic prostatitis patients of childbearing age and its influence on perinatal outcomes.

Methods: This retrospective study included 592 cases of chronic prostatitis and another 472 non-prostatitis healthy males as controls. We collected semen samples from the subjects for bacterial and Ureaplasma urealyticum (UU) culture and quantitative fluorescence PCR analysis of chlamydia trachomatis (CT) and GBS. Read More

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December 2019

CHRONIC PROSTATITIS THERAPY COMBINED WITH ELECTROMYOSTIMULATION-ASPIRATION, TRANSURETHRAL ELECTROPHONOPHORESIS OF PLATELET-RICH PLASMA AND TRANSRECTAL LOW-INTENSITY PULSED ULTRASOUND.

Georgian Med News 2020 Feb(299):29-33

1"Man's Health" Clinic, Kiev, Ukraine.

Chronic inflammatory diseases of the prostate are one of the most common andurological nosology. This group of diseases includes heterogeneous pathology such as chronic bacterial prostatitis, chronic non-infectious prostatitis, prostate asymptomatic inflammation and chronic pelvic pain syndrome. Currently, biological and physiotherapeutic chronic prostate inflammatory diseases treatment methods are actively being studied, such as platelet rich plasma (PRP) therapy and low-intensity pulsed ultrasound (LIPUS) therapy. Read More

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February 2020

The Potential Protective Effect of Orange Peel and Selenium against 17β-Estradiol-Induced Chronic Non-Bacterial Prostatitis in Rats.

Anticancer Agents Med Chem 2020 Mar 30. Epub 2020 Mar 30.

Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo. Egypt.

Background: Prostate Cancer (PCa) is defined as a major health problem facing the male population.

Aims: We aimed to investigate the protective effects of Orange Peel Extract (OPE) and/or selenium (Se) on chronic non-bacterial prostatitis in a rat model.

Methods: Fifty-six adult male Wistar albino rats were castrated; after 5 days, they were divided randomly into eight groups (n= 7). Read More

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http://dx.doi.org/10.2174/1871520620666200331102609DOI Listing
March 2020
2.469 Impact Factor

[Efficiency assessment of low intensity-shokwave therapy in the treatment of chronic pelvic pain syndrome].

Urologiia 2020 Mar(1):46-50

European Medical Center, Moscow, Russia.

Objective: the aim of this study was to evaluate the effect of extracorporeal shockwave therapy on CPPS due to non bacterial prostatitis.

Method: s: There were two groups in the study. 78 patients in the first group received 6 sessions of Low intensity-shokwave therapy (Li-ESWT) in three weeks. Read More

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Screening for chronic prostatitis pathogens using high-throughput next-generation sequencing.

Prostate 2020 May 12;80(7):577-587. Epub 2020 Mar 12.

Department of Laboratory Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.

Background: The pathogens responsible for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS; NIH category III) are not currently known. the present study utilized high-throughput next-generation sequencing to screen for potential pathogens associated with NIH category III CP (CP III).

Methods: This study included 33 patients with CP III and 30 healthy men, from which one sample each of urethral secretions and expressed prostatic secretion (EPS) was collected. Read More

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http://dx.doi.org/10.1002/pros.23971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187444PMC

Fosfomycin trometamol and N-acetyl-L-cysteine as combined oral therapy of difficult-to-treat chronic bacterial prostatitis: Results of a pilot study.

Int J Antimicrob Agents 2020 Mar 8:105935. Epub 2020 Mar 8.

Department of Urology, Oslo University Hospital, Oslo, Norway and Institute of Clinical Medicine, University of Oslo, Norway and Institute of Clinical Medicine, University of Aarhus, Denmark.

This paper presents the results of a pilot study of difficult-to-treat patients (exhibiting several previous treatment failures or detection of extended-spectrum beta-lactamase [ESBL] strains) with chronic bacterial prostatitis (CBP) who underwent treatment with fosfomycin trometamol (FT) and N-acetyl-L-cysteine (NAC). Twenty-eight patients with clinically- and microbiologically-confirmed CBP who attended a single urological institution between January 2018 and March 2019 were treated with oral administration of 3 g FT once a day for 2 days, followed by a dose of 3 g every 48 h for 2 weeks, in combination with oral administration of NAC 600 mg once a day for 2 weeks. Clinical and microbiological analyses were carried out at the time of admission (T0) and during follow-up at 1 month (T1) and 6 months (T2) after the end of treatment. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.105935DOI Listing

Bacterial Biofilm and its Role in the Pathogenesis of Disease.

