112,247 results match your criteria Prostaglandins & Other Lipid Mediators[Journal]


Effect of systemic antihypertensives on change in intraocular pressure after initiating topical prostaglandins for primary open-angle glaucoma.

Clin Ophthalmol 2019 23;13:207-213. Epub 2019 Jan 23.

Medical Center Ophthalmology Associates, San Antonio, TX, USA,

Purpose: There is a limited understanding of factors that influence the efficacy of topical glaucoma medication. Our study is a long-term, case-control analysis of how systemic antihypertensive (anti-HTN) medications influence the change in IOP after initiating prostaglandin (PG) drop therapy.

Materials And Methods: A retrospective chart review of 3,781 patients was performed on patients with a diagnosis of glaucoma suspect that progressed to primary open-angle glaucoma (POAG) by ICD-9 codes over a 10-year period. Read More

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http://dx.doi.org/10.2147/OPTH.S192010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350645PMC
January 2019

Association of reported fish intake and supplementation status with the omega-3 index.

Prostaglandins Leukot Essent Fatty Acids 2019 Mar 11;142:4-10. Epub 2019 Jan 11.

OmegaQuant, LLC, 5009W. 12th St., Suite 8, Sioux Falls, SD 57106, United States; Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States.

Background: An Omega-3 Index (O3I; EPA+DHA as a % of erythrocyte total fatty acids) in the desirable range (8%-12%) has been associated with improved heart and brain health.

Objective: To determine the combination of fish intake and supplement use that is associated with an O3I of >8%.

Design: Two cross-sectional studies comparing the O3I to EPA+DHA/fish intake. Read More

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http://dx.doi.org/10.1016/j.plefa.2019.01.002DOI Listing

How the plasma lysophospholipid and unesterified fatty acid pools supply the brain with docosahexaenoic acid.

Prostaglandins Leukot Essent Fatty Acids 2019 Mar 25;142:1-3. Epub 2018 Dec 25.

Univ-Lyon, Inserm UMR 1060, Inra UMR 1397, INSA-Lyon, IMBL, 20 Ave A., Einstein, 69100 Villeurbanne, France.

The brain requires a constant supply of docosahexaenoic acid (DHA) from blood to maintain DHA levels within the brain. Several plasma pools have been proposed to supply the brain with DHA, including plasma lipoproteins, lysophosphatidylcholine and unesterified fatty acids. Here we briefly review the evidence for each plasma pool supplying the brain highlighting controversies and remaining questions. Read More

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http://dx.doi.org/10.1016/j.plefa.2018.12.003DOI Listing

Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats.

BMC Pharmacol Toxicol 2019 Feb 15;20(1):13. Epub 2019 Feb 15.

Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: Basic function of bromine in body is to activate pepsin production in gastritis with low acidity. The present study encompasses a broad in vivo study to evaluate gastroprotective activity of a novel dibromo substituted Schiff base complex against Sprague Dawley (SD) rats.

Methods: 2, 2'-[1, 2-cyclohexanediylbis (nitriloethylidyne)]bis(4-bromophenol) (CNBP) is synthesized via a Schiff base reaction, using the related ketone and diamine as the starting materials. Read More

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http://dx.doi.org/10.1186/s40360-019-0292-zDOI Listing
February 2019
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A strategy for validating concentrations of oxylipin standards for external calibration.

Prostaglandins Other Lipid Mediat 2019 Feb 12;141:22-24. Epub 2019 Feb 12.

Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany. Electronic address:

Quantitative analysis of oxylipins by means of chromatography/mass spectrometry is based on (external) calibration with standard compounds. Therefore, the quality of analytical standards is of fundamental importance for accurate results. Recently launched certified standards with an assured concentration within a narrow range are useful tools to verify analytical standards. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.02.006DOI Listing
February 2019

Metabolic studies of synaptamide in an immortalized dopaminergic cell line.

Prostaglandins Other Lipid Mediat 2019 Feb 11;141:25-33. Epub 2019 Feb 11.

Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States.

