31,099 results match your criteria Prostate Carcinoma


Atypical Intraductal Proliferation Detected in Prostate Needle Biopsy is a Marker of Unsampled Intraductal Carcinoma and Other Adverse Pathological Features.

Histopathology 2019 Apr 23. Epub 2019 Apr 23.

Robert J. Tomsich Pathology and Laboratory Medicine Institute.

Aims: Intraductal proliferations of the prostate with more complexity and/or cytologic atypia than high-grade prostate intraepithelial neoplasia (HGPIN), but falling short of intraductal carcinoma (IDC-P) are described as "atypical intraductal proliferation" (AIP). When present in needle biopsy (NBX) without IDC-P, clinical significance is not known.

Methods And Results: Sixty-two NBX cases were diagnosed as AIP over 7 years with estimated incidence of 1%. Read More

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http://dx.doi.org/10.1111/his.13878DOI Listing

Survival analysis in dogs with urinary transitional cell carcinoma that underwent whole-body computed tomography at diagnosis.

Vet Comp Oncol 2019 Apr 23. Epub 2019 Apr 23.

Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.

This retrospective study aimed to evaluate factors associated with survival and to compare characteristics between tumour localizations in dogs with urinary transitional cell carcinoma (TCC) that underwent whole-body computed tomography (CT) at diagnosis. Dogs with histologically confirmed TCC that received medical therapy between 2010 and 2017 were included; dogs that underwent surgery or radiotherapy for the primary tumour were excluded. According to the CT findings, primary tumour localization (classified into the Bladder, Urethra, and Bladder & Urethra groups), prostate involvement, iliosacral lymphadenomegaly, sternal lymphadenomegaly, and metastasis to the bone and lung were evaluated for survival analysis. Read More

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http://dx.doi.org/10.1111/vco.12483DOI Listing

Immunohistochemical Expression of E- and N-Cadherin in Nodular Prostatic Hyperplasia and Prostatic Carcinoma.

J Microsc Ultrastruct 2019 Jan-Mar;7(1):19-27

Department of Pathology, Faculty of Medicine, Menoufia University, Shebein El Kom, Egypt.

Background: Different theories have been postulated to explain the development of nodular prostatic hyperplasia (NPH). Epithelial to mesenchymal transition (EMT) is a physiologic process in which the epithelial cells lose their polarity and cell-cell adhesion and acquire a mesenchymal phenotype.

Aim: The aim of the present study is to investigate the potential role of E- and N-cadherin in the induction of EMT in NPH and prostatic carcinoma. Read More

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http://dx.doi.org/10.4103/JMAU.JMAU_46_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442322PMC

Cribriform and glomeruloid acinar adenocarcinoma of the prostate-an intratumoural intraductal carcinoma?

Histopathology 2019 May;74(6):804-808

Institute of Pathology, University Hospital Bonn, Bonn, Germany.

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http://dx.doi.org/10.1111/his.13821DOI Listing

Survival Effect of Nephroureterectomy in Metastatic Upper Urinary Tract Urothelial Carcinoma.

Clin Genitourin Cancer 2019 Mar 29. Epub 2019 Mar 29.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) and Institut du Cancer de Montréal, Montréal, Québec, Canada.

Background: Few data examined the potential survival benefit of nephroureterectomy (NU) in the setting of metastatic upper urinary tract urothelial carcinoma (mUTUC). We hypothesized that a survival benefit might be associated with the use of NU in that setting and tested this hypothesis within a large population-based cohort.

Patients And Methods: Within the Surveillance, Epidemiology, and End Results database (2004-2014), we identified 1174 patients with mUTUC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15587673193008
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http://dx.doi.org/10.1016/j.clgc.2019.03.003DOI Listing
March 2019
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Prostate Specific Antigen Nadir After Radical Cystoprostatectomy in Patients With Benign Prostatic Tissue: A Benchmark To Define Biochemical Recurrence after Radical Prostatectomy.

Urol J 2019 Apr 20. Epub 2019 Apr 20.

Department of Urology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Purpose: Biochemical failure after radical prostatectomy has been defined based on retrospective studies in men who underwent RP for localized prostate cancer. Nevertheless, retrospective strategy and possibility of extra-prostatic extension overshadowed the accurateness of the aforementioned cut-off value. To define a more precise PSA nadir value, we estimated serum PSA after cystoprostatectomy in cases with bladder urothelial cancer and no evidence of prostate cancer. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4551DOI Listing
April 2019
1 Read

Extrahepatic Clinical Application of Vessel Tracking Software and 3D Roadmapping Tools: Preliminary Experience.