Antibiotics (Basel) 2020 Feb 3;9(2). Epub 2020 Feb 3.

Department of Food Safety and Animal Health Research, Norwegian Veterinary Institute, P.O. Box 750 Sentrum, N-0106 Oslo, Norway.

Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm infections are typically chronic in nature, as biofilm-residing bacteria can be resilient to both the immune system, antibiotics, and other treatments. This is a comprehensive review describing biofilm diseases in the auditory, the cardiovascular, the digestive, the integumentary, the reproductive, the respiratory, and the urinary system. Read More

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http://dx.doi.org/10.3390/antibiotics9020059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167820PMC
February 2020

[Improvement of performance of semen culture in infertile men undergone to diagnostic evaluation].

Urologiia 2019 12(6):26-30

Department of Surgical Diseases and Urology DPO of FGBOU VO Omsk State Medical University of the Ministry of Health of the Russian Federation, Omsk, Russia.

Introduction: Barren marriage is an important medical and social problem. Up to 20-60% of cases of male infertility are associated with inflammatory diseases of the reproductive system. Chronic prostatitis constitutes up to 50% cases. Read More

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December 2019

[Transrectal ozone and magnetic therapy for treatment of chronic bacterial prostatitis].

Urologiia 2019 12(6):6-11

GBU of Republic Dagestan City clinical hospital 1, Makhachkala, Russia.

Aim: To evaluate the efficiency of combined transrectal ozone and magnetic therapy for the treatment of chronic bacterial prostatitis (CBP).

Materials And Methods: A total of 142 men with CBP were included in the study and allocated to different treatment, including standard therapy for 6 weeks (n=40), transrectal magnetic therapy in addition to standard therapy (n=35), transrectal ozone therapy in addition to standard therapy (n=37), transrectal magnetic and ozone therapy in addition to standard therapy (n=30). Treatment results were evaluated 3 months after the completion of therapy. Read More

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December 2019

[NON-SPECIFIC GRANULOMATOUS PROSTATITIS: A CASE REPORT].

Nihon Hinyokika Gakkai Zasshi 2019 ;110(1):65-69

Department of Urology, Yokosuka-Kyosai Hospital.

We report non-specific granulomatous prostatitis in a 58-year-old man who visited a Urology clinic with fever and dysuria. Digital rectal examination revealed prostatic tenderness, and laboratory examination of the urinary sediment revealed pyuria. Thus, he was diagnosed with acute bacterial prostatitis and treated with antibiotics. Read More

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http://dx.doi.org/10.5980/jpnjurol.110.65DOI Listing
January 2019

Acute prostatitis after prostate biopsy under ciprofloxacin prophylaxis with or without ornidazole and pre-biopsy enema: analysis of 3.479 prostate biopsy cases.

Int Braz J Urol 2020 Jan-Feb;46(1):60-66

Department of Urology, Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medicine, NY, USA.

Objectives: To investigate the characteristics of cases of NIH category I acute prostatitis developed after transrectal prostate biopsy and clarifiy the risk factors and preventive factors.

Materials And Methods: We retrospectively reviewed the medical records of 3.479 cases of transrectal ultrasound-guided needle biopsies performed with different prophylactic antibiotherapy regimens at two different institutions between January 2011 and February 2016. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0257DOI Listing
February 2020

Comparison of antibiotic susceptibility of Escherichia coli between community-acquired and post-prostate biopsy acute bacterial prostatitis.

Arch Esp Urol 2019 Dec;72(10):1018-1025

Department of Urology. Dongguk University Ilsan Hospital. Gyeonggi-do. Republic of Korea.

Objectives: To compare the antibiotic susceptibility of Escherichia coli (E. coli) between community- acquired acute bacterial prostatitis (CA-ABP) and ABP following transrectal ultrasound-guided prostate biopsy (Bx-ABP).

Methods: A total of 4,383 patients underwent prostate biopsy from January 2005 to June 2014. Read More

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December 2019

Clinical pharmacokinetics of flomoxef in prostate tissue and dosing considerations for prostatitis based on site-specific pharmacodynamic target attainment.

