2,309 results match your criteria Prostate Cancer - Nutrition


Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):250-263. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Prostate cancer is an international health problem and represents one of the most encountered malignancies among men. In this complex and heterogeneous disease, androgens and their receptors play a crucial role in both progression and development. Although the search for its effective treatment is still ongoing, among other priorities it requires developing better anticancer agents with greater efficacy and fewer side effects. Read More

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June 2020
1.234 Impact Factor

Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model.

Cancer Genomics Proteomics 2020 Jul-Aug;17(4):335-350

Institutional BioBank, Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy.

Epidemiological and clinical studies support the association between nutrition and development or progression of different malignancies such as colon, breast, and prostate cancer, defining these tumors as diet-associated cancer. The Mediterranean diet shows inverse associations with metabolic diseases, cardiovascular pathologies and various types of cancer. Many bioactive nutrients of the Mediterranean diet have been identified as factors protective against these types of pathologies. Read More

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http://dx.doi.org/10.21873/cgp.20193DOI Listing

Vegetable Consumption and Progression of Prostate Cancer.

Authors:
Conor P Kerley

JAMA 2020 06;323(24):2528-2529

Plant Based and Sustainability Group of the Irish Nutrition and Dietetics Institute, Dublin, Ireland.

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http://dx.doi.org/10.1001/jama.2020.6726DOI Listing

Plasma metabolomic profile in prostatic intraepithelial neoplasia and prostate cancer and associations with the prostate-specific antigen and the Gleason score.

Metabolomics 2020 Jun 17;16(7):74. Epub 2020 Jun 17.

Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., Moscow, Russia, 119991.

Introduction: The metabolic alterations reflecting the influence of prostate cancer cells can be captured through metabolomic profiling.

Objective: To characterize the plasma metabolomic profile in prostatic intraepithelial neoplasia (PIN) and prostate cancer (PCa).

Methods: Metabolomics analyses were performed in plasma samples from individuals classified as non-cancerous control (n = 36), with PIN (n = 16), or PCa (n = 27). Read More

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http://dx.doi.org/10.1007/s11306-020-01694-yDOI Listing
June 2020
3.855 Impact Factor

Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells.

Molecules 2020 Jun 12;25(12). Epub 2020 Jun 12.

Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.

High fat consumption can enhance metastasis and decrease survival in prostate cancer, but the picture remains incomplete on the epidemiological and cell-biological level, impeding progress toward individualized recommendations in the clinic. Recent work has highlighted the role of exosomes secreted by prostate cancer cells in the progression of the disease, particularly in metastatic invasion, and also the utility of targeting these extracellular vesicles for diagnostics, as carriers of disease progression markers. Here, we investigated the question of a potential impact of the chief nutritional saturated fatty acid on the exosome secretion. Read More

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http://dx.doi.org/10.3390/molecules25122722DOI Listing

Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression.

BMC Cancer 2020 Jun 15;20(1):555. Epub 2020 Jun 15.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN, USA.

Background: Prostate cancer (PC), a common malignant tumor, is the second-leading cause of cancer death among American men. Its successful treatment greatly relies on the early diagnose. Engrailed-2 (EN2) has been confirmed being existed with a high level in the urine of PC patients. Read More

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http://dx.doi.org/10.1186/s12885-020-07049-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296936PMC

Mediterranean-style dietary pattern improves cancer-related fatigue and quality of life in men with prostate cancer treated with androgen deprivation therapy: A pilot randomised control trial.

Clin Nutr 2020 May 25. Epub 2020 May 25.

School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.

Background & Aims: Cancer-related fatigue (CRF) is a prevalent and persistent symptom from androgen deprivation therapy (ADT) in prostate cancer. The Mediterranean-style dietary pattern (MED-diet) offers a plausible mechanism to mitigate CRF through reducing inflammation and improving body composition. This study aimed to evaluate the effects of a 12-week MED-diet, compared to usual care, on CRF and quality of life in men with prostate cancer treated with ADT. Read More

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http://dx.doi.org/10.1016/j.clnu.2020.05.016DOI Listing

Prevalence and causes of elevated bone mass.

