182,722 results match your criteria Prostate


Microarray-based data mining reveals key genes and potential therapeutic drugs for Cadmium-induced prostate cell malignant transformation.

Environ Toxicol Pharmacol 2019 Mar 15;68:141-147. Epub 2019 Mar 15.

Institute of Cancer, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China. Electronic address:

Increasing evidence showed that Cadmium (Cd) can accumulate in the body and damage cells, resulting in cancerigenesis of the prostate with complex mechanisms. In the present study, we aimed to explore the possible key genes, pathways and therapeutic drugs using bioinformatics methods. Microarray-based data were retrieved and analyzed to screen differentially expressed genes (DEGs) between Cd-treated prostate cells and controls. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.014DOI Listing

miR-363 acts as a tumor suppressor in osteosarcoma cells by inhibiting PDZD2.

Oncol Rep 2019 Mar 19. Epub 2019 Mar 19.

Department of Orthopedic, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

PDZ domain containing 2 (PDZD2) is a multi-PDZ domain protein that promotes the proliferation of insulinoma cells, and is upregulated during prostate tumorigenesis. However, the function of PDZD2 in other cancers, including osteosarcoma (OS), remains unclear. Dysregulation of microRNAs (miRNAs) contributes to tumor initiation, proliferation and metastasis, via the regulation of their target genes. Read More

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http://dx.doi.org/10.3892/or.2019.7078DOI Listing

MicroRNA‑9 suppresses human prostate cancer cell viability, invasion and migration via modulation of mitogen‑activated protein kinase kinase kinase 3 expression.

Mol Med Rep 2019 Mar 21. Epub 2019 Mar 21.

Department of Urology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.

MicroRNAs (miRs) are small non‑coding RNA molecules that regulate gene expression at the post‑transcriptional level. Aberrant expression of miR‑9 has been reported to be involved in the tumorigenesis and progression of various malignancies. However, its role in prostate cancer (PC) has not been completely clarified. Read More

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http://dx.doi.org/10.3892/mmr.2019.10065DOI Listing

Metformin use and prostate cancer risk: A meta-analysis of cohort studies.

Medicine (Baltimore) 2019 Mar;98(12):e14955

Background: The relationship between metformin use and the risk of prostate cancer is still inconclusive. Therefore, we performed a systematic review and meta-analysis of all eligible cohort studies to evaluate a potential association of metformin use with prostate cancer risk.

Methods: A comprehensive literature search was performed in PubMed and Web of Science databases through July 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000014955DOI Listing

A prospective randomized trial of povidone-iodine suppository before transrectal ultrasonography-guided prostate biopsy.

Medicine (Baltimore) 2019 Mar;98(12):e14854

Department of Urology.

Objectives: To investigate a way to reduce infectious complication after transrectal ultrasonography-guided prostate biopsy (TRUS-Bx), we planned a randomized trial to determine whether the use of the povidone-iodine suppository is effective in preventing infectious complications.

Methods: This study prospectively assessed 250 patients who underwent TRUS-Bx during December 2014 and May 2016. Clinical questionnaire responses and safety were evaluated. Read More

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http://dx.doi.org/10.1097/MD.0000000000014854DOI Listing

Repurposed Drugs for Prostate Cancer.

Cancer J 2019 Mar/Apr;25(2):121-126

From the Division of Oncology, Beth Israel Deaconess Medical Center, Boston, MA.

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http://dx.doi.org/10.1097/PPO.0000000000000362DOI Listing

Re: The Institutional Learning Curve of Magnetic Resonance Imaging-Ultrasound Fusion Targeted Prostate Biopsy: Temporal Improvements in Cancer Detection in 4 Years

J Urol 2019 Feb 12:101097JU0000000000000173. Epub 2019 Feb 12.

Riverwalk Surgery , Bakersfield , California.

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http://dx.doi.org/10.1097/JU.0000000000000173DOI Listing
February 2019

Understanding PIM-1 kinase inhibitor interactions with free energy simulation.

Phys Chem Chem Phys 2019 Mar 21. Epub 2019 Mar 21.

State Key Laboratory of Precision Spectroscopy, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China and Computational Biomedicine (IAS-5/INM-9), Forschungszentrum Jülich, Jülich 52425, Germany.

