Search Our Scientific Publications & Authors

Antonie Van Leeuwenhoek 2021 May 7. Epub 2021 May 7.

Division of Clinical Bacteriology and Mycology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

Cutibacterium spp. play an increasing role in soft tissue and implant-associated infections. We isolated a novel Cutibacterium spp. Read More

Microorganisms 2021 Apr 26;9(5). Epub 2021 Apr 26.

Photosonix Medical, Inc., Fort Washington, PA 19034, USA.

Bacterial biofilms are highly resistant to antibiotics and have been implicated in the etiology of 60%-80% of chronic microbial infections. We tested a novel combination of low intensity ultrasound and blue light against biofilm and planktonic bacteria. A laboratory prototype was built which produced both energies uniformly and coincidently from a single treatment head, impinging upon a 4. Read More

Wiad Lek 2021 ;74(1):112-117

KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.

Objective: The aim of the study is to reveal in the experiment the morphological features of the infected skin wounds healing, which are a manifestation of acne vulgaris severe and very severe forms, using a gel with carbon dioxide extract of hops.

Patients And Methods: Materials and methods: An experimental study was carried out on 80 male WAG rats of three months of age. The animals were divided into 9 groups. Read More

Cureus 2021 Mar 3;13(3):e13668. Epub 2021 Mar 3.

Infectious Disease, Piedmont Athens Regional Medical Center, Athens, USA.

Infectious pericarditis does not always present with all the classic findings. Some of the traditional signs of fever, pleuritic chest pain, and frictional rub may be missing. This presents a diagnostic challenge, thus clinical suspicion is important. Read More

Arthroscopy 2021 04;37(4):1141-1142

Rothman Orthopaedic Institute - Thomas Jefferson University.

Although the clinical impact of positive cultures at the time of primary shoulder surgery remain unknown, much effort has been placed on identifying agents for skin preparation that reduce Cutibacterium acnes skin colonization. Although several randomized controlled trials of hydrogen peroxide use as part of the skin preparation exist, they are plagued by small sample sizes that lead to inadequate power or statistical fragility. Despite the lack of perfect data, our clinical experience and break-even analyses indicate value to routine use of hydrogen peroxide as part of the perioperative skin preparation prior to shoulder surgery. Read More

BMJ Case Rep 2021 Mar 25;14(3). Epub 2021 Mar 25.

Department of Medicine, Infectious Diseases, EHC, Morges, Vaud, Switzerland.

The early diagnosis of low-grade prosthetic shoulder joint infection is challenging due to the lack of clinical and laboratory signs. Patients present with atypical symptoms such as stiffness or failure to improve shoulder function. The diagnosis is often delayed with impact on long-term outcomes. Read More

Spartan Med Res J 2020 Jun 8;5(1):12463. Epub 2020 Jun 8.

Genesys Regional Medical Center.

Context: Cutibacterium acnes (C. Acnes, formerly known as Propionibacterium acnes) are slow growing, gram positive, anaerobic bacilli. C. Read More

Spine Deform 2021 May 8;9(3):757-767. Epub 2021 Feb 8.

Northern California Regional Spine Center, Kaiser Permanente Oakland Medical Center, 3600 Broadway, Suite 15, Oakland, CA, 94611, USA.

Study Design: Retrospective review of hospital charts.

Objective: (1) To determine the microbiological profile of patients with surgical site infections following posterior spinal fusion surgery (PSF) for Adolescent Idiopathic scoliosis (AIS). (2) To study the treatment outcome of patients with surgical site infections (SSI) following surgery for AIS. Read More

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2020 Dec 8;41(3):49-57. Epub 2020 Dec 8.

Institute for Health and Sport, Victoria University, Melbourne VIC, Australia.

Plants that are primarily used as a food source commonly have undervalued biological properties beyond the basic supply of nutrients. One important example of this are the antimicrobial properties of plants. Inclusion of natural and food grade antimicrobial ingredients in recipes to prevent food spoilage and disease transmission, or in cosmetic products to prevent transient and pathogenic bacteria would have world-wide public health implications. Read More

Molecules 2021 Jan 22;26(3). Epub 2021 Jan 22.

Department of Human Development and Family Studies, National Taiwan Normal University, Taipei 106, Taiwan.

(formerly ) is one of the major bacterial species responsible for acne vulgaris. Numerous bioactive compounds from Linn. var. Read More

J Lab Physicians 2020 Dec 30;12(4):233-238. Epub 2020 Dec 30.

Department of Microbiology, All India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh, India.

  ( ) is an emerging pathogen that is highly resistant to antibiotics and is capable of causing persistent infections that are difficult to treat.  Acne vulgaris patients visiting dermatology OPD of our tertiary care hospital during the study period of 2 months were recruited. Skin swabs were collected, and the sample was processed on 5% sheep-blood agar for anaerobic culture by the GasPak method. Read More

ACS Omega 2021 Jan 22;6(1):762-774. Epub 2020 Dec 22.

