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Andrologia 2020 May 26:e13637. Epub 2020 May 26.

Obstetrics Service/Assisted Human Reproduction Unit, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Spain.

The objective was to explore presence/detection of microorganisms in the male reproductive tract (PMMRT) in asymptomatic patients undergoing infertility treatment and their effects on semen quality in our region. This study enrolled 205 men (mean age, 35.9 years) in a single-centre, tertiary university hospital from December 2015 to December 2016. Read More

Medicina (B Aires) 2020 ;80(3):241-247

Sociedad Argentina de Infectología, Argentina.

The second part of the Inter-Society Argentine Consensus on Urinary Tract Infection (UTI) includes the analysis of special situations. In patients with urinary catheter, urine culture should be requested only in the presence of UTI symptomatology, before instrumentation of the urinary tract, or as a post-transplant control. The antibiotics recommended for empirical treatment in patients without risk factors are third-generation cephalosporins or aminoglycosides. Read More

Medicina (B Aires) 2020 ;80(3):229-240

Sociedad Argentina de Infectología, Argentina.

The Argentine Society of Infectious Diseases and other scientific societies have updated these recommendations based on data on urinary tract infections in adults obtained from a prospective multicenter study conducted in Argentina during 2016-2017. Asymptomatic bacteriuria should be treated only in pregnant women, who should also be systematically investigated; the antibiotics of choice are nitrofurantoin, amoxicillin, clavulanic/amoxicillin, cephalexin and trimethoprim-sulfamethoxazole. In procedures involving injury to the urinary tract with bleeding, it is recommended to request urine culture and, in the presence of bacteriuria, antimicrobial treatment according to sensitivity should be prescribed from immediately before up to 24 hours after the intervention. Read More

BJU Int 2020 May 21. Epub 2020 May 21.

Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Objectives: To assess the presence of self-reactive immune responses to seminal and prostate antigens (PAg), biomarkers of inflammation of the male genital tract and semen quality parameters in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Subjects And Methods: peripheral blood and semen samples were collected from CP/CPPS patients and age-matched healthy control volunteers. The analysis of lymphoproliferative responses of peripheral blood mononuclear cells (PBMC) to different seminal plasma-derived and purified PAg, serum autoantibodies specific to PAg, leukocyte subpopulations and inflammatory cytokines in semen, sperm apoptosis/necrosis, and semen quality parameters were performed. Read More

Kaohsiung J Med Sci 2020 May 21. Epub 2020 May 21.

Department of Urology, Affiliated Hangzhou First People's Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou, China.

To explore the mechanism of microRNA-155 (miR-155) deficiency, protecting against experimental autoimmune prostatitis (EAP) in a toll-like receptor 4 (TLR4)-dependent manner. After wild-type (WT) and miR-155 mice were injected with complete Freund's adjuvant and prostate antigen to establish EAP model, half were randomly selected for injection with lipopolysaccharide (LPS, a TLR4 ligand). The following experiments were then performed: von Frey filaments, hematoxylin-eosin (HE) staining, real time quantitative polymerase chain reaction (qRT-PCR), Western blotting, and enzyme-linked immunosorbent assay (ELISA). Read More

Res Nurs Health 2020 May 20. Epub 2020 May 20.

School of Nursing and Midwifery, Robert Gordon University, Aberdeen, Scotland.

Front Pharmacol 2020 30;11:589. Epub 2020 Apr 30.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Objective: Identifying biomarkers of prostatic inflammation has been a question of great interest in the development of anti-inflammatory pharmacotherapy for lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH). Systemic inflammation and serum prostate-specific antigen (PSA) have been linked with prostatic inflammation. This study set out to develop a diagnostic model for prostatic inflammation using clinical and laboratory parameters. Read More

Front Pharmacol 2020 30;11:504. Epub 2020 Apr 30.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Prostatitis is a common urinary tract condition but bring innumerable trouble to clinicians in treatment, as well as great financial burden to patients and the society. Bacterial prostatitis (acute bacterial prostatitis plus chronic bacterial prostatitis) accounting for approximately 20% among all prostatitis have made the urological clinics complain about the genital and urinary systems all over the world. The international challenges of antibacterial treatment (emergence of multidrug-resistant bacteria, extended-spectrum beta-lactamase-producing bacteria, bacterial biofilms production and the shift in bacterial etiology) and the transformation of therapeutic strategy for classic therapy have attracted worldwide attention. Read More

Transl Androl Urol 2020 Apr;9(2):485-493

Department of Andrology, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai 519015, China.

