111,933 results match your criteria Prostaglandins & Other Lipid Mediators[Journal]
J Mol Med (Berl) 2018 Dec 7. Epub 2018 Dec 7.
Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Sinusoidal obstruction syndrome (SOS) is a major complication after hematopoietic stem cell transplantation and belongs to a group of diseases increasingly identified as transplant-related systemic endothelial disease. Administration of defibrotide affords some protection against SOS, but the effect is modest. Hence, there is unmet medical need justifying the preclinical search for alternative approaches. Read More
Theriogenology 2018 Dec 3;126:63-67. Epub 2018 Dec 3.
Laboratorio de Reproducción de Rumiantes Menores, INTA Bariloche, San Carlos de Bariloche, Argentina.
Different therapeutic strategies have been used with the objective of improve luteal function to reduce embryonic losses. The objective of this work was to study the effect of the administration of GnRH or hCG at Day 4 post fixed time artificial insemination (FTAI) on reproductive efficiency in Merino sheep during the breeding season in North Patagonia. Estrus of multiparous Merino ewes (n = 288) was synchronized by two injections of prostaglandins (PG; 125 μg, Cloprostenol), 14 days apart. Read More
Prostaglandins Other Lipid Mediat 2018 Dec 4;140:18-25. Epub 2018 Dec 4.
Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, United States. Electronic address:
Vasoactive intestinal peptide (VIP) has been shown to regulate corneal inflammation. Formyl peptide receptor 2 (FPR2) is a transmembrane protein belonging to the GPCR family. Ligands include pro-resolving lipids, lipoxin A4 (LXA4) and resolvin D1 (RvD1). Read More
J Cataract Refract Surg 2018 Dec 5. Epub 2018 Dec 5.
From the Cornea and Refractive Surgery Group (Liu, Setiawan, Ang, Yam, Mehta), Eye Research Institute, the Singapore National Eye Centre (Liu, Ang, Mehta), and the Duke-NUS Medical School (Liu, Yam, Mehta), Singapore. Electronic address:
Purpose: To compare the aqueous oxidative stress, prostaglandin E (PGE), and cytokine levels after low-energy femtosecond laser-assisted cataract surgery versus conventional phacoemulsification, and to evaluate the effect of a nonsteroidal antiinflammatory drug (NSAID) on the aqueous profiles.
Setting: Singapore National Eye Center, Singapore.
Design: Randomized controlled trial. Read More
JBRA Assist Reprod 2018 Dec 6. Epub 2018 Dec 6.
Nursing Research Center, Golestan University of Medical Sciences, Gorgan, IR Iran.
Objectives: Primary dysmenorrhea is a painful uterine contraction caused by endometrial laceration. Drug therapies and complementary medicine have been used to treat dysmenorrhea. The aim of this study was to investigate and offer an updated perspective on the treatments for dysmenorrhea. Read More
Physiol Behav 2018 Nov 30;199:366-374. Epub 2018 Nov 30.
Department of Psychology, Wright State University, Dayton, OH 45435, USA.
Disruption of attachment relations in early life is linked to greater vulnerability to depressive illness at later ages. Evidence suggests this process involves stress-induced activation of central inflammatory factors, though the specific mediators and processes involved are not known. We used a guinea pig model in which effects of maternal separation appear more clearly due to absence of the attachment figure than is the case for other laboratory rodents. Read More
World J Otorhinolaryngol Head Neck Surg 2018 Sep 5;4(3):162-168. Epub 2018 Sep 5.
Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, USA.
It is well-established that following ingestion of aspirin or any other inhibitor of cyclooxygenase-1, patients with Samter's disease, or aspirin-exacerbated respiratory disease (AERD) develop the sudden onset of worsening respiratory clinical symptoms, which usually involves nasal congestion, rhinorrhea, wheezing and bronchospasm. Gastrointestinal distress, nausea, a pruritic rash and angioedema can also occasionally develop. However, the underlying pathologic mechanism that drives these clinical reactions remains elusive. Read More
Saudi J Biol Sci 2018 Nov 9;25(7):1468-1472. Epub 2017 May 9.
