112,546 results match your criteria Prostaglandins & Other Lipid Mediators[Journal]


Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress.

Prostaglandins Other Lipid Mediat 2019 Apr 19. Epub 2019 Apr 19.

Institute for Food Toxicology, University of Veterinary Medicine Hannover, Hannover, Germany; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany. Electronic address:

In mammals, epoxy-polyunsaturated fatty acids (epoxy-PUFA) are enzymatically formed from naturally occurring all-cis PUFA by cytochrome P450 monooxygenases leading to the generation of cis-epoxy-PUFA (mixture of R,S- and S,R-enantiomers). In addition, also non-enzymatic chemical peroxidation gives rise to epoxy-PUFA leading to both, cis- and trans-epoxy-PUFA (mixture of R,R- and S,S-enantiomers). Here, we investigated for the first time trans-epoxy-PUFA and the trans/cis-epoxy-PUFA ratio as potential new biomarker of lipid peroxidation. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.04.004DOI Listing

Tetralogy of Fallot with absent pulmonary valve-When the ductus is present: A case of isolated branch pulmonary artery and review of literature.

Echocardiography 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatric Cardiology, Cleveland Clinic Children's Hospital, Cleveland, Ohio.

Tetralogy of Fallot/Absent Pulmonary Valve (TOF/APV) has been classically associated with the absence of a patent ductus arteriosus (PDA). We present a rare case of APV in TOF with a discontinuous left pulmonary artery (LPA) that was suspected during fetal echocardiogram. Postnatal echocardiogram confirmed the origin of a hypoplastic LPA from the PDA. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/echo.14334
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http://dx.doi.org/10.1111/echo.14334DOI Listing
April 2019
1 Read

Myeloid cell mPges-1 depletion attenuates mortality without affecting remodeling after acute myocardial infarction in mice.

J Pharmacol Exp Ther 2019 Apr 16. Epub 2019 Apr 16.

University of Pennsylvania;

Selective deletion of microsomal PGE2 synthase (mPGES) -1 in myeloid cells retards atherogenesis and suppresses the vascular proliferative response to injury, while it does not predispose to thrombogenesis or hypertension. However, studies using bone marrow transplants from irradiated mice suggest that myeloid cell mPGES-1 facilitates cardiac remodeling and prolongs survival after experimental myocardial infarction (MI). Here we addressed this question using mice lacking mPges-1 in myeloid cells, particularly macrophages (Mac-mPges-1 KO), generated by crossing mPges-1 floxed mice with LysMCre mice, and subjecting them to coronary artery ligation. Read More

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http://dx.doi.org/10.1124/jpet.118.256057DOI Listing
April 2019
1 Read

Resynchronisation as an Element of Improving Cattle Reproduction Efficiency.

J Vet Res 2019 Mar 22;63(1):107-115. Epub 2019 Mar 22.

Veterinary Centre of Nicolaus Copernicus University, 87-100 Toruń, Poland.

Oestrus resynchronisation (RES, Resynch) programmes for non-pregnant cows allow shortening the period between an unsuccessful insemination and the next attempt on the same cow. The protocol of oestrus RES may be started after ruling out pregnancy by means of ultrasonography carried out 28 days after insemination or after performing a test for pregnancy-specific glycoproteins (PAG) in blood or milk. The Resynch protocol can be based on a double application of prostaglandins, the OvSynch protocol, or hormonal therapy with exogenous sources of progesterone (CIDR intravaginal devices). Read More

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http://dx.doi.org/10.2478/jvetres-2019-0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458552PMC
March 2019
1 Read

Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells.

Phytomedicine 2019 Mar 10:152881. Epub 2019 Mar 10.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

Introduction: The adaptogens modulate expression of genes playing key roles in development of aging-related disorders, which are considered as low-grade systemic inflammatory conditions characterized by an imbalance between pro-and anti-inflammatory eicosanoids.

Aim Of The Study: We compared the effects of anti-inflammatory and adaptogenic plant extracts on the expression of genes involved in biosynthesis of eicosanoids with the purpose to find those plants, which selectively upregulated the expression of anti-inflammatory lipoxins signaling pathways and inhibited pro-inflammatory signaling pathways associated with biosynthesis of leukotrienes, prostaglandins and thromboxanes.

Materials And Methods: We conducted transcriptome-wide RNA sequencing to profile gene expression alterations in T98G neuroglia cells upon treatment of plant extract and analyzed the relevance of deregulated genes to eicosanoids signaling pathways using in silico models. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.152881DOI Listing
March 2019
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Effects of photobiomodulation therapy on inflammatory mediators in patients with chronic non-specific low back pain: Protocol for a randomized placebo-controlled trial.

