154 results match your criteria Prostate Cancer - Brachytherapy Radioactive Seed Implantation Therapy


A mixed-integer linear programming optimization model framework for capturing expert planning style in low dose rate prostate brachytherapy.

Phys Med Biol 2019 Mar 27;64(7):075007. Epub 2019 Mar 27.

Department of Mechanical Engineering, 10-237 Donadeo Innovation Centre for Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada.

Low dose rate (LDR) brachytherapy is a minimally invasive form of radiation therapy, used to treat prostate cancer, and it involves permanent implantation of radioactive sources (seeds) inside of the prostate gland. Treatment planning in brachytherapy involves a decision making process for the placement of the sources in order to deliver an effective dose of radiation to cancerous tissue in the prostate while sparing the surrounding healthy tissue. Such a decision making process can be modeled as a mixed-integer linear programming (MILP) problem. Read More

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http://dx.doi.org/10.1088/1361-6560/ab075cDOI Listing
March 2019
6 Reads

Reduction of seed motion using a bio-absorbable polymer coating during permanent prostate brachytherapy using a mick applicator technique.

J Appl Clin Med Phys 2018 May 17;19(3):44-51. Epub 2018 Apr 17.

Department of Radiation Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Purpose: The addition of a braided bio-absorbable vicryl coating to the surface of radioactive seeds used for low dose rate (LDR) prostate brachytherapy is intended to reduce the incidence of seed movement and migration. Here, we present a single-institution study of the frequency and severity of seed slippage (initial seed movement) of coated seeds in comparison with uncoated seeds.

Methods: Forty-seven patients received permanent prostate brachytherapy, with either coated (n = 26) or uncoated (n = 21) seeds. Read More

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http://dx.doi.org/10.1002/acm2.12254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978941PMC
May 2018
2 Reads

Patient-reported health-related quality of life for men treated with low-dose-rate prostate brachytherapy as monotherapy with 125-iodine, 103-palladium, or 131-cesium: Results of a prospective phase II study.

Brachytherapy 2018 Mar - Apr;17(2):265-276. Epub 2017 Dec 18.

Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Purpose: To compare quality of life (QoL) after brachytherapy with one of the three approved radioactive isotopes.

Methods And Materials: Patients with mostly favorable intermediate-risk prostate cancer were treated on this prospective phase II trial with brachytherapy as monotherapy, without hormonal therapy. QoL was recorded at baseline and each follow-up by using the Expanded Prostate Cancer Index Composite instrument. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721173052
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http://dx.doi.org/10.1016/j.brachy.2017.11.007DOI Listing
January 2019
47 Reads

Expert consensus workshop report: Guideline for three-dimensional printing template-assisted computed tomography-guided I seeds interstitial implantation brachytherapy.

J Cancer Res Ther 2017 ;13(4):607-612

Department of Radiation Oncology, Peking University Third Hospital, Beijing; Chinese North Multi Center Cooperative Group of Particles Radiotherapy Specialized of Beijing Medical Association, Beijing, China.

Radioactive 125I seeds (RIS) interstitial implantation brachytherapy has been a first-line treatment for early-stage cancer of the prostate gland. However, its poor accuracy and homogeneity has limited its indication and hampered its popularization for a long time. Intriguingly, scholars based in China introduced computed tomography (CT)-guided technology to improve the accuracy and homogeneity of RIS implantation and broadened the indications. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_412_17DOI Listing
May 2018
22 Reads

Brachytherapy with Intratumoral Injections of Radiometal-Labeled Polymers That Thermoresponsively Self-Aggregate in Tumor Tissues.

J Nucl Med 2017 09 13;58(9):1380-1385. Epub 2017 Apr 13.

Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

Brachytherapy is a type of radiotherapy wherein titanium capsules containing therapeutic radioisotopes are implanted within tumor tissues, enabling high-dose radioirradiation to tumor tissues around the seeds. Although marked therapeutic effects have been demonstrated, brachytherapy needs a complicated implantation technique under general anesthesia and the seeds could migrate to other organs. The aim of this study was to establish a novel brachytherapy using biocompatible, injectable thermoresponsive polymers (polyoxazoline [POZ]) labeled with Y, which can self-aggregate above a specific transition temperature (Tt), resulting in long-term intratumoral retention of radioactivity and therapeutic effect. Read More

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http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.117.189
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http://dx.doi.org/10.2967/jnumed.117.189993DOI Listing
September 2017
14 Reads

Low-Dose Prostate Cancer Brachytherapy with Radioactive Palladium-Gold Nanoparticles.

Adv Healthc Mater 2017 Feb 24;6(4). Epub 2017 Jan 24.

Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval (CR CHU de Québec), axe Médecine Régénératrice, Québec, QC, G1L 3L5, Canada.

