Search Our Scientific Publications & Authors

J Med Imaging Radiat Oncol 2022 Jun 25. Epub 2022 Jun 25.

Department of Radiation Oncology, Auckland City Hospital, Auckland, New Zealand.

Background: Radical prostatectomy and radical radiotherapy have equivalent survival outcomes in the treatment of localised prostate cancer but differing side-effect profiles. The 2018 Faculty of Radiation Oncology of the Royal Australasian College of Radiologists (RANZCR) position statement recommends that patients have the opportunity to discuss all suitable treatment options, ideally with the relevant specialist. This study aimed to determine the number and characteristics of men referred to radiation oncology before undergoing radical prostatectomy in the years immediately preceding the 2018 RANZCR position statement. Read More

Prostate Cancer Prostatic Dis 2022 Jun 24. Epub 2022 Jun 24.

Division of Urology, Department Of Oncology, School of Medicine, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy.

Background: Nowadays a tool able to predict the risk of lymph-node invasion (LNI) in patients underwent target biopsy (TB) only before radical prostatectomy (RP) is still lacking. Our aim is to develop a model based on mp-MRI and target biopsy (TB) alone able to predict the risk of LNI.

Methods: We retrospectively extracted data of patients with preoperative positive mp-MRI and TB only who underwent RARP with ePLND from April 2014 to March 2020. Read More

Eur Urol 2022 Jun 21. Epub 2022 Jun 21.

Department of Surgical Sciences, University of Turin and Città della Salute e della Scienza, Turin, Italy.

Background: Despite an expected increase in prostate cancer (PCa) incidence in the renal transplant recipient (RTR) population in the near future, robot-assisted radical prostatectomy (RARP) in these patients has been poorly detailed. It is not well understood whether results are comparable to RARP in the non-RTR setting.

Objective: To describe the surgical technique for RARP in RTR and report results from our multi-institutional experience. Read More

Curr Opin Urol 2022 Jul;32(4):358-363

Department of Pathology, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: Due to the limited number of cases, there are no guidelines for basal cell carcinoma (BCC) of the prostate. This review combines an unpublished case report of a 55-year-old patient with BCC with an assessment of the latest literature.

Recent Findings: BCC of the prostate has previously been described in only approximately 140 cases. Read More

Front Oncol 2022 7;12:906936. Epub 2022 Jun 7.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: It has been reported that perineural invasion (PNI) after radical prostatectomy (RP) is associated with unfavorable prostate cancer (PCa) prognosis. However, the clinicopathological factors especially hematological parameters that influenced PNI remain unknown. Our aim was to explore the relationship between clinicopathological parameters and PNI in patients who underwent RP. Read More

Front Surg 2022 7;9:900528. Epub 2022 Jun 7.

Department of Surgical Sciences and Urology Clinic, University of Turin and Città della Salute e della Scienza, Turin, Italy.

Introduction: Currently, the majority of prostate cancer (PCa) recurrences after non-surgical first-line treatment are managed with androgen-deprivation therapy (ADT). Salvage radical prostatectomy (sRP) is a curative alternative to ADT but yields significant morbidity. Preliminary evidence from focal salvage treatments shows similar oncological control but lower morbidity compared to sRP. Read More

J Clin Med 2022 Jun 15;11(12). Epub 2022 Jun 15.

Biotech and Healthcare Management, School of Health Care Administration, College of Management, Taipei Medical University, Taipei 110, Taiwan.

Purpose: Few studies have evaluated the prime treatment choice for men older than 80 years with acute vulnerable localized prostate cancer (AV-LPC). Clinicians have been deeply troubled by this near end-of-life medical choice for a very specific group of patients. We compared the oncological prognostication of very old patients with AV-LPC after they underwent either radical prostatectomy (RP) or massive-dose intensity-modulated radiotherapy (IMRT) coupled with long-term androgen deprivation therapy (ADT) over a long-term investigation. Read More

Diagnostics (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80130 Naples, Italy.

The management of patients with prostate cancer (PCa) and previous or synchronous colorectal cancer (CRC) represents a challenging issue. A systematic review was performed in May 2022 to summarize available evidence about the diagnosis, management, and outcomes of these patients. Twenty-seven studies involving 252 patients were identified. Read More

Diagnostics (Basel) 2022 May 24;12(6). Epub 2022 May 24.

