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Urol Int 2015 17;95(2):125-31. Epub 2015 Mar 17.

Department of Urology, Medical University of Graz, Graz, Austria.

Background: Active surveillance (AS) represents an expectant treatment strategy for clinically localized prostate cancer (PCa) with low-risk features.

Objective: The actual management as well as the pros and cons of AS were evaluated.

Methods: A systematic review of the recent literature was performed using the Medline databases. Read More

Urol Oncol 2014 May 12;32(4):426-32. Epub 2013 Dec 12.

Department of Pathology, CHU-Universite de Poitiers, Poitiers, France; Centre d'etude et de Recherche sur les Pathologies Prostatique (CeRePP), Hospital Tenon, Assistance Publique Hôpitaux de Paris, Paris, France. Electronic address:

Objectives: Genome-wide association studies have identified variants at multiple loci associated with prostate cancer (PCa) risk. Some of these loci include candidate susceptibility genes, such as MSMB, HNF1β, and C-terminal-binding protein (CtBP2). Except for MSMB, the clinicopathological significance of these genes has not been investigated. Read More

Cancer Biol Ther 2011 Dec 15;12(12):1078-84. Epub 2011 Dec 15.

Department of Oncology and Diagnostic Sciences, Dental School and Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA.

Prostate cancer is the second leading cause of cancer deaths among men. The availability of animal models that represent the events and factors that exist in the natural history and biology of human prostate cancer is essential in dealing with prostate cancer. In recent decades and presently, emphasis has been directed at the development and employment of prostate cancer induced in transgenic mice. Read More

Cancer 1999 Aug;86(3):463-9

Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Background: To understand better the natural history and biology of prostate carcinoma occurring in Japanese patients, the authors attempted to define changes with time in prostate specific antigen (PSA) measurements in 48 men with clinically resectable T1-T3 nonmetastatic disease.

Methods: The authors analyzed PSA changes prospectively in prostate carcinoma patients who were managed by watchful waiting. PSA doubling time was calculated by linear regression. Read More

Monogr Pathol 1992 (34):183-97

While probably not necessary in routine diagnosis, whole-mount sections of radical prostatectomy specimens can provide valuable information that is difficult to obtain by other means. Contrary to popular belief, the technique can be carried out in the routine histology laboratory with only minor modifications of existing methods. The use of this technique has provided valuable insight into the tumor biology of early stage prostatic cancer pointing to a multifocal origin for this disease. Read More

Boll Soc Ital Biol Sper 1988 Jun;64(6):555-61