109 results match your criteria Prostatic Stromal Sarcoma


Stromal sarcoma of the prostate.

Can J Urol 2019 Feb;26(1):9683-9685

Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Primary spindle cell sarcoma of the prostate is exceedingly rare and accounts for 0.1% of all prostatic cancers. Typically, the disease course is rapid and portends a short and dismal prognosis. Read More

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February 2019
8 Reads

Unusual endobronchial prostatic metastatic tumor occluding right main bronchus.

Asian Cardiovasc Thorac Ann 2019 Mar 23;27(3):228-230. Epub 2019 Jan 23.

2 Department of Thoracic Surgery, Liverpool Heart & Chest Hospital, Liverpool, UK.

Endobronchial metastasis from extrapulmonary solid tumors is rare, and endobronchial metastasis from the prostate is even more unusual. An 80-year-old patient presented with significant dyspnea secondary to metastatic stromal cell sarcoma of the prostate, which occluded the right main bronchus. The tumor, causing complete collapse of the right lung, was found on computed tomography and confirmed by bronchoscopy. Read More

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http://dx.doi.org/10.1177/0218492319827668DOI Listing
March 2019
6 Reads

18F-FDG PET/CT Imaging in an Adolescent Patient With Primary Prostatic Stromal Sarcoma.

Clin Nucl Med 2019 Jan;44(1):45-47

Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Primary prostatic stromal sarcoma is an extremely rare disease that predominantly occurs in adults, accounting for only 0.1% of all prostate cancers. Prostatic stromal sarcoma is quite aggressive and can spread to lung, liver, bone, and other organs. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9737
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http://dx.doi.org/10.1097/RLU.0000000000002372DOI Listing
January 2019
15 Reads

The association of renal cell carcinoma with gastrointestinal stromal tumors.

J Surg Oncol 2018 Jun 7;117(8):1716-1720. Epub 2018 Jun 7.

Division of Urology, Department of Surgery, Sidney Kimmel Center for Prostate, and Urologic Cancers, Memorial Sloan-Kettering Cancer Center, New York, New York.

Background And Objectives: Prior small studies have reported a possible association between renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GISTs). In the largest known series, our objective was to describe the prevalence of RCC among patients with GISTs over 26 years at Memorial Sloan Kettering Cancer Center (MSKCC).

Methods: We retrospectively reviewed MSKCC's prospectively maintained sarcoma and RCC databases and identified all patients with both RCC and GIST between 1980 and 2016. Read More

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http://dx.doi.org/10.1002/jso.25080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135662PMC
June 2018
32 Reads

Prostatic stromal sarcoma: A case report and literature review.

Medicine (Baltimore) 2018 May;97(18):e0495

Department of Radiology, b Department of Pathology, the First Affiliated Hospital of Dalian Medical University, Dalian Shi, Liaoning Sheng, China.

Rationale: prostatic stromal sarcoma is a very rare malignant tumor that accounts for <0.1% of prostate malignancy. PATIENT CONCERNS:: we reported a 49-year-old man presented with dysuria and hematuria, whose computed tomography examination showed an enlarged prostate gland with an irregular shape. Read More

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http://dx.doi.org/10.1097/MD.0000000000010495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392530PMC
May 2018
8 Reads

Mesenchymal tumors of the prostate.

Authors:
Jesse K McKenney

Mod Pathol 2018 Jan;31(S1):S133-142

Robert J Tomsich Pathology and Laboratory Medicine Institute, Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.

Mesenchymal tumors of the prostate are rare but often cause considerable diagnostic difficulty when encountered. These may be either benign or malignant and can arise within the prostate gland or in adjacent tissues. This review covers prostatic stromal proliferations (prostatic stromal tumor of uncertain malignant potential and stromal sarcoma), solitary fibrous tumor, myofibroblastic proliferations, smooth muscle neoplasms (leiomyoma and leiomyosarcoma), gastrointestinal stromal tumor, schwannoma, rhabdomyosarcoma, sarcomatoid carcinoma, postradiation sarcoma, and mixed epithelial stromal tumor of the seminal vesicle. Read More

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http://dx.doi.org/10.1038/modpathol.2017.155DOI Listing
January 2018
24 Reads

Whole-exome sequencing demonstrates recurrent somatic copy number alterations and sporadic mutations in specialized stromal tumors of the prostate.