J Infect Chemother 2020 Feb 9;26(2):236-241. Epub 2019 Dec 9.

Department of Clinical Pharmacotherapy, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Flomoxef is used to treat bacterial prostatitis; however, its prostatic pharmacokinetics have not been fully clarified. Flomoxef (500 or 1000 mg) was administered to patients with benign prostatic hypertrophy (n = 54). After a 0. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.08.019DOI Listing
February 2020

[The features of course of chronic abacterial prostatitis with inflammatory compoment in men of the first period of mature age depending on the somatotype. Part 2: laboratory and imaging characteristics].

Urologiia 2019 Dec(5):86-93

FGBOU VO Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky of the Ministry of Health of Russia, Krasnoyarsk, Russia.

Aim: to study the course of chronic abacterial prostatitis with the inflammatory component (CAPIC) depending on the somatotype in men of the first period of mature age taking complex treatment with a use of local and systemic ozone therapy.

Materials And Methods: A total of 306 men of asthenic, normostenic and pyknic somatotypes with CAPIC were followed-up. Along with standard therapy, all patients received systemic and local ozone therapy. Read More

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December 2019

[Experimental evaluation of inflammatory process in the prostate caused by transurethral transmission of uropathogen in low counts].

Urologiia 2019 Dec(5):14-21

Department of Urology and Human Reproductive Health with the course of Pediatric Urology-andrology of the Advanced Training and Specialist Professional Retraining Faculty FGBOU VO Rostov State Medical University of Russian Federation Ministry of Health, Rostov-on-Don, Russia.

Background: According to the literature, bacterial count of uropathogens isolated from expressed prostate secretion and urine which is sufficient for a diagnosis of bacterial prostatitis I and II categories, remains contradictory. Undoubtedly, the identification of microorganisms from affected organ in high titers indicates the presence of a relevant infectious-inflammatory process. In turn, there is no consensus on the development of bacterial prostatitis at lower titers of uropathogens. Read More

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December 2019

Efficacy and Safety of Two Fosfomycin Regimens as Antimicrobial Prophylaxis for Transrectal Prostate Biopsy: A Randomised Study.

Urol Int 2019 15;103(4):433-438. Epub 2019 Oct 15.

Department of Urology, Bolzano General Hospital, Bolzano, Italy.

Purpose: Prostate biopsy is the gold standard for prostate cancer diagnosis; unfortunately, this procedure is not free from complications. Recent studies have shown an increase in antibiotic resistance. The aim of our prospective randomized study was to evaluate the efficacy and safety of a prostate biopsy prophylaxis protocol using 2 vs. Read More

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http://dx.doi.org/10.1159/000502851DOI Listing
April 2020
2 Reads

Chronic prostatic infection: Microbiological findings in two Mediterranean populations.

Arch Ital Urol Androl 2019 Oct 2;91(3). Epub 2019 Oct 2.

Urology Department, Tzaneion Hospital, Piraeus.

Introduction/aim: Despite accumulated knowledge, several microbiological aspects of chronic bacterial prostatitis (CBP) remain uncertain. The aim of our study was to determine microbiological characteristics on our CBP population.

Materials: The material of this retrospective study consisted in bacterial isolates from urine and/or prostatic secretions or sperm cultures (total ejaculate) obtained from individuals with prostatitis symptoms and from patients with febrile relapses of CBP visiting our department, from 03/2009 to 03/2015. Read More

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http://dx.doi.org/10.4081/aiua.2019.3.177DOI Listing
October 2019
2 Reads

The role of fosfomycin for multidrug-resistant gram-negative infections.

Curr Opin Infect Dis 2019 12;32(6):617-625

Department of Health Sciences, University of Genoa, Genoa, Italy.

Purpose Of Review: In the last decade, an increasing interest in using fosfomycin for the treatment of multidrug-resistant gram-negative (MDR-GNB) infections have been registered, especially when none or only a few other active alternatives remained available.

Recent Findings: Fosfomycin may remain active against a considerable proportion of MDR-GNB. In observational studies, a possible curative effect of oral fosfomycin monotherapy has been described for uncomplicated urinary tract infections (UTI) and bacterial prostatitis caused by MDR-GNB, whereas intravenous fosfomycin has been mostly used in combination with other agents for various type of severe MDR-GNB infections. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000597DOI Listing
December 2019
14 Reads

Optimization of prostate brachytherapy techniques with polyethylene glycol-based hydrogel spacers: A systematic review.