Introduction: Synaptamide, the N-acylethanolamine of docosahexaenoic acid (DHA), is structurally similar to the endocannabinoid N-arachidonoylethanolamine, anandamide. It is an endogenous ligand at the orphan G-protein coupled receptor 110 (GPR110; ADGRF1), and induces neuritogenesis and synaptogenesis in hippocampal and cortical neurons, as well as neuronal differentiation in neural stem cells.

Purpose: Our goal was to characterize the metabolic fate (synthesis and metabolism) of synaptamide in a dopaminergic cell line using immortalized fetal mesencephalic cells (N27 cells). Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.02.002DOI Listing
February 2019

Effects of nonsteroidal anti-inflammatory drugs on the expression of arachidonic acid-metabolizing Cyp450 genes in mouse hearts, kidneys and livers.

Prostaglandins Other Lipid Mediat 2019 Feb 11;141:14-21. Epub 2019 Feb 11.

Department of Pharmacy, College of Pharmacy, AlZaytoonah University of Jordan, Amman, Jordan.

Arachidonic acid (ARA) metabolites are involved in cardiovascular diseases and drug-induced cardiotoxicity. The present study aimed to investigate the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the gene expression of ARA-metabolizing cyp450 genes in the hearts, kidneys and livers of experimental mice. Thirty five Balb/c mice were divided into 5 groups, and each group contained 7 mice. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.02.003DOI Listing
February 2019

Abnormal amygdala resting-state functional connectivity in primary dysmenorrhea.

Neuroreport 2019 Feb 11. Epub 2019 Feb 11.

Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine.

Neuroimaging studies have manifested functional abnormalities in pain-related brain regions in patients with primary dysmenorrhea (PDM). However, as the key region in brain pain matrix, whether and how the amygdala functional network alteration in PDM is unclear. In this study, we aimed to investigate the intrinsic amygdala functional connectivity (AFC) network alteration in patients with PDM during ovulatory period. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001208DOI Listing
February 2019

Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls.

Molecules 2019 Feb 11;24(3). Epub 2019 Feb 11.

Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Santo Tomás, Delegación Miguel Hidalgo, Ciudad de México 11340, Mexico.

Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from ), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0. Read More

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http://dx.doi.org/10.3390/molecules24030622DOI Listing
February 2019

Cyclooxygenase-2 in gastrointestinal malignancies.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Cyclooxygenase (COX) is an enzyme complex that plays an important role in the conversion of arachidonic acid to prostaglandins. Prostaglandins are essential modulators of signal transduction pathways, which contribute to the metastatic properties of gastrointestinal (GI) malignancies. Although COX-1 is constitutively active, COX-2 is upregulated by cytokines, growth factors, and mitogen. Read More

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http://dx.doi.org/10.1002/cncr.32010DOI Listing
February 2019

Sublingual vs vaginal misoprostol for completion of first trimester missed abortion: a randomised controlled trial.

Eur J Contracept Reprod Health Care 2019 Feb 12:1-6. Epub 2019 Feb 12.

b Women's Health Hospital, Faculty of Medicine , Assiut University , Assiut , Egypt.

Objective: The study aimed to compare the efficacy and safety of sublingual and vaginal misoprostol for termination of pregnancy in women with first trimester missed abortion.

Methods: A single-blind, parallel group, randomised clinical trial (ClinicalTrials.gov NCT02686840) was conducted in a university hospital between 1 February 2016 and 31 January 2017. Read More

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http://dx.doi.org/10.1080/13625187.2019.1569224DOI Listing
February 2019

Comparison of intracervical Foley catheter used alone or combined with a single dose of dinoprostone gel for cervical ripening: a randomised study.

J Obstet Gynaecol 2019 Feb 12:1-7. Epub 2019 Feb 12.

b Department of Neonatology , Post Graduate Institute of Medical Education & Research , Chandigarh , India.

Prostaglandins and intracervical catheters are similarly effective for cervical ripening and for an induction of labour (IOL). Studies comparing the combined use with either method alone have administered repetitive doses of prostaglandins vaginally, which may increase the risk of tachysystole and chorioamnionitis. These disadvantages may be offset by co-administering a single dose of prostaglandin. Read More

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http://dx.doi.org/10.1080/01443615.2018.1534090DOI Listing
February 2019
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Physiological and pathological levels of prostaglandin E in renal parenchyma and neoplastic renal tissue.