Bone 2020 Jun 11;138:115476. Epub 2020 Jun 11.

Univ. Lille, CHU Lille, MABLab ULR 4490, Department of Rheumatology, 59000 Lille, France. Electronic address:

Introduction: Reports of elevated bone mass (EBM) on routine DXA scanning are not infrequent. However, epidemiological studies of EBM are few in number and definition thresholds variable. The purpose of this study was to assess the prevalence and causes of EBM in the general population referred to a single university hospital - catering for a population of 4 million inhabitants - for DXA scanning. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115476DOI Listing

Clinical stage provides useful prognostic information even after pathological stage is known for prostate cancer in the PSA era.

PLoS One 2020 11;15(6):e0234391. Epub 2020 Jun 11.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.

Background: Pathological and clinical stage are associated with prostate cancer-specific survival after prostatectomy. With PSA screening, the post-surgery prognostic utility of clinical stage is debatable in studies seeking to identify new biomarkers. Few studies have investigated clinical stage and lethal prostate cancer association after accounting for pathological stage. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289430PMC

Height, body mass index and prostate cancer risk and mortality by way of detection and cancer risk category.

Int J Cancer 2020 Jun 11. Epub 2020 Jun 11.

Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Obesity is a risk factor for advanced, but not localised, prostate cancer (PCa), and for poor prognosis. However, the detection of localised PCa through asymptomatic screening might influence these associations. We investigated height and body mass index (BMI) among 431 902 men in five Swedish cohorts in relation to PCa risk, according to cancer risk category and detection mode, and PCa-specific mortality using Cox regression. Read More

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http://dx.doi.org/10.1002/ijc.33150DOI Listing

Chronic hepatitis C virus infection and genitourinary cancers: A case-control study.

Semin Oncol 2020 Apr - Jun;47(2-3):165-167. Epub 2020 May 21.

Departments of Infectious Diseases, Infection Control and Employee Health; Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Background: Chronic Hepatitis C virus (HCV) infection has been associated with extrahepatic cancers. Few studies have reported associations between HCV and genitourinary cancers such as kidney and prostate cancers with inconsistent findings. We sought to study associations between HCV and the most common genitourinary cancers including kidney, prostate and urinary bladder. Read More

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http://dx.doi.org/10.1053/j.seminoncol.2020.04.005DOI Listing
May 2020
3.898 Impact Factor

Ganoderma lucidum: A rational pharmacological approach to surmount cancer.

Authors:
Md Faruque Ahmad

J Ethnopharmacol 2020 Jun 3;260:113047. Epub 2020 Jun 3.

Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia. Electronic address:

Ethnopharmacological Relevance: Ganoderma lucidum (G. lucidum) has been broadly used for health endorsement as well as longevity for over 2000 years in Asian countries. It is an example of an ancient remedy and known as immortality mushroom. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113047DOI Listing

Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.

Sci Adv 2020 May 29;6(18):eaaz8031. Epub 2020 Apr 29.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

The orphan nuclear receptor COUP-TFII is expressed at a low level in adult tissues, but its expression is increased and shown to promote progression of multiple diseases, including prostate cancer, heart failure, and muscular dystrophy. Suppression of COUP-TFII slows disease progression, making it an intriguing therapeutic target. Here, we identified a potent and specific COUP-TFII inhibitor through high-throughput screening. Read More

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http://dx.doi.org/10.1126/sciadv.aaz8031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190335PMC

Prevalence of Cancer in Rheumatoid Arthritis: Epidemiological Study Based on the National Health and Nutrition Examination Survey (NHANES).

Cureus 2020 Apr 28;12(4):e7870. Epub 2020 Apr 28.

Internal Medicine, University of Pittsburgh Medical Center (UPMC) Pinnacle, Lancaster, USA.

Rheumatoid arthritis (RA) is a multi-system autoimmune disease with significant morbidity and healthcare burden. It is an inflammatory condition and has been associated with lymphomas, with or without the presence of immunosuppressive therapy. However, the association of rheumatoid arthritis with other malignancies has been inconsistent. Read More

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http://dx.doi.org/10.7759/cureus.7870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255534PMC

Consumption of Fish and ω-3 Fatty Acids and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies.

