17,644 results match your criteria Prostate Cancer - Radical Retropubic Prostatectomy


Prospective comparison of whole-body MRI and Ga-PSMA PET/CT for the detection of biochemical recurrence of prostate cancer after radical prostatectomy.

Eur J Nucl Med Mol Imaging 2019 Mar 16. Epub 2019 Mar 16.

Department of Nuclear Medicine, University Dusseldorf, Medical Faculty, 40225, Dusseldorf, Germany.

Purpose: To assess whole-body magnetic resonance imaging (wb-MRI) for detection of biochemical recurrence in comparison to Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-PSMA PET/CT) in prostate cancer (Pca) patients after radical prostatectomy.

Methods: This was a prospective trial including 28 consecutive patients (mean age 65.3 ± 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00259-019-04308-5DOI Listing

Oncological control in high-risk prostate cancer after radical prostatectomy and salvage radiotherapy compared to radiotherapy plus primary hormone therapy.

Actas Urol Esp 2019 Mar 13. Epub 2019 Mar 13.

Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Introduction: In patients with high-risk localized prostate cancer (HRPCa), multimodal treatment plays a fundamental role.

Objective: To compare relapse-free survival (RFS) in patients with HRPCa, treated primarily with radiotherapy (RT)+hormone therapy (HT) versus radical prostatectomy (RP) and salvage RT (sRT)±HT when biochemical recurrence (BCR) appears.

Material And Methods: Retrospective analysis of 226 patients with HRPCa (1996-2008), treated primarily with RT+HT (n=137) or RP (n=89). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.acuro.2018.07.007DOI Listing

Perplexity of penile rehabilitation following radical prostatectomy.

Turk J Urol 2019 Jan 22;45(2):77-82. Epub 2019 Jan 22.

Department of Surgery, Division of Urology, University of Texas Health Science Center- McGovern Medical School at Houston, Houston, Texas, USA.

Radical prostatectomy has significantly improved prostate cancer survival rates but continues to have a negative impact on the patient's erectile function (EF). In attempts to improve erectile dysfunction (ED), clinicians have incorporated different treatment modalities to restore EF. Penile rehabilitation consists of understanding the mechanisms that affect post-prostatectomy EF and utilizing pharmacologic agents, devices, and interventions to promote the male sexual function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/tud.2019.18488DOI Listing
January 2019

Pfilates and Hypopressives for the Treatment of Urinary Incontinence after Radical Prostatectomy: Results of a Feasibility Randomized Controlled Trial.

PM R 2019 Mar 14. Epub 2019 Mar 14.

Faculty of kinesiology and Physical Education, University of Toronto, Toronto, Ontario.

Background: Urinary incontinence (UI) is an important side effect of radical prostatectomy (RP). Co-activation of surrounding muscles via novel techniques for pelvic floor rehabilitation known as Pfilates and Hypopressives have not been compared to pelvic floor muscle exercises (PFMX) for UI.

Objective: To assess the feasibility and efficacy of isolated PFMX with and without the addition of Pfilates and Hypopressives on UI recovery following RP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmrj.12157DOI Listing

Disease Control With Delayed Salvage Radiotherapy for Macroscopic Local Recurrence Following Radical Prostatectomy.

Front Oncol 2019 28;9:12. Epub 2019 Feb 28.

Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

To retrospectively assess clinical outcomes and toxicity profile of prostate cancer patients treated with delayed dose-escalated image-guided salvage radiotherapy (SRT) for macroscopic local recurrence after radical prostatectomy (RP). We report on a cohort of 69 consecutive patients with local recurrence after RP and no evidence of regional or distant metastasis who were referred for salvage radiotherapy between 2007 and 2016. SRT consisted of 64-66 Gy (2 Gy/fraction) to the prostatic bed followed by dose escalation to 72-74 Gy (2Gy/fraction) to the macroscopic disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403145PMC
February 2019

The impact of warmed and humidified CO insufflation during robotic radical prostatectomy: Results of a randomized controlled trial.

Urologia 2019 Mar 14:391560319834837. Epub 2019 Mar 14.