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
The aim of the present study was to investigate the effect of resveratrol on acute pharyngitis in the mice models induced by xylene and carrageenan treatment. The mice treated with various doses of resveratrol (5, 10, 15, 20 and 30 mg/kg) showed inhibition of edema in a dose dependent manner. The edema formation was reduced by 67% in the mice treated with 20 mg/kg of resveratrol compared to those in the control group. Read More
Oman J Ophthalmol 2018 Sep-Dec;11(3):195-199
Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.
Glaucoma is a chronic, progressive disease of the optic nerve which is relatively uncommon in childbearing age; however, its management is a real challenge. Although the intraocular pressure decreases in pregnancy, many glaucoma patients continue to require treatment. In addition to the side effects, antiglaucoma medications on the mother, the possible side effects of drugs on the fetus must be taken into account. Read More
Auton Neurosci 2018 Nov 11. Epub 2018 Nov 11.
Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, QRO 76230, México. Electronic address:
Neuroinflammation is produced by local or systemic alterations and mediated mainly by glia, affecting the activity of various neural circuits including those involved in breathing rhythm generation and control. Several pathological conditions, such as sudden infant death syndrome, obstructive sleep apnea and asthma exert an inflammatory influence on breathing-related circuits. Consequently breathing (both resting and ventilatory responses to physiological challenges), is affected; e. Read More
Int J Alzheimers Dis 2018 1;2018:3128758. Epub 2018 Nov 1.
Instituto Maimónides de Investigación Biomédica (IMIBIC), Córdoba, Spain.
Alzheimer's disease (AD) represents the most common cause of dementia in the elderly. AD is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although the aetiology of AD is not clear, both environmental factors and heritable predisposition may contribute to disease occurrence. Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Nov 23. Epub 2018 Nov 23.
Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Center for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Cardiovascular and Metabolomics Research Center, Hualien Tzu Chi Hospital, Taiwan; Department of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan. Electronic address:
We previously discovered that palmitic acid methyl ester (PAME) is a potent vasodilator first identified and released from the superior cervical ganglion and remain understudied. Thus, we investigated PAME's role in modulating cerebral blood flow (CBF) and neuroprotection after 6 min of cardiac arrest (model of global cerebral ischemia). Our results suggest that PAME can enhance CBF under normal physiological conditions, while administration of PAME (0. Read More
Cell Mol Biol (Noisy-le-grand) 2018 Nov 30;64(14):96-100. Epub 2018 Nov 30.
Department of Molecular Medicine, Institute of Aziz Sancar Experimental Medicine Research, Istanbul University, Istanbul, Turkey.
Oral squamous cell carcinoma (OSCC) is a common type of cancer that genetic and environmental factors also lifestyle habits, infections play important roles in the pathogenesis of disease. Cyclooxygenase 2 (COX2) is the inducible isoform of enzyme which convert arachidonic acid to prostaglandins. It was known that alterations in COX2 gene functions contribute to the inflammation process thus induce cancer progression, including cell proliferation, apoptosis, adhesion, invasion and metastasis. Read More
Endocr Rev 2018 Nov 28. Epub 2018 Nov 28.
Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY.
The midcycle surge of luteinizing hormone (LH) sets in motion interconnected networks of signaling cascades to bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators of these LH-induced signaling cascades are associated with inflammation, leading to the postulate that ovulation is similar to an inflammatory response. First responders to the LH surge are granulosa and theca cells, which produce steroids, prostaglandins, chemokines, and cytokines, which are also mediators of inflammatory processes. Read More
Toxicol Mech Methods 2018 Nov 29:1-40. Epub 2018 Nov 29.
a Department of Biophysics , Panjab University , Chandiigarh - 160014 , India.
