195,739 results match your criteria Prostate


Simple structural indocyanine green-loaded microbubbles for dual-modality imaging and multi-synergistic photothermal therapy in prostate cancer.

Nanomedicine 2020 Jun 2:102229. Epub 2020 Jun 2.

Department of Medical Ultrasonic, Laboratory of Novel Optoacoustic (Ultrasonic) imaging, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. Electronic address:

As problems with the overuse of radical prostate cancer (PCa) treatment are increasingly exposed, focal therapy represents the direction of low- or intermediate-risk PCa management in the future. However, inaccurate diagnosis and low controllability of focal therapy hinders its clinical translation. In this study, we develop simple structural cyclic arginine-glycine-aspartic (cRGD) peptide-modified and indocyanine green (ICG)-loaded microbubbles (cRGD-ICG-MBs) for ultrasound-photoacoustic imaging and multi-synergistic photothermal therapy (PTT) to address the above problems. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102229DOI Listing

Effects of castration on atherosclerosis in Yucatan minipigs with genetic hypercholesterolemia.

PLoS One 2020 5;15(6):e0234131. Epub 2020 Jun 5.

Department of Clinical Medicine, Heart Diseases, Aarhus University, Aarhus, Denmark.

Background: Low plasma testosterone, either spontaneous or as a result of androgen deprivation therapy for prostate cancer, is associated with an increased risk of cardiovascular events. The underlying mechanism in humans is not understood. Experimental studies in mice have shown that castration facilitates atherogenesis and may increase signs of plaque vulnerability. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234131PLOS

Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity.

PLoS One 2020 5;15(6):e0233846. Epub 2020 Jun 5.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, New South Wales, Australia.

Growth Differentiation Factor-15 (GDF15) is a divergent TGF-beta superfamily cytokine that is overexpressed by most cancers and is induced by anticancer therapy. Transgenic and induced animal models suggest that it protects from cancer development but the mechanisms are uncertain. We investigated the role of immunity in GDF15 induced reduction in prostate cancer (PCa) growth. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233846PLOS

Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms: STROBE, a case-control study.

Medicine (Baltimore) 2020 Jun;99(23):e20546

Department of Urology, Myongji Hospital, Hanyang University College of Medicine, Goyang.

Erectile dysfunction (ED) and depression are closely related. We sought to determine ED and depression were improved by tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, at 5 mg daily, in this case-control study.Participants were men aged 20 to 65 years with ED for >3 months, International Index of Erectile Function-5 (IIEF) score <21 points, and Zung Self-Rating Depression Scale (SDS) survey result >50 points who were willing to participate. Read More

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http://dx.doi.org/10.1097/MD.0000000000020546DOI Listing

Forensic Autopsies can Determine Latent Prostate Cancer Prevalence.

J Forensic Sci 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, 520-2192, Japan.

To evaluate the usefulness of forensic autopsies in determining latent prostate cancer (PC) prevalence, we examined latent PC prevalence from autopsies and compared our findings between decedents with and without cancer. Data from forensic autopsies performed in Japan from 2004 to 2014 were obtained. For each prostate, histopathological examinations were performed in both the base and the apex sections. Read More

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http://dx.doi.org/10.1111/1556-4029.14472DOI Listing

Prognostic factors influencing overall survival in de novo oligometastatic prostate cancer patients.

Prostate 2020 Jun 5. Epub 2020 Jun 5.

Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: Oligometastatic cancer has been suggested as an intermediate state between localized disease and wide-ranging metastases. The clinical significance of local treatment in oligometastatic prostate cancer (PCa) has been a recent topic of interest. However, standard definitions of oligometastasis are lacking. Read More

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http://dx.doi.org/10.1002/pros.24016DOI Listing

Stereotactic Body Radiotherapy for Prostate Cancer.

Am J Mens Health 2020 May-Jun;14(3):1557988320927241

Department of Radiation Oncology, University of California, Los Angeles, USA.

Prostate cancer remains the most common and second most deadly cancer diagnosed amongst U.S. men. Read More

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http://dx.doi.org/10.1177/1557988320927241DOI Listing

Hematologic parameters are not predictors of upgrading or treatment in a racially diverse prospective study of men with prostate cancer on active surveillance.

Aging Male 2020 Jun 5:1-9. Epub 2020 Jun 5.

Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.

Neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) are useful clinical biomarkers for prognosis in several malignancies. Their predictive value has been less clearly demonstrated with prostate cancer (PCa), particularly, their utility within active surveillance (AS) protocols. We aim to evaluate NLR and PLR in AS patients. Read More

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http://dx.doi.org/10.1080/13685538.2020.1772227DOI Listing

Impact of bowel and rectum air on target dose with robustly optimized intensity-modulated proton therapy plans.

Acta Oncol 2020 Jun 5:1-7. Epub 2020 Jun 5.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.

Pelvic target dose from intensity-modulated proton therapy (IMPT) is sensitive to patient bowel motion. Robustly optimized plans in regard to bowel filling may improve the dose coverage in the treatment course. Our purpose is to investigate the effect of air volume in large and small bowel and rectum on target dose from IMPT plans. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1769859DOI Listing

Long-term health-related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer.

Cancer Med 2020 Jun 4. Epub 2020 Jun 4.

Faculty of Social Sciences/Health Sciences, Tampere University, Tampere, Finland.

Background: The long-term health-related quality of life (HRQOL) impacts of PCa screening have not been adequately evaluated. We aimed to compare the generic and disease-specific health-related quality of life (HRQOL) among men with prostate cancer in the screening arm with the control arm of the PSA-based prostate cancer screening trial in up to 15 years of follow-up.

Materials And Methods: This study was conducted within population-based Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC). Read More

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http://dx.doi.org/10.1002/cam4.3181DOI Listing

Geriatric 8 screening of frailty in patients with prostate cancer.

Int J Urol 2020 Jun 4. Epub 2020 Jun 4.

Departments of, Department of, Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Objectives: To evaluate the association between the score of the Geriatric 8 screening tool and treatment by disease stages in patients with prostate cancer.

Methods: Between January 2017 and June 2019, we prospectively evaluated the Geriatric 8 in 540 prostate cancer patients who were treated with robot-assisted radical prostatectomy, radiotherapy, androgen deprivation therapy alone and standard of care for metastatic hormone-naïve prostate cancer or castration-resistant prostate cancer. The primary purpose was the association between frailty (Geriatric 8 ≤14) and robot-assisted radical prostatectomy, radiotherapy, androgen deprivation therapy alone, and metastatic diseases. Read More

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http://dx.doi.org/10.1111/iju.14256DOI Listing

Predictive factors of rectal hemorrhage in patients with localized prostate cancer who underwent low-dose-rate brachytherapy.

Int J Clin Oncol 2020 Jun 5. Epub 2020 Jun 5.

Department of Urology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.

Background: This study aimed to evaluate the association between clinical covariates or the prescribed radiation dose for the prostate and rectal hemorrhage in patients with prostate cancer (PCa) who received iodine-125 low-dose-rate brachytherapy (LDR-BT group) or the combination of LDR-BT and external beam radiation therapy (CMT group).

Methods And Materials: In this retrospective study, we reviewed the clinical records of 298 consecutive PCa patients with clinical stage T1c/T2 who underwent LDR-BT between August 2004 and August 2016 at a single institution. The prescribed minimum peripheral doses were 145 Gy for the LDR-BT group and 104 Gy for the CMT group. Read More

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http://dx.doi.org/10.1007/s10147-020-01713-xDOI Listing

Predicting factors for progression to castration resistance prostate cancer after biochemical recurrence in patients with clinically localized prostate cancer who underwent radical prostatectomy.

Int J Clin Oncol 2020 Jun 4. Epub 2020 Jun 4.

Department of Urology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Background: To determine prognostic factors associated with progression to castration-resistant prostate cancer following biochemical recurrence which is lethal prostate cancer and establish a risk stratification model of progression to castration-resistant prostate cancer.

Methods: We retrospectively reviewed the data of 550 patients who experienced biochemical recurrence after radical prostatectomy. The endpoint of the present study was progression to castration-resistant prostate cancer. Read More

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http://dx.doi.org/10.1007/s10147-020-01716-8DOI Listing

Evaluation of a marker-less, intra-operative, augmented reality guidance system for robot-assisted laparoscopic radical prostatectomy.

Int J Comput Assist Radiol Surg 2020 Jun 5. Epub 2020 Jun 5.