5 Department of Anaesthesiology, Hautepierre University Hospital, Strasbourg, France.

Background:: Cool and dry gas insufflation during laparoscopy induces hypothermia and cytokine increase, with significant perioperative morbidity. Our aim was to assess if warmed and humidified CO insufflation with HumiGard™ device can achieve significant benefits over standard insufflation in terms of risk of hypothermia, cytokine response, blood gases, and intra- and postoperative parameters, in the setting of robot-assisted radical prostatectomy (RARP).

Methods:: This was a prospective, randomized controlled clinical trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0391560319834837DOI Listing

Macroscopic locoregional relapse from prostate cancer: which role for salvage radiotherapy?

Clin Transl Oncol 2019 Mar 13. Epub 2019 Mar 13.

Radiotherapy Unit, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy.

Introduction: Salvage radiotherapy (SRT) after radical prostatectomy for prostate cancer (PCa) is recommended as soon as PSA rises above 0.20 ng/ml, but many patients (pts) still experience local macroscopic relapse. The aim of this multicentric retrospective analysis was to evaluate the role of SRT in pts with macroscopic relapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12094-019-02084-0DOI Listing

Aberrant , , and Hypermethylation has Potential as a Prognostic Biomarker for Prostate Cancer.

Int J Mol Sci 2019 Mar 7;20(5). Epub 2019 Mar 7.

Department of Molecular Medicine (MOMA), Aarhus University Hospital (AUH), Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

Prostate cancer (PCa) is a clinically heterogeneous disease and currently, accurate diagnostic and prognostic molecular biomarkers are lacking. This study aimed to identify novel DNA hypermethylation markers for PCa with future potential for blood-based testing. Accordingly, to search for genes specifically hypermethylated in PCa tissue samples and not in blood cells or other cancer tissue types, we performed a systematic analysis of genome-wide DNA methylation data (Infinium 450K array) available in the Marmal-aid database for 4072 malignant/normal tissue samples of various types. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20051173DOI Listing

Factors related to self-rated health and life satisfaction one year after radical prostatectomy for localised prostate cancer: a cross-sectional survey.

Scand J Caring Sci 2019 Mar 13. Epub 2019 Mar 13.

Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.

Background: Localised prostate cancer affects patient's quality of life in many ways. The aim of this study was to explore factors related to self-rated health and life satisfaction for patients treated for prostate cancer, and to compare the results of these generic quality-of-life measures to the prostate cancer-specific quality-of-life measure (UCLA Prostate Cancer Index), which focuses on physical functioning.

Material And Methods: This cross-sectional survey was carried out among 183 men who underwent radical prostatectomy in 2012-2015 at a university hospital in Finland and were seen 1 year postsurgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/scs.12664DOI Listing

Radical Surgery or Watchful Waiting in Prostate Cancer. Reply.

N Engl J Med 2019 03;380(11):1084

Regional Cancer Center Uppsala-Orebro, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1900410DOI Listing

Radical Surgery or Watchful Waiting in Prostate Cancer.

Authors:
N David Charkes

N Engl J Med 2019 03;380(11):1084

Temple University Hospital, Philadelphia, PA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1900410DOI Listing
March 2019
1 Read

Radical Surgery or Watchful Waiting in Prostate Cancer.

N Engl J Med 2019 03;380(11):1083-1084

University of Hong Kong, Hong Kong, China

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1900410DOI Listing

Essential Updates in Grading, Morphotyping, Reporting, and Staging of Prostate Carcinoma for General Surgical Pathologists.

Arch Pathol Lab Med 2019 Mar 13. Epub 2019 Mar 13.

From the Departments of Pathology (Drs Paner and Choy) and Surgery (Urology) (Dr Paner), University of Chicago, Chicago, Illinois; and the Departments of Pathology and Laboratory Medicine (Drs Gandhi and Amin) and Urology (Dr Amin), University of Tennessee Health Science Center, Memphis.

Context.—: Within this decade, several important updates in prostate cancer have been presented through expert international consensus conferences and influential publications of tumor classification and staging.

Objective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5858/arpa.2018-0334-RADOI Listing

On the feasibility of transperineal 3D ultrasound image guidance for robotic radical prostatectomy.

Int J Comput Assist Radiol Surg 2019 Mar 13. Epub 2019 Mar 13.

Department of Electrical and Computer Engineering, University of British Columbia, 2332 Main Mall, Vancouver, BC, V6T 1Z4, Canada.

