18,993 results match your criteria Prostate Cancer - Radical Retropubic Prostatectomy


The role of MRI/TRUS fusion biopsy in the diagnosis of clinically significant prostate cancer.

Ther Adv Urol 2020 Jan-Dec;12:1756287220916613. Epub 2020 May 18.

Department of Urology, ASST Rhodense, G. Salvini Hospital, Garbagnate, Milan, Italy.

Background: The aim of this work is to evaluate the detection rate of magnetic resonance imaging/transrectal ultrasound (MRI/TRUS) fusion-guided biopsy for clinically significant prostate cancers (Cs PCas), with particular interest in biopsy-naive patients and patients in active surveillance. MRI-targeted biopsy improves cancer detection rate (DR) in patients with prior negative biopsies; the current literature focuses on biopsy naive patients. We also evaluated the pathologic concordance between biopsies and surgical specimens. Read More

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http://dx.doi.org/10.1177/1756287220916613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238303PMC

Influence of previous laparo-endoscopic inguinal hernia repair on performing radical prostatectomy: a nationwide survey among urological surgeons.

Surg Endosc 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery/Hernia Clinic, Diakonessenhuis Utrecht/Zeist, Secretariaat Heelkunde, Professor Lorentzlaan 76, 3707 HL, Zeist, The Netherlands.

Background: There is considerable demographic overlap of inguinal hernia patients and prostate cancer patients. Previous laparo-endoscopic inguinal hernia mesh repairs can complicate subsequent radical prostatectomies due to adhesions and distortion of anatomic planes. This study aims to assess the experience of urological surgeons on the safety and feasibility of performing radical prostatectomies after laparo-endoscopic inguinal hernia mesh repair. Read More

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http://dx.doi.org/10.1007/s00464-020-07676-4DOI Listing

Epigenetic Analysis of Circulating Tumor DNA in Localized and Metastatic Prostate Cancer: Evaluation of Clinical Biomarker Potential.

Cells 2020 May 31;9(6). Epub 2020 May 31.

Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. (M.T.B.).

Novel and minimally-invasive prostate cancer (PCa)-specific biomarkers are needed to improve diagnosis and risk stratification. Here, we investigated the biomarker potential in localized and metastatic PCa (mPCa) of methylated circulating tumor DNA (ctDNA) in plasma. Using the Marmal-aid database and in-house datasets, we identified three top candidates specifically hypermethylated in PCa tissue: and (specificity/sensitivity: 80%-100%/75-94%). Read More

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http://dx.doi.org/10.3390/cells9061362DOI Listing

Immunohistochemical PSMA expression patterns of primary prostate cancer tissue are associated with the detection rate of biochemical recurrence with Ga-PSMA-11-PET.

Theranostics 2020 15;10(14):6082-6094. Epub 2020 May 15.

Department of Nuclear Medicine, University Hospital Zürich, University of Zürich, Zurich, Switzerland.

Prostate-specific membrane antigen (PSMA) targeted PET has a high detection rate for biochemical recurrence (BCR) of prostate cancer (PCa). Nevertheless, even at high prostate-specific antigen (PSA) levels (> 3 ng/ml), a relevant number of PSMA-PET scans are negative, mainly due to PSMA-negative PCa. Our objective was to investigate whether PSMA-expression patterns of the primary tumour on immunohistochemistry (IHC) are associated with PSMA-PET detection rate of recurrent PCa. Read More

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http://dx.doi.org/10.7150/thno.44584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255040PMC

Local staging of prostate cancer with multiparametric-MRI: accuracy and inter-reader agreement.

Med Pharm Rep 2020 Apr 22;93(2):150-161. Epub 2020 Apr 22.

Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background: The accuracy of prostate cancer local staging at the time of diagnosis directly influences patient prognosis and treatment.

Aim: To evaluate the diagnostic performance and interobserver variability of mp-MRI in local staging of prostate cancer, using the histopathologic findings at prostatectomy as the reference standard.

Methods: Fifty patients (mean age 64. Read More

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http://dx.doi.org/10.15386/mpr-1390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243891PMC

Survival outcomes of Asian younger men (< 55 years) undergoing radical prostatectomy: a review of prostate cancer database in a tertiary hospital in Singapore.

Int Urol Nephrol 2020 May 31. Epub 2020 May 31.

Department of Urology, Singapore General Hospital, Outram Rd, Singapore, 169608, Singapore.

Purpose: Prostate cancer largely affects older men. This study aims to investigate prostate cancer in younger men (< 55 years) to shed light on the survival outcomes of this unique subset of patients in Asian context.