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a chronic disease with a variety of psychosocial and somatic symptoms. CP/CPPS has substantial health care costs with unclear etiology, which may be caused by psychosocial factors. Moreover, previous studies suggested that cognitive processes played a crucial role in the perception of somatic pain. Read More

Transl Androl Urol 2020 Apr;9(2):398-404

Department of Urology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Although empirical antibacterial treatments are currently recommended for inflammatory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), physicians cannot verify infections in most cases. Therefore, in this study, the microbiota of semen was investigated via pyrosequencing to obtain evidence underlying infectious disease.

Methods: Patients diagnosed with CP/CPPS (n=17) and healthy volunteers (n=4) participated in the study. Read More

Transl Androl Urol 2020 Apr;9(2):391-397

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Chronic prostatitis/chronic pelvic pain syndrome type III (CP/CPPS) is associated with pelvic pain, sexual dysfunction and irritative voiding. Sustained symptom relief has proven difficult with alpha blockers, antibiotics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Phosphodiesterase type 5 (PDE5) inhibitors (PDE5is) have the potential to alleviate bladder urgency, relax the pelvic floor, and correct underlying erectile dysfunction; however, few studies have investigated the application of PDE5i's to CP/CPPS. Read More

Turk J Urol 2020 05 29;46(3):213-218. Epub 2019 Nov 29.

Turkish Urology Academy, Study Group of Prostate Biopsy: Ateş Kadıoğlu, Asıf Yıldırım, Sakıp Erturhan, Akif Erbin.

Objective: Antibiotic prophylaxis for transrectal prostate biopsy (PB) is very important in preventing infectious complications, and in this study, we aimed to evaluate the antibiotic preferences of Turkish urologist for transrectal PB.

Material And Methods: The survey about PB and antibiotic prophylaxis behaviors was administered to urologists working in Turkey who had previously participated in at least one international and one national congress.

Results: A total of 237 urologists were included in the study. Read More

Andrologia 2020 May 12:e13617. Epub 2020 May 12.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Obesity is considered a global health problem affecting more than a third of the population. Complications of obesity include cardiovascular diseases, type 2 diabetes mellitus, malignancy (including prostatic cancer), neurodegeneration and accelerated ageing. In males, these further include erectile dysfunction, poor semen quality and subclinical prostatitis. Read More

Urol Case Rep 2020 Sep 28;32:101231. Epub 2020 Apr 28.

Urology Department, King Fahad Medical City, Saudi Arabia.

Prostatic abscess is declining disease because of widespread using of antibiotic in management of early prostatitis and urinary tract infections. Causing pathogenic factors usually gram-negative organisms. In lack of a guidelines, diagnosis and management sometimes is a challenge. Read More

Clin Genitourin Cancer 2020 Apr 14. Epub 2020 Apr 14.

Urology Unit, Cannizzaro Hospital, Catania, Italy.

Introduction: The purpose of this study was to evaluate the biopsy histology of men who underwent transperineal multi-parametric magnetic resonance imaging (mpMRI)/transrectal ultrasound fusion biopsy for Prostate Imaging Reporting and Data System (PI-RADS) score 5 lesions.

Patients And Methods: From January 2016 to June 2019, 105 men with PI-RADS score 5 underwent mpMRI/transrectal ultrasound fusion biopsy combined with systematic prostate biopsy. All the patients underwent a 3. Read More

Urology 2020 May 4. Epub 2020 May 4.