Purpose: Prostate cancer is the most prevalent form of male-specific cancers. Robot-assisted laparoscopic radical prostatectomy (RALRP) using the da Vinci surgical robot has become the gold-standard treatment for organ-confined prostate cancer. To improve intraoperative visualization of anatomical structures, many groups have developed techniques integrating transrectal ultrasound (TRUS) into the surgical workflow. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11548-019-01938-w
Publisher Site
http://dx.doi.org/10.1007/s11548-019-01938-wDOI Listing
March 2019
1 Read

[Impact of diverse shapes of prostatic apex on positive apical margin rate and biochemical recurrence following laparoscopic radical prostatectomy].

Zhonghua Wai Ke Za Zhi 2019 Mar;57(3):200-205

Department of Urology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.

To explore the effects of various forms of prostatic apex on positive apical margin rate (PAM) and biochemical recurrence (BCR) after laparoscopic radical prostatectomy. A retrospective analysis of 309 patients (aging (65±6) years) who were experienced laparoscopic radical prostatectomy from January 2010 to December 2016 at the Department of Urology, First Affiliated Hospital of Fujian Medical University. According to the relationship between prostate apex and membrane urethra at the mid-sagittal plane of preoperative MRI, all patients were classified into 4 categories. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.03.008DOI Listing
March 2019
1 Read

Reply to Effectiveness of radical prostatectomy with adjuvant radiotherapy versus radiotherapy plus androgen deprivation therapy for men with advanced prostate cancer: Do we have certainties today?

Cancer 2019 Mar 12. Epub 2019 Mar 12.

Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.32054DOI Listing

Effectiveness of radical prostatectomy with adjuvant radiotherapy versus radiotherapy plus androgen deprivation therapy for men with advanced prostate cancer: Do we have certainties today?

Authors:
Luigi De Cicco

Cancer 2019 Mar 12. Epub 2019 Mar 12.

Department of Radiation Oncology, Azienda Socio Sanitaria Territoriale (ASST) della Valle Olona, Varese, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.32055DOI Listing

Downregulation of serum CXCL4L1 predicts progression and poor prognosis in prostate cancer patients treated by radical prostatectomy.

Asian J Androl 2019 Mar 12. Epub 2019 Mar 12.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Our previous study found that plate factor-4 variant (CXCL4L1) was downregulated in the serum of patients with prostate cancer (PCa). The aim of the present study was to investigate the prognostic value of CXCL4L1 in PCa. In total, 213 PCa patients treated with radical prostatectomy were enrolled and peripheral blood samples of all patients were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aja.aja_117_18DOI Listing
March 2019
1 Read

Gleason Score Correlation Between Prostate Needle Biopsy and Radical Prostatectomy Materials.

Turk Patoloji Derg 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, Cizre Dr. Selahattin Cizrelioğlu State Hospital, ŞIRNAK, TURKEY.

Objective: Prostate cancer is the second most common cancer in men. Digital rectal examination, transrectal ultrasonography and serum prostate specific antigen represents a diagnostic triad for the detection of prostatic carcinoma. About 50 years ago, Dr. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5146/tjpath.2018.01453DOI Listing

[Current controversies in the treatment of localized prostate cancer].

Urologe A 2019 Mar 11. Epub 2019 Mar 11.

Urologische Klinik und Poliklinik, Klinikum der Universität München, Marchioninistraße 15, 81377, München, Deutschland.

In the prostate-specific antigen (PSA) era, most prostate cancers (PCa) are diagnosed in a localized stage and a plethora of therapeutic options are warranted in different clinical settings and disease stages of localized PCa. In the current narrative review, we give an overview of the current controversies in the therapeutic landscape of localized PCa and focus on organ-sparing approaches, percutaneous radiotherapy, brachytherapy as well as retropubic and robot-assisted prostatectomy by summarizing studies that have been published within the last two years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00120-019-0903-8DOI Listing

Impact of the estimated blood loss during radical prostatectomy on functional outcomes.

Urol Oncol 2019 Mar 8. Epub 2019 Mar 8.

Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Objective: To investigate the effect of the estimated blood loss (BL) during radical prostatectomy (RP) for prostate cancer (CaP) on functional outcomes. We hypothesized that the estimated BL during RP for clinically localized CaP does not affect the functional outcomes.

Materials And Methods: Patients who underwent open RP (ORP) or robotic-assisted laparoscopic RP (RALP) were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2019.01.006DOI Listing

High-risk prostate cancer. Optimal treatment. New evidences.

Arch Esp Urol 2019 03;72(2):203-210

Department of Urology. Hospital Universitario La Paz. Madrid. Spain. Instituto de Investigación Hospital Universitario La Paz (IdiPAZ). Madrid. Spain. Universidad Autónoma de Madrid. Madrid. Spain.

There are multiple definitions of high risk prostate cancer and each definition is associated with a different prognosis. Men classified as having high-risk disease warrant treatment because durable outcomes can be achieved. Radical prostatectomy, radiation therapy and androgen deprivation therapy play pivotal roles in the management of men with high-risk disease, and potentially in men with metastatic disease. Read More

View Article

Download full-text PDF

Source
March 2019
2 Reads

Management of positive lymph nodes following radical prostatectomy.

Arch Esp Urol 2019 03;72(2):182-191

Department of Urology and Robot-assisted and Reconstructive Surgical Urology. University of Cologne. Cologne. Germany.

Oligometastatic prostate cancer (PCA) has increasingly been detected in the era of modern imaging studies such as choline-specific and prostate-specific membrane antigen (PSMA)-positron emission tomography and X-ray computed tomography (PET/CT). Recent evidence suggests that durable control is attainable with local treatment modalities such as salvage metastasectomy or stereotactic radiation therapy targeting oligometastases, either with or without the use of systemic therapy.The purpose of this article is to critically review the current findings on the indication, extent, and oncologic outcome of salvage lymphadenectomy (SLND). Read More

View Article

Download full-text PDF

Source

Current concepts in oligometastatic prostate cancer: Is there a role for radical prostatectomy?

Arch Esp Urol 2019 03;72(2):174-181

University College London Hospital. NHS Foundation Trust. London. UK. Nuffield Department of Surgical Sciences. University of Oxford. Oxford. UK.

Introduction: Prostate cancer is the most common solid organ malignancy in men. Despite the implementation of PSA screening, the incidence of metastatic prostate cancer in Spain is still around 4%. In this clinical scenario, systemic treatment is the gold standard. Read More

View Article

Download full-text PDF

Source

A case of synchronous advanced gastric cancer and locally advanced prostate cancer with combined laparoscopic and robotic surgery: A case report.

Int J Surg Case Rep 2019 Mar 1;56:82-85. Epub 2019 Mar 1.

Department of Urology, Nagoya Tokushukai General Hospital, Kasugai City, Japan.

Introduction: The optimal management strategy for synchronous gastric cancer (GC) and prostate cancer (PCa) remains unclear, particularly in cases in which two cancers are progressive.

Presentation Of Case: A 68-year-old man diagnosed with synchronous advanced GC and locally advanced PCa was referred to our institution. Laparoscopic total gastrectomy (LTG) and robotic-assisted radical prostatectomy were simultaneously performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2019.02.032DOI Listing

Evolution of definitive external beam radiation therapy in the treatment of prostate cancer.

Authors:
Tiffany Daly

World J Urol 2019 Mar 8. Epub 2019 Mar 8.

Radiation Oncology Princess Alexandra Raymond Terrace (ROPART), 31 Raymond Terrace, South Brisbane, QLD, Australia.

Purpose: Although the clinical significance of a diagnosis of prostate cancer for some men is debated, for many men it leads to significant morbidity and mortality. Radical treatment of clinically localized prostate cancer has been shown to improve survival in men with intermediate or high-risk disease. There is no high level evidence to support the superiority of radical prostatectomy, with or without adjuvant or salvage external beam radiotherapy in comparison to definitive radiotherapy with or without androgen deprivation, and the choice should be individualized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02661-6DOI Listing
March 2019
1 Read

SPINK1 expression is enriched in African American prostate cancer but is not associated with altered immune infiltration or oncologic outcomes post-prostatectomy.

Prostate Cancer Prostatic Dis 2019 Mar 8. Epub 2019 Mar 8.

Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: The SPINK1 molecular subtype is more common in African-American (AA) men with prostatic adenocarcinoma (PCa) than European Americans (EA). Studies have suggested that SPINK1 expression is associated with more aggressive disease. However, the size, follow-up, and racial diversity of prior patient cohorts have limited our understanding of SPINK1 expression in AA men. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41391-019-0139-0DOI Listing

Intention to treat analysis of Ga-PSMA and C-choline PET/CT versus CT for prostate cancer recurrences after surgery.

J Nucl Med 2019 Mar 8. Epub 2019 Mar 8.

Eberhard Karls University Tübingen, Germany.

Biochemical recurrence (BCR) after prostate cancer surgery is very common, even after additional salvage radiotherapy (SRT). This might be explained by target miss. Improved diagnostic accuracy provided by PET could potentially circumvent this therapeutic gap. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.118.224543DOI Listing
March 2019
1 Read

Comparison of Artificial Intelligence Techniques to Evaluate Performance of a Classifier for Automatic Grading of Prostate Cancer From Digitized Histopathologic Images.

JAMA Netw Open 2019 Mar 1;2(3):e190442. Epub 2019 Mar 1.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, British Columbia, Canada.

Importance: Proper evaluation of the performance of artificial intelligence techniques in the analysis of digitized medical images is paramount for the adoption of such techniques by the medical community and regulatory agencies.

Objectives: To compare several cross-validation (CV) approaches to evaluate the performance of a classifier for automatic grading of prostate cancer in digitized histopathologic images and compare the performance of the classifier when trained using data from 1 expert and multiple experts.

Design, Setting, And Participants: This quality improvement study used tissue microarray data (333 cores) from 231 patients who underwent radical prostatectomy at the Vancouver General Hospital between June 27, 1997, and June 7, 2011. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2019.0442DOI Listing

Correlation between MRI phenotypes and a genomic classifier of prostate cancer: preliminary findings.

Eur Radiol 2019 Mar 7. Epub 2019 Mar 7.

Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Objectives: We sought to evaluate the correlation between MRI phenotypes of prostate cancer as defined by PI-RADS v2 and the Decipher Genomic Classifier (used to estimate the risk of early metastases).

Methods: This single-center, retrospective study included 72 nonconsecutive men with prostate cancer who underwent MRI before radical prostatectomy performed between April 2014 and August 2017 and whose MRI registered lesions were microdissected from radical prostatectomy specimens and then profiled using Decipher (89 lesions; 23 MRI invisible [PI-RADS v2 scores ≤ 2] and 66 MRI visible [PI-RADS v2 scores ≥ 3]). Linear regression analysis was used to assess clinicopathologic and MRI predictors of Decipher results; correlation coefficients (r) were used to quantify these associations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06114-xDOI Listing
March 2019
1 Read

Insulin-Like Growth Factor-1-Loaded Polymeric Poly(Lactic-Co-Glycolic) Acid Microspheres Improved Erectile Function in a Rat Model of Bilateral Cavernous Nerve Injury.

J Sex Med 2019 Mar;16(3):383-393

Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address:

Background: Previous studies have documented improvement in erectile function after bilateral cavernous nerve injury (BCNI) in rats with the use of pioglitazone. Our group determined this improvement to be mediated by the insulin-like growth factor-1 (IGF-1) pathway.

Aim: To eliminate the systemic effects of pioglitazone and evaluate the local delivery of IGF-1 by polymeric microspheres after BCNI in the rat. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2018.12.018DOI Listing
March 2019
1 Read

Perineural invasion on biopsy specimen as predictor of tumor progression in aging male treated with radical prostatectomy. Could we use it for pre-surgical screening?

Aging Male 2019 Mar 7:1-6. Epub 2019 Mar 7.

d Center for science, Clinical cente of Montenegro , Podgorica , Montenegro.

