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IDCases 2019 24;15:e00493. Epub 2019 Jan 24.

Faculty of Medicine of the University of Porto, Infectious Diseases department, Centro Hospitalar de São João, Porto, Portugal.

Prostatitis is a clinical condition of difficult management and with limited antimicrobial options, especially in the setting of antimicrobial resistance. Recurrences are frequent and can be severe. Limited reports support the use of fosfomycin for chronic prostatitis by ESBL-producing bacteria. Read More

Urologiia 2018 Oct(4):81-87

I.P. Pavlov Ryazan State Medical University of Minzdrav of Russia, Ryazan, Russia.

Introduction: Concurrent chronic prostatitis (CP) plays an important role in the pathogenesis and progression of benign prostatic hyperplasia (BPH), increasing the severity of lower urinary tract symptoms (LUTS), lowering the quality of life, and increasing the risk of acute urinary retention. However, in the management of patients with BPH, the role of CP is not always taken into account.

Aim: To evaluate the effectiveness of integrated management of patients with CP and patients with co-occurring BPH and CP using a physiotherapeutic device Mavit for the treatment of inflammatory diseases of the prostate. Read More

Urologiia 2018 Oct(4):72-80

Novosibirsk TB Research Institute of Minzdrav of Russia, Novosibirsk, Russia.

The study aimed to characterize patients with newly diagnosed benign prostatic hyperplasia (BPH) and identify patterns that lead to late diagnosis of the disease.

Study Design: Simple open retrospective non-comparative study.

Material And Methods: To determine the frequency of requests for medical care for BPH, the study analyzed medical records of 3544 patients who sought outpatient urological care at the municipal polyclinic # 26 in Novosibirsk in 2013. Read More

Urologiia 2018 Oct(4):64-71

Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia, Novosibirsk, Russia.

Introduction: Chronic inflammation of the prostate leads to the formation of excess fibrous connective tissue, which hinders patients recovery and aggravates the symptoms.

Aim: This study aimed to confirm the correlation between inflammation and prostatic fibrosis and the abnormalities of urodynamic and microcirculation in the prostate gland in humans, and the possibility of increasing the effectiveness of treatment of patients with chronic nonbacterial prostatitis using antisclerotic therapy.

Material And Methods: The study was carried out in two stages. Read More

Biomed Res Int 2019 14;2019:2462561. Epub 2019 Jan 14.

Department of Biomedical Laboratory Science, Catholic Kwandong University, Gangneung, Republic of Korea.

Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. Read More

J Urol 2019 Feb 7. Epub 2019 Feb 7.

Urologiia 2018 Dec(6):144-148

Department of Urology and Human Reproductive Health with the course of Pediatric Urology-andrology of the Advanced Training and Specialist Professional Retraining Faculty FGBOU VO Rostov State Medical University, Russian Federation Ministry Of Healthcare, Rostov-on-Don, Russia.

Prostatitis is considered as heterogeneous group of the diseases attracting broad interest of researchers worldwide. The acute and chronic stages of the process, as particular categories of bacterial prostatitis, remain in the realities of modern practical and scientific urology with lively discussions. Despite a large number of domestic and international publications, consensus on many topical issues of bacterial prostatitis is currently not achieved. Read More

Urologiia 2018 Dec(6):108-114

FGBOU VO Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky of the Ministry of Health of Russia, Krasnoyarsk, Russia.

Aim: to study the course of chronic abacterial prostatitis with the inflammatory component (CAPIC) depending on the somatotype in men of the first period of mature age taking complex treatment with a use of local and systemic ozone therapy.

Materials And Methods: A total of 306 men of asthenic, normostenic and pyknic somatotypes with CAPIC were followed-up. Along with standard therapy, all patients received systemic and local ozone therapy. Read More

Urologiia 2018 Dec(6):101-106

Department of Polyclinic Therapy and Medical Rehabilitation with the course of Additional Professional Education Federal State Educational Institution of Higher Education Altai State Medical University of the Ministry of Health of the Russian Federation, Barnaul, Russia.