J Vasc Interv Radiol 2019 Apr 17. Epub 2019 Apr 17.

Division of Interventional Radiology, Department of Radiology, New York-Presbyterian Hospital/Weill Cornell Medical Center, 525 East 68th Street, P-518, New York, New York 10065. Electronic address:

This article demonstrates the use of a representative commercially available automated vessel-tracking software originally intended for liver-only application (Vessel Assist Flight Plan for Liver; GE) in 4 patients. Treatment settings included embolization of small bowel hemorrhage source, treatment of renal cell carcinoma, management of symptomatic benign prostate hypertrophy, and detection with subsequent closure of a mesenteric pseudoaneurysm. All patients were treated successfully. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10510443183174
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http://dx.doi.org/10.1016/j.jvir.2018.11.039DOI Listing
April 2019
1 Read

UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway.

Drug Dev Ind Pharm 2019 Apr 17:1-17. Epub 2019 Apr 17.

b Department of medical records management , the Second Affiliated Hospital of Mudanjiang Medical University , Mudanjiang , Heilongjiang , 157000 , P.R. China.

Purpose: Studies have determined that UNBS5162, recognized as a new naphthalimide, holds inhibitory effects in prostate and breast tumors, however its functional implication on gastric carcinoma is currently undetermined. Based on this, this study designed to assess the functional role of it on human gastric carcinoma and underlying mechanism of action.

Methods: Cell Counting Kit-8 (CCK-8) assay, transwell assay, and flow cytometry were used to assess capabilities of SGC-7901 cell proliferation, invasion/migration, and apoptosis, respectively. Read More

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http://dx.doi.org/10.1080/03639045.2019.1607870DOI Listing

Intraductal Carcinoma of the Prostate in the Absence of High Grade Invasive Carcinoma Represents a Molecularly Distinct Type of in situ Carcinoma Enriched with Oncogenic Driver Mutations.

J Pathol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Intraductal carcinoma of the prostate (IDC-P) most often appears associated with high grade invasive prostate carcinoma (PCa), where it is believed to represent retrograde spread. However, IDC-P rarely occurs as an isolated finding at radical prostatectomy or with concurrent low grade (Grade Group 1) invasive carcinoma. We hypothesized that isolated IDC-P (iIDC-P) in these unusual cases may represent a distinct in situ lesion and molecularly profiled 15 cases. Read More

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http://dx.doi.org/10.1002/path.5283DOI Listing
April 2019
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Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid.

Contrast Media Mol Imaging 2019 12;2019:3728563. Epub 2019 Mar 12.

Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland.

Mesoporous silicon (PSi) is biocompatible and tailorable material with high potential in drug delivery applications. Here, we report of an evaluation of PSi as a carrier platform for theranostics by delivering a radioactive ion beam- (RIB-) based radioactive lanthanoid into tumors in a mouse model of prostate carcinoma. Thermally hydrocarbonized porous silicon (THCPSi) wafers were implanted with Dy at the facility for radioactive ion beams ISOLDE located at CERN, and the resulting [Dy]THCPSi was postprocessed into particles. Read More

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http://dx.doi.org/10.1155/2019/3728563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434306PMC

Ga-PSMA PET thyroid incidentalomas.

Hormones (Athens) 2019 Apr 15. Epub 2019 Apr 15.

Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Introduction: Thyroid incidentaloma is defined as a thyroid lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for a non-thyroid disease. The aim of this review is to evaluate the prevalence and clinical significance of focal incidental radiolabelled prostate-specific membrane antigen (PSMA) uptake in the thyroid gland [PSMA thyroid incidentaloma (PTI)] revealed by PET/CT or PET/MRI.

Methods: A comprehensive literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted to find relevant published articles about the prevalence and clinical significance of PTIs detected by PET/CT or PET/MRI in patients studied for other oncologic purposes. Read More

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http://dx.doi.org/10.1007/s42000-019-00106-8DOI Listing
April 2019
1 Read

Prognostic Significance of Serum PSA Level and Telomerase, VEGF and GLUT-1 Protein Expression for the Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy.

Pathol Oncol Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Oncology Center, Maria Sklodowska - Curie Institute, Cracow Branch, Cracow, Poland.