Ulcerative colitis (UC), a form of inflammatory bowel disease (IBD), is an immune-modulated disorder characterized by chronic and recurring inflammatory episodes. Oxidative stress and COX pathway of prostaglandin (PG) biosynthesis is indispensable to pathogenesis of UC. Any imbalance between PGs can compromise the mucosal homeostasis, leading to mucosal damage and chronic inflammation. Read More
J Cancer Res Ther 2018 Oct-Dec;14(6):1366-1372
Department of Radiation Oncology, Army Hospital (R & R), New Delhi, India.
Context: Increased levels of prostaglandins have been detected in cancers of several anatomic sites, including those of endometrium. Several studies have shown that cyclooxygenase-2 (COX-2) expression is aberrantly increased in various human epithelial cancers, and cellular up-regulation of COX-2 may be a common mechanism in epithelial carcinogenesis.
Aims: To examine the expressions of COX-2, p53 and vascular endothelial growth factor (VEGF) in endometrial cancer and their relationships with clinicopathologic characteristics. Read More
Expert Opin Ther Targets 2019 Jan 2;23(1):1-13. Epub 2018 Dec 2.
a Department of Pharmacology , Emory University School of Medicine , Atlanta , GA , USA.
Introduction：A robust neuroinflammatory response is a prevalent feature of multiple neurological disorders, including epilepsy and acute status epilepticus. One component of this neuroinflammatory reaction is the induction of cyclooxygenase-2 (COX-2), synthesis of several prostaglandins and endocannabinoid metabolites, and subsequent activation of prostaglandin and related receptors. Neuroinflammation mediated by COX-2 and its downstream effectors has received considerable attention as a potential target class to ameliorate the deleterious consequences of neurological injury. Read More
J Lipid Res 2018 Nov 27. Epub 2018 Nov 27.
Vanderbilt University, United States
Lysophospholipids (LysoPL) are bioactive lipid species involved in cellular signaling processes and the regulation of cell membrane structure. LysoPLs are metabolized through the action of lysophospholipases, including lysophospholipase A1 (LYPLA1) and lysophospholipase A2 (LYPLA2). A new X-ray crystal structure of LYPLA2 compared to a previously published structure of LYPLA1 demonstrated near identical folding of the two enzymes; however, LYPLA1 and LYPLA2 have displayed distinct substrate specificities in recombinant enzyme assays. Read More
J Chromatogr A 2018 Nov 22. Epub 2018 Nov 22.
CQM - Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9020-105 Funchal, Portugal; Faculdade de Ciências Exatas e da Engenharia, Universidade da Madeira, Campus Universitário da Penteada, 9020-105, Funchal, Portugal. Electronic address:
Leukotrienes and prostaglandins are arachidonic acid bioactive derived eicosanoids and key mediators of bronchial inflammation and response modulation in the airways contributing to the pathophysiology of asthma. An easy-to-use ultra-high pressure liquid chromatography (UHPLC)-based strategy was developed to characterize biomarkers of lipid peroxidation: leukotrienes E (LTE) and B (LTB) and 11β-prostaglandin F (11βPGF), present in urine of asthmatic patients (N = 27) and healthy individuals (N = 17). A semi-automatic eVol®-microextraction by packed sorbent (MEPS) was used to isolate the target analytes. Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Dec 2;139:9-13. Epub 2018 Nov 2.
Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan. Electronic address:
In contrast to the cumulative evidence suggesting the inverse association of n-3 polyunsaturated fatty acids (PUFAs) with depression, few studies have examined the association of n-6 PUFAs with depression. In particular, no study has examined the relationship between n-6 PUFAs and depression in cancer patients. Thus, we conducted this cross-sectional study to comprehensively examine the association of n-3 and n-6 PUFAs with depressive symptoms in breast cancer survivors. Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Dec 8;139:31-39. Epub 2018 Nov 8.
Medical School, Royal Perth Hospital Unit, University of Western Australia, Box X2214 GPO Perth, Western Australia 6847, Australia; Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Australia.