Hum Pathol 2018 06 16;76:9-16. Epub 2017 Dec 16.

Department of Pathology, The Johns Hopkins University School of Medicine, 21205 Baltimore, MD; Department of Pathology, The James Buchanan Brady Urological Institute, 21205 Baltimore, MD; Department of Pathology, The Johns Hopkins Hospital, 21287 Baltimore, MD. Electronic address:

In a previous array comparative genomic hybridization study, we detected common deletions of chromosomes 13 and 14 in prostatic stromal sarcoma and stromal tumor of uncertain malignant potential (STUMP). In this study, we performed whole-exome sequencing (WES) and fluorescence in situ hybridization to explore somatic mutations in 1 low-grade stromal sarcoma, 1 high-grade stromal sarcoma, and 12 STUMPs including 5 cases of degenerative atypia type, 1 myxoid type, 1 phyllodes type, and 5 cases of recently described round cell type. WES was successful on 13 cases that revealed frequent somatic copy number alterations including losses of chromosomes 13 (11 cases), 14 (11 cases), and 1p (9 cases), and partial or complete loss of chromosome 10 (7 cases). Read More

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http://dx.doi.org/10.1016/j.humpath.2017.12.004DOI Listing
June 2018
39 Reads

Metastatic prostatic stromal sarcoma: A challenging diagnosis on fine-needle aspiration with broad differential diagnosis.

Cytojournal 2017 20;14:15. Epub 2017 Jun 20.

St. John Hospital and Medical Center, Detroit, MI, USA.

Prostatic stromal sarcomas (PSS) are rare solid organ mesenchymal sarcomas. PSS may pose difficult diagnostic challenges on fine needle aspiration biopsy. We report a 48-year-old man diagnosed with metastatic high grade prostatic stromal sarcoma by a CT-scan guided fine needle aspiration (FNA) biopsy of a right lower lung lobe nodule. Read More

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http://dx.doi.org/10.4103/cytojournal.cytojournal_46_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488594PMC
June 2017
22 Reads

A rare case of malignant solitary fibrous tumor in prostate with review of the literature.

Diagn Pathol 2017 Jul 7;12(1):50. Epub 2017 Jul 7.

Pathology Unit, Istituto Nazionale Tumori I. R. C. C. S. "Fondazione Pascale", Naples, Italy.

Background: Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described in the prostate. The present case is characterized by some peculiarities if compared with previously reported cases of prostatic malignant solitary fibrous tumor. Read More

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http://dx.doi.org/10.1186/s13000-017-0640-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501453PMC
July 2017
39 Reads

Adult prostatic sarcoma: A contemporary multicenter Rare Cancer Network study.

Prostate 2017 Jul 8;77(10):1160-1166. Epub 2017 Jun 8.

Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Introduction: Adult prostatic sarcoma (PS) is a rare disease. While surgery is considered the standard approach, the role of other therapies is not completely established. We report results of the largest multicentric contemporary cohort of PS patients. Read More

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http://dx.doi.org/10.1002/pros.23375DOI Listing
July 2017
46 Reads

[Prostate cancer histoseminar: Update of the 2016 WHO classification - case No. 7: STUMP (stromal tumor of uncertain malignancy potential) and low grade stromal sarcoma].

Authors:
Gaëlle Fromont

Ann Pathol 2017 Jun 26;37(3):254-258. Epub 2017 May 26.

Service d'anatomie et cytologie pathologiques, hôpital Bretonneau, CHRU de Tours, boulevard Tonnelle, 37000 Tours, France. Electronic address:

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http://dx.doi.org/10.1016/j.annpat.2017.02.007DOI Listing
June 2017
19 Reads

[Primary prostatic sarcoma - a rare malignancy].

Urologe A 2017 Jul;56(7):857-860

Urologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, München, Deutschland.

Primary prostatic sarcomas are rare, reportedly comprising less than 1% of all prostate malignancies. Most patients present with lower urinary tract symptoms due to bladder outlet obstruction. Prostate-specific antigen (PSA) is typically normal. Read More

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http://dx.doi.org/10.1007/s00120-017-0370-zDOI Listing
July 2017
5 Reads

[A new WHO classification of prostate tumors].

Arkh Patol 2016 Jul-Aug;78(4):32-42

N.A. Lopatkin Research Institute of Urology and Interventional Radiology, Branch, National Radiology Research Center, Ministry of Health of the Russian Federation, Moscow.

