207,082 results match your criteria Prostate


[Robot-assisted laparoscopic bladder diverticulum resection (RABDR)].

Aktuelle Urol 2021 May 11. Epub 2021 May 11.

Sozialstiftung Bamberg, Klinik für Urologie, Kinderurologie und roboterassistierte minimalinvasive Urologie, Bamberg.

Aims:  Since October 2018, urinary bladder diverticulum resections at our Department of Urology have been carried out with robot assistance and with minimal invasivion, Paediatrical urological and robot-assisted minimally invasive urological surgery for the Bamberg Social Foundation were performed with the DaVinci robotic system. The aim of the present study was to record the surgical results of our patients and to compare these if necessary with available data on optimal diagnostic and therapy.

Methods:  In this retrospective analysis, we included all patients who received RAHDR between October 2018 and March 2020. Read More

View Article and Full-Text PDF

Population-Level Uptake of Moderately Hypofractionated Definitive Radiotherapy in the Treatment of Prostate Cancer.

Int J Radiat Oncol Biol Phys 2021 May 8. Epub 2021 May 8.

School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia; Department of Radiation Oncology, Calvary Mater Newcastle, NSW, Australia. Electronic address:

Background And Purpose: Recent evidence shows the non-inferiority of hypofractionated radiation therapy regimens compared to conventional regimens in the treatment of prostate cancer (PCa). Hypofractionation has benefits for both the patient and healthcare system, due to the shorter treatment duration. Despite this, the uptake of hypofractionation can be slow. Read More

View Article and Full-Text PDF

Effect of Medicaid Expansion on Receipt of Definitive Treatment and Time to Treatment Initiation by Racial and Ethnic Minorities and at Minority-Serving Hospitals: A Patient-Level and Facility-Level Analysis of Breast, Colon, Lung, and Prostate Cancer.

JCO Oncol Pract 2021 May;17(5):e654-e665

Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Purpose: We sought to investigate the association between Medicaid expansion under the Affordable Care Act and access to stage-appropriate definitive treatment for breast, colon, non-small-cell lung, and prostate cancer for underserved racial and ethnic minorities and at minority-serving hospitals (MSHs).

Methods: We conducted a retrospective, difference-in-differences study including minority patients with nonmetastatic breast, colon, non-small-cell lung, and prostate cancer and patients treated at MSHs between the age of 40 and 64, with tumors at stages eligible for definitive treatment from the National Cancer Database. We not only defined non-Hispanic Black and Hispanic cancer patients as racial and ethnic minorities but also report findings for non-Hispanic Black cancer patients separately. Read More

View Article and Full-Text PDF

Cancer Disparities and Black American Representation in Clinical Trials Leading to the Approval of Oral Chemotherapy Drugs in the United States Between 2009 and 2019.

JCO Oncol Pract 2021 May;17(5):e623-e628

Department of Pharmacy Practice and Clinical Health Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX.

Purpose: Over the past 10 years, oral chemotherapy made up about half (45.6%) of all US Food and Drug Administration (FDA)-approved oncolytic and hematologic medications. Given the disparity in incidence and mortality rate because of certain cancers among Black Americans (BAs) in the United States, a review of BA's representation in the clinical trials that lead to the development and FDA approval of oral chemotherapy drugs becomes imperative. Read More

View Article and Full-Text PDF

Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial.

Cancer 2021 May 11. Epub 2021 May 11.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Background: Studying the differential impact of aspirin and other nonsteroidal anti-inflammatory drugs across the stages of colorectal neoplasia from early adenoma to cancer is critical for understanding the benefits of these widely used drugs.

Methods: With 13 years of follow-up, the authors prospectively evaluated the association between aspirin and ibuprofen use and incident distal adenoma (1221 cases), recurrent adenoma (862 cases), and incident colorectal cancer (CRC; 2826 cases) among men and women in the population-based Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. With multivariable-adjusted models, odds ratio (ORs) and 95% confidence intervals (CIs) for adenoma incidence and recurrence and hazard ratios (HRs) and 95% CIs for incident CRC were determined. Read More

View Article and Full-Text PDF

11-Ketotestosterone: the resilience of a potent androgen in prostate cancer patients after castration.

JCI Insight 2021 May 11. Epub 2021 May 11.

Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands.

Background: Continued androgen receptor (AR) signaling constitutes a key target for treatment in metastatic castration-resistant prostate cancer (CRPC). Studies have identified 11-ketotestosterone (11KT) as a potent AR agonist, but it is unknown if 11KT is present at physiologically-relevant concentrations in CRPC patients to drive AR activation. The goal of this study was to investigate the circulating steroid metabolome including all active androgens in CRPC patients. Read More

View Article and Full-Text PDF

Second-generation hormonotherapy in prostate cancer and bone microenvironment.