Introduction: The synthetic glucocorticoid dexamethasone is a commonly administered antiemetic. It has immunosuppressive effects and may alter postoperative blood glucose concentrations. Dexamethasone can effect key enzymes involved in inflammation resolution that is an active process driven by specialised lipid mediators of inflammation resolution (SPM). Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Dec 31;139:3-8. Epub 2018 Aug 31.
School of Agriculture, Food & Wine, University of Adelaide, Waite Campus, Urrbrae, SA 5064, Australia; Healthy Mothers, Babies and Children theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA 5000, Australia. Electronic address:
Long chain polyunsaturated fatty acid (LCPUFA) intake during infancy has been associated with many health benefits, and the LCPUFA intake of breastfed infants is largely dependent on the composition of breast milk. The conventional method for breast milk fatty acid profiling is complicated by the need for cold-chain transportation and storage, and the newly developed dried milk spot (DMS) technology overcomes these difficulties. This study aimed to determine the accuracy, sensitivity and applicability of the DMS method developed based on the PUFAcoat™ technology. Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Dec 9;139:25-30. Epub 2018 Nov 9.
Laboraroty of Nutrition and Neurological Sciences, Human Nutrition Area, Institute of Nutrition and Food Technology Dr. Fernando Monckeberg Barros (INTA), University of Chile, Santiago, Chile. Electronic address:
The aim of this study was to quantitate the relative impact of DHA and AA levels in erythrocytes, anthropometric parameters and socio-economic status of school-age children, of both genders, graduated from high school in Chile, on the scholastic achievement in the University Selection Test (Prueba de Selección Universitaria, PSU) both language scholastic achievement (LSA) and mathematics scholastic achievement (MSA). A representative sample of 671 school-age young graduated from high school in 2013, 550 and 548 of them took the PSU for LSA and MSA, respectively. Only school-age young with high (n = 91) and low (n = 69) SA in both tests were considered. Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Dec 9;139:20-24. Epub 2018 Nov 9.
Department of Preventive Cardiology, Medizinische Klinik I, Ludwig Maximilians-University, Munich, Germany; Omegametrix, Martinsried, Germany.
Background: Several studies have suggested that low levels of omega-3 fatty acids (n-3 PUFAs) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with cardiovascular risk, major depression, sleep problems, inflammation and other health-related issues. So far, however, erythrocyte PUFA status in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) has not been established. This study aimed to determine whether n-3 PUFA content and omega-3 index are associated with measures in CFS/ME patients. Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Dec 2;139:14-19. Epub 2018 Nov 2.
Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI; Department of Family Medicine, University of Michigan, Ann Arbor, MI. Electronic address:
This study evaluated whether mRNA expression of major genes regulating formation of prostaglandin (PG)E in the colon and colonic fatty acid concentrations are associated with the reduction in colonic mucosal PGE after dietary supplementation with omega-3 (ω-3) fatty acids. Supplementation with ω-3 fatty acids was done for 12 weeks using personalized dosing that was expected to reduce colonic PGE by 50%. In stepwise linear regression models, the ω-3 fatty acid dose and baseline BMI explained 16. Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Dec 20;139:1-2. Epub 2018 Oct 20.
Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, and OmegaQuant, LLC, Sioux Falls, SD, USA.
Congenit Heart Dis 2018 Nov 23. Epub 2018 Nov 23.
Mildred T. Stahlman Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.
Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left-to-right shunt through the patent ductus arteriosus, a condition associated with significant morbidities. Numerous factors contribute to the shift from fetal ductus patency to postnatal closure, requiring precise coordination of molecular cues with biomechanical forces and underlying genetic influences. Read More
Phytomedicine 2018 Dec 19;51:7-19. Epub 2018 May 19.
Laboratório de Eletrofisiologia e Farmacologia Cardiovascular, Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Rodovia Dourados-Itahum, km 12, P.O. Box 533, 79.804-970, Dourados, MS, Brazil. Electronic address:
Background: One of the medicinal plants widely used by the population in the treatment of hypertension, atherosclerosis and circulatory disorders is Cuphea carthagenensis (Jacq.) J.F. Read More
Nutrients 2018 Nov 20;10(11). Epub 2018 Nov 20.