Medicine (Baltimore) 2019 Apr;98(15):e15177

Physiotherapy Research Group, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Introduction: Low back pain (LBP) is ranked as one of the most prevalent health conditions. It is likely that some inflammatory mediators could be associated with pain and disability in these patients. Photobiomodulation therapy (PBMT) is a non-pharmacological therapy often used in patients with LBP and one of the possible mechanisms of action of therapy is modulate inflammatory mediators. Read More

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http://dx.doi.org/10.1097/MD.0000000000015177DOI Listing
April 2019
1 Read

Prostaglandins and cesarean delivery for nonreassuring fetal status in patients delivering small-for-gestational age neonates at term.

J Matern Fetal Neonatal Med 2019 Apr 24:1-7. Epub 2019 Apr 24.

a Department of Obstetrics and Gynecology , Washington University School of Medicine in St. Louis , St. Louis , MO , USA.

Objective: Growth-restricted fetuses have been excluded from many randomized trials of prostaglandins for labor induction. As prostaglandins, particularly misoprostol, are associated with increased rates of cesarean delivery for nonreassuring fetal heart tracing, it is important to assess their safety in pregnancies at higher risk of this complication. The objective of this study was to estimate the association between use of prostaglandins for labor induction in term singleton pregnancies complicated by delivery of small-for-gestational age (SGA) neonates and the risk of cesarean delivery for nonreassuring fetal status (NRFS). Read More

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http://dx.doi.org/10.1080/14767058.2019.1608177DOI Listing
April 2019
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Collective Total Synthesis of the Prostaglandins Family via Stereocontrolled Organocatalytic Baeyer-Villiger Oxidation.

Angew Chem Int Ed Engl 2019 Apr 14. Epub 2019 Apr 14.

CHINA.

A new protocol for the synthesis of prostaglandins using a stereocontrolled organocatalytic Baeyer-Villiger (B-V) oxidation was described for the first time. The key B-V oxidation of racemic cyclobutanone with aqueous hydrogen peroxide has enabled an early stage construction of bicyclic lactone skeleton in high enantiomeric excess (up to 99%). The generated bicyclic lactone is fully primed with two desired stereocenters and enabled the assembly of the entire family of prostaglandins. Read More

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http://dx.doi.org/10.1002/anie.201902371DOI Listing

Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells.

Prostaglandins Other Lipid Mediat 2019 Apr 9;142:59-67. Epub 2019 Apr 9.

Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden. Electronic address:

Relatively little is known about the endocannabinoid system in human neuroblastoma cell lines. In the present study, we have investigated the expression of the genes coding for the enzymes involved in the synthesis and catabolism of endocannabinoids in the SH-SY5Y cell line. The expression of MGLL, the gene coding for the 2-arachidonoylglycerol hydrolytic enzyme monoacylglycerol lipase (MAGL), was found to be 85 and 340 fold lower than the expression levels for the genes coding for alpha/beta-hydrolase domain containing 6 and 12 (ABHD6, ABHD12), which are alternative hydrolytic enzymes for this endocannabinoid. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.04.003DOI Listing
April 2019
2 Reads

HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism.

Mol Cancer Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University

Chronic hepatitis B viral (HBV) infection remains a high underlying cause for hepatocellular carcinoma (HCC) worldwide, while the genetic mechanisms behind this remain unclear. This study elucidated the mechanisms contributing to tumor development induced by the HBV X (HBx) gene of predominantly Asian genotype B HBV and its common HBx variants. To compare the potential tumorigenic effects of K130M/V131I (Mut) and wild-type (WT) HBx on HCC, the Sleeping Beauty (SB) transposon system was used to deliver HBx Mut and WT into the livers of fumarylacetoacetate hydrolase (Fah)-deficient mice and in the context of transformation related protein 53 (Trp53) deficiency. Read More

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1127DOI Listing
April 2019
1 Read

Fish oil protects the liver from parenteral nutrition-induced injury via GPR120-mediated PPARγ signaling.

Prostaglandins Leukot Essent Fatty Acids 2019 Apr 5;143:8-14. Epub 2019 Mar 5.

Vascular Biology Program and Department of Surgery, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, United States. Electronic address:

Intravenous fish oil lipid emulsions (FOLE) can prevent parenteral nutrition (PN)-induced liver injury in murine models and reverse PN-induced cholestasis in pediatric patients. However, the mechanisms by which fish oil protects the liver are incompletely characterized. Fish oil is rich in omega-3 fatty acids, which are ligands for the G-protein coupled receptor 120 (GPR120), expressed on hepatic Kupffer cells. Read More

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http://dx.doi.org/10.1016/j.plefa.2019.02.003DOI Listing
April 2019
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Combining a high DHA multi-nutrient supplement with aerobic exercise: Protocol for a randomised controlled study assessing mobility and cognitive function in older women.

