6,998 results match your criteria Propionibacterium Infections


Gut microbiota signatures in cystic fibrosis: Loss of host CFTR function drives the microbiota enterophenotype.

PLoS One 2018 6;13(12):e0208171. Epub 2018 Dec 6.

Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background: Cystic fibrosis (CF) is a disorder affecting the respiratory, digestive, reproductive systems and sweat glands. This lethal hereditary disease has known or suspected links to the dysbiosis gut microbiota. High-throughput meta-omics-based approaches may assist in unveiling this complex network of symbiosis modifications. Read More

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December 2018
1 Read

Anti-acne properties of hydrophobic fraction of red ginseng (Panax ginseng C.A. Meyer) and its active components.

Phytother Res 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Korea University, Sejong, Republic of Korea.

Acne is a chronic inflammatory disease of the skin that occurs when bacteria abnormally grow in hair follicles. The most common treatment is antibiotics, but they are limited due to antibiotic resistance. The purpose of this study was to identify the active ingredients of the antimicrobial effects of red ginseng (Panax ginseng C. Read More

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December 2018

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections.

Eur Spine J 2018 Dec 1. Epub 2018 Dec 1.

Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.

Purpose: The presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. Read More

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December 2018
1 Read

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5752-5761

University of Houston College of Optometry, Houston, Texas, United States.

Purpose: The purpose of this study was to explore differences in genotype, ocular surface microbiome, tear inflammatory markers, and environmental and behavioral exposures in soft contact lens (SCL) wearers with and without a history of corneal infiltrative events (CIEs).

Methods: Nine SCL wearers with a recent CIE and nine age-, sex-, and SCL material- and modality-matched controls were enrolled. The Contact Lens Risk Survey, slit-lamp examination data, basal tears, conjunctival microbial cultures, and peripheral blood samples were collected. Read More

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December 2018
3 Reads

Changes in gut bacterial communities in canaries infected by Macrorhabdus ornithogaster.

Avian Pathol 2018 Nov 30:1-29. Epub 2018 Nov 30.

a Department of Veterinary Sciences , University of Torino , Largo Braccini 2, 10095 Grugliasco (Torino) , Italy.

Macrorhabdus ornithogaster is an opportunistic yeast that colonizes the gastric mucosa of many avian species. Until now, no studies have been focused on about the influence of a gastric infection on the balance of the intestinal microbiota of birds. In this study, 44 fecal samples from individual canaries, with and without M. Read More

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November 2018

A low-power ultrasound attenuation improves the stability of biofilm and hydrophobicity of Propionibacterium freudenreichii subsp. freudenreichii DSM 20271 and Acidipropionibacterium jensenii DSM 20535.

Food Microbiol 2019 Apr 22;78:104-109. Epub 2018 Oct 22.

Department of the Science of Agriculture, Food and Environment, University of Foggia, Foggia, Italy. Electronic address:

The main topic of this paper was to study the effect of ultrasound-attenuation (US) on the surface properties of propionibacteria (Acidipropionibacterium jensenii DSM 20535 and Propionibacterium freudenreichii DSM 20271). A preliminary screening was done by using different power levels (40 and 60%) and treatment times (4, 6, and 8 min); immediately after sonication, acidification and viable count were tested. The best combinations to avoid post-acidification after 6 h were the following: A. Read More

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Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study.

PLoS One 2018 29;13(11):e0208144. Epub 2018 Nov 29.

Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.

Most patients with chronic lower back pain (CLBP) exhibit degenerative disc disease. Disc specimens obtained during initial therapeutic discectomies are often infected/colonized with Propionibacterium acnes, a Gram-positive commensal of the human skin. Although pain associated with infection is typically ascribed to the body's inflammatory response, the Gram-positive bacterium Staphylococcus aureus was recently observed to directly activate nociceptors by secreting pore-forming α-hemolysins that disrupt neuronal cell membranes. Read More

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November 2018
1 Read

Transcellular traversal of the blood-brain barrier by the pathogenic Propionibacterium acnes.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

Background: Propionibacterium acnes (P. acnes) is an anaerobe commonly stay in the body as part of the commensal microbiota, and a dominant bacterium of the human skin and hair follicles. It has been found that this bacterium could participate in brain inflammation that causes Alzheimer's disease (AD) and Parkinson's disease (PD). Read More

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November 2018

Perinatal probiotic intervention prevented allergic disease in a Caesarean-delivered subgroup at 13-year follow-up.

