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Int J Mol Sci 2022 May 21;23(10). Epub 2022 May 21.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.

Bacterial extracellular vesicles (EVs) perform various biological functions, including those that are critical to microbes. Determination of EVs composition allows for a deep understanding of their role in the bacterial community and communication among them. , formerly , are commensal bacteria responsible for various infections, e. Read More

Antibiotics (Basel) 2022 May 16;11(5). Epub 2022 May 16.

Meda Pharma S.P.A., A Viatris Company, 20900 Monza, Italy.

(, formerly known as ) is the major causative agent of prosthetic joint infections (PJI). Treatment of PJI with antibiotics is difficult due to antibiotic resistance and adverse side effects on patients' health. Proper disinfection of the surgical site using a variety of povidone iodine formulations could prevent infection. Read More

Anaerobe 2022 May 20;76:102580. Epub 2022 May 20.

School of Dentistry, Cardiff University, Heath Park Campus, Cardiff, CF14 4XY, UK; Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Museum Place, Cardiff, CF10 3BG, United Kingdom; School of Veterinary Medicine, University of Surrey, Daphne Jackson Road, Guildford, GU2 7AL, United Kingdom. Electronic address:

Cutibacterium acnes (formally Propionibacterium acnes) is frequently identified within surgical device related infections. It is often co-isolated from infection sites with other opportunistic pathogens. Recent studies have demonstrated that C. Read More

Bioengineered 2022 05;13(5):12446-12461

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

The aims of this study were to investigate the outcomes of low- and high-virulence bacterial cervical intervertebral discs (IVDs) infection and its association with cervical IVDs degeneration in rats. A total of 75 clean grade male rats were used to establish the corresponding animal models of low and high virulent bacterial cervical disc infection via an anterior cervical approach, with injection of Propionibacterium acnes (P. acnes) and Staphylococcus epidermidis (S. Read More

J Hand Surg Glob Online 2021 Sep 31;3(5):306-310. Epub 2021 Jul 31.

Department of Orthopedic Surgery, CareMount Medical, Mount Kisco, NY.

() is a gram-positive, anaerobic, commensal organism found on nonglabrous skin, including the face, scalp, chest, and axilla. Recently, is one of the more frequently recognized organisms causing postoperative infections in implant surgery of the shoulder, second to only (), yet it is a rare postoperative complication of the wrist and hand. Multiple factors, including slow growth, multiorganism involvement, and selective growth media, complicate attributing a primary infection to . Read More

BMJ Case Rep 2022 Apr 12;15(4). Epub 2022 Apr 12.

Internal Medicine, Infectious Diseases, Boston University School of Medicine, Harvard Medical School, and VA Boston Healthcare System, West Roxbury, Massachusetts, USA.

We describe a case of a man in his 70s who presented with tachycardia and several weeks of right lower quadrant pain 3 months after partial right hepatectomy for hepatocellular carcinoma. Initial laboratory findings were significant for elevated C reactive protein and normal white cell count. CT revealed right pleural effusion and 5. Read More

BMC Infect Dis 2022 Apr 11;22(1):367. Epub 2022 Apr 11.

Department of Infectious Diseases, Kobe University Hospital, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan.

Background: Cutibacterium modestum was named in 2020. C. modestum was previously called Propionibacterium humerusii. Read More

J Clin Neurosci 2022 Jun 4;100:33-36. Epub 2022 Apr 4.

Department of Neurosurgery, Flinders Medical Centre, Adelaide, South Australia, Australia.

Background: Cutibacterium acnes, formerly known as Propionibacterium acnes, is increasingly recognized as a cause of surgical site infection and implant failure despite the use of prophylactic antibiotics and antiseptic surgical preparations. The aim of this study was to investigate whether C. acnes persists in the dermal layer of the skin after standard perioperative antibiotics and skin prepping with alcoholic betadine solution in consecutive patients undergoing a craniotomy. Read More

J Orthop 2022 May-Jun;31:40-44. Epub 2022 Mar 18.

Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Introduction: Posterior lumbar interbody fusion (PLIF) has been widely used to treat various degenerative spinal diseases. However, surgical site infection (SSI) post-PLIF is often difficult to cure. This study aimed to clarify the difference in clinical course due to the causative organism and develop a treatment strategy for SSI post-PLIF. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Mar 31. Epub 2022 Mar 31.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD, 21287, USA.

Purpose: Increased ophthalmology-specific risk of novel coronavirus 2019 (SARS-CoV-2) transmission is well-established, increasing the fear of infection and causing associated decreased rates of procedures known to save vision. However, the potential transmission from exposure to clinic instrumentation is unknown, including which additional pathogens may be spreading in this context. This study seeks to fill this gap by characterizing the microbiota of instrumentation in ophthalmology clinics during the COVID-19 pandemic and identifying potential sources of pathogenic spread encountered by patients and healthcare workers. Read More

Arch Ital Urol Androl 2022 Mar 29;94(1):62-64. Epub 2022 Mar 29.

Specialist Urology and Andrology Clinic, Salerno.

