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J Ethnopharmacol 2022 May 14;294:115386. Epub 2022 May 14.

Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

Ethnopharmacological Relevance: Chronic prostatitis (CP) is a complex, intractable and prevalent urological disorder in men with no effective treatment. Guihuang formula (GHF) is a traditional Chinese medicine compound that is advantageous as a CP treatment, but its aetiology is poorly understood. Research and exploration of the mechanism of GHF will help the development of a potentially valuable drug for CP and provide deeper insight into CP. Read More

Phys Ther 2022 May 14. Epub 2022 May 14.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, 90033, USA.

Objective: Excessive pelvic floor muscle activity has been suggested as a source of pain in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Our objective was to determine whether men with CP/CPPS have changes in neural drive that impair their ability to relax pelvic floor muscles.

Methods: We recruited 90 men (42 with CP/CPPS and 48 in the control group [without a history of pelvic pain]). Read More

Expert Opin Pharmacother 2022 May 16. Epub 2022 May 16.

Department of Infectious Diseases, Vall d'Hebron Hospital Universitari, Barcelona, Spain.

Introduction: Bacterial prostatitis, acute or chronic, is one of the most prevalent urogenital infections in men. Its diagnosis requires the application of a careful methodology. Gram-negative bacilli are the most frequent causative agents, and in recent years, an increase in the frequency of multiresistant bacteria has been detected. Read More

Pain Res Manag 2022 4;2022:9448620. Epub 2022 May 4.

TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.

Evidence shows that chronic prostatitis/chronic pelvic pain syndrome hugely impacts the body and mind. The central mechanisms in patients with CP/CPPS resulted in increased attention as neuroimaging techniques developed. This review investigated the study design and major neuroimaging findings in CP/CPPS patients to provide comprehensive evidence. Read More

Int J Mol Sci 2022 Apr 25;23(9). Epub 2022 Apr 25.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Neurogenic inflammation and central sensitization play a role in chronic prostatitis/chronic pelvic pain syndrome. We explore the molecular effects of low-intensity shock wave therapy (Li-ESWT) on central sensitization in a capsaicin-induced prostatitis rat model. Male Sprague-Dawley rats underwent intraprostatic capsaicin (10 mM, 0. Read More

Andrologia 2022 May 12:e14455. Epub 2022 May 12.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a poorly understood disease. Accumulating evidence suggests that autoimmune dysfunction is involved in the development of CP/CPPS. Interleukin-17 (IL-17) is associated with the occurrence and development of several chronic autoimmune inflammatory diseases. Read More

Transl Androl Urol 2022 Apr;11(4):561-566

Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, China.

Background: Xanthogranulomatous prostatitis (XGP) is a rare disorder of the prostate. It presents as a hard fixed nodule on digital rectal examination (DRE), and may cause obstructive urinary symptoms and elevated serum prostate-specific antigen (PSA) levels, therefore mimicking prostate cancer (PCa) clinically and biochemically. Radiological features of XGP overlap with those of PCa, and the 2 conditions cannot be distinguished by pelvic multiparametric magnetic resonance imaging (mpMRI). Read More

Comput Math Methods Med 2022 2;2022:9227032. Epub 2022 May 2.

Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.

Objective: UPOINT clinical phenotype system was used to estimate the type III prostatitis patients. Put in the erectile dysfunction (ED) domain and analysis the ED domain's effect towards the UPOINT system.

Methods: A total of 126 patients with type III prostatitis were prospectively collected and classified in each domain of the UPOINT system, including urinary, psychosocial, organ-specific, infection, neurological/systemic, and tenderness. Read More

Clin Nucl Med 2022 May 11. Epub 2022 May 11.

From the Department of Radiology, Hospital of the University of Pennsylvania.

Abstract: Prostatic calculi are common and usually asymptomatic calcified stones frequently found incidentally in imaging or during the evaluation of benign prostatic hyperplasia. Those associated with chronic prostatitis can lead to bacterial colonization, inflammation, and blockage of secretory ducts, resulting in pelvic pain and lower urinary tract symptoms. Although PET tracers such as 18F-NaF and 18F-FDG have been used to assess metastatic and benign bone disorders, their comparative avidity in the domain of extraosseous and prostate calcification remains to be fully explored. Read More

Urology 2022 May 6. Epub 2022 May 6.