Clin Exp Allergy 2018 Nov 25. Epub 2018 Nov 25.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: The long-term effects of probiotic intervention for primary prevention of allergic diseases are not well known. We previously reported less eczema until 10 years in our probiotic intervention trial.

Objective: To investigate the effect of early probiotic intervention on the prevalence of allergic diseases up to 13 years of age. Read More

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November 2018

Different laboratory populations similar bacterial profile? The case of Glossina palpalis gambiensis.

BMC Microbiol 2018 Nov 23;18(Suppl 1):148. Epub 2018 Nov 23.

Department of Environmental and Natural Resources Management, University of Patras, 2 Seferi St, 30100, Agrinio, Greece.

Background: Microbiota plays an important role in the biology, ecology and evolution of insects including tsetse flies. The bacterial profile of 3 Glossina palpalis gambiensis laboratory colonies was examined using 16S rRNA gene amplicon sequencing to evaluate the dynamics of the bacterial diversity within and between each G. p. Read More

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November 2018
1 Read

In Vitro Antioxidant and Anti- Activities of Cold Water, Hot Water, and Methanol Extracts, and Their Respective Ethyl Acetate Fractions, from L Roots.

Molecules 2018 Nov 16;23(11). Epub 2018 Nov 16.

Daeduck Lab. Co. Ltd., Daejeon 34024, Korea.

Identification of medicinal plants and naturally derived compounds as new natural antioxidant and antibacterial sources for topical acne treatment has long been important. To determine anti- activity and in vitro antioxidant activities, L. root (SOR) was extracted with cold water (CWE), hot water (HWE), and methanol (ME), and each extract was fractionated successively with hexane, ethyl acetate (EA), and butanol to determine whether the activities could be attributed to the total phenolic, flavonoid, terpenoid, and condensed tannin contents. Read More

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November 2018
3 Reads

Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica.

Biosci Biotechnol Biochem 2018 Nov 19:1-8. Epub 2018 Nov 19.

a State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai , People's Republic of China.

Madecassoside is a major pentacyclic triterpene saponin from Centella asiatica with multiple pharmaceutical activities. In this study, we focused on its Propionibacterium acnes related anti-inflammation and skin hydration activities, both of which play important roles in skin homeostasis and barrier function. Madecassoside significantly inhibited the pro-inflammatory cytokine IL-1β, TLR2 and nuclear translocation of NF-κB in P. Read More

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November 2018
3 Reads

Development of Rifampicin-Indocyanine Green-Loaded Perfluorocarbon Nanodroplets for Photo-Chemo-Probiotic Antimicrobial Therapy.

Front Pharmacol 2018 2;9:1254. Epub 2018 Nov 2.

Department of Biomedical Sciences and Engineering, National Central University, Taoyuan City, Taiwan.

Acne vulgaris, generally resulted from overgrowth of (), is one of the most difficult-to-treat facial dermatoses and more than 90% of adolescents experienced the disease worldwide. Because the innate non-lymphoid immune system cannot effectively eliminate excessive from the skin surface, so far the therapy of acne vulgaris is still mainly dependent on antibiotic treatment. However, long-term or overdose of antibiotics may initiate microbial drug resistance and/or generate unexpected side effects that seriously hamper the use of antibiotics in the clinic. Read More

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November 2018
2 Reads

Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: in vitro and in vivo studies.

Drug Dev Ind Pharm 2018 Nov 16:1-10. Epub 2018 Nov 16.

a Centre for Biomedical Engineering , Indian Institute of Technology , New Delhi , India.