Methods: Data were obtained from the Singapore General Hospital Prostate Cancer Registry. Read More

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http://dx.doi.org/10.1007/s11255-020-02518-7DOI Listing

Radical retropubic prostatectomy: Origins and evolution of the technique.

Authors:
F Herranz-Amo

Actas Urol Esp 2020 May 28. Epub 2020 May 28.

Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address:

Objective: Historical review of the origins and technical evolution of retropubic prostatectomy in prostate cancer.

Material And Method: Review of original articles on the design of retropubic prostatectomy techniques.

Results: The first prostatectomy could have been performed in the early 19th century. Read More

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http://dx.doi.org/10.1016/j.acuro.2020.03.003DOI Listing

Peri-prostatic adipose tissue measurements using MRI predict prostate cancer aggressiveness in men undergoing radical prostatectomy.

J Endocrinol Invest 2020 May 30. Epub 2020 May 30.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Middle Yan-Chang Rd., Jing-An District, Shanghai, 200072, China.

Objectives: To evaluate the effect of peri-prostatic adipose tissue (PPAT) measurements using preoperative MRI on the prediction of prostate cancer (PCa) aggressiveness in men undergoing radical prostatectomy (RP).

Methods: We performed a retrospective study on 179 consecutive patients receiving RP from June 2016 to October 2018. Clinical characteristics were collected. Read More

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http://dx.doi.org/10.1007/s40618-020-01294-6DOI Listing

Radical retropubic prostatectomy: Vesicourethral anastomosis.

Authors:
F Herranz-Amo

Actas Urol Esp 2020 May 27. Epub 2020 May 27.

Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address:

Objective: Historical review of the procedures and maneuvers described in the literature for the performance of vesicourethral anastomosis (VUA) after retropubic prostatectomy.

Material And Method: Review of the main original articles on the design of VUA maneuvers.

Results: Various techniques have been described to facilitate VUA, the most common being those with soft or hard catheters, or endoscopes. Read More

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http://dx.doi.org/10.1016/j.acuro.2020.02.004DOI Listing

Retzius-sparing robotic-assisted laparoscopic radical prostatectomy: racial considerations for 250 consecutive cases.

J Robot Surg 2020 May 29. Epub 2020 May 29.

Division of Urology, Department of Surgery, Section of Urology, Augusta University, 1120 15th Street, BA-8414, Augusta, GA, 30912-4050, USA.

Our objective is to report the functional and oncologic outcomes of a cohort of 250 consecutive prostate cancer patients undergoing a Retzius-sparing approach and to assess for racial differences in continence outcomes. This was a prospective, single-center, case series of 250 consecutive prostate cancer patients who underwent a Retzius-sparing robotic-assisted laparoscopic radical prostatectomy by a single surgeon between May 2015 and April 2019. Our primary objective was to report post-operative continence outcomes of patients undergoing this technique. Read More

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http://dx.doi.org/10.1007/s11701-020-01096-1DOI Listing

A pre-specified model based on four kallikrein markers in blood improves predictions of adverse pathology and biochemical recurrence after radical prostatectomy.

Br J Cancer 2020 May 29. Epub 2020 May 29.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: A pre-specified model based on four kallikrein markers in blood, commercially available as 4Kscore, predicts Gleason Grade (GG) 3 + 4 or higher prostate cancer on biopsy. However, sampling error and variation in pathology reporting may miss aggressive disease.

Methods: The 4Kscore was measured in cryopreserved blood from 2330 men obtained before prostatectomy at a single institution between 2002 and 2010. Read More

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http://dx.doi.org/10.1038/s41416-020-0914-7DOI Listing

External validation of the Briganti nomogram predicting lymph node invasion in patients with intermediate and high-risk prostate cancer diagnosed with magnetic resonance imaging-targeted and systematic biopsies: A European multicenter study.

Urol Oncol 2020 May 25. Epub 2020 May 25.

Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Brussels, Belgium.

Objective: To validate a nomogram predicting lymph node invasion (LNI) in prostate cancer patients undergoing radical prostatectomy taking into consideration multiparametric-magnetic resonance imaging (mp-MRI) parameters and targeted biopsies in a western European cohort.

Patients And Methods: A total of 473 men diagnosed by targeted biopsies, using software-based MRI-ultrasound image fusion system, and operated by radical prostatectomy with extended pelvic lymph node dissection across 11 Europeans centers between 2012 and 2019 were identified. Area under the curve of the receiver operator characteristic curve, calibration plot and decision curve analysis were used to evaluated the performance of the model. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.04.011DOI Listing

Genetic Analysis Reveals a Significant Contribution of to Prostate Cancer Progression in Taiwanese Men.