Electrical and Computer Engineering, University of British Columbia, 2329 West Mall, Vancouver, BC, V6T 1Z4, Canada.

Purpose: Robot-assisted laparoscopic radical prostatectomy (RALRP) using the da Vinci surgical robot is a common treatment for organ-confined prostate cancer. Augmented reality (AR) can help during RALRP by showing the surgeon the location of anatomical structures and tumors from preoperative imaging. Previously, we proposed hand-eye and camera intrinsic matrix estimation procedures that can be carried out with conventional instruments within the patient during surgery, take < 3 min to perform, and fit seamlessly in the existing surgical workflow. Read More

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http://dx.doi.org/10.1007/s11548-020-02181-4DOI Listing

Hormonal prostate cancer therapies and cardiovascular disease: a systematic review.

Heart Fail Rev 2020 Jun 4. Epub 2020 Jun 4.

Clinical Oncology Unit, Istituto Neurotraumatologico Italiano (I.N.I.) Grottaferrata, via di S.Anna snc, Grottaferrata, 00046, Rome, Italy.

Therapeutic intervention for prostate cancer mostly relies on eliminating circulating androgen or antagonizing its effect at the cellular level. As the use of endocrine therapies grows, an under-reported incidence of cardiovascular toxicities occurs in prostate cancer patients. In this review, we summarize data of clinical studies, investigating the cardiovascular and metabolic alterations associated with the use of old and new endocrine drugs (gonadotropin-releasing hormone [GnRH] agonists and antagonists, androgen receptor inhibitors, 17α-hydroxylase/c-17,20-lyase [CYP17] inhibitor) in prostate cancer. Read More

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http://dx.doi.org/10.1007/s10741-020-09984-2DOI Listing

Surgical Management and Outcomes of Rectal Cancer with Synchronous Prostate Cancer: A Multicenter Experience from the GRECCAR Group.

Ann Surg Oncol 2020 Jun 4. Epub 2020 Jun 4.

Department of Digestive Surgical Oncology - Liver Transplantation Unit, University Hospital of Besançon, Besançon Cedex, France.

Background: Synchronous prostate cancer (PC) and rectal cancer (RC) is a rare clinical situation. While combining curative-intent management for both cancers can be challenging, available data for guiding the multidisciplinary strategy are lacking.

Methods: Consecutive patients undergoing rectal resection for a mid-low RC with synchronous PC treated at 9 tertiary-care centers between 2008 and 2018 were included. Read More

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http://dx.doi.org/10.1245/s10434-020-08683-4DOI Listing

A systematic scoping review of multidisciplinary cancer team and decision-making in the management of men with advanced prostate cancer.

World J Urol 2020 Jun 4. Epub 2020 Jun 4.

Department of Surgery, Austin Hospital, University of Melbourne, Melbourne, VIC, Australia.

Purpose: The early diagnosis of prostate cancer and subsequent access to the treatment options helps to achieve optimal cancer outcomes. As the treatment options for patients with advanced prostate cancer continues to evolve, patients need to access a multidisciplinary team (MDT) meeting to receive best-practice care.

Methods: In this paper a MEDLINE review was performed to assess clinical decision making in the context of MDT discussions for patients with advanced prostate cancer. Read More

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http://dx.doi.org/10.1007/s00345-020-03265-1DOI Listing

Real-World Outcomes in First-Line Treatment of Metastatic Castration-Resistant Prostate Cancer: The Prostate Cancer Registry.

Target Oncol 2020 Jun 4. Epub 2020 Jun 4.

Oncology Division, Hospital de Santa Maria, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-035, Lisbon, Portugal.

Background: Metastatic prostate cancer has a 30% 5-year survival rate despite recent therapeutic advances. There is a need to improve the clinical understanding and treatment of this disease, particularly in the real-world setting and among patients who are under-represented in clinical trials.

Objective: We aimed to evaluate the characteristics and clinical outcomes of patients who received their first treatment for metastatic castration-resistant prostate cancer (mCRPC) in routine clinical practice, independent of treatment used, including subgroups with baseline cardiac disease, diabetes mellitus, or visceral metastases. Read More

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http://dx.doi.org/10.1007/s11523-020-00720-2DOI Listing

FCGCNMDA: predicting miRNA-disease associations by applying fully connected graph convolutional networks.