The proviral integration site of the Moloney leukemia virus (PIM) family includes three homologous members. PIM-1 kinase is an important target in effective therapeutic interventions of lymphomas, prostate cancer and leukemia. In the current work, we performed free energy calculations to calculate the binding affinities of several inhibitors targeting this protein. Read More

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http://dx.doi.org/10.1039/c9cp00070dDOI Listing

The association between allergic diseases and cancer: a systematic review of the literature.

Neth J Med 2019 Feb;77(2):42-66

Department of Internal Medicine, Section Allergy and Clinical Immunology, Erasmus Medical Center Rotterdam, the Netherlands.

Introduction: Atopic syndrome (allergic rhinitis, asthma and eczema) and food allergies are frequently reported, especially in developed countries. Studies have previously suggested an inverse association between allergic diseases and cancer. The aim of this study was to investigate the association between allergic diseases and different types of cancers by performing a systematic review of the literature. Read More

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February 2019

Robot assisted laparoscopic prostatectomy in liver transplant recipient.

Minerva Urol Nefrol 2019 Mar 18. Epub 2019 Mar 18.

Division of Urology, Virginia Commonwealth University Health System, Richmond, VA, USA.

Robotic assisted laparoscopic prostatectomy (RALP) in liver transplant recipients (LTRs) is not well documented. We present two cases of RALP in LTRs with localized prostate cancer (PCa). In both cases, a transperitoneal approach was used, and they were successfully completed without perioperative complications. Read More

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http://dx.doi.org/10.23736/S0393-2249.19.03334-4DOI Listing

The Emerging Role of Voltage-Gated Sodium Channels in Tumor Biology.

Front Oncol 2019 6;9:124. Epub 2019 Mar 6.

Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Voltage-gated sodium channels (VGSCs) are transmembrane proteins which function as gates that control the flux of ions across the cell membrane. They are key ion channels for action potentials in excitable tissues and have important physiological functions. Abnormal function of VGSCs will lead to dysfunction of the body and trigger a variety of diseases. Read More

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http://dx.doi.org/10.3389/fonc.2019.00124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414428PMC

Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate.

Prostate Cancer Prostatic Dis 2019 Mar 20. Epub 2019 Mar 20.

Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.

Background: Voltage-gated Na channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a clinically used VGSC inhibitor/anti-anginal drug, which has been shown previously to inhibit breast cancer metastasis in vivo.

Methods: Using the Dunning model of rat PCa, the effect of ranolazine applied systemically (by gavage) was tested on the development of primary tumours and metastases following subcutaneous inoculation of Mat-LyLu cells into Copenhagen rats. Read More

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http://dx.doi.org/10.1038/s41391-019-0128-3DOI Listing

What is the most effective local anesthesia for transrectal ultrasonography-guided biopsy of the prostate? A systematic review and network meta-analysis of 47 randomized clinical trials.

Sci Rep 2019 Mar 20;9(1):4901. Epub 2019 Mar 20.

Department of Urology, Gangnam Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

We aimed to compare the effectiveness of various local anesthetic methods for controlling prostate biopsy (PBx) related pain using network meta-analysis. Literature searches were performed on PubMed/Medline, Embase, and Cochrane Library up to March 2018. Forty-seven randomized controlled trials, in which the effectiveness of PBx-related pain was investigated using a visual analogue scale after various local anesthetic methods, were included. Read More

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http://dx.doi.org/10.1038/s41598-019-41412-wDOI Listing

Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer.

Sci Transl Med 2019 Mar;11(484)

Division of Medical Oncology, Weill Cornell Medicine, New York, NY 10065, USA.

Histologic transformation to small cell neuroendocrine prostate cancer occurs in a subset of patients with advanced prostate cancer as a mechanism of treatment resistance. Rovalpituzumab tesirine (SC16LD6.5) is an antibody-drug conjugate that targets delta-like protein 3 (DLL3) and was initially developed for small cell lung cancer. Read More

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http://dx.doi.org/10.1126/scitranslmed.aav0891DOI Listing
March 2019
15.843 Impact Factor

Human GPRC6A mediates testosterone-induced ERK and mTORC1 signaling in prostate cancer cells.

Mol Pharmacol 2019 Mar 20. Epub 2019 Mar 20.

UTHSC.