Cancers (Basel) 2020 May 25;12(5). Epub 2020 May 25.

Department of Pharmacy, China Medical University, Taichung 404, Taiwan.

The genes that influence prostate cancer progression remain largely unknown. Since the carboxylesterase gene family plays a crucial role in xenobiotic metabolism and lipid/cholesterol homeostasis, we hypothesize that genetic variants in carboxylesterase genes may influence clinical outcomes for prostate cancer patients. A total of 478 (36 genotyped and 442 imputed) single nucleotide polymorphisms (SNPs) in five genes of the carboxylesterase family were assessed in terms of their associations with biochemical recurrence (BCR)-free survival in 643 Taiwanese patients with prostate cancer who underwent radical prostatectomy. Read More

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http://dx.doi.org/10.3390/cancers12051346DOI Listing

F-Fluciclovine positron emission tomography in men with biochemical recurrence of prostate cancer after radical prostatectomy and planning to undergo salvage radiotherapy: Results from LOCATE.

Pract Radiat Oncol 2020 May 25. Epub 2020 May 25.

Departments of Radiology and Nuclear Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Purpose: Conventional imaging rarely localizes the site(s) of prostate cancer recurrence in patients undergoing evaluation for salvage radiotherapy (sRT) after radical prostatectomy (RP). XXX (NCTXXX) was a prospective multicenter study investigating the impact of F-fluciclovine positron emission tomography/computed tomography (PET/CT) on the management of patients with biochemical recurrence of prostate cancer after curative-intent radiation or RP and negative or equivocal conventional imaging. Our objective was to determine the impact of F-fluciclovine PET/CT on treatment decisions for men planning to undergo sRT for biochemical recurrence post-RP. Read More

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http://dx.doi.org/10.1016/j.prro.2020.05.007DOI Listing

The decline of FANCM immunohistochemical expression in prostate cancer stroma correlates with the grade group.

Pathol Int 2020 May 28. Epub 2020 May 28.

Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

Prostate adenocarcinoma (PCa) stromal markers have recently gained attention as complementary diagnostic tools. The DNA reparation complex protein FANCM has been shown to express in the normal prostate stroma and FANCM gene alterations to be associated with PCa susceptibility; this has led to the hypothesis that an insufficient level of FANCM expression may provide additional information for the evaluation of PCa. The study cohort comprised 60 radical prostatectomy specimens. Read More

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http://dx.doi.org/10.1111/pin.12953DOI Listing

Techniques and Outcomes of Salvage Robot-Assisted Radical Prostatectomy (sRARP).

Eur Urol 2020 May 24. Epub 2020 May 24.

Department of Urology, University College London Hospital. NHS Foundation Trust. London. UK.

Background: Salvage Robot-Assisted Radical Prostatectomy (sRARP) has been described as feasible treatment for the management of localised prostate cancer (PCa) recurrence after primary treatment. However, no large reports have published cancer and quality outcomes.

Objective: To report perioperative, functional and oncologic outcomes of sRARP in patients with localised PCa recurrence. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.05.003DOI Listing

Association between Basal Total Testosterone Levels and Prostate Cancer D'Amico Risk Classes.

Urol Int 2020 May 27:1-8. Epub 2020 May 27.

Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy,

Objective: To test the hypothesis that basal total testosterone (TT) serum levels are associated with the D'Amico risk classification at diagnosis of prostate cancer (PCA).

Materials And Methods: From November 2014 to March 2018, preoperative basal levels of TT and prostate-specific antigen (PSA) were measured in 601 consecutive PCA patients who were not under androgen deprivation therapy or undergoing prior prostate surgery. Patients were classified into low (reference group), intermediate, and high risk classes according to biopsy findings. Read More

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http://dx.doi.org/10.1159/000506525DOI Listing

Transperineal free-hand mpMRI fusion targeted biopsies under local anesthesia for Prostate Cancer Diagnosis: a multicenter prospective study of 1,014 cases.

BJU Int 2020 May 26. Epub 2020 May 26.

Department of Urology, San Giovanni Battista Hospital, Città della Salute e della Scienza and University of Turin, Turin, Italy.

Background: No large multicentre prospective studies ever addressed the outcomes of mpMRI targeted fusion transperineal biopsy (TPFBx) under local anesthesia (LA). The debate upon best biopsy modality is still open.

Patients And Methods: We prospectively screened for inclusion 1,327 men with a positive mpMRI undergoing TPFBx (targeted cores and systematic cores) under LA, at two tertiary referral institutions, from Sep2016 to May2019. Read More

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http://dx.doi.org/10.1111/bju.15121DOI Listing

Knockdown of FBP1 enhances radiosensitivity in prostate cancer cells by activating autophagy.