The paper reviews the 2016 WHO classification of prostate tumors, notes the alterations made, and describes approaches to the diagnosis of cancer types and grades. It also gives original photomicrographs from the authors' collection. The main alterations were as follows: - The types of prostate adenocarcinoma were added by pleomorphic giant-cell carcinoma; oncocytic (8290/3) and lymphoepithelial (8082/3) carcinomas were excluded. Read More

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http://dx.doi.org/10.17116/patol201678432-42DOI Listing
February 2017
5 Reads

Management of Recurrent Retroperitoneal Sarcoma (RPS) in the Adult: A Consensus Approach from the Trans-Atlantic RPS Working Group.

Authors:

Ann Surg Oncol 2016 10 1;23(11):3531-3540. Epub 2016 Aug 1.

Introduction: Retroperitoneal soft tissue sarcomas (RPS) are rare tumors. Surgery is the mainstay of curative therapy, but local recurrence is common. No recommendations concerning the best management of recurring disease have been developed so far. Read More

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http://dx.doi.org/10.1245/s10434-016-5336-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557018PMC
October 2016
31 Reads

The Prevalence of Prostatic Stromal Tumor of Uncertain Malignant Potential in Specimens Diagnosed as Prostatic Hyperplasia.

Arch Iran Med 2016 Jul;19(7):488-90

Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Prostatic stromal tumors of uncertain malignant potential (STUMPs) are rare tumors arising from the specialized prostatic stroma. These tumors share certain histological and clinical features of benign prostatic hyperplasia, resulting in misdiagnosis of STUMP as prostatic hyperplasia. However, in contrast to prostatic hyperplasia, occasional cases have been documented to recur rapidly after resection and few of them have progressed to prostatic stromal sarcoma and distant metastasis. Read More

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http://dx.doi.org/0161907/AIM.007DOI Listing
July 2016
36 Reads

Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.

Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17.

From the Department of Radiology and Biomedical Imaging (Y.L., J.M., S.C.B., A.C.W.) and Department of Pathology (J.S.), University of California, San Francisco, 505 Parnassus Ave, M-391, San Francisco, CA 94143-0628; Department of Radiology, Sir Ganga Ram Hospital, New Delhi, India (S.S.); and Department of Diagnostic Radiology, Oregon Health and Science University, Portland, Ore (F.V.C.).

Recent advances in magnetic resonance (MR) imaging of the prostate gland have dramatically improved the ability to detect and stage adenocarcinoma of the prostate, one of the most frequently diagnosed cancers in men and one of the most frequently diagnosed pathologic conditions of the prostate gland. A wide variety of nonadenocarcinoma diseases can also be seen with MR imaging, ranging from benign to malignant diseases, as well as infectious and inflammatory manifestations. Many of these diseases have distinctive imaging features that allow differentiation from prostate acinar adenocarcinoma. Read More

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http://dx.doi.org/10.1148/rg.2016150226DOI Listing
March 2017
16 Reads

Primary prostate sarcoma: how to manage following diagnosis at transurethral resection.

J Surg Case Rep 2016 May 3;2016(5). Epub 2016 May 3.

Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, UK.

Primary prostate sarcomas are rare, reportedly comprising just 0.7% of all prostate malignancies. Here, we present the case of a 66-year-old man who was diagnosed with prostate stromal sarcoma after undergoing a routine transurethral resection of prostate for bladder outflow obstruction. Read More

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http://dx.doi.org/10.1093/jscr/rjw065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855216PMC
May 2016
13 Reads

Treatment of prostatic stromal sarcoma with robot-assisted laparoscopic radical prostatectomy in a young adult: A case report.

Oncol Lett 2016 Apr 18;11(4):2542-2544. Epub 2016 Feb 18.

Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

The present study reports a rare case of prostatic stromal sarcoma (PSS) treated with a robot-assisted laparoscopic radical prostatectomy (RLRP). A 32-year-old man presented to the Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University (Hangzhou, China) with obstructive voiding symptoms that had persisted for 2 years. A computed tomography scan of the pelvis revealed an 8-cm prostatic mass protruding into the bladder. Read More

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http://dx.doi.org/10.3892/ol.2016.4249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812177PMC
April 2016
7 Reads

The utility of STAT6 and ALDH1 expression in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms.

Hum Pathol 2016 08 8;54:184-8. Epub 2016 Apr 8.