Adv Nutr 2020 Jun 3. Epub 2020 Jun 3.

Internal Medicine V, Department of Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria.

Multiple studies have suggested that ω-3 fatty acid intake may have a protective effect on cancer risk; however, its true association with cancer risk remains controversial. We performed an umbrella review of meta-analyses to summarize and evaluate the evidence for the association between ω-3 fatty acid intake and cancer outcomes. We searched PubMed, Embase, and the Cochrane Database of Systematic Reviews from inception to December 1, 2018. Read More

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http://dx.doi.org/10.1093/advances/nmaa055DOI Listing
June 2020
4.891 Impact Factor

Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.

Pharmaceutics 2020 May 28;12(6). Epub 2020 May 28.

Department of Food and Nutrition, College of Science and Technology, Kookmin University, Seoul 02707, Korea.

Background: Phytosterols have physiological effects and are used as medicines or food supplements. Stigmasterol has shown anticancer effects against various cancers such as hepatoma, cholangiocarcinoma, gall bladder carcinoma, endometrial adenocarcinoma and skin, gastric, breast, prostate, and cervical cancer. However, there are no reports on stigmasterol's effects on ovarian cancer. Read More

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http://dx.doi.org/10.3390/pharmaceutics12060488DOI Listing

CCL2/CCR2 signaling in cancer pathogenesis.

Cell Commun Signal 2020 May 29;18(1):82. Epub 2020 May 29.

Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA, 90059, USA.

Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer. The progression and metastasis of prostate cancer involve a complex network of chemokines that regulate the recruitment and trafficking of immune cells. Read More

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http://dx.doi.org/10.1186/s12964-020-00589-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257158PMC
May 2020
3.378 Impact Factor

The association of diabetes with risk of prostate cancer defined by clinical and molecular features.

Br J Cancer 2020 May 29. Epub 2020 May 29.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Background: To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features.

Methods: A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and updated biennially. Read More

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http://dx.doi.org/10.1038/s41416-020-0910-yDOI Listing

The effects of shift work and sleep duration on cancer incidence in Alberta`s Tomorrow Project cohort.

Cancer Epidemiol 2020 May 25;67:101729. Epub 2020 May 25.

Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, Canada; Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Introduction: We investigated the main effects of shift work and sleep duration on cancer incidence, and effect modification of the shift work-cancer incidence association by sleep duration.

Methods: Shift work and sleep duration were assessed among 21,804 participants from Alberta`s Tomorrow Project. Incident cases of breast, prostate, colorectal and lung cancers were identified through registry linkage. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101729DOI Listing

Hematologic Markers and Prostate Cancer Risk: A Prospective Analysis in UK Biobank.

Cancer Epidemiol Biomarkers Prev 2020 May 26. Epub 2020 May 26.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Background: Risk factors for prostate cancer are not well understood. Red blood cell, platelet, and white blood cell indices may be markers of a range of exposures that might be related to prostate cancer risk. Therefore, we examined the associations of hematologic parameters with prostate cancer risk. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-19-1525DOI Listing

Yogurt, cultured fermented milk, and health: a systematic review.

Nutr Rev 2020 May 23. Epub 2020 May 23.

Department of Food Science and Technology, 258 Food Innovation Center, University of Nebraska, Lincoln, Nebraska, USA.

Consumption of yogurt and other fermented products is associated with improved health outcomes. Although dairy consumption is included in most dietary guidelines, there have been few specific recommendations for yogurt and cultured dairy products. A qualitative systematic review was conducted to determine the effect of consumption of fermented milk products on gastrointestinal and cardiovascular health, cancer risk, weight management, diabetes and metabolic health, and bone density using PRISMA guidelines. Read More

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http://dx.doi.org/10.1093/nutrit/nuaa013DOI Listing

Racial differences in prostate cancer: does timing of puberty play a role?