The aim of the study was to evaluate prognosis for biochemical recurrence (BR) by analysing the pathological and biological characteristics of prostate cancer (PCa) after radical prostatectomy (RP). There were 130 men with clinically localized PCa in whom pretreatment serum PSA level and Ki-67, prostate specific membrane antigen (PSMA), glucose transporter-1 (GLUT-1), vascular endothelial growth factor (VEGF), microvessel density (MVD) and human telomerase reverse transcriptase (hTERT) proteins expression, based on number of immunohistochemically positive cells (labelling index), were retrospectively studied. In order to assess the prognostic significance of analysed variables in univariate and multivariate Cox analysis, patients were dichotomized based on cut-off points chosen by receiver operating characteristic (ROC) curves. Read More

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http://dx.doi.org/10.1007/s12253-019-00659-4DOI Listing

Depletion of PCAT-1 in head and neck cancer cells inhibits tumor growth and induces apoptosis by modulating c-Myc-AKT1-p38 MAPK signalling pathways.

BMC Cancer 2019 Apr 15;19(1):354. Epub 2019 Apr 15.

Department of Pathology, Saint Louis University, 1100 South Grand Boulevard, St. Louis, MO, 63104, USA.

Background: Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metastasis and aggressive phenotype. Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancers. The lncRNA prostate cancer-associated transcript 1 (PCAT-1) showed potential oncogenic roles in different cancers, however its role in HNSCC is not known. Read More

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http://dx.doi.org/10.1186/s12885-019-5562-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466688PMC
April 2019
1 Read

N-Terminal Domain Mediated Regulation of RORα1 Inhibits Invasive Growth in Prostate Cancer.

Int J Mol Sci 2019 Apr 4;20(7). Epub 2019 Apr 4.

Department of Molecular Bioscience, College of Biomedical Sciences, Kangwon National University, Chuncheon 24341, Korea.

Four members of the retinoic acid-related orphan receptor α (RORα) family (RORα1, RORα2, RORα3 and RORα4) are transcription factors that regulate several processes including circadian rhythm, lipid metabolism, cerebellar development, immune function, and cancer. Only two isoforms, RORα1 and 4, are specifically co-expressed in the murine and human. In the present study, we identified a specific N-terminal domain (NTD) of RORα1 that potentiated the downregulation of target genes involved in tumor progression and proliferation, based on results from RORα-deficient mouse embryonic fibroblasts and prostate carcinoma tissues. Read More

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http://dx.doi.org/10.3390/ijms20071684DOI Listing

The Impact of 68Ga-PSMA PET/CT and PET/MRI on the Management of Prostate Cancer.

Urology 2019 Apr 12. Epub 2019 Apr 12.

Specialist in Nuclear Medicine, Clinic of Nuclear Medicine, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.

Prostate-specific-membrane-antigen (PSMA) is a transmembrane protein with significantly increased expression in the cells and metastases of prostate carcinoma (PCa). PSMA-expression correlates with higher serum levels of prostate-specific-antigen (PSA) and a higher Gleason Score (GS). This finding has led to the development of novel imaging modalities such as 68Ga-/18F-labeled PSMA PET/CT and PET/MRI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295193034
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http://dx.doi.org/10.1016/j.urology.2019.04.004DOI Listing
April 2019
3 Reads

Thyroid Incidentaloma on 18F-fluorocholine PET/CT and 68Ga-PSMA PET/CT Revealing a Medullary Thyroid Carcinoma.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Nuclear Medicine, Tenon Hospital, AP-HP, Paris, France.

A 66-year-old man with prostate cancer underwent F-fluorocholine PET/CT and thereafter Ga-labeled prostate-specific membrane antigen PET/CT to explore a rising prostate-specific antigen level. Both PET/CT studies showed a thyroid incidentaloma of the right lobe. Neck ultrasound confirmed the presence of a 16-mm right thyroid nodule. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002559DOI Listing
April 2019
1 Read

Curcumin: a potent agent to reverse epithelial-to-mesenchymal transition.

Cell Oncol (Dordr) 2019 Apr 13. Epub 2019 Apr 13.

Department of Medical Biotechnology Research Center, School of Medicine, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran.

Background: Epithelial-to-mesenchymal transition (EMT) is involved in tumor progression, invasion, migration and metastasis. EMT is a process by which polarized epithelial cells acquire motile mesothelial phenotypic features. This process is initiated by disassembly of cell-cell contacts through the loss of epithelial markers and replacement of these markers by mesenchymal markers. Read More

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http://dx.doi.org/10.1007/s13402-019-00442-2DOI Listing
April 2019
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Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer.