Neoplasma 2020 May 26. Epub 2020 May 26.

Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.

For patients with clinically early-stage localized prostate cancer, radiotherapy is another treatment that can achieve radical treatment in addition to radical prostatectomy. Despite this, there is still a large number of patients with prostate cancer who have a biochemical recurrence after undergoing radiotherapy, or even clinical recurrence, leading to treatment failure. Although the expression of the fructose-1,6-bisphosphatase-1 (FBP1) gene has been found to be absent in various tumors and is associated with a poor prognosis in tumor patients. Read More

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http://dx.doi.org/10.4149/neo_2020_190807N728DOI Listing

Treatment of the primary in metastatic prostate cancer.

Curr Opin Urol 2020 Jul;30(4):566-575

Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute.

Purpose Of Review: The standard treatment in metastatic prostate cancer (mPCa) is systemic, based on androgen deprivation therapy recommended in different forms, alone or combined with abiraterone acetate or docetaxel. The aim of this review is to synthesize the available data from literature regarding the optimal treatment of the primary in patients diagnosed with metastatic prostate cancer.

Recent Findings: Multimodal treatments offer the best chance for survival for these patients, but the optimal strategy lacks consensus. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000779DOI Listing

Transient renal dysfunction due to rhabdomyolysis after robot-assisted radical prostatectomy.

Int Urol Nephrol 2020 May 25. Epub 2020 May 25.

Department of Urology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

Purpose: The aim of the present study was to investigate whether renal dysfunction following rhabdomyolysis occurs after robot-assisted radical prostatectomy (RARP), and to investigate the factors related to rhabdomyolysis after RARP.

Methods: A total of 180 consecutive patients who underwent RARP at our institution were investigated. Rhabdomyolysis was defined as creatine kinase (CK) > 1050 IU/L after RARP. Read More

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http://dx.doi.org/10.1007/s11255-020-02500-3DOI Listing

Diagnostic value of retrospectively fused CuCl PET/MRI in biochemical relapse of prostate cancer: comparison with fused F-Choline PET/MRI, CuCl2 PET/CT, F-Choline PET/CT, and mpMRI.

Abdom Radiol (NY) 2020 May 25. Epub 2020 May 25.

Unit of Nuclear Medicine, Department of Diagnostic Imaging, E.O. Galliera Hospital, Genoa, Italy.

Purpose: To assess the diagnostic value of retrospectively fused PET/MRI by comparing the detection rates (DRs) of fused CuCl PET/MRI vs. fused F-Choline PET/MRI in patients with suspected prostatic cancer (PCa) recurrence. The secondary objective was to compare the DRs of fused PET/MRI vs. Read More

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http://dx.doi.org/10.1007/s00261-020-02591-7DOI Listing

PSMA-PET/CT-based Lymph Node Atlas for Prostate Cancer Patients Recurring After Primary Treatment: Clinical Implications for Salvage Radiation Therapy.

Eur Urol Oncol 2020 May 22. Epub 2020 May 22.

Department of Radiation Oncology, Technical University Munich (TUM), Munich, Germany; Department of Radiation Sciences (DRS), Institute of Radiation Medicine (IRM), Helmholtz Zentrum München, Munich, Germany; Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Munich, Germany.

Background: Many patients experience recurrence of prostate cancer after radical prostatectomy.

Objective: The aim of this study was to visually analyze typical patterns of lymph node (LN) involvement for prostate cancer (PC) patients with biochemical recurrence after radical prostatectomy and lymphadenectomy by creating a color-coded heat map using gallium-68 prostate-specific membrane antigen positron emission tomography (Ga-PSMA-PET) imaging. Further, we evaluated which LNs were covered by the Radiation Therapy Oncology Group (RTOG) clinical target volume (CTV) contouring guidelines. Read More

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http://dx.doi.org/10.1016/j.euo.2020.04.004DOI Listing

Peritoneal Flap in Robot-Assisted Radical Prostatectomy.

Dtsch Arztebl Int 2020 Apr;117(14):243-250

Department of Urology, University of Regensburg, Caritas St. Josef Medical Center, Regensburg, Germany; Department of Urology and Andrology, Hospital of St. John of God (Krankenhaus der Barmherzigen Brüder Wien), Vienna, Austria; Department of Urology and Andrology, Paracelsus Medical University Salzburg, Salzburg, Austria; Department of Urology, St. Elisabeth Hospital Straubing, Straubing, Germany; Department of Urology, Vivantes Humboldt Hospital Berlin, Berlin Germany; These two authors are co-first authors.