Br J Cancer 2020 May 22. Epub 2020 May 22.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

The burden of prostate cancer has a remarkably disproportionate distribution across racial groups. For example, in the USA, African Americans are twice as likely as individuals of European ancestry to develop or die from prostate cancer, and have a more aggressive disease nature at diagnosis. In contrast, Asian American men have the lowest incidence and mortality rates of prostate cancer. Read More

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http://dx.doi.org/10.1038/s41416-020-0897-4DOI Listing

Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.

Proc Natl Acad Sci U S A 2020 Jun 20;117(23):13000-13011. Epub 2020 May 20.

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712;

Extensive studies in prostate cancer and other malignancies have revealed that l-methionine (l-Met) and its metabolites play a critical role in tumorigenesis. Preclinical and clinical studies have demonstrated that systemic restriction of serum l-Met, either via partial dietary restriction or with bacterial l-Met-degrading enzymes exerts potent antitumor effects. However, administration of bacterial l-Met-degrading enzymes has not proven practical for human therapy because of problems with immunogenicity. Read More

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http://dx.doi.org/10.1073/pnas.1917362117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293657PMC
June 2020
9.809 Impact Factor

Estrogen receptor β exerts tumor suppressive effects in prostate cancer through repression of androgen receptor activity.

PLoS One 2020 15;15(5):e0226057. Epub 2020 May 15.

Department of Biology and Biochemistry, University of Houston, Center for Nuclear Receptors and Cell Signaling, Science & Engineering Research Center, Houston, Texas, United States of America.

Estrogen receptor β (ERβ) was first identified in the rodent prostate and is abundantly expressed in human and rodent prostate epithelium, stroma, immune cells and endothelium of the blood vessels. In the prostates of mice with inactivated ERβ, mutant phenotypes include epithelial hyperplasia and increased expression of androgen receptor (AR)-regulated genes, most of which are also upregulated in prostate cancer (PCa). ERβ is expressed in both basal and luminal cells in the prostate while AR is expressed in luminal but not in the basal cell layer which harbors the prostate stem cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226057PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228066PMC

Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer.

Mol Carcinog 2020 Aug 11;59(8):955-966. Epub 2020 May 11.

Department of Urology, Case Western Reserve University, Cleveland, Ohio.

Maspin repression is frequently observed in prostate cancer; however, the molecular mechanism(s) causing the loss is not completely understood. Here, we demonstrate that inhibition of class I histone deacetylases (HDACs) mediates re-expression of maspin which plays an essential role in suppressing proliferation and migration capability in prostate cancer cells. Human prostate cancer LNCaP and DU145 cells treated with HDAC inhibitors, sodium butyrate, and trichostatin A, resulted in maspin re-expression. Read More

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http://dx.doi.org/10.1002/mc.23214DOI Listing
August 2020
4.808 Impact Factor

Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.

Nat Commun 2020 May 8;11(1):2300. Epub 2020 May 8.

Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38, 63001, Clermont-Ferrand, France.

One of the most important but less understood step of epithelial tumourigenesis occurs when cells acquire the ability to leave their epithelial compartment. This phenomenon, described as basal epithelial cell extrusion (basal extrusion), represents the first step of tumour invasion. However, due to lack of adequate in vivo model, implication of emblematic signalling pathways such as Ras/Mitogen-Activated Protein Kinase (MAPK) and phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathways, is scarcely described in this phenomenon. Read More

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http://dx.doi.org/10.1038/s41467-020-16123-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210301PMC

Growth Inhibitory and Pro-Apoptotic Effects of Ornamental Pomegranate Extracts in Du145 Human Prostate Cancer Cells.

Nutr Cancer 2020 5;72(6):932-938. Epub 2019 Sep 5.

Laboratoire PEIRENE EA7500, Faculté de Pharmacie, Université de Limoges, Limoges, France.

Prostate cancer is the most common form of cancer in the male. Epidemiological studies have associated increased cancer incidence with reduced consumption of fruit and vegetables. This study was aimed to investigate the influence of dwarf pomegranate extracts (peel, juice, and seeds oil) on the proliferation and apoptosis of human prostate androgen-independent cell line DU145. Read More

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http://dx.doi.org/10.1080/01635581.2019.1660385DOI Listing
September 2019

An elevated neutrophil-to-lymphocyte ratio associates with weight loss and cachexia in cancer.