GPRC6A is activated by testosterone and modulates prostate cancer (PCa) progression. Most humans have a GPRC6A variant that contains a recently evolved KGKY insertion/deletion in the third intracellular loop (ICL3) (designated GPRC6AICL3_KGKY) that replaces the ancestral KGRKLP sequence (GPRC6AICL3_RKLP) present in all other species. In vitro assays purport that human GPRC6AICL3_KGKY is retained intracellularly and lacks function. Read More

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http://dx.doi.org/10.1124/mol.118.115014DOI Listing

Comprehensive analysis of individual variation in the urinary proteome revealed significant gender differences.

Mol Cell Proteomics 2019 Mar 20. Epub 2019 Mar 20.

Beijing Normal University, Gene Engineering and Biotechnology Beijing Key Laboratory, China.

Disease biomarkers are the measurable changes associated with a pathophysiological process. Without homeostatic control, urine accumulates systematic changes in the body. Thus, urine is an attractive biological material for the discovery of disease biomarkers. Read More

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http://dx.doi.org/10.1074/mcp.RA119.001343DOI Listing

Prostate Cancer Responds to Anti-PD-1-CTLA4 Combo.

Authors:

Cancer Discov 2019 Mar 20. Epub 2019 Mar 20.

Combining nivolumab and ipilimumab may be an effective treatment strategy for metastatic castration-resistant prostate cancer. In a phase II trial, 25% of patients who received the combination following hormone therapy had an objective response. However, the combination was associated with considerable side effects that caused many patients to discontinue treatment. Read More

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http://dx.doi.org/10.1158/2159-8290.CD-NB2019-039DOI Listing

Advance In-silico based Predictive In-Vivo Profiling of Novel Potent β-Glucuronidase Inhibitors.

Authors:
Maria Yousuf

Curr Cancer Drug Targets 2019 Mar 19. Epub 2019 Mar 19.

Dow College of Biotechnology, Department of Bioinformatics, Dow University of Health Sciences Karachi. Pakistan.

Background: Intestinal β-glucuronidase enzyme has significant importance in colorectal carcinogenesis. Specific inhibition of the enzyme helps to prevent immune reactivation of the glucuronide-carcinogens thus, protects the intestine from ROS (Reactive Oxidative Species) mediatedcarcinogenesis.

Objectives: Advancements to the In-silico based techniques is providing broad range of studies to facilitate the drug designing and development process speedily through SwissADME and BOIELD-Eggtools. Read More

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http://dx.doi.org/10.2174/1568009619666190320102238DOI Listing

Stereotactic Body Radiotherapy - Current Indications.

Klin Onkol 2019 ;32(1):10-24

Background: Stereotactic body radiotherapy (SBRT) is used to treat localized tumor lesions and consists of applying high doses of radiation to a small number of fractions using specially equipped linear accelerators, modern immobilization devices, and imaging methods, which are considered special, advanced techniques in modern day radiotherapy. SBRT is a very well tolerated, non-invasive, short-term treatment that does not require hospitalization or any complicated preparation. Compared to standard radiotherapy techniques, SBRT allows, due to its precision, significantly higher doses to be applied to the target with less damage to surrounding healthy tissues. Read More

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http://dx.doi.org/10.14735/amko201910DOI Listing
January 2019

Glycans as Biomarkers in Prostate Cancer.

Int J Mol Sci 2019 Mar 19;20(6). Epub 2019 Mar 19.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.

Prostate cancer is the most commonly diagnosed malignancy in men, claiming over350,000 lives worldwide annually. Current diagnosis relies on prostate-specific antigen (PSA)testing, but this misses some aggressive tumours, and leads to the overtreatment of non-harmfuldisease. Hence, there is an urgent unmet clinical need to identify new diagnostic and prognosticbiomarkers. Read More

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http://dx.doi.org/10.3390/ijms20061389DOI Listing

Biological Activity and In Silico Study of 3-Modified Derivatives of Betulin and Betulinic Aldehyde.

Int J Mol Sci 2019 Mar 19;20(6). Epub 2019 Mar 19.

Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Organic Chemistry, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland.