Background: Lymphocele is the most common complication arising after pelvic lymph node dissection (PLND) in the setting of robot-assisted radical prostatectomy (RARP). The only data available until now on the utility of a peritoneal flap to prevent lymphocele were retrospectively acquired.

Methods: A randomized, controlled, multi-center trial with blinded assessment of endpoints was carried out on 232 patients with prostate cancer who underwent RARP with PLND. Read More

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http://dx.doi.org/10.3238/arztebl.2020.0243DOI Listing

Magnetic resonance imaging of the prostate after focal therapy with high-intensity focused ultrasound.

Abdom Radiol (NY) 2020 May 23. Epub 2020 May 23.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, 10065, USA.

For clinically significant, locally confined prostate cancer, whole-gland radical prostatectomy and radiotherapy are established effective treatment strategies that, however, come at a cost of significant morbidity related to urinary and sexual side effects. The concept of risk stratification paired with a better understanding of prognostic factors has led to the development of alternative management options including active surveillance and focal therapy for appropriately selected patients with localized disease. High-intensity focused ultrasound (HIFU) is one such minimally invasive, image-guided treatment option for prostate cancer. Read More

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http://dx.doi.org/10.1007/s00261-020-02577-5DOI Listing

Significance of Paneth-cell-like differentiation in prostatic adenocarcinoma: A retrospective cohort study of 80 cases.

Hum Pathol 2020 May 20. Epub 2020 May 20.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Departments of Urology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

The grading and prognosis of prostatic adenocarcinoma with Paneth cell-like differentiation (PanEC) of the prostate is controversial with limited available data. We identified 80 cases, not previously published, of PanEC first identified on biopsy (n=69), transurethral resection (TURP)(n=1) and radical prostatectomy (RP) (n=10). Out of 69 biopsies, 22 did not have a grade assigned. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.05.003DOI Listing

Ga-PSMA PET/CT for primary NM staging of high-risk prostate cancer.

J Nucl Med 2020 May 22. Epub 2020 May 22.

Aarhus University Hospital, Denmark.

With the largest high-risk prostate cancer (PCa) cohort to date undergoing Ga-prostate-specific membrane antigen (PSMA) PET/CT primary staging, we aimed to 1) characterize the metastatic spread of PCa in relation to tumor Ga-PSMA-uptake and the D'Amico classification, and 2) compare Ga-PSMA PET/CT findings with radical prostatectomy (RP) with pelvic lymph node dissection (PLND) histopathology. A total of 691 consecutive newly diagnosed, biopsy-proven, treatment-naïve, D'Amico high-risk PCa patients primary staged by Ga-PSMA PET/CT were included. PSMA maximum standardized uptake value (SUV) and metastatic findings were compared to PSA level, International Society of Urologic Pathology (ISUP) grade, and clinical stage as traditional risk stratification parameters. Read More

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http://dx.doi.org/10.2967/jnumed.120.245605DOI Listing

Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial.

Eur Urol 2020 May 19. Epub 2020 May 19.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Direct high-quality evidence is lacking evaluating perioperative pharmacologic prophylaxis (PP) after radical prostatectomy (RP) to prevent venous thromboembolism (VTE) leading to significant practice variation.

Objective: To study the impact of in-hospital PP on symptomatic VTE incidence and adverse events after RP at 30 d, with the secondary objective of evaluating overall VTE in a screening subcohort.

Design, Setting, And Participants: A prospective, phase 4, single-center, randomized trial of men with prostate cancer undergoing open or robotic-assisted laparoscopic RP was conducted (July 2017-November 2018). Read More

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http://dx.doi.org/10.1016/j.eururo.2020.05.001DOI Listing

Early 3-month treatment with comprehensive physical therapy program restores continence in urinary incontinence patients after radical prostatectomy: A randomized controlled trial.

Neurourol Urodyn 2020 May 22. Epub 2020 May 22.

Department of Functional Biology and Health Sciences, Faculty of Physiotherapy, University of Vigo, Vigo, Spain.

Aims: The objective of this study is to ascertain whether an early three-month treatment with electrotherapy and biofeedback restores continence in urinary incontinence patients after radical prostatectomy (RP).

Methods: Design: The study performed a randomized, controlled trial of parallel and open groups. Configuration: Secondary care, urology department of a university hospital complex. Read More

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http://dx.doi.org/10.1002/nau.24389DOI Listing

What is lost not using pelvic floor muscles manometry in prostate cancer patients who underwent radical prostatectomy.