Brachytherapy 2020 Jan - Feb;19(1):13-23. Epub 2019 Sep 18.

Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: The objective of this overview was to critically evaluate the effect of polyethylene glycol (PEG)-based hydrogel spacers during prostate brachytherapy with regard to dosimetric and clinical benefits, as well as procedure-related toxicity.

Methods And Materials: A systematic search in the PubMed database was performed.

Results: A total of 12 studies, involving 615 patients with PEG hydrogel injection, were included. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.08.009DOI Listing
September 2019
1 Read

The Use of a Combination of Vaccinium Macracarpon, Lycium barbarum L. and Probiotics (Bifiprost®) for the Prevention of Chronic Bacterial Prostatitis: A Double-Blind Randomized Study.

Urol Int 2019 17;103(4):423-426. Epub 2019 Sep 17.

Department of Urology, AORN A.Cardarelli, Naples, Italy.

Introduction: To evaluate the efficacy of Bifiprost® + Serenoa Repens 320 mg versus Serenoa Repens 320 mg alone for the prevention of chronic bacterial prostatitis (CBP) due to enterobacteriaceae.

Methods: Between September 2016 and September 2018, 120 patients with CBP at the National Institutes of Health (NIH type II) with recurrent infections due to enterobacteriaceae (Escherichia Coli and Enterococcus faecalis) were enrolled and randomized into 2 groups each to receive Bifiprost® + Serenoa Repens 320 mg (Group A) or Serenoa Repens 320 mg alone (Group B) daily for 24 weeks (after receiving a proper antibiotic treatment with subsequent culture negativization). The primary endpoint was the reduction in the episodes of prostatitis. Read More

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http://dx.doi.org/10.1159/000502765DOI Listing
April 2020
3 Reads
1.151 Impact Factor

Bacterial Endogenous Endophthalmitis in Bacteremic Inpatients.

Ophthalmol Retina 2019 11 20;3(11):971-978. Epub 2019 Jun 20.

Institute of Ophthalmology and Visual Science, Rutgers - New Jersey Medical School, Newark, New Jersey. Electronic address:

Purpose: Population-based reports regarding bacterial endogenous endophthalmitis (BEE) are scarce in the literature. Our study sought to investigate the incidence of BEE, relative risk of comorbid conditions, and treatment patterns using a nationally representative database, the National Inpatient Sample (NIS).

Design: Retrospective cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.oret.2019.06.004DOI Listing
November 2019
3 Reads

Xanthogranulomatous prostatitis presenting as prostatic abscesses: An uncommon complication after kidney transplantation.

IDCases 2019 10;17:e00559. Epub 2019 May 10.

Department of Medicine, Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada.

Xanthogranulomatous (XG) prostatitis is a rare form of granulomatous prostatitis characterized by a benign inflammatory process of non-specific etiology that clinically may mimic carcinoma. Few cases have been reported in the English language medical literature, with only four reported cases presenting as prostatic abscesses. A 70-year-old male with type 2 diabetes mellitus and two previous kidney transplants presented with septic shock secondary to bacteremia 4 days after undergoing a cystoscopy. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667697PMC
May 2019
8 Reads

[Use of cytomedins in case of prostatic involvement in chronic prostatitis according to UPOINT classification].

Urologiia 2019 Jul(3):31-35

Department of Urology and Andrology of A.I. Burnazyan SRC FMBC, FMBA of Russia, Moscow, Russia.

Background: chronic prostatitis is a common disease that significantly influence on the quality of life.

Aim: Our aim was to assess the prevalence of particular domains of UPOINT classification and determine the efficiency of prostate-selective cytomedins in complex therapy of chronic prostatitis with the predominance of organic component.

Materials And Methods: a total of 96 patients aged from 24 to 48 years were treated in City clinical hospital named after D. Read More

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July 2019
4 Reads

[Diagnosis and treatment of abacterial category III CP/CPPS, associated with herpes viruses].

Urologiia 2019 Jul(3):23-30

N.F. Gamaleya Research nter for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.

