Search Our Scientific Publications & Authors

Int J Comput Assist Radiol Surg 2019 Mar 13. Epub 2019 Mar 13.

Department of Electrical and Computer Engineering, University of British Columbia, 2332 Main Mall, Vancouver, BC, V6T 1Z4, Canada.

Purpose: Prostate cancer is the most prevalent form of male-specific cancers. Robot-assisted laparoscopic radical prostatectomy (RALRP) using the da Vinci surgical robot has become the gold-standard treatment for organ-confined prostate cancer. To improve intraoperative visualization of anatomical structures, many groups have developed techniques integrating transrectal ultrasound (TRUS) into the surgical workflow. Read More

Zhonghua Wai Ke Za Zhi 2019 Mar;57(3):200-205

Department of Urology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.

To explore the effects of various forms of prostatic apex on positive apical margin rate (PAM) and biochemical recurrence (BCR) after laparoscopic radical prostatectomy. A retrospective analysis of 309 patients (aging (65±6) years) who were experienced laparoscopic radical prostatectomy from January 2010 to December 2016 at the Department of Urology, First Affiliated Hospital of Fujian Medical University. According to the relationship between prostate apex and membrane urethra at the mid-sagittal plane of preoperative MRI, all patients were classified into 4 categories. Read More

Cancer 2019 Mar 12. Epub 2019 Mar 12.

Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, New York.

Cancer 2019 Mar 12. Epub 2019 Mar 12.

Department of Radiation Oncology, Azienda Socio Sanitaria Territoriale (ASST) della Valle Olona, Varese, Italy.

Asian J Androl 2019 Mar 12. Epub 2019 Mar 12.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Our previous study found that plate factor-4 variant (CXCL4L1) was downregulated in the serum of patients with prostate cancer (PCa). The aim of the present study was to investigate the prognostic value of CXCL4L1 in PCa. In total, 213 PCa patients treated with radical prostatectomy were enrolled and peripheral blood samples of all patients were collected. Read More

Turk Patoloji Derg 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, Cizre Dr. Selahattin Cizrelioğlu State Hospital, ŞIRNAK, TURKEY.

Objective: Prostate cancer is the second most common cancer in men. Digital rectal examination, transrectal ultrasonography and serum prostate specific antigen represents a diagnostic triad for the detection of prostatic carcinoma. About 50 years ago, Dr. Read More

Urologe A 2019 Mar 11. Epub 2019 Mar 11.

Urologische Klinik und Poliklinik, Klinikum der Universität München, Marchioninistraße 15, 81377, München, Deutschland.

In the prostate-specific antigen (PSA) era, most prostate cancers (PCa) are diagnosed in a localized stage and a plethora of therapeutic options are warranted in different clinical settings and disease stages of localized PCa. In the current narrative review, we give an overview of the current controversies in the therapeutic landscape of localized PCa and focus on organ-sparing approaches, percutaneous radiotherapy, brachytherapy as well as retropubic and robot-assisted prostatectomy by summarizing studies that have been published within the last two years. Read More

Urol Oncol 2019 Mar 8. Epub 2019 Mar 8.

Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Objective: To investigate the effect of the estimated blood loss (BL) during radical prostatectomy (RP) for prostate cancer (CaP) on functional outcomes. We hypothesized that the estimated BL during RP for clinically localized CaP does not affect the functional outcomes.

Materials And Methods: Patients who underwent open RP (ORP) or robotic-assisted laparoscopic RP (RALP) were identified. Read More

Arch Esp Urol 2019 03;72(2):203-210

Department of Urology. Hospital Universitario La Paz. Madrid. Spain. Instituto de Investigación Hospital Universitario La Paz (IdiPAZ). Madrid. Spain. Universidad Autónoma de Madrid. Madrid. Spain.

