111,954 results match your criteria Prostaglandins Leukotrienes & Essential Fatty Acids [Journal]


Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP receptor antagonist.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Various studies have confirmed that prostaglandins (PG) alter the bladder motor activity and micturition reflex in both human and animals. However, no sufficient data is reported about the effect of cyclooxygenase (COX) inhibitors neither in normal bladder physiology nor in pathological conditions. This study aims to compare the potential effects of some COX inhibitors with varying COX-1/COX-2 selectivities (indomethacin, ketoprofen, and diclofenac) with that of the selective COX-2 inhibitor (DFU) on bladder function. Read More

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December 2018

Inhibition of ASM activity ameliorates DSS-induced colitis in mice.

Prostaglandins Other Lipid Mediat 2018 Dec 11. Epub 2018 Dec 11.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address:

Acid sphingomyelinase (ASM) is a membrane lipid hydrolase, acting to generate ceramide and regulate cell functions and inflammatory responses.The roles of ASM in mediating T cell functions are postulated whereas its function in regulation of macrophages remains uncertain. The study was performed to explore ASM activity in control of macrophage functions. Read More

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December 2018
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Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis.

J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathology, University of Michigan, Ann Arbor, Michigan; and

Background: Renal interstitial fibrosis results from activation and proliferation of fibroblasts to myofibroblasts, secretion and accumulation of extracellular matrix, and displacement of normal renal tubules. In contrast to chronic renal disease, acute injury may be repaired, a process that includes a decrease in the number of myofibroblasts in the interstitium and degradation of the accumulated extracellular matrix, leaving little evidence of prior injury.

Methods: To investigate whether activated fibroblasts demonstrate changes in gene expression that correspond with regression after acute injury but are not observed in chronic models of fibrosis, we used microarrays to analyze gene expression patterns among fibroblast populations at different stages of injury or repair. Read More

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December 2018

Treatment of actinic keratosis through inhibition of cyclooxygenase-2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5.

Dermatol Ther 2018 Dec 6:e12800. Epub 2018 Dec 6.

DISSAL Section of Dermatology, University of Genoa-IRCCS, AOU San Martino-IST, Genoa, Italy.

Cyclooxygenase-2 (COX-2) and its metabolic product prostaglandin E (PGE ) are induced in response to growth factors, inflammatory cytokines, tumour promoters, activated oncogenes and, in the skin, ultraviolet (UV) radiation. Accumulating evidence suggests a role for the COX-2/PGE pathway in tumourigenesis in various tissue types including cutaneous squamous cell carcinoma. There is also strong evidence for a role in the development of actinic keratoses (AKs) - common dysplastic lesions of the skin associated with UV radiation overexposure - considered as part of a continuum with skin cancer. Read More

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December 2018

Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study.

Clin Ophthalmol 2018 26;12:2399-2407. Epub 2018 Nov 26.

Department of Ophtalmology, Claude Huriez Hospital, University Hospital, Lille, France.

Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops.

Aim: To assess the efficacy and local tolerance after 12 months and patient satisfaction regarding local treatment tolerance and handling at inclusion and after 6 months of PF latanoprost compared to preserved glaucoma eye drops.

Methods: This was an international, prospective, and observational real-life study. Read More

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November 2018

Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome.

J Mol Med (Berl) 2018 Dec 7. Epub 2018 Dec 7.

Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Sinusoidal obstruction syndrome (SOS) is a major complication after hematopoietic stem cell transplantation and belongs to a group of diseases increasingly identified as transplant-related systemic endothelial disease. Administration of defibrotide affords some protection against SOS, but the effect is modest. Hence, there is unmet medical need justifying the preclinical search for alternative approaches. Read More

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December 2018

Effect of GnRH or hCG administration on Day 4 post insemination on reproductive performance in Merino sheep of North Patagonia.

Theriogenology 2018 Dec 3;126:63-67. Epub 2018 Dec 3.

Laboratorio de Reproducción de Rumiantes Menores, INTA Bariloche, San Carlos de Bariloche, Argentina.