Prostaglandins Other Lipid Mediat 2019 Feb 10;141:11-13. Epub 2019 Feb 10.

Department of Urology, ASL Abruzzo2, Via dei Vestini, Chieti, Italy.

Prostaglandin (PG)E seems to promote tumor proliferation by regulating cell growth, inhibiting apoptosis, promoting angiogenesis, and suppressing host immune surveillance of cancer cells. The suppression of prostaglandins biosynthesis is thought to be the main molecular mechanism for non-steroidal anti-inflammatory drugs antineoplastic effect. Yet the relationship between PGE and human renal cell carcinoma remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10988823183016
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http://dx.doi.org/10.1016/j.prostaglandins.2019.02.004DOI Listing
February 2019
2 Reads

Phospho-substrate profiling of Epac-dependent protein kinase C activity.

Mol Cell Biochem 2019 Feb 9. Epub 2019 Feb 9.

Department of Biomedical Sciences, University of New England, 11 Hills Beach Rd, Biddeford, ME, 04005, USA.

Exchange protein directly activated by cAMP (Epac) and protein kinase A are effectors for cAMP with distinct actions and regulatory mechanisms. Epac is a Rap guanine nucleotide exchange factor that activates Rap1; protein kinase C (PKC) is a major downstream target of Epac-Rap1 signaling that has been implicated in a variety of pathophysiological processes, including cardiac hypertrophy, cancer, and nociceptor sensitization leading to chronic pain. Despite the implication of both Epac and PKC in these processes, few downstream targets of Epac-PKC signaling have been identified. Read More

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http://dx.doi.org/10.1007/s11010-019-03502-1DOI Listing
February 2019
1 Read

Oral cholecalciferol supplementation alleviates lipopolysaccharide-induced preterm delivery partially through regulating placental steroid hormones and prostaglandins in mice.

Int Immunopharmacol 2019 Feb 7;69:235-244. Epub 2019 Feb 7.

Department of Toxicology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Environmental Toxicology, Anhui Higher Education Institutes, Anhui Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei 230032, China. Electronic address:

Several epidemiological reports demonstrated that vitamin D deficiency elevated risk of preterm delivery. We investigate the effects of oral cholecalciferol (VD3) supplementation on lipopolysaccharide (LPS)-induced preterm delivery. Pregnant mice were randomly assigned to either oral VD3 (25 μg/kg) or corn oil once daily from gestational day (GD)13 to GD15, and were intraperitoneally injected with either LPS (200 μg/kg) or normal saline on GD15. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.052DOI Listing
February 2019

Leukotriene B modulation of murine dendritic cells affects adaptive immunity.

Prostaglandins Other Lipid Mediat 2019 Feb 7. Epub 2019 Feb 7.

Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

Dendritic cells (DCs) link innate and adaptive immunity. The microenvironment generated during the innate immunity affects DCs and the type of adaptive immunity generated. Lipid mediators are released early in inflammation and could modify the functional state of DCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10988823183011
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http://dx.doi.org/10.1016/j.prostaglandins.2019.02.001DOI Listing
February 2019
1 Read

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression.

Life Sci Alliance 2019 Feb 8;2(1). Epub 2019 Feb 8.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA

The impact of mitochondrial dysfunction in epigenetics is emerging, but our understanding of this relationship and its effect on gene expression remains incomplete. We previously showed that acute mitochondrial DNA (mtDNA) loss leads to histone hypoacetylation. It remains to be defined if these changes are maintained when mitochondrial dysfunction is chronic and if they alter gene expression. Read More

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http://dx.doi.org/10.26508/lsa.201800228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369536PMC
February 2019

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.

FASEB J 2019 Feb 8:fj201802509R. Epub 2019 Feb 8.

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena, Germany.