The aim of the study was to increase the efficiency of complex treatment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with the combined effect of magnetolaser therapy (MLT) and red light.

Materials And Methods: We examined and included in the study 120 men with a verified diagnosis of CP/CPPS (III B), at the stage of exacerbation. By envelope method, patients were divided into two randomized groups. Read More

J Med Ultrason (2001) 2019 Feb 8. Epub 2019 Feb 8.

Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Purpose: The relationship between blood flow and lower urinary tract disease was explored by measuring blood flow in the common iliac vein to examine the influence of pelvic congestion on lower urinary tract symptoms.

Methods: Color Doppler ultrasonography of the right common iliac vein was performed in 113 men and 60 women, who were outpatients of two Japanese hospitals. Average blood flow velocity and cross-sectional area of the vein were measured, and blood flow volume was calculated. Read More

Andrologia 2019 Feb 6:e13245. Epub 2019 Feb 6.

Department of TCM Surgery, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

This study aimed to investigate the mechanism of Jiedu Huoxue decoction (JDHXD) in type III prostatitis based on the NF-κB signalling pathway. Twenty-six Sprague-Dawley male rats were divided into blank control, model, positive (Prostate Plus), low-dose JDHXD, medium-dose JDHXD and high-dose JDHXD groups. Type III prostatitis rat model was established and confirmed with HE staining. Read More

Front Endocrinol (Lausanne) 2019 23;10. Epub 2019 Jan 23.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Interleukins (ILs) and related chronic inflammation have been found to contribute to the development of benign prostatic hyperplasia (BPH) in recent decades. As a late member of the ILs family, IL-21 receptor (IL-21R) can modulate cell proliferation, however, IL-21R activity in the prostate has not been examined. The current study aimed to elucidate a potential role of IL-21R in the development of BPH. Read More

J Infect Chemother 2019 Feb 1. Epub 2019 Feb 1.

Integrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.

Purpose: To assess the efficacy of a combined regimen of levofloxacin (LVFX) plus isepamicin (ISP) as prophylaxis for transrectal ultrasound-guided needle biopsy of the prostate (TRUSP-Bx).

Materials And Methods: Overall, 562 patients undergoing TRUSP-Bx were included in the present study. All patients were administered a single-dose of oral LVFX (500 mg) in the morning and intravenous ISP (400 mg) 60 min before biopsy. Read More

Inflammation 2019 Feb 4. Epub 2019 Feb 4.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu Province, China.

The exact etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still unknown, as a result, available therapeutic options for patients are far from satisfactory. Therefore, there is a need to develop a valid therapeutic approach that can ameliorate the manifestations of CP/CPPS. Fifty male C57BL/6 mice were randomly divided into five groups of ten mice each. Read More

BMC Urol 2019 Jan 31;19(1):13. Epub 2019 Jan 31.

Department of Urology, First Affiliated Hospital of Sun Yat-sen university, Guangzhou, 510080, China.

Background: Diagnosis of urethral cavernous hemangioma (UCH) is very rare. It can be easy to misdiagnose and mistreat due to its atypical clinical manifestations and a lack of relevant knowledge. The study is to explore the diagnosis, differential diagnosis, and treatment of UCH. Read More

Nat Rev Urol 2019 Jan 30. Epub 2019 Jan 30.

Department of Immunology, Institut Pasteur, Paris, France.

Nat Rev Urol 2019 Jan 29. Epub 2019 Jan 29.

Laboratory of Clinical Cytology and Semen Analysis, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, PR, Brazil.

Zika virus (ZIKV) is a re-emerging mosquito-transmitted flavivirus associated with congenital abnormalities in newborns and with Guillain-Barré syndrome in adults. The virus can also be sexually transmitted and can persist in the male genital tract. Studies evaluating the kinetics of ZIKV in seminal shedding of men who have been infected, as well as in animal and cellular models of infection, have shown that, in addition to the testis and epididymis, the prostate and seminal vesicles could also be involved in persistent ZIKV infection. Read More

Cochrane Database Syst Rev 2019 Jan 25;1:CD010871. Epub 2019 Jan 25.

