220,689 results match your criteria Prostate

An overview of chemotoxicity and radiation toxicity in cancer therapy.

Adv Cancer Res 2022 30;155:1-27. Epub 2022 Apr 30.

Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States. Electronic address:

While immunotherapy and targeted therapies represent major advances against different types of malignancies, the mainstay of cancer therapy continues to be radiation and surgery for localized disease, and chemotherapy for systemic disease, with the preponderance of chemotherapeutic agents (such as anthracyclines, alkylating agents, and antimetabolites) having been developed decades ago. Combination chemotherapy regimens have changed the natural history of once deadly diseases such as breast and prostate cancer and led to curative regimens in advanced hematological malignancies and testicular cancer. However, while oncologists maintain their focus on disease suppression, and where feasible, disease eradication, obstacles to achieving cure remain, such as tumor dormancy and ultimately disease recurrence, as well as both intrinsic and acquired resistance. Read More

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Featuring the guest editors for the Special Issue on Prostate Cancer, Cancer Letters.

Cancer Lett 2022 Jun 29:215807. Epub 2022 Jun 29.

Department for Biomedical Research, University of Bern, 3008, Bern, Switzerland; Department of Urology, Inselspital, Bern University Hospital, 3010, Bern, Switzerland; Translational Organoid Resource Core, Department for BioMedical Research, University of Bern, 3008, Bern, Switzerland; Bern Center for Precision Medicine, University of Bern, 3010, Bern, Switzerland. Electronic address:

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The crossroads of adenosinergic pathway and epithelial-mesenchymal plasticity in cancer.

Semin Cancer Biol 2022 Jun 29. Epub 2022 Jun 29.

Department of Basics Health Sciences and Laboratory of Cell Biology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil. Electronic address:

Epithelial-mesenchymal transition (EMT) is a key mechanism related to tumor progression, invasion, metastasis, resistance to therapy and poor prognosis in several types of cancer. However, targeting EMT or partial-EMT, as well as the molecules involved in this process, has remained a challenge. Recently, the CD73 enzyme, which hydrolyzes AMP to produce adenosine (ADO), has been linked to the EMT process. Read More

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Naringenin: A potential flavonoid phytochemical for cancer therapy.

Life Sci 2022 Jun 29:120752. Epub 2022 Jun 29.

Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Institute of Anatomy, Ludwig-Maximilian-University Munich, 80336 Munich, Germany. Electronic address:

Naringenin is an important phytochemical which belongs to the flavanone group of polyphenols, and is found mainly in citrus fruits like grapefruits and others such as tomatoes and cherries plus medicinal plants derived food. Available evidence demonstrates that naringenin, as herbal medicine, has important pharmacological properties, including anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and anti-cancer activities. Collected data from in vitro and in vivo studies show the inactivation of carcinogens after treatment with pure naringenin, naringenin-loaded nanoparticles, and also naringenin in combination with anticancer agents in various malignancies, such as colon cancer, lung neoplasms, breast cancer, leukemia and lymphoma, pancreatic cancer, prostate tumors, oral squamous cell carcinoma, liver cancer, brain tumors, skin cancer, cervical and ovarian cancer, bladder neoplasms, gastric cancer, and osteosarcoma. Read More

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Graph-based relevancy-redundancy gene selection method for cancer diagnosis.

Comput Biol Med 2022 Jun 27;147:105766. Epub 2022 Jun 27.

Centre for Machine Vision and Signal Processing, University of Oulu, Oulu, Finland; Research Unit of Medical Imaging, Physics, and Technology, Faculty of Medicine, University of Oulu, Finland.

Nowadays, microarray data processing is one of the most important applications in molecular biology for cancer diagnosis. A major task in microarray data processing is gene selection, which aims to find a subset of genes with the least inner similarity and most relevant to the target class. Removing unnecessary, redundant, or noisy data reduces the data dimensionality. Read More

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Automatic prostate and peri-prostatic fat segmentation based on pyramid mechanism fusion network for T2-weighted MRI.

Comput Methods Programs Biomed 2022 Jun 20;223:106918. Epub 2022 Jun 20.

Haikou Municipal People's Hospital and Central South University Xiangya Medical College Affiliated Hospital, Haikou 570288, China.

Background And Objective: Automatic and accurate segmentation of prostate and peri-prostatic fat in male pelvic MRI images is a critical step in the diagnosis and prognosis of prostate cancer. The boundary of prostate tissue is not clear, which makes the task of automatic segmentation very challenging. The main issues, especially for the peri-prostatic fat, which is being offered for the first time, are hazy boundaries and a large form variation. Read More

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Aptamer-based chemiluminescent optical fiber immunosensor with enhanced signal amplification for ultrasensitive detection of tumor biomarkers.