Division of Surgical Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231-2410. Electronic address:

Solitary fibrous tumor (SFT) diagnosis in prostate can be challenging on small biopsies. Prostatic stromal tumors of unknown malignant potential (STUMP) and SFT have overlapping features. NAB2-STAT6 gene fusions that were recently identified in various SFTs lead to nuclear translocalization of STAT6. Read More

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http://dx.doi.org/10.1016/j.humpath.2016.03.011DOI Listing
August 2016
23 Reads

Prostatic Stromal Tumor of Uncertain Malignant Potential Which Was Difficult to Diagnose.

Case Rep Urol 2015 29;2015:879584. Epub 2015 Dec 29.

Department of Pathology, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama, Toyama 930-8550, Japan.

Here, we report a case of stromal tumor of uncertain malignant potential (STUMP) that was difficult to diagnose. A 53-year-old male was found to have a hard nodule on digital rectal examination; magnetic resonance imaging revealed a large nodule on the left side of the prostate, indicating prostate cancer. However, pathological diagnosis of the biopsy specimen was benign prostatic hyperplasia. Read More

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http://dx.doi.org/10.1155/2015/879584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709648PMC
February 2016
12 Reads

Is it really an abscess? An unusual case of metastatic stromal cell sarcoma of the prostate.

Int J Surg Case Rep 2015 4;17:82-4. Epub 2015 Nov 4.

Department of General Surgery, The Canberra Hospital Building 6, Level 1, Yamba Drive, Garran, ACT 2605, Australia. Electronic address:

Introduction: Prostatic stromal sarcomas account for about 0.1% of all prostatic malignancies. Local recurrence into bladder, seminal vesicles and rectum has been documented. Read More

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http://dx.doi.org/10.1016/j.ijscr.2015.10.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701799PMC
January 2016
22 Reads

[Stromal Tumors of Uncertain Malignant Potential (STUMP) of the Prostate : A Case Report].

Hinyokika Kiyo 2015 Jun;61(6):245-8

The Department of Pathology, Ikeda City Hospital.

A 77-year-old man was seen at our hospital with the chief complaint of pollakisuria. Magnetic resonance imaging (MRI) showed a 25 mm cystic tumor with solid components behind the prostate. A transrectal biopsy for the prostate showed no evidence of malignancy. Read More

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June 2015
5 Reads

[Diagnosis and treatment of prostatic malignant mesenchymal tumors: Analysis of 20 cases].

Zhonghua Nan Ke Xue 2015 Apr;21(4):308-14

Objective: To explore the diagnosis, treatment, and prognosis of prostatic malignant mesenchymal tumors (PMMT).

Methods: We retrospectively analyzed the clinical and follow-up data about 20 cases of PMMT and reviewed the literature relevant to the diagnosis, treatment, and prognosis of the disease.

Results: Based on the results of pathology and immunohistochemistry, the 20 PMMT cases included leiomyosarcoma (n = 7), rhabdomyosarcoma (n = 5), prostatic stromal sarcoma (n = 3), chondrosarcoma (n = 1), and undifferentiated PMMT (n = 4). Read More

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April 2015
9 Reads

Epithelial-mesenchymal, mesenchymal-epithelial, and endothelial-mesenchymal transitions in malignant tumors: An update.

World J Clin Cases 2015 May;3(5):393-404

Simona Gurzu, Sabin Turdean, Attila Kovecsi, Anca Otilia Contac, Ioan Jung, Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, 540139 Tirgu Mures, Romania.

Epithelial-to-mesenchymal transition (EMT) represents conversion of an epithelial cell in an elongated cell with mesenchymal phenotype, which can occur in physiologic and pathologic processes such as embryogenesis (type 1 EMT), wound healing and/or fibrosis (type 2 EMT) and malignant tumors (type 3 EMT). The proliferation rate, metastasizing and recurrence capacity, as also the individualized response at chemotherapics, in both epithelial and mesenchymal malignant tumors is known to be influenced by reversible switch between EMT and mesenchymal-to-epithelial transition (MET). Although much research work has already been done in these fields, the specific molecular pathways of EMT, relating to the tumor type and tumor localization, are yet to be elucidated. Read More

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http://dx.doi.org/10.12998/wjcc.v3.i5.393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419103PMC
May 2015
4 Reads

Primary spindle cell sarcoma of the prostate and (18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings.