Mol Genet Genomics 2020 Jun 4. Epub 2020 Jun 4.

School of Information and Electrical Engineering, Xuzhou University of Technology, Xuzhou, 221018, China.

Growing evidence indicates that the development and progression of multiple complex diseases are influenced by microRNA (miRNA). Identifying more miRNAs as biomarkers for clinical diagnosis, treatment and prognosis is vital to promote the development of bioinformatics and medicine. Considering that the traditional biological experimental methods are generally time-consuming and expensive, high-efficient computational methods are encouraged to uncover potential disease-related miRNAs. Read More

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http://dx.doi.org/10.1007/s00438-020-01693-7DOI Listing

Rectal gas-induced susceptibility artefacts on prostate diffusion-weighted MRI with epi read-out at 3.0 T: does a preparatory micro-enema improve image quality?

Abdom Radiol (NY) 2020 Jun 4. Epub 2020 Jun 4.

Institut und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Carl Gustav Carus Dresden, Fetscherstrasse 74, 01307, Dresden, Deutschland.

Purpose: To assess whether the application of a preparatory micro-enema reduces gas-induced susceptibility artefacts on diffusion-weighted MRI of the prostate.

Methods: 114 consecutive patients who received multiparametric 3 T MRI of the prostate at our institution were retrospectively enrolled. 63 patients self-administered a preparatory micro-enema prior to imaging, and 51 patients underwent MRI without bowel preparation. Read More

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http://dx.doi.org/10.1007/s00261-020-02600-9DOI Listing

Circular RNA HIPK3: A Key Circular RNA in a Variety of Human Cancers.

Front Oncol 2020 15;10:773. Epub 2020 May 15.

Hepatic Surgery Center, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

Circular RNAs (circRNAs), which act as initiators and promoters of various diseases, were thought to be mostly noncoding RNAs (ncRNAs) in eukaryotes, until recent studies confirmed that some circRNAs have the function of encoding proteins. Accumulating research findings have proved that dysregulation of circRNAs is associated with the developmental process of multiple cancers. circHIPK3, an example of circRNA, is frequently expressed in many diseases, such as diabetes, age-related cataract, idiopathic pulmonary fibrosis, preeclampsia, osteoblasts, and retinal vascular dysfunction, leading to disease development and progression. Read More

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http://dx.doi.org/10.3389/fonc.2020.00773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242753PMC

Insulin Growth Factor Binding Protein 7 (IGFBP7)-Related Cancer and IGFBP3 and IGFBP7 Crosstalk.

Front Oncol 2020 15;10:727. Epub 2020 May 15.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

The insulin/insulin-like growth factors (IGFs) have crucial tasks in the growth, differentiation, and proliferation of healthy and pernicious cells. They are involved in coordinated complexes, including receptors, ligands, binding proteins, and proteases. However, the systems can become dysregulated in tumorigenesis. Read More

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http://dx.doi.org/10.3389/fonc.2020.00727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242731PMC

Investigation of the association between metabolic syndrome and breast cancer patients.

Eur J Transl Myol 2020 Apr 1;30(1):8776. Epub 2020 Apr 1.

Department of Internal Medicine, School of Medicine, Hazrat-e Rasool Hospital, Iran University of Medical Sciences. Tehran, Iran.

One of the most serious cancers among women is breast cancer. This disease is the first reason for the death of women due to cancer. Increasing breast cancer risk may associate with many factors including genetic, reproductive factors, people's lifestyle, metabolic syndrome (MS) and hormones. Read More

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http://dx.doi.org/10.4081/ejtm.2019.8776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254422PMC

Author Correction: LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.

Nat Commun 2020 Jun 4;11(1):2895. Epub 2020 Jun 4.

Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41467-020-16615-9DOI Listing

Prognosis of prostate cancer and bone metastasis pattern of patients: a SEER-based study and a local hospital based study from China.

Sci Rep 2020 Jun 4;10(1):9104. Epub 2020 Jun 4.

Department of Orthopedics Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Prostate cancer (PCa) is the leading cause of cancer-related death among men worldwide. Knowledge of the prognostic factors of PCa and the bone metastasis pattern of patients would be helpful for patients and doctors. The data of 177,255 patients with prostate cancer diagnosed between 2010 and 2013 with at least five years of follow-up were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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http://dx.doi.org/10.1038/s41598-020-64073-6DOI Listing

Thiol Groups as a Biomarker for the Diagnosis and Prognosis of Prostate Cancer.