Sci Rep 2020 May 5;10(1):7535. Epub 2020 May 5.

Precision Genomics, Intermountain Healthcare, St. George, UT 84790, USA.

Systemic inflammation is present during and serves as a diagnostic tool for cancer-associated cachexia and is detrimental to serum 25-hydroxyvitamin D (25(OH)D) concentrations in non-cancer conditions. The neutrophil-to-lymphocyte ratio (NLR) is a desirable measure of systemic inflammation because it is easily calculated from a routine complete blood cell count with differentials. We sought to determine if an elevation in the NLR associates with greater weight loss, cachexia, and lower serum 25-hydroxyvitamin D (25(OH)D) concentrations in patients with advanced cancer. Read More

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http://dx.doi.org/10.1038/s41598-020-64282-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200806PMC

Dietary Tomato or Lycopene Do Not Reduce Castration-Resistant Prostate Cancer Progression in a Murine Model.

J Nutr 2020 Jul;150(7):1808-1817

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Background: Dietary tomato products or lycopene protect against prostate carcinogenesis, but their impact on the emergence of castration-resistant prostate cancer (CRPC) is unknown.

Objective: We hypothesized that tomato or lycopene products would reduce the emergence of CRPC.

Methods: Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice were castrated at 12-13 wk and the emergence of CRPC was monitored by ultrasound in each study. Read More

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http://dx.doi.org/10.1093/jn/nxaa107DOI Listing

Impact of Ga-PSMA PET/CT in the treatment of prostate cancer: Initial experience in Spain.

Rep Pract Oncol Radiother 2020 May-Jun;25(3):405-411. Epub 2020 Apr 12.

Department of Radiation Oncology, Hospital Universitario Quirónsalud Madrid, 28223 Pozuelo de Alarcón, Madrid, Spain.

Aim: To evaluate whether positron-emission tomography/computed tomography with Ga-PSMA (Ga-PSMA PET/CT) influences the therapeutic management of patients with primary or recurrent prostate cancer (PCa).

Background: Although Ga-PSMA PET/CT is one of the best options for staging or restaging patients with PCa, its availability is still very limited in Spain. The present study reports the results of the first group of patients in Spain who underwent Ga-PSMA PET/CT imaging. Read More

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http://dx.doi.org/10.1016/j.rpor.2020.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184231PMC

Systemic Immune Response and Cancer Risk: Filling the Missing Piece of Immuno-Oncology.

Cancer Res 2020 May;80(9):1801-1803

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

While immuno-oncology has made significant advances in activating local tumor immune responses, leading to improved outcomes, the role of systemic immunity in cancer incidence remains poorly understood. Le Cornet and colleagues prospectively studied circulating immune cells quantified by DNA methylation markers in relation to incidence of breast, colorectal, lung, and prostate cancer among initially healthy individuals. A positive association with cancer risk was observed for higher FOXP3 T-cell-mediated immune tolerance and lower CD8 T-cell-mediated cytotoxicity. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-20-0730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213044PMC

Is there a non-linear relationship between dietary protein intake and prostate-specific antigen: proof from the national health and nutrition examination survey (2003-2010).

Lipids Health Dis 2020 May 2;19(1):82. Epub 2020 May 2.

Department of Urology, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou, China.

Background: Growing evidence demonstrated that dietary protein intake may be a risk factor for prostate cancer and elevate the level of prostate-specific antigen (PSA). However, proof for the correlation between dietary protein intake and PSA in American adults without prostate tumor history is limited. Our goal was to investigate the association of dietary protein intake with PSA using the National Health and Nutrition Examination Survey (NHANES) (2003-2010) database. Read More

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http://dx.doi.org/10.1186/s12944-020-01234-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195731PMC

Integrin-associated CD151 is a suppressor of prostate cancer progression.