Different therapeutic strategies have been used with the objective of improve luteal function to reduce embryonic losses. The objective of this work was to study the effect of the administration of GnRH or hCG at Day 4 post fixed time artificial insemination (FTAI) on reproductive efficiency in Merino sheep during the breeding season in North Patagonia. Estrus of multiparous Merino ewes (n = 288) was synchronized by two injections of prostaglandins (PG; 125 μg, Cloprostenol), 14 days apart. Read More

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December 2018
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VIP modulates the ALX/FPR2 receptor axis toward inflammation resolution in a mouse model of bacterial keratitis.

Prostaglandins Other Lipid Mediat 2018 Dec 4;140:18-25. Epub 2018 Dec 4.

Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, United States. Electronic address:

Vasoactive intestinal peptide (VIP) has been shown to regulate corneal inflammation. Formyl peptide receptor 2 (FPR2) is a transmembrane protein belonging to the GPCR family. Ligands include pro-resolving lipids, lipoxin A4 (LXA4) and resolvin D1 (RvD1). Read More

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December 2018

Changes in aqueous oxidative stress, prostaglandins, and cytokines: Comparisons of low-energy femtosecond laser-assisted cataract surgery versus conventional phacoemulsification.

J Cataract Refract Surg 2018 Dec 5. Epub 2018 Dec 5.

From the Cornea and Refractive Surgery Group (Liu, Setiawan, Ang, Yam, Mehta), Eye Research Institute, the Singapore National Eye Centre (Liu, Ang, Mehta), and the Duke-NUS Medical School (Liu, Yam, Mehta), Singapore. Electronic address:

Purpose: To compare the aqueous oxidative stress, prostaglandin E (PGE), and cytokine levels after low-energy femtosecond laser-assisted cataract surgery versus conventional phacoemulsification, and to evaluate the effect of a nonsteroidal antiinflammatory drug (NSAID) on the aqueous profiles.

Setting: Singapore National Eye Center, Singapore.

Design: Randomized controlled trial. Read More

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December 2018

An update and systematic review on the treatment of primary dysmenorrhea.

JBRA Assist Reprod 2018 Dec 6. Epub 2018 Dec 6.

Nursing Research Center, Golestan University of Medical Sciences, Gorgan, IR Iran.

Objectives: Primary dysmenorrhea is a painful uterine contraction caused by endometrial laceration. Drug therapies and complementary medicine have been used to treat dysmenorrhea. The aim of this study was to investigate and offer an updated perspective on the treatments for dysmenorrhea. Read More

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December 2018
4 Reads

Central neuroimmune activity and depressive-like behavior in response to repeated maternal separation and injection of LPS.

Physiol Behav 2018 Nov 30;199:366-374. Epub 2018 Nov 30.

Department of Psychology, Wright State University, Dayton, OH 45435, USA.

Disruption of attachment relations in early life is linked to greater vulnerability to depressive illness at later ages. Evidence suggests this process involves stress-induced activation of central inflammatory factors, though the specific mediators and processes involved are not known. We used a guinea pig model in which effects of maternal separation appear more clearly due to absence of the attachment figure than is the case for other laboratory rodents. Read More

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November 2018

Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease.

Authors:
Tanya M Laidlaw

World J Otorhinolaryngol Head Neck Surg 2018 Sep 5;4(3):162-168. Epub 2018 Sep 5.

Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, USA.

It is well-established that following ingestion of aspirin or any other inhibitor of cyclooxygenase-1, patients with Samter's disease, or aspirin-exacerbated respiratory disease (AERD) develop the sudden onset of worsening respiratory clinical symptoms, which usually involves nasal congestion, rhinorrhea, wheezing and bronchospasm. Gastrointestinal distress, nausea, a pruritic rash and angioedema can also occasionally develop. However, the underlying pathologic mechanism that drives these clinical reactions remains elusive. Read More

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September 2018
5 Reads

Resveratrol treatment inhibits acute pharyngitis in the mice model through inhibition of PGE2/COX-2 expression.

Saudi J Biol Sci 2018 Nov 9;25(7):1468-1472. Epub 2017 May 9.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

The aim of the present study was to investigate the effect of resveratrol on acute pharyngitis in the mice models induced by xylene and carrageenan treatment. The mice treated with various doses of resveratrol (5, 10, 15, 20 and 30 mg/kg) showed inhibition of edema in a dose dependent manner. The edema formation was reduced by 67% in the mice treated with 20 mg/kg of resveratrol compared to those in the control group. Read More

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November 2018
1 Read

Glaucoma medications in pregnancy.