Department of Pharmacy, University of Naples Federico II. Via Montesano 49, 80149 Naples, Italy.
Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. Even months after the end of chemotherapy, many cancer patients complain of hair loss, a condition that is psychologically difficult to manage. CIA disturbs social and sexual interactions and causes anxiety and depression. Read More
Front Pharmacol 2018 6;9:1157. Epub 2018 Nov 6.
Department of Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory mediators, including prostaglandins, cytokines, and chemokines. IL-1α is constitutively present in endothelial and epithelial cells, whereas IL-1β is inducible in myeloid cells and released following cleavage by caspase-1. Over the past 30 years, IL-1-mediated inflammation has been established in a broad spectrum of diseases, ranging from rare autoinflammatory diseases to common conditions such as gout and rheumatoid arthritis (RA), type 2 diabetes, atherosclerosis, and acute myocardial infarction. Read More
Vet Immunol Immunopathol 2018 Nov 25;205:65-71. Epub 2018 Oct 25.
Animal Reproduction Division, ICAR - Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243 122, India.
Inflammatory markers of endometrial origin are valuable in order to differentiate the pyometra from cystic endometrial hyperplasia in the bitch. In the present study, we hypothesized that histological categorization would distinguish the differential regulation of the proinflammatory genes in the endometrium of bitches with pyometra. Ovariohysterectomy was done on bitches with confirmatory diagnosis of pyometra (n = 18). Read More
Handb Clin Neurol 2018 ;156:193-209
Department of Human Physiology, University of Oregon, Eugene, OR, United States. Electronic address:
Human skin is the interface between the human body and the environment. As such, human temperature regulation relies largely on cutaneous vasomotor and sudomotor adjustments to appropriately thermoregulate. In particular, changes in skin blood flow can increase or decrease the convective heat transfer from internal tissues to the periphery where it can increase or prevent heat loss to the environment. Read More
Handb Clin Neurol 2018 ;156:129-133
Departments of Molecular Medicine and of Neuroscience, Dorris Neuroscience Center, Scripps Research Institute, La Jolla, CA, United States. Electronic address:
Classic lesion and physiology experiments identified the hypothalamic preoptic area as a pivotal region in the regulation of temperature homeostasis. The preoptic area can sense changes in local temperature, receives information about ambient temperature, contributes to fever, and can affect thermoregulation in response to several biologic signals. Electrophysiologic studies indicate that these actions are mediated by a neuronal circuitry that comprises temperature-sensitive as well as temperature-insensitive neurons. Read More
Prostaglandins Other Lipid Mediat 2018 Nov 16;140:1-8. Epub 2018 Nov 16.
College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Hunan, 410208, China. Electronic address:
Restenosis is a major problem after percutaneous coronary intervention (PCI) treatment. Inflammation is one of the major core mechanisms involved in the occurrence of restenosis, and plays an important role in intimal hyperplasia. Detoxification and activating blood circulation decoction (DABCD) is a traditional Chinese medicine that is used in the treatment and prevention of atherosclerotic and inflammatory diseases. Read More
Allergy 2018 Nov 17. Epub 2018 Nov 17.
Department of Internal Medicine, Jagiellonian University School of Medicine, Cracow, Poland.
Background: A special regulatory role for prostaglandin E (PGE ) has been postulated in nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD).
Objective: To investigate the effect of systemic aspirin (acetylsalicylic acid) administration on airway PGE biosynthesis in induced sputum supernatant (ISS) among subjects with NERD or aspirin-tolerant asthma with chronic rhinosinusitis with nasal polyposis (ATA-CRSwNP), as well as healthy controls (HC).
Methods: Induced sputum (IS) was collected from patients with NERD (n = 26), ATA-CRSwNP (n = 17), and HC (n = 21) at baseline and after aspirin challenge. Read More
J Pharmacol Exp Ther 2018 Nov 15. Epub 2018 Nov 15.