Department of urology, JIPMER, Puducherry, India.

Emphysematous prostatitis is a rare, clinical condition characterized by gas and abscess formation in the prostate often associated with features of sepsis. We report a case of 60-year-old gentleman presenting with emphysematous prostatitis complicated with secondary psoas abscess and florid sepsis following prostate biopsy. Read More

Curr Pain Headache Rep 2020 May 6;24(6):27. Epub 2020 May 6.

Department of Anesthesiology, Creighton University School of Medicine, Omaha, NE, USA.

Purpose Of Review: Urologic chronic pelvic pain syndrome (UCPPS) is a chronic, noncyclic pain condition which can lead to significant patient morbidity and disability. It is defined by pain in the pelvic region, lasting for greater than 3 to 6 months, with no readily identifiable disease process. The aim of this review is to provide a comprehensive update of diagnosis and treatment of UCPPS. Read More

Vopr Kurortol Fizioter Lech Fiz Kult 2020 ;97(2):45-51

Ural State Medical University, Ekaterinburg, Russia.

Introduction: Lower urinary tract symptoms (LUTS) caused by chronic prostatitis (CP) are a common condition. Standard antibiotic therapy is often not justified, since bacterial prostatitis is presented in up to 10% of the cases, while there is no effect on the risk factors for the development and relapse of the disease. This study is aimed at one of the main risk factors for LUTS - a sedentary lifestyle. Read More

Andrologia 2020 Apr 30:e13607. Epub 2020 Apr 30.

Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, South Korea.

We investigated the correlation between the presence of leucocytes in expressed prostatic secretion and the lower urinary tract symptom severity by retrospectively reviewing 699 men with lower urinary tract symptoms. The patients were evaluated by the International Prostate Symptoms Score and the Overactive Bladder Symptoms Score and underwent expressed prostatic secretion testing. Patients were classified into groups 1 and 2 based on the expressed prostatic secretion leucocyte count. Read More

Urologiia 2020 Apr(2):16-22

Department of Urology and Human Reproductive Health, Rostov State Medical University, Rostov-on-Don, Russia.

Background: Chronic bacterial prostatitis (CBP) and chronic prostatitis/chronic pelvic pain syndrome IIIa (CP/CPPS IIIa) are separate nosologies defined diagnostic verification criteria according to the NIH-NIDDK classification (1995). The identification of enterobacteria in the prostatic secretion (PS) has long been a criterion for the diagnosis of CBP, while PS in patients suffering CP/CPPS IIIa was considered as "sterile". However, the introduction of various methods of PS`s in-depth analysis and UPOINTS classification (2010) development with the allocation of site I (infection) allows us to consider the infectious factor as an etiological predictor of the initiation of inflammation in the prostate with CP/CPPS IIIa. Read More

BMC Complement Med Ther 2020 Apr 28;20(1):128. Epub 2020 Apr 28.

Department of Sociology, National University of Singapore, AS1 04-30, 11 Arts Link, Singapore, 117570, Singapore.

Background: Traditional medicine is broadly used across Asian societies for various medical conditions and health concerns. However, there remains a wide disparity between users and non-use, which makes it imperative to understand the factors affecting the lay perception and utilization of traditional medicine. This study systematically examined the demographic, medical, and socioeconomic factors affecting belief in and use of traditional medicine among older adults of Shanghai, China. Read More

Cureus 2020 Mar 25;12(3):e7417. Epub 2020 Mar 25.

Family Medicine, Southern Illinois University School of Medicine, Springfield, USA.

Blastomycosis is an uncommon disease caused by the dimorphic fungus, Blastomyces dermatitidis, often found in endemic regions of Midwestern America. It can be found in forested, sandy soils, decaying vegetation, rotting wood near water sources, and even in bird feces. Most commonly, blastomycosis manifests as a pulmonary infection presenting as pneumonia, or in severe cases, respiratory distress syndrome (ARDS). Read More

J Urol 2020 Apr 14:101097JU0000000000001080. Epub 2020 Apr 14.

Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Purpose: To evaluate and identify baseline factors associated with change in health-related quality of life (HRQOL) among patients with interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods: A total of 191 men and 233 women with IC/BPS or CP/CPPS (collectively referred to as urologic chronic pelvic pain syndrome, or UCPPS) were followed for 12 months with bimonthly completion of the Short Form 12 (SF-12) to assess general mental and physical HRQOL, and with biweekly assessment of condition-specific HRQOL using the Genitourinary Pain Index. A functional clustering algorithm was used to classify participants as improved, stable, or worsened for each HRQOL measure. Read More

Urol Case Rep 2020 Jul 3;31:101154. Epub 2020 Apr 3.

Division of Urology, Department of Surgery, Tungs' Taichung MetroHarbor Hospital, No. 699, Sec. 8, Taiwan Blvd., Wuqi Dist., Taichung City, 43503, Taiwan.

Xanthogranulomatous prostatitis is a rare occasion that mimics the prostate cancer in every aspect of clinical diagnosis. These two occasions require totally diverse therapeutics principles. Thus, emphasis should be exerted to distinguish them. Read More

J Urol 2020 05 10;203(5):862. Epub 2020 Feb 10.

Pain Res Manag 2020 9;2020:5921038. Epub 2020 Mar 9.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

This study aimed to evaluate the efficacy and safety of acupuncture for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). A search of PUBMED, EMBASE, Central Register of Controlled Trials (CENTRAL), Web of Science, Chinese Biomedicine Literature (CBM), China National Knowledge Infrastructure (CNKI), Wang-Fang Database, Chinese Scientific Journal Database (VIP), and other available resources was made for studies (up to February 2019). Searches were limited to studies published in English and Chinese. Read More

Pain Res Manag 2020 19;2020:3967414. Epub 2020 Mar 19.

Department of Propedeutics, Physical Diagnostics and Dental Physiotherapy, Pomeranian Medical University in Szczecin, Szczecin, Poland.

. Lower back pain (LBP) is almost a problem of civilizations. Quite often, it is a consequence of many years of disturbed distribution of tension within the human body caused by local conditions (injuries, hernias, stenoses, spondylolisthesis, cancer, etc. Read More

Prostate 2020 Jun 7;80(9):663-673. Epub 2020 Apr 7.

Department of Urology, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China.

Background: Depressive symptoms are found in approximately 78% of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) patients, but the pathological mechanisms remain unknown. Increasing evidence suggests that abnormal gut microbiota may play an important role in depression. Thus, we aimed to investigate whether gut microbiota contributes to CP/CPPS-associated depression by using a mouse model of experimental autoimmune prostatitis (EAP). Read More

Arch Ital Urol Androl 2020 Apr 6;92(1):1-6. Epub 2020 Apr 6.

University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Department of Urology, Bursa.

Objective: In the management of benign prostatic hyperplasia (BPH), urology guide- lines recommend medical or surgical treatments according to different prostate volumes (PV). The aim of this study was to analyze the relationships between PV and age, total and free prostate specific antigen (tPSA, fPSA) and fPSA/tPSA ratio in patients without histologically proven prostate cancer.

Materials And Methods: A retrospective analysis was made of the data of 1334 patients who underwent transrectal ultra- sound (TRUS)-guided prostate biopsy between January 2016 and October 2018. Read More

Zhonghua Nan Ke Xue 2019 Dec;25(12):1102-1105

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Objective: To investigate the colonization of group B streptococcus (GBS) in the semen of chronic prostatitis patients of childbearing age and its influence on perinatal outcomes.

Methods: This retrospective study included 592 cases of chronic prostatitis and another 472 non-prostatitis healthy males as controls. We collected semen samples from the subjects for bacterial and Ureaplasma urealyticum (UU) culture and quantitative fluorescence PCR analysis of chlamydia trachomatis (CT) and GBS. Read More

BJU Int 2020 Apr;125(4):479-480

Urology, Queen's University, Kingston, ON, Canada.