Authors:
Hakan Öztürk

Urol Ann 2015 Jan-Mar;7(1):115-9

Department of Urology, School of Medicine, Sifa University, Izmir, Turkey.

Background: Primary sarcoma of the prostate is extremely rare and accounts for 0.1% of all prostate cancers. This type of cancer is associated with poor prognosis due to aggressive biological behavior. Read More

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http://dx.doi.org/10.4103/0974-7796.148657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310101PMC
February 2015
4 Reads

Diagnosis of a gastrointestinal stromal tumor presenting as a prostatic mass: a case report.

World J Mens Health 2014 Dec 29;32(3):184-8. Epub 2014 Dec 29.

Department of Urology, Jeju National University School of Medicine, Jeju, Korea.

Gastrointestinal stromal tumors (GISTs) are an unusual and heterogeneous group of spindle cell tumors that can also appear on the exterior of the gastrointestinal tract (extra-GISTs). Despite the fact that extra-GISTs or large rectal GISTs can lead to the clinical impression of a prostatic mass, these tumors are, in general, excluded in the differential diagnosis of spindle cell tumors observed on prostate needle biopsy. Here, we present, in detail, a case of an extra-GIST identified on prostatic biopsy; the tumor was previously believed to be a primary prostatic stromal sarcoma in the differential diagnosis. Read More

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http://dx.doi.org/10.5534/wjmh.2014.32.3.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298822PMC
December 2014
20 Reads

Prostatic stromal sarcoma in an adolescent: the role of chemotherapy.

Rare Tumors 2014 Oct 18;6(4):5607. Epub 2014 Dec 18.

Pediatric Hematology and Oncology Division Department of Woman's and Child's Health, Padova University Hospital , Padova, Italy.

Prostatic stromal sarcoma (PSS) is a rare tumor that normally occurs in adult age. Its management relies mainly on surgery. We report the first case of PSS occurring in an adolescent. Read More

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http://dx.doi.org/10.4081/rt.2014.5607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274447PMC
October 2014
7 Reads

Histologic variability and diverse oncologic outcomes of prostate sarcomas.

Korean J Urol 2014 Dec 28;55(12):797-801. Epub 2014 Nov 28.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Primary prostate sarcomas are a rare type of prostate cancer that account for less than 0.1% of primary prostate malignancies. We analyzed the experience of a single institution with prostate sarcoma over 20 years. Read More

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http://dx.doi.org/10.4111/kju.2014.55.12.797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265713PMC
December 2014
5 Reads

Stromal tumor of uncertain malignant potential of the prostate.

Arch Pathol Lab Med 2014 Nov;138(11):1542-5

From the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.

Stromal tumor of uncertain malignant potential (STUMP) of the prostate is a rare tumor with a variable and unpredictable clinical course. Many STUMPs are diagnosed incidentally and never progress, while others may invade locally and rapidly recur after surgical intervention, and yet others may lead to distant metastasis and death. A wide array of histologic patterns is encompassed by STUMP, and distinguishing these tumors from prostatic stromal sarcoma or other causes of stromal expansion often proves difficult. Read More

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http://synapse.koreamed.org/Synapse/Data/PDFData/0003TRD/trd
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http://www.archivesofpathology.org/doi/abs/10.5858/arpa.2013
Publisher Site
http://dx.doi.org/10.5858/arpa.2013-0212-RSDOI Listing
November 2014
18 Reads

Management of primary retroperitoneal sarcoma (RPS) in the adult: a consensus approach from the Trans-Atlantic RPS Working Group.

Authors:

Ann Surg Oncol 2015 Jan 15;22(1):256-63. Epub 2014 Oct 15.

Background: Retroperitoneal soft tissue sarcomas (RPS) are rare tumors that include several well-defined histologic subtypes. Although surgery is the mainstay of curative therapy, no universally accepted recommendations concerning the best management have been developed to date. Optimization of the initial approach is critical for maximizing patient outcomes. Read More

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http://dx.doi.org/10.1245/s10434-014-3965-2DOI Listing
January 2015
159 Reads

Two different surgical approaches for prostatic stromal sarcoma: robot-assisted laparoscopic radical prostatectomy and open radical cysto-prostatectomy with ileal conduit.

Korean J Urol 2014 Sep 5;55(9):620-3. Epub 2014 Sep 5.

Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea.