Introduction: The etiology of abacterial CP/CPPS (category III) has not been studied enough. Currently, there is no gold standard of diagnostic study and optimal treatment algorithm.

Aim: The aim of our study was to study three human herpes viruses (HHV) in clinical samples from patients with inflammatory diseases of urogenital tract and to evaluate the efficiency of proposed treatment algorithm for abacterial CP/CPPS. Read More

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July 2019
2 Reads

The effects of Cernitin® on inflammatory parameters and benign prostatic hyperplasia: An in vitro study.

Phytother Res 2019 Sep 25;33(9):2457-2464. Epub 2019 Jul 25.

Department of Translational Medicine, Lund University, Malmö, Sweden.

The pollen extract Cernitin® is widely used for treatment of benign prostatic hyperplasia (BPH) and non-bacterial chronin prostatitis. However, little is known about the underlying molecular mechanisms to explain the clinical effects of Cernitin®. In this study, we sought to investigate the cellular mechanisms by which Cernitin® induces its effects on human prostatic cell lines BPH-1 and WPMY-1 and primary human peripheral blood mononuclear cells (hPBMCs) in vitro. Read More

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http://dx.doi.org/10.1002/ptr.6438DOI Listing
September 2019
3 Reads

Repetitive urinary tract infections and two prostatic masses: Prostatic soft tissue infection with Actinomyces neuii.

Int J Infect Dis 2019 Sep 6;86:55-56. Epub 2019 Jul 6.

Department of Internal Medicine and Infectious Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands; Center for Infectious Disease Control, National Institute for Public Health and the Environment (Rijksinstituut voor Volksgezondheid en Milieu, RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address:

Actinomyces infection is a tissue destructive, low-grade infection that often resembles malignancy. We report the case of a 70-year-old male with repeated, culture-negative urinary tract infections while intermittently catheterized. At presentation, the patient reported a new episode of urinary tract infection with white discharge in his urine. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.06.029DOI Listing
September 2019
5 Reads

Rational use of the fluoroquinolones.

S Afr Med J 2019 May 31;109(6):378-381. Epub 2019 May 31.

Department of Critical Care, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

The systemic fluoroquinolones (FQs) have recently been reported to be associated with significant side-effects in susceptible individuals. This has prompted the Food and Drug Administration (FDA) in the USA and the European Medicines Agency (EMA) to issue warnings regarding their use. The FQs should not be used for common bacterial infections, such as urinary tract infections, travellers' diarrhoea and upper and lower respiratory tract infections, unless it is not possible to use another oral agent. Read More

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http://dx.doi.org/10.7196/SAMJ.2019.v109i6.14002DOI Listing
May 2019
4 Reads

Prostatic calcifications are associated with a more severe symptom burden in men with type II chronic bacterial prostatitis.

Arch Ital Urol Androl 2019 Jul 2;91(2). Epub 2019 Jul 2.

Tzaneio Hospital, Piraeus.

Introduction/aim: Although prostatic calculi/calcifications are encountered frequently in the urological practice, little is known about the incidence of such lesions, their mechanism of formation, their relationship to other prostate conditions and their clinical significance. The purpose of this study is to describe the characteristics and to investigate the clinical significance of prostatic calcifications (PCs) in patients with chronic bacterial prostatitis (CBP).

Materials And Methods: This study was conducted between 01/02/2013 and 20/02/2018. Read More

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http://dx.doi.org/10.4081/aiua.2019.2.79DOI Listing
July 2019
2 Reads

Chronic prostatitis/pelvic pain syndrome: MRI findings and clinical correlations.

Andrologia 2019 Oct 2;51(9):e13361. Epub 2019 Jul 2.

Radiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

We aimed to evaluate whether pelvic magnetic resonance imaging (MRI) could play a role in better assessing chronic pelvic pain syndrome. We evaluated 44 male patients (median 41 aged) with a clinical history of painful pelvic symptoms, lasting for at least three of the previous 6 months, associated with urinary, anorectal and sexual disorders in the absence of bacterial prostate infection. All these patients underwent ultrasound (US) and MRI evaluation of the pelvis. Read More

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http://dx.doi.org/10.1111/and.13361DOI Listing
October 2019
6 Reads

Chronic prostatitis: current treatment options.

Res Rep Urol 2019 4;11:165-174. Epub 2019 Jun 4.