Georgian Med News 2020 Feb(299):29-33

1"Man's Health" Clinic, Kiev, Ukraine.

Chronic inflammatory diseases of the prostate are one of the most common andurological nosology. This group of diseases includes heterogeneous pathology such as chronic bacterial prostatitis, chronic non-infectious prostatitis, prostate asymptomatic inflammation and chronic pelvic pain syndrome. Currently, biological and physiotherapeutic chronic prostate inflammatory diseases treatment methods are actively being studied, such as platelet rich plasma (PRP) therapy and low-intensity pulsed ultrasound (LIPUS) therapy. Read More

Chin J Integr Med 2020 Apr 1. Epub 2020 Apr 1.

School of Acupuncture-Moxbustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Objective: To evaluate the effectiveness and safety of Chinese herbal external umbilicus treatment with Modified Dinggui Powder (, MDGP) in patients with chronic nonbacterial prostatitis (CNP).

Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted among 72 patients with CNP. Participants were randomly allocated to a treatment group and a placebo group using computer software in a 1:1 ratio, and received either MDGP external umbilicus treatment (MDGP group, 36 cases) or placebo control groupl (36 cases) at acupoints Shenque (CV 8), twice a week for 4 weeks. Read More

Sex Med Rev 2020 Mar 29. Epub 2020 Mar 29.

Physio Works Muskoka, Huntsville, ON, Canada.

Introduction: Overactive pelvic floor (OPF) muscles are defined as muscles that do not relax, or may even contract, when relaxation is needed, for example, during micturition or defecation. Conditions associated with OPF are multifactorial and include multiple possible etiologies and symptom complexes. The complex interplay between biological and psychosocial elements can lead to the persistence of OPF symptoms along with psychological and emotional distress. Read More

Zhonghua Nan Ke Xue 2019 Oct;25(10):914-922

Department of Urology, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.

Objective: To systematically evaluate the clinical efficacy of the extracorporeal shock wave therapy (ESWT) in the treatment of chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS) and provide some evidence for the management of the disease.

Methods: We searched the PubMed, Cochrane Library, EMbase, CNKI, VIP, WanFang Data and CBM databases on the internet, as well as the Journal of Clinical Urology and Chinese Journal of Urology manually for randomized controlled trials (RCT) on the treatment of CP/CPPS by ESWT published from their establishment till February 1, 2019. Two reviewers independently screened the literature, extracted the data and assessed the risk of bias of the included studies, followed by a meta-analysis with the RevMan 5. Read More

Anticancer Agents Med Chem 2020 Mar 30. Epub 2020 Mar 30.

Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo. Egypt.

Background: Prostate Cancer (PCa) is defined as a major health problem facing the male population.

Aims: We aimed to investigate the protective effects of Orange Peel Extract (OPE) and/or selenium (Se) on chronic non-bacterial prostatitis in a rat model.

Methods: Fifty-six adult male Wistar albino rats were castrated; after 5 days, they were divided randomly into eight groups (n= 7). Read More

Zhonghua Nan Ke Xue 2019 Jul;25(7):626-631

Department of Urology, South Campus, Renji Hospital, Shanghai Jiao tong University School of Medicine, Shanghai 201112, China.

Objective: To investigate the clinical therapeutic effects of sacral nerve magnetic stimulation (SNMS) combined with extracorporeal shockwave (ECSW) in the treatment of type-ⅢB chronic prostatitis.

Methods: This study included 65 cases of type-ⅢB chronic prostatitis treated in Renji Hospital between March 2017 and August 2018. The patients were aged 34. Read More

Zhonghua Nan Ke Xue 2019 Jun;25(6):504-508

Department of Urology / Peking University Research Institute of Urology / National Urological Cancer Center, Peking University First Hospital, Beijing 100034, China.