Sci Rep 2020 Jun 4;10(1):9093. Epub 2020 Jun 4.

Department of Pathology, Clinical Analysis and Toxicology, Laboratory of Research in Applied Immunology, University of Londrina, Londrina, Paraná, Brazil.

Oxidative stress (OS) is associated with the onset of prostate cancer (PCa). The aims of this study are to examine whether OS biomarkers may be employed as external validating criteria for the diagnosis PCa. This case-control study recruited 204 subjects, 73 patients with PCa, 67 patients with benign prostate hyperplasia (BPH), and 64 healthy controls (HC) and assayed plasma prostate-specific antigen (PSA), protein thiol (-SH) groups, lipid hydroperoxides, carbonyl proteins (PCB), advanced oxidation protein products (AOPP), and total radical-trapping antioxidant parameter (TRAP). Read More

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http://dx.doi.org/10.1038/s41598-020-65918-wDOI Listing

Comparative Effectiveness of Radiotherapy versus Focal Laser Ablation in Patients with Low and Intermediate Risk Localized Prostate Cancer.

Sci Rep 2020 Jun 4;10(1):9112. Epub 2020 Jun 4.

Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical big data, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

At present, focal laser ablation (FLA) as a new PCa local treatment has attracted attention. We aim at comparing the survival outcomes between radiotherapy (RT) and FLA to reveal whether FLA can be used as an alternative to RT for patients with low and intermediate-risk localized PCa.We conducted analyses with data from the SEER database (2004-2015). Read More

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http://dx.doi.org/10.1038/s41598-020-65863-8DOI Listing

A Conversation Between Howard Soule and Johannes Czernin.

J Nucl Med 2020 Jun;61(6):774-776

David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://dx.doi.org/10.2967/jnumed.120.247031DOI Listing

Porous graphene based electrochemical immunosensor using Cu(BTC) metal-organic framework as nonenzymatic label.

Talanta 2020 Sep 14;217:121042. Epub 2020 Apr 14.

School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, 510006, PR China.

An electrochemical immunosensor for highly sensitive detection of cancer biomarkers has been developed based on the combination of a sensing platform of polydopamine modified porous graphene and a nonenzymatic label of metal-organic framework (MOF) conjugated secondary antibody. This approach achieves a wide range of linear response from 0.1 to 10 ng/mL, low detection limit of 0. Read More

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http://dx.doi.org/10.1016/j.talanta.2020.121042DOI Listing
September 2020

Incidence and mortality of cancer in the Volta Region of Ghana.

Exp Biol Med (Maywood) 2020 Jun 4:1535370220931514. Epub 2020 Jun 4.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Accra, Ghana.

Impact Statement: Region-specific cancer reports are essential in knowing the common cancers in specific populations. This study reports all cancer types recorded in the major hospitals in the Volta Region of Ghana, a population that is sparsely captured in the national cancer registries. The study identified the common cancers as well as the death rates in the Volta Region, hence contributing to the national effort to report cancer data. Read More

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http://dx.doi.org/10.1177/1535370220931514DOI Listing

Anti-PSMA CAR-engineered NK-92 Cells: An Off-the-shelf Cell Therapy for Prostate Cancer.

Cells 2020 Jun 2;9(6). Epub 2020 Jun 2.

Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.

Prostate cancer (PCa) has become the most common cancer among males in Europe and the USA. Adoptive immunotherapy appears a promising strategy to control the advanced stages of the disease by specifically targeting the tumor, in particular through chimeric antigen receptor T (CAR-T) cell therapy. Despite the advancements of CAR-T technology in the treatment of hematological malignancies, solid tumors still represent a challenge. Read More

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http://dx.doi.org/10.3390/cells9061382DOI Listing

Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer.

J Clin Med 2020 Jun 2;9(6). Epub 2020 Jun 2.

Maimonides Institute for Biomedical Research of Córdoba (IMIBIC), 14004 Cordoba, Spain.