Prostaglandins Leukot Essent Fatty Acids 2019 Apr 1;143:21-30. Epub 2019 Apr 1.

Department of Life Sciences, University of Roehampton, London, U.K. Electronic address:

There is a complex interplay between cognition and gait in older people, with declines in gait speed coexisting with, or preceding cognitive decline. Omega-3 fatty acids, B vitamins, vitamin E, phosphatidylserine, and Ginkgo Biloba show promise in preserving mobility and cognitive function in older adults. Exercise benefits mobility and there is evidence suggesting positive interactions between exercise and omega-3 fatty acids on physical and cognitive function in older adults. Read More

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http://dx.doi.org/10.1016/j.plefa.2019.04.001DOI Listing
April 2019
2 Reads

Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva.

Prostaglandins Leukot Essent Fatty Acids 2019 Apr 1;143:15-20. Epub 2019 Mar 1.

Pharmacology and Toxicology Laboratory, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India. Electronic address:

Over the past few years, there has been a tremendous increase in interest of general population toward food-based therapies for management of chronic clinical conditions due to their lesser adverse effects with prolonged use over pharmacotherapies. Foods enriched with omega-3 fatty acids have shown some promising results in case of epilepsy. The present study was envisioned to investigate the effect of early exposure of α-linolenic acid (ALA), an essential omega-3 fatty acid in developing zebrafish (Danio rerio) embryos toward pentylenetetrazol (PTZ)-induced seizure susceptibility. Read More

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http://dx.doi.org/10.1016/j.plefa.2019.02.002DOI Listing
April 2019
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Plasma phospholipid fatty acids are associated with altered fibrin clot properties in a population-based setting.

Prostaglandins Leukot Essent Fatty Acids 2019 Apr 7;143:1-7. Epub 2019 Feb 7.

Centre of Excellence for Nutrition, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:

Evidence regarding the relationship of plasma clot properties with fatty acids is contradictory, owing to different experimental protocols employed. The relationship of fibrinogen and plasma fibrin clot properties with plasma phospholipid fatty acids were cross-sectionally investigated in a population-based setting in 900 individuals. Composite saturated fatty acids (driven by stearic acid) and composite n-3 and n-6 polyunsaturated fatty acids (driven by docosahexaenoic and arachidonic acid respectively) were associated with prothrombotic clot properties. Read More

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http://dx.doi.org/10.1016/j.plefa.2019.02.001DOI Listing

AK106-001616, a potent and selective inhibitor of cytosolic phospholipase A2: in vivo efficacy for inflammation, neuropathic pain, and pulmonary fibrosis.

J Pharmacol Exp Ther 2019 Apr 10. Epub 2019 Apr 10.

Asahi Kasei Pharma Co. Ltd.

AK106-001616 is a novel, potent, and selective inhibitor of the cytosolic phospholipase A2 (cPLA2) enzyme. Unlike traditional non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors, AK106-001616 reduced prostaglandin (PG) E2 and leukotriene (LT) B4 production by stimulated cells. The suppression of PGE2 and LTB4 production was also confirmed using an air pouch model in rats administered a single oral dose of AK106-001616. Read More

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http://dx.doi.org/10.1124/jpet.118.255034DOI Listing
April 2019
3 Reads

Inhaled Iloprost Versus Epoprostenol in Heart Transplant Recipients.

Respir Care 2019 Apr 9. Epub 2019 Apr 9.

Department of Anesthesiology & Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon.

Background: Acute right ventricular dysfunction is a challenging problem in the immediate postoperative period following orthotopic heart transplantation. There are no prior reports of the use of inhaled iloprost in the setting of acute right ventricular dysfunction and acute pulmonary hypertension. Our hypothesis was that the use of inhaled iloprost in heart transplant recipients would be associated with a reduction in the duration of mechanical ventilation compared to patients being treated with continuous inhaled epoprostenol. Read More

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http://dx.doi.org/10.4187/respcare.06426DOI Listing
April 2019
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Understanding the pathobiology in patent ductus arteriosus in prematurity-beyond prostaglandins and oxygen.

Pediatr Res 2019 Apr 9. Epub 2019 Apr 9.

Radboud Institute for Health Sciences, Amalia Children's Hospital, Division of Neonatology, Department of Pediatrics, Radboud university medical center, Geert Grooteplein zuid 10, Postal code 804, 6525 GA, Nijmegen, The Netherlands.