Prostate cancer (PCa) is one of the leading causes of death among men. Low-dose brachytherapy is an increasingly used treatment for PCa, which requires the implantation of tens of radioactive seeds. This treatment causes discomfort; these implants cannot be removed, and they generate image artifacts. Read More

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http://dx.doi.org/10.1002/adhm.201601120DOI Listing
February 2017
3 Reads

Lessons Learned from Autopsying an Unidentified Body with Iodine-125 Seeds Implanted for Prostate Brachytherapy.

J Forensic Sci 2017 Mar 22;62(2):536-540. Epub 2016 Nov 22.

Department of Forensic Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

We report here lessons learned from an autopsy case involving radioactive materials. We performed an autopsy of an unidentified mummified man with no available medical history whom from imaging findings we suspected had received radioactive seed implants for prostate brachytherapy. We returned the excised prostate and seeds to the body. Read More

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http://dx.doi.org/10.1111/1556-4029.13296DOI Listing
March 2017
2 Reads

Long-term outcome of magnetic resonance spectroscopic image-directed dose escalation for prostate brachytherapy.

Brachytherapy 2016 May-Jun;15(3):266-73. Epub 2016 Apr 20.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY. Electronic address:

Purpose: To report the long-term control and toxicity outcomes of patients with clinically localized prostate cancer, who underwent low-dose-rate prostate brachytherapy with magnetic resonance spectroscopic image (MRSI)-directed dose escalation to intraprostatic regions.

Methods And Materials: Forty-seven consecutive patients between May 2000 and December 2003 were analyzed retrospectively. Each patient underwent a preprocedural MRSI, and MRS-positive voxels suspicious for malignancy were identified. Read More

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http://dx.doi.org/10.1016/j.brachy.2016.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546833PMC
July 2017
30 Reads
1.987 Impact Factor

Learning-Based Multi-Label Segmentation of Transrectal Ultrasound Images for Prostate Brachytherapy.

IEEE Trans Med Imaging 2016 Mar 20;35(3):921-32. Epub 2015 Nov 20.

Low-dose-rate prostate brachytherapy treatment takes place by implantation of small radioactive seeds in and sometimes adjacent to the prostate gland. A patient specific target anatomy for seed placement is usually determined by contouring a set of collected transrectal ultrasound images prior to implantation. Standard-of-care in prostate brachytherapy is to delineate the clinical target anatomy, which closely follows the real prostate boundary. Read More

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http://dx.doi.org/10.1109/TMI.2015.2502540DOI Listing
March 2016
3 Reads

A review of rectal toxicity following permanent low dose-rate prostate brachytherapy and the potential value of biodegradable rectal spacers.

Prostate Cancer Prostatic Dis 2015 Jun 17;18(2):96-103. Epub 2015 Feb 17.

1] Department of Radiation Oncology, Virginia Commonwealth University Massey Cancer Center, Richmond, VA, USA [2] Department of Radiation Oncology Service, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, USA.

Permanent radioactive seed implantation provides highly effective treatment for prostate cancer that typically includes multidisciplinary collaboration between urologists and radiation oncologists. Low dose-rate (LDR) prostate brachytherapy offers excellent tumor control rates and has equivalent rates of rectal toxicity when compared with external beam radiotherapy. Owing to its proximity to the anterior rectal wall, a small portion of the rectum is often exposed to high doses of ionizing radiation from this procedure. Read More

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http://www.nature.com/articles/pcan20154
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http://dx.doi.org/10.1038/pcan.2015.4DOI Listing
June 2015
9 Reads

AAPM and GEC-ESTRO guidelines for image-guided robotic brachytherapy: report of Task Group 192.

Med Phys 2014 Oct;41(10):101501

Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

In the last decade, there have been significant developments into integration of robots and automation tools with brachytherapy delivery systems. These systems aim to improve the current paradigm by executing higher precision and accuracy in seed placement, improving calculation of optimal seed locations, minimizing surgical trauma, and reducing radiation exposure to medical staff. Most of the applications of this technology have been in the implantation of seeds in patients with early-stage prostate cancer. Read More

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https://www.aapm.org/pubs/reports/RPT_192.pdf
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http://scitation.aip.org/content/aapm/journal/medphys/41/10/
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http://dx.doi.org/10.1118/1.4895013DOI Listing
October 2014
56 Reads
2 Citations
2.630 Impact Factor

Postmortem radiation safety and issues pertaining to permanent prostate seed implantation in Japan.

Brachytherapy 2015 Mar-Apr;14(2):136-41. Epub 2014 Sep 6.

Working Group for Promotion of Permanent Seed Implantation Therapy of Prostate Cancer, Subcommittee of Brachytherapy, Medical Science and Pharmaceutical Committee, Japan Radioisotope Association, Tokyo, Japan; Department of Radiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

Purpose: If a prostate cancer patient treated with (125)I brachytherapy dies within 12 months after the treatment, prostate removal before cremation is recommended to avoid problems related to radioactivity in the ashes, such as inhalation of airborne particulate matter by crematorium staff or nearby residents. To provide guidance for such cases, a manual prepared under the editorial supervision of several professional associations was issued in 2008 in Japan. Herein, we investigated the incidence and causes of death, and the actions taken subsequent to death, among prostate cancer patients who died within 12 months after (125)I brachytherapy over a 10-year period in Japan; and we compared the results before and after the manual was issued. Read More

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http://dx.doi.org/10.1016/j.brachy.2014.08.043DOI Listing
September 2015
7 Reads

Bioevaluation of (125) I Ocu-Prosta seeds for application in prostate cancer brachytherapy.