The study highlights the significance of co-application of bioactive components into liposomal gel formulations and their comparison to azithromycin for treatment of Acne. A Design of Experiments (DoE) approach was utilized to obtain optimized liposomal formulation encapsulating curcumin, with size and zeta potential of ∼100 nm and ∼14 mV, respectively, characterized by DLS, HR-TEM, FESEM, and AFM. The curcumin liposomal dispersion depicted excellent stability over the period of 60 days, which was further converted in gel form using Carbopol. Read More

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November 2018
7 Reads

Comparing Standard Versus Extended Culture Duration in Acute Hip and Knee Periprosthetic Joint Infection.

J Am Acad Orthop Surg 2018 Nov 13. Epub 2018 Nov 13.

From the Department of Orthopaedic Surgery (Dr. Klement, Dr. Cunningham, Dr. Wooster, Dr. Wellman, Dr. Bolognesi), Duke University Medical Center, and the Department of Biostatistics and Bioinformatics (Dr. Green), Duke University School of Medicine, Durham, NC, and Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL (Dr. Garrigues).

Introduction: Periprosthetic joint infection (PJI) is a devastating complication of hip and knee arthroplasties. Surgical cultures are essential for the diagnosis and treatment of PJI. Yet, the ideal culture duration remains unclear. Read More

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November 2018
2 Reads

Alpha- and gamma-mangostins exhibit anti-acne activities via multiple mechanisms.

Immunopharmacol Immunotoxicol 2018 Nov 13:1-8. Epub 2018 Nov 13.

a Institute of Life Science , Wenzhou University , Wenzhou , China.

Objective: Acne is a chronic skin disease that involves four key pathogenic factors: excess sebum production, ductal epidermal hyperproliferation, Propionibacterium acnes (P. acnes) colonization, and skin inflammation. Mangostins are well-known for their anti-bacterial and anti-inflammatory effects, suggesting that mangostins may have therapeutic potential for acne. Read More

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November 2018
8 Reads

The Cheese Matrix Modulates the Immunomodulatory Properties of CIRM-BIA 129 in Healthy Piglets.

Front Microbiol 2018 29;9:2584. Epub 2018 Oct 29.

STLO, INRA, Agrocampus Ouest, Rennes, France.

is a beneficial bacterium, used as a cheese starter, which presents versatile probiotic properties. These properties are strain-dependent. We hypothesized they may also be delivery vehicle-dependent. Read More

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October 2018
3 Reads

The serum level of C-reactive protein alone cannot be used for the diagnosis of prosthetic joint infections, especially in those caused by organisms of low virulence.

Bone Joint J 2018 Nov;100-B(11):1482-1486

Center for Musculoskeletal Surgery, Charité - University Medicine Berlin, Berlin, Germany.

Aims: The aim of this study was to determine the prevalence and characteristics of C-reactive protein (CRP)-negative prosthetic joint infection (PJI) and evaluate the influence of the type of infecting organism on the CRP level.

Patients And Methods: A retrospective analysis of all PJIs affecting the hip or knee that were diagnosed in our institution between March 2013 and December 2016 was performed. A total of 215 patients were included. Read More

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November 2018
1 Read

Urine Bacteria-Derived Extracellular Vesicles and Allergic Airway Diseases in Children.

Int Arch Allergy Immunol 2018 Nov 9:1-9. Epub 2018 Nov 9.

Department of Pediatrics, Inha University School of Medicine, Incheon, Republic of

Background: Microbiota and human allergic airway diseases have been proven to be interrelated. Bacteria-derived extracellular vesicle (EV)s are known to play important roles in interbacterial and human-bacteria communications, but their relationship with allergies has not been examined yet. Urine EVs were investigated to determine whether they could be used as biomarkers for monitoring allergic airway diseases in children. Read More

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November 2018
14 Reads

Efficacy of two plant extracts against acne vulgaris: Initial results of microbiological tests and cell culture studies.

J Cosmet Dermatol 2018 Nov 9. Epub 2018 Nov 9.

Biota Research & Development Center, Istanbul, Turkey.

Background: Acne vulgaris is a common skin disease characterized by increased sebum production, inflammation, and colonization of Propionibacterium acnes (P. acnes) on pilosebaceous follicles.

Aims: To determine the efficacy of two different plant extracts against P. Read More

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November 2018
3 Reads

Prevalence and quantification of contamination of knitted cotton outer gloves during hip and knee arthroplasty surgery.