Molecular Biotechnology Laboratory, School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

The single-chain variable fragment (scFv) of monoclonal antibodies is a promising recombinant nanostructure for various medical applications, including bioimaging and targeted therapy. While numerous scFv antibodies against eukaryotic cell surface proteins (especially cancer biomarkers) have been generated and engineered to suit various purposes, only a few specific scFv against bacterial cell surfaces have been developed, especially those of human origin. Recent incidents of emerging multidrug-resistant pathogenic bacteria and the realization of the importance of a balanced microbiota on the health of the host has led to more interests in the development of recombinant antibacterial antibodies as a detection probe or targeted therapy for bacterial infections. Read More

Poult Sci 2021 Jan 12;100(1):283-295. Epub 2020 Oct 12.

Department of Animal Science, University of Minnesota, Saint Paul, MN 55108, USA. Electronic address:

A dairy-originated probiotic bacterium, Propionibacterium freudenreichii subsp. freudenreichii B3523 (PF) was found to be effective in reducing multidrug-resistant Salmonella Heidelberg (MDR SH) colonization in turkey poults (2-week-old) and growing (7-week-old) and finishing (12-week-old) turkeys. In this study, we explored the potential for microbiome modulation in the cecum of turkeys of different age groups due to PF supplementation in conjunction with MDR SH challenge. Read More

Clin Infect Dis 2020 Dec 10. Epub 2020 Dec 10.

Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, the Netherlands.

Background: Cutibacterium species are common pathogens in periprosthetic joint infections (PJI). These infections are often treated with β-lactams or clindamycin as monotherapy, or in combination with rifampin. Clinical evidence supporting the value of adding rifampin for treatment of Cutibacterium PJI is lacking. Read More

Shoulder Elbow 2020 Dec 9;12(6):390-398. Epub 2019 Aug 9.

Mayo Clinic, Rochester, USA.

Introduction: is a recognized culprit for implant-associated infections, but positive cultures do not always indicate clinically relevant infection. Studies have shown a correlation between the β-hemolytic phenotype of and its infectious capacity, but correlation with genetic phylotype has not been performed in literature. The purpose of this study is to evaluate β-hemolysis phenotype, genetic phylotype, and mid-term clinical outcomes of isolated from orthopedic surgical sites. Read More

Sci Rep 2020 12 1;10(1):20901. Epub 2020 Dec 1.

AO Research Institute Davos, Clavadelerstrasse 8, 7270, Davos Platz, Switzerland.

Subclinical infection associated with orthopedic devices can be challenging to diagnose. The goal of this study was to evaluate longitudinal, microcomputed tomography (microCT) imaging in a rat model of subclinical orthopedic device-related infection caused by Staphylococcus epidermidis and four different Cutibacterium (previously Propionibacterium) acnes strains, and compare outcomes with non-inoculated and historical S. aureus-inoculated controls. Read More

Front Immunol 2020 15;11:571334. Epub 2020 Oct 15.

Max Perutz Labs, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Vienna Biocenter, Vienna, Austria.

(previously ) is an anaerobic, Gram-positive commensal of the human body. The bacterium has been associated with a variety of diseases, including acne vulgaris, prosthetic joint infections, prostate cancer, and sarcoidosis. The accumulation of in diseases such as acne and prostate cancer has been shown to correlate with enhanced inflammation. Read More

Eur J Clin Microbiol Infect Dis 2021 Apr 30;40(4):665-671. Epub 2020 Oct 30.

Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Göztepe Eğitim ve Araştırma Hastanesi, İstanbul Medeniyet Üniversitesi, Dr. Erkin Caddesi, 34722, Kadıköy, Istanbul, Turkey.

Prosthetic joint infections cause serious morbidity and mortality among joint arthroplasty patients. Rifampin-accompanied antibiotic regimens are recommended for gram-positive infections. This study aimed to combine current evidence supporting the rifampin supplement to an effective antibiotic in the treatment of prosthetic joint infections. Read More

Int J Mol Sci 2020 Oct 24;21(21). Epub 2020 Oct 24.

Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.

Understanding the importance of oral microbiota in human health and disease also leads to an expansion of the knowledge on functional, metabolic, and molecular alterations directly contributing to oral and systemic pathologies. To date, a compelling number of studies have documented the crucial role of some oral cavity-occurring microbes in the initiation and progression of cancers. Although this effect was noted primarily for spp. Read More

Clin Infect Dis 2020 Oct 24. Epub 2020 Oct 24.

Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Although the healthy human skin microbiome has been the subject of recent studies, it is not known whether alterations among commensal microbes contribute to surgical site infections (SSIs). The objective of this study was to characterize temporal and spatial variation in the skin microbiota of patients undergoing colorectal surgery and to determine if dysbiosis contributes to SSIs.

Methods: Sixty (60) adults scheduled to undergo elective colon or rectal resection were identified by convenience sampling. Read More

Vaccine 2020 11 9;38(48):7581-7584. Epub 2020 Oct 9.

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia, Modena, Italy; Second Opinion Medical Network, Modena, Italy.