Oman J Ophthalmol 2018 Sep-Dec;11(3):195-199

Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.

Glaucoma is a chronic, progressive disease of the optic nerve which is relatively uncommon in childbearing age; however, its management is a real challenge. Although the intraocular pressure decreases in pregnancy, many glaucoma patients continue to require treatment. In addition to the side effects, antiglaucoma medications on the mother, the possible side effects of drugs on the fetus must be taken into account. Read More

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December 2018

Clinical and experimental aspects of breathing modulation by inflammation.

Auton Neurosci 2018 Nov 11. Epub 2018 Nov 11.

Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, QRO 76230, México. Electronic address:

Neuroinflammation is produced by local or systemic alterations and mediated mainly by glia, affecting the activity of various neural circuits including those involved in breathing rhythm generation and control. Several pathological conditions, such as sudden infant death syndrome, obstructive sleep apnea and asthma exert an inflammatory influence on breathing-related circuits. Consequently breathing (both resting and ventilatory responses to physiological challenges), is affected; e. Read More

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November 2018
2 Reads

Immunosenescence of Natural Killer Cells, Inflammation, and Alzheimer's Disease.

Int J Alzheimers Dis 2018 1;2018:3128758. Epub 2018 Nov 1.

Instituto Maimónides de Investigación Biomédica (IMIBIC), Córdoba, Spain.

Alzheimer's disease (AD) represents the most common cause of dementia in the elderly. AD is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although the aetiology of AD is not clear, both environmental factors and heritable predisposition may contribute to disease occurrence. Read More

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November 2018
7 Reads

Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest.

Prostaglandins Leukot Essent Fatty Acids 2018 Nov 23. Epub 2018 Nov 23.

Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Center for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Cardiovascular and Metabolomics Research Center, Hualien Tzu Chi Hospital, Taiwan; Department of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan. Electronic address:

We previously discovered that palmitic acid methyl ester (PAME) is a potent vasodilator first identified and released from the superior cervical ganglion and remain understudied. Thus, we investigated PAME's role in modulating cerebral blood flow (CBF) and neuroprotection after 6 min of cardiac arrest (model of global cerebral ischemia). Our results suggest that PAME can enhance CBF under normal physiological conditions, while administration of PAME (0. Read More

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November 2018
5 Reads

The COX2 genetic variants in oral squamous cell carcinoma in Turkish population.

Cell Mol Biol (Noisy-le-grand) 2018 Nov 30;64(14):96-100. Epub 2018 Nov 30.

Department of Molecular Medicine, Institute of Aziz Sancar Experimental Medicine Research, Istanbul University, Istanbul, Turkey.

Oral squamous cell carcinoma (OSCC) is a common type of cancer that genetic and environmental factors also lifestyle habits, infections play important roles in the pathogenesis of disease. Cyclooxygenase 2 (COX2) is the inducible isoform of enzyme which convert arachidonic acid to prostaglandins. It was known that alterations in COX2 gene functions contribute to the inflammation process thus induce cancer progression, including cell proliferation, apoptosis, adhesion, invasion and metastasis. Read More

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November 2018
3 Reads

Ovulation: Parallels with Inflammatory Processes.

Endocr Rev 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY.

The midcycle surge of luteinizing hormone (LH) sets in motion interconnected networks of signaling cascades to bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators of these LH-induced signaling cascades are associated with inflammation, leading to the postulate that ovulation is similar to an inflammatory response. First responders to the LH surge are granulosa and theca cells, which produce steroids, prostaglandins, chemokines, and cytokines, which are also mediators of inflammatory processes. Read More

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November 2018

Redox Modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.

Toxicol Mech Methods 2018 Nov 29:1-40. Epub 2018 Nov 29.

a Department of Biophysics , Panjab University , Chandiigarh - 160014 , India.

Ulcerative colitis (UC), a form of inflammatory bowel disease (IBD), is an immune-modulated disorder characterized by chronic and recurring inflammatory episodes. Oxidative stress and COX pathway of prostaglandin (PG) biosynthesis is indispensable to pathogenesis of UC. Any imbalance between PGs can compromise the mucosal homeostasis, leading to mucosal damage and chronic inflammation. Read More

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November 2018
3 Reads
1.548 Impact Factor

To evaluate immunoreactivity of cyclooxygenase-2 in cases of endometrial carcinoma and correlate it with expression of p53 and vascular endothelial growth factor.