Objective: Propionibacterium acnes has been implicated in the pathogenesis of prostate disease as acute and chronic prostatic inflammation, benign prostatic hyperplasia and prostate cancer although it should still be clarified if Propionibacterium acnes (P. acnes) is a commensal or accidental prostate pathogen. Aiming to evaluate the pathogenic potential for genitourinary tract of Propionibacterium acnes, we investigated the frequency of P. Read More

Int Ophthalmol Clin 2022 Apr;62(2):145-156

Int Forum Allergy Rhinol 2022 Mar 23. Epub 2022 Mar 23.

Department of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide, South Australia, Australia.

Background: Postoperative infections following endoscopic sinus surgery (ESS) impair wound healing and lead to poor outcomes. The aim of this study is to assess the effectiveness of Chitogel to reduce postoperative infections and restore a healthy microbiome following ESS.

Methods: In this double-blinded randomized control trial, 25 patients undergoing ESS were prospectively recruited. Read More

Spine Deform 2022 Jul 18;10(4):817-823. Epub 2022 Mar 18.

Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, 601 N. Caroline Street, JHOC 5223, Baltimore, MD, 21287, USA.

Purpose: To compare the incidence, timing, and microbiologic factors associated with late spinal infection (onset ≥ 6 months after index operation) in pediatric versus adult spinal deformity patients who underwent instrumented posterior spinal fusion (PSF).

Methods: We retrospectively queried our institutional database for pediatric (aged ≤ 21 years) and adult patients who underwent instrumented PSF from 2000 to 2015. Inclusion criteria were > 12-month follow-up, spinal arthrodesis spanning 4 or more levels, and idiopathic or degenerative spinal deformity. Read More

J Orthop Traumatol 2022 Mar 18;23(1):15. Epub 2022 Mar 18.

Department of Neurosurgery, Kepler University Hospital, Johannes Kepler University, Wagner-Jauregg Weg 15, 4020, Linz, Austria.

Study Design: Monocentric, prospective, observational study.

Objective: The clinical relevance of bacterial colonization of intervertebral discs is controversial. This study aimed to determine a possible relationship between bacterial and viral colonization and low-grade infection of the discs. Read More

Ophthalmic Surg Lasers Imaging Retina 2022 03 1;53(3):164-167. Epub 2022 Mar 1.

This article describes two cases of delayed-onset () endophthalmitis 1 month after cataract surgery manifesting with unusual epiretinal deposits. Both patients were referred for persistent inflammation after cataract surgery. After failing to respond to a vitreous tap with injection of antibiotics, the patients underwent pars plana vitrectomy and in one of the cases partial posterior capsulectomy for a posterior capsular plaque. Read More

J Cutan Pathol 2022 Jul 21;49(7):651-657. Epub 2022 Mar 21.

Department of Dermatology, Showa University School of Medicine, Tokyo, Japan.

We report two cases of eyebrow granulomas in patients who underwent a permanent eye makeup procedure. A rash was observed 16 months after the procedure in Case 1, and 10 years after the procedure in Case 2. Histopathologically, both patients exhibited noncaseating epithelioid cell granulomas. Read More

BMC Microbiol 2022 02 26;22(1):65. Epub 2022 Feb 26.

Instituto Universitario Fernández-Vega, Universidad de Oviedo, 33003, Oviedo, Spain.

Background: Cell surface glycosaminoglycans (GAGs) participate in many physiological and pathological processes, including infections and inflammatory response. Acne is a common chronic inflammatory skin disorder that affects the pilosebaceous unit and has a multifactorial etiology, including bacterial colonization of the hair follicle. This study aimed to investigate the participation of GAG in the adhesion of Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis to keratinocytes and fibroblasts of the skin by competition experiments and cell surface removal using specific liases. Read More

JAC Antimicrob Resist 2022 Mar 15;4(1):dlac009. Epub 2022 Feb 15.

Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, ON M5S 1A8, Canada.

Objectives: There is interest in doxycycline as prophylaxis against sexually transmitted infections (STIs), but concern about antimicrobial resistance (AMR). We conducted a systematic review (CRD42021273301) of the impact of oral tetracycline-class antibiotics on AMR in normal flora.

Methods: We searched MEDLINE, EMBASE, the Cochrane Library (1940-2021) and conference proceedings (2014-21) for randomized controlled trials in adults comparing daily oral tetracycline-class antibiotics to non-tetracycline controls. Read More

J Plast Reconstr Aesthet Surg 2022 May 13;75(5):1765-1779. Epub 2021 Sep 13.

Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. Electronic address:

The role of C. acnes biofilm production in the pathogenesis of breast implants infections has not been deeply assessed. We analyze biofilm production (in terms of biomass and metabolic activity) between 40 Cutibacterium acnes strains isolated from breast implants and 32 from other sites. Read More

J Shoulder Elbow Surg 2022 Jun 18;31(6):1115-1121. Epub 2022 Feb 18.

Orthopaedic Research Institute of Queensland, Townsville, QLD, Australia; James Cook University, Townsville, QLD, Australia.

