Hum Pathol 2018 06 16;76:9-16. Epub 2017 Dec 16.
Department of Pathology, The Johns Hopkins University School of Medicine, 21205 Baltimore, MD; Department of Pathology, The James Buchanan Brady Urological Institute, 21205 Baltimore, MD; Department of Pathology, The Johns Hopkins Hospital, 21287 Baltimore, MD. Electronic address:
In a previous array comparative genomic hybridization study, we detected common deletions of chromosomes 13 and 14 in prostatic stromal sarcoma and stromal tumor of uncertain malignant potential (STUMP). In this study, we performed whole-exome sequencing (WES) and fluorescence in situ hybridization to explore somatic mutations in 1 low-grade stromal sarcoma, 1 high-grade stromal sarcoma, and 12 STUMPs including 5 cases of degenerative atypia type, 1 myxoid type, 1 phyllodes type, and 5 cases of recently described round cell type. WES was successful on 13 cases that revealed frequent somatic copy number alterations including losses of chromosomes 13 (11 cases), 14 (11 cases), and 1p (9 cases), and partial or complete loss of chromosome 10 (7 cases). Read More