Clinical Research Institute, Faculty of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.

Background: The genital infection caused by Chlamydia trachomatis (CT) is a common sexually transmitted infection (STI) globally. The infection is mainly asymptomatic in women, thus it can produce infertility and chronic pelvic pain. In men infection is mainly symptomatic, but can evolve to prostatitis. Read More

Int Braz J Urol 2019 Jan 5;45. Epub 2019 Jan 5.

Department of Internal Medicine, Medicalpark Gaziantep Hospital, Bahçeşehir University School of Medicine, Gaziantep, Turkey.

Background: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis.

Materials And Methods: Patients followed up for histopathologically verified diagnosis of prostate cancer and prostatitis in 2016-2017 at the Medicalpark Gaziantep Hospital Urology Clinic were included in the study. Native Thiol (NT), Total Thiol (TT), Dynamic Disulphide (DD) levels in serum were measured by a novel automated method. Read More

Zhongguo Zhen Jiu 2019 Jan;39(1):73-6

Shanxi University of CM, Taiyuan 030619, China.

The technical combination of acupuncture is a combination therapy based on the purpose of improving clinical efficacy. After years of clinical practice, the author has gradually summarized the dominant disease spectrum of combination therapy, especially for the treatment of difficult diseases such as male and dermatological. In the treatment of chronic prostatitis, the combination of acupuncture at "Zhibian (BL 54) through Shuidao (ST 28) therapy" is adopted. Read More

Arch Ital Urol Androl 2019 Jan 17;90(4):270-275. Epub 2019 Jan 17.

University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa.

Objective: To evaluate the diagnostic value of serum inflammation markers derived from complete blood count in diagnosis of prostate cancer (PCa).

Methods: We retrospectively analyzed the data of 621 patients who underwent prostate biopsy between March 2013 and April 2018. Age, prostate specific antigen (PSA), free PSA, platelet count, neutrophil count, lymphocyte count, monocyte count, prostate volume (PV) and pathology result of the patients were recorded. Read More

Arch Ital Urol Androl 2019 Jan 18;90(4):260-264. Epub 2019 Jan 18.

Department of Gynaecological and Urological Sciences, Sapienza University of Rome.

Introduction: Chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS) represents a challenge for the urologist, since the therapeutic efficacy does not always result in a satisfactory quality of life for the patients. Often the side effects of the medications used (antiinflammatories, antibiotics, alpha blockers) far outweighs the benefits gained with their admission. The choice of nutraceutical medications is preferred for their effectiveness, that has been accepted and proven by the scientific community, and for the low incidence of side effects. Read More

Arch Ital Urol Androl 2019 Jan 18;90(4):227-248. Epub 2019 Jan 18.

ASST Nord Milano.

The modern clinical research on prostatitis started with the work of Stamey and coworkers who developed the basic principles we are still using. They established the segmented culture technique for localizing the infections in the males to the urethra, the bladder, or the prostate and to differentiate the main categories of prostatitis. Such categories with slight modifications are still used according to the NIH classification: acute bacterial prostatitis, chronic bacterial prostatitis, Chronic Pelvic Pain Syndrome (CPPS) and asymptomatic prostatitis. Read More

Int Braz J Urol 2018 Dec 10;45. Epub 2018 Dec 10.

Department of Microbiology, Isparta City Hospital, Isparta, Turkey.

Objectives: To evaluate the frequency of NIH category IV prostatitis, and the use of expressed prostatic secretions tests in an effort to improve the reliability of prostate specific antigen as an indicator, to avoid unnecessary prostate biopsy.

Materials And Methods: 178 expressed prostatic secretion positive patients with serum prostate specific antigen levels of ≥ 2.5 ng / mL were included in present prospective study. Read More

Am J Physiol Renal Physiol 2019 Jan 9. Epub 2019 Jan 9.