J Exp Clin Cancer Res 2019 Apr 11;38(1):157. Epub 2019 Apr 11.

Affiliated Cancer Hospital and institute of Guangzhou Medical University; Key Laboratory of Protein Modification and Degradation; State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, Guangdong, China.

Background: Prostate cancer (PCa) remains a challenge worldwide. Due to the development of castration-resistance, traditional first-line androgen deprivation therapy (ADT) became powerlessness. Epidermal growth factor receptor (EGFR) is a well characterized therapeutic target to treat colorectal carcinoma and non-small cell lung cancer. Read More

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http://dx.doi.org/10.1186/s13046-019-1165-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460657PMC
April 2019
7 Reads

Microbiome and Cancers, With Focus on Genitourinary Tumors.

Front Oncol 2019 26;9:178. Epub 2019 Mar 26.

Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, Ancona, Italy.

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http://dx.doi.org/10.3389/fonc.2019.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443990PMC
March 2019
1 Read

Histone Deacetylase Inhibitor Modulates NKG2D Receptor Expression and Memory Phenotype of Human Gamma/Delta T Cells Upon Interaction With Tumor Cells.

Front Immunol 2019 27;10:569. Epub 2019 Mar 27.

Institute of Immunology, University Hospital Schleswig-Holstein, Kiel, Germany.

The functional plasticity and anti-tumor potential of human γδ T cells have been widely studied. However, the epigenetic regulation of γδ T-cell/tumor cell interactions has been poorly investigated. In the present study, we show that treatment with the histone deacetylase inhibitor Valproic acid (VPA) significantly enhanced the expression and/or release of the NKG2D ligands MICA, MICB and ULBP-2, but not ULBP-1 in the pancreatic carcinoma cell line Panc89 and the prostate carcinoma cell line PC-3. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445873PMC
March 2019
1 Read

Multiple primary malignancies of six organs in a Japanese male patient: A case report.

Mol Clin Oncol 2019 May 4;10(5):511-515. Epub 2019 Mar 4.

Department of Surgery, Saitama Medical Center, Jichi Medical University, Omiya-ku, Saitama 330-8503, Japan.

As a result of recent advances in diagnostic techniques and treatment modalities, the number of patients diagnosed with multiple primary malignancies has been increasing. We report the case of a 79-year-old male with multiple primary malignancies of three histological types in six different organs: Stomach, prostate, colon, urinary bladder, facial skin and pancreas, in chronological order. The first malignancy was upper gastric cancer diagnosed in 1998. Read More

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http://dx.doi.org/10.3892/mco.2019.1819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449908PMC
May 2019
2 Reads

Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.

Urol Int 2019 Apr 9:1-8. Epub 2019 Apr 9.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China,

Background: Large cell neuroendocrine carcinoma (LCNEC) of the prostate is an extremely rare entity, and the clinicopathological course, potential effective treatment, and prognosis are yet to be elucidated.

Materials And Methods: A systematic search in Pubmed, Embase, and Ovid from inception to January 2019 was conducted. We reviewed each individual case of prostatic LCNEC and summarized specific features and outcomes for this rare pathologic entity. Read More

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http://dx.doi.org/10.1159/000499883DOI Listing
April 2019
1 Read

Magnetic resonance imaging-guided transperineal prostate biopsy.

J Cancer Res Ther 2019 ;15(2):394-397

Department of Intervention, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Purpose: The purpose of the study is to assess the clinical value of magnetic resonance imaging (MRI)-guided transperineal prostate biopsy in the diagnosis of prostate disease.

Materials And Methods: The institutional ethics committee approved this study. MRI-guided transperineal prostate biopsy was performed on 78 patients who had presented to our hospital with a prostate-specific antigen level >4 ng/mL or with MRI scans suggesting prostate cancer between January 2015 and August 2017. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_725_18DOI Listing
January 2019
1 Read

miR-1-3p suppresses proliferation of hepatocellular carcinoma through targeting SOX9.

Onco Targets Ther 2019 22;12:2149-2157. Epub 2019 Mar 22.