Neurourol Urodyn 2020 May 22. Epub 2020 May 22.

Clinic of Sport Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

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http://dx.doi.org/10.1002/nau.24400DOI Listing

Fatal prostate cancer incidence trends in the United States and England by race, stage, and treatment.

Br J Cancer 2020 May 20. Epub 2020 May 20.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, 20892, Bethesda, MD, USA.

Background: Differential uptake of prostate-specific antigen testing in the US and UK has been linked to between-country differences for prostate cancer incidence. We examined stage-specific fatal prostate cancer incidence trends in the US and England, by treatment and race/ethnicity.

Methods: Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program and Public Health England's National Cancer Registration and Analysis Service, we identified prostate cancer patients diagnosed between 1995 and 2005, aged 45-84 years. Read More

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http://dx.doi.org/10.1038/s41416-020-0859-xDOI Listing

Systematic review and meta-analysis of trials evaluating the role of adjuvant radiation after radical prostatectomy for prostate cancer: Implications for early salvage.

Can Urol Assoc J 2020 May 12. Epub 2020 May 12.

Division of Urology, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Introduction: Recent reports suggest that early salvage radiation (esRT) is non-inferior to adjuvant radiation (aRT) for adverse pathological features at radical prostatectomy. However, aRT was accepted as a standard treatment primarily based on effects on biochemical progression-free survival (bPFS). In order to understand the merits of esRT, the objective was to reassess if aRT vs. Read More

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http://dx.doi.org/10.5489/cuaj.6440DOI Listing

Microtubule-associated protein tau (MAPT) promotes bicalutamide resistance and is associated with survival in prostate cancer.

Urol Oncol 2020 May 16. Epub 2020 May 16.

Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Introduction: Microtubule-associated protein tau (MAPT), facilitates tubulin assembly and microtubule stabilization. Several studies have shown that overexpression of MAPT is linked to poor prognosis and is involved in taxane resistance in cancer. This study aimed to assess the expression and function of MAPT in prostate cancer (CaP). Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.04.032DOI Listing

Proteomic Tissue-Based Classifier for Early Prediction of Prostate Cancer Progression.

Cancers (Basel) 2020 May 17;12(5). Epub 2020 May 17.

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.

Although ~40% of screen-detected prostate cancers (PCa) are indolent, advanced-stage PCa is a lethal disease with 5-year survival rates around 29%. Identification of biomarkers for early detection of aggressive disease is a key challenge. Starting with 52 candidate biomarkers, selected from existing PCa genomics datasets and known PCa driver genes, we used targeted mass spectrometry to quantify proteins that significantly differed in primary tumors from PCa patients treated with radical prostatectomy (RP) across three study outcomes: (i) metastasis ≥1-year post-RP, (ii) biochemical recurrence ≥1-year post-RP, and (iii) no progression after ≥10 years post-RP. Read More

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http://dx.doi.org/10.3390/cancers12051268DOI Listing

Martini-Klinik experience on prostate cancer surgery during the early phase of COVID-19.

BJU Int 2020 May 18. Epub 2020 May 18.

Martini-Klinik Prostate Cancer Center Hamburg, Hamburg, Germany.

In order to restrain an uncontrolled spread of the 2019 Coronavirus-Disease (COVID-19) and to provide sufficient intensive-care unit (ICU) capacity, medical specializations needed to develop new routines and risk-strategy protocols. Those restrictions have also impacted the urologic community. Several medical organisations developed specific information-hubs, blogs and resource centers on how to tackle the COVID-19 situation (1-3). Read More

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http://dx.doi.org/10.1111/bju.15115DOI Listing

Techniques of robotic radical prostatectomy for the management of prostate cancer: which one, when and why.

Transl Androl Urol 2020 Apr;9(2):906-918

Department of Urology, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.

The advent of robotic assistance in surgery has completely revolutionized the surgical management of prostate cancer. It enables precise dissection and reconstruction in order to maximize oncological and functional outcomes. In many parts of the world, robot-assisted laparoscopic radical prostatectomy has evolved to become the surgical standard of care for localized disease, including in appropriately selected patients with high risk prostate cancer. Read More

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http://dx.doi.org/10.21037/tau.2019.09.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214982PMC

Single port robotic radical prostatectomy: a systematic review.

Transl Androl Urol 2020 Apr;9(2):898-905

Department of Urology, University of Illinois at Chicago, Chicago, IL, USA.