Urology, Northwestern University, United States.

Chronic inflammation and prostate fibrosis have been identified as contributors to lower urinary tract symptoms, LUTS, pathophysiology in humans. It has been shown that transurethral infection of an Escherichia coli strain named CP1, which was isolated from a patient with chronic prostatitis, can lead to the develop of differential chronic inflammation and pain in certain mouse strains. Therefore, we hypothesized that differential inflammation would influence fibrotic response in the prostate. Read More

Chin J Integr Med 2019 Jan 9. Epub 2019 Jan 9.

Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.

The development of Chinese medicine and Western medicine andrology is based on different social background and academic systems, either Chinese medicine or Western medicine andrology has their limitations, therefore, integration of Chinese and Western medicine (ICWM) andrology is in a great need. After more than 30 years of development, andrology has made great achievements in the construction of specialized academic association, holding academic conferences and publication of academic monographs, and the research progress on this field is mainly in the combination of disease and syndrome, microdifferentiation of symptoms and signs and basic research development. However, the comprehensive theoretic system of ICWM andrology has not yet established, and the related studies are still on the primary stage. Read More

Front Physiol 2018 20;9:1855. Epub 2018 Dec 20.

Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania Luigi Vanvitelli, Naples, Italy.

Bacterial prostatitis is believed to be the leading cause of recurrent urinary tract infections (UTIs) in men under 50 years of age and occurs both as an acute febrile disease responsive to antibiotics and as a chronic infection that is often unresponsive to antibiotic treatment. is more commonly associated with UTIs in these abnormalities, especially in patients undergoing catheterisation. This pathogen is able to colonise the host's tissues and to cause disease thanks to the production of many virulence factors such as fimbriae, flagella, immune avoidance, host-damaging factors, and the ability to form crystalline biofilms. Read More

Rev Esp Geriatr Gerontol 2018 Dec 31. Epub 2018 Dec 31.

Servicio de Urgencias, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.

Objective: To compare the characteristics of acute bacterial prostatitis between patients ≥75 years old with those <75 years old attended in the Emergency Department.

Material And Methods: A descriptive and observational study was conducted with a prospective follow-up including all consecutive patients with acute bacterial prostatitis that were admitted during one year to the Emergency Department of a tertiary-care hospital. Data were collected for demographic variables, comorbidities, clinical and microbiological findings, treatment, outcome, and re-consultation at 30 days follow-up. Read More

Asian J Androl 2018 Dec 25. Epub 2018 Dec 25.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

MicroRNAs (miRNAs) are considered to be involved in the pathogenic initiation and progression of chronic nonbacterial prostatitis (CNP); however, the comprehensive expression profile of dysregulated miRNAs, relevant signaling pathways, and core machineries in CNP have not been fully elucidated. In the current research, CNP rat models were established through the intraprostatic injection of carrageenan into the prostate. Then, next-generation sequencing was performed to explore the miRNA expression profile in CNP. Read More

Am J Mens Health 2019 Jan-Feb;13(1):1557988318822572. Epub 2019 Jan 2.

3 National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China.

The objective of the current study was to explore the role of body mass index (BMI) in sperm quality and erectile function in Chinese males of infertile couples. A total of 28 fertility centers in different regions of China were enrolled. Patient data were collected from June 1, 2017, through October 31, 2017. Read More

World J Mens Health 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.

Purpose: To determine the role of metabolic syndrome (MetS) as a risk factor for acquired premature ejaculation (PE) after considering the various risk factors, such as lower urinary tract symptoms, erectile dysfunction, hypogonadism, and prostatitis.

Materials And Methods: From January 2012 to January 2017, records of 1,029 men were analyzed. We performed multivariate analysis to identify risk factors for PE, including the covariate of age, marital status, International Prostate Symptom Score, International Index of Erectile Function (IIEF) score, National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score, serum testosterone levels, and all components of MetS. Read More

Ther Adv Urol 2018 Dec 26;10(12):377-381. Epub 2018 Oct 26.