J Cancer Res Ther 2018 Oct-Dec;14(6):1366-1372

Department of Radiation Oncology, Army Hospital (R & R), New Delhi, India.

Context: Increased levels of prostaglandins have been detected in cancers of several anatomic sites, including those of endometrium. Several studies have shown that cyclooxygenase-2 (COX-2) expression is aberrantly increased in various human epithelial cancers, and cellular up-regulation of COX-2 may be a common mechanism in epithelial carcinogenesis.

Aims: To examine the expressions of COX-2, p53 and vascular endothelial growth factor (VEGF) in endometrial cancer and their relationships with clinicopathologic characteristics. Read More

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November 2018
4 Reads

The COX-2/prostanoid signaling cascades in seizure disorders.

Expert Opin Ther Targets 2019 Jan 2;23(1):1-13. Epub 2018 Dec 2.

a Department of Pharmacology , Emory University School of Medicine , Atlanta , GA , USA.

Introduction:A robust neuroinflammatory response is a prevalent feature of multiple neurological disorders, including epilepsy and acute status epilepticus. One component of this neuroinflammatory reaction is the induction of cyclooxygenase-2 (COX-2), synthesis of several prostaglandins and endocannabinoid metabolites, and subsequent activation of prostaglandin and related receptors. Neuroinflammation mediated by COX-2 and its downstream effectors has received considerable attention as a potential target class to ameliorate the deleterious consequences of neurological injury. Read More

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January 2019

Lysophospholipases Cooperate to Mediate Lipid Homeostasis and Lysophospholipid Signaling.

J Lipid Res 2018 Nov 27. Epub 2018 Nov 27.

Vanderbilt University, United States

Lysophospholipids (LysoPL) are bioactive lipid species involved in cellular signaling processes and the regulation of cell membrane structure. LysoPLs are metabolized through the action of lysophospholipases, including lysophospholipase A1 (LYPLA1) and lysophospholipase A2 (LYPLA2). A new X-ray crystal structure of LYPLA2 compared to a previously published structure of LYPLA1 demonstrated near identical folding of the two enzymes; however, LYPLA1 and LYPLA2 have displayed distinct substrate specificities in recombinant enzyme assays. Read More

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November 2018
2 Reads

Determination of potential childhood asthma biomarkers using a powerful methodology based on microextraction by packed sorbent combined with ultra-high pressure liquid chromatography. Eicosanoids as case study.

J Chromatogr A 2018 Nov 22. Epub 2018 Nov 22.

CQM - Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9020-105 Funchal, Portugal; Faculdade de Ciências Exatas e da Engenharia, Universidade da Madeira, Campus Universitário da Penteada, 9020-105, Funchal, Portugal. Electronic address:

Leukotrienes and prostaglandins are arachidonic acid bioactive derived eicosanoids and key mediators of bronchial inflammation and response modulation in the airways contributing to the pathophysiology of asthma. An easy-to-use ultra-high pressure liquid chromatography (UHPLC)-based strategy was developed to characterize biomarkers of lipid peroxidation: leukotrienes E (LTE) and B (LTB) and 11β-prostaglandin F (11βPGF), present in urine of asthmatic patients (N = 27) and healthy individuals (N = 17). A semi-automatic eVol®-microextraction by packed sorbent (MEPS) was used to isolate the target analytes. Read More

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November 2018

Association between blood polyunsaturated fatty acid levels and depressive symptoms in breast cancer survivors.

Prostaglandins Leukot Essent Fatty Acids 2018 Dec 2;139:9-13. Epub 2018 Nov 2.

Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan. Electronic address:

In contrast to the cumulative evidence suggesting the inverse association of n-3 polyunsaturated fatty acids (PUFAs) with depression, few studies have examined the association of n-6 PUFAs with depression. In particular, no study has examined the relationship between n-6 PUFAs and depression in cancer patients. Thus, we conducted this cross-sectional study to comprehensively examine the association of n-3 and n-6 PUFAs with depressive symptoms in breast cancer survivors. Read More

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December 2018
1 Read

Antiemetic doses of dexamethasone and their effects on immune cell populations and plasma mediators of inflammation resolution in healthy volunteers.

Prostaglandins Leukot Essent Fatty Acids 2018 Dec 8;139:31-39. Epub 2018 Nov 8.