Department of General Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, People's Republic of China,

Background: Liver cancer was the fourth leading cause of cancer-related death in 2015. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. miR-1-3p plays important roles in cancer, including prostate, bladder, lung cancer, and colorectal carcinoma. Read More

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https://www.dovepress.com/mir-1-3p-suppresses-proliferation-
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http://dx.doi.org/10.2147/OTT.S197326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434909PMC
March 2019
6 Reads

Increasing incidence and mortality related to liver cancer in Australia: time to turn the tide.

Aust N Z J Public Health 2019 Apr 8. Epub 2019 Apr 8.

Menzies Institute for Medical Research, University of Tasmania.

Objective: Assess national and jurisdictional incidence and mortality trends for primary liver cancer in Australia.

Methods: Analysis of Australian Cancer Incidence and Mortality data published in 2017 by the AIHW. Age-standardised rates (ASR) for 1982 to 2014/2015. Read More

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http://dx.doi.org/10.1111/1753-6405.12889DOI Listing
April 2019
2 Reads

The prognosis value of EphA3 and the androgen receptor in prostate cancer treated with radical prostatectomy.

J Clin Lab Anal 2019 Apr 8:e22871. Epub 2019 Apr 8.

Department of Clinical Laboratory, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Background: This study aimed to preliminarily assess the relationship between erythropoietin-producing hepatocellular carcinoma receptor A3 (EphA3) and androgen receptor (AR) protein expression levels and prognosis in prostate cancer (PCa) to better understand the role of EphA3 in the prognosis and progression of PCa.

Materials: We investigated the expression of EphA3 and AR in human PCa by immunohistochemistry.

Results: EphA3 and AR were both significantly upregulated in PCa, with expression mainly localized to the nucleus. Read More

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http://dx.doi.org/10.1002/jcla.22871DOI Listing
April 2019
1 Read

JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression.

Cell Biol Int 2019 Apr 8. Epub 2019 Apr 8.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Most traditional cytotoxic chemotherapeutic agents have poor aqueous solubility and significant toxicity. Hence, there is a need to develop molecule-targeted drugs. PD-L1 is associated with the prognosis of several cancer types, and blockade of PD-1/PD-L1 signaling increases the amplitude of anti-tumor immunity. Read More

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http://dx.doi.org/10.1002/cbin.11139DOI Listing
April 2019
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miR‑27b‑3p and miR‑607 cooperatively regulate BLM gene expression by directly targeting the 3'‑UTR in PC3 cells.

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Key Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, Guizhou 550025, P.R. China.

BLM RecQ like helicase (BLM) has a pivotal role in genetic recombination, transcription, DNA replication and DNA repair, which presents the possibility of using BLM as an anti‑cancer target for treatment. However, the post‑transcriptional control regulation of BLM gene expression is not fully understood and limits the application of drugs targeting BLM for carcinoma therapy in the future. MicroRNAs (miRNAs) inhibit gene expression through interaction with the 3' untranslated region (3'‑UTR) of mRNA at the post‑transcriptional stage. Read More

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http://dx.doi.org/10.3892/mmr.2019.10135DOI Listing
April 2019
3 Reads

circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer.

Dis Markers 2019 6;2019:2473652. Epub 2019 Mar 6.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.

Background: Circular RNAs have been implicated in various malignancies and can function as potential biomarkers for cancers. Reportedly, circSMARCA5 was downregulated in hepatocellular carcinoma and glioblastoma multiforme, but upregulated in prostate cancer. The functional roles and clinical significance of circSMARCA5 still remain unknown in the context of gastric cancer (GC). Read More

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http://dx.doi.org/10.1155/2019/2473652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431400PMC
March 2019
1 Read

A Case of Polymyalgia Rheumatica Following Robotic-Assisted Radical Prostatectomy for High-Grade Prostate Cancer.

Am J Case Rep 2019 Apr 7;20:474-477. Epub 2019 Apr 7.

Internal Medicine Consult Service, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA.

BACKGROUND Polymyalgia rheumatica (PMR) is a common rheumatic disease in patients over the age of 50 years. Underlying triggers for PMR are not well understood, but there have been reports of cases presenting prior to the diagnosis of prostate cancer, with one case of PMR presenting following prostatectomy. This report is of a case of PMR that presented following robotic-assisted radical prostatectomy for high-grade prostate cancer and includes a discussion of the possible associations. Read More

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http://dx.doi.org/10.12659/AJCR.914152DOI Listing
April 2019
1 Read

Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells.

Neoplasia 2019 Apr 3;21(5):450-458. Epub 2019 Apr 3.

Julius Bernstein Institute of Physiology, University of Halle-Wittenberg, Germany.