Urology Department, Fabia Mater Hospital, Rome, Italy.

Background: Chronic prostatitis/chronic pelvic pain syndrome (IIIB CP/CPPS) is a condition of unclear aetiology. Many approaches have been used without satisfactory results. The aim of this study is to evaluate the efficacy of once-daily 5 mg tadalafil in pain control and improving quality of life in patients affected by CP/CPPS. Read More

Andrologia 2018 Dec;50(11):e13126

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio.

Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, has been linked to sperm damage and male infertility. There are many sources of OS and inflammation including varicocele, tobacco usage, alcohol, obesity/metabolic syndrome, leukocytospermia, sexually transmitted disease (i.e. Read More

Andrologia 2018 Dec;50(11):e13093

Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.

The prostate is the seat of three major causes of morbidity: benign prostatic hyperplasia, prostate cancer and prostatitis, three conditions in which inflammation has been implicated. A state of inflammation of the prostate gland, originally incited by an infection, an autoimmune response, a neurogenic stimulus or another trigger may have consequences on prostate functionality. In fact, male fertility depends intrinsically on the content of prostatic fluid factors secreted by the prostatic epithelium. Read More

Nat Rev Urol 2018 Dec 18. Epub 2018 Dec 18.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. Read More

Med Sci Monit 2018 Dec 18;24:9196-9203. Epub 2018 Dec 18.

Department of Urology, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, Hubei, China (mainland).

BACKGROUND Prostatic calculi are common in urological treatments. Our major purpose in the present study was to explore the occurrence and composition of prostatic calculi, and investigate the effect of calcium oxalate (CaOx) on clusterin expression and lower urinary tract symptom (LUTS) in prostatitis and benign prostatic hyperplasia (BPH) patients with calculi. MATERIAL AND METHODS From December 2016 to January 2017, a total of 79 prostatitis patients aged more than 50 years were enrolled. Read More

Clin Lab 2018 Oct;64(11)

Prostate 2019 Apr 14;79(5):446-453. Epub 2018 Dec 14.

Research Laboratories, Nippon Shinyaku Co., Ltd., Minami-ku, Kyoto, Japan.

Background: Experimental autoimmune prostatitis (EAP) and prostatitis induced by 17β-estradiol treatment combined with castration (hormone/castration-induced prostatitis; HCP) are the most commonly used rodent models of nonbacterial prostatitis. We studied the effect of the phosphodiesterase 5 inhibitor tadalafil on chronic pelvic pain in two such models in rats.

Methods: EAP was induced by intradermal injection of rat prostate antigen and complete Freund's adjuvant on Days 0 and 28. Read More

Urol Int 2018 Dec 13:1-3. Epub 2018 Dec 13.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a recently described inflammatory disease with multiorgan involvement. Although there were reports of IgG4-related kidney disease or prostatitis, this disease rarely presents in the bladder. In this report, we describe a case of IgG4-RD arising from bladder wall. Read More

Evid Based Complement Alternat Med 2018 13;2018:1612948. Epub 2018 Nov 13.

School of Health and Biomedical Sciences, RMIT University, Australia.

Chronic prostatitis (CP) is a chronic inflammation in the prostate with unsatisfactory management. Danggui Beimu Kushen Wan (DBKW) is a classic formula developed 1800 years ago for patients with difficult urination and it has been widely utilized for CP in modern days. However, scientific understanding of DBKW on CP has not been systematically reviewed. Read More

Urology 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, Hitit University School of Medicine, Corum, Turkey.

Objective: To evaluate ultrasonically determined bladder wall thickness (BWT) and prostatic calcification presence, in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and to correlate the findings with patient characteristics and the urinary, psychosocial dysfunction, organ specific, infection and neurological/systemic symptoms, and tenderness (UPOINT) classification system.