Medical School, Royal Perth Hospital Unit, University of Western Australia, Box X2214 GPO Perth, Western Australia 6847, Australia; Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Australia.

Introduction: The synthetic glucocorticoid dexamethasone is a commonly administered antiemetic. It has immunosuppressive effects and may alter postoperative blood glucose concentrations. Dexamethasone can effect key enzymes involved in inflammation resolution that is an active process driven by specialised lipid mediators of inflammation resolution (SPM). Read More

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December 2018
1 Read

Comparison of breast milk fatty acid composition from mothers of premature infants of three countries using novel dried milk spot technology.

Prostaglandins Leukot Essent Fatty Acids 2018 Dec 31;139:3-8. Epub 2018 Aug 31.

School of Agriculture, Food & Wine, University of Adelaide, Waite Campus, Urrbrae, SA 5064, Australia; Healthy Mothers, Babies and Children theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA 5000, Australia. Electronic address:

Long chain polyunsaturated fatty acid (LCPUFA) intake during infancy has been associated with many health benefits, and the LCPUFA intake of breastfed infants is largely dependent on the composition of breast milk. The conventional method for breast milk fatty acid profiling is complicated by the need for cold-chain transportation and storage, and the newly developed dried milk spot (DMS) technology overcomes these difficulties. This study aimed to determine the accuracy, sensitivity and applicability of the DMS method developed based on the PUFAcoat™ technology. Read More

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December 2018
9 Reads

Docosahexaenoic acid levels in erythrocytes and their association with the University Selection Test Outcomes in Chile.

Prostaglandins Leukot Essent Fatty Acids 2018 Dec 9;139:25-30. Epub 2018 Nov 9.

Laboraroty of Nutrition and Neurological Sciences, Human Nutrition Area, Institute of Nutrition and Food Technology Dr. Fernando Monckeberg Barros (INTA), University of Chile, Santiago, Chile. Electronic address:

The aim of this study was to quantitate the relative impact of DHA and AA levels in erythrocytes, anthropometric parameters and socio-economic status of school-age children, of both genders, graduated from high school in Chile, on the scholastic achievement in the University Selection Test (Prueba de Selección Universitaria, PSU) both language scholastic achievement (LSA) and mathematics scholastic achievement (MSA). A representative sample of 671 school-age young graduated from high school in 2013, 550 and 548 of them took the PSU for LSA and MSA, respectively. Only school-age young with high (n = 91) and low (n = 69) SA in both tests were considered. Read More

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December 2018
6 Reads

Low omega-3 index and polyunsaturated fatty acid status in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Prostaglandins Leukot Essent Fatty Acids 2018 Dec 9;139:20-24. Epub 2018 Nov 9.

Department of Preventive Cardiology, Medizinische Klinik I, Ludwig Maximilians-University, Munich, Germany; Omegametrix, Martinsried, Germany.

Background: Several studies have suggested that low levels of omega-3 fatty acids (n-3 PUFAs) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with cardiovascular risk, major depression, sleep problems, inflammation and other health-related issues. So far, however, erythrocyte PUFA status in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) has not been established. This study aimed to determine whether n-3 PUFA content and omega-3 index are associated with measures in CFS/ME patients. Read More

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December 2018

Higher baseline expression of the PTGS2 gene and greater decreases in total colonic fatty acid content predict greater decreases in colonic prostaglandin-E concentrations after dietary supplementation with ω-3 fatty acids.

Prostaglandins Leukot Essent Fatty Acids 2018 Dec 2;139:14-19. Epub 2018 Nov 2.

Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI; Department of Family Medicine, University of Michigan, Ann Arbor, MI. Electronic address:

This study evaluated whether mRNA expression of major genes regulating formation of prostaglandin (PG)E in the colon and colonic fatty acid concentrations are associated with the reduction in colonic mucosal PGE after dietary supplementation with omega-3 (ω-3) fatty acids. Supplementation with ω-3 fatty acids was done for 12 weeks using personalized dosing that was expected to reduce colonic PGE by 50%. In stepwise linear regression models, the ω-3 fatty acid dose and baseline BMI explained 16. Read More

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December 2018

Omega-6 fatty acids, inflammation and cardiometabolic health: Overview of supplementary issue.