The ductus arteriosus (DA) is probably the most intriguing vessel in postnatal hemodynamic transition. DA patency in utero is an active state, in which prostaglandin E (PGE) and nitric monoxide (NO), play an important role. Since the DA gets programmed for postnatal closure as gestation advances, in preterm infants the DA frequently remains patent (PDA). Read More

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http://www.nature.com/articles/s41390-019-0387-7
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http://dx.doi.org/10.1038/s41390-019-0387-7DOI Listing
April 2019
2 Reads

The Effect of Local Pharmacological Agents in Acceleration of Orthodontic Tooth Movement: A Systematic Review.

Open Access Maced J Med Sci 2019 Mar 14;7(5):882-886. Epub 2019 Mar 14.

Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Aim: Acceleration of orthodontic tooth movement has gained a massive interest to decrease the total treatment time. Local pharmacological agents might be used for that purpose as a practical, effective and inexpensive alternative. A systematic review was achieved to evaluate the evidence in that topic. Read More

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http://dx.doi.org/10.3889/oamjms.2019.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447353PMC

Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F-induced Contractions and Inflammatory Responses in Human Myometrium.

Sci Rep 2019 Apr 8;9(1):5792. Epub 2019 Apr 8.

Imperial College London, Parturition Research Group, IRDB, Du Cane Road, London, W12 0NN, UK.

Oxytocin receptor antagonists (OTR-A) have been developed as tocolytics for the management of preterm labour due to the significant role of oxytocin (OT) in the onset of both term and preterm labour. Similar to OT, prostaglandins (PGs) play key roles in myometrial contractility and cervical ripening. Inhibition of PG synthesis/activity is used to delay preterm birth. Read More

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http://www.nature.com/articles/s41598-019-42181-2
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http://dx.doi.org/10.1038/s41598-019-42181-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453954PMC
April 2019
4 Reads

Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer.

Prostaglandins Other Lipid Mediat 2019 Apr 5. Epub 2019 Apr 5.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Katraj-Dhankawadi, Pune-Satara Road, Pune, 411043, Maharashtra, India. Electronic address:

Cervical cancer is the second leading cause of cancer death in women in India. Previously, we have reported that alpha linolenic acid (ALA), induced apoptosis in cervical cancer cell lines and reduced expression of E6 and E7 oncoproteins with simultaneous decrease in Cox2/VEGF/MAP kinase proteins. Here, we investigated the tumor retardation potential of flax oil (FO), rich in ALA, in mouse papilloma model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10988823183010
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http://dx.doi.org/10.1016/j.prostaglandins.2019.04.002DOI Listing
April 2019
5 Reads

Evaluation of anti-inflammatory potential of the leaves of Wendlandia heynei (Schult.) Santapau & Merchant in Sprague Dawley rat.

J Ethnopharmacol 2019 Apr 4;238:111849. Epub 2019 Apr 4.

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:

Ethnopharmacological Relevance: The leaves of W. heynei (family: Rubiaceae) are used by the folklore in swelling, wounds and body aches. In this study anti-inflammatory potential of W. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111849DOI Listing
April 2019
1 Read

Regulation of nicotinic acetylcholine receptor α3 subtype in adipose tissue dysfunction.

Prostaglandins Other Lipid Mediat 2019 Apr 3;142:53-58. Epub 2019 Apr 3.

Ethnic Drug Screening & Pharmacology Center, Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650500, China. Electronic address:

Nicotinic acetylcholine receptor α3 subtype (α3-nAChR) plays a pivotal role in regulating inflammatory responses. Inflammation leads to the adipose tissue dysfunction and further increases the risk of metabolic and cardiovascular diseases. Therefore, we hypothesize that α3-nAChR could regulate the disorder of adipose functions. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.04.001DOI Listing
April 2019
1 Read

The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer.

Anticancer Res 2019 Apr;39(4):1719-1728

Cell and Experimental Pathology, Department of Translational Medicine, Clinical Research Centre, Lund University, Malmö, Sweden

Background: The wingless-type mammary tumour virus integration site 5A (WNT5A) agonist Foxy5 was shown in vitro to affect intracellular signalling implicated in the regulation of colonic cancer stem cells (CSCs).

Materials And Methods: In order to study whether Foxy5 can modulate CSCs, either HT-29 or Caco-2 human colonic cancer cells, both lacking endogenous WNT5A expression, were inoculated subcutaneously into nude mice.

Results: Foxy5 reduced the expression of the stem-cell marker aldehyde dehydrogenase and, interestingly, the specific colon CSC marker double cortin-like kinase 1. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13278DOI Listing
April 2019
1 Read

Microtubule depolymerization attenuates WNT4/CaMKIIα signaling in mouse uterus and leads to implantation failure.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

A Dwivedi, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.