Department of Urology, Usl Toscana Sud Est, San Donato Hospital, Arezzo, Italy.

Male chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is represented by a heterogeneous group of symptoms that can cause an important impairment of daily quality of life for patients. Diagnosis of CP/CPPS is often not clear and treatment can be challenging, as it varies according to the different causative factors and derived symptoms. Differently from approaches used in the past, the diagnosis and subsequent treatment rely on separating this entity from chronic bacterial prostatitis and considering it as a multifactorial disease. Read More

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http://dx.doi.org/10.2147/RRU.S194679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556531PMC
June 2019
11 Reads

[A comparative analysis of the effectiveness of serenoa repens and serenoa repens in combination with urtica dioiccus for lower urinary symptoms suggestive of benign prostatic hyperplasia associated with chronic inflammation in prostate tissue].

Urologiia 2019 Apr(1):40-46

Department of urology and reproductive health with the course of pediatric urology and andrology of FGBOU VO Rostov State Medical University of the Minzdrav of Russia, Rostov-on-Don, Russia.

Introduction: Benign prostatic hyperplasia (BPH) is the most common proliferative disease of the prostate gland in the elderly.

Materials And Methods: The results of an open, randomized comparative study of the effectiveness of Serenoa repens in the combination with Urtica dioiccus (Prostagut-forte) are presented in the article. All patients were divided into two groups, depending on the therapy. Read More

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April 2019
5 Reads

[Justification of a use of additional antioxidant therapy in experimental models of chronic bacterial prostatitis].

Urologiia 2019 Apr(1):16-22

) Kursk State Medical University, Kursk, Russia.

Aim: To study the changes of the main parameters of the oxidative status in prostate after standard antimicrobial monotherapy and to justify a use of additional antioxidant therapy in various experimental models of chronic bacterial prostatitis (CBP).

Material And Methods: A total of 60 outbred adult male healthy rats weighing 180-200 grams were used in the experiment. In a control group, 20 intact rats were included. Read More

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April 2019
5 Reads

Inhibition of p53 alleviates prostate cell apoptosis in Escherichia coli‑induced bacterial prostatitis.

Authors:
Hai Wang Zhigang Ji

Mol Med Rep 2019 Aug 6;20(2):895-902. Epub 2019 Jun 6.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, P.R. China.

Previous studies demonstrated that uropathogenic Escherichia coli infection contributes to human bacterial prostatitis. Apoptosis of prostate epithelial cells is closely associated with the progression of bacterial prostatitis. The aim of the present study was to investigate the effect of cellular tumor antigen p53 (p53) on the apoptosis of bacterial prostatitis cells. Read More

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http://dx.doi.org/10.3892/mmr.2019.10354DOI Listing
August 2019
4 Reads

The role of prostaglandin and E series prostaglandin receptor type 4 receptors in the development of bladder overactivity in a rat model of chemically induced prostatic inflammation.

BJU Int 2019 11 26;124(5):883-891. Epub 2019 Jun 26.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Objectives: To evaluate, using a rat model of non-bacterial prostatic inflammation, the prostaglandin production and expression profiles of E-series prostaglandin (EP) receptor subtypes, which are reportedly implicated in the development of overactive bladder, in the bladder mucosa, and to investigate the effect of EP receptor type 4 (EP4) blockade on bladder overactivity after prostatic inflammation.

Methods: Male Sprague-Dawley rats were used. Prostatic inflammation was induced by formalin injection (5%; 50 μL per lobe) into the bilateral ventral lobes of the prostate. Read More

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http://dx.doi.org/10.1111/bju.14845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327235PMC
November 2019
22 Reads

Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase.

Oncogene 2019 07 31;38(28):5580-5598. Epub 2019 May 31.

Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Gram-negative bacteria have been found to be a major population in prostatitis and prostate cancer (PCa) tissues. Lipopolysaccharide (LPS), a major compound of Gram-negative bacteria, with stimulatory activities in some cancer types, but has not been fully studied in PCa. In this study, we examined the effect of LPS on the invasion of PCa cells. Read More

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http://dx.doi.org/10.1038/s41388-019-0833-3DOI Listing
July 2019
6 Reads

The Effect of Flavonoids on Chronic Prostatitis: A Meta-analysis of Published Randomized Controlled Trials.