Objective: To investigate the association of the grades of histologic prostatic inflammation (HPI) with prostate cancer in biopsy specimens for male patients with total serum PSA (tPSA) of 4－10 μg/L.

Methods: We performed prostate biopsy for 200 patients with tPSA of 4－10 μg/L from January 2015 to December 2017. We determined the location, extent and intensity of HPI and analyzed the correlation of the grades of HPI with the risk of prostate cancer. Read More

Zhonghua Nan Ke Xue 2019 Jun;25(6):500-503

Department of Andrology, Nanjing School of Clinical Medicine, Southern Medical University / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.

Objective: To study the relationship of the content of prostatic exosomal protein (PSEP) in the urine with the counts of WBCs and small particles of lecithin (SPL) in the EPS and NIH-CPSI in patients with chronic prostatitis.

Methods: We collected mid-stream urine samples from 367 chronic prostatitis patients in the Department of Andrology of the General Hospital of Eastern Theater Command from November 2017 to August 2018. We measured the content of PSEP in the urine, counted WBCs and SPLs in the EPS of the patients, obtained their NIH-CPSI scores, and analyzed the correlation of the PSEP level with the WBC and SPL counts and NIH-CPSI scores of the patients. Read More

Zhonghua Nan Ke Xue 2019 Jun;25(6):496-499

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.

Objective: To investigate the correlation of the six phenotypic domains of the UPOINT (urinary, psychosocial, organ-specific, infection, neurologic/systemic, and tenderness) system with premature ejaculation (PE) and ED in male patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods: We collected the clinical data on 453 cases of CP/CPPS from December 2016 to December 2017, including the general information, CP symptoms, sexual life history, intravaginal ejaculatory latency time (IELT), NIH-CPSI, and IIEF-5 scores. We classified the patients according to the UPOINT system. Read More

Zhonghua Nan Ke Xue 2019 Jun;25(6):489-495

Faculty of Basic Sciences, School of Medicine, Pingdingshan College, Pingdingshan, Henan 467000, China.

Objective: To investigate the correlation between the behavioral performance and the expressions of substance P (SP) and neurokinin-1 receptor (NK-1R) in the posterior horn of the L5－S2 spinal cord in rats with chronic prostatitis (CP).

Methods: A CP model was made in 30 adult male SD rats by intraperitoneal injection of 0.5 ml dyphtheria pertussis tetanus (DPT) vaccine and mixed solution of 1 ml prostatein extract and complete adjuvant in a 1∶1 ratio, and another 10 rats were injected with the same volume of normal saline as controls. Read More

Microorganisms 2020 Mar 25;8(4). Epub 2020 Mar 25.

Department of Medicine and Health Sciences "Vincenzo Tiberio", Università degli Studi del Molise-III Ed Polifunzionale, 86100 Campobasso, Italy.

is a well-known opportunistic uropathogen that can occur with cystitis, pyelonephritis, and urinary sepsis. Although a wide variety of coryneform bacteria have been found from the male genital tract of prostatitis patients, only one clinical case of prostatitis caused by has been reported. The aim of this study was to evaluate the tropism of towards LNCaP (lymph node carcinoma of the prostate) human cells line and the influence of acetohydroxamic acid as an irreversible urease inhibitor on different aspects of its pathogenicity by means of several tests, such as the determination and analysis of growth curves, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the production of biofilms, and adhesion to LNCaP and HeLa cell lines. Read More

Microbiol Resour Announc 2020 Mar 26;9(13). Epub 2020 Mar 26.

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA

This is an announcement for the genome sequence of a clinical isolate of subsp. isolated from the urine and prostate of a 6-year-old male Labrador retriever. This is one of the few reports of a subsp. Read More

Zhonghua Nan Ke Xue 2019 May;25(5):444-450

School of Management, Beijing University of Chinese Medicine, Beijing 100029, China.

Objective: To comprehensively evaluate the clinical effect, safety and cost of Qianlieshutong Capsules (QC) in the treatment of chronic prostatitis.