Stromal sarcoma of the prostate is very rare and shows rapid growth, which consequently is related to poor prognosis. Recently, we treated two cases of prostatic stromal sarcoma: one with robot-assisted laparoscopic radical prostatectomy and the other with open radical cysto-prostatectomy with an ileal conduit. To the best of our knowledge, this is the first case report of a prostatic stromal sarcoma managed by use of a robotic procedure. Read More

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http://dx.doi.org/10.4111/kju.2014.55.9.620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165926PMC
September 2014
16 Reads

[Pharmacotherapy of solid tumors. New hopes and frustrations].

Internist (Berl) 2014 Oct;55(10):1220-7

Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Recent years have seen dramatic changes in the biological understanding and treatment of solid tumors. Based on the tumor biology, targeting agents have been developed which directly affect the underlying genetic or immunological changes found in specific tumor entities. Significant increases in survival have delivered the functional proof of the concept of targeted and immunological tumor therapy. Read More

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http://dx.doi.org/10.1007/s00108-014-3553-3DOI Listing
October 2014
10 Reads

Chimeric RNAs generated by intergenic splicing in normal and cancer cells.

Genes Chromosomes Cancer 2014 Dec 11;53(12):963-71. Epub 2014 Aug 11.

Department of Pathology, University of Virginia, Charlottesville, VA.

A hallmark of many neoplasias is chromosomal rearrangement, an event that commonly results in the fusion of two separate genes. The RNA and protein resulting from these gene fusions often play critical roles in cancer development, maintenance, and progression. Traditionally, these fusion products are thought to be produced solely due to DNA level changes and are therefore considered unique to cancer. Read More

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http://dx.doi.org/10.1002/gcc.22207DOI Listing
December 2014
6 Reads

Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma.

Case Rep Med 2014 8;2014:612496. Epub 2014 Jul 8.

The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

Background. Endometrial stromal sarcomas (ESS) are a subtype of gynaecological sarcomas characterized by the overexpression of hormone receptors. Hormone treatment is widely used in ESS but primary or acquired resistance is common. Read More

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http://dx.doi.org/10.1155/2014/612496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109292PMC
August 2014
6 Reads

[Prostatic stromal tumors of uncertain malignant potential (STUMP): a case report].

Ann Pathol 2014 Jun 22;34(3):233-6. Epub 2014 May 22.

Service d'urologie, CHU de Nantes, CHU Hôtel-Dieu, 1, place Alexis-Ricordeau, 44000 Nantes, France. Electronic address:

We report the case of a patient affected by a voluminous prostatic tumor for which the histological analysis conclude in a stromal tumor of uncertain malignant potential. This type of tumor is rare, but requires to be individualized to differentiate it from a benign prostatic hyperplasia or a sarcoma of the prostate. The therapeutic care must be made keeping in mind the risk of degeneration towards a malignant shape. Read More

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http://dx.doi.org/10.1016/j.annpat.2014.03.008DOI Listing
June 2014
11 Reads

Ewing sarcoma of the small bowel: a study of seven cases, including one with the uncommonly reported EWSR1-FEV translocation.

Histopathology 2014 Jun 25;64(7):1014-26. Epub 2014 Feb 25.

Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Aims: Primary Ewing sarcoma of the ileum has rarely been documented. Little is known about its pathogenesis and clinical implications, and it would be helpful to identify novel molecular markers. EWSR1-FEV translocation is exceedingly rare in Ewing sarcoma, as FEV expression is restricted to prostate, brain and serotonin neuroendocrine cells (NE) and related tumours. Read More

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http://dx.doi.org/10.1111/his.12350DOI Listing
June 2014
17 Reads

A young man with primary prostatic extra-gastrointestinal stromal tumor: a rare case report and review of the literature.

Int J Clin Exp Pathol 2014 15;7(4):1764-70. Epub 2014 Mar 15.

Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology Tianjin, China.

Mounting evidence demonstrates the presence of extragastrointestinal stromal tumor (EGIST) which originates from tissues outside the gastrointestinal (GI) tract and shares overlapping immunohistological features with gastrointestinal stromal tumor (GIST). GIST emanating from prostate is extremely rare. To our knowledge, there are only 3 definitely reported cases of primary prostatic EGIST. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014260PMC
February 2015
9 Reads

Prostate Stromal Tumor of Uncertain Malignant Potential: Case Report With 5-Year Follow-up.