Nonsteroidal anti-inflammatory drugs interfere with the metabolism of arachidonic acid to proinflammatory prostaglandins and leukotrienes by targeting cyclooxygenases (COXs), 5-lipoxygenase (LOX), or the 5-LOX-activating protein (FLAP). These and related enzymes act in conjunction with marked crosstalk within a complex lipid mediator (LM) network where also specialized proresolving LMs (SPMs) are formed. Here, we present how prominent LM pathways can be differentially modulated in human proinflammatory M1 and proresolving M2 macrophage phenotypes that, upon exposure to Escherichia coli, produce either abundant prostaglandins and leukotrienes (M1) or SPMs (M2). Read More

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http://dx.doi.org/10.1096/fj.201802509RDOI Listing
February 2019

Prostaglandins E and F levels in human menstrual fluid by online Solid Phase Extraction coupled to Liquid Chromatography tandem Mass Spectrometry (SPE-LC-MS/MS).

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 29;1109:60-66. Epub 2019 Jan 29.

Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luís, km 235, SP-310, São Carlos, SP 13565-905, Brazil. Electronic address:

This paper reports an online SPE-LC-MS/MS method for the simultaneous quantification of prostaglandins (PGE and PGF) in menstrual fluid samples. To meet this goal human peripheral serum was used as surrogate matrix. The analytes were trapped on an OASIS HLB cartridge for 3 min, for sample cleanup and enrichment, and then transferred during only 42 s to an HSS T3 C18 analytical column, for separation and analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183138
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http://dx.doi.org/10.1016/j.jchromb.2019.01.025DOI Listing
January 2019
2 Reads

Prostaglandins in androgenetic alopecia in 12 men and 4 female.

J Eur Acad Dermatol Venereol 2019 Feb 7. Epub 2019 Feb 7.

Universidad Autónoma de Nuevo León, Facultad de Medicina, Departamento de Dermatología, Monterrey, Mexico.

Androgenetic alopecia (AGA) is the most common form of hair loss in humans. Evidence suggests the participation of prostaglandins in the development of AGA. The aim of this study was to analyze the expression of the PTGDR2 (GPR44 receptor), PTGDS (Prostaglandin D2 synthase), and PTGES (Prostaglandin E synthase) transcripts in biopsies from balding scalp of hispanic patients with AGA and female androgenetic alopecia (FAGA). Read More

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http://dx.doi.org/10.1111/jdv.15479DOI Listing
February 2019

Induction of labor methods in isolated term oligohydramnios.

Arch Gynecol Obstet 2019 Feb 7. Epub 2019 Feb 7.

Rabin Medical Center, Helen Schneider Hospital for Women, 39 Zabotinski St, 4941492, Petach Tikva, Israel.

Objective: To compare pregnancy outcomes following induction of labor with prostaglandins versus extra-amniotic balloon catheter indicated for term isolated oligohydramnios.

Study Design: Retrospective cohort study of all women who underwent induction of labor due to term isolated oligohydramnios at a university affiliated medical center (2007-2016). The cohort was divided into two subgroups, according to induction method: vaginal prostaglandins E2 versus extra-amniotic balloon catheter. Read More

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http://dx.doi.org/10.1007/s00404-019-05080-5DOI Listing
February 2019
1 Read

Glycerolipid Composition of the Red Macroalga and Comparison to the Closely Related Producing Different Types of Eicosanoids.

Mar Drugs 2019 Feb 2;17(2). Epub 2019 Feb 2.

Callaghan Innovation, 69 Gracefield Road, P.O. Box 31310, Lower Hutt 5040, New Zealand.

The red macroalga is a well-known producer of eicosanoids such as hydroxyeicosatetraenoic acids, but the alga produces almost no prostaglandins, unlike the closely related . This indicates that the related two algae would have different enzyme systems or substrate composition. To carry out more in-depth discussions on the metabolic pathway of eicosanoids between the two algae, we investigated the characteristics of glycerolipids, which are the substrates of eicosanoids production, of and compared them to the reported values of . Read More

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http://dx.doi.org/10.3390/md17020096DOI Listing
February 2019

[Case report of 39-Year-Old Gravida III, Para III with Inverted Uterus after Breech Birth].

Z Geburtshilfe Neonatol 2019 Feb 4. Epub 2019 Feb 4.

Universitätsklinik für Frauenheilkunde, Geburtshilfe und Reproduktionsmedizin, Universitätsklinikum Magdeburg, Magdeburg.