Epithelial-to-mesenchymal transition (EMT) is an important process of tumor progression associated with increased metastatic potential. EMT can be activated by external triggers such as cytokines or metabolic parameters (e.g. Read More

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http://dx.doi.org/10.1016/j.neo.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447725PMC
April 2019
1 Read

Hidden intra-mandibular carcinoma cuniculatum appearing in a patient with metastatic prostate cancer: a case report.

BMC Oral Health 2019 Apr 5;19(1):54. Epub 2019 Apr 5.

Department of Oral Medicine and Oral Surgery, University Hospital of Strasbourg, Strasbourg, France.

Background: Whereas the incidence of cancers increases, overall survival of cancerous patients improves. Preventing the onset of second primary cancer is a new public health challenge and requires a special attention from organ specialists. We report a rare case of carcinoma cuniculatum in a context of metastatic prostate cancer. Read More

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http://dx.doi.org/10.1186/s12903-019-0745-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451252PMC

Molecular characterization of neuroendocrine-like bladder cancer.

Clin Cancer Res 2019 Apr 5. Epub 2019 Apr 5.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia

Purpose: Neuroendocrine (NE) bladder carcinoma is a rare and aggressive variant. Molecular subtyping studies have found that 5-15% of muscle-invasive bladder cancer (MIBC) have transcriptomic patterns consistent with NE bladder cancer in the absence of NE histology. The clinical implications of this NE-like subtype have not been explored in depth. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3558DOI Listing
April 2019
1 Read

New phosphate derivatives of betulin as anticancer agents: Synthesis, crystal structure, and molecular docking study.

Bioorg Chem 2019 Mar 22;87:613-628. Epub 2019 Mar 22.

Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Organic Chemistry, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland.

Betulin derivatives exhibit an antiproliferative activity and have been tested for many cancer cell lines. This paper describes a new series of 3-phosphate derivatives of betulin bearing different substituents at C28 position. The synthesized compounds were tested in vitro for their antiproliferative effect against human leukemia (MV-4-11 and CCRF/CEM), lung carcinoma (A549), prostate cancer (DU 145), melanoma (Hs 294T) cell lines, and murine leukemia P388. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.060DOI Listing
March 2019
1 Read

A comparison of adult rhabdomyosarcoma and high grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, US. Electronic address:

Some rhabdomyosarcomas and sarcomatoid carcinomas with heterologous rhabdomyosarcomatous elements resemble high-grade neuroendocrine carcinoma, creating a diagnostic difficulty. The purpose of this study was to characterize the overlap of adult genitourinary rhabdomyosarcomas, excluding those occurring at paratesticular sites, with high-grade neuroendocrine carcinoma and identify features helpful in their separation. Seventeen cases of rhabdomyosarcoma (eleven from the urinary bladder and three each from kidney and prostate) were compared to ten cases of high-grade neuroendocrine carcinoma from the urinary bladder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193005
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http://dx.doi.org/10.1016/j.humpath.2019.03.007DOI Listing
April 2019
11 Reads

A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties.

Dalton Trans 2019 Apr 4. Epub 2019 Apr 4.

Centre for Synthesis and Chemical Biology, Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

Immunocompromised cancer patients are often at high risk of developing infections. Standard infection control measures are required to prevent the onset of infection but, under some circumstances, antimicrobial prophylaxis is necessary. We have developed a family of innovative metallo-antibiotics of general formula [Cu(N,N)(CipA)Cl] where N,N represents a phenanthrene ligand and CipA stands for a derivative of the clinically used fluoroquinolone antibiotic ciprofloxacin. Read More

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http://dx.doi.org/10.1039/c9dt00250bDOI Listing
April 2019
1 Read

Overexpression of malignant brain tumor domain containing protein 1 predicts a poor prognosis of prostate cancer.

Oncol Lett 2019 May 5;17(5):4640-4646. Epub 2019 Mar 5.

Department of Urology, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.

Malignant brain tumor domain containing protein 1 (MBTD1) is a member of the polycomb group protein family that is associated with tumorigenesis. The present study investigated the role of MBTD1 within defined clinicopathological parameters and the prognosis of patients with prostate cancer (PCa). A human tissue microarray containing samples from 71 patients with PCa and seven healthy donors was employed for immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.3892/ol.2019.10109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444442PMC
May 2019
2 Reads
0.987 Impact Factor

Nivolumab versus everolimus in advanced renal cell carcinoma: Japanese subgroup 3-year follow-up analysis from the Phase III CheckMate 025 study.