A series of 3-substituted derivatives of betulin and betulinic aldehyde were synthesized as promising anticancer agents. The newly triterpenes were tested against five human cancer cell lines like biphenotypic B myelomonocytic leukaemia (MV-4-11), adenocarcinoma (A549), prostate (Du-145), melanoma (Hs294T), breast adenocarcinoma (MCF-7) and normal human mammary gland (MCF-10A). The compound showed towards Du-145, MCF-7 and Hs294T cells significant antiproliferative activity with IC ranging from 7. Read More

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http://dx.doi.org/10.3390/ijms20061372DOI Listing

Isoflavones.

Molecules 2019 Mar 19;24(6). Epub 2019 Mar 19.

Department of Biochemistry, Faculty of Science, Masaryk University, Kotlarska 2, 61137 Brno, Czech Republic.

Phytoestrogens are naturally occurring nonsteroidal phenolic plant compounds that, due to their molecular structure and size, resemble vertebrate steroids estrogens. This review is focused on plant flavonoids isoflavones, which are ranked among the most estrogenic compounds. The main dietary sources of isoflavones for humans are soybean and soybean products, which contain mainly daidzein and genistein. Read More

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http://dx.doi.org/10.3390/molecules24061076DOI Listing

Focal Neuroendocrine Differentiation of Conventional Prostate Adenocarcinoma as a Prognostic Factor after Radical Prostatectomy: A Systematic Review and Meta-Analysis.

Int J Mol Sci 2019 Mar 19;20(6). Epub 2019 Mar 19.

Institute for Urology and Reproductive Health, Sechenov University, Moscow 119991, Russia.

The biologic and prognostic value of focal neuroendocrine differentiation (NED) in conventional prostate adenocarcinoma (PC) patients who undergo radical prostatectomy (RP) remains controversial. In this systematic review and meta-analysis, we assessed the association of focal NED in conventional PC with oncological outcomes after RP. A literature search using PubMed, Scopus, Web of Science, and Cochrane Library was conducted on December 2018 to find relevant studies according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Read More

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http://dx.doi.org/10.3390/ijms20061374DOI Listing

[Discussion of correlation between histogram analysis of quantitative diffusion weighted imaging and Gleason score of prostate cancer].

Zhonghua Yi Xue Za Zhi 2019 Mar;99(11):823-828

Department of Radiology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

To discuss the correlation between histogram analysis of quantitative mono-exponential, bi-exponential and diffusion kurtosis models in diffusion weighted imaging and the Gleason score of prostate cancer, and evaluate the application value and diagnostic efficiency in identifying low and high grade prostate cancer. A total of 50 patients with histologically confirmed as prostate cancer were examined from May 2015 to May 2016 in the Second Affiliated Hospital of Soochow University using DWI performed at 3.0 T with an extended b-value range from 0 to 2 000 s/mm(2). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.11.005DOI Listing

Is Intravesical Prostatic Protrusion a Risk Factor for Hydronephrosis and Renal Insufficiency in Benign Prostate Hyperplasia Patients.

J Chin Med Assoc 2019 Mar 11. Epub 2019 Mar 11.

Department of Urology, Taipei Veterans General Hospital, Taiwan, ROC.

Background: Some patients with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) hesitate to undergo surgical treatment until acute urinary retention (AUR) occurs. Some of these patients have been found to have hydronephrosis or even renal insufficiency. This study aimed to analyze the risk factors for hydronephrosis in patients with AUR who needed to receive transurethral resection of the prostate (TURP). Read More

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http://Insights.ovid.com/crossref?an=02118582-900000000-9997
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http://dx.doi.org/10.1097/JCMA.0000000000000088DOI Listing
March 2019
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The evolving role of diet in prostate cancer risk and progression.

Curr Opin Oncol 2019 Mar 15. Epub 2019 Mar 15.

Department of Family and Community Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Purpose Of Review: This overview examines the rationale for dietary interventions for prostate cancer by summarizing the current evidence base and biological mechanisms for the involvement of diet in disease incidence and progression.

Recent Findings: Recent data have further solidified the association between insulin resistance and prostate cancer with the homeostatic model assessment of insulin resistance. Data also show that periprostatic adipocytes promote extracapsular extension of prostate cancer through chemokines, thereby providing a mechanistic explanation for the association observed between obesity and high-grade cancer. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000519DOI Listing

Targeting the androgen receptor and overcoming resistance in prostate cancer.