Indian J Med Res 2014 Apr;139(4):555-60

Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.

Background & Objectives: In recent years, brachytherapy involving permanent radioactive seed implantation has emerged as an effective modality for the management of cancer of prostate. 125 I-Ocu-Prosta seeds were indigenously developed and studies were carried out to assess the safety of the indigenously developed 125 I-Ocu-Prosta seeds for treatment of prostate cancer.

Methods: Animal experiments were performed to assess the likelihood of in vivo release of 125 I from radioactive seeds and migration of seeds implanted in the prostate gland of the rabbit. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078493PMC
April 2014
17 Reads
1 Citation
1.661 Impact Factor

MRI characterization of cobalt dichloride-N-acetyl cysteine (C4) contrast agent marker for prostate brachytherapy.

Phys Med Biol 2014 May 28;59(10):2505-16. Epub 2014 Apr 28.

The University of Texas at Houston Graduate School of Biomedical Sciences, 6767 Bertner Avenue, Houston, TX 77030, USA. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Brachytherapy, a radiotherapy technique for treating prostate cancer, involves the implantation of numerous radioactive seeds into the prostate. While the implanted seeds can be easily identified on a computed tomography image, distinguishing the prostate and surrounding soft tissues is not as straightforward. Magnetic resonance imaging (MRI) offers superior anatomical delineation, but the seeds appear as dark voids and are difficult to identify, thus creating a conundrum. Read More

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http://stacks.iop.org/0031-9155/59/i=10/a=2505?key=crossref.
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http://dx.doi.org/10.1088/0031-9155/59/10/2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090919PMC
May 2014
18 Reads

Do theoretical potential and advanced technology justify the use of high-dose rate brachytherapy as monotherapy for prostate cancer?

Expert Rev Anticancer Ther 2014 Jan;14(1):39-50

Department of Radiation Oncology Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.

Low-dose rate brachytherapy (LDR-BT), involving implantation of radioactive seeds into the prostate, is an established monotherapy for most low-risk and select intermediate- and high-risk prostate cancer patients. High-dose rate brachytherapy (HDR-BT) is an advanced technology theorized to be more advantageous than LDR-BT from a radiobiological and radiophysics perspective, to the patient himself, and in terms of resource allocation. Studies of HDR-BT monotherapy have encouraging results in terms of biochemical control, patient survival, treatment toxicity and erectile preservation. Read More

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http://www.tandfonline.com/doi/full/10.1586/14737140.2013.83
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http://dx.doi.org/10.1586/14737140.2013.836303DOI Listing
January 2014
14 Reads

Evaluation of dosimetry and excess seeds in permanent brachytherapy using a modified hybrid method: a single-institution experience.

J Radiat Res 2013 May 4;54(3):479-84. Epub 2013 Jan 4.

Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

Permanent prostate brachytherapy is frequently performed worldwide, and many studies have demonstrated its favorable outcomes. Implant seeds used in this procedure contain a precise amount of radionuclide and are completely sealed. Because these seeds are not manufactured in Japan, they are expensive (6300 yen per seed) and therefore need careful management as a radioisotope. Read More

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https://academic.oup.com/jrr/article-lookup/doi/10.1093/jrr/
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http://dx.doi.org/10.1093/jrr/rrs126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650751PMC
May 2013
8 Reads

Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.

Cancer Res 2012 Nov;72(22):5956-65

Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.

Brachytherapy is a common clinical technique involving implantation of sealed radioactive "seeds" within a tumor to selectively irradiate the tumor mass while minimizing systemic toxicity. To mitigate the disadvantages associated with complex surgical implantation and subsequent device removal procedures, we have developed an alternative approach using a genetically encoded peptide polymer solution composed of a thermally responsive elastin-like polypeptide (ELP) radiolabeled with (131)I that self-assembles into radionuclide seeds upon intratumoral injection. The formation of these nontoxic and biodegradable polymer seeds led to prolonged intratumoral retention (~85% ID/tumor 7 days postinjection) of the radionuclide, elicited a tumor growth delay in 100% of the tumors in two human xenografts (FaDu and PC-3), and cured more than 67% of tumor-bearing animals after a single administration of labeled ELP. Read More

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-2127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502020PMC
November 2012
9 Reads

Preimplant factors affecting prostate D90 after transperineal interstitial prostate brachytherapy with loose (125)I seeds.