Background: Preoperative skin preparations for total shoulder arthroplasty (TSA) are not standardized for Cutibacterium acnes eradication. Topical benzyl peroxide (BPO) and benzyl peroxide with clindamycin (BPO-C) have been shown to reduce the bacterial load of C acnes on the skin. Our aim was to investigate whether preoperative application of these topical antimicrobials reduced superficial colonization and deep tissue inoculation of C acnes in patients undergoing TSA. Read More

Transl Vis Sci Technol 2022 Feb;11(2):29

Department of Ophthalmology, First Affiliated Hospital of Northwest University, Xi'an No.1 Hospital, Xi'an, China.

Purpose: The purpose of this study was to explore if 16S rDNA amplicon sequencing can improve the conventional diagnosis of causative pathogens for bacterial corneal infection.

Methods: Corneal scraping and conjunctiva and eyelid margin swab samples from infected eyes of patients diagnosed with "bacterial corneal infection" and conjunctiva and eyelid margin swab samples from a random eye of healthy participants were collected. Each swab was used for both aerobic and anaerobic cultures and 16S rDNA amplicon sequencing. Read More

J Shoulder Elbow Surg 2022 May 11;31(5):897-905. Epub 2022 Feb 11.

Orthopedic Department, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

Background: Cutibacterium acnes is the main pathogen in periprosthetic shoulder infections. In acne vulgaris therapy, benzoyl peroxide-miconazole nitrate cream effectively reduces the superficial C acnes burden of the skin. Its additional potential in the subcutaneous and capsular layers (eg, for prevention of future periprosthetic shoulder infections) is unknown. Read More

Cureus 2021 Dec 28;13(12):e20771. Epub 2021 Dec 28.

General Surgery, Ente Ospedaliero Cantonale, Ospedale Regionale di Locarno, Locarno, CHE.

Prosthetic hip joint replacement is considered the operation of the 20th century because of its wide diffusion and good outcome. More than 1 million prostheses are implanted worldwide annually. Although hip arthroplasty is considered a safe procedure, different complications can occur in relation with surgery. Read More

S D Med 2021 Nov;74(11):523-526

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Cutibacterium acnes (C. acnes), known previously as Proprionebacterium acnes, is a common skin and mucous membrane colonizing bacteria. On rare occasions it has been associated with invasive infections in both immunocompetent and immunosuppressed patients. Read More

Biofilm 2022 Dec 9;4:100063. Epub 2021 Dec 9.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

(previously known as ) is frequently found on lipid-rich parts of the human skin. While is most known for its role in the development and progression of the skin disease acne, it is also involved in many other types of infections, often involving implanted medical devices. readily forms biofilms and there is growing evidence that biofilm formation by this Gram-positive, facultative anaerobic micro-organism plays an important role and is also involved in treatment failure. Read More

Vet Immunol Immunopathol 2022 Jan 9;243:110365. Epub 2021 Dec 9.

Croatian Veterinary Institute, 10000 Zagreb, Croatia. Electronic address:

Aujeszky's disease (AD) is a viral infectious disease caused by Suid herpesvirus 1 (SuHV-1). Vaccination and eradication of AD in domestic pigs is possible using marker vaccines with attenuated or inactivated SuHV-1, or subunit vaccines. However, vaccines with attenuated SuHV-1 have shown to be more potent in inducing strong cell-mediated immune response. Read More

Unfallchirurg 2021 Dec 8. Epub 2021 Dec 8.

Zentrum für Orthopädie und Unfallchirurgie, Unfallchirurgische Klinik, Universitätsklinikum OWL der Universität Bielefeld, Campus Klinikum Bielefeld, Teutoburger Straße 50, 33604, Bielefeld, Deutschland.

Periprosthetic infections with problematic and multiresistant pathogens represent a great challenge for trauma surgeons, especially when repetitive surgical débridement combined with calculated i.v. antibiotic treatment does not lead to resolution of the infection. Read More

Eur Spine J 2022 02 4;31(2):414-430. Epub 2021 Dec 4.

Department of Twin Research and Genetic Epidemiology, King's College London, 3rd and 4th Floor, Block D, South Wing, St. Thomas' Hospital, Westminster Bridge Rd., London, SE1 7EH, UK.

Purpose: Back pain is a major problem worldwide and is linked to intervertebral disc degeneration and Modic change. Several studies report growth of bacteria following extraction of degenerate discs at spine surgery. A pathophysiological role for infection in back pain has been proposed. Read More

PLoS One 2021 30;16(11):e0260384. Epub 2021 Nov 30.

Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Microorganisms in oral cavity are called oral microbiota, while microbiome consists of total genome content of microorganisms in a host. Interaction between host and microorganisms is important in nervous system development and nervous diseases such as Autism, Alzheimer, Parkinson and Multiple Sclerosis (MS). Bacterial infections, as an environmental factor in MS pathogenesis play role in T helper 17(Th17) increase and it enhancing the production of pro-inflammatory cytokines such as Interlukin-21(IL-21), IL-17 and IL -22. Read More