Arch Orthop Trauma Surg 2018 Nov 7. Epub 2018 Nov 7.

Division of Orthopaedics and Traumatology, Cantonal Hospital Winterthur, Brauerstrasse 15, P.O. Box 834, 8401, Winterthur, Switzerland.

Introduction: Knitted cotton outer gloves offer protection against surgical glove perforation and provide improved grip on instruments. These gloves absorb blood and other fluids during surgery, and may therefore also accumulate contaminating bacteria. To date, there is no published data on microbial contamination of such gloves during surgery. Read More

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November 2018
5 Reads

Single Double Skin Preparation for Infection Prevention in Proximal Humeral Fracture Surgery.

Biomed Res Int 2018 14;2018:8509527. Epub 2018 Oct 14.

Surgical Sciences Department, Mauriziano-Umberto I Hospital, University of Torino, 10128 Turin, Italy.

Preoperative skin preparation plays a major role in preventing postoperative infections. This study aims to compare a single skin preparation (povidone iodine) with a double skin preparation (chlorhexidine gluconate followed by povidone iodine). Forty patients affected by proximal humeral fracture were included in the study. Read More

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October 2018
4 Reads

Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti- Activity.

Int J Mol Sci 2018 Nov 3;19(11). Epub 2018 Nov 3.

Department of Medical Science, College of Medical Science, SoonChunHyang University, 22 SoonChunHyang-ro, Asan, Chungnam 31538, Korea.

, referred to as black ginger, has traditionally been used as a health-promoting alternative medicine. In this study, we examined the anti-inflammatory, sebostatic, and anti- activities of extract. The extract significantly down-regulated the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) level. Read More

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November 2018
6 Reads

Propionibacterium acnes induces discogenic low back pain via stimulating nucleus pulposus cells to secrete pro-algesic factor of IL-8/CINC-1 through TLR2-NF-κB p65 pathway.

J Mol Med (Berl) 2018 Nov 6. Epub 2018 Nov 6.

Department of Orthopedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China.

Latent infection of Propionibacterium acnes was considered as a new pathogeny for low back pain (LBP); however, there is no credible animal evidence or mechanism hypothesis. This study proved that P. acnes is a causative pathogen of bacteria-induced LBP and investigated its underlying mechanism. Read More

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November 2018
4 Reads

HPV infection and bacterial microbiota in breast milk and infant oral mucosa.

PLoS One 2018 5;13(11):e0207016. Epub 2018 Nov 5.

Department of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.

Objective: We investigated the association between bacterial microbiota in breast milk and the infant mouth. The influence of human papilloma virus (HPV) infection on infant oral microbiota was also assessed.

Material And Methods: Altogether 35 breast milk and 35 infant oral samples with known HPV status were selected from the Finnish Family HPV Study cohort. Read More

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November 2018
6 Reads

Colonization of Cutibacterium avidum during infant gut microbiota establishment.

FEMS Microbiol Ecol 2019 Jan;95(1)

Laboratory of Food Biotechnology, Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH-Zurich, 8092 Zurich, Switzerland.

Establishment of the infant gut microbiota affects gut maturation and influences long-term health. Cutibacterium (formerly Propionibacterium) have been identified as early colonizers, but little is known about their function. Using a cultivation-dependent and -independent approach, we determined Cutibacterium prevalence, diversity and functional potential. Read More

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January 2019
5 Reads

Microbiota and Metabolite Profiling of Spoiled Spanish-Style Green Table Olives.

Metabolites 2018 Oct 31;8(4). Epub 2018 Oct 31.

Food Biotechnology Department, Instituto de la Grasa-CSIC, Utrera road, km 1, 41013 Seville, Spain.

The aim of the present study was to assess the malodorous spoilages of Spanish-style green table olives through microbial and metabolite composition using current measuring techniques (e.g., high-throughput DNA sequencing, headspace solid-phase microextraction combined with gas chromatography-mass spectrometry). Read More

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October 2018
1 Read

Gut microbial divergence between two populations of the hadal amphipod .

Appl Environ Microbiol 2018 Oct 26. Epub 2018 Oct 26.