Jpn J Clin Oncol 2019 Apr 3. Epub 2019 Apr 3.

Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan.

Background: Nivolumab treatment resulted in superior efficacy and safety versus everolimus treatment in the 2-year follow-up of the CheckMate 025 Phase III study, with consistent results in the global population and the Japanese population. Here, we report the 3-year follow-up in both groups.

Methods: Patients were randomized 1:1 to nivolumab 3 mg/kg intravenously every 2 weeks or everolimus 10 mg orally once daily until progression/intolerable toxicity. Read More

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http://dx.doi.org/10.1093/jjco/hyz026DOI Listing
April 2019
4 Reads
1.747 Impact Factor

Long noncoding RNA UCA1 acts as a sponge of miR-204 to up-regulate CXCR4 expression and promote prostate cancer progression.

Biosci Rep 2019 Apr 2. Epub 2019 Apr 2.

Department of Urology, Shanghai Minhang Hospital,Fudan University, Shanghai, China

Prostate cancer is a malignant disease with a poor prognosis. The aim of current study is to investigate the role of lncRNA-urothelial carcinoma associated 1 (UCA1) in the progression of PCa. We evaluated the expression levels of UCA1 in a total of 16 benign prostatic hyperplasia tissues (BPH) and 40 prostate cancer (PCa) tissues, as well as PCa cells. Read More

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http://dx.doi.org/10.1042/BSR20181465DOI Listing
April 2019
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A Case of Metastatic Prostate Cancer to the Urethra that Resolved after Androgen Deprivation Therapy.

Urology 2019 Mar 29. Epub 2019 Mar 29.

Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.

An 83 year-old male with Gleason score 4+3 prostatic adenocarcinoma status post brachytherapy developed obstructive voiding symptoms nine years after brachytherapy. PSA was 0.67. Read More

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http://dx.doi.org/10.1016/j.urology.2019.03.022DOI Listing

Exploring the MIR143-UPAR Axis for the Inhibition of Human Prostate Cancer Cells In Vitro and In Vivo.

Mol Ther Nucleic Acids 2019 Feb 27;16:272-283. Epub 2019 Feb 27.

Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, University of Leipzig, Leipzig, Germany.

MIR143 is pathologically downregulated and may function as a tumor suppressor in prostate cancer. Likewise, the urokinase plasminogen activator receptor (UPAR) is overexpressed in prostate carcinoma, representing a negative prognostic marker and putative therapeutic target gene. In this paper, we establish UPAR as a new direct target of MIR143. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444223PMC
February 2019
2 Reads

Survey of dentin sialophosphoprotein and its cognate matrix metalloproteinase-20 in human cancers.

Cancer Med 2019 Apr 1. Epub 2019 Apr 1.

Department of Diagnostic and Biomedical Sciences, University of Texas School of Dentistry at Houston, Houston, Texas.

Background: Matrix metalloproteinases-20 (MMP20) expression is widely regarded as tooth specific, with expression limited to dental hard tissues. Recently, we reported MMP20 expression and interaction with dentin sialophosphoprotein (DSPP), a member of the Small Integrin Binding Ligand N-linked Glycoproteins (SIBLINGs), in human oral squamous cell carcinoma (OSCC) and dysplastic oral premalignant lesions (OPLs), suggesting a role for MMP20-DSPP interaction in oral carcinogenesis.

Methods: This study aimed to survey the expression of MMP20 and its cognate DSPP partner in the breast, colon, prostate, thyroid, and cervical neoplasms. Read More

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http://dx.doi.org/10.1002/cam4.2117DOI Listing
April 2019
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American Society of Clinical Oncology Genitourinary Symposium and Integrative Healthcare Symposium.

Authors:
Walter Alexander

P T 2019 Apr;44(4):204-209

From ASCO, we report on metastatic castrate-resistant prostate cancer and locally advanced/metastatic renal cell carcinoma. From IHS, we report on complementary and alternative medicine use by patients and practitioners, the effects of biological hemp-derived cannabidiol on PTSD in military veterans, and more. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428497PMC
April 2019
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Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets.

Pathol Oncol Res 2019 Mar 29. Epub 2019 Mar 29.