There are multiple definitions of high risk prostate cancer and each definition is associated with a different prognosis. Men classified as having high-risk disease warrant treatment because durable outcomes can be achieved. Radical prostatectomy, radiation therapy and androgen deprivation therapy play pivotal roles in the management of men with high-risk disease, and potentially in men with metastatic disease. Read More

Arch Esp Urol 2019 03;72(2):182-191

Department of Urology and Robot-assisted and Reconstructive Surgical Urology. University of Cologne. Cologne. Germany.

Oligometastatic prostate cancer (PCA) has increasingly been detected in the era of modern imaging studies such as choline-specific and prostate-specific membrane antigen (PSMA)-positron emission tomography and X-ray computed tomography (PET/CT). Recent evidence suggests that durable control is attainable with local treatment modalities such as salvage metastasectomy or stereotactic radiation therapy targeting oligometastases, either with or without the use of systemic therapy.The purpose of this article is to critically review the current findings on the indication, extent, and oncologic outcome of salvage lymphadenectomy (SLND). Read More

Arch Esp Urol 2019 03;72(2):174-181

University College London Hospital. NHS Foundation Trust. London. UK. Nuffield Department of Surgical Sciences. University of Oxford. Oxford. UK.

Introduction: Prostate cancer is the most common solid organ malignancy in men. Despite the implementation of PSA screening, the incidence of metastatic prostate cancer in Spain is still around 4%. In this clinical scenario, systemic treatment is the gold standard. Read More

Int J Surg Case Rep 2019 Mar 1;56:82-85. Epub 2019 Mar 1.

Department of Urology, Nagoya Tokushukai General Hospital, Kasugai City, Japan.

Introduction: The optimal management strategy for synchronous gastric cancer (GC) and prostate cancer (PCa) remains unclear, particularly in cases in which two cancers are progressive.

Presentation Of Case: A 68-year-old man diagnosed with synchronous advanced GC and locally advanced PCa was referred to our institution. Laparoscopic total gastrectomy (LTG) and robotic-assisted radical prostatectomy were simultaneously performed. Read More

World J Urol 2019 Mar 8. Epub 2019 Mar 8.

Radiation Oncology Princess Alexandra Raymond Terrace (ROPART), 31 Raymond Terrace, South Brisbane, QLD, Australia.

Purpose: Although the clinical significance of a diagnosis of prostate cancer for some men is debated, for many men it leads to significant morbidity and mortality. Radical treatment of clinically localized prostate cancer has been shown to improve survival in men with intermediate or high-risk disease. There is no high level evidence to support the superiority of radical prostatectomy, with or without adjuvant or salvage external beam radiotherapy in comparison to definitive radiotherapy with or without androgen deprivation, and the choice should be individualized. Read More

Prostate Cancer Prostatic Dis 2019 Mar 8. Epub 2019 Mar 8.

Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: The SPINK1 molecular subtype is more common in African-American (AA) men with prostatic adenocarcinoma (PCa) than European Americans (EA). Studies have suggested that SPINK1 expression is associated with more aggressive disease. However, the size, follow-up, and racial diversity of prior patient cohorts have limited our understanding of SPINK1 expression in AA men. Read More

J Nucl Med 2019 Mar 8. Epub 2019 Mar 8.

Eberhard Karls University Tübingen, Germany.

Biochemical recurrence (BCR) after prostate cancer surgery is very common, even after additional salvage radiotherapy (SRT). This might be explained by target miss. Improved diagnostic accuracy provided by PET could potentially circumvent this therapeutic gap. Read More

JAMA Netw Open 2019 Mar 1;2(3):e190442. Epub 2019 Mar 1.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, British Columbia, Canada.

Importance: Proper evaluation of the performance of artificial intelligence techniques in the analysis of digitized medical images is paramount for the adoption of such techniques by the medical community and regulatory agencies.

Objectives: To compare several cross-validation (CV) approaches to evaluate the performance of a classifier for automatic grading of prostate cancer in digitized histopathologic images and compare the performance of the classifier when trained using data from 1 expert and multiple experts.