Microtubule (MT) dynamics plays a crucial role in fertilization and early embryonic development but its involvement in uterus during embryo implantation remains unclear. Herein, we report the effect of microtubule depolymerization during embryo implantation in BALB/c mice. Intra-uterine treatment with depolymerizing agent nocodazole at pre-implantation phase (D4, 0700h) in mice resulted into mitigation in receptivity markers viz. Read More

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http://dx.doi.org/10.1530/REP-18-0611DOI Listing
April 2019
2 Reads

Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: suppression of SAPK/JNK and p38 MAP kinase.

Prostaglandins Other Lipid Mediat 2019 Apr 1. Epub 2019 Apr 1.

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. Electronic address:

Heat shock protein (HSP) 90 that is ubiquitously expressed in various tissues, is a major molecular chaperone. We have previously demonstrated that prostaglandin D (PGD), a bone remodeling factor, elicits the expression of HSP27, a small HSP, through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the involvement of HSP90 in the PGD-stimulated HSP27 induction and the underlying mechanism in MC3T3-E1 cells. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.03.002DOI Listing

Epigenetic regulation of progesterone receptors and the onset of labour.

Reprod Fertil Dev 2019 Apr 4. Epub 2019 Apr 4.

Progesterone plays a crucial role in maintaining pregnancy by promoting myometrial quiescence. The withdrawal of progesterone action signals the end of pregnancy and, in most mammalian species, this is achieved by a rapid fall in progesterone concentrations. However, in humans circulating progesterone concentrations remain high up to and during labour. Read More

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http://dx.doi.org/10.1071/RD18392DOI Listing
April 2019
1 Read

[Conservative treatment of chronic lower limb ischemia in ambulatory practice (in Russian only)].

Khirurgiia (Mosk) 2019 (3):98-104

Russian Medical Academy of Postgraduate Education, Moscow, Russia.

Peripheral artery disease is still one of the most important surgical problems. General surgeons treat the majority of patients with chronic lower limb ischemia due to the lack of specialized surgical care. Current methods for risk factors adjustment, exercise therapy and the most common drugs for intermittent claudication management are reviewed in the article. Read More

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http://dx.doi.org/10.17116/hirurgia201903198DOI Listing
January 2019
2 Reads

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration.

Nat Immunol 2019 05 1;20(5):626-636. Epub 2019 Apr 1.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Muscle damage elicits a sterile immune response that facilitates complete regeneration. Here, we used mass spectrometry-based lipidomics to map the mediator lipidome during the transition from inflammation to resolution and regeneration in skeletal muscle injury. We observed temporal regulation of glycerophospholipids and production of pro-inflammatory lipid mediators (for example, leukotrienes and prostaglandins) and specialized pro-resolving lipid mediators (for example, resolvins and lipoxins) that were modulated by ibuprofen. Read More

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http://dx.doi.org/10.1038/s41590-019-0356-7DOI Listing
May 2019
20.004 Impact Factor

Regulatory roles of PGE in LPS-induced tissue damage in bovine endometrial explants.

Eur J Pharmacol 2019 Jun 28;852:207-217. Epub 2019 Mar 28.

Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, 010018, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, 010018, Hohhot, China. Electronic address:

Bovine endometritis is the most common uterine disease following parturition. The role of prostaglandin E (PGE) in regulating normal physiological function in the bovine endometrium has been clearly established. Although PGE accumulation is observed in multiple inflammatory diseases, such as endometritis, its association with pathogen-induced inflammatory damage in the endometrium is unclear. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.044DOI Listing
June 2019
1 Read

Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase.

Prostaglandins Other Lipid Mediat 2019 Mar 28;142:24-32. Epub 2019 Mar 28.

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany. Electronic address:

5-lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes and specialized proresolving lipid mediators (SPM). It is mainly expressed in leukocytes and is part of the innate immune system. 5-LO can shuttle between the cytosol and the nucleus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10988823193001
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http://dx.doi.org/10.1016/j.prostaglandins.2019.03.003DOI Listing
March 2019
3 Reads

Prostaglandin-mediated effects in early canine corpus luteum: In vivo effects on vascular and immune factors.

Reprod Biol 2019 Mar 28;19(1):100-111. Epub 2019 Mar 28.

Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. Electronic address:

Prostaglandins (PGs) are important regulators of the early corpus luteum (CL) in the dog. Whereas, initially, CL is gonadotropin independent, in the second half of its lifespan, hypophyseal support is required. The transition period is marked by decreased availability of PGs, in particular of PGE2. Read More

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http://dx.doi.org/10.1016/j.repbio.2019.02.001DOI Listing

Neutral sphingomyelinase increases and delocalizes in the absence of Toll-Like Receptor 4: A new insight for MPTP neurotoxicity.