We aimed to analyze the correlation of perineural invasion on transrectal ultrasound guided prostate biopsy with predictors of biochemical cancer recurrence, as well as its impact on clinical outcomes, for non-metastatic prostate cancer. For the study, patients with perineural invasion (N = 86) were recruited into group I and underwent open retropubic prostatectomy, regardless of clinical stage; cases with prostate cancer but without perineural invasion on biopsy, who received radical prostatectomy as the treatment modality, were placed into group II (n = 90). Perineural invasion was detected preoperatively in 43% of cases that revealed surgical margin positivity postoperatively, while 85% of the remaining cases (group II) had negative surgical margins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13685538.2019.1581758DOI Listing
March 2019
3 Reads

Prostate Cancer Diagnosis and Management Across Twenty Years of Clinical Practice: A Single-center Experience on 2,500 Cases.

Anticancer Res 2019 Mar;39(3):1397-1401

Urology Unit, Cannizzaro Hospital, Catania, Italy.

Background/aim: To evaluate the diagnosis and management of prostate cancer (PCa) across twenty years of clinical practice.

Materials And Methods: From January 2000 to January 2019, 7,000 patients underwent transperineal prostate biopsy and 990 went through radical prostatectomy, respectively. The clinical and pathological stage in the presence of prostate cancer (PCa) are reported here. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13254DOI Listing
March 2019
1 Read

Regional trends in average years of potential life lost (AYPLL) secondary to prostate cancer deaths among Caucasians and African Americans treated by surgery or radiation.

Int Urol Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Department of Urology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR, 72205, USA.

Purpose: To study regional trends in average years of potential life lost (AYPLL) among Caucasians (CA) and African Americans (AA) with prostate cancer (Pca) who received radical prostatectomy or radiation therapy among four different regions in the US as well as across different tumor grades. Years of potential life lost is defined as the difference between a predetermined end-point age and the age at death for a death that occurred prior to that end age, hence the AYPLL is calculated by dividing the total YPLL by the total number of patients died.

Methods: The surveillance epidemiology and end results (SEER) database was used to identify Pca patients who were CA or AA and who have received radical prostatectomy or radiation therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02116-2DOI Listing
March 2019
1 Read
1.293 Impact Factor

Perioperative venous thromboembolism prophylaxis in prostate cancer surgery.

World J Urol 2019 Mar 6. Epub 2019 Mar 6.

Division of Urology, Department of Surgery, Woodstock General Hospital, Woodstock, ON, Canada.

Purpose: To describe a patient and procedure specific approach to selecting Venous thromboembolism (VTE) prophylaxis for men who undergo radical prostatectomy.

Methods: We performed a literature search and narrative review of VTE after radical prostatectomy. We describe the current paradigm of perioperative thromboprophylaxis and underlying rationale. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02705-xDOI Listing
March 2019
1 Read

CRTC2 as a novel prognostic biomarker for worse pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with prostate cancer.

Investig Clin Urol 2019 Mar 19;60(2):84-90. Epub 2019 Feb 19.

Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: To identify the association between tumor metabolism and prostate cancer (PCa), we investigated the relationship between expression of metabolism-related genes and clinicopathologic outcomes in patients with localized PCa.

Materials And Methods: We prospectively collected periprostatic adipose tissue from 40 PCa patients and extracted the RNA of each sample. After cDNA was synthesized from the extracted RNA, we analyzed the expression of 18 metabolism-related genes using real-time polymerase chain reaction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4111/icu.2019.60.2.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397930PMC

Longitudinal Comparison of Patient-Level Outcomes and Costs Across Prostate Cancer Treatments With Urinary Problems.

Am J Mens Health 2019 Mar-Apr;13(2):1557988319835326

1 Department of Clinical Pharmacy, University of California, San Francisco, CA, USA.

Prostate cancer (PCa) is the leading cancer in men in the United States. This study evaluated direct costs of treating urinary problems after PCa treatments and determined predictors of long-term costs for urinary problems. Data from the Cancer of Prostate Strategic Urologic Research Endeavor registry was analyzed for this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1557988319835326DOI Listing
March 2019
1 Read

Accuracy of [Ga]Ga-RM2-PET/CT for diagnosis of primary prostate cancer compared to histopathology.

Nucl Med Biol 2019 Jan 29;70:32-38. Epub 2019 Jan 29.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Introduction: Prostate cancer (PCa) often shows an overexpression of the gastrin-releasing peptide receptor (GRPr). Therefore, GRPr is a possible theragnostic target. An interesting antagonist GRPr-ligand is RM2 or BAY86-7548. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nucmedbio.2019.01.009DOI Listing
January 2019

[Prostate Cancer Diagnosed during Androgen Replacement Therapy for Late-Onset Hypogonadism Treatment: A Case Report].