An inverted uterus is defined as the eversion of the uterus into the vagina. It is a very rare event but has to be treated as an emergency. A woman with an inverted uterus is in serious danger of developing atony with high blood loss in a short time. Read More

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http://dx.doi.org/10.1055/a-0828-8696DOI Listing
February 2019
1 Read

Simultaneous determination of androgens and prostaglandins in human urine using ultra-high-performance liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 28;1109:45-53. Epub 2019 Jan 28.

Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Department of Converging Science and Technology, Kyung Hee University, 02447 Seoul, Republic of Korea. Electronic address:

A simultaneous quantitative profiling method for androgens and prostaglandins using ultra-high-performance liquid chromatography-tandem mass spectrometry was developed and validated to evaluate urinary androgen and prostaglandin levels. Solid-phase extraction and liquid-liquid extraction steps were combined during the sample preparation. β-Glucuronidase/arylsulfatase was also used in the enzyme hydrolysis step. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.01.022DOI Listing
January 2019

Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation.

Biochimie 2019 Feb 1. Epub 2019 Feb 1.

Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA. Electronic address:

Neuroinflammation is a physiologic response aimed at protecting the central nervous system during injury. However, unresolved and chronic neuroinflammation can lead to long term damage and eventually neurologic disease including Parkinson's disease, Alzheimer's disease and dementia. Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.01.020DOI Listing
February 2019
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Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O Sensitive Voltage-Gated K Channels.

Front Pharmacol 2018 18;9:1518. Epub 2019 Jan 18.

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are not fully elucidated in relation to receptor subtype and effects on O sensitive Kv channels. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2018.01518
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http://dx.doi.org/10.3389/fphar.2018.01518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346678PMC
January 2019
4 Reads

Symposium review: Immunological detection of the bovine conceptus during early pregnancy.

Authors:
Troy L Ott

J Dairy Sci 2019 Jan 31. Epub 2019 Jan 31.

Department of Animal Science, Center for Reproductive Biology and Health, Huck Institutes of the Life Science, Pennsylvania State University, University Park 16802. Electronic address:

Infertility and subfertility reduce the economic viability of dairy production. Inflammation reduces conception rates in dairy cattle, but surprisingly little information exists about the populations and the functions of immune cells at the conceptus-maternal interface during the periattachment period in dairy cattle. Early pregnancy is accompanied by immune stimulation at insemination and conceptus secretion of IFN-τ, pregnancy-associated glycoproteins, prostaglandins, and other molecules whose effects on immune function during early pregnancy have not been determined. Read More

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http://dx.doi.org/10.3168/jds.2018-15668DOI Listing
January 2019
2 Reads

effect of methanolic extract on stress-induced gastric ulcers in rats.

Arch Med Sci 2019 Jan 19;15(1):223-231. Epub 2016 Oct 19.

Department of Pharmacology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.

Introduction: (Piperaceae) is traditionally used by Asians to treat numerous common ailments including asthma, fever and gastritis. The aim of the research was to determine and compare the effects of Piper sarmentosum (PS) with omeprazole (OMZ) on gastric parameters in rats exposed to restraint stress.

Material And Methods: The methanolic extract of PS was prepared in the dose of 500 mg/kg. Read More

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http://dx.doi.org/10.5114/aoms.2016.63156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348366PMC
January 2019
3 Reads

LC-MS/MS analyses of open flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation.

J Lipid Res 2019 Jan 29. Epub 2019 Jan 29.

Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft mbH, Austria;

Eicosanoids are lipid mediator molecules with key roles in inflammatory skin diseases such as psoriasis. Eicosanoids are released close to the source of inflammation where they elicit local, pleiotropic effects and dysregulations. Monitoring inflammatory mediators directly in skin lesions could provide new insights and new therapeutic possibilities. Read More

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http://dx.doi.org/10.1194/jlr.M087221DOI Listing
January 2019

Does aerobic exercise induced-analgesia occur through hormone and inflammatory cytokine-mediated mechanisms in primary dysmenorrhea?

Med Hypotheses 2019 Feb 21;123:50-54. Epub 2018 Dec 21.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

The popular accepted explanation for the pathogenesis of primary dysmenorrhea is elevated levels of uterine prostaglandins. Aetiological studies report that production of prostaglandins is controlled by the sex hormone progesterone, with prostaglandins and progesterone displaying an inverse relationship (i.e. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.12.011DOI Listing
February 2019
1 Read

The relatively selective cyclooxygenase-2 inhibitor nimesulide: What's going on?