University of Szeged, Hungary
Vitamin E and their analogues as antioxidant and lipid soluble compounds can have diverse effects on the physiological processes. By binding to receptors and enzymes, they may modify the action of drugs. It has been proved that alpha-tocopherol succinate modifies the effects of β2 agonist terbutaline and cyclooxygenase (COX) inhibitors on rat trachea and myometrium. Read More
Life Sci 2018 Dec 12;215:198-206. Epub 2018 Nov 12.
Department of Biology, Faculty of Arts & Sciences, American University of Beirut, Beirut, Lebanon. Electronic address:
Aims: Sphingosine-1-phosphate (S1P) has been implicated lately in inflammatory bowel disease which has diarrhea as one of its symptoms. Diarrhea is due to altered water movements as a result of altered electrolyte transport, and in particular sodium. Sodium movements are geared by the sodium gradient established by the Na/K ATPase. Read More
J Cell Physiol 2018 Nov 15. Epub 2018 Nov 15.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Prostaglandins (PGs) belong to the group lipid mediators and can act as local hormones. They contain 20 carbon atoms, including a 5-carbon ring, and are biosynthesized from membrane phospholipid derived arachidonic acid through the arachidonate cyclooxygenase (COX) pathway with the help of various terminal synthase enzymes. Prostacyclin (prostaglandin I ) is one of the major prostanoids produced with the help of prostacyclin synthase (prostaglandin I synthase) enzyme and rapidly hydrolyzed into 6-keto-PGF in biological fluids. Read More
Front Microbiol 2018 31;9:2447. Epub 2018 Oct 31.
Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL, United States.
Eicosanoids are cellular metabolites, which shape the immune response, including inflammatory processes in macrophages. The effects of these lipid mediators on inflammation and bacterial pathogenesis are not clearly understood. Certain eicosanoids are suspected to act as molecular sensors for the recruitment of neutrophils, while others regulate bacterial uptake. Read More
Mini Rev Med Chem 2018 Nov 13. Epub 2018 Nov 13.
Department of Pharmaceutics, Qingdao University of Science and Technology, Qingdao 266042. China.
As important marine biological resources, corals produce a large amount of active organic compounds in their secondary metabolic processes, including numerous brominated, chlorinated, and iodinated compounds. These compounds, with novel structures and unique activities, guide the discovery and research of important lead compounds and novel biological mechanisms. Through large numbers of literature survey, this paper summarized a total of 145 halogenated secondary metabolites which were roughly divided into four major classes of terpenes, prostaglandins, steroids and alkaloids. Read More
Front Immunol 2018 29;9:2455. Epub 2018 Oct 29.
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, United States.
In 2009, the H1N1 swine flu pandemic highlighted the vulnerability of pregnant women to influenza viral infection. Pregnant women infected with influenza A virus were at increased risk of hospitalization and severe acute respiratory distress syndrome (ARDS), which is associated with high mortality, while their newborns had an increased risk of pre-term birth or low birth weight. Pregnant women have a unique immunological profile modulated by the sex hormones required to maintain pregnancy, namely progesterone and estrogens. Read More
J Pharmacol Exp Ther 2018 Nov 12. Epub 2018 Nov 12.
Prostaglandin transporter Oatp2a1/ is expressed at the apical (AP) membranes of type-1 alveolar epithelial (AT1) cells. To investigate the role of OATP2A1 in PGE handling by alveolar epithelium, we studied PGE transport across and secretion from monolayers of rat AT1-like (AT1-L) cells obtained by trans-differentiation of type-2 alveolar epithelial cells (AT2) isolated from male Wistar rats. Rat AT1-L cells expressed Oatp2a1/, together with smaller amounts of Mrp4/ and Oct1/ PGE uptake was saturable with Km 43. Read More
Prostaglandins Other Lipid Mediat 2018 Nov 6;140:9-17. Epub 2018 Nov 6.
Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China; Jiangxi Province Key Laboratory of Tumor Etiology and Molecular Pathology, Nanchang 330006, China. Electronic address:
Background: The renin angiotensin-aldosterone system (RAAS) and lipoxins (LXs) have similar roles in many processes. We previously reported that BML-111, a Lipoxin receptor agonist, inhibited chronic injury hepatic fibrosis by regulating RAAS, but whether LXs are involved in BML-111-mediated protection from acute injury is unclear still.
Methods: We established models of acute liver/lung injury and confirmed them with histopathology and myeloperoxidase (MPO) measurements. Read More
Mol Reprod Dev 2018 Nov 8. Epub 2018 Nov 8.
College of Life Sciences and Food Engineering, Hebei University of Engineering, Handan, China.
Lymph nodes are distributed all over the body and are part of the lymphatic system. The interferon-stimulated gene 15 kDa protein (ISG15) and prostaglandins (PGs) are involved in the establishment of pregnancy and are expressed in the uterus during early pregnancy in sheep. In this study, the ovine lymph nodes were obtained on Day 16 of the estrous cycle, and Days 13, 16, and 25 of pregnancy, and the expression of ISG15 and PG synthases, including cyclooxygenase 1 (COX-1), COX-2, prostaglandin E (PGE) synthase (PTGES), and a PGF synthase (aldo-keto reductase family 1, member B1, AKR1B1) were detected by quantitative real-time polymerase chain reaction, western blot analysis, and immunohistochemistry analysis. Read More
J Toxicol Sci 2018 ;43(11):671-684
Physiology Department, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, Mexico.
Thalidomide was originally developed to treat primary neurological and psychiatric diseases. There are reports of anticonvulsant effects of thalidomide in rats and antiepileptic effects in patients. Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine. Read More
Pathol Oncol Res 2018 Nov 6. Epub 2018 Nov 6.
Urology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
The initiation of prostatic malignancy has been linked to chronic inflammation. Stem cell factor (SCF) is an inflammatory cytokine that is specific to the c-KIT receptor which is type III receptor tyrosine kinase (RTK). Cyclooxygenases (COXs) are the main enzymes which are responsible for prostaglandins production from arachidonic acid. Read More
Molecules 2018 Nov 2;23(11). Epub 2018 Nov 2.
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation. Therefore, the development of probes for imaging COX-2 with positron emission tomography (PET) has gained interest because they could be useful for the study of inflammation in vivo, and for aiding anti-inflammatory drug development targeting COX-2. Read More
Nutrients 2018 Nov 2;10(11). Epub 2018 Nov 2.
Cellular and Molecular Medicine Department, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H8L1, Canada.
This review offers a systematic understanding about how polyphenols target multiple inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear understanding of the molecular mechanisms of action of phenolic compounds. Polyphenols regulate immunity by interfering with immune cell regulation, proinflammatory cytokines' synthesis, and gene expression. Read More
Inflamm Regen 2018 29;38:29. Epub 2018 Oct 29.
Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan.
Although 12()-hydroxyheptadecatrienoic acid (12-HHT) is an abundant fatty acid, it is long considered a byproduct of thromboxane A production. We identified a leukotriene B receptor 2 (BLT2)-specific agonistic activity in lipid extracts from rat small intestine, and mass spectrometric analysis of partially purified lipids containing BLT2 agonistic activity revealed that 12-HHT is an endogenous ligand of BLT2. In a dextran sulfate sodium (DSS)-induced inflammatory colitis model, BLT2-deficient mice exhibited enhanced intestinal inflammation, possibly due to impaired epithelial barrier function. Read More
PLoS One 2018 5;13(11):e0201561. Epub 2018 Nov 5.
Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Spondias mombin L. (yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp is rich in antioxidant compounds. This study aimed to investigate the gastroprotective and ulcer healing activities of yellow mombin juice (YMJ) in Wistar rats, and to elucidate the possible involved mechanisms. Read More