Keio J Med 2012 ;61(3):89-94

Department of Radiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

The dose received by 90% of the prostate volume (D90) is the key parameter of dosimetric analysis in prostate brachytherapy. The aim of this analysis was to identify preimplant factors affecting prostate D90 after transperineal interstitial prostate brachytherapy with loose (125)I seeds. We reviewed the records of 210 patients who underwent transperineal interstitial prostate brachytherapy with loose (125)I seeds for clinical T1/T2 prostate cancer at our institution. Read More

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February 2013
9 Reads

Evaluation of physician eye lens doses during permanent seed implant brachytherapy for prostate cancer.

J Radiol Prot 2012 Sep 2;32(3):339-47. Epub 2012 Aug 2.

Department of Medical Physics, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.

Treatment of low grade prostate cancer with permanent implant of radioactive seeds has become one of the most common brachytherapy procedures in use today. The implant procedure is usually performed with fluoroscopy image guidance to ensure that the seeds are deployed in the planned locations. In this situation the physician performing the transperineal implant is required to be close to the fluoroscopy unit and dose to the eye lens may be of concern. Read More

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http://dx.doi.org/10.1088/0952-4746/32/3/339DOI Listing
September 2012
9 Reads

³²P-chromic phosphate-Poly(L-Lactide) seeds of sustained release and their brachytherapy for prostate cancer with lymphatic metastasis.

Cancer Biother Radiopharm 2012 Sep 26;27(7):446-51. Epub 2012 Jul 26.

Department of Urology, Yangzhou First Hospital Affiliated to Southeast University, Yangzhou, China.

This study aims to develop a new agent, the ³²P-chromic phosphate-poly(l-lactide) (³²P-CP-PLLA) seed and to explore its anticancer effect against prostate cancer (Pca) with local lymphatic metastasis in nude mice. ³²P-CP-PLLA seeds of sustained release and nude mouse models of Pca with lymphatic metastasis were prepared. After 4 weeks, the tumor nude mouse models were randomly assigned into five groups. Read More

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http://dx.doi.org/10.1089/cbr.2011.1141DOI Listing
September 2012
8 Reads
1 Citation
1.381 Impact Factor

Ultrasound-fluoroscopy registration for prostate brachytherapy dosimetry.

Med Image Anal 2012 Oct 16;16(7):1347-58. Epub 2012 Jun 16.

Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.

Prostate brachytherapy is a treatment for prostate cancer using radioactive seeds that are permanently implanted in the prostate. The treatment success depends on adequate coverage of the target gland with a therapeutic dose, while sparing the surrounding tissue. Since seed implantation is performed under transrectal ultrasound (TRUS) imaging, intraoperative localization of the seeds in ultrasound can provide physicians with dynamic dose assessment and plan modification. Read More

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http://dx.doi.org/10.1016/j.media.2012.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448845PMC
October 2012
10 Reads

Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system.

J Biomed Opt 2012 Jun;17(6):066005

Johns Hopkins University, Department of Biomedical Engineering, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

Prostate brachytherapy is a popular prostate cancer treatment option that involves the permanent implantation of radioactive seeds into the prostate. However, contemporary brachytherapy procedure is limited by the lack of an imaging system that can provide real-time seed-position feedback. While many other imaging systems have been proposed, photoacoustic imaging has emerged as a potential ideal modality to address this need, since it could easily be incorporated into the current ultrasound system used in the operating room. Read More

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http://biomedicaloptics.spiedigitallibrary.org/article.aspx?
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http://dx.doi.org/10.1117/1.JBO.17.6.066005DOI Listing
June 2012
8 Reads

Preoperative treatment planning with intraoperative optimization can achieve consistent high-quality implants in prostate brachytherapy.

Med Dosim 2012 3;37(4):387-90. Epub 2012 May 3.

Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Advances in brachytherapy treatment planning systems have allowed the opportunity for brachytherapy to be planned intraoperatively as well as preoperatively. The relative advantages and disadvantages of each approach have been the subject of extensive debate, and some contend that the intraoperative approach is vital to the delivery of optimal therapy. The purpose of this study was to determine whether high-quality permanent prostate implants can be achieved consistently using a preoperative planning approach that allows for, but does not necessitate, intraoperative optimization. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S095839471200057
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http://dx.doi.org/10.1016/j.meddos.2012.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935513PMC
April 2013
9 Reads

Effects of insertion speed and trocar stiffness on the accuracy of needle position for brachytherapy.

Med Phys 2012 Apr;39(4):1811-7

Biomedical Engineering Department, University of Michigan, Ann Arbor, MI, USA.

Purpose: In prostate brachytherapy, accurate positioning of the needle tip to place radioactive seeds at its target site is critical for successful radiation treatment. During the procedure, needle deflection leads to seed misplacement and suboptimal radiation dose to cancerous cells. In practice, radiation oncologists commonly use high-speed hand needle insertion to minimize displacement of the prostate as well as the needle deflection. Read More

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http://dx.doi.org/10.1118/1.3689812DOI Listing
April 2012
5 Reads

Use of needle track detection to quantify the displacement of stranded seeds following prostate brachytherapy.