Certain components of the somatostatin-system play relevant roles in Prostate Cancer (PCa), whose most aggressive phenotype (Castration-Resistant-PCa (CRPC)) remains lethal nowadays. However, neuronostatin and the G protein-coupled receptor 107 (GPR107), two novel members of the somatostatin-system, have not been explored yet in PCa. Consequently, we investigated the pathophysiological role of NST/GPR107-system in PCa. Read More

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http://dx.doi.org/10.3390/jcm9061703DOI Listing

A Scoping Review of Interactions between Omega-3 Long-Chain Polyunsaturated Fatty Acids and Genetic Variation in Relation to Cancer Risk.

Nutrients 2020 Jun 2;12(6). Epub 2020 Jun 2.

Teo Research Consulting, Silver Spring, MD 20910, USA.

This scoping review examines the interaction of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and genetic variants of various types of cancers. A comprehensive search was performed to identify controlled and observational studies conducted through August 2017. Eighteen unique studies were included: breast cancer (n = 2), gastric cancer (n = 1), exocrine pancreatic cancer (n = 1), chronic lymphocytic leukemia (n = 1), prostate cancer (n = 7) and colorectal cancer (n = 6). Read More

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http://dx.doi.org/10.3390/nu12061647DOI Listing

An experimental and algorithm-based study of the spectral features of breast cancer patients by a photodiagnosis approach.

Photodiagnosis Photodyn Ther 2020 Jun 1:101851. Epub 2020 Jun 1.

Department of Electrical Computer Engineering, COMSATS University Islambad, Islamabad Campus, Park Road, Chak Shahzad, Islamabad, 45550, Pakistan.

In the present study, the spectral diagnosis of blood plasma samples of breast cancer patients and an equal number of normal controls was investigated. A set of ratio parameters was acquired by employing SXS and FES. The samples were also analyzed statistically by employing Welch two-sample t-tests, and the effects of three ratio parameters, R, R, and R, were also studied by plotting them against the subject numbers. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101851DOI Listing

A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex.

Biochimie 2020 Jun 1. Epub 2020 Jun 1.

Department of Clinical Biochemistry, Faculty of Medicine, Istinye University, Istanbul, Turkey. Electronic address:

Autophagy is a catabolic process for cells that can provide energy sources and allows cancer cells to evade cell death. Therefore, studies on the combination of autophagy inhibitors with drugs are increasing as a new treatment modality in cancer. Previously, we reported the anti-tumor activity of a Palladium (Pd)(II) complex against different types of cancer in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.biochi.2020.05.010DOI Listing

Urethral luminal epithelia are castration-insensitive cells of the proximal prostate.

Prostate 2020 Jun 4. Epub 2020 Jun 4.

Department of Urology, UT Southwestern Medical Center, Dallas, Texas.

Background: Castration-insensitive epithelial progenitors capable of regenerating the prostate have been proposed to be concentrated in the proximal region based on facultative assays. Functional characterization of prostate epithelial populations isolated with individual cell surface markers has failed to provide a consensus on the anatomical and transcriptional identity of proximal prostate progenitors.

Methods: Here, we use single-cell RNA sequencing to obtain a complete transcriptomic profile of all epithelial cells in the mouse prostate and urethra to objectively identify cellular subtypes. Read More

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http://dx.doi.org/10.1002/pros.24020DOI Listing

Obesity, race, and long-term prostate cancer outcomes.

Cancer 2020 Jun 4. Epub 2020 Jun 4.

Urology Section, Department of Surgery, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.

Background: The authors previously found that obesity was linked with prostate cancer (PC)-specific mortality (PCSM) among men who underwent radical prostatectomy (RP). Herein, in a larger RP cohort, the authors investigated whether the association between obesity and long-term PC outcomes, including PCSM, differed by race.

Methods: Data from 5929 patients who underwent RP and were in the Shared Equal Access Regional Cancer Hospital (SEARCH) database were analyzed. Read More

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http://dx.doi.org/10.1002/cncr.32906DOI Listing

Financial conflicts of interest among National Comprehensive Cancer Network clinical practice guideline panelists in 2019.

Cancer 2020 Jun 4. Epub 2020 Jun 4.

Department of Internal Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.