Biosens Bioelectron 2022 Jun 25;214:114505. Epub 2022 Jun 25.

Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, 130024, China. Electronic address:

With the growing demand for early diagnosis of malignant tumor, ultrasensitive detection of cancer-related biomolecules with convenient operation is of great significance for timely treatment. In this study, we develop a robust and efficient analytical system, the aptamer-based chemiluminescent optical fiber immunosensor (aptamer-COFIS), for ultrasensitive detection of biomarkers. In the aptamer-COFIS system, target aptamer-primer probe is used as the bridge to combine antibody-antigen immunoreaction on the fiber surface with chemiluminescent signal amplification. Read More

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Practice changing data and emerging concepts from recent radiation therapy randomised clinical trials.

Eur J Cancer 2022 Jun 29;171:242-258. Epub 2022 Jun 29.

Gustave Roussy, Département de Radiothérapie, F-94805, Villejuif, France; Université Paris-Saclay, Faculté de Médecine, F-94270, Le Kremlin Bicêtre, France; Université Paris-Saclay, Inserm U-1030, Laboratoire de Radiothérapie Moléculaire et d'Innovation Thérapeutique, F-94805, Villejuif, France. Electronic address:

Introduction: Oncology treatments are constantly and rapidly evolving. We aimed at highlighting the latest radiation therapy practice changing trials and emerging concepts, through an overview of recent randomised clinical trials (RCTs).

Materials And Methods: Requests were performed in the Medline database to identify all publications reporting radiation therapy RCTs from 2018 to 2021. Read More

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Bone loss induced by cancer treatments in breast and prostate cancer patients.

Clin Transl Oncol 2022 Jul 2. Epub 2022 Jul 2.

Department of Medical Oncology, Hospital General Universitario de Elche, Camino de la Almazara, 11, 03202, Alicante, Spain.

Cancer and cancer therapies are a major factor risk for osteoporosis due to bone loss and deterioration of bone microarchitecture. Both factors contribute to a decrease in bone strength and, consequently, increased bone fragility and risk of fracture. Cancer-associated bone loss is a multifactorial process, and optimal interdisciplinary management of skeletal health, accurate assessment of bone density, and early diagnosis are essential when making decisions aimed at reducing bone loss and fracture risk in patients who have received or are receiving treatment for cancer. Read More

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Exercise in men with prostate cancer: how to move on?

Support Care Cancer 2022 Jul 2. Epub 2022 Jul 2.

Department of Oncology, University of Verona Hospital Trust, Verona, Italy.

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A Case of Methicillin-Sensitive Staphylococcus aureus (MSSA) Prostate Abscess, Osteomyelitis, and Myositis Associated with MSSA Bacteremia in a 60-Year-Old Patient Presenting with Back Pain.

Am J Case Rep 2022 Jul 2;23:e936704. Epub 2022 Jul 2.

Department of Internal Medicine, Lincoln Medical Center, New York City, NY, USA.

BACKGROUND Staphylococcus aureus (SA) is a rare cause of prostatic abscess. Risk factors include genito-urinary instrumentalization and immunocompromised states. Because of the lack of guidelines on the diagnosis, management, and follow-up of SA prostate abscess, the diagnosis can sometimes be challenging. Read More

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Intraductal Carcinoma of the Prostate and Nuclear Size.

Am J Surg Pathol 2022 Jul 1. Epub 2022 Jul 1.

Department of Oncology-Pathology Karolinska Institute, Stockholm, Sweden.

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Long-Term Outcome of Prostatic Artery Embolization for Patients with Benign Prostatic Hyperplasia: Single-Centre Retrospective Study in 1072 Patients Over a 10-Year Period.

Cardiovasc Intervent Radiol 2022 Jul 1. Epub 2022 Jul 1.

SBD Analytics, Bekkevoort, Belgium.

Purpose: Assess long-term outcomes of prostatic artery embolization (PAE) for patients with benign prostatic hyperplasia (BPH).

Materials And Methods: Single centre retrospective study from 2009-2019 including 1072 patients who received PAE and had available follow-up. Patients were evaluated yearly at 1-10 years post PAE using the International Prostate Symptom Score (IPSS) and quality of life (QoL), prostate volume (PV), prostate-specific antigen (PSA), peak urinary flow rate (Qmax) and postvoid residual (PVR) volume. Read More

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The relationship between bladder storage function and frequent micturition after TURP.

World J Urol 2022 Jul 1. Epub 2022 Jul 1.

Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.

Purpose: To investigate the relationship between preoperative bladder function and frequent micturition after transurethral resection of prostate in patients with benign prostatic hyperplasia.