Dental Research Center, Dentistry Research Institute, Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

All different types of metabolism of tumors are dependent on the flow of water molecules through the biological membrane, where fluid transfer interceded by aquaporins (AQPs) are the basis means for water entrance into the cells or outside them. Aquaporins play other roles including cellular migration, cellular expansion and cellular adhesion facilitation. Therefore, regulators of AQPs may be useful anticancer agents. Read More

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http://dx.doi.org/10.1007/s12253-019-00646-9DOI Listing

Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth.

Gene Ther 2019 Mar 29. Epub 2019 Mar 29.

Viral Vector Laboratory, Center for Translational Investigation in Oncology/LIM24, Cancer Institute of São Paulo, School of Medicine, University of São Paulo, SP, Brazil.

For patients with metastatic prostate cancer, the 5-year survival rate of 31% points to a need for novel therapies and improvement of existing modalities. We propose that p53 gene therapy and chemotherapy, when combined, will provide superior tumor cell killing for the treatment of prostate carcinoma. To this end, we have developed the AdRGD-PGp53 vector which offers autoregulated expression of p53, resulting in enhanced tumor cell killing in vitro and in vivo. Read More

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http://dx.doi.org/10.1038/s41434-019-0071-xDOI Listing
March 2019
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Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma.

Elife 2019 Apr 1;8. Epub 2019 Apr 1.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, United States.

While genomic sequencing routinely identifies oncogenic alterations for the majority of cancers, many tumors harbor no discernable driver lesion. Here, we describe the exceptional molecular phenotype of a genomically quiet kidney tumor, clear cell papillary renal cell carcinoma (CCPAP). In spite of a largely wild-type nuclear genome, CCPAP tumors exhibit severe depletion of mitochondrial DNA (mtDNA) and RNA and high levels of oxidative stress, reflecting a shift away from respiratory metabolism. Read More

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http://dx.doi.org/10.7554/eLife.38986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459676PMC
April 2019
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Neuroendocrine cells of prostate cancer: biologic functions and molecular mechanisms.

Asian J Androl 2019 Mar 22. Epub 2019 Mar 22.

Department of Pathology, Duke University School of Medicine, Durham, NC 27514, USA.

Prostate cancer (PCa) is a major health risk for older men worldwide. Existing systemic therapies mostly target androgen receptor (AR). Although treatments are initially effective, the disease always recurs. Read More

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http://dx.doi.org/10.4103/aja.aja_128_18DOI Listing
March 2019
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A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells.

Cancer Lett 2019 Jun 25;452:158-167. Epub 2019 Mar 25.

Biochemistry Service, Vall d'Hebron University Hospital and Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129, Barcelona, 08035, Spain. Electronic address:

PTOV1 is a transcription and translation regulator and a promoter of cancer progression. Its overexpression in prostate cancer induces transcription of drug resistance and self-renewal genes, and docetaxel resistance. Here we studied PTOV1 ability to directly activate the transcription of ALDH1A1 and CCNG2 by binding to specific promoter sequences. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.03.019DOI Listing

Molecular analysis and literature-based hypothesis of an immunonegative prostate small cell carcinoma causing ectopic ACTH syndrome.

Endocr J 2019 Mar 28. Epub 2019 Mar 28.

Department of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.

Ectopic ACTH syndrome (EAS) due to a prostate small cell carcinoma (SCC) is very rare with only 26 cases reported to date and has a poor prognosis. We here describe another case of this disorder that was clinically typical based on prior reports as it showed hypercortisolemia and severe hypokalemia with multiple metastasis. However, our current case of prostate SCC causing EAS is the first to display negative immunostaining for ACTH despite detectable POMC mRNA expression in the primary lesion. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0563DOI Listing

Whole Genome and Transcriptional Analysis of Treatment-Emergent Small Cell Neuroendocrine Prostate Cancer Demonstrates Intra-Class Heterogeneity.

Mol Cancer Res 2019 Mar 27. Epub 2019 Mar 27.

Medical Oncology, University of California, San Francisco.

Therapeutic resistance in metastatic castration resistant prostate cancer (mCRPC) can be accompanied by treatment-emergent small cell neuroendocrine carcinoma (t-SCNC), a morphologically distinct subtype. We performed integrative whole-genome and -transcriptome analysis of mCRPC tumor biopsies including paired biopsies after progression, and multiple samples from the same individual. t-SCNC was significantly less likely to have amplification of AR or an intergenic AR enhancer locus, and demonstrated lower expression of AR and its downstream transcriptional targets. Read More

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1101DOI Listing
March 2019
1 Read