Department of Urology, Hamad Medical Corporation, Doha, Qatar; Department of Clinical Urology, Weil Cornell Medicine -Qatar, Doha, Qatar.

Objective: to evaluate the effectiveness of UPOINT based multimodal treatment on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and determine factors that could be associated with clinical improvement.

Methods: A retrospective study was conducted in Doha, Qatar including patients with CP/CPPS from the Middle East and North Africa. The UPOINT phenotyping system was used to classify patients and guide their multimodal therapy. Read More

J Immunol Res 2022 29;2022:4593598. Epub 2022 Apr 29.

Medico Cura Te Stesso Onlus, Modena, Italy.

Aim: We report an open spontaneous anecdotical retrospective survey of administration to 4000 fragile immune-depressed and multimorbid patients treated with a killed strain to enhance innate immunity, integrating the adaptative immune response for long-standing antinfectious resistance.

Methods: A total of 4000 patients (1900 men and 2100 women) with mild, moderate, or chronic disease, appealing to our Second Opinion Medical Consultation Network, signed an informed consent form and were injected subcutaneously with . The treatment was followed up to 6 months, completing the short form of the medical outcome health survey questionnaire (SF-36) directly by the patients or their parents and monitoring their health status regularly via telemedicine (Skype, WhatsApp, mail, etc. Read More

J Vet Intern Med 2022 May 7. Epub 2022 May 7.

Clinic of Small Animal Internal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian-University, Munich, Germany.

Background: Immunosuppressive treatment with glucocorticoids and cyclosporine increases the risk for positive urine cultures (PUCs) in dogs.

Objective: To investigate the prevalence and incidence of PUC in dogs diagnosed with cancer and treated with antineoplastic chemotherapy while distinguishing between subclinical bacteriuria (SB) and urinary tract infection (UTI).

Animals: Forty-six client-owned dogs with nonurogenital cancer treated with antineoplastic chemotherapy. Read More

BMC Cancer 2022 May 6;22(1):510. Epub 2022 May 6.

Creative Biosciences (Guangzhou) CO., Ltd, Guangzhou, 510530, Guangdong, China.

Background: Better prognostic outcome is closely correlated with early detection of bladder cancer. Current non-invasive urianalysis relies on simultaneously testing multiple methylation markers to achieve relatively high accuracy. Therefore, we have developed an easy-to-use, convenient, and accurate single-target urine-based DNA methylation test for the malignancy. Read More

Prostate Int 2022 Jun 11;10(2):92-95. Epub 2022 Mar 11.

Department of Urology, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea.

Background: We investigated the association between moderate-to-severe prostatitis-like symptoms and the predictors of benign prostatic hyperplasia (BPH) progression.

Methods: Men who underwent health checkups were analyzed. We classified symptoms as "moderate to severe" if the pain score according to the National Institutes of Health-Chronic Prostatitis Symptoms Index was ≥8 and predictors of the progression of BPH were defined as having a prostate-specific antigen (PSA) ≥1. Read More

Prostate Int 2022 Jun 29;10(2):96-107. Epub 2022 Mar 29.

Department of Urology, Kashihara, Nara, 634-8522, Japan.

The microbiome in various organs involves a vast network that plays a key role in the health and wellness of the human body. With recent advances in biological technologies such as high-throughput sequencing, transcriptomics, and metabolomics, it appears that the microbial signature varies dynamically among individuals, creating various roles in metabolism, local and systemic inflammation, and host immunity. Urinary and genital organs, including the prostate, seminal vesicles, and urinary bladder, are reservoirs of several bacterial, viral, and fungal communities. Read More

Asian J Urol 2022 Apr 11;9(2):139-145. Epub 2021 Sep 11.

San Filippo Neri Hospital, Department of Urology, Rome, Italy.

Objective: To assess the efficacy and safety of a treatment regimen based on rectal administration of Boswellia resin extract and propolis derived polyphenols in patients with type IIIa and type IIIb chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS).