Endocr Relat Cancer 2021 May 1. Epub 2021 May 1.

A Guillot, Medical oncology, Institut de Cancérologie de la Loire, Saint Priest en Jarez, France.

Prostate cancer (Pca) is the most commonly diagnosed cancer affecting men in France. Before the age of 75 years old, 1 in 8 French men will have Pca. Androgen deprivation therapies (ADT) remain the standard of care. Read More

View Article and Full-Text PDF

Bayesian Framework to Augment Tumor Board Decision Making.

JCO Clin Cancer Inform 2021 May;5:508-517

Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer & Research Institute, Tampa, FL.

Purpose: Ideally, specific treatment for a cancer patient is decided by a multidisciplinary tumor board, integrating prior clinical experience, published data, and patient-specific factors to develop a consensus on an optimal therapeutic strategy. However, many oncologists lack access to a tumor board, and many patients have incomplete data descriptions so that tumor boards must act on imprecise criteria. We propose these limitations to be addressed through a flexible but rigorous mathematical tool that can define the probability of success of given therapies and be made readily available to the oncology community. Read More

View Article and Full-Text PDF

Bladder neck stenosis after transurethral prostate surgery: a systematic review and meta-analysis.

World J Urol 2021 May 11. Epub 2021 May 11.

S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.

Purpose: Bladder neck stenosis (BNS) is a long-term complication of surgical procedures for benign prostatic hyperplasia (BPH). We performed a systematic literature review and a meta-analysis of the incidence of BNS after transurethral procedures for BPH.

Methods: We performed a systemic literature review using MEDLINE, EMBASE, and Cochrane Central Controlled Register of Trials. Read More

View Article and Full-Text PDF

Effects of orlistat combined with enzalutamide and castration through inhibition of fatty acid synthase in a PC3 tumor-bearing mouse model.

Biosci Rep 2021 May 11. Epub 2021 May 11.

Chung Shan Medical University Hospital, Taichung, Taiwan.

Androgen deprivation therapy (ADT) is one of the typical treatments used for patients with prostate cancer (PCa). ADT, however, may fail when PCa develops castration-resistance. Fatty acid synthase (FASN), a critical enzyme involved in fatty acid synthesis, is found to be upregulated in PCa. Read More

View Article and Full-Text PDF

Liposome-assisted enzyme catalysis: toward signal amplification for sensitive split-type electrochemiluminescence immunoassay.

Analyst 2021 May 11. Epub 2021 May 11.

College of Chemistry and Chemical Engineering, Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang 464000, China.

Developing an efficient signal amplification strategy is very important to improve the sensitivity of bioanalysis. In this paper, a liposome-assisted enzyme catalysis signal amplification strategy was developed for electrochemiluminescence (ECL) immunoassay of prostate specific antigen (PSA) in a split-type mode. The sandwich immunoreaction occurred in a 96-well plate, and glucose oxidase (GOx) encapsulated and antibody-modified liposomes were used as labels. Read More

View Article and Full-Text PDF

Doxorubicin and PD-L1 siRNA co-delivery with stem cell membrane-coated polydopamine nanoparticles for the targeted chemoimmunotherapy of PCa bone metastases.

Nanoscale 2021 May 11. Epub 2021 May 11.

Scientific Research Center, China-Japan Union Hospital, Jilin University, Changchun, China.

Programmed cell death ligand 1 (PD-L1) blockade has achieved great success in cancer immunotherapy. PD-L1 siRNA can restore the immune anti-tumor activity of T cells by downregulating the level of PD-L1 on tumor cells, but the efficiency of PD-1/PD-L1 monotherapy is relatively low. Doxorubicin (DOX) can induce tumor cell apoptosis, and then increase the release of tumor antigen. Read More

View Article and Full-Text PDF

Vesico-urethral anastomosis sampling: a forgotten tool for guiding salvage radiation after radical prostatectomy.

BJU Int 2021 May;127 Suppl 1:23-29

Department of Urology, Austin Health, Heidelberg, Vic., Australia.

Objective: To review the utility of vesicourethral anastomosis (VUA)-directed biopsy in the setting of biochemical recurrence (BCR) after radical prostatectomy (RP) for prostate cancer (PCa) in patients who have undergone evaluation by gallium-68 prostate-specific membrane antigen positron emission tomography with computed tomography ( Ga-PSMA PET/CT).