Eur J Pharmacol 2019 Jan 25;848:105-111. Epub 2019 Jan 25.

Department of Pharmacy, School of Medicine, University of Naples Federico II, via Domenico Montesano, 49, 80131 Naples, Italy. Electronic address:

Nimesulide is a relatively selective cyclooxygenase (COX)-2 inhibitor, non-steroidal anti-inflammatory drug; it has been discovered in 1971 and firstly commercialized in Italy in 1985. There is much evidence that the pharmacological profile of nimesulide is peculiar and not shared with the other COX-2 selective inhibitors, suggesting that other molecular mechanisms besides inhibition of COX-2 derived prostaglandins are involved. Similarly, experimental data suggest that the gastrointestinal safety of nimesulide cannot be ascribed only to a COX-1 sparing effect. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.01.044DOI Listing
January 2019

The cyclooxygenase-2/prostaglandin E pathway and its role in the pathogenesis of human and dog hematological malignancies.

J Physiol Pharmacol 2018 Oct 21;69(5). Epub 2019 Jan 21.

Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.

The overexpression of cyclooxygenase-2 (COX-2) has been documented in many types of cancer occurring in humans and animals. Increasing evidences have shown that the overexpression of COX-2 and increased production of prostaglandin E (PGE) correlate with poor prognosis in human solid tumours and hematological malignancies. Both, in vitro and in vivo studies have demonstrated that increased proliferation of cancer cells as well as an impairment of anti-tumour immunity are influenced by the overexpression of this enzyme. Read More

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http://dx.doi.org/10.26402/jpp.2018.5.01DOI Listing
October 2018
2 Reads

Changes in glaucoma medication numbers after cataract and glaucoma surgery: A nationwide population-based study.

Medicine (Baltimore) 2019 Jan;98(4):e14128

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine.

To determine whether cataract or glaucoma and combined cataract and glaucoma surgery (CGS) affect glaucoma medication usage.We recruited patients who received new diagnoses of glaucoma, either primary open-angle glaucoma (POAG) (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] code 365.1) or primary angle-closure glaucoma (PACG) (ICD-9-CM code 365. Read More

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http://dx.doi.org/10.1097/MD.0000000000014128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358407PMC
January 2019
1 Read

Eicosanoids in tissue repair.

Immunol Cell Biol 2019 Jan 24. Epub 2019 Jan 24.

Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, 80802, Munich, Germany.

Trauma or infection can result in tissue damage, which needs to be repaired in a well-orchestrated manner to restore tissue function and homeostasis. Lipid mediators derived from arachidonic acid (termed eicosanoids) play central and versatile roles in the regulation of tissue repair. Here, I summarize the current state-of the-art regarding the functional activities of eicosanoids in tissue repair responses during homeostasis and disease. Read More

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http://dx.doi.org/10.1111/imcb.12226DOI Listing
January 2019
1 Read

Effects of arachidonic acid and its major prostaglandin derivatives on bovine myoblast proliferation, differentiation, and fusion.

Authors:
X Leng H Jiang

Domest Anim Endocrinol 2018 Dec 19;67:28-36. Epub 2018 Dec 19.

Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address:

Many studies have shown positive effects of prostaglandins (PGs) on various steps of skeletal muscle formation such as myoblast proliferation and myotube hypertrophy. In animals, PGs are synthesized through the action of the rate-limiting enzymes cyclooxygenase (COX) -1 and COX-2 from arachidonic acid (AA), a conditionally essential fatty acid. As a step toward exploring the possibility of using dietary supplementation of AA to improve skeletal muscle growth in cattle, which are major meat-producing animals, we determined the effects of AA and its major PG derivatives PGE, PGF, and PGI on proliferation, differentiation, and fusion of primary bovine myoblasts in vitro. Read More

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http://dx.doi.org/10.1016/j.domaniend.2018.12.006DOI Listing
December 2018
5 Reads

4-methoxycinnamyl p-coumarate isolated from Etlingera pavieana rhizomes inhibits inflammatory response via suppression of NF-κB, Akt and AP-1 signaling in LPS-stimulated RAW 264.7 macrophages.