Prostaglandins Leukot Essent Fatty Acids 2018 Dec 20;139:1-2. Epub 2018 Oct 20.

Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, and OmegaQuant, LLC, Sioux Falls, SD, USA.

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December 2018

Molecular and mechanical factors contributing to ductus arteriosus patency and closure.

Congenit Heart Dis 2018 Nov 23. Epub 2018 Nov 23.

Mildred T. Stahlman Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.

Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left-to-right shunt through the patent ductus arteriosus, a condition associated with significant morbidities. Numerous factors contribute to the shift from fetal ductus patency to postnatal closure, requiring precise coordination of molecular cues with biomechanical forces and underlying genetic influences. Read More

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November 2018

Redox regulation and NO/cGMP plus K channel activation contributes to cardiorenal protection induced by Cuphea carthagenensis (Jacq.) J.F. Macbr. in ovariectomized hypertensive rats.

Phytomedicine 2018 Dec 19;51:7-19. Epub 2018 May 19.

Laboratório de Eletrofisiologia e Farmacologia Cardiovascular, Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Rodovia Dourados-Itahum, km 12, P.O. Box 533, 79.804-970, Dourados, MS, Brazil. Electronic address:

Background: One of the medicinal plants widely used by the population in the treatment of hypertension, atherosclerosis and circulatory disorders is Cuphea carthagenensis (Jacq.) J.F. Read More

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December 2018
9 Reads

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation.

Nutrients 2018 Nov 20;10(11). Epub 2018 Nov 20.

Department of Pharmacy, University of Naples Federico II. Via Montesano 49, 80149 Naples, Italy.

Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. Even months after the end of chemotherapy, many cancer patients complain of hair loss, a condition that is psychologically difficult to manage. CIA disturbs social and sexual interactions and causes anxiety and depression. Read More

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November 2018
3 Reads

Anakinra Therapy for Non-cancer Inflammatory Diseases.

Front Pharmacol 2018 6;9:1157. Epub 2018 Nov 6.

Department of Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory mediators, including prostaglandins, cytokines, and chemokines. IL-1α is constitutively present in endothelial and epithelial cells, whereas IL-1β is inducible in myeloid cells and released following cleavage by caspase-1. Over the past 30 years, IL-1-mediated inflammation has been established in a broad spectrum of diseases, ranging from rare autoinflammatory diseases to common conditions such as gout and rheumatoid arthritis (RA), type 2 diabetes, atherosclerosis, and acute myocardial infarction. Read More

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November 2018
8 Reads

Endometrial transcripts of proinflammatory cytokine and enzymes in prostaglandin synthesis are upregulated in the bitches with atrophic pyometra.

Vet Immunol Immunopathol 2018 Nov 25;205:65-71. Epub 2018 Oct 25.

Animal Reproduction Division, ICAR - Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243 122, India.

Inflammatory markers of endometrial origin are valuable in order to differentiate the pyometra from cystic endometrial hyperplasia in the bitch. In the present study, we hypothesized that histological categorization would distinguish the differential regulation of the proinflammatory genes in the endometrium of bitches with pyometra. Ovariohysterectomy was done on bitches with confirmatory diagnosis of pyometra (n = 18). Read More

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November 2018

Cutaneous active vasodilation as a heat loss thermoeffector.

Handb Clin Neurol 2018 ;156:193-209

Department of Human Physiology, University of Oregon, Eugene, OR, United States. Electronic address:

Human skin is the interface between the human body and the environment. As such, human temperature regulation relies largely on cutaneous vasomotor and sudomotor adjustments to appropriately thermoregulate. In particular, changes in skin blood flow can increase or decrease the convective heat transfer from internal tissues to the periphery where it can increase or prevent heat loss to the environment. Read More

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January 2018

Molecular basis of central thermosensation.

Authors:
Bruno Conti

Handb Clin Neurol 2018 ;156:129-133

Departments of Molecular Medicine and of Neuroscience, Dorris Neuroscience Center, Scripps Research Institute, La Jolla, CA, United States. Electronic address:

Classic lesion and physiology experiments identified the hypothalamic preoptic area as a pivotal region in the regulation of temperature homeostasis. The preoptic area can sense changes in local temperature, receives information about ambient temperature, contributes to fever, and can affect thermoregulation in response to several biologic signals. Electrophysiologic studies indicate that these actions are mediated by a neuronal circuitry that comprises temperature-sensitive as well as temperature-insensitive neurons. Read More

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January 2018

Detoxification and activating blood circulation decoction reduces restenosis involving the TLR4/NF-κB pathway after balloon injury.