Hinyokika Kiyo 2018 Dec;64(12):501-504

The Department of Urology, Kyoto City Hospital.

We report a 60-year-old man with prostate cancer diagnosed during androgen replacement therapy (ART) for late onset hypogonadism after surgery for pituitary adenoma. He was refered to the department of urology since prostate specific antigen values were elevated after 6 months of ART. After the diagnosis of prostate cancer, ART was discontinued, and robot-asssited laparoscopic radical prostatectomy with pelvic lymphadenoctomy was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14989/ActaUrolJap_64_12_501DOI Listing
December 2018

External validation of a nomogram for the prediction of 10-year life expectancy in candidates for radical prostatectomy.

World J Urol 2019 Mar 4. Epub 2019 Mar 4.

Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Purpose: Accurate life expectancy prediction is essential in decision-making concerning treatment of clinically localized prostate cancer (PCa). Nomogram predictions are more precise and reproducible than clinician's estimations. The most accurate nomogram addressing 10-year life expectancy in PCa patients has not been externally validated to date. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02706-wDOI Listing

Stereotactic Re-irradiation for Local Recurrence in the Prostatic Bed After Prostatectomy: Preliminary Results.

Front Oncol 2019 15;9:71. Epub 2019 Feb 15.

Academic Department of Radiation Oncology, Centre Oscar Lambret, Lille, France.

To report the preliminary results of salvage re-irradiation in the prostatic bed after radical prostatectomy and salvage external beam radiation therapy (EBRT) using robotic stereotactic body radiation therapy (SBRT) with Cyberknife® for local recurrence of prostate cancer. Retrospective monocentric analysis was performed on patients treated with SBRT for isolated macroscopic recurrence in the prostatic bed. All patients had radical prostatectomy and salvage or adjuvant EBRT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2019.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384250PMC
February 2019
1 Read

Pattern of metastatic deposit in recurrent prostate cancer: a whole-body MRI-based assessment of lesion distribution and effect of primary treatment.

World J Urol 2019 Mar 2. Epub 2019 Mar 2.

Department of Radiology, Centre Du Cancer and Institut de Recherche Expérimentale Et Clinique (IREC, IMAG), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200, Brussels, Belgium.

Purpose: It is generally accepted that when metastases develop in a patient with biochemical recurrence of prostate cancer (PCa), they follow a centrifuge pattern of seeding from the pelvis and that most patients enter the disease as oligometastatic. In this study, we used whole-body magnetic resonance imaging (WB-MRI) to assess the anatomical distribution of oligo- and polymetastatic disease and the impact of the initial treatment on this distribution in patients.

Materials And Methods: WB-MRI examinations of patients with a rising prostate-specific antigen (PSA) after radical treatment by surgery or/and radiotherapy were analyzed for disease recurrence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02700-2DOI Listing
March 2019
1 Read

Artificial urinary sphincter longevity following transurethral resection of the prostate in the setting of prostate cancer.

World J Urol 2019 Mar 2. Epub 2019 Mar 2.

Division of Urology, NorthShore University HealthSystem, Evanston, USA.

Purpose: Refractory urinary incontinence after channel transurethral resection of the prostate (cTURP) (TURP in the setting of prostate cancer) is a rare occurrence treated with artificial urinary sphincter (AUS). We sought to characterize those patients receiving AUS after cTURP and understand device longevity.

Materials And Methods: We identified patients who underwent cTURP and AUS placement in SEER-Medicare from 2002 to 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02684-zDOI Listing
March 2019
1 Read

Re: Radical Prostatectomy or Watchful Waiting in Prostate Cancer-29-Year Follow-up.

Eur Urol 2019 Feb 27. Epub 2019 Feb 27.

Department of Urology, University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2019.02.021DOI Listing
February 2019

A Transcriptomic Signature of Tertiary Gleason 5 Predicts Worse Clinicopathological Outcome.

BJU Int 2019 Mar 2. Epub 2019 Mar 2.

Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY.

Objective: to investigate the genomic features of tertiary pattern 5 (TP5) on radical prostatectomy specimens in an effort to explain the poor clinical outcomes associated with this disease subtype.