Division of Life Science, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China

Hadal environments sustain diverse microorganisms. A few studies have investigated hadal microbial communities consisting of free-living or particle-associated bacteria and archaea. However, animal-associated microbial communities in hadal environments remain largely unexplored, and comparative analyses of animal gut microbiota between two isolated hadal environments have never been done so far. Read More

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October 2018
4 Reads

sp. nov., sp. nov., sp. nov. and sp. nov., isolated from porcine nasal swabs in the Münster region, Germany.

New Microbes New Infect 2018 Nov 21;26:114-117. Epub 2018 Sep 21.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

We report the core features of strain 1a5R-CH16 sp. nov., strain 2a1I-BL09 sp. Read More

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November 2018

The combination of EBUS-TBNA and the PAB antibody led to a successful treatment for lung cancer in a patient with asymptomatic sarcoidosis mimicking nodal metastasis.

Respir Med Case Rep 2018 18;25:296-299. Epub 2018 Oct 18.

Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan.

Correct staging of lung cancer is important for the selection of the best therapy, but discriminating between lymphadenopathy from lung cancer and from sarcoidosis by imaging examinations is difficult. Additionally, distinguishing lymphadenopathy of sarcoidosis from sarcoid reactions which are sometimes caused by lung cancer is difficult on imaging and pathological findings. A 73-year-old woman was diagnosed as lung cancer clinical T1bN3M0 stage ШB based on false-positive F-fluoro-2-deoxyglucose positron emission tomography uptake. Read More

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October 2018
5 Reads

Highly efficient and biocompatible nanoparticle-based photosensitizer for treatment of acne vulgaris.

Nanomedicine (Lond) 2018 Oct 19;13(20):2629-2636. Epub 2018 Oct 19.

Department of Chemistry, University of Cincinnati, Cincinnati 45221, OH, USA.

Aim: Nanoparticle-based photosensitizers containing silver core and mesoporous silica shell with hematoporphyrin IX embedded were developed to treat vulgaris photodynamically.

Materials & Methods: The hybrid photosensitizers were dispersed in 30% polyethylene glycol (PEG-200) solution and used for the photodynamic treatment of Staphylococcus epidermidis and Propionibacterium acnes under the illumination of a portable LED (∼410 nm).

Results: After a 5 min illumination by the LED, the hybrid photosensitizers of 50 μg/ml displayed killing efficacy of approximately 5-log for S. Read More

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October 2018
5 Reads

Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.

Front Cell Infect Microbiol 2018 4;8:346. Epub 2018 Oct 4.

Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India.

Several scalp microbiome studies from different populations have revealed the association of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and dandruff scalp of 140 Indian women. Read More

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October 2018
6 Reads
2.620 Impact Factor

Japanese Antibacterial Drug Management for Cardiac Sarcoidosis (J-ACNES): A multicenter, open-label, randomized, controlled study.

J Arrhythm 2018 Oct 31;34(5):520-526. Epub 2018 Aug 31.

Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center Osaka Japan.

Background: Cardiac sarcoidosis (CS) is a noncaseating granulomatous disease of unknown etiology. Lifelong immunosuppressive therapy, most frequently using corticosteroids, is a standard therapy to control hypersensitivity of immune reactions and prevent inflammation. However, it sometimes causes various systemic adverse effects and requires dose escalation. Read More

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October 2018
3 Reads

Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants.

Microbiome 2018 Oct 16;6(1):182. Epub 2018 Oct 16.

Immunobiology Research Programme, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.

Background: Infants born by caesarean section or receiving antibiotics are at increased risk of developing metabolic, inflammatory and immunological diseases, potentially due to disruption of normal gut microbiota at a critical developmental time window. We investigated whether probiotic supplementation could ameliorate the effects of antibiotic use or caesarean birth on infant microbiota in a double blind, placebo-controlled randomized clinical trial. Mothers were given a multispecies probiotic, consisting of Bifidobacterium breve Bb99 (Bp99 2 × 10 cfu) Propionibacterium freundenreichii subsp. Read More

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October 2018

The role of Cutibacterium acnes in auto-inflammatory bone disorders.

Eur J Pediatr 2018 Oct 15. Epub 2018 Oct 15.