IEEE Trans Med Imaging 2012 Mar 6;31(3):738-48. Epub 2011 Dec 6.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada.

We aim to compute the movement of permanent stranded implant brachytherapy radioactive sources (seeds) in the prostate from the planned seed distribution to the intraoperative fluoroscopic distribution, and then to the postimplant computed tomography (CT) distribution. We present a novel approach to matching the seeds in these distributions to the plan by grouping the seeds into needle tracks. First, we identify the implantation axis using a sample consensus algorithm. Read More

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http://ieeexplore.ieee.org/document/6095633/
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http://dx.doi.org/10.1109/TMI.2011.2178254DOI Listing
March 2012
5 Reads

Comparison of template-matching and singular-spectrum-analysis methods for imaging implanted brachytherapy seeds.

IEEE Trans Ultrason Ferroelectr Freq Control 2011 Nov;58(11):2484-91

Brachytherapy using small implanted radioactive seeds is becoming an increasingly popular method for treating prostate cancer, in which a radiation oncologist implants seeds in the prostate transperineally under ultrasound guidance. Dosimetry software determines the optimal placement of seeds for achieving the prescribed dose based on ultrasonic determination of the gland boundaries. However, because of prostate movement and distortion during the implantation procedure, some seeds may not be placed in the desired locations; this causes the delivered dose to differ from the prescribed dose. Read More

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http://dx.doi.org/10.1109/TUFFC.2011.2105DOI Listing
November 2011
7 Reads

Brachytherapy for clinically localized prostate cancer: optimal patient selection.

Arch Esp Urol 2011 Oct;64(8):847-57

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

The objective of this review is to present an overview of each modality and delineate how to best select patients who are optimal candidates for these treatment approaches. Prostate brachytherapy as a curative modality for clinically localized prostate cancer has become increasingly utilized over the past decade; 25% of all early cancers are now treated this way in the United States (1). The popularity of this treatment strategy lies in the highly conformal nature of radiation dose, low morbidity, patient convenience, and high efficacy rates. Read More

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October 2011
3 Reads

Coregistered photoacoustic-ultrasound imaging applied to brachytherapy.

J Biomed Opt 2011 Aug;16(8):080502

Brachytherapy is a form of radiation therapy commonly used in the treatment of prostate cancer wherein sustained radiation doses can be precisely targeted to the tumor area by the implantation of small radioactive seeds around the treatment area. Ultrasound is a popular imaging mode for seed implantation, but the seeds are difficult to distinguish from the tissue structure. In this work, we demonstrate the feasibility of photoacoustic imaging for identifying brachytherapy seeds in a tissue phantom, comparing the received intensity to endogenous contrast. Read More

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http://dx.doi.org/10.1117/1.3606566DOI Listing
August 2011
3 Reads

Organ-confined prostate carcinoma radiation brachytherapy compared with external either photon- or hadron-beam radiation therapy. Just a short up-to-date.

Authors:
C Alberti

Eur Rev Med Pharmacol Sci 2011 Jul;15(7):769-74

L.D. of Surgical Semeiotics, University of Parma, Parma, Italy.

Both low dose rate (LDR) permanent either 1251 or 103Pd seed implant and high dose rate (HDR) 1921r temporary implant are an excellent way to release high dose of ionizing radiations to cancerous lesions while significantly sparing the surrounding healthy tissues. Therefore, the radiation brachytherapy, among the established treatment options of organ-confined prostate carcinoma--interstitial radiofrequency, high intensity focused ultrasound, cryotherapy--has gained large acceptance in the last decades. The LDR permanent interstitial radioactive seed implantation is often used as monotherapy for low risk prostate carcinoma whereas the HDR temporary implant may useful to treat intermediate-to-high risk prostate tumors as a radiation boost to combined external beam radiation therapy (EBRT). Read More

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July 2011
4 Reads

Long-term results of a phase II trial of ultrasound-guided radioactive implantation of the prostate for definitive management of localized adenocarcinoma of the prostate (RTOG 98-05).

Int J Radiat Oncol Biol Phys 2011 Sep 4;81(1):1-7. Epub 2011 Apr 4.

Radiation Oncology Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Purpose: To evaluate the long-term effectiveness of transrectal ultrasound-guided permanent radioactive I125 implantation of the prostate for organ confined adenocarcinoma of the prostate compared with historical data of prostatectomy and external beam radiotherapy within a cooperative group setting.

Methods And Materials: Patients accrued to this study had histologically confirmed, locally confined adenocarcinoma of the prostate clinical stage T1b, T1c, or T2a; no nodal or metastatic disease; prostate-specific antigen level of ≤10 ng/ml; and a Gleason score of ≤6. All patients underwent transrectal ultrasound-guided radioactive I125 seed implantation into the prostate. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2010.05.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132830PMC
September 2011
8 Reads

High-field MRI-compatible needle placement robot for prostate interventions.

Stud Health Technol Inform 2011 ;163:623-9

Worcester Polytechnic Institute, Worcester, MA 01609, USA.