Design, Setting, And Participants: This quality improvement study used tissue microarray data (333 cores) from 231 patients who underwent radical prostatectomy at the Vancouver General Hospital between June 27, 1997, and June 7, 2011. Read More

Eur Radiol 2019 Mar 7. Epub 2019 Mar 7.

Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Objectives: We sought to evaluate the correlation between MRI phenotypes of prostate cancer as defined by PI-RADS v2 and the Decipher Genomic Classifier (used to estimate the risk of early metastases).

Methods: This single-center, retrospective study included 72 nonconsecutive men with prostate cancer who underwent MRI before radical prostatectomy performed between April 2014 and August 2017 and whose MRI registered lesions were microdissected from radical prostatectomy specimens and then profiled using Decipher (89 lesions; 23 MRI invisible [PI-RADS v2 scores ≤ 2] and 66 MRI visible [PI-RADS v2 scores ≥ 3]). Linear regression analysis was used to assess clinicopathologic and MRI predictors of Decipher results; correlation coefficients (r) were used to quantify these associations. Read More

J Sex Med 2019 Mar;16(3):383-393

Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address:

Background: Previous studies have documented improvement in erectile function after bilateral cavernous nerve injury (BCNI) in rats with the use of pioglitazone. Our group determined this improvement to be mediated by the insulin-like growth factor-1 (IGF-1) pathway.

Aim: To eliminate the systemic effects of pioglitazone and evaluate the local delivery of IGF-1 by polymeric microspheres after BCNI in the rat. Read More

Aging Male 2019 Mar 7:1-6. Epub 2019 Mar 7.

d Center for science, Clinical cente of Montenegro , Podgorica , Montenegro.

We aimed to analyze the correlation of perineural invasion on transrectal ultrasound guided prostate biopsy with predictors of biochemical cancer recurrence, as well as its impact on clinical outcomes, for non-metastatic prostate cancer. For the study, patients with perineural invasion (N = 86) were recruited into group I and underwent open retropubic prostatectomy, regardless of clinical stage; cases with prostate cancer but without perineural invasion on biopsy, who received radical prostatectomy as the treatment modality, were placed into group II (n = 90). Perineural invasion was detected preoperatively in 43% of cases that revealed surgical margin positivity postoperatively, while 85% of the remaining cases (group II) had negative surgical margins. Read More

Anticancer Res 2019 Mar;39(3):1397-1401

Urology Unit, Cannizzaro Hospital, Catania, Italy.

Background/aim: To evaluate the diagnosis and management of prostate cancer (PCa) across twenty years of clinical practice.

Materials And Methods: From January 2000 to January 2019, 7,000 patients underwent transperineal prostate biopsy and 990 went through radical prostatectomy, respectively. The clinical and pathological stage in the presence of prostate cancer (PCa) are reported here. Read More

Int Urol Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Department of Urology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR, 72205, USA.

Purpose: To study regional trends in average years of potential life lost (AYPLL) among Caucasians (CA) and African Americans (AA) with prostate cancer (Pca) who received radical prostatectomy or radiation therapy among four different regions in the US as well as across different tumor grades. Years of potential life lost is defined as the difference between a predetermined end-point age and the age at death for a death that occurred prior to that end age, hence the AYPLL is calculated by dividing the total YPLL by the total number of patients died.

Methods: The surveillance epidemiology and end results (SEER) database was used to identify Pca patients who were CA or AA and who have received radical prostatectomy or radiation therapy. Read More

World J Urol 2019 Mar 6. Epub 2019 Mar 6.

Division of Urology, Department of Surgery, Woodstock General Hospital, Woodstock, ON, Canada.

Purpose: To describe a patient and procedure specific approach to selecting Venous thromboembolism (VTE) prophylaxis for men who undergo radical prostatectomy.

Methods: We performed a literature search and narrative review of VTE after radical prostatectomy. We describe the current paradigm of perioperative thromboprophylaxis and underlying rationale. Read More

Investig Clin Urol 2019 Mar 19;60(2):84-90. Epub 2019 Feb 19.

Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: To identify the association between tumor metabolism and prostate cancer (PCa), we investigated the relationship between expression of metabolism-related genes and clinicopathologic outcomes in patients with localized PCa.

Materials And Methods: We prospectively collected periprostatic adipose tissue from 40 PCa patients and extracted the RNA of each sample. After cDNA was synthesized from the extracted RNA, we analyzed the expression of 18 metabolism-related genes using real-time polymerase chain reaction. Read More

Am J Mens Health 2019 Mar-Apr;13(2):1557988319835326

1 Department of Clinical Pharmacy, University of California, San Francisco, CA, USA.

Prostate cancer (PCa) is the leading cancer in men in the United States. This study evaluated direct costs of treating urinary problems after PCa treatments and determined predictors of long-term costs for urinary problems. Data from the Cancer of Prostate Strategic Urologic Research Endeavor registry was analyzed for this study. Read More

Nucl Med Biol 2019 Jan 29;70:32-38. Epub 2019 Jan 29.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Introduction: Prostate cancer (PCa) often shows an overexpression of the gastrin-releasing peptide receptor (GRPr). Therefore, GRPr is a possible theragnostic target. An interesting antagonist GRPr-ligand is RM2 or BAY86-7548. Read More

Hinyokika Kiyo 2018 Dec;64(12):501-504

The Department of Urology, Kyoto City Hospital.

We report a 60-year-old man with prostate cancer diagnosed during androgen replacement therapy (ART) for late onset hypogonadism after surgery for pituitary adenoma. He was refered to the department of urology since prostate specific antigen values were elevated after 6 months of ART. After the diagnosis of prostate cancer, ART was discontinued, and robot-asssited laparoscopic radical prostatectomy with pelvic lymphadenoctomy was performed. Read More

World J Urol 2019 Mar 4. Epub 2019 Mar 4.

Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Purpose: Accurate life expectancy prediction is essential in decision-making concerning treatment of clinically localized prostate cancer (PCa). Nomogram predictions are more precise and reproducible than clinician's estimations. The most accurate nomogram addressing 10-year life expectancy in PCa patients has not been externally validated to date. Read More

Front Oncol 2019 15;9:71. Epub 2019 Feb 15.

Academic Department of Radiation Oncology, Centre Oscar Lambret, Lille, France.

To report the preliminary results of salvage re-irradiation in the prostatic bed after radical prostatectomy and salvage external beam radiation therapy (EBRT) using robotic stereotactic body radiation therapy (SBRT) with Cyberknife® for local recurrence of prostate cancer. Retrospective monocentric analysis was performed on patients treated with SBRT for isolated macroscopic recurrence in the prostatic bed. All patients had radical prostatectomy and salvage or adjuvant EBRT. Read More

World J Urol 2019 Mar 2. Epub 2019 Mar 2.

Department of Radiology, Centre Du Cancer and Institut de Recherche Expérimentale Et Clinique (IREC, IMAG), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200, Brussels, Belgium.

Purpose: It is generally accepted that when metastases develop in a patient with biochemical recurrence of prostate cancer (PCa), they follow a centrifuge pattern of seeding from the pelvis and that most patients enter the disease as oligometastatic. In this study, we used whole-body magnetic resonance imaging (WB-MRI) to assess the anatomical distribution of oligo- and polymetastatic disease and the impact of the initial treatment on this distribution in patients.

Materials And Methods: WB-MRI examinations of patients with a rising prostate-specific antigen (PSA) after radical treatment by surgery or/and radiotherapy were analyzed for disease recurrence. Read More

World J Urol 2019 Mar 2. Epub 2019 Mar 2.

Division of Urology, NorthShore University HealthSystem, Evanston, USA.

Purpose: Refractory urinary incontinence after channel transurethral resection of the prostate (cTURP) (TURP in the setting of prostate cancer) is a rare occurrence treated with artificial urinary sphincter (AUS). We sought to characterize those patients receiving AUS after cTURP and understand device longevity.