Methods: We retrospectively included 80 eligible patients aged 54-87 years (mean age 69.8 years) who underwent transurethral resection of the prostate at our hospital from January 2019 to October 2021. Read More

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Variation and Disparity in the Use of Prostate Cancer Risk Stratification Tools in the United States.

Eur Urol Focus 2022 Jun 28. Epub 2022 Jun 28.

Yale University School of Medicine, New Haven, CT, USA; Department of Urology, Yale School of Medicine, New Haven, CT, USA. Electronic address:

In this review we summarize evidence from US studies examining variation in the use of prostate magnetic resonance imaging (MRI) and tissue-based gene expression tests (genomic tests), focusing on sources of regional and racial variation. Large observational studies indicate that prostate MRI and genomic testing vary significantly at the regional level as measured across multiple geographic boundaries. Similarly, there is lower use of prostate MRI among Black versus White-identified patients Black in comparison to those who are White, as well as evidence of less use among Hispanic and Asian versus White patients. Read More

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Radical prostatectomy for patients with high-risk, very-high risk, or radiographic suspicion for metastatic prostate cancer: Perioperative and early oncologic results from the MUSIC statewide collaborative.

Urol Oncol 2022 Jun 28. Epub 2022 Jun 28.

Michigan State University College of Human Medicine, Grand Rapids, MI; Division of Urology, Spectrum Health Hospital System, Grand Rapids, MI; Department of Urology, Michigan Medicine, Ann Arbor, MI. Electronic address:

Objective: High-risk (HR) prostate cancer (CaP) patients are at greatest risk for occult metastases and disease progression. Radical prostatectomy (RP) provides benefit, but remains of unknown oncologic value compared with other options. We investigated outcomes of RP for HR, very-high-risk (VHR), or metastatic CaP. Read More

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Hounsfield units: A promising non-invasive tool for diagnosing benign prostatic hyperplasia.

Actas Urol Esp (Engl Ed) 2022 Jun 28. Epub 2022 Jun 28.

Universty of Health and Science Sultan Abdulhamid Han Training and Research Hospital Istanbul, Estambul, Turkey.

Objective: The clinical symptoms in benign prostatic hyperplasia (BPH) are directly proportional to prostate volume. We aimed to show whom and when to intervene in a noninvasive way, correlating the patient's subjective symptoms with objective diagnostic tools.

Material And Method: International Prostate Symptom Score (IPSS) was evaluated in patients who consulted the urology outpatient clinic for the first time with lower urinary tract symptoms (LUTS). Read More

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The role of multiparametric mri in the diagnosis of local recurrence after radical prostatectomy and before salvage radiotherapy.

Actas Urol Esp (Engl Ed) 2022 Jun 28. Epub 2022 Jun 28.

Department of Radiology, University of Rome Campus Bio-medico, Rome, Italy.

Purpose: Assess multiparametric-MRI (mp-MRI) diagnostic accuracy in the detection of local recurrence of Prostate Cancer (PCa) after Radical Prostatectomy (PR) and before Radiation Therapy (RT).

Materials And Methods: A total of 188 patients underwent 1.5-T mp-MRI after RP before RT. Read More

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Low-Dose Enzalutamide in Metastatic Prostate Cancer-Longevity Over Conventional Survival Analysis.

Clin Genitourin Cancer 2022 Jun 6. Epub 2022 Jun 6.

Ohio State University Comprehensive Cancer Center, Columbus, OH.

Background: Enzalutamide is an important drug in the treatment of prostate cancer. Standard dosing often requires dose reduction because of side effects. There is no information on survival outcomes with lower doses. Read More

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Newly Reformulated Total and Free PSA Immunoassay on Cobas e411 Analyzer Is Virtually Free from Biotin Interference.

Ann Clin Lab Sci 2022 May;52(3):504-506

Department of Pathology and Laboratory Medicine, University of Texas McGovern Medical School at Houston, Houston, TX, USA

Objective: Total and free prostate specific antigens (PSA) have been used as diagnostic markers for monitoring progress of therapy in patients with prostate cancer as well as for screening purpose. Roche total and free PSA immunoassay utilizes biotinylated antibody in assay design. As a result, both assays are affected by elevated serum biotin levels. Read More

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68Ga-FAPI-46 PET/CT in a Metastatic Castration-Resistant Prostate Cancer Patient With Low PSMA Expression.

Clin Nucl Med 2022 Jul 1. Epub 2022 Jul 1.

Nuclear Medicine Center, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

Abstract: A 70-year-old man with mCRPC (metastatic castration-resistant prostate cancer) was referred for 68Ga-PSMA PET/CT for restaging and the possibility of targeted molecular radioligand therapy with 177Lu-PSMA. Numerous 68Ga-PSMA-avid skeletal metastases with low SUVs were noted. Because of low PSMA expression, a 68Ga-FAPI-46 PET/CT was performed to evaluate the eligibility for FAPI-based radioligand therapy. Read More

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Painless rectal bleeding in patient with prostate cancer.