Prostaglandins Other Lipid Mediat 2019 Mar 27;142:46-52. Epub 2019 Mar 27.

Department of Pharmaceutical Science, University of Perugia, Italy. Electronic address:

Both sphingomyelinase and Toll-Like Receptor 4 (TLR4) are implicated in neurodegenerative diseases. However, the relationship between the two molecules remains unclear. In this study, using WT and TLR4-deficient mice, treated or not with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we aimed to investigate the relation between TLR4 and neutral sphingomyelinase (nSMase) in the midbrain. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.03.004DOI Listing
March 2019
2 Reads

Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract.

Prostaglandins Other Lipid Mediat 2019 Mar 28;142:33-45. Epub 2019 Mar 28.

Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland. Electronic address:

The objective of the present study was to determine the influence of dietary supplementation with pomegranate seed oil (PSO) and/or an aqueous extract of dried bitter melon fruits (BME) on breast cancer risk and fatty acid profile in serum of female rats with chemical carcinogen-inflicted mammary tumours. Sprague-Dawley rats (n = 96) were fed control diet or experimental diets supplemented with 0.15 ml PSO/day, BME or jointly PSO and BME. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.03.005DOI Listing

Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors.

Inflamm Res 2019 Mar 29. Epub 2019 Mar 29.

Department of Biochemistry and Molecular Biology, Faculty of Health Sciences, University of Bielsko-Biala, Willowa 2 Str., 43-309, Bielsko-Biała, Poland.

The peroxisome proliferator-activated receptor (PPAR) family includes three transcription factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised and nitrated fatty acid derivatives as well as by cyclopentenone prostaglandins (PGA and 15d-PGJ) during the inflammatory response. This results in the modulation of the pro-inflammatory response, preventing it from being excessively activated. Read More

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http://dx.doi.org/10.1007/s00011-019-01231-1DOI Listing
March 2019
1 Read

Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases.

Int Immunol 2019 Mar 29. Epub 2019 Mar 29.

Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan.

Prostaglandins (PGs) are the major lipid mediators in animals and which are biosynthesized from arachidonic acid by the cyclooxygenases (COX-1 or COX-2) as the rate-limiting enzymes. Prostaglandin E2 (PGE2), which is the most abundantly detected PG in various tissues, exerts versatile physiological and pathological actions via four receptor subtypes (EP1-4). Non-steroidal anti-inflammatory drugs, such as aspirin and indomethacin, exert potent anti-inflammatory actions by the inhibition of COX activity and the resulting suppression of PG production. Read More

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https://academic.oup.com/intimm/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/intimm/dxz021DOI Listing
March 2019
4 Reads

miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.

FASEB J 2019 Mar 28:fj201802547R. Epub 2019 Mar 28.

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.

MicroRNAs (miRs) are important posttranscriptional regulators of gene expression. Besides their well-characterized inhibitory effects on mRNA stability and translation, miRs can also activate gene expression. In this study, we identified a novel noncanonical function of miR-574-5p. Read More

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http://dx.doi.org/10.1096/fj.201802547RDOI Listing

Cellular and molecular mechanisms of the preovulatory follicle differenciation and ovulation: What do we know in the mare relative to other species.

Theriogenology 2019 May 19;130:163-176. Epub 2019 Mar 19.

PRC, INRA, CNRS, IFCE, Université de Tours, 37380, Nouzilly, France.

Terminal follicular differentiation and ovulation are essential steps of reproduction. They are induced by the increase in circulating LH, and lead to the expulsion from the ovary of oocytes ready to be fertilized. This review summarizes our current understanding of cellular and molecular pathways that control ovulation using a broad mammalian literature, with a specific focus to the mare, which is unique in some aspects of ovarian function in some cases. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.03.007DOI Listing
May 2019
4 Reads

15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection.

PLoS Pathog 2019 03 28;15(3):e1007597. Epub 2019 Mar 28.

Bateson Centre, Firth Court, University of Sheffield, Sheffield, South Yorkshire, United Kingdom.

Cryptococcus neoformans is one of the leading causes of invasive fungal infection in humans worldwide. C. neoformans uses macrophages as a proliferative niche to increase infective burden and avoid immune surveillance. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438442PMC

Influence of Anterior Biometry on Corneal Biomechanical Stiffness of Glaucomatous eyes Treated with Chronic Medication or Filtration Surgery.

J Glaucoma 2019 Mar 26. Epub 2019 Mar 26.

Imaging, Biomechanics, and Mathematical Modeling Solutions Lab, Narayana Nethralaya Foundation, Bangalore, India.