Methods: We searched Cochrane Library, PubMed, Springer, ProQuest, CNKI, Wanfang Data and VIP for randomized controlled trials (RCT) on the treatment of chorionic prostatitis with QC published from January 2000 to May 2018. According to the inclusion and exclusion criteria, two researchers independently completed the screening and evaluation of the articles, extraction of information, and meta-analysis of the included RCTs using the RevMan 5. Read More

Zhonghua Nan Ke Xue 2019 May;25(5):420-423

Department of Urology, Shenzhen Second People's Hospital / The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518035, China.

Objective: To investigate the necessity of medication for patients with type Ⅲ prostatitis-like symptoms for less than 3 months.

Methods: We enrolled in this study 171 outpatients with type Ⅲ prostatitis-like symptoms for less than 3 months in our hospital from November 2016 to October 2017, and randomly divided them into groups A (n = 57), B (n = 57) and C (n = 57). The patients of group A received tamsulosin, levofloxacin and health education, those of group B tamsulosin and health education, and those of group C health education only. Read More

Zhonghua Nan Ke Xue 2019 May;25(5):399-402

Department of Andrology, Nanjing School of Clinical Medicine, Southern Medical University / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.

Objective: To investigate the effect of saw palmetto extract (SPE) on the reproductive function of rats with chronic prostatitis (CP).

Methods: Forty male SD rats were equally randomized into groups A (blank control), B (blank control + SPE, C (CP model control) and D (CP model + SPE), and the CP model was made by injection of 1% λ-carrageenan solution into the prostate. The animals in groups A and C were gavaged with normal saline while those in groups B and D with SPE at 0. Read More

Cureus 2020 Feb 19;12(2):e7046. Epub 2020 Feb 19.

Internal Medicine, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

Gram-negative bacilli are usually implicated in the formation of prostatic abscesses (PA) which is a rare complication of prostatitis. However, PA methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a substantial cause of PA in recent years. Predisposing factors for MRSA prostatitis include immunocompromised states such as human immunodeficiency virus (HIV), uncontrolled diabetes, intravenous drug use (IVDU), urethral instrumentation, bladder outlet obstruction, preexisting prostatic disease, recent prostatic procedure, and chronic dialysis among others. Read More

World J Mens Health 2020 Feb 5. Epub 2020 Feb 5.

Department of Urology, Urological Cancer Center, National Cancer Center, Goyang, Korea.

Purpose: We evaluated the impact of benign prostatic hyperplasia (BPH) and prostatitis on the risk of prostate cancer (PCa) in patients using nationally representative data of the Korean population from the National Health Insurance Service.

Materials And Methods: A total of 5,580,495 Korean men, aged >20 years, who had undergone health screening in 2009 were followed-up for 9 years until 2017. Multivariate adjusted Cox regression analysis was conducted to determine the hazard ratio (HR) and 95% confidence interval (CI) for the association between BPH and/or prostatitis and PCa. Read More

PLoS Negl Trop Dis 2020 03 20;14(3):e0008126. Epub 2020 Mar 20.

Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul, Korea.

Trichomonas vaginalis (Tv), a protozoan parasite causing sexually-transmitted disease, has been detected in tissue of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa). IL-6, a mediator of chronic inflammation, induces the progression of prostate cancer, and influences the polarization of M2 macrophages, which are the main tumor-associated macrophages. We investigated whether IL-6 produced by human prostate epithelial cells stimulated with Tv induces the M2 polarization of THP-1-derived macrophages, which in turn promotes the progression of PCa. Read More

Medicine (Baltimore) 2020 Mar;99(12):e19540

Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese, Beijing, China.

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urinary system disease in men. As part of traditional Traditional Chinese medicine, acupuncture has been widely used in clinical practice. In order to evaluate the exact effect of acupuncture on the clinical efficacy of CP/CPPS, this experiment uses randomized controlled experiments. Read More