Patients & Methods: Data from 159 men with Gleason Grade Group (GGG) 3 or 4 were considered. All patients had Decipher diagnostic testing with transcript profiles and SCAN-normalized expression of coding genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bju.14740DOI Listing

Differential response to neoadjuvant hormonal therapy in prostate cancer: Predictive morphological parameters and molecular markers.

Prostate 2019 Mar 2. Epub 2019 Mar 2.

The Key Laboratory of Experimental Teratology, Ministry of Education and Department of Pathology, Shandong University, School of Basic Medical Sciences, Jinan, China.

Objectives: The predictive value of the histological parameters and molecular markers for neoadjuvant hormonal therapy (NHT) in prostate cancer (PCa) has not been well established. The aim of this study is to determine pathological variables that can predict differences in response to NHT in PCa.

Methods: A total of 85 locally high risk PCa patients with matched preoperative needle biopsies and radical prostatectomy (RP) specimens were included. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pros.23777
Publisher Site
http://dx.doi.org/10.1002/pros.23777DOI Listing
March 2019
5 Reads
3.565 Impact Factor

Ga-PSMA PET/CT-based metastasis-directed radiotherapy for oligometastatic prostate cancer recurrence after radical prostatectomy.

World J Urol 2019 Mar 1. Epub 2019 Mar 1.

Radiotherapy Department, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Purpose: The aim of this communication was to assess the efficacy of directed oligometastatic radiotherapy (RT) based on Ga-PSMA PET/CT in patients with prostate cancer (PCa) biochemical relapse (BCR) after primary treatment with curative intent.

Methods: This is a retrospective analysis of a monocentric cohort of PCa patients diagnosed with oligometastatic disease on Ga-PSMA PET/CT and treated with metastasis-directed RT. Inclusion criteria were: histologically proven PCa, BCR after primary treatment with curative intent, oligometastatic disease defined as ≤ 3 metastatic lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02701-1DOI Listing
March 2019
1 Read

Comparing radiomic classifiers and classifier ensembles for detection of peripheral zone prostate tumors on T2-weighted MRI: a multi-site study.

BMC Med Imaging 2019 Feb 28;19(1):22. Epub 2019 Feb 28.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Background: For most computer-aided diagnosis (CAD) problems involving prostate cancer detection via medical imaging data, the choice of classifier has been largely ad hoc, or been motivated by classifier comparison studies that have involved large synthetic datasets. More significantly, it is currently unknown how classifier choices and trends generalize across multiple institutions, due to heterogeneous acquisition and intensity characteristics (especially when considering MR imaging data). In this work, we empirically evaluate and compare a number of different classifiers and classifier ensembles in a multi-site setting, for voxel-wise detection of prostate cancer (PCa) using radiomic texture features derived from high-resolution in vivo T2-weighted (T2w) MRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12880-019-0308-6DOI Listing
February 2019
1 Read

5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors.

Int J Mol Sci 2019 Feb 27;20(5). Epub 2019 Feb 27.

Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.

This study aimed to validate whether 5-hydroxymethylcytosine (5hmC) level in combination with ERG expression is a predictive biomarker for biochemical failure (BF) in men undergoing radical prostatectomy (RP) for prostate cancer (PCa). The study included 592 PCa patients from two consecutive Danish RP cohorts. 5hmC level and ERG expression were analyzed using immunohistochemistry in RP specimens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20051025DOI Listing
February 2019

Down-Regulation of Nfatc1 Suppresses Proliferation, Migration, Invasion, and Warburg Effect in Prostate Cancer Cells.

Med Sci Monit 2019 Feb 28;25:1572-1581. Epub 2019 Feb 28.

Department of Urology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China (mainland).

BACKGROUND Prostate cancer (PCa), accounting for 28% of all male cancer cases, is the second leading cause of cancer-related death among men. NFATc1, belonging to the NFAT family, is overexpressed in PCa and is correlated with the risk of recurrence after radical prostatectomy. MATERIAL AND METHODS In the present study, the expression of NFATc, c-myc, and PKM2 in PCa cells was regulated by lentiviruses and then detected by real-time PCR and Western blot analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.910998DOI Listing
February 2019