PRéCIS: Anterior chamber depth, IOP and thickness, confounded assessment of corneal biomechanical properties with non-contact applanation in glaucoma eyes. Compared to normal eyes, glaucoma eyes, which underwent long term treatment or filtration surgery, had similar properties.

Purpose: To evaluate corneal stiffness in primary angle closure (PACG) and primary open angle (POAG) glaucoma eyes sub-grouped based on type of topical medication and filtration surgery using non-contact applanation METHODS:: All eyes were retrospectively reviewed for intraocular pressure (IOP) with Corvis-ST (OCULUS Optikgerate Gmbh, Germany). Read More

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http://dx.doi.org/10.1097/IJG.0000000000001247DOI Listing
March 2019
2.427 Impact Factor

Remodeled structure and reduced contractile responsiveness of ocular ciliary artery in spontaneously hypertensive rats.

Int J Ophthalmol 2019 18;12(3):363-368. Epub 2019 Mar 18.

Department of Ophthalmology, Akita University School of Medicine, Akita 010-8543, Japan.

Aim: To investigate the alterations in both structure and contractile responsiveness of ocular ciliary artery (OCA) in spontaneously hypertensive rat (SHR).

Methods: In this experiment, 20-week-old male SHR and Wistar Kyoto rat (WKY) were studied. The heart rate (HR), the blood pressure (BP; the systolic BP and the diastolic BP) of rats with an electronic sphygmomanometer were measured. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2019.03.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423402PMC
March 2019
3 Reads

Pro-resolving lipid mediators as therapeutic leads for cardiovascular diseases.

Expert Opin Ther Targets 2019 Mar 27:1-14. Epub 2019 Mar 27.

b School of Chinese Medicine , The University of Hong Kong , Hong Kong , China.

Introduction: Cardiovascular diseases are the leading cause of human death globally. Lipid mediators contribute to the initiation and resolution of inflammation in the pathogenesis of cardiovascular diseases. These resolving lipid mediators antagonize the effects of pro-inflammatory prostaglandins (PGs) and leukotrienes (LTs) on macrophage/neutrophil infiltration, enhance macrophage phagocytosis towards apoptotic cells, and accelerate tissue repair. Read More

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http://dx.doi.org/10.1080/14728222.2019.1599360DOI Listing

A rare presentation of uterine rupture - the risk of sequential labour induction with prostaglandins and oxytocin.

J Obstet Gynaecol 2019 Mar 27:1-2. Epub 2019 Mar 27.

a Department of Obstetrics and Gynecology , Shaare Zedek Medical Center, Hebrew University Medical School of Jerusalem , Jerusalem , Israel.

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http://dx.doi.org/10.1080/01443615.2018.1553940DOI Listing

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death.

Sci Signal 2019 Mar 26;12(574). Epub 2019 Mar 26.

Department of Internal Medicine 3-Rheumatology and Immunology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU) 91054, Erlangen, Germany.

Enzymatically oxidized phospholipids (eoxPLs) are formed through regulated processes by which eicosanoids or prostaglandins are attached to phospholipids (PLs) in immune cells. These eoxPLs comprise structurally diverse families of biomolecules with potent bioactivities, and they have important immunoregulatory roles in both health and disease. The formation of oxPLs through enzymatic pathways and their signaling capabilities are emerging concepts. Read More

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http://dx.doi.org/10.1126/scisignal.aau2293DOI Listing

NF-κB targeting for overcoming tumor resistance and normal tissues toxicity.

J Cell Physiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Medical Physics, Tehran University of Medical Sciences (International Campus), Tehran, Iran.

Radiotherapy and chemotherapy are two famous modalities in tumor-targeted therapy that lead to systemic and local toxicities for normal tissues. Moreover, several studies have confirmed that exposure of the tumor to radiation or chemotherapy drugs stimulate some signaling pathways in the tumor microenvironment (TME), leading to resistance of cancer cells to apoptosis, as well as promoting angiogenesis and tumor growth. Nuclear factor kappa B (NF-κB) plays a central role in the regulation of inflammatory responses in both normal tissues and tumors via the release of several cytokines, regulation of prostaglandins, reduction/oxidation (redox) reactions, angiogenesis, and cell death. Read More

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http://dx.doi.org/10.1002/jcp.28504DOI Listing
March 2019
1 Read
3.839 Impact Factor

Hypoxia, cytokines and stromal recruitment: parallels between pathophysiology of encapsulating peritoneal sclerosis, endometriosis and peritoneal metastasis.

Pleura Peritoneum 2018 Mar 21;3(1):20180103. Epub 2018 Mar 21.