Urol Case Rep 2014 Mar 12;2(2):43-4. Epub 2014 Mar 12.

Division of Urology, The Hospital of the University of Pennsylvania, Philadelphia, PA.

Prostate stromal tumor of uncertain malignant potential is a term used to describe a specialized proliferation of stromal cells within the prostate. Most of these tumors tend to be benign, but some can present with local invasion or progress to prostatic stromal sarcoma with distant metastasis. We report a case of a 62-year-old male patient who presented to us with a diagnosis of stromal tumor of uncertain malignant potential. Read More

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http://dx.doi.org/10.1016/j.eucr.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733021PMC
March 2014
6 Reads

Stromal prostatic sarcoma: a rare tumor with rare clinical and imaging presentation.

J Radiol Case Rep 2013 Jul 1;7(7):24-31. Epub 2013 Jul 1.

Department of Pathology, Complejo Hospitalario Universitario de VIGO (CHUVI), Pontevedra, Spain.

Adult prostatic stromal sarcoma is a rare malignant tumor. The main presenting symptom is urinary retention secondary to bladder outlet obstruction. Prostatic Specific Antigen level can be normal. Read More

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http://dx.doi.org/10.3941/jrcr.v7i7.1177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888162PMC
July 2013
3 Reads

Newly available antibodies with practical applications in surgical pathology.

Authors:
John K C Chan

Int J Surg Pathol 2013 Dec;21(6):553-72

1Queen Elizabeth Hospital, Hong Kong, SAR China.

Selected antibodies that have become available in recent years and have applications in diagnostic pathology are discussed. They include antibodies that are organ-related, provide information on cellular differentiation or histogenetic type, have predictive value in tumors, and highlight infective agents. PAX8 (paired box gene 8) is a marker expressed in the lower female genital tract, thyroid, and kidney and their tumors. Read More

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http://dx.doi.org/10.1177/1066896913507601DOI Listing
December 2013
7 Reads

Prostatic stromal hyperplasia with atypia.

Case Rep Urol 2013 28;2013:364124. Epub 2013 May 28.

Department of Urology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Prostatic stromal hyperplasia with atypia (PSHA) is a rare histologic finding diagnosed incidentally on prostate biopsies, transurethral resection specimens, and radical prostatectomy specimens. PSHA has a bizarre histologic appearance and these lesions often raise concern for sarcoma; however, their clinical course is indolent and does not include extraprostatic progression. We discuss a case of PHSA discovered on prostate biopsy performed for an abnormal digital rectal examination and review the literature on this rare pathologic finding. Read More

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http://dx.doi.org/10.1155/2013/364124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679763PMC
June 2013
6 Reads

Common chromosomal aberrations detected by array comparative genomic hybridization in specialized stromal tumors of the prostate.

Mod Pathol 2013 Nov 14;26(11):1536-43. Epub 2013 Jun 14.

Department of Pathology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.

Specialized stromal tumors of the prostate encompass stromal sarcoma and stromal tumors of uncertain malignant potential (STUMP). The molecular signature associated with stromal sarcoma and STUMP has not been unraveled. The study was conducted to detect the chromosomal imbalances in stromal sarcoma and STUMP by using array comparative genomic hybridization (aCGH). Read More

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http://dx.doi.org/10.1038/modpathol.2013.99DOI Listing
November 2013
25 Reads

Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies.

Transl Res 2013 Aug 6;162(2):77-92. Epub 2013 Apr 6.

Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Ill., USA.

The role of cyclooxygenase-2 (COX-2), its lipid metabolite prostaglandin E2 (PGE2), and Eicosanoid (EP) receptors (EP; 1-4) underlying the proinflammatory mechanistic aspects of Burkitt's lymphoma, nasopharyngeal carcinoma, cervical cancer, prostate cancer, colon cancer, and Kaposi's sarcoma (KS) is an active area of investigation. The tumorigenic potential of COX-2 and PGE2 through EP receptors forms the mechanistic context underlying the chemotherapeutic potential of nonsteroidal anti-inflammatory drugs (NSAIDs). Although role of the COX-2 is described in several viral associated malignancies, the biological significance of the COX-2/PGE2/EP receptor inflammatory axis is extensively studied only in Kaposi's sarcoma-associated herpes virus (KSHV/HHV-8) associated malignancies such as KS, a multifocal endothelial cell tumor and primary effusion lymphoma (PEL), a B cell-proliferative disorder. Read More

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http://dx.doi.org/10.1016/j.trsl.2013.03.004DOI Listing
August 2013
6 Reads
13 Citations

Anal phyllodes tumor in a male patient: a unique case presentation and literature review.