Curr Opin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Purpose Of Review: Prostate cancer (PCa) is diagnosed in one out of every nine men and is the second leading cause of cancer death among men. Although therapies targeting the androgen receptor (AR) are highly effective, development of resistance is universal and remains a major therapeutic challenge. Nonetheless, signaling via AR is frequently maintained despite standard androgen-signaling inhibition. Read More

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http://Insights.ovid.com/crossref?an=00001622-900000000-9919
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http://dx.doi.org/10.1097/CCO.0000000000000520DOI Listing
March 2019
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Endocrine Disrupting-Chemicals and Biochemical Recurrence of Prostate Cancer after Prostatectomy: A cohort study in Guadeloupe (French West Indies).

Int J Cancer 2019 Mar 20. Epub 2019 Mar 20.

CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-97110 Pointe-à-Pitre, France.

Previous studies have suggested that exposure to environmental chemicals with hormonal properties, also called endocrine disrupting chemicals, may be involved in the occurrence of prostate cancer. Such exposure may also influence the treatment outcome as it is still present at the time of diagnosis, the beginning of therapy, and beyond. We followed 326 men in Guadeloupe (French West Indies) who underwent radical prostatectomy as primary treatment of localized prostate cancer. Read More

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http://dx.doi.org/10.1002/ijc.32287DOI Listing

The Transcription Factor ERG Regulates Super-Enhancers Associated with an Endothelial-Specific Gene Expression Program.

Circ Res 2019 Mar 20. Epub 2019 Mar 20.

National Heart and Lung Institute, Vascular Sciences, Imperial College London.

Rationale: The ETS transcription factor (TF) ERG is essential for endothelial homeostasis, driving expression of lineage genes and repressing pro-inflammatory genes. Loss of ERG expression is associated with diseases including atherosclerosis. ERG's homeostatic function is lineage-specific, since aberrant ERG expression in cancer is oncogenic. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313788DOI Listing

Overexpression of lncRNA GAS5 suppresses prostatic epithelial cell proliferation by regulating COX-2 in chronic non-bacterial prostatitis.

Cell Cycle 2019 Mar 20. Epub 2019 Mar 20.

a Department of Urology , The First Affiliated Hospital of Soochow University , Suzhou 215006 , Jiangsu , China.

Background: Chronic non-bacterial prostatitis (CNP) is a common urologic disease that is linked to the development of prostate cancer. Long non-coding RNA (lncRNA) GAS5 has been identified to mediate cell proliferation in prostate cancer, although its role in CNP is still unclear.

Methods: Human prostate epithelial cell line RWPE-1 was induced by lipopolysaccharide (LPS) to mimic CNP model in vitro. Read More

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https://www.tandfonline.com/doi/full/10.1080/15384101.2019.1
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http://dx.doi.org/10.1080/15384101.2019.1593644DOI Listing
March 2019
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Robotic surgery research in urology - a bibliometric analysis of field and top 100 articles.

J Endourol 2019 Mar 20. Epub 2019 Mar 20.

Westmead Hospital, 8539, Urology, Westmead, New South Wales, Australia.

Introduction: There has been a surge in robotic surgery research publications over the past 20 years. However, to date there has been no characterisation of urology's contribution to the robotic field, and there is a lack of bibliometric literature to guide future investigation. We conducted this bibliometric analysis to characterise the distributions and characteristics of robotic surgery research in the urological field, with sub-analysis of the top 100 articles. Read More

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http://dx.doi.org/10.1089/end.2018.0866DOI Listing

Open-Top Light-Sheet Microscopy Image Atlas of Prostate Core Needle Biopsies.

Arch Pathol Lab Med 2019 Mar 20. Epub 2019 Mar 20.

From the Departments of Pathology (Drs Reder, True, and Liu and Ms McCarty) and Mechanical Engineering (Drs Glaser and Liu and Mr Chen), University of Washington, Seattle.

Context.—: Ex vivo microscopy encompasses a range of techniques to examine fresh or fixed tissue with microscopic resolution, eliminating the need to embed the tissue in paraffin or produce a glass slide. One such technique is light-sheet microscopy, which enables rapid 3D imaging. Read More

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http://dx.doi.org/10.5858/arpa.2018-0466-OADOI Listing

What is Moses effect: an historical perspective.

J Endourol 2019 Mar 20. Epub 2019 Mar 20.