Methods: Patients with type IIIa and type IIIb CP/CPPS received one rectal suppository a day for 15 days per month for 3 consecutive months. Participants were evaluated with National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptom Scores (IPSS), International Index of Erectile Function (IIEF), four-glass test, uroflowmetry, and prostate-specific antigen assessments at baseline and at Week 4, and Week 12. Read More

Appl Bionics Biomech 2022 23;2022:8260640. Epub 2022 Apr 23.

Urology Surgery (Andrology), The First Hospital of Qinhuangdao, Qinhuangdao, 066000 Hebei, China.

Chronic prostatitis is a very common and very difficult disease. Based on the mobile medical system, this paper carried out a correlation analysis on the psychological factors and the evaluation of premature ejaculation in patients with benign prostatic hyperplasia. The article first analyzes the application in the field of mobile medical and then introduces the prostate image segmentation method based on the geometric active contour model. Read More

Cureus 2022 Apr 25;14(4):e24481. Epub 2022 Apr 25.

Urology, University Hospital Virgen de la Arrixaca, Murcia, ESP.

Purpose Chronic pelvic pain syndrome (CPPS) is permanent pelvic pain of unknown etiology. Current theories suggest a multifactorial origin for CPPS, including urinary pathologies, psychosocial factors, prostate inflammation, infection, central sensitization of the nervous system, and muscular contractures or fibrosis. As there are no defined treatment protocols for CPPS, a multimodal approach is recommended. Read More

Exp Ther Med 2022 Jun 8;23(6):382. Epub 2022 Apr 8.

Department of Andrology, Ganzhou Municipal Hospital, Ganzhou, Jiangxi 341000, P.R. China.

Chronic pelvic pain syndrome (CPPS) and chronic prostatitis (CP) is difficult to distinguish from each other, herein termed CP/CPPS. The present study aimed at gaining further insight into the change in extracellular vesicles (EVs) in the prostatic fluid of males with CPPS. From December 2019 to November 2020, after clinical screening, 24 patients with CPPS without obvious urinary symptoms and 13 healthy male participants were included. Read More

Nihon Yakurigaku Zasshi 2022 ;157(3):164-167

Department of Pharmacology and Toxicology, Dokkyo medical university.

Men with benign prostatic hyperplasia (BPH) often experience symptoms of overactive bladder (OAB), and bladder outlet obstruction (BOO) is one of cause of BPH. It has been suggested that bladder myogenic microcontractions or micromotions may partly contribute to the development of urgency (bladder sensory (afferent) hypersensitivity) in OAB related to BOO. We have investigated the direct effects of drugs (β3-adrenoceptor agonists, α1-adrenoceptor antagonists, PDE type5 inhibitors) on the bladder afferent function in BOO rats. Read More

Zhen Ci Yan Jiu 2022 Apr;47(4):343-8

Department of Urinary Surgery, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China.

Objective: To observe the clinical curative effect of wentongzhenfa (warming and promoting technique of acupuncture) combined with extracorporeal shock wave in treatment of type Ⅲ prostatitis.

Methods: A total of 96 patients with type Ⅲ prostatitis were randomly divided into an observation group (48 cases) and a control group (48 cases). In the control group, the extracorporeal shock wave was combined with even-needling technique of acupuncture at Guanyuan (CV4), Mingmen (GV4), Zhongji (CV3), Zusanli (ST36), etc. Read More

Urologiia 2022 May(2):84-89

Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia.

Benign prostatic hyperplasia (BPH) and chronic prostatitis (CP) are among the most common causes of LUTS in men. LUTS occur on average in 62.5% of males, with irritative symptoms occurring in 51%, obstructive symptoms in 26%, and postmicturic symptoms in 17% of cases. Read More

Urologiia 2022 May(2):59-65

Federal Medical Research Centre of Fundamental and Translational Medicine, Novosibirsk, Russia.