Prostaglandins Other Lipid Mediat 2018 Nov 16;140:1-8. Epub 2018 Nov 16.

College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Hunan, 410208, China. Electronic address:

Restenosis is a major problem after percutaneous coronary intervention (PCI) treatment. Inflammation is one of the major core mechanisms involved in the occurrence of restenosis, and plays an important role in intimal hyperplasia. Detoxification and activating blood circulation decoction (DABCD) is a traditional Chinese medicine that is used in the treatment and prevention of atherosclerotic and inflammatory diseases. Read More

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November 2018
3 Reads

Prostaglandin E decrease in induced sputum of hypersensitive asthmatics during oral challenge with aspirin.

Allergy 2018 Nov 17. Epub 2018 Nov 17.

Department of Internal Medicine, Jagiellonian University School of Medicine, Cracow, Poland.

Background: A special regulatory role for prostaglandin E (PGE ) has been postulated in nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD).

Objective: To investigate the effect of systemic aspirin (acetylsalicylic acid) administration on airway PGE biosynthesis in induced sputum supernatant (ISS) among subjects with NERD or aspirin-tolerant asthma with chronic rhinosinusitis with nasal polyposis (ATA-CRSwNP), as well as healthy controls (HC).

Methods: Induced sputum (IS) was collected from patients with NERD (n = 26), ATA-CRSwNP (n = 17), and HC (n = 21) at baseline and after aspirin challenge. Read More

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November 2018
6 Reads

Alpha-tocopherol potentiates the cervical resistance decreasing effects of COX-inhibitors in pregnant rats: the putative role of cyclooxygenase-2 inhibition.

J Pharmacol Exp Ther 2018 Nov 15. Epub 2018 Nov 15.

University of Szeged, Hungary

Vitamin E and their analogues as antioxidant and lipid soluble compounds can have diverse effects on the physiological processes. By binding to receptors and enzymes, they may modify the action of drugs. It has been proved that alpha-tocopherol succinate modifies the effects of β2 agonist terbutaline and cyclooxygenase (COX) inhibitors on rat trachea and myometrium. Read More

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November 2018
3 Reads

FTY720P inhibits the Na/K ATPase in Caco-2 cells via S1PR2: PGE2 and NO are along the signaling pathway.

Life Sci 2018 Dec 12;215:198-206. Epub 2018 Nov 12.

Department of Biology, Faculty of Arts & Sciences, American University of Beirut, Beirut, Lebanon. Electronic address:

Aims: Sphingosine-1-phosphate (S1P) has been implicated lately in inflammatory bowel disease which has diarrhea as one of its symptoms. Diarrhea is due to altered water movements as a result of altered electrolyte transport, and in particular sodium. Sodium movements are geared by the sodium gradient established by the Na/K ATPase. Read More

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December 2018
5 Reads

Prostacyclin: A major prostaglandin in the regulation of adipose tissue development.

J Cell Physiol 2018 Nov 15. Epub 2018 Nov 15.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

Prostaglandins (PGs) belong to the group lipid mediators and can act as local hormones. They contain 20 carbon atoms, including a 5-carbon ring, and are biosynthesized from membrane phospholipid derived arachidonic acid through the arachidonate cyclooxygenase (COX) pathway with the help of various terminal synthase enzymes. Prostacyclin (prostaglandin I ) is one of the major prostanoids produced with the help of prostacyclin synthase (prostaglandin I synthase) enzyme and rapidly hydrolyzed into 6-keto-PGF in biological fluids. Read More

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November 2018
8 Reads

PGE2 Augments Inflammasome Activation and M1 Polarization in Macrophages Infected With Typhimurium and .

Front Microbiol 2018 31;9:2447. Epub 2018 Oct 31.

Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL, United States.

Eicosanoids are cellular metabolites, which shape the immune response, including inflammatory processes in macrophages. The effects of these lipid mediators on inflammation and bacterial pathogenesis are not clearly understood. Certain eicosanoids are suspected to act as molecular sensors for the recruitment of neutrophils, while others regulate bacterial uptake. Read More

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October 2018
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Halogenated Compounds from Corals: Chemical Diversity and Biological Activities.