Methods: We completed a retrospective review of a prospectively maintained dataset from January 2015 to August 2020. Patient demographics were recorded for those who experienced BCR, as defined by a rise in prostate-specific antigen (PSA) level to above 0. Read More

View Article and Full-Text PDF

Primary Gleason grade and Gleason grade group at positive surgical margins: a systematic review and meta-analysis.

BJU Int 2021 May;127 Suppl 1:13-22

Adelaide Medical School, University of Adelaide Faculty of Health and Medical Sciences, Adelaide, South Australia, Australia.

Objectives: To systematically review and perform a meta-analysis of studies investigating the role of primary Gleason grade (PGG), Gleason score (GS) or Gleason grade group (GGG) at positive surgical margins (PSMs) after radical prostatectomy (RP) in predicting biochemical recurrence (BCR) and oncological outcomes.

Methods: A systematic search was conducted using the MEDLINE, Scopus, Embase and Cochrane databases according to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Studies published between 2005 and 2019 were included. Read More

View Article and Full-Text PDF

Telehealth, virtual meetings and conferences in urology: 'good' COVID side effects.

BJU Int 2021 May;127 Suppl 1:4-5

Department of Urology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Vic., Australia.

View Article and Full-Text PDF

The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers.

Cancer Metastasis Rev 2021 May 11. Epub 2021 May 11.

Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, Institut de pharmacologie de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada.

Breast and prostate cancers have a great propensity to metastasize to long bones. The development of bone metastases is life-threatening, incurable, and drastically reduces patients' quality of life. The chemokines CCL2 and CXCL12 and their respective receptors, CCR2 and CXCR4, are central instigators involved in all stages leading to cancer cell dissemination and secondary tumor formation in distant target organs. Read More

View Article and Full-Text PDF

Long-term and pathological outcomes of low- and intermediate-risk prostate cancer after radical prostatectomy: implications for active surveillance.

World J Urol 2021 May 10. Epub 2021 May 10.

Department of Urology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany.

Purpose: The safety of active surveillance (AS) in favorable intermediate-risk (FIR) prostate cancer (PCa) remains uncertain. To provide guidance on clinical decision-making, we examined long-term and pathological outcomes of low-risk and intermediate-risk PCa patients after radical prostatectomy (RP).

Methods: The study involved 5693 patients diagnosed between 1994 and 2019 with low-risk, FIR, and unfavorable intermediate-risk (UIR) PCa (stratification according to the AUA guidelines) who underwent RP. Read More

View Article and Full-Text PDF

A population-based analysis of risk factors and outcomes of prostatic abscess.

Prostate Cancer Prostatic Dis 2021 May 10. Epub 2021 May 10.

Columbia University Irving Medical Center, Department of Urology, New York, NY, USA.

Background: Prostate abscess is a severe complication of acute bacterial prostatitis. To date, a population-based analysis of risk factors and outcomes of prostatic abscess has not been performed.

Methods: Using the National Inpatient Sample from 2010 to 2015, we identified rates of prostatic abscess among non-elective hospitalizations for acute prostatitis. Read More

View Article and Full-Text PDF

What level of evidence will it take to move towards widespread adoption of transperineal prostate biopsy in the USA?

Prostate Cancer Prostatic Dis 2021 May 10. Epub 2021 May 10.

The Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.

View Article and Full-Text PDF

The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance.

Oncogene 2021 May 10. Epub 2021 May 10.

School of Life Sciences, University of Essex, Colchester, UK.

Prostate cancer (PCa) is the second most commonly occurring cancer in men, with over a million new cases every year worldwide. Tumor growth and disease progression is mainly dependent on the Androgen Receptor (AR), a ligand dependent transcription factor. Standard PCa therapeutic treatments include androgen-deprivation therapy and AR signaling inhibitors. Read More

View Article and Full-Text PDF

Metachronous prostate and colon adenocarcinomas.

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Surgery, Salmaniya Medical Complex, Manama, Bahrain.

Multiple primaries in patients with prostate cancer are uncommon. We report a case of prostate adenocarcinoma who did not receive any form of treatment, diagnosed 7 months later with colon adenocarcinoma. The patient underwent right extended hemicolectomy and recovered well. Read More

View Article and Full-Text PDF

Radical Cystectomy vs. Multimodality Treatment in T2N0M0 Bladder Cancer: A Population-based, Age-matched Analysis.

Clin Genitourin Cancer 2021 Apr 8. Epub 2021 Apr 8.

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.

Background: Controversy still exists regarding efficacy of multimodality treatment (MMT) vs. radical cystectomy (RC) for urothelial carcinoma of the urinary bladder (UCUB).

Methods: Within the SEER database (2004-2016), we retrospectively identified patients with stage T2N0M0 UCUB. Read More

View Article and Full-Text PDF

Acute and late side-effects after low dose-rate brachytherapy for prostate cancer; incidence, management and technical considerations.

Brachytherapy 2021 May 7. Epub 2021 May 7.

Radiotherapy Unit, Oncology Division, Rambam Health Care Campus, Haifa, Israel.

Purpose: To review common reported side effects and complications after primary LDR-BT (monotherapy) and discuss some of the technical aspects that could impact the treatment outcomes.

Methods And Materials: A literature search was undertaken using medical subject headings (MeSH) complemented by the authors' personal and institutional expertise.

Results: The reported incidence of acute and late grade 2 or above urinary, bowel and sexual side effects is very variable across the literature. Read More

View Article and Full-Text PDF

Predictive Value of Combining Biomarkers for Clinical Outcomes in Advanced Non-Small Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors.

Clin Lung Cancer 2021 Mar 27. Epub 2021 Mar 27.

Department of Medicine, Duke University School of Medicine, Durham, NC; Duke Cancer Institute, Duke University, Durham, NC. Electronic address:

Introduction: A high tumor mutational burden (TMB) (≥10 mut/Mb) has been associated with improved clinical benefit in non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICI) and is a tumor agnostic indication for pembrolizumab across tumor types. We explored whether combining TMB with programmed cell death ligand 1 (PD-L1) and pretreatment neutrophil-lymphocyte ratio (NLR) was associated with improved outcomes in ICI-treated NSCLC.

Methods: We retrospectively analyzed patients treated with ICI with Foundation One genomic testing, including TMB. Read More

View Article and Full-Text PDF

Impact of treatment planning quality assurance software on volumetric-modulated arc therapy plans for prostate cancer patients.

Med Dosim 2021 May 7. Epub 2021 May 7.

Department of Therapeutic Radiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Tokushima 770-8503, Japan.

Introduction: Software that evaluates the quality of treatment plans (PlanIQ) has become commercially available in recent years. It includes a feasibility assessment tool that provides the ideal dose volume histogram (DVH) for each organ at risk, based on the ideal dose falloff from the prescribed dose at the target boundary. It is important to investigate whether the PlanIQ assessment tool (Feasibility DVH) can assist treatment planners who have limited to no experience in treatment planning. Read More

View Article and Full-Text PDF

Physical activity counseling to cancer patients: How are patients addressed and who benefits most?

Patient Educ Couns 2021 Apr 27. Epub 2021 Apr 27.

Division of Physical Activity, Prevention and Cancer, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Electronic address:

Objective: This study examined cancer patients' reporting on physicians' physical activity (PA) counseling, its associations with patients' PA, and comparisons of patients' and physicians' reports of the type(s) of PA counseling provided.

Methods: Patients with breast, colorectal, or prostate cancer (n = 1206) participated in a nationwide cross-sectional study. Cancer patients' sociodemographic and treatment-related characteristics as well as self-reported PA levels (pre- and post-diagnosis) were assessed. Read More

View Article and Full-Text PDF

Molecular Subtyping in the Neoadjuvant Setting in Prostate Cancer: Envisioning the Possibilities.

Authors:
Heather H Cheng

Eur Urol 2021 May 7. Epub 2021 May 7.

Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address:

View Article and Full-Text PDF

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis.

Genome Med 2021 May 10;13(1):81. Epub 2021 May 10.

The Kinghorn Cancer Centre and Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

Background: High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclude histopathological triage of samples, and limit the ability to perform batch processing. This hindrance can often introduce technical biases when integrating patient datasets and increase experimental costs. Read More

View Article and Full-Text PDF

High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.

Hematology 2021 Dec;26(1):380-387

Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, People's Republic of China.

Objectives: Acute myeloid leukaemia (AML) is a haematopoietic malignancy with a dismal outcome. Consequently, risk stratification based on more effective prognostic biomarkers is crucial to make accurate therapy decisions. T cell receptor gamma alternative reading frame protein (TARP) has been reported in prostate and breast cancers, but its correlation with AML remains unclear. Read More

View Article and Full-Text PDF
December 2021

Identification of potential autophagy-associated lncRNA in prostate cancer.

Aging (Albany NY) 2021 May 10;13. Epub 2021 May 10.

Department of Urology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Background: Long non-coding RNAs (lncRNAs) have been linked to autophagy. It is urgent to identify and assess the hub autophagy-associated lncRNA in prostate cancer.

Methods: Differentially expressed lncRNAs associated with autophagy were identified in prostate cancer based on The Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) data. Read More

View Article and Full-Text PDF