Today, Coronavirus Disease 2019 (COVID-19) is a global public health emergency and vaccination measures to counter its diffusion are deemed necessary. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the disease, unleashes a T-helper 2 immune response in those patients requiring intensive care. Here, we illustrate the immunological mechanism to train the immune system towards a more effective and less symptomatic T-helper 1 immune response, to be exploited against SARS-CoV-2. Read More

Dis Mon 2021 Apr 9;67(4):101103. Epub 2020 Oct 9.

Department of Pediatric and Adolescent Medicine, Western Michigan University, Homer Stryker M.D. School of Medicine, 1000 Oakland Drive, Kalamazoo, MI 49008-1284, United States.

Acne vulgaris is a chronic, inflammatory, skin condition that involves the pilosebaceous follicles and is influenced by a variety of factors including genetics, androgen-stimulation of sebaceous glands with abnormal keratinization, colonization with Cutibacterium acnes (previously called Propionibacterium acnes), and pathological immune response to inflammation. Acne can occur at all ages and this discussion focuses on the first three decades of life. Conditions that are part of the differential diagnosis and/or are co-morbid with acne vulgaris are also considered. Read More

Microorganisms 2020 Sep 26;8(10). Epub 2020 Sep 26.

Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA.

The human forearm skin microbiome ecosystem contains rich and diverse microbes, which are influenced by environmental exposures. The microbial representatives can be exchanged between human and environment, specifically animals, by which they share certain or similar epidermal microbes. Livestock and poultry are the microbial sources that are associated with the transmission of community-based pathogenic infections. Read More

Biomed Chromatogr 2020 Nov 7;34(11):e4977. Epub 2020 Sep 7.

Institute of Biotechnology, University of Caxias do Sul, Caxias do Sul, Brazil.

Clindamycin is used for infections caused by Gram-positive and Gram-negative anaerobic pathogens and Gram-positive aerobes. Propionibacterium acnes is an important opportunistic microorganism of the human skin and is related to prostatitis. An LC-electrospray ionization-quadrupole time-of-flight-MS method was validated for determining clindamycin concentrations in plasma and prostate microdialysate. Read More

Zhonghua Yan Ke Za Zhi 2020 Jul;56(7):519-523

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.

To investigate the role of metagenomic sequencing in the diagnosis of infectious uveitis. Cross-sectional study. A total of 19 vitreous specimens of patients with suspected infectious uveitis from March 2016 to July 2018 in Beijing Tongren Hospital were collected, including 8 males and 11 females, 19 to 68 years old. Read More

Case Rep Infect Dis 2020 25;2020:8883907. Epub 2020 Jul 25.

Internal Medicine, Division of Infectious Disease, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 461 Hofheimer Hall, Norfolk, VA 23507, USA.

(formerly ) () is a commensal bacteria commonly found on the human skin and in the mouth. While the virulence of is low in humans, it does produce a biofilm and has been identified as an etiologic agent in a growing number of implant-associated infections. infections can prove diagnostically challenging as laboratory cultures can often take greater than 5 days to yield positive results, which are then often disregarded as contaminant. Read More

Antimicrob Resist Infect Control 2020 07 29;9(1):119. Epub 2020 Jul 29.

Department of Infectious Diseases, Rochester Regional Health, 1425 Portland Ave, Rochester, NY, 14621, USA.

Background: Rat bite fever is a systemic febrile illness caused by infection with the Gram-negative bacillus Streptobacillus moniliformis following a bite, scratch, or contact with excrement. Only 26 cases of native valve endocarditis have been reported to date. We could find no other reports of severe Streptobacillus endocarditis requiring valve replacement in a young, pregnant patient. Read More

Molecules 2020 Jul 25;25(15). Epub 2020 Jul 25.

School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

One new dibenzocycloheptene, validinol (), and one butanolide firstly isolated from the natural source, validinolide (), together with 17 known compounds were isolated from the stem of . Among the isolates, lincomolide A (), secosubamolide (), and cinnamtannin B1 () exhibited potent inhibition on both superoxide anion generation (IC values of 2.98 ± 0. Read More

Antibiotics (Basel) 2020 Jul 22;9(8). Epub 2020 Jul 22.

Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy.

The main reason for root canal treatment failure is the persistence of microorganisms after therapy, or the recontamination of the root canal system due to an inadequate seal. In the mouth, spp. constitute a significant part of the normal flora, which is indicative of their ability to adhere to oral tissue and resist cleansing mechanisms, such as salivary flow. Read More

Int J Mol Sci 2020 Jul 19;21(14). Epub 2020 Jul 19.

Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 32001, Taiwan.

The probiotic activity of skin () bacteria can elicit diverse biological functions via the fermentation of various carbon sources. Here, we found that polyethylene glycol (PEG)-8 Laurate, a carbon-rich molecule, can selectively induce the fermentation of , not (), a bacterium associated with acne vulgaris. The PEG-8 Laurate fermentation of remarkably diminished the growth of and the -induced production of pro-inflammatory macrophage-inflammatory protein 2 (MIP-2) cytokines in mice. Read More