Diagn Pathol 2013 Mar 26;8:49. Epub 2013 Mar 26.

Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Unlabelled: Lesions of anogenital mammary-like glands are rare, and only 44 female cases have been reported. Herein, we describe a particularly rare case of phyllodes tumor of anogenital mammary-like glands in a 41-year-old male presenting anal bleeding. Papillectomy was performed. Read More

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http://dx.doi.org/10.1186/1746-1596-8-49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621362PMC
March 2013
12 Reads

Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.

Hum Pathol 2013 Jun 15;44(6):1125-30. Epub 2013 Jan 15.

Department of Pathology, University of Toronto, Ontario, Canada M5S 1A8.

Sirtuin, silent mating-type information regulation 2 homolog Saccharomyces cerevisiae 1 (SIRT1), is a protein that has been implicated in multiple mammalian functions including cell aging, stress resistance, and differentiation. SIRT1 has also been shown to be involved in multiple tumors. In addition, new pharmacotherapies have recently been approved that target SIRT1. Read More

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http://dx.doi.org/10.1016/j.humpath.2012.10.001DOI Listing
June 2013
9 Reads

Mesenchymal tumours of the bladder and prostate: an update.

Pathology 2013 02;45(2):104-15

Department of Pathology, Messejana State Hospital, Fortaleza, CE, Brazil.

Mesenchymal tumours of the urinary bladder and prostate are infrequent neoplasms. The body of literature is growing with isolated case reports and short series, and the majority of cases are benign neoplasms. Other than stromal tumour of uncertain malignant potential and prostatic stromal sarcoma, both neoplasms derived from the specific prostatic stroma, the mesenchymal neoplasms in these locations are identical to their counterparts seen in other organs. Read More

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http://dx.doi.org/10.1097/PAT.0b013e32835c768bDOI Listing
February 2013
6 Reads

Prostatic stromal sarcoma with neuroectodermal differentiation.

Diagn Pathol 2012 Dec 7;7:173. Epub 2012 Dec 7.

Department of Pathology, Medical center hospital, Kitasato Institute, Kitasato University, Saitama, Japan.

Unlabelled: Prostatic stromal sarcoma is a fairly rare tumor that constitutes approximately 0.1-0.2% of all prostatic cancers. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/1746-1596-7-173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542249PMC
December 2012
7 Reads

Favorable response to neoadjuvant chemotherapy and radiation in a patient with prostatic stromal sarcoma.

J Clin Oncol 2012 Nov 8;30(33):e353-5. Epub 2012 Oct 8.

James Buchanan Brady Urological Institute, Johns Hopkins Hospitals, Baltimore, MD, USA.

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http://ascopubs.org/doi/10.1200/JCO.2012.41.7758
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http://dx.doi.org/10.1200/JCO.2012.41.7758DOI Listing
November 2012
6 Reads

[Prostatic Stromal Tumors of Uncertain Malignant Potential (STUMP): definition, pathology, prognosis and management].

Prog Urol 2012 Oct 12;22(12):688-91. Epub 2012 Jul 12.

Service d'urologie, CHU Hôtel-Dieu, Nantes, France.

Prostatic Stromal Tumors of Uncertain Malignant Potential (STUMP) are rare tumor of the prostate of mesenchymal origin, accounting, with sarcoma for 0.1-0.2% of all malignant prostatic tumours. Read More

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http://dx.doi.org/10.1016/j.purol.2012.06.004DOI Listing
October 2012
13 Reads

Malignant mixed epithelial and stromal tumor of the kidney: report of the first male case.

Int J Urol 2013 Apr 19;20(4):448-50. Epub 2012 Sep 19.

Divisions of Urology, Yamanashi Prefectural Central Hospital, Yamanashi, Japan.

Mixed epithelial and stromal tumor of the kidney is a rare benign tumor that consists of both epithelial and stromal cells. To date, eight malignant cases have previously been reported in female patients only. We report the first case of malignant mixed epithelial and stromal tumor of the kidney in a male patient. Read More

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http://dx.doi.org/10.1111/j.1442-2042.2012.03155.xDOI Listing
April 2013
7 Reads