Nuclear Medicine, Department of Medical Sciences, AOU Città Della Salute e Della Scienza di Torino, University of Turin, 10126 Turin, Italy.

Prostate-specific-membrane-antigen/positron-emission-tomography (PSMA-PET) can accurately detect disease localizations in prostate cancer (PCa) patients with early biochemical recurrence/persistence (BCR/BCP), allowing for more personalized image-guided treatments in oligometastatic patients with major impact in the case of bone metastases (BM). Therefore, this study aimed to identify predictors of BM at PSMA-PET in early-BCR/BCP hormone-sensitive PCa (HSPC) patients, previously treated with radical intent (radiotherapy or radical prostatectomy ± salvage-radiotherapy (SRT)). A retrospective analysis was performed on 443 Ga-PSMA-11-PET/CT scans. Read More

Cancers (Basel) 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Precision Medicine, University of Campania "L Vanvitelli", 80138 Naples, Italy.

Background: Stromal components surrounding epithelial cancer cells seem to play a pivotal role during epithelial-to-mesenchymal transition (EMT), tumor invasion, and metastases. To identify the molecular mechanisms underlying tumor-stroma interactions may yield novel therapeutic targets for prostate cancer.

Methods: Gene expression profile of prostate-cancer associated fibroblast (PCAF) and prostate non-cancer associated fibroblast (PNAF) cells isolated from radical prostatectomy was performed by Illumina, analyzed, and further processed by Ingenuity: IPA software. Read More

Cancers (Basel) 2022 Jun 7;14(12). Epub 2022 Jun 7.

Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

The localization of extraprostatic extension (EPE), i.e., local spread of prostate cancer beyond the prostate capsular boundary, is important for risk stratification and surgical planning. Read More

J Clin Oncol 2022 Jun 23:JCO2102741. Epub 2022 Jun 23.

Department of Radiation Oncology, University Hospitals, Cleveland, OH.

Purpose: Metastasis-free survival (MFS), but not event-free survival, is a validated surrogate end point for overall survival (OS) in men treated for localized prostate cancer. It remains unknown if this holds true in biochemically recurrent disease after radical prostatectomy. Leveraging NRG/RTOG 9601, we aimed to determine the performance of intermediate clinical end points (ICEs) as surrogate end points for OS in recurrent prostate cancer. Read More

Eur Urol Open Sci 2022 Aug 14;42. Epub 2022 Jun 14.

Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.

Prostate Cancer Prostatic Dis 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiologic Sciences, University Sapienza of Rome, Rome, Italy.

Background And Objectives: The Reporting and Data System (RADS) have been used in the attempts to standardize the results of oncological scans in different scenarios, such as lymph nodes, adding configuration criteria to size determination. We analyze the predictive value of preoperative Node-RADS determination at imaging for pelvic lymph node (PLN) involvement in cases of prostate cancer (PC) considered for radical prostatectomy (RP) with extended lymph node dissection (eLND) and we compare it with validate predictive nomograms (MSKCC, Briganti and Gandaglia).

Methods: 150 patients with a histological diagnosis of PC (high risk or intermediate with an estimated risk for pN+ higher than 5% using the Briganti or 7% using the Gandaglia nomogram) submitted for RP with an ePLND from 2018 and 2021 were retrospectively examined. Read More

Urologia 2022 Jun 22:3915603221104048. Epub 2022 Jun 22.

Urology Department, Hasheminejad Kidney Center (HKC), Iran University of Medical Sciences (IUMS), Tehran, Iran.

Background: This study aimed to investigate the association between PSA Density and Gleason score of the positive margin after radical prostatectomy with biochemical recurrence in patients with prostate cancer.

Materials And Methods: In this retrospective cohort study, patients with prostate cancer referred to Hasheminejad Hospital in Tehran during 2009-2019, who underwent radical prostatectomy were assessed to enter the study. Patients were selected by the convenience sampling method. Read More

Langenbecks Arch Surg 2022 Jun 21. Epub 2022 Jun 21.

Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

Purpose: Inguinal hernia (IH) after radical prostatectomy (RP) is a complication that impairs quality of life; however, the factors contributing to IH after RP remain unclear. Therefore, we herein attempted to identify the factors responsible for the development of IH after RP.

Methods: We reviewed 622 patients who underwent laparoscopic or robot-assisted laparoscopic RP at our hospital between December 2011 and April 2020. Read More

Prostate Cancer Prostatic Dis 2022 Jun 21. Epub 2022 Jun 21.

Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.

Purpose: To identify trends, costs, and predictors in the use of different surgical procedures for post-radical prostatectomy incontinence (PPI).

Materials And Methods: We identified 21,589 men who were diagnosed with localized prostate cancer (PCa) and treated with radical prostatectomy (RP) from 2003 to 2017. The primary outcome was the incontinence procedure performances. Read More

Prostate Cancer Prostatic Dis 2022 Jun 21. Epub 2022 Jun 21.

Department of Urology, San Carlo di Nancy Hospital, Rome, Italy.

Background: To explore the role of preoperative MRI prostate shape in urinary incontinence after robot-assisted radical prostatectomy (RARP).

Methods: Patients were stratified into four groups based on the mpMRI prostatic apex shape: Group A (prostatic apex overlapping the membranous urethra anteriorly and posteriorly), Group B and C (overlap of the prostatic apex of the anterior or posterior membranous urethra, respectively) and Group D (no overlap). Preoperative variables and intraoperative data were compared. Read More

BJU Int 2022 Jun 20. Epub 2022 Jun 20.

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.

Objective: To assess the impact of centralisation of prostate cancer surgery and radiotherapy services on the choice of prostate cancer treatment.

Patients And Methods: This national population-based study used linked cancer registry data and administrative hospital-level data for all 16,621 men who were diagnosed between 1 Jan 2017 and 31 Dec 2018 with intermediate risk prostate cancer and underwent a radical prostatectomy (RP) or radical radiation therapy (RT) in the English National Health Service. Travel times by car to treating centres were estimated using a Geographic Information System. Read More

Urol Oncol 2022 Jun 17. Epub 2022 Jun 17.

Pathology of the University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany, Luebeck, Germany; Research Center Borstel, Leibniz Lung Center, Borstel, Germany, Borstel Germany. Electronic address:

Purpose: Nucleoporins as components of the nuclear pore complex (NCP) are known for regulating nuclear-cytoplasmatic transport. Recently, the nucleoporin POM121 was found to have an important impact on intranuclear translocation of prostate cancer (PCa)-specific tumor drivers including the androgen receptor (AR). The aim of our study was to assess the potential of POM121 as a prognostic biomarker. Read More

Front Oncol 2022 2;12:907625. Epub 2022 Jun 2.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Urological Department, Peking University Cancer Hospital & Institute, Beijing, China.

Purpose: To investigate the association between preoperative systemic immune-inflammation index (SII) and neutrophil-lymphocyte ratio (NLR) and oncological outcomes in localized prostate cancer (PCa) patients after radical prostatectomy (RP).

Methods: Between January 2014 and December 2019, 291 patients with pathologically confirmed localized PCa who underwent RP were included in this study. The threshold values of SII and NLR for biochemical recurrence (BCR) were calculated according to Youden's index based on the receiver operating characteristic (ROC) curve, then the patients were divided into two groups by the threshold values of SII and NLR, and the clinicopathological outcomes were analyzed and compared between groups, respectively. Read More

World J Urol 2022 Jun 19. Epub 2022 Jun 19.

Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, Q1044195, USA.

Objective: To compare our initial perioperative and postoperative outcomes of the single-port (SP) transvesical radical prostatectomy (TVRP) approach with the single-port extraperitoneal radical prostatectomy (ERP) approach.

Materials And Methods: Initial consecutive seventy-eight patients underwent SP TVRP between December 2020 and October 2021. Patients with extensive previous abdominal surgeries, or low- to intermediate-risk prostate cancer were selected. Read More

Eur Urol 2022 Jun 16. Epub 2022 Jun 16.

Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Background: In a subset of patients with recurrent oligometastatic prostate cancer (PCa) salvage surgery with prostate-specific membrane antigen (PSMA)-targeted radioguidance (PSMA-RGS) might be of value.

Objective: To evaluate the oncological outcomes of salvage PSMA-RGS and determine the predictive preoperative factors of improved outcomes.

Design, Setting, And Participants: A cohort study of oligorecurrent PCa patients with biochemical recurrence (BCR) after radical prostatectomy and imaging with PSMA positron emission tomography (PET), treated with PSMA-RGS in two tertiary care centers (2014-2020), was conducted. Read More

J Robot Surg 2022 Jun 18. Epub 2022 Jun 18.

AdventHealth Global Robotics Institute, 380 Celebration Pl, Celebration, FL, USA.

Post radical prostatectomy (RP) erectile dysfunction and incontinence impacts quality of life for patients. In an objective to hasten the recovery of these functional outcomes, human placental derived allografts laid on neurovascular bundles (NVB) have been investigated. These grafts include amniotic membranes (AM) chorionic membranes (CM) or umbilical cord (UC) allografts. Read More

Mol Cancer 2022 Jun 18;21(1):132. Epub 2022 Jun 18.

Department of Internal Medicine V, Medical University Innsbruck, Hematology and Oncology and Comprehensive Cancer Center Innsbruck (CCCI), Anichstreet 35, 6020, Innsbruck, Austria.

Background: Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes that contribute to PCa tumor microenvironment (TME) alterations. Here we performed a detailed characterization of PCa tumor endothelial cells (TEC) to delineate intercellular crosstalk between TEC and the PCa TME. Read More

Int J Urol 2022 Jun 18. Epub 2022 Jun 18.

Department of Urology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.

Objectives: Semen comprises prostatic fluid and seminal vesicle fluid, and seminal vesicle fluid contains various factors such as prostaglandin E2 (PGE2), zinc, and testosterone, which play important roles in sperm motility. It is not known whether these factors affect erectile function. In this study, we investigated factors in seminal vesicle fluid that may affect erectile function. Read More

Int J Radiat Oncol Biol Phys 2022 Jun 15. Epub 2022 Jun 15.

Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia.; GenesisCare, Sydney, New South Wales, Australia; University of Sydney, Camperdown, New South Wales, Australia.

Purpose: To describe the distribution of local recurrences following radical prostatectomy (RP) as delineated using 68-Gallium-PSMA-PET/CT) in order to identify areas where current consensus guideline CTVs are insufficient or excessive and to identify predictors of recurrence location within the fossa.

Methods And Materials: Retrospective review of databases from two tertiary referral centres was performed to identify patients who underwent 68-Gallium-PSMA-PET/CT for biochemical recurrence following RP. Those with a component of local recurrence were included for further analysis. Read More

Hum Pathol 2022 Jun 15. Epub 2022 Jun 15.

Department of Pathology, Indiana University, Indianapolis, IN 46202, USA.

A wide range of treatment options is available to patients with prostate cancer. Some treatments are standard (currently used) while some are emerging therapies. Androgen deprivation therapy is typically reserved for localized or metastatic prostate cancer not amenable to surgery. Read More

Mol Oncol 2022 Jun 16. Epub 2022 Jun 16.

Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

Prostate cancer is a heterogenous disease with a need for new prognostic biomarkers. Human leukocyte antigen (HLA) genes are highly polymorphic genes central to antigen presentation to T-cells. Two alleles, HLA-A*02:01 and HLA-A*24:02, have been associated with prognosis in patients diagnosed with de novo metastatic prostate cancer. Read More

Minerva Urol Nephrol 2022 Jun 16. Epub 2022 Jun 16.

Unit of Urology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Background: The study aim was to report the results of Retzius-Sparing robot-assisted radical Prostatectomy (RSP) in high-risk prostate cancer (HR-PCa) patients in a multicentric setting of expert surgeons and to analyze predictors of positive surgical margins (PSMs) and urinary continence recovery.

Methods: We retrospectively evaluated all consecutive HR-PCa patients who underwent RSP by expert surgeons in 7 centers. Pre-, peri- and post-operative features were collected. Read More