Paris, France ;

Introduction and objectives The Moses effect (ME) was described more than 30 years ago during normal laser functioning in a fluid medium. Recently, a laser device equipped with a pulse-modulating system called MosesTM technology (MT, Lumenis®) was marketed for both stone lithotripsy and prostate endoscopic surgery. We aimed to perform a literature revision of Moses effect from an historical perspective up until its present-day applications. Read More

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http://dx.doi.org/10.1089/end.2019.0012DOI Listing

Is Socioeconomic Advantage Associated With Positive Health Behaviors and Health Outcomes Among Asian Indians?

Health Serv Res Manag Epidemiol 2019 Jan-Dec;6:2333392819830371. Epub 2019 Mar 13.

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Objective: The South Asian Health Needs Assessment was conducted to collect health status information on the rapidly growing Asian Indian (AI) community in the Houston area. Many were highly educated and reported high income levels, factors usually associated with better health outcomes. This study examined the relationship between socioeconomic advantage and the health behaviors and health outcomes of AIs. Read More

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http://dx.doi.org/10.1177/2333392819830371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416674PMC

Detrusorrhaphy during Robot-Assisted Radical Prostatectomy: Early Recovery of Urinary Continence and Surgical Technique.

Biomed Res Int 2019 12;2019:1528142. Epub 2019 Feb 12.

Department of Urology, Hallym University Sacred Heart Hospital, Hallym University, College of Medicine, Anyang, Republic of Korea.

Robot-assisted radical prostatectomy (RARP) has largely replaced open radical prostatectomy as the standard surgical treatment for prostate cancer. However, postoperative urinary incontinence still persists and has a significant impact on quality of life. We report the superior results of the detrusorrhaphy technique during RARP that helps achieve early continence. Read More

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http://dx.doi.org/10.1155/2019/1528142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390270PMC
February 2019

Comparative Diagnostic Accuracy of Contrast-Enhanced Ultrasound and Shear Wave Elastography in Differentiating Benign and Malignant Lesions: A Network Meta-Analysis.

Front Oncol 2019 5;9:102. Epub 2019 Mar 5.

Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

We performed a network meta-analysis to compare the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) and shear wave elastography (SWE) in differentiating benign and malignant lesions in different body sites. A computerized literature search of Medline, Embase, SCOPUS, and Web of Science was performed using relevant keywords. Following data extraction, we calculated sensitivity, specificity, positive likelihood ratio (LR), negative LR, and diagnostic odds ratio (DOR) for CEUS, and SWE compared to histopathology as a reference standard. Read More

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http://dx.doi.org/10.3389/fonc.2019.00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412152PMC

Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography.

Biomed Opt Express 2019 Mar 22;10(3):1405-1419. Epub 2019 Feb 22.

Department of Electrical and Computer Engineering, Boston University, 8 St. Mary's Street, Boston, MA 02215, USA.

Current diagnosis of prostate cancer relies on histological analysis of tissue samples acquired by biopsy, which could benefit from real-time identification of suspicious lesions. Photoacoustic tomography has the potential to provide real-time targets for prostate biopsy guidance with chemical selectivity, but light delivered from the rectal cavity has been unable to penetrate to the anterior prostate. To overcome this barrier, a urethral device with cylindrical illumination is developed for whole-prostate imaging, and its performance as a function of angular light coupling is evaluated with a prostate-mimicking phantom. Read More

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http://dx.doi.org/10.1364/BOE.10.001405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420282PMC

Prostate cancer recurrence presenting as an isolated small bowel tumour.

J Surg Case Rep 2019 Mar 14;2019(3):rjz065. Epub 2019 Mar 14.

Dandenong Hospital, Monash Health, Department of Colorectal Surgery.

Prostate cancer is the most commonly diagnosed cancer in males and third most common cause of cancer deaths in Australia. With improved survival rates and increasing reports of metastatic disease, we can expect to see more interesting and unusual presentations of recurrent disease. We present the case of a 66-year-old male with a prostate cancer recurrence to small bowel after curative treatment. Read More

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http://dx.doi.org/10.1093/jscr/rjz065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416823PMC

Research Progress on PARP14 as a Drug Target.

Front Pharmacol 2019 5;10:172. Epub 2019 Mar 5.

Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Shaanxi Key Laboratory of Brain disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.