This paper presents the design of a magnetic resonance imaging (MRI) compatible needle placement system actuated by piezoelectric actuators for prostate brachytherapy and biopsy. An MRI-compatible modular 3 degree-of-freedom (DOF) needle driver module coupled with a 3-DOF x-y-z stage is proposed as a slave robot to precisely deliver radioactive brachytherapy seeds under interactive MRI guidance. The needle driver module provides for needle cannula rotation, needle insertion and cannula retraction to enable the brachytherapy procedure with the preloaded needles. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077613PMC
May 2011
25 Reads
3 Citations

Combining radiation therapy with interstitial radiation-inducible TNF-α expression for locoregional cancer treatment.

Cancer Gene Ther 2011 Mar 5;18(3):189-95. Epub 2010 Nov 5.

Division of Radiation Research, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057-1482, USA.

Brachytherapy (BRT) is used in the treatment of human cancers, including the cervix, breast, prostate and head and neck cancers. The primary advantage of BRT lies in the spatial conformation of the radiation deposition. Previously, we have shown that similar techniques (using hollow metallic cylinders) may be used to deliver gene-therapy vectors capable of expressing the radiation-sensitizing cytokine, tumor necrosis factor (TNF)-α, within a restricted volume of tissue. Read More

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http://dx.doi.org/10.1038/cgt.2010.69DOI Listing
March 2011
4 Reads

Brachytherapy for prostate cancer in 2010.

Authors:
O W Hakenberg

Panminerva Med 2010 Sep;52(3):183-8

Department of Urology, Rostock University, Rostock, Germany.

Permanent prostate brachytherapy by implantation of radioactive isotope seeds has become a widely accepted treatment modality for localized prostate cancer. Clinical outcome data are mature and show excellent long-term PSA recurrence-free survival over 10 years in patients with low risk tumours. Results are dependent on patient selection and implant quality. Read More

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September 2010
4 Reads

[Which modality for prostate brachytherapy?].

Authors:
A Bossi

Cancer Radiother 2010 Oct 17;14(6-7):488-92. Epub 2010 Aug 17.

Département de radiothérapie, institut Gustave-Roussy, 39 rue Camille-Desmoulins, 94805 Villejuif, France.

Brachytherapy techniques by permanent implant of radioactive sources or by temporary high-dose-rate (HDR) fractions are nowadays extensively used for the treatment of prostatic carcinoma. Long-term results (at 20 years) concerning large amount of patients have been published by major centers confirming both in terms of efficacy and toxicities that permanent implant of radioactive iodine-125 seeds yields at least the same good results of surgery and of external beam irradiation when proposed to patients affected by low-risk disease. For intermediate to high-risk tumors, HDR temporary implants are proposed as a boost for dose escalation. Read More

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http://dx.doi.org/10.1016/j.canrad.2010.06.009DOI Listing
October 2010
1 Read

Prediction of PSA bounce after permanent prostate brachytherapy for localized prostate cancer.

Int J Clin Oncol 2009 Dec 5;14(6):502-6. Epub 2009 Dec 5.

Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Background: We aimed to calculate the frequency and features of the development of a prostate-specific antigen (PSA) bounce after prostate brachytherapy alone, to correlate the bounce with clinical and dosimetric factors and to identify factors that predict PSA bounce.

Methods: PSA bounce was evaluated in 86 patients with T1-T2 prostate cancer who underwent radioactive seed implantation using iodine-125 (I-125) without hormonal therapy or external-beam radiation therapy (EBRT) from September 2004 to December 2007. A PSA bounce was defined as a rise of at least 0. Read More

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http://dx.doi.org/10.1007/s10147-009-0909-0DOI Listing
December 2009
3 Reads

Comparison of three radiotherapy modalities on biochemical control and overall survival for the treatment of prostate cancer: a systematic review.

Radiother Oncol 2009 Nov 11;93(2):168-73. Epub 2009 Sep 11.

Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, The Netherlands.

Background And Purpose: For the radiation treatment of prostate cancer high dose should be delivered for optimal biochemical control. Treatment can be given by dose-escalated external beam radiotherapy (EBRT) or external beam radiotherapy combined with a radioactive seed implantation (EBSeeds) or high-dose rate (HDR) brachytherapy (EBTI). Differences in outcome between the modalities were assessed by a systematic review. Read More

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http://dx.doi.org/10.1016/j.radonc.2009.08.033DOI Listing
November 2009
12 Reads

A comparative study of seed localization and dose calculation on pre- and post-implantation ultrasound and CT images for low-dose-rate prostate brachytherapy.

Phys Med Biol 2009 Sep 28;54(18):5595-611. Epub 2009 Aug 28.

Department of Radiation Oncology, University of Oklahoma Health Sciences Center, 825 NE 10th Street, OUPB 1430, Oklahoma City, OK 73104, USA.