Mini Rev Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Department of Pharmaceutics, Qingdao University of Science and Technology, Qingdao 266042. China.

As important marine biological resources, corals produce a large amount of active organic compounds in their secondary metabolic processes, including numerous brominated, chlorinated, and iodinated compounds. These compounds, with novel structures and unique activities, guide the discovery and research of important lead compounds and novel biological mechanisms. Through large numbers of literature survey, this paper summarized a total of 145 halogenated secondary metabolites which were roughly divided into four major classes of terpenes, prostaglandins, steroids and alkaloids. Read More

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November 2018
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Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy.

Front Immunol 2018 29;9:2455. Epub 2018 Oct 29.

Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, United States.

In 2009, the H1N1 swine flu pandemic highlighted the vulnerability of pregnant women to influenza viral infection. Pregnant women infected with influenza A virus were at increased risk of hospitalization and severe acute respiratory distress syndrome (ARDS), which is associated with high mortality, while their newborns had an increased risk of pre-term birth or low birth weight. Pregnant women have a unique immunological profile modulated by the sex hormones required to maintain pregnancy, namely progesterone and estrogens. Read More

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October 2018
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Experimental evidence for re-secretion of PGE across rat alveolar epithelium by OATP2A1/-mediated transcellular transport.

J Pharmacol Exp Ther 2018 Nov 12. Epub 2018 Nov 12.

Kanazawa University.

Prostaglandin transporter Oatp2a1/ is expressed at the apical (AP) membranes of type-1 alveolar epithelial (AT1) cells. To investigate the role of OATP2A1 in PGE handling by alveolar epithelium, we studied PGE transport across and secretion from monolayers of rat AT1-like (AT1-L) cells obtained by trans-differentiation of type-2 alveolar epithelial cells (AT2) isolated from male Wistar rats. Rat AT1-L cells expressed Oatp2a1/, together with smaller amounts of Mrp4/ and Oct1/ PGE uptake was saturable with Km 43. Read More

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November 2018
2 Reads
3.972 Impact Factor

BML-111, a lipoxin receptor agonist, protects against acute injury via regulating the renin angiotensin-aldosterone system.

Prostaglandins Other Lipid Mediat 2018 Nov 6;140:9-17. Epub 2018 Nov 6.

Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China; Jiangxi Province Key Laboratory of Tumor Etiology and Molecular Pathology, Nanchang 330006, China. Electronic address:

Background: The renin angiotensin-aldosterone system (RAAS) and lipoxins (LXs) have similar roles in many processes. We previously reported that BML-111, a Lipoxin receptor agonist, inhibited chronic injury hepatic fibrosis by regulating RAAS, but whether LXs are involved in BML-111-mediated protection from acute injury is unclear still.

Methods: We established models of acute liver/lung injury and confirmed them with histopathology and myeloperoxidase (MPO) measurements. Read More

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November 2018
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Expression profiles of interferon-stimulated gene 15 and prostaglandin synthases in the ovine lymph nodes during early pregnancy.

Mol Reprod Dev 2018 Nov 8. Epub 2018 Nov 8.

College of Life Sciences and Food Engineering, Hebei University of Engineering, Handan, China.

Lymph nodes are distributed all over the body and are part of the lymphatic system. The interferon-stimulated gene 15 kDa protein (ISG15) and prostaglandins (PGs) are involved in the establishment of pregnancy and are expressed in the uterus during early pregnancy in sheep. In this study, the ovine lymph nodes were obtained on Day 16 of the estrous cycle, and Days 13, 16, and 25 of pregnancy, and the expression of ISG15 and PG synthases, including cyclooxygenase 1 (COX-1), COX-2, prostaglandin E (PGE) synthase (PTGES), and a PGF synthase (aldo-keto reductase family 1, member B1, AKR1B1) were detected by quantitative real-time polymerase chain reaction, western blot analysis, and immunohistochemistry analysis. Read More

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November 2018
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Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.

J Toxicol Sci 2018 ;43(11):671-684

Physiology Department, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, Mexico.

Thalidomide was originally developed to treat primary neurological and psychiatric diseases. There are reports of anticonvulsant effects of thalidomide in rats and antiepileptic effects in patients. Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine. Read More

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November 2018
6 Reads