Introduction: Chronic prostatitis (CP) is the most common cause of a disorder of not only sexual, but also reproductive functions in men, which is caused by a decrease in the quality of the ejaculate and is confirmed by a deterioration in spermogram parameters, up to oligoasthenoteratozoospermia and azoospermia. In such a situation, the onset of pregnancy in the natural cycle is impossible - even with a completely preserved reproductive function in a woman. As an active substance in the recovery of men with chronic prostatitis associated with secondary infertility, we proposed oxidised dextran in the form of a pharmaceutical composition, which was developed at Federal Research Centre for Fundamental and Translational Medicine, Novosibirsk, Russia; and produced by ANDROEXPERT Research and Manufacturing Company LTD, Novosibirsk, Russia. Read More

Urologiia 2022 May(2):43-53

Department of Andrology and Urology of National Medical Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov of the Ministry of Health of Russia, Moscow, Russia.

Introduction: Chronic prostatitis (CP) has long been considered one of the common causes of male infertility. The influence of therapy for CP on spermatogenesis is well studied. However, recently, especially in the era of the new coronavirus infection (COVID-19), much attention has been paid to the effects of cytokines on the pathogenesis of the inflammatory process, and their impact on male fertility. Read More

J Infect 2022 Apr 26. Epub 2022 Apr 26.

Infectious Diseases Unit, San Raffaele Scientific Institute, Milan, Italy.

Pak J Med Sci 2022 Mar-Apr;38(3Part-I):595-599

Xinxi Wang Department of Urology, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, Hunan Province, P.R. China.

Objectives: To study the therapeutic effects of combined tamsulosin hydrochloride and terazosin treatment for patients with chronic prostatitis Type-III b.

Methods: This study involved 180 patients with chronic prostatitis Type-III b treated between January 2018 and December 2020 conducted at Nanhua Hospital Affiliated to Nanhua University. Patients were randomly divided into two equal groups: one receiving oral terazosin hydrochloride tablets only (control group), and one orally receiving both tamsulosin hydrochloride sustained-release tablets and terazosin hydrochloride tablets (observation group). Read More

J Inflamm Res 2022 21;15:2551-2566. Epub 2022 Apr 21.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People's Republic of China.

Background: Chronic nonbacterial prostatitis (CNP) has a high incidence, low cure rate, and unclear pathogenesis. Here, we aimed to systematically identify effective diagnostic and therapeutic targets for CNP.

Methods: Prostate tissues were obtained from established mouse models and negative controls and were used for mRNA array sequencing and immunohistochemistry (IHC) staining. Read More

J Pain 2022 Apr 23. Epub 2022 Apr 23.

Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.

Perspective: This article presents differences in clinical characteristics based on a simple self-report method of classifying pain mechanisms for Urologic Chronic Pelvic Pain Syndrome patients. This method can be easily applied to other chronic pain conditions and may be useful for exploring pathophysiology in pain subtypes.

Disclosures: Funding for the MAPP Research Network was obtained under a cooperative agreement from National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH) [DK082315 (Andriole, G; Lai, H), DK082316 (Landis, J), DK082325 (Buchwald, D), DK082333 (Lucia, M), DK082342 (Klumpp, D; Schaeffer A), DK082344 (Kreder, K), DK082345 (Clauw, D; Clemens, JQ), DK082370 (Mayer, E; Rodriguez L), DK103227 (Moses, M), DK103260 (Anger, J; Freeman, M), DK103271 (Nickel, J)]. Read More

Vet Clin North Am Small Anim Pract 2022 May;52(3):581-608

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA.

Urinary tract infection (UTI) is commonly encountered in small animal general practice. Within the past 5 years, there have been changes to terminology, such as the renaming of asymptomatic bacteriuria to subclinical bacteriuria, as well as paradigm shifts in the management of UTI. In general, there is an emphasis for responsible antimicrobial stewardship and selecting treatment based on urine culture and sensitivity and treating symptomatic bacterial UTI with a shorter duration of antimicrobials. Read More

Nat Commun 2022 Apr 19;13(1):2133. Epub 2022 Apr 19.

Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA.

Autoimmune (AI) diseases can affect many organs; however, the prostate has not been considered to be a primary target of these systemic inflammatory processes. Here, we utilize medical record data, patient samples, and in vivo models to evaluate the impact of inflammation, as seen in AI diseases, on prostate tissue. Human and mouse tissues are used to examine whether systemic targeting of inflammation limits prostatic inflammation and hyperplasia. Read More