Background: Clinical practice guidelines (CPGs) are evidence-based guidelines that serve as a standard of care in oncology practice, reimbursements, and quality improvement initiatives. To our knowledge, the extent of financial conflicts of interest (FCOIs) in National Comprehensive Cancer Network (NCCN) guidelines have not been systemically evaluated. The current study evaluated the extent of FCOIs in the NCCN CPGs for the most common malignancies in the United States. Read More

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http://dx.doi.org/10.1002/cncr.32997DOI Listing

Comparison of perioperative outcomes in elderly (age ≧ 75 years) vs. younger men undergoing robot-assisted radical prostatectomy.

PLoS One 2020 4;15(6):e0234113. Epub 2020 Jun 4.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Objectives: To investigate perioperative, oncologic, and functional outcomes of robot-assisted radical prostatectomy (RARP) in men of age ≥ 75 years in comparison with younger men.

Methods: From November 2011 to December 2018, six hundred and thirty patients with prostate cancer underwent robot-assisted radical prostatectomy (RARP). A total of 614 patients were analyzed after excluding 16 patients who were treated with hormone therapy prior to RARP. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234113PLOS

Detection of extracellular vesicles in plasma and urine of prostate cancer patients by flow cytometry and surface plasmon resonance imaging.

PLoS One 2020 4;15(6):e0233443. Epub 2020 Jun 4.

Laboratory of Experimental Clinical Chemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Large (> 1 μm) tumor-derived extracellular vesicles (tdEVs) enriched from the cell fraction of centrifuged whole blood are prognostic in metastatic castration-resistant prostate cancer (mCRPC) patients. However, the highest concentration of tdEVs is expected in the cell-free plasma fraction. In this pilot study, we determine whether mCRPC patients can be discriminated from healthy controls based on detection of tdEVs (< 1μm, EpCAM+) and/or other EVs, in cell-free plasma and/or urine. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233443PLOS

[What the last 10 years have brought in the treatment of benign prostatic hyperplasia].

Rev Med Liege 2020 May;75(5-6):440-444

Service d'Urologie, CHU Liège, Belgique.

Benign prostatic hyperplasia (BPH) is a very frequent condition, most of the times related to age, and with initial manifestations and long term development that may vary widely. Treatment is necessary only if the patient is symptomatic or if he has complications related to the BPH. During the last 10 years, the various BPH treatment means have evolved significantly. Read More

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Stereotactic Body Radiation Therapy for Intermediate-risk Prostate Cancer With VMAT and Real-time Electromagnetic Tracking: A Phase II Study.

Am J Clin Oncol 2020 Jun 2. Epub 2020 Jun 2.

Departments of Radiotherapy and Radiosurgery.

Objectives: Stereotactic body radiation treatment represents an intriguing therapeutic option for patients with early-stage prostate cancer. In this phase II study, stereotactic body radiation treatment was delivered by volumetric modulated arc therapy with flattening filter free beams and was gated using real-time electromagnetic transponder system to maximize precision of radiotherapy and, potentially, to reduce toxicities.

Materials And Methods: Patients affected by histologically proven prostate adenocarcinoma and National Comprehensive Cancer Network (NCCN) intermediate class of risk were enrolled in this phase II study. Read More

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http://dx.doi.org/10.1097/COC.0000000000000721DOI Listing

In Vivo Quantification of Water Diffusion, Stiffness, and Tissue Fluidity in Benign Prostatic Hyperplasia and Prostate Cancer.

Invest Radiol 2020 Jun 2. Epub 2020 Jun 2.

From the Departments of Radiology.

Objectives: Water diffusion, tissue stiffness, and viscosity characterize the biophysical behavior of tumors. However, little is known about how these parameters correlate in prostate cancer (PCa). Therefore, we paired tomoelastography of the prostate with diffusion-sensitive magnetic resonance imaging for the quantitative mapping of biophysical parameters in benign prostatic hyperplasia (BPH) and PCa. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000685DOI Listing

The presence of intraductal carcinoma of the prostate is closely associated with poor prognosis: a systematic review and meta-analysis.

Asian J Androl 2020 Jun 2. Epub 2020 Jun 2.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

We aimed to confirm the predictive ability of the presence of intraductal carcinoma of the prostate (IDC-P) for prognosis and the associations between IDC-P and clinicopathological parameters. Studies were identified in PubMed, Cochrane Library, EMBASE, Web of Science, and SCOPUS up to December 1, 2019. Hazard ratios (HRs) for survival data and odds ratios for clinicopathological data with 95% confidence intervals (CIs) were extracted. Read More

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http://dx.doi.org/10.4103/aja.aja_21_20DOI Listing

Does the Visibility of Grade Group 1 Prostate Cancer on Baseline Multiparametric Magnetic Resonance Imaging Impact Clinical Outcomes?