This work investigates variation in the volume of the prostate measured at different stages through the prostate brachytherapy procedure for 30 patients treated with I-125 radioactive seeds. The implanted seeds were localized on post-implantation ultrasound (US) images and the effect of prostate enlargement due to edema on dose coverage for 15 patients was studied. The volume of the prostate was measured at four stages as follows: (a) 2-3 weeks prior to implantation using US imaging, (b) then at the start of the intra-operative prostate brachytherapy procedure on the day of the implant, (c) immediately post-implantation using US imaging in the operating room and (d) finally by CT imaging at nearly 4 weeks post-implantation. Read More

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http://stacks.iop.org/0031-9155/54/i=18/a=016?key=crossref.f
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http://dx.doi.org/10.1088/0031-9155/54/18/016DOI Listing
September 2009
11 Reads

Longitudinal analysis of genitourinary and bowel symptoms in prostate cancer patients following brachytherapy.

Am J Clin Oncol 2010 Feb;33(1):1-10

Division of General Internal Medicine, Department of Medicine, and Center for Clinical Effectiveness, Cincinnati, Ohio, USA.

Objectives: Multiple options with similar cure rates exist for men with localized adenocarcinoma of the prostate. Therefore, treatment-related morbidity is a major consideration for treatment selection. We present a descriptive, longitudinal analysis of genitourinary and bowel symptoms following treatment in a brachytherapy registry at the University of Cincinnati. Read More

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http://dx.doi.org/10.1097/COC.0b013e31819cd364DOI Listing
February 2010
15 Reads
2.611 Impact Factor

Prostate brachytherapy seed reconstruction with Gaussian blurring and optimal coverage cost.

IEEE Trans Med Imaging 2009 Dec 14;28(12):1955-68. Epub 2009 Jul 14.

Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

Intraoperative dosimetry in prostate brachytherapy requires localization of the implanted radioactive seeds. A tomosynthesis-based seed reconstruction method is proposed. A three-dimensional volume is reconstructed from Gaussian-blurred projection images and candidate seed locations are computed from the reconstructed volume. Read More

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http://dx.doi.org/10.1109/TMI.2009.2026412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790003PMC
December 2009
4 Reads

Peak flow rate is the best predictor of acute urinary retention following prostate brachytherapy: our experience and literature review.

Int J Urol 2009 Jun 12;16(6):558-60. Epub 2009 May 12.

Department of Urology, University of California, San Francisco, California, USA.

Objectives: We prospectively investigated risk factors for acute urinary retention (AUR) following transperineal radioactive seed implantation for prostate cancer.

Methods: A total of 273 consecutive patients underwent transperineal ultrasound-guided prostate brachytherapy for clinical T1c-T3b prostate cancer. Preoperative factors included age; International Prostate Symptom score; planimetric prostate and transition volumes (TZV) measured by transrectal ultrasound; peak flow rate; post-void residual urine; neoadjuvant hormone therapy; use of pelvic radiation; and T stage. Read More

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http://dx.doi.org/10.1111/j.1442-2042.2009.02303.xDOI Listing
June 2009
3 Reads

Salvage permanent perineal radioactive-seed implantation for treating recurrence of localized prostate adenocarcinoma after external beam radiotherapy.

BJU Int 2009 Sep 23;104(5):600-4. Epub 2009 Feb 23.

Department of Urology, University of California, San Francisco, CA 94117, USA.

Objective: To assess our experience with salvage permanent perineal radioactive-seed implantation (SPPI) as a possible therapeutic option for recurrent prostate adenocarcinoma, as salvage therapies for recurrences after definitive external beam radiotherapy (EBRT) for localized adenocarcinoma of the prostate are associated with significant morbidity and biochemical failure.

Patients And Methods: We retrospectively analysed on patients who had SPPI for localized recurrent prostate adenocarcinoma from 1996 to 2007 after primary treatment with EBRT. Excluded were patients who had other primary treatment or had no follow-up. Read More

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http://doi.wiley.com/10.1111/j.1464-410X.2009.08445.x
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http://dx.doi.org/10.1111/j.1464-410X.2009.08445.xDOI Listing
September 2009
21 Reads

Angle-dependent ultrasonic detection and imaging of two types of brachytherapy seeds using singular spectrum analysis.

J Acoust Soc Am 2008 Dec;124(6):EL347-52

Frederic L Lizzi Center for Biomedical Engineering, Riverside Research Institute, New York, NY 10038, USA.

Brachytherapy to treat prostate cancer uses transrectal ultrasound to guide implantation of titanium-shelled radioactive seeds. Transperitoneal implantation allows errors in placement that cause suboptimal dosimetry. Conventional ultrasound cannot reliably image implanted seeds; therefore, seed misplacements cannot be corrected in the operating room. Read More

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http://dx.doi.org/10.1121/1.2993743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642619PMC
December 2008
4 Reads

An experimental palladium-103 seed (OptiSeedexp) in a biocompatible polymer without a gold marker: characterization of dosimetric parameters including the interseed effect.