Gastroenterology 2022 Jun 28. Epub 2022 Jun 28.

Department of Medicine, Division of Gastroenterology, University of California San Francisco.

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Lack of Price Transparency for Prostate-Directed Radiation Therapy Relative to Radical Prostatectomy.

Int J Radiat Oncol Biol Phys 2022 Jul;113(3):518-520

Department of Radiation Oncology, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio. Electronic address:

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The emerging role of miR-653 in human cancer.

Cancer Epidemiol 2022 Jun 28;79:102208. Epub 2022 Jun 28.

Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, Heilongjiang 154000, PR China; Key Laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang 154000, PR China. Electronic address:

MicroRNAs (miRNAs) refer to a family of non-coding RNA with ~22 nucleotides in length. A high number of studies show evidence that deregulation in miRNAs expression could be implicated in the processes of many pathologies such as cancer, hypoxia, and stroke. Herein, we aimed to summarize the miR-653 expression level and molecular mechanisms through which it functions in human cancer. Read More

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CircPDHX promotes prostate cancer cell progression in vitro and tumor growth in vivo via miR-497-5p/ACSL1 axis.

Biochem Biophys Res Commun 2022 Jun 6;620:35-41. Epub 2022 Jun 6.

Department Of Urology, Huizhou Municipal Central Hospital, No.41 Erling North Road, Huicheng District, Huizhou, 516001, Guangdong, China. Electronic address:

Background: Circular RNAs (circRNAs) have been proved could regulate many cancers, including prostate cancer (PCa). In this paper, we reconnoitered the roles of circRNA pyruvate dehydrogenase complex component X (circPDHX) in PCa.

Methods: The circPDHX, microRNA (miR)-497-5p and acyl-CoA synthetase long chain family member 1 (ACSL1) contents were detected by quantitative real-time PCR and Western blot analysis. Read More

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Aspalathus linearis suppresses cell survival and proliferation of enzalutamide-resistant prostate cancer cells via inhibition of c-Myc and stability of androgen receptor.

PLoS One 2022 1;17(7):e0270803. Epub 2022 Jul 1.

Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County, Taiwan.

Enzalutamide, a nonsteroidal antiandrogen, significantly prolonged the survival of patients with metastatic castration-resistant prostate cancer (CRPC). However, patients receiving enzalutamide frequently develop drug resistance. Rooibos (Aspalathus linearis) is a shrub-like leguminous fynbos plant endemic to the Cedarberg Mountains area in South Africa. Read More

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Methodological Comparison of Mapping the Expanded Prostate Cancer Index Composite to EuroQoL-5D-3L Using Cross-Sectional and Longitudinal Data: Secondary Analysis of NRG/RTOG 0415.

JCO Clin Cancer Inform 2022 Jun;6:e2100188

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD.

Purpose: To compare the predictive ability of mapping algorithms derived using cross-sectional and longitudinal data.

Methods: This methodological assessment used data from a randomized controlled noninferiority trial of patients with low-risk prostate cancer, conducted by NRG Oncology (ClinicalTrials.gov identifier: NCT00331773), which examined the efficacy of conventional schedule versus hypofractionated radiation therapy (three-dimensional conformal external beam radiation therapy/IMRT). Read More

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Association of HSD3B1 Genotype and Clinical Outcomes in Postmenopausal Estrogen-Receptor-Positive Breast Cancer.

Ann Surg Oncol 2022 Jul 1. Epub 2022 Jul 1.

Department of Hematology and Oncology, University of Illinois Chicago, Chicago, IL, USA.

Background: Homozygous inheritance of a single-nucleotide polymorphism (1245A > C) in HSD3B1 results in an adrenal permissive phenotype of increased adrenal steroid precursor conversion to potent androgens. This is associated with poor outcomes in prostate cancer. We hypothesized that inheritance of the HSD3B1 adrenal permissive genotype would similarly negatively impact breast cancer outcomes. Read More

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Anticancer activities of Brachydin C in human prostate tumor cells (DU145) grown in 2D and 3D models: stimulation of cell death and downregulation of metalloproteinases in spheroids.

Chem Biol Drug Des 2022 Jul 1. Epub 2022 Jul 1.

Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina, Brazil.

Brachydin C (BrC) has demonstrated in vitro cytotoxic and antiproliferative effects in prostate cancer cells. In the present study, we compare the anticancer effects of BrC in DU145 cells grown in common bidimensional cultures (2D) and multicellular tumor spheroids (MCTS), often denominated 3D in vitro models, that can better mimic the microenvironment of tissues. BrC IC values obtained in the resazurin assay after 24 h of treatment were 47. Read More

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