Am J Transl Res 2020 15;12(4):1428-1442. Epub 2020 Apr 15.

Department of Pharmacology and Nutritional Sciences, Department of Molecular and Cellular Biochemistry, and Markey Cancer Center, University of Kentucky Lexington 40536, KY, USA.

Owing to the complexity of interacting molecular networks on the cell surface, integrin-associated tetraspanin CD151 remains controversial regarding its clinical importance and functional impact in prostate cancer. The current study evaluated dynamics and clinical importance of CD151 expression and its function in prostate cancer by IHC analysis of two independent patient cohorts (n=80, 181), bioinformatic interrogation of the TCGA database, and evaluation of gene knockdown effect at the cellular level. Our data showed that aside from high mRNA expression, CD151 was primarily localized to intercellular junctions at the plasma membrane in normal prostate glands or benign tissues, regardless of nature of antibodies used. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191174PMC

Obesity Surgery and Cancer: What Are the Unanswered Questions?

Front Endocrinol (Lausanne) 2020 15;11:213. Epub 2020 Apr 15.

Division of Diabetes & Nutritional Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Obesity has become a global epidemic with a soaring economic encumbrance due to its related morbidity and mortality. Amongst obesity-related conditions, cancer is indeed the most redoubtable. Bariatric surgery has been proven to be the most effective treatment for obesity and its associated metabolic and cardiovascular disorders. Read More

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http://dx.doi.org/10.3389/fendo.2020.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174700PMC

Pretreatment elevated prognostic nutritional index predicts a favorable prognosis in patients with prostate cancer.

BMC Cancer 2020 Apr 29;20(1):361. Epub 2020 Apr 29.

Department of Urology, Xinyang Central Hospital, 1 Siyi Road, Shihe District, Xinyang, Henan, 464000, People's Republic of China.

Background: The prognostic nutritional index (PNI), an immunity and nutrition based prognostic score, was correlated with clinical outcomes in different tumors. However, the prognostic significance of PNI has not been investigated in hormone sensitive prostate cancer (PCa). The objective of this study was to determine the prognostic significance of PNI in hormone sensitive PCa. Read More

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http://dx.doi.org/10.1186/s12885-020-06879-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191702PMC
April 2020
3.362 Impact Factor

Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.

Food Funct 2020 May 29;11(5):4114-4122. Epub 2020 Apr 29.

Center for Human Nutrition David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

We evaluated if chronic consumption of quercetin (Q) with green tea extract (GTE) enhances the bioavailability of GT polyphenols (GTPs) and reduces methylation activity as previously observed in mouse xenograft tumors. In this prospective, randomized, parallel design, placebo controlled study, thirty-one men with prostate cancer consumed daily 1 gram of GTE (830 mg of GTP) with 800 mg of Q (GT + Q) or placebo (GT + PL) for four weeks before prostatectomy. First morning voided urine was collected at baseline, 3 weeks and the day of surgery, and prostate tissue on the day of surgery. Read More

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http://dx.doi.org/10.1039/d0fo00565gDOI Listing

PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway.

Mol Carcinog 2020 Jun 27;59(6):661-669. Epub 2020 Apr 27.

Department of Pathology, Suzhou Science and Technology Town Hospital, Huqiu District, Suzhou, Jiangsu, China.

Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor in the gastrointestinal tract. Prostate cancer associated transcript 6 (PCAT6) is a long noncoding RNA (lncRNA) and plays a pivotal role in tumor formation. Present study was designed to explore the function of PCAT6 in GIST. Read More

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http://dx.doi.org/10.1002/mc.23199DOI Listing

Experimental Biology 2020 Meeting Abstracts.

FASEB J 2020 Apr;34(S1)

Washington State Univ.

Dietary and nutritional factors are considered critical modulating factors in prostate cancer development. Epidemiological data have suggested to the idea that dietary consumption of lycopene, found in tomatoes, may prevent prostate cancer. This study examined the mechanism by which lycopene interacts with prostate cancer cells, with the goal of discovering less toxic treatment and prevention options. Read More

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http://dx.doi.org/10.1096/fasebj.2020.34.s1.00112DOI Listing

Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: and Study.