Med Phys 2008 Dec;35(12):5841-50

Cliniques Universitaires Saint-Luc, Radiotherapy and Oncology Department, Catholic University of Louvain, Brussels, Belgium.

Permanent implantation of 125I (iodine) or 103Pd (palladium) sources is a popular treatment option in the management of early stage prostate cancer. New sources are being developed, some of which are being marketed for different clinical applications. A new technique of adjuvant stereotactic permanent seed breast implant, similar to that used in the treatment of prostate cancer, has been proposed by [N. Read More

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http://doi.wiley.com/10.1118/1.3006151
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http://dx.doi.org/10.1118/1.3006151DOI Listing
December 2008
6 Reads

Sensorless motion planning for medical needle insertion in deformable tissues.

IEEE Trans Inf Technol Biomed 2009 Mar 31;13(2):217-25. Epub 2008 Dec 31.

Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599-3175, USA.

Minimally invasive medical procedures such as biopsies, anesthesia drug injections, and brachytherapy cancer treatments require inserting a needle to a specific target inside soft tissues. This is difficult because needle insertion displaces and deforms the surrounding soft tissues causing the target to move during the procedure. To facilitate physician training and preoperative planning for these procedures, we develop a needle insertion motion planning system based on an interactive simulation of needle insertion in deformable tissues and numerical optimization to reduce placement error. Read More

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http://dx.doi.org/10.1109/TITB.2008.2008393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822650PMC
March 2009
2 Reads

Optimal matching for prostate brachytherapy seed localization with dimension reduction.

Med Image Comput Comput Assist Interv 2009 ;12(Pt 1):59-66

Department of Electrical and Computer Eng., Johns Hopkins University, USA

In prostate brachytherapy, x-ray fluoroscopy has been used for intra-operative dosimetry to provide qualitative assessment of implant quality. More recent developments have made possible 3D localization of the implanted radioactive seeds. This is usually modeled as an assignment problem and solved by resolving the correspondence of seeds. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242447PMC
June 2010
4 Reads

Robotic brachytherapy of the prostate.

Authors:
Kyle J Wilson

Crit Rev Biomed Eng 2009 ;37(1-2):59-106

Department of Medical Physics & Applied Radiation Sciences, McMaster University, Canada.

Recent applications of robotics in the field of prostate brachytherapy are seeding the future and could potentially lead to a fully automated prostate brachytherapy surgery. Currently, a typical prostate brachytherapy surgery involves the implantation of upwards of 100 radioactive I-125 seeds by a surgeon. This review supplies background information on prostate biology, brachytherapy of the prostate, robotic brachytherapy, and transrectal ultrasound. Read More

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May 2010
5 Reads

[CT guided radioactive seed (125)I implantation in treating multiple bone metastasis].

Zhonghua Yi Xue Za Zhi 2008 Oct;88(39):2739-42

Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Objective: To investigate the clinical value of CT guided radioactive seed (125)I implantation in treating bone metastasis.

Methods: 28 multiple bone metastatic tumor patients with 116 metastatic lesions totally, adenocarcinoma of lung in 6 cases, squamous cell carcinoma of lung, renal clear-cell carcinoma, and carcinoma of prostate in 4 cases each, hepatocellular carcinoma and colon carcinoma in 3 cases each, breast carcinoma in 2 cases, and malignant schwannoma and pancreatic cancer in 1 case each, 13 males and 15 females, aged 49.8, underwent CT guided radioactive seed (125)I implantation into bone metastatic lesions. Read More

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October 2008
4 Reads

Randomized trial to assess the efficacy of intraoperative steroid use in decreasing acute urinary retention after transperineal radioactive iodine-125 implantation for prostate cancer.

Cancer 2008 Nov;113(9):2605-9

Department of Radiation Oncology, University Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA.

Background: Acute urinary retention is a potential complication of brachytherapy, with the literature estimating that 5% to 22% of patients require catheterization within 48 hours after implantation. In theory, postimplantation edema could be reduced by using intraoperative steroids. A prospective trial was conducted randomizing patients to a single intraoperative dose of dexamethasone versus no steroid use. Read More

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http://dx.doi.org/10.1002/cncr.23905DOI Listing
November 2008
10 Reads

Angle-dependent ultrasonic detection and imaging of brachytherapy seeds using singular spectrum analysis.

J Acoust Soc Am 2008 Apr;123(4):2148-59

Frederic L. Lizzi Center for Biomedical Engineering, Riverside Research Institute, 156 William Street, 9th Floor, New York, New York 10038, USA.

Transrectal-ultrasound-guided brachytherapy uses small titanium-shelled radioactive seeds to locally treat prostate cancer. During the implantation procedure, needles inserted transperitoneally cause gland movement resulting in seed misplacement and suboptimal dosimetry. In a previous study, an algorithm based on singular spectrum analysis (SSA) applied to envelope-detected ultrasound signals was proposed to determine seed locations [J. Read More

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http://dx.doi.org/10.1121/1.2875740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677315PMC
April 2008
6 Reads