Several studies have assessed the safety and feasibility of single port robot-assisted radical prostatectomy using different and custom built robotic-assisted technology. In part due to the non-standardized nature of these approaches, single site robotic prostatectomy has not been widely adopted. With the recent approval of the da Vinci (Intuitive Surgical, Sunnyvale CA) Single Port (SP) platform, there has been a renewed interest in single site robotic-assisted prostatectomy and several institutions have begun reporting their initial experiences with this technique. Read More

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http://dx.doi.org/10.21037/tau.2019.11.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215004PMC

Anatomical robotic prostatectomy: technical factors to achieve superb continence and erectile function.

Transl Androl Urol 2020 Apr;9(2):887-897

Department of Urology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, USA.

Debate continues as to the superiority of robotic versus open radical prostatectomy for the surgical treatment of localized prostate cancer. Despite this controversy, retrospective data from high volume centres has demonstrated RARP is associated with improved pentafecta outcomes with lower transfusion rates, less incontinence, lower positive surgical margins and improved potency. Advocates of robotic assisted radical prostatectomy (RARP) believe an enhanced visual field, the precision afforded by robotic technology as well as lack of bleeding, sharp dissection and delicate tissue handling lead to improved outcomes. Read More

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http://dx.doi.org/10.21037/tau.2020.01.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214991PMC

Technical advancements in robotic prostatectomy: single-port extraperitoneal robotic-assisted radical prostatectomy and single-port transperineal robotic-assisted radical prostatectomy.

Transl Androl Urol 2020 Apr;9(2):848-855

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: To describe our step-by-step techniques for single-port robotic-assisted extraperitoneal and perineal radical prostatectomy as recent technical advancements in this field.

Methods: An English-language literature review was done using search terms including extraperitoneal, transperineal, single-port, robotic surgery, prostate cancer, radical prostatectomy in various combinations. Unique features of the da Vinci SP platform are discussed. Read More

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http://dx.doi.org/10.21037/tau.2019.11.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214976PMC

A case of castration-resistant prostate cancer with liver metastases achieved a complete response by docetaxel chemotherapy.

Transl Androl Urol 2020 Apr;9(2):819-823

Department of Uro-Oncology, Saitama Medical University International Medical Center, Saitama, Japan.

Castration-resistant prostate cancer (CRPC) patients with liver metastases have an extremely poor prognosis. Herein, we report a rare patient who achieved a complete response by docetaxel chemotherapy for this aggressive disease. A 67-year-old Japanese male diagnosed with local prostate cancer [initial prostate specific antigen (PSA) of 10. Read More

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http://dx.doi.org/10.21037/tau.2020.01.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215045PMC

Evolution of prostate cancer diagnosis: retrospective analysis of magnetic resonance imaging/ultrasound fusion guided biopsies protocol in routine practice and patients management.

Transl Androl Urol 2020 Apr;9(2):629-636

Department of Urology, Rouen University Hospital, Rouen, France.

Background: Magnetic resonance imaging (MRI) is today strongly recommended in prostate cancer (PCa) diagnosis. Therefore, MRI/ultrasound (MRI/US) fusion-guided biopsy is becoming the new standard patients management.

Methods: We report our experience during the last 4 years using this technique, with a protocol of 6 random cores (instead of the most used 12 cores protocol) associated to the target cores (2 to 3 per lesion). Read More

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http://dx.doi.org/10.21037/tau.2020.02.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215024PMC

Association of preoperative urethral parameters on magnetic resonance imaging and immediate recovery of continence following Retzius-sparing robot-assisted radical prostatectomy.

Transl Androl Urol 2020 Apr;9(2):501-509

Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.

Background: Studies regarding predictive factors of urinary continence following Retzius-sparing radical prostatectomy (RP) is limited. This study was designed to evaluate association of urethral parameters on preoperative magnetic resonance imaging (MRI) and immediate recovery of urinary continence following Retzius-sparing robot assisted radical prostatectomy (RS-RARP).

Methods: This retrospective cohort study enrolled 156 patients with clinically localized prostate cancer who underwent MRI before RS-RARP. Read More

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http://dx.doi.org/10.21037/tau.2019.12.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215013PMC

Predictive model using prostate MRI findings can predict candidates for nerve sparing radical prostatectomy among low-intermediate risk prostate cancer patients.

Transl Androl Urol 2020 Apr;9(2):437-444

Department of Urology, Peking University First Hospital, Beijing 100034, China.

Background: In order to improve postoperative functional outcome, including urinary continence and erectile function, nerve sparing surgery is recommended for patients with clinically localized prostate cancer (PCa). However, due to poor diagnosis accuracy at the preoperative stage, upstaging occurs in a considerable proportion of patients. Multiparametric magnetic resonance imaging (mpMRI) and the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) have recently shown excellent performance in diagnosis and staging of PCa. Read More

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http://dx.doi.org/10.21037/tau.2020.01.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215049PMC

Comparison of Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) and multi-parametric magnetic resonance imaging (MRI) in the evaluation of tumor extension of primary prostate cancer.