Material And Methods: Between January 2008 and December 2017, data of 1294 patients diagnosed with chronic prostatitis, in a single urology clinic, meeting a number of selective inclusion/exclusion criteria, were retrospectively analyzed. Patients, compliant to fill out all requested questionnaires, between the ages of 21-65 years were included to the study. Read More

Prostate Int 2018 Dec 1;6(4):157-161. Epub 2018 Jun 1.

Department of Urology, Yonsei University College of Medicine, Seoul, Korea.

Background: We investigated the usefulness of inflammatory markers including the delta neutrophil index (DNI), erythrocyte sedimentation rate, C-reactive protein, and procalcitonin as early predictors of sepsis in patients with acute prostatitis (AP). In addition, we evaluated the efficacy of intermittent catheterization for the initial management of acute urinary retention (AUR) in patients with AP.

Materials And Methods: All patients who presented to the emergency department and were admitted to the urology department from January 2011 to December 2013 were retrospectively reviewed. Read More

Top Companion Anim Med 2018 Dec 8;33(4):105-108. Epub 2018 Sep 8.

Dipartimento di Medicina Veterinaria (DiMeV), Section of Surgery and Obstetrics, University of Bari Aldo Moro, Italy. Electronic address:

In last years, following the increased canine life expectancy and the rising attention pet-owners devote to their animals, several authors have carried on investigations concerning new techniques to early identify canine prostatic disorders that might affect the dog's quality of life. Prostatic disorders often have an asymptomatic onset and their early diagnosis is difficult: hence, they are usually identified at an advanced stage, only. Traditionally, the diagnosis of prostatic disorders is based on noninvasive tools, such as transrectal and abdominal palpation, seminal or prostatic fluid evaluation, and urinalysis and imaging. Read More

Antiinflamm Antiallergy Agents Med Chem 2018 Nov 28. Epub 2018 Nov 28.

ASST Santi Paolo e Carlo - University of Milan, Via Antonio di Rudini 8, 20100 Milano. Italy.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is reported in literature ranging from 1 to 14.2%. The aim of the present study was to assess the impact on patient's quality of life and symptoms of Flower pollen extract in association with vitamins (Deprox 500®) in comparison with Serenoa repens 320 mg (Permixon 320 mg® by Pierre Fabre) in patients with CP/CPPS. Read More

Prostate 2019 Mar 28;79(4):379-389. Epub 2018 Nov 28.

Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul, Korea.

Background: Trichomonas vaginalis (T. vaginalis) is the most common sexually transmitted parasite. It has been detected in prostatic tissue of patients with prostatitis and reported to be associated with chronic prostatitis and benign prostatic hyperplasia as well as prostate cancer. Read More

Am J Mens Health 2018 Nov 28:1557988318814663. Epub 2018 Nov 28.

1 Department of Rehabilitation Medicine, the First Affiliated Hospital of China Medical University, Shenyang, China.

This study aims to determine the effect of radial extracorporeal shock wave therapy (rESWT) versus drug when treating chronic pelvic pain syndrome (CPPS; type III B chronic prostatitis). The study included 45 participants with CPPS, divided into two groups: Group I comprised 25 participants, who were treated with rESWT (3,000 pulses each; pressure: 1.8-2. Read More

Mol Med Rep 2019 Jan 21;19(1):221-230. Epub 2018 Nov 21.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Chronic non‑bacterial prostatitis (CNBP) is a common urinary disease and no standard treatments are available at present. Although autophagy serves an important role in a variety of chronic diseases, its role in CNBP is yet to be fully elucidated. Therefore, the present study aimed to investigate the effects of rapamycin‑induced autophagy on CNBP by establishing a rat model. Read More

Sci Rep 2018 Nov 27;8(1):17420. Epub 2018 Nov 27.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, United States.

Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common syndrome with limited therapies and an unknown etiology. Previously, our laboratory has defined a potential role for pathogenic infection in disease onset. Intra-urethral infection with a uropathogenic Escherichia coli strain isolated from a CP/CPPS patient, CP1, induces prostatic inflammation and tactile allodynia in mice. Read More

F1000Res 2018 9;7. Epub 2018 Nov 9.

Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Read More