J Urol 2020 Jun 4:101097JU0000000000001157. Epub 2020 Jun 4.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Purpose: To assess whether the visibility of grade group (GG)1 prostate cancer (PCa) on baseline multiparametric magnetic resonance imaging (mpMRI) affects clinical outcomes.

Materials And Methods: We evaluated 454 men who underwent mpMRI between 2006 and 2018 with maximum GG1 PCa inclusive of MRI-targeted biopsy. MpMRIs were graded as negative, equivocal, or positive. Read More

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http://dx.doi.org/10.1097/JU.0000000000001157DOI Listing

Extensive colonic pneumatosis. Conservative or Surgical approach?

Rev Esp Enferm Dig 2020 Jun 4. Epub 2020 Jun 4.

Cirugía General y del Aparato Digestivo, Hospital Clínico Universitario de Valencia, España.

Intestinal pneumatosis is a radiologic finding that consists of the presence of air in the intestinal wall. The etiology is extensive and can range from a benign entity to one that compromises the patients´ life. It is important to know and recognize the differences between them as the surgical management will depend on it. Read More

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http://dx.doi.org/10.17235/reed.2020.6825/2019DOI Listing

Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.

Eur Rev Med Pharmacol Sci 2020 May;24(10):5303-5309

Department of Urology Surgery, Yinzhou People's Hospital, Yinzhou, China.

Objective: The importance of circular RNAs in malignant tumors causes more attention in researchers. Circular RNA_LARP4 is identified as a tumor suppressor in gastric cancer, but the role of circular RNA_LARP4 in prostate cancer (PCa) remains unclear. Our work aims to uncover whether and how circular RNA_LARP4 functions in the PCa development. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21312DOI Listing

Isolation and analysis of a non-protein low molecular weight thiol-mercurial adduct from human prostate lymph node cells (LNCaP).

Authors:
Michael Gronow

Biosci Rep 2020 Jun 4. Epub 2020 Jun 4.

Cambridge Cancer Research Fund, Cambridge, United Kingdom.

Thiol compounds present in human malignant prostate cells (LNCaP) were investigated after reaction with a mercurial blocking reagent. After extracting the cellular glutathione and some other low molecular weight thiols using trichloroacetic acid the resulting the protein precipitate was extracted with buffered 8M urea containing 2-chloromercuri-4-nitrophenol in an equimolar amount to that of the thiol present. After removing the insoluble chromatin fraction the urea soluble labelled adducts formed were chromatographed on G15 Sephadex. Read More

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http://dx.doi.org/10.1042/BSR20201343DOI Listing

Self-perceived burden and its associations with health-related quality of life among urologic cancer patients.

Eur J Cancer Care (Engl) 2020 Jun 3:e13248. Epub 2020 Jun 3.

Centre for Epidemiology and Evidence-Based Practice, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Objective: This study examined the prevalence of self-perceived burden (SPB) and its association with health-related quality of life (HRQoL) among urologic cancer patients.

Methods: This was a prospective, cross-sectional study. A total of 429 respondents diagnosed with urologic cancers (prostate, bladder and renal cancer) from Sarawak General Hospital and Subang Jaya Medical Centre in Malaysia were interviewed by using a structured questionnaire. Read More

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http://dx.doi.org/10.1111/ecc.13248DOI Listing

Radical prostatectomy versus deferred treatment for localised prostate cancer.

Cochrane Database Syst Rev 2020 Jun 4;6:CD006590. Epub 2020 Jun 4.

Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, Netherlands.

Background: Prostate cancer is a common cancer but is oftentimes slow growing. When confined to the prostate, radical prostatectomy (RP), which involves removal of the prostate, offers potential cure that may come at the price of adverse events. Deferred treatment, involving observation and palliative treatment only (watchful waiting (WW)) or close monitoring and delayed local treatment with curative intent as needed in the setting of disease progression (active monitoring (AM)/surveillance (AS)) might be an alternative. Read More

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http://dx.doi.org/10.1002/14651858.CD006590.pub3DOI Listing