Phytomedicine 2018 Sep 18;54:89-97. Epub 2018 Sep 18.

Department of Biochemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand. Electronic address:

Background: 4-methoxycinnamyl p-coumarate (MCC) was isolated from rhizomes of Etlingera pavieana by bioactivity-guided isolation, however, the molecular mechanism underlying its anti-inflammatory activity remains inadequately understood.

Purpose: In this study, we elucidated the suppressive effect of MCC on LPS-induced expression of inflammatory mediators and the molecular mechanisms responsible for anti-inflammatory activities in RAW 264.7 macrophages. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183047
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http://dx.doi.org/10.1016/j.phymed.2018.09.193DOI Listing
September 2018
7 Reads

Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis.

Allergy 2019 Jan 22. Epub 2019 Jan 22.

Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.

Background: Eosinophils are multifunctional granulocytes capable of releasing various cytokines, chemokines, and lipid mediators. We previously reported dysregulated fatty acid metabolism in peripheral blood-derived eosinophils from patients with severe asthma. However, functional characteristics of eosinophils present in allergic inflammatory tissues remains largely uncharacterized. Read More

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http://dx.doi.org/10.1111/all.13726DOI Listing
January 2019
4 Reads

15 keto fluprostenol isopropyl ester (80 µgr/mL) gel for cosmetic eyelash growth and enhancement.

J Cosmet Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.

Background: Eyelashes have both a protective and an aesthetic function. Hypotrichosis of the eyelashes may negatively influence an individual's self-perception.

Objective: To evaluate efficacy and safety of topical administration of a new cosmetic preparation containing 15 keto fluprostenol isopropyl ester (80 µgr/mL) for the treatment of idiopathic hypotrichosis of the eyelashes. Read More

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http://dx.doi.org/10.1111/jocd.12844DOI Listing
January 2019
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Interleukin-1β and prostaglandin-synthesizing enzymes as modulators of human omental and subcutaneous adipose tissue function.

Prostaglandins Leukot Essent Fatty Acids 2019 Feb 29;141:9-16. Epub 2018 Nov 29.

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec, QC, Canada; École de nutrition - Université Laval, Québec, QC, Canada; Centre hospitalier universitaire de Québec - Université Laval, Québec, QC, Canada. Electronic address:

IL-1β stimulates expression of prostaglandin (PG)-synthesizing enzymes cyclooxygenase (COX)-2 and aldo-keto reductase (AKR)1B1 in human preadipocytes. We aimed to examine the impact of IL-1β, COX-2 and AKR1B1 on markers of human visceral and subcutaneous adipose tissue function, and to assess whether PG synthesis by these enzymes mediates IL-1β effects. Omental and subcutaneous fat samples were obtained from bariatric surgery patients. Read More

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http://dx.doi.org/10.1016/j.plefa.2018.11.015DOI Listing
February 2019
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Adipose tissue oxylipin profiles vary by anatomical site and are altered by dietary linoleic acid in rats.

Prostaglandins Leukot Essent Fatty Acids 2019 Feb 27;141:24-32. Epub 2018 Dec 27.

Department of Food and Human Nutritional Sciences, University of Manitoba, Canada; Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, Canada. Electronic address:

Dietary PUFA and their effects on adipose tissue have been well studied, but oxylipins, the oxygenated metabolites of PUFA, have been sparsely studied in adipose tissue. To determine the oxylipin profile and to examine their potential importance in various adipose sites, female and male rats were provided control, high linoleic acid (LA), or high LA and high α-linolenic acid (LA + ALA) diets for six weeks. Analysis of gonadal (GAT), mesenteric (MAT), perirenal (PAT), and subcutaneous adipose tissues (SAT) revealed higher numbers of oxylipins in MAT and SAT, primarily due to 20-22 carbon cytochrome P450 oxylipins, as well as metabolites of cyclooxygenase derived oxylipins. Read More

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http://dx.doi.org/10.1016/j.plefa.2018.12.004DOI Listing
February 2019
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Characterization of cysteinyl leukotriene-related receptors and their interactions in a mouse model of asthma.