Upper GI Surgery Department, Liverpool Hospital, Elizabeth St, Liverpool, 2170, NSW, Australia.

Peritoneal response to various kinds of injury involves loss of peritoneal mesothelial cells (PMC), danger signalling, epithelial-mesenchymal transition and mesothelial-mesenchymal transition (MMT). Encapsulating peritoneal sclerosis (EPS), endometriosis (EM) and peritoneal metastasis (PM) are all characterized by hypoxia and formation of a vascularized connective tissue stroma mediated by vascular endothelial growth factor (VEGF). Transforming growth factor-β1 (TGF-β1) is constitutively expressed by the PMC and plays a major role in the maintenance of a transformed, inflammatory micro-environment in PM, but also in EPS and EM. Read More

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http://dx.doi.org/10.1515/pp-2018-0103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405013PMC
March 2018
2 Reads

Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model.

Eurasian J Med 2019 Feb;51(1):75-79

Department of Histology and Embriology, Ataturk University School of Medicine, Erzurum, Turkey.

Objective: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR.

Materials And Methods: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group. Read More

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http://www.eajm.org/eng/makale/3151/211/Full-Text
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http://dx.doi.org/10.5152/eurasianjmed.2019.19025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422614PMC
February 2019
6 Reads

Pathophysiology of iron overload-induced renal injury and dysfunction: Roles of renal oxidative stress and systemic inflammatory mediators.

Pathophysiology 2019 Mar 18. Epub 2019 Mar 18.

Applied and Environmental Physiology Unit, Department of Physiology, University of Ibadan, Nigeria.

Iron-overload has been recognized as a risk factor for organ dysfunction and damage resulting in diseases such as liver and heart disease, diabetes mellitus, and neurodegenerative diseases. This study investigated renal function and some systemic inflammatory indices in iron-overloaded male Wistar rats. Thirty animals were equally distributed into 3groups and treated daily i. Read More

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http://dx.doi.org/10.1016/j.pathophys.2019.03.002DOI Listing
March 2019
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The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.

Kidney Int 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Augusta University, Augusta, Georgia, USA; Vascular Biology Center, Augusta University, Augusta, Georgia, USA; Department of Pharmacology and Toxicology, Augusta University, Augusta, Georgia, USA. Electronic address:

In mice, the initial stage of nephrotoxic serum-induced nephritis (NTN) mimics antibody-mediated human glomerulonephritis. Local immune deposits generate tumor necrosis factor (TNF), which activates pro-inflammatory pathways in glomerular endothelial cells (GECs) and podocytes. Because TNF receptors mediate antibacterial defense, existing anti-TNF therapies can promote infection; however, we have previously demonstrated that different functional domains of TNF may have opposing effects. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.022DOI Listing
March 2019
1 Read
8.563 Impact Factor

Transcriptional Regulation of Thrombospondins and Its Functional Validation through CRISPR/Cas9 Mediated Gene Editing in Corpus Luteum of Water Buffalo (Bubalus Bubalis).

Cell Physiol Biochem 2019 ;52(3):532-552

Indian Veterinary Research Institute, Physiology & Climatology Division, Bareilly, India,

Background/aims: Thrombospondins (TSPs) are large multi-modular proteins, identified as natural angiogenesis inhibitors that exert their activity by binding to CD36 and CD47 receptors. The anti-angiogenic effect of TSPs in luteal regression of water buffalo has not been addressed. The present study characterized the expression pattern and localization of TSPs and their receptors in ovarian corpus luteum during different stages of development in buffalo. Read More

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https://www.cellphysiolbiochem.com/Articles/000038/
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http://dx.doi.org/10.33594/000000038DOI Listing
April 2019
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Antioxidant, Gastroprotective, Cytotoxic Activities and UHPLC PDA-Q Orbitrap Mass Spectrometry Identification of Metabolites in Decoction.

Molecules 2019 Mar 19;24(6). Epub 2019 Mar 19.

Instituto de Biotecnología-Instituto de Ciencias Básicas, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 (O), San Juan CP 5400, Argentina.

The decoction of the local plant is used as a digestive, gastroprotective, external cicatrizing agent and antiseptic in Argentine. A lyophilized decoction (BLD) from the aerial parts of this plant was evaluated regarding its anti-ulcer, antioxidant and cytotoxic activities and the bioactivities were supported by UHPLC-MS metabolome fingerprinting which revealed the presence of several small bioactive compounds. The antioxidant properties were evaluated by DPPH, TEAC, FRAP and lipoperoxidation inhibition in erythrocytes methods, and the antibacterial activity was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Read More

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http://dx.doi.org/10.3390/molecules24061085DOI Listing
March 2019
1 Read