Transl Androl Urol 2020 Apr;9(2):382-390

Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China.

Background: To compare the diagnostic performance of Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-PSMA PET/CT) with multi-parametric magnetic resonance imaging (mpMRI) on extracapsular extension (ECE) and seminal vesicle invasion (SVI) in primary prostate cancer and its impact on therapeutic decisions.

Methods: We retrospectively enrolled 54 patients with both PET/CT and mpMRI before radical prostatectomy. Diagnostic performance of mpMRI, PET/CT and their combination (com-MRI/PET) on ECE and SVI on a patient basis were analyzed. Read More

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http://dx.doi.org/10.21037/tau.2020.03.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215027PMC

Radical prostatectomy versus brachytherapy for clinically localized prostate cancer on oncological and functional outcomes: a meta-analysis.

Transl Androl Urol 2020 Apr;9(2):332-343

Department of Urology Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Background: Prostate cancer (PCa) is a form of malignancy that harms the health status of elderly men worldwide. It is unclear which of radical prostatectomy (RP) or brachytherapy (BT) is the more effective treatment for PCa. This study presents the first highly comprehensive and up-to-date comparative analysis of the overall outcomes of RP versus BT. Read More

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http://dx.doi.org/10.21037/tau.2020.02.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215023PMC

Paraneoplastic remitting seronegative symmetrical synovitis with pitting edema (RS3PE), improved following surgical resection of prostatic carcinoma: A case report.

Urol Case Rep 2020 Sep 3;32:101232. Epub 2020 May 3.

National Cancer Center Hospital East, Chiba, Japan.

RS3PE syndrome is a rare condition that occurs in elderly individuals which can present alone or in association with various rheumatic or malignant diseases. We present a case of a 77-year-old man who was diagnosed with adenocarcinoma of the prostate and initially under active surveillance. 2 months after the diagnosis, he presented with arthralgia in both shoulders and knees, pitting edema of the both hands and feet. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217986PMC
September 2020

Pelvic Floor Muscle Training and Erectile Dysfunction in Radical Prostatectomy: A Randomized Controlled Trial Investigating a Non-Invasive Addition to Penile Rehabilitation.

Sex Med 2020 May 14. Epub 2020 May 14.

School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Crawley, Western Australia.

Introduction: Pelvic floor muscle (PFM) training for postprostatectomy incontinence is considered a first line approach to rehabilitation, but PFM training for erectile dysfunction (ED) after surgery is less well known. With more than 1.4 million new cases diagnosed globally per year, there is a need for non-invasive options to assist sexual dysfunction recovery. Read More

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http://dx.doi.org/10.1016/j.esxm.2020.03.005DOI Listing

Site-specific relapse patterns of patients with biochemical recurrence following radical prostatectomy assessed by Ga-PSMA-11 PET/CT or C-Choline PET/CT: impact of postoperative treatments.

World J Urol 2020 May 16. Epub 2020 May 16.

Department of Urology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: Salvage radiotherapy (RT) (± androgen deprivation therapy (ADT)) is often used as a treatment in patients with biochemical recurrence (BCR) following radical prostatectomy (RP). Unfortunately, even after RT ± ADT, a significant number of patients will develop 'second' BCR. The aim of this study was to investigate the impact of postoperative treatments (adjuvant/salvage radiotherapy (RT) ± androgen deprivation therapy) on the recurrence pattern in patients with BCR following RP assessed by 11C-Choline PET/CT or 68 Ga-PSMA PET/CT. Read More

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http://dx.doi.org/10.1007/s00345-020-03220-0DOI Listing

Outcomes of Salvage Radical Prostatectomy for M0 Castration-resistant Recurrent Prostate Cancer: A Reasonable Option in the Era of New Antiandrogen Therapies?

Eur Urol Focus 2020 May 12. Epub 2020 May 12.

Department of Urology, San Giovanni Battista Hospital, Città della Salute e della Scienza, University of Turin, Turin, Italy.

There is little evidence regarding salvage radical prostatectomy (sRP) for M0 castration-resistant prostate cancer (CRPC). We reviewed oncological results and complications for 23 men with radiographically recurrent M0 CRPC undergoing sRP at six institutions. Sixteen and ten men experienced at least one and one major (Clavien >2) complication, respectively. Read More

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http://dx.doi.org/10.1016/j.euf.2020.04.005DOI Listing