Materials And Methods: We identified patients who underwent cTURP and AUS placement in SEER-Medicare from 2002 to 2014. Read More

Eur Urol 2019 Feb 27. Epub 2019 Feb 27.

Department of Urology, University of Heidelberg, Heidelberg, Germany.

BJU Int 2019 Mar 2. Epub 2019 Mar 2.

Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY.

Objective: to investigate the genomic features of tertiary pattern 5 (TP5) on radical prostatectomy specimens in an effort to explain the poor clinical outcomes associated with this disease subtype.

Patients & Methods: Data from 159 men with Gleason Grade Group (GGG) 3 or 4 were considered. All patients had Decipher diagnostic testing with transcript profiles and SCAN-normalized expression of coding genes. Read More

Prostate 2019 Mar 2. Epub 2019 Mar 2.

The Key Laboratory of Experimental Teratology, Ministry of Education and Department of Pathology, Shandong University, School of Basic Medical Sciences, Jinan, China.

Objectives: The predictive value of the histological parameters and molecular markers for neoadjuvant hormonal therapy (NHT) in prostate cancer (PCa) has not been well established. The aim of this study is to determine pathological variables that can predict differences in response to NHT in PCa.

Methods: A total of 85 locally high risk PCa patients with matched preoperative needle biopsies and radical prostatectomy (RP) specimens were included. Read More

World J Urol 2019 Mar 1. Epub 2019 Mar 1.

Radiotherapy Department, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Purpose: The aim of this communication was to assess the efficacy of directed oligometastatic radiotherapy (RT) based on Ga-PSMA PET/CT in patients with prostate cancer (PCa) biochemical relapse (BCR) after primary treatment with curative intent.

Methods: This is a retrospective analysis of a monocentric cohort of PCa patients diagnosed with oligometastatic disease on Ga-PSMA PET/CT and treated with metastasis-directed RT. Inclusion criteria were: histologically proven PCa, BCR after primary treatment with curative intent, oligometastatic disease defined as ≤ 3 metastatic lesions. Read More

BMC Med Imaging 2019 Feb 28;19(1):22. Epub 2019 Feb 28.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Background: For most computer-aided diagnosis (CAD) problems involving prostate cancer detection via medical imaging data, the choice of classifier has been largely ad hoc, or been motivated by classifier comparison studies that have involved large synthetic datasets. More significantly, it is currently unknown how classifier choices and trends generalize across multiple institutions, due to heterogeneous acquisition and intensity characteristics (especially when considering MR imaging data). In this work, we empirically evaluate and compare a number of different classifiers and classifier ensembles in a multi-site setting, for voxel-wise detection of prostate cancer (PCa) using radiomic texture features derived from high-resolution in vivo T2-weighted (T2w) MRI. Read More

Int J Mol Sci 2019 Feb 27;20(5). Epub 2019 Feb 27.

Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.

This study aimed to validate whether 5-hydroxymethylcytosine (5hmC) level in combination with ERG expression is a predictive biomarker for biochemical failure (BF) in men undergoing radical prostatectomy (RP) for prostate cancer (PCa). The study included 592 PCa patients from two consecutive Danish RP cohorts. 5hmC level and ERG expression were analyzed using immunohistochemistry in RP specimens. Read More

Med Sci Monit 2019 Feb 28;25:1572-1581. Epub 2019 Feb 28.

Department of Urology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China (mainland).

BACKGROUND Prostate cancer (PCa), accounting for 28% of all male cancer cases, is the second leading cause of cancer-related death among men. NFATc1, belonging to the NFAT family, is overexpressed in PCa and is correlated with the risk of recurrence after radical prostatectomy. MATERIAL AND METHODS In the present study, the expression of NFATc, c-myc, and PKM2 in PCa cells was regulated by lentiviruses and then detected by real-time PCR and Western blot analysis. Read More