Biomed Res Int 2020 18;2020:6040727. Epub 2020 Mar 18.

Graduate School of Biotechnology, College of Life Science, Kyung Hee University, Yongin 446-701, Republic of Korea.

The isomers of citral (-citral and -citral) were isolated from the (DC.) Stapf oil demonstrates many therapeutic properties including anticancer properties. However, the effects of citral on suppressing human prostate cancer and its underlying molecular mechanism have yet to be elucidated. Read More

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http://dx.doi.org/10.1155/2020/6040727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103989PMC

The Calcium-Sensing Receptor is A Marker and Potential Driver of Neuroendocrine Differentiation in Prostate Cancer.

Cancers (Basel) 2020 Apr 2;12(4). Epub 2020 Apr 2.

Inserm N2C UMR1069 "Nutrition, Croissance et Cancer" Université de Tours, CEDEX 1, F-37032 Tours, France.

The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has been reported in neuroendocrine prostate cancer (NEPC), we explored herein the link between NE differentiation and the calcium-sensing receptor (CaSR). CaSR expression was evaluated by immunohistochemistry-together with NE markers-on tissue microarrays containing samples of normal prostate, localized PCa, metastatic castration resistant PCa (MCRPC) and NEPC. Read More

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http://dx.doi.org/10.3390/cancers12040860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226072PMC

Postdiagnosis Body Mass Index, Weight Change, and Mortality From Prostate Cancer, Cardiovascular Disease, and All Causes Among Survivors of Nonmetastatic Prostate Cancer.

J Clin Oncol 2020 Jun 6;38(18):2018-2027. Epub 2020 Apr 6.

Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA.

Purpose: To investigate the association of postdiagnosis body mass index (BMI) and weight change with prostate cancer-specific mortality (PCSM), cardiovascular disease-related mortality (CVDM), and all-cause mortality among survivors of nonmetastatic prostate cancer.

Methods: Men in the Cancer Prevention Study II Nutrition Cohort diagnosed with nonmetastatic prostate cancer between 1992 and 2013 were followed for mortality through December 2016. Current weight was self-reported on follow-up questionnaires approximately every 2 years. Read More

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http://dx.doi.org/10.1200/JCO.19.02185DOI Listing

A genomic and epigenomic atlas of prostate cancer in Asian populations.

Nature 2020 04 25;580(7801):93-99. Epub 2020 Mar 25.

Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Prostate cancer is the second most common cancer in men worldwide. Over the past decade, large-scale integrative genomics efforts have enhanced our understanding of this disease by characterizing its genetic and epigenetic landscape in thousands of patients. However, most tumours profiled in these studies were obtained from patients from Western populations. Read More

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http://dx.doi.org/10.1038/s41586-020-2135-xDOI Listing

Cross-sectional associations between angiotensin-converting enzyme inhibitor use and cancer diagnosis in US adults.

Clin Exp Med 2020 Mar 26. Epub 2020 Mar 26.

Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Holy Cross Centre, Calgary, Canada.

The objective of the present study was to investigate the association between angiotensin-converting enzyme (ACE) inhibitor use and cancer incidence (overall, and breast, prostate, and colorectal cancers specifically) in a large representative sample of US adults. Cross-sectional data on cancer diagnosis, timing of cancer diagnosis, ACE inhibitor use, and other characteristics were extracted from 49 512 adults aged ≥ 20 years participating in the National Health and Nutrition Examination Survey (1999-2016). Multivariable-logistic and propensity score matching (PSM) regressions examined the relationship between pre-diagnosis use of ACE inhibitors and diagnosis of all cancers, and breast, prostate, and colorectal cancers specifically. Read More

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http://dx.doi.org/10.1007/s10238-020-00622-7DOI Listing

Compliance with the 2018 World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations and Prostate Cancer.

Nutrients 2020 03 14;12(3). Epub 2020 Mar 14.

Department of Preventive Medicine and Public Health, University of Granada, 18016 Granada, Spain.