Prostaglandins Leukot Essent Fatty Acids 2019 Feb 12;141:17-23. Epub 2018 Dec 12.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea. Electronic address:

Identification of the characterization of cysteinyl leukotrienes receptor (CysLTRs) could facilitate our understanding of these receptors' role in asthma. We aimed to investigate the localization and interactions of CysLTRs using a mouse model of asthma. BALB/c mice were administered ovalbumin (OVA) to induce allergic asthma. Read More

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http://dx.doi.org/10.1016/j.plefa.2018.12.002DOI Listing
February 2019
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Lowering the linoleic acid to alpha-linoleic acid ratio decreases the production of inflammatory mediators by cultured human endothelial cells.

Prostaglandins Leukot Essent Fatty Acids 2019 Feb 12;141:1-8. Epub 2018 Dec 12.

Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom.

Alpha-linolenic acid (ALA) and linoleic acid (LA) are precursors for longer-chain more unsaturated fatty acids and for lipid signalling molecules that may influence inflammatory processes through a variety of mechanisms. The actions of LA and ALA may be divergent and interdependent. The aim of this study was to investigate the incorporation and metabolism of ALA and LA in cultured in EA. Read More

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http://dx.doi.org/10.1016/j.plefa.2018.12.001DOI Listing
February 2019
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Vimentin disruption by lipoxidation and electrophiles: Role of the cysteine residue and filament dynamics.

Redox Biol 2019 Jan 8:101098. Epub 2019 Jan 8.

Department of Structural and Chemical Biology, Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address:

The intermediate filament protein vimentin constitutes a critical sensor for electrophilic and oxidative stress, which induce extensive reorganization of the vimentin cytoskeletal network. Here, we have investigated the mechanisms underlying these effects. In vitro, electrophilic lipids, including 15-deoxy-Δ-prostaglandin J (15d-PGJ) and 4-hydroxynonenal (HNE), directly bind to vimentin, whereas the oxidant diamide induces disulfide bond formation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183101
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http://dx.doi.org/10.1016/j.redox.2019.101098DOI Listing
January 2019
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Upregulation of cystathionine-γ-lyase/hydrogen sulfide pathway underlies the celecoxib counteraction of cyclosporine-induced hypertension and renal insult in rats.

Prostaglandins Other Lipid Mediat 2019 Jan 15;141:1-10. Epub 2019 Jan 15.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Egypt. Electronic address:

We recently reported that celecoxib, a selective cyclooxygenase-2 (COX2) inhibitor, counteracts the adverse circulatory and renal actions of cyclosporine (CSA). Despite the seemingly advantageous nature of this interaction particularly in clinical settings that necessitate the combined use of the two drugs such as immune-related arthritis, the underlying mechanism remains elusive. This prompted us to test the hypothesis that the facilitation of the cystathionine-γ-lyase (CSE)/hydrogen sulfide (HS) signaling accounts for such favorable effects of celecoxib on CSA nephrotoxicity. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.01.001DOI Listing
January 2019
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Influence of Maternal Obesity on Labor Induction: A Systematic Review and Meta-Analysis.

J Midwifery Womens Health 2019 Jan 16;64(1):55-67. Epub 2019 Jan 16.

Introduction: Studies have shown that women with obesity have longer labors. The purpose of this systematic review and meta-analysis is to examine existing evidence regarding labor induction in women with obesity, including processes and outcomes. The primary outcome was cesarean birth following labor induction. Read More

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http://dx.doi.org/10.1111/jmwh.12935DOI Listing
January 2019
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Prostaglandin A1 Inhibits the Cognitive Decline of APP/PS1 Transgenic Mice via PPARγ/ABCA1-dependent Cholesterol Efflux Mechanisms.

Neurotherapeutics 2019 Jan 9. Epub 2019 Jan 9.

College of Life and Health Sciences, Northeastern University, No. 3-11. Wenhua Road, Shenyang, 110819, People's Republic of China.

Prostaglandins (PGs) are early and key contributors to chronic neurodegenerative diseases. As one important member of classical PGs, PGA1 has been reported to exert potential neuroprotective effects. However, the mechanisms remain unknown. Read More

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http://dx.doi.org/10.1007/s13311-018-00704-1DOI Listing
January 2019
1 Read