Poly-adenosine diphosphate-ribose polymerase (PARP) implements posttranslational mono- or poly-ADP-ribosylation modification of target proteins. Among the known 18 members in the enormous family of PARP enzymes, several investigations about PARP1, PARP2, and PARP5a/5b have been launched in the past few decades; more specifically, PARP14 is gradually emerging as a promising drug target. An intact PARP14 (also named ARTD8 or BAL2) is constructed by macro1, macro2, macro3, WWE, and the catalytic domain. Read More

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http://dx.doi.org/10.3389/fphar.2019.00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411704PMC

Transcriptomics Signature from Next-Generation Sequencing Data Reveals New Transcriptomic Biomarkers Related to Prostate Cancer.

Cancer Inform 2019 13;18:1176935119835522. Epub 2019 Mar 13.

School of Computer Science, University of Windsor, Windsor, ON, Canada.

Prostate cancer is one of the most common types of cancer among Canadian men. Next-generation sequencing using RNA-Seq provides large amounts of data that may reveal novel and informative biomarkers. We introduce a method that uses machine learning techniques to identify transcripts that correlate with prostate cancer development and progression. Read More

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http://dx.doi.org/10.1177/1176935119835522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416685PMC

Serious adverse events in African-American cancer patients with sickle cell trait and inherited haemoglobinopathies in a SEER-Medicare claims cohort.

Br J Cancer 2019 Mar 20. Epub 2019 Mar 20.

Department of Community Medicine and Health Care, UConn School of Medicine, Farmington, CT, USA.

African-American (AA) cancer patients have long-experienced worse outcomes compared to non-Hispanic whites (NHW). No studies to date have evaluated the prognostic impact of sickle cell trait (SCT) and other inherited haemoglobinopathies, of which several are disproportionately high in the AA population. In a cohort analysis of treated patients diagnosed with breast or prostate cancer in the linked SEER-Medicare database, the relative risk (RR) for ≥1 serious adverse events (AEs), defined as hospitalisations or emergency department visits, was estimated for 371 AA patients with a haemoglobinopathy (AA+) compared to patients without haemoglobinopathies (17,303 AA-; 144,863 NHW-). Read More

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http://www.nature.com/articles/s41416-019-0416-7
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http://dx.doi.org/10.1038/s41416-019-0416-7DOI Listing
March 2019
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Association of prostate cancer SLCO gene expression with Gleason grade and alterations following androgen deprivation therapy.

Prostate Cancer Prostatic Dis 2019 Mar 19. Epub 2019 Mar 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: SLCO-encoded transporters have been associated with progression to castration-resistant prostate cancer (CRPC) after initiation of androgen deprivation therapy (ADT). Although expressed at lower levels than in CRPC tissues, SLCO-encoded transporters may also play a role in response of primary prostate cancer (PCa) to ADT and biochemical recurrence.

Methods: We systematically explored expression of the 11 human SLCO genes in a large sample of untreated and ADT-treated normal prostate (NP) and primary PCa tissues, including tumors treated with neoadjuvant abiraterone. Read More

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http://dx.doi.org/10.1038/s41391-019-0141-6DOI Listing

Sex hormones and anticancer immunity.

Clin Cancer Res 2019 Mar 19. Epub 2019 Mar 19.

Department of Biochemistry, University of Lausanne.

The impact of sex hormones on anticancer immunity deserves attention due to the importance of the immune system in cancer therapy and the recognition of sex differences in immunity. Cancer is ultimately the result of failed immune surveillance and diverging effects of male and female sex hormones on anticancer immunity could contribute to the higher cancer incidence and poorer outcome in men. Estrogens and androgens affect the number and function of immune cells, an effect that depends on cell type, tumor microenvironment, and the age and reproductive status of the individual. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0137DOI Listing

A multicentre prospective clinical trial of Gallium PSMA HBED-CC PET-CT restaging in biochemically relapsed prostate carcinoma: Oligometastatic rate and distribution, compared to standard imaging.

Int J Radiat Oncol Biol Phys 2019 Mar 16. Epub 2019 Mar 16.

Molecular Imaging and Therapy Service (Nuclear Medicine), Royal Perth Hospital and Fiona Stanley Hospital, Perth, Australia; Medical Engineering and Physics, Royal Perth Hospital and Fiona Stanley Hospital, Perth, Australia.