The etiology of prostate cancer (PCa) remains largely unknown. Compliance with the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) cancer prevention recommendations and its relationship to PCa was evaluated. A total of 398 incident PCa cases and 302 controls were included. Read More

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http://dx.doi.org/10.3390/nu12030768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146507PMC

Biosensing of prostate specific antigen (PSA) in human plasma samples using biomacromolecule encapsulation into KCC-1-npr-NH: A new platform for prostate cancer detection.

Int J Biol Macromol 2020 Jul 13;154:584-595. Epub 2020 Mar 13.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Prostate-specific antigen (PSA) is a high molecular weight glycoprotein that is used as a marker for the diagnosis of prostate cancer and is therefore important in the medical field. In this study, a novel sandwich type immunoassay was designed based on encapsulation of biotinylated antibody into KCC-1-npr-NH. KCC-1-npr-NH stabilized the stability of the primary antibody. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.03.093DOI Listing

A Metabolomics Analysis of Adiposity and Advanced Prostate Cancer Risk in the Health Professionals Follow-Up Study.

Metabolites 2020 Mar 10;10(3). Epub 2020 Mar 10.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Obesity is associated with a higher risk of advanced prostate cancer, but men with the same body mass index (BMI) may differ in their underlying metabolic health. Using metabolomics data from nested case-control studies in the Health Professionals Follow-Up Study, we calculated Pearson correlations between 165 circulating metabolites and three adiposity measures (BMI, waist circumference, and derived fat mass from a validated prediction equation) to identify adiposity-associated metabolites. We used Lasso to further select metabolites for prediction models of adiposity measures, which we used to calculate metabolic scores representing metabolic obesity. Read More

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http://dx.doi.org/10.3390/metabo10030099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142752PMC

Circulating liver enzymes and risks of chronic diseases and mortality in the prospective EPIC-Heidelberg case-cohort study.

BMJ Open 2020 Mar 8;10(3):e033532. Epub 2020 Mar 8.

Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

Objectives: Elevated liver enzyme concentrations in blood are indicative of liver diseases and may provide an early signal for being at risk for other chronic diseases. Our study aimed to assess the relationships of alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), alanine aminotransferase (ALT), aspartate transaminase (AST) and the De Ritis ratio (AST/ALT) with incidence and mortality of cardiovascular diseases (CVD) and the four most common cancers, that is, breast, prostate, colorectal and lung.

Setting, Participants And Outcome Measures: We analysed a case-cohort sample of the prospective European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort, including cancer (n=1632), cancer mortality (n=761), CVD (n=1070), CVD mortality (n=381) and a random subcohort (n=2739) with an average follow-up duration of 15. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064128PMC

Chemical composition of cold-pressed blackberry seed flour extract and its potential health-beneficial properties.

Food Sci Nutr 2020 Feb 20;8(2):1215-1225. Epub 2020 Jan 20.

Department of Nutrition and Food Science University of Maryland College Park MD USA.

The blackberry seed flour was cold-extracted using 50% acetone and examined for its phytochemical composition and health-beneficial properties including in vitro gut microbiota modulatory, free radical scavenging, anti-inflammatory, and antiproliferative capacities. Among identified thirteen components of blackberry seed flour extract through UHPLC-MS analysis, sanguiin H6 was the primary component and followed by ellagic acid and pedunculagin. For health-beneficial properties, the blackberry seed flour extract increased the total number of gut bacteria and shifted the abundance of specific bacterial phylum, family, or genus. Read More

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http://dx.doi.org/10.1002/fsn3.1410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020322PMC
February 2020

Dietary inflammatory index and incidence of and death from primary liver cancer: A prospective study of 103,902 American adults.

Int J Cancer 2020 Aug 17;147(4):1050-1058. Epub 2020 Mar 17.

Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Chronic inflammation plays an important role in primary liver cancer (PLC) etiology and can be influenced by dietary habits. No prospective study has investigated the association of dietary inflammatory index (DII) with PLC incidence and mortality. Therefore, we used prospective data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial to fill this gap. Read More

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http://dx.doi.org/10.1002/ijc.32954DOI Listing