Department of Paediatrics, The University of Melbourne, Parkville, Australia.

Chronic nonbacterial osteomyelitis (CNO) and SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome are auto-inflammatory disorders manifesting as chronic inflammation of bones and joints, which in SAPHO is often accompanying by skin changes. The aetiology of these diseases is unknown, but includes genetic, infectious and immunological components. It has been proposed that Cutibacterium (formerly Propionibacterium) acnes plays a role in the pathogenesis. Read More

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October 2018
6 Reads

TNIP1 Regulates -Induced Innate Immune Functions in Epidermal Keratinocytes.

Front Immunol 2018 24;9:2155. Epub 2018 Sep 24.

MTA-SZTE Dermatological Research Group, Szeged, Hungary.

Human skin cells recognize the presence of the skin microbiome through pathogen recognition receptors. Epidermal keratinocytes are known to activate toll-like receptors (TLRs) 2 and 4 in response to the commensal (, formerly known as ) bacterium and subsequently to induce innate immune and inflammatory events. These events may lead to the appearance of macroscopic inflammatory acne lesions in puberty: comedos, papules and, pustules. Read More

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September 2018
5 Reads

Synthesis and evaluation of biological activity of benzoxaborole derivatives of azithromycin.

J Antibiot (Tokyo) 2018 Oct 12. Epub 2018 Oct 12.

Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Leninskie Gory, Moscow, Russia.

Novel benzoxaborole derivatives of azithromycin in which benzoxaborole residue is attached to the 4″-hydroxy-group of azithromycin have been synthesized. Antibacterial activity of synthesized derivatives in comparison with azithromycin was tested on a panel of Gram-positive and Gram-negative bacterial strains. All the investigated compounds demonstrated broad spectrum of antibacterial activity being in general more active against Gram-positive strains. Read More

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October 2018
2 Reads

A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes.

MBio 2018 Oct 9;9(5). Epub 2018 Oct 9.

Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

Cutaneous squamous cell carcinoma (SCC) is the second-most-common cancer in Australia. The majority of SCCs progress from premalignant actinic keratosis (AK) lesions that form on chronically sun-exposed skin. The role of skin microbiota in this progression is not well understood; therefore, we performed a longitudinal microbiome analysis of AKs and SCCs using a cohort of 13 SCC-prone immunocompetent men. Read More

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October 2018
2 Reads

Killed Propionibacterium acnes enhances immunogenicity and tumor growth control of a dendritic-tumor cell hybrid vaccine in a murine melanoma model.

PLoS One 2018 9;13(10):e0205148. Epub 2018 Oct 9.

Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil.

Hybrid vaccines have been investigated in clinical and experimental studies once expresses total antigens of a tumor cell combined with the ability of a dendritic cell (DC) to stimulate immune responses. However, the response triggered by these vaccines is often weak, requiring the use of adjuvants to increase vaccine immunogenicity. Killed Propionibacterium acnes (P. Read More

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October 2018
1 Read

Synthesis of prebiotic galactooligosaccharides from lactose and lactulose by dairy propionibacteria.

Food Microbiol 2019 Feb 27;77:93-105. Epub 2018 Aug 27.

Laboratorio de Ecofisiología Tecnológica, CERELA-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucumán, Argentina. Electronic address:

The potential of probiotic bacteria to produce prebiotic oligosaccharides by transgalactosylation has been minimally studied. In this work, we screened the β-galactosidase (β-gal) activity of dairy propionibacteria (PAB) isolated from Argentinean foods to select strains for the synthesis of oligosaccharides from lactose (GOS) and lactulose (OsLu). PAB, when grown in a medium with lactose as a carbon source, were disrupted, and the cell-free extracts were assayed for β-gal activity. Read More

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February 2019

Benzoyl peroxide + chlorhexidine versus chlorhexidine alone skin preparation to reduce Propionibacterium acnes: a randomized controlled trial.

ANZ J Surg 2018 Nov 8;88(11):1182-1186. Epub 2018 Oct 8.

Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand.

Background: Traditional skin preparation for shoulder surgery is not specific for Propionibacterium acnes. Topical benzoyl peroxide for 