Search Our Scientific Publications & Authors

Int Cancer Conf J 2022 Jul 7;11(3):215-218. Epub 2022 May 7.

Department of Urology, Kyoto Prefectural University of Medicine, 465 Kajii-cho Kawaramachi-Hirokoji, Kyoto, 602-8566 Japan.

A 23-year-old man presented with complaints of macrohematuria and hematospermia and was referred to our hospital for further examination. Magnetic resonance imaging revealed a round 30 × 25 mm tumor in the right peripheral zone; hence, a rare prostate tumor was suspected. Grayscale transrectal ultrasonography (TRUS) was performed using the Aplio-i800 PVL-715RST-transducer and revealed a well-defined round tumor. Read More

Mod Pathol 2022 Feb 11. Epub 2022 Feb 11.

Department of Anatomical Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

NTRK-rearranged mesenchymal neoplasms mostly affect the soft tissues of pediatric patients. Given the responsiveness to selective NTRK inhibitors, it remains critical to identify those ultra-rare cases occurring in the viscera of adults. In five females and two males aged 18-53 years, we characterized visceral mesenchymal tumors harboring TPM3-NTRK1 [uterine cervix (N = 2), pleura, prostate], LMNA-NTRK1 (lung), SQSTM1-NTRK3 (heart), and NTRK3 rearrangement with unknown fusion partner (colon/mesocolon) with RNA sequencing, FISH, RT-PCR, and immunohistochemistry. Read More

Diagn Pathol 2022 Feb 6;17(1):22. Epub 2022 Feb 6.

Cancer Center, Department of Pathology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.

Background: SWItch Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex functions collectively as a tumor suppressor and the inactivation of any of its constituent components is frequently associated with tumor initiation and/or progression. Most SWI/SNF deficient tumors share common rhabdoid morphology. ARID1A is the most frequently dysregulated SWI/SNF subunit in human cancer and inactivation of ARID1A is frequent across carcinomatous types while very rarely drives the tumorigenesis of sarcomas. Read More

J Surg Case Rep 2021 Dec 30;2021(12):rjab576. Epub 2021 Dec 30.

Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Stromal tumours of the prostate are exceedingly rare, often presenting in patients in their fifth decade of life. They are classified as either stromal sarcomas, or stromal tumours of uncertain malignant potential (STUMP), the latter of which is known to have diverse clinical behaviour and thus surgical excision is often warranted. We present a case of a 71-year-old male, initially worked up by his family doctor due to mild obstructive voiding symptoms. Read More

Int J Cancer 2022 03 26;150(6):993-1006. Epub 2021 Nov 26.

Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Molibresib is an orally bioavailable, selective, small molecule BET protein inhibitor. Results from a first time in human study in solid tumors resulted in the selection of a 75 mg once daily dose of the besylate formulation of molibresib as the recommended Phase 2 dose (RP2D). Here we present the results of Part 2 of our study, investigating safety, pharmacokinetics, pharmacodynamics and clinical activity of molibresib at the RP2D for nuclear protein in testis carcinoma (NC), small cell lung cancer, castration-resistant prostate cancer (CRPC), triple-negative breast cancer, estrogen receptor-positive breast cancer and gastrointestinal stromal tumor. Read More

Genes Chromosomes Cancer 2022 02 23;61(2):63-70. Epub 2021 Oct 23.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Low-grade endometrial stromal sarcoma (ESS) is a hormone-responsive low-grade sarcoma typically occurring in the uterine corpus in women. Their genetic hallmarks are recurrent gene fusions involving JAZF1, partnering with either SUZ12 gene or less commonly with PHF1. Low-grade ESS-like sarcoma, or endometrioid stromal sarcoma, is exceptionally rare in males and has been reported to date only in two cases, one in the paratesticular area and the other of prostatic stromal origin. Read More

Mod Pathol 2021 11 7;34(11):2080-2081. Epub 2021 Aug 7.

Departments of Pathology, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Mod Pathol 2021 09 13;34(9):1763-1779. Epub 2021 May 13.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Tumors of purported specialized prostatic stromal origin comprise prostatic stromal sarcomas (PSS) and stromal tumors of uncertain malignant potential (STUMP). Prior studies have described their clinicopathologic characteristics, but the molecular features remain incompletely understood. Moreover, these neoplasms are morphologically heterogeneous and the lack of specific adjunctive markers of prostatic stromal lineage make precise definition more difficult, leading some to question whether they represent a specific tumor type. Read More

Clin Nucl Med 2021 04;46(4):348-349

From the Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy.

Abstract: A 79-year-old man presented with dysuria and increased serum prostate-specific antigen level (21 ng/mL). MRI revealed bulky prostate enlargement but was inconclusive in revealing neoplastic lesions. Nevertheless, because of high clinical suspicion for neoplasm, transrectal biopsy revealed stromal tumor of uncertain malignant potential mixed with foci of low-grade primitive prostate stromal sarcoma. Read More

Medicine (Baltimore) 2021 Jan;100(2):e24038

Department of Ultrasound Medicine, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia, 010017, China.