Aim: This study is to assess the utility ofGallium PSMA HBED-CC PET/CT (PSMA-HBED), compared to standard imaging, in the detection of recurrent prostate carcinoma in patients with biochemical relapse, to determine the prevalence of oligometastatic disease recurrence and its distribution.

Method: This is a prospective, multicentre clinical trial of PSMA-HBED PET/CT imaging in patients with early biochemical relapse of prostate carcinoma (PCa) (median PSA 2.55ng/ml) following definitive prostatectomy (152 patients) or radiotherapy (86 patients) with either no lesions or oligometastatic disease on abdominopelvic CT (CT) and bone scan (BS). Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.03.014DOI Listing

Automatic segmentation of the prostate on CT images using deep neural networks (DNN).

Int J Radiat Oncol Biol Phys 2019 Mar 16. Epub 2019 Mar 16.

Department of Radiation Oncology, Josephine Ford Cancer Institute, Henry Ford Health System, Detroit, MI.

Purpose: Recent advances in deep neural networks (DNN) have unlocked opportunities toward its application for automatic image segmentation. We have evaluated a DNN-based algorithm for automatic segmentation of the prostate gland on a large cohort of patient images.

Materials And Methods: Planning-CT (pCT) datasets for 1114 prostate cancer patients were retrospectively selected and divided into 2 groups. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.03.017DOI Listing

TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells.

Cell Signal 2019 Mar 16. Epub 2019 Mar 16.

Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences and Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Transmembrane prostate androgen-induced protein (TMEPAI) is a type I transmembrane protein induced by several intracellular signaling pathways such as androgen, TGF-β, EGF, and Wnt signaling. It has been reported that TMEPAI functions to suppress TGF-β and androgen signaling but here, we report a novel function of TMEPAI in Wnt signaling suppression. First, we show that TMEPAI significantly inhibits TCF/LEF transcriptional activity stimulated by Wnt3A, LiCl, and β-catenin. Read More

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http://dx.doi.org/10.1016/j.cellsig.2019.03.016DOI Listing

Permanent prostate brachytherapy is safe in men with severe baseline lower urinary tract symptoms.

Brachytherapy 2019 Mar 16. Epub 2019 Mar 16.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Purpose: To evaluate the long-term urinary outcomes of men with severe pretreatment lower urinary tract symptoms (LUTS) treated with permanent prostate brachytherapy (PPB) ± external beam radiation therapy for localized prostate cancer.

Methods And Materials: A total of 105 men with International Prostate Symptom Score (IPSS) 20-35 before PPB were categorized by IPSS change at last followup: (1) worse = IPSS rise >3; (2) no change = IPSS change within three points of baseline; (3) improved = IPSS fall by >3 points. We then evaluated patients who worsened vs. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.02.002DOI Listing

Silica-Coated Gold Nanorods with High Photothermal Efficiency and Biocompatibility as a Contrast Agent for Terahertz Imaging.

J Biomed Nanotechnol 2019 May;15(5):910-920

The application of terahertz imaging in biomedical diagnostics is limited by the poor imaging contrast due to the strong absorption of terahertz waves by water molecules in the living body. To resolve this problem, gold nanorods (GNRs) have been considered as a possible contrast agent. However, the conventional preparation of GNRs requires using cetyltrimethylammonium bromide (CTAB) as a stabilizing surfactant, which is toxic to animals at high exposures. Read More

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https://www.ingentaconnect.com/content/10.1166/jbn.2019.2738
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http://dx.doi.org/10.1166/jbn.2019.2738DOI Listing
May 2019
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Is digital rectal examination still useful in prostate cancer diagnosis? NO!

Authors:
A Totaro

Urologia 2019 Feb;86(1):32-33

Department of Urology, "Agostino Gemelli" Academic Hospital Foundation, IRCCS, Catholic University School of Medicine, Rome, Italy.

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http://dx.doi.org/10.1177/0391560319834462DOI Listing
February 2019

Is digital rectal examination still useful in prostate cancer diagnosis? YES!

Urologia 2019 Feb;86(1):34

U.O. Urologia - Azienda Ospedaliera Padova, Padua, Italy.

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http://dx.doi.org/10.1177/0391560319834463DOI Listing
February 2019