J Natl Med Assoc 2019 Oct 23;111(5):555-562. Epub 2019 May 23.

School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012, PR China. Electronic address:

Objective: To assess the effect of flavonoids on chronic prostatitis, a meta-analysis of randomized controlled trials was performed.

Methods: Through using subject word and random word, PubMed, Scopus, Web of Science, and Cochrane Library were searched for related records up to July 2018. The response rate and National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) were used to evaluate the therapeutic efficacy of the flavonoids. Read More

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http://dx.doi.org/10.1016/j.jnma.2019.04.007DOI Listing
October 2019
7 Reads

White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED.

Eur J Clin Microbiol Infect Dis 2019 Aug 22;38(8):1523-1532. Epub 2019 May 22.

Emergency Department, Hautepierre Hospital, University Hospital of Strasbourg, 1 Avenue Molière, 67200, Strasbourg, France.

Identifying an infection may be difficult in the ED. Neutrophilic leukocytosis is often used in the diagnosis of infection despite its lack of specificity in situations of stress. Our objective was to study the value of each parameter of the WBC count, in particular eosinopenia, to diagnose bacterial infections in the ED. Read More

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http://dx.doi.org/10.1007/s10096-019-03583-2DOI Listing
August 2019
9 Reads

Levofloxacin for NIH Category II Chronic Bacterial Prostatitis: A Real-Life Study.

Chemotherapy 2019 21;64(1):8-16. Epub 2019 May 21.

Department of Urology, University of Milan-Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.

Background: Mounting worldwide resistance trends make the use of fluoroquinolone (FQ) antibacterial agents increasingly difficult. This is felt more acutely in the case of urogenital infections, which are mainly caused by Gram-negative pathogens. For years, levofloxacin and other FQs have been the first-line drugs for treating National Institutes of Health (NIH) category II chronic bacteria prostatitis (CBP). Read More

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https://www.karger.com/Article/FullText/499034
Publisher Site
http://dx.doi.org/10.1159/000499034DOI Listing
July 2019
22 Reads
1.554 Impact Factor

FDG PET/CT in a Case of Bilateral Tuberculous Epididymo-orchitis.

Clin Nucl Med 2019 Sep;44(9):757-760

Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.

Isolated genital tuberculosis is rare. We present a case of bilateral tuberculous epididymo-orchitis showing high FDG uptake on FDG PET/CT. In addition, the patient had a prostatic FDG-avid lesion, consistent with tuberculous prostatitis. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002606DOI Listing
September 2019
10 Reads

Chronic prostatitis alters the prostatic microenvironment and accelerates preneoplastic lesions in C57BL/6 mice.

Biol Res 2019 May 14;52(1):30. Epub 2019 May 14.

Life Sciences Institute, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Background: Chronic prostatitis has been supposed to be associated with preneoplastic lesions and cancer development. The objective of this study was to examine how chronic inflammation results in a prostatic microenvironment and gene mutation in C57BL/6 mice.

Methods: Immune and bacterial prostatitis mouse models were created through abdominal subcutaneous injection of rat prostate extract protein immunization (EAP group) or transurethral instillation of uropathogenic E. Read More

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http://dx.doi.org/10.1186/s40659-019-0237-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518623PMC
May 2019
9 Reads

Co-culture of Methanobrevibacter smithii with enterobacteria during urinary infection.

EBioMedicine 2019 May 7;43:333-337. Epub 2019 May 7.

Laboratoire de bactériologie, Centre Hospitalier Universitaire de Nice, Hôpital de l'Archet II, Nice, France; Université Côte d'Azur, Inserm, C3M, Nice, France; Inserm U1065, C3M, Equipe 6 « Virulence microbienne et signalisation inflammatoire », Bâtiment universitaire Archimède, Nice, France. Electronic address:

Background: Urinary tract infections are known to be caused by bacteria, but the potential implications of archaea have never been studied in this context.

Methods: In two different university hospital centres we used specific laboratory methods for the detection and culture of archaeal methanogens in 383 urine specimens prospectively collected for diagnosing urinary tract infection (UTI).

Findings: Methanobrevibacter smithii was detected by quantitative PCR and sequencing in 34 (9%) of the specimens collected from 34 patients. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558020PMC
May 2019
27 Reads