Rationale: Prostatic sarcoma (PS) is a very rare malignant tumor that accounts for <0.1% of prostate malignancies, and Ewing's sarcoma is an extremely rare form of PS.

Patient Concerns: We reported on a 64-year-old patient with PS and a 36-year-old patient with Ewing's sarcoma, both of whom were examined by contrast-enhanced ultrasonography (CEUS) before surgery. Read More

Urol Int 2021 20;105(3-4):206-214. Epub 2020 Nov 20.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Research Center for Genitourinary Oncology, Beijing, China.

Introduction: Prostatic stromal tumor of uncertain malignant potential (STUMP) is a rare disease that may coexist with prostate stromal sarcoma (PSS). We aimed to analyze the histological and clinical features of STUMP.

Methods: Twenty-three patients diagnosed with STUMP from 2008 to 2019 were included. Read More

Pathology 2021 Jan 13;53(1):12-25. Epub 2020 Nov 13.

Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

Prostatic stromal proliferations account for the majority of benign tumour-like lesions in the prostate. The most common is nodular hyperplasia, seen in a majority of elderly men. Diagnostic difficulty is encountered with some variants, including stromal hyperplasia with atypia, characterised by degenerative changes of myofibroblasts. Read More

J Endourol Case Rep 2019 2;5(4):174-177. Epub 2019 Dec 2.

Division of Urology, Baylor Scott & White Health, Temple, Texas.

Holmium laser enucleation of the prostate (HoLEP) has proven to be effective in benign proliferations of the prostate resulting in large prostatic volumes. It is a less-invasive surgical alternative to transurethral resection and surgical resection. Prostatic adenocarcinoma can incidentally be found in the enucleated tissue. Read More

Pathology 2020 Oct 2;52(6):643-648. Epub 2020 Aug 2.

Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Solitary fibrous tumour (SFT) is well-described in the urinary tract, but malignant examples are rare. We studied our experience with high grade malignant SFT of the prostate to address the degree of histological and immunophenotypical overlap with sarcomatoid carcinoma and prostatic stromal sarcoma. Four cases were identified from the surgical pathology consultation archives. Read More

J Surg Case Rep 2020 Jun 17;2020(6):rjaa165. Epub 2020 Jun 17.

Department of Organs Therapeutics, Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.

Sarcomas and related proliferative lesions of the specialized stroma of the prostate are very rare and have been classified into prostate stromal sarcoma (PSS) and prostatic stromal tumor of uncertain malignant potential based on histology. We herein describe a case of PSS. A 40-year-old male presented at a hospital with urinary distention. Read More

Mod Pathol 2020 09 29;33(9):1753-1763. Epub 2020 Apr 29.

Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada.

Glucocorticoid-induced TNF receptor (GITR) is an emerging immunotherapy target that is expressed at high levels on regulatory T cells. Agonistic anti-GITR antibodies have anti-tumor activity in cancer mouse models, and recent phase 1 trials have demonstrated their safe pharmacological profile. However, there is limited knowledge on the relationship between GITR expression and the tumor microenvironment. Read More

World J Clin Cases 2020 Feb;8(3):606-613

Department of Urology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529030, Guangdong Province, China.

Background: Prostatic stromal sarcoma presenting with rhabdoid features is extremely rare, and only four cases have been reported in the English-language literature to date. Accordingly, there is no absolute definition of this group of tumors as yet, and our overall understanding of its morphological features, therapeutic regimen and prognosis is limited.

Case Summary: A 34-year-old male patient was referred to our hospital to address a 2-mo history of hematuria and progressive dysuria. Read More

Brain Pathol 2020 03 27;30(2):226-234. Epub 2019 Aug 27.

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

The aggressive nature of malignant gliomas and their genetic and clinical heterogeneity present a major challenge in their diagnosis and treatment. Development of targeted therapy brought attention on detecting novel gene fusions, since they represent promising therapeutic targets (eg, TRK inhibitors in NTRK fusion-positive tumors). Using targeted next-generation sequencing, we prospectively analyzed 205 primary brain tumors and detected a novel PTPRZ1-ETV1 fusion transcript in 11 of 191 (5. Read More

Urology 2019 Oct 26;132:e3-e4. Epub 2019 Jun 26.

Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA. Electronic address:

We present a 53-year-old man with a multilocular solid and cystic mass measuring 19 cm on cross-sectional imaging. After undergoing pelvic mass excision, final histopathology confirmed the diagnosis of primary prostatic stromal tumor of uncertain malignant potential (STUMP). Prostatic STUMPs are rare mesenchymal tumors with diverse histologic patterns. Read More

Can J Urol 2019 02;26(1):9683-9685

Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Primary spindle cell sarcoma of the prostate is exceedingly rare and accounts for 0.1% of all prostatic cancers. Typically, the disease course is rapid and portends a short and dismal prognosis. Read More

Asian Cardiovasc Thorac Ann 2019 Mar 23;27(3):228-230. Epub 2019 Jan 23.

2 Department of Thoracic Surgery, Liverpool Heart & Chest Hospital, Liverpool, UK.

Endobronchial metastasis from extrapulmonary solid tumors is rare, and endobronchial metastasis from the prostate is even more unusual. An 80-year-old patient presented with significant dyspnea secondary to metastatic stromal cell sarcoma of the prostate, which occluded the right main bronchus. The tumor, causing complete collapse of the right lung, was found on computed tomography and confirmed by bronchoscopy. Read More

Clin Nucl Med 2019 Jan;44(1):45-47

Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Primary prostatic stromal sarcoma is an extremely rare disease that predominantly occurs in adults, accounting for only 0.1% of all prostate cancers. Prostatic stromal sarcoma is quite aggressive and can spread to lung, liver, bone, and other organs. Read More

J Surg Oncol 2018 Jun 7;117(8):1716-1720. Epub 2018 Jun 7.

Division of Urology, Department of Surgery, Sidney Kimmel Center for Prostate, and Urologic Cancers, Memorial Sloan-Kettering Cancer Center, New York, New York.

Background And Objectives: Prior small studies have reported a possible association between renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GISTs). In the largest known series, our objective was to describe the prevalence of RCC among patients with GISTs over 26 years at Memorial Sloan Kettering Cancer Center (MSKCC).

Methods: We retrospectively reviewed MSKCC's prospectively maintained sarcoma and RCC databases and identified all patients with both RCC and GIST between 1980 and 2016. Read More

Medicine (Baltimore) 2018 May;97(18):e0495

Department of Radiology, Department of Pathology, the First Affiliated Hospital of Dalian Medical University, Dalian Shi, Liaoning Sheng, China.

Rationale: prostatic stromal sarcoma is a very rare malignant tumor that accounts for <0.1% of prostate malignancy. PATIENT CONCERNS:: we reported a 49-year-old man presented with dysuria and hematuria, whose computed tomography examination showed an enlarged prostate gland with an irregular shape. Read More

Mod Pathol 2018 01;31(S1):S133-142

Robert J Tomsich Pathology and Laboratory Medicine Institute, Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.

Mesenchymal tumors of the prostate are rare but often cause considerable diagnostic difficulty when encountered. These may be either benign or malignant and can arise within the prostate gland or in adjacent tissues. This review covers prostatic stromal proliferations (prostatic stromal tumor of uncertain malignant potential and stromal sarcoma), solitary fibrous tumor, myofibroblastic proliferations, smooth muscle neoplasms (leiomyoma and leiomyosarcoma), gastrointestinal stromal tumor, schwannoma, rhabdomyosarcoma, sarcomatoid carcinoma, postradiation sarcoma, and mixed epithelial stromal tumor of the seminal vesicle. Read More

Hum Pathol 2018 06 16;76:9-16. Epub 2017 Dec 16.

Department of Pathology, The Johns Hopkins University School of Medicine, 21205 Baltimore, MD; Department of Pathology, The James Buchanan Brady Urological Institute, 21205 Baltimore, MD; Department of Pathology, The Johns Hopkins Hospital, 21287 Baltimore, MD. Electronic address:

In a previous array comparative genomic hybridization study, we detected common deletions of chromosomes 13 and 14 in prostatic stromal sarcoma and stromal tumor of uncertain malignant potential (STUMP). In this study, we performed whole-exome sequencing (WES) and fluorescence in situ hybridization to explore somatic mutations in 1 low-grade stromal sarcoma, 1 high-grade stromal sarcoma, and 12 STUMPs including 5 cases of degenerative atypia type, 1 myxoid type, 1 phyllodes type, and 5 cases of recently described round cell type. WES was successful on 13 cases that revealed frequent somatic copy number alterations including losses of chromosomes 13 (11 cases), 14 (11 cases), and 1p (9 cases), and partial or complete loss of chromosome 10 (7 cases). Read More

Cytojournal 2017 20;14:15. Epub 2017 Jun 20.

St. John Hospital and Medical Center, Detroit, MI, USA.

Prostatic stromal sarcomas (PSS) are rare solid organ mesenchymal sarcomas. PSS may pose difficult diagnostic challenges on fine needle aspiration biopsy. We report a 48-year-old man diagnosed with metastatic high grade prostatic stromal sarcoma by a CT-scan guided fine needle aspiration (FNA) biopsy of a right lower lung lobe nodule. Read More

Diagn Pathol 2017 Jul 7;12(1):50. Epub 2017 Jul 7.

Pathology Unit, Istituto Nazionale Tumori I. R. C. C. S. "Fondazione Pascale", Naples, Italy.

Background: Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described in the prostate. The present case is characterized by some peculiarities if compared with previously reported cases of prostatic malignant solitary fibrous tumor. Read More

Prostate 2017 Jul 8;77(10):1160-1166. Epub 2017 Jun 8.

Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Introduction: Adult prostatic sarcoma (PS) is a rare disease. While surgery is considered the standard approach, the role of other therapies is not completely established. We report results of the largest multicentric contemporary cohort of PS patients. Read More

Ann Pathol 2017 Jun 26;37(3):254-258. Epub 2017 May 26.

Service d'anatomie et cytologie pathologiques, hôpital Bretonneau, CHRU de Tours, boulevard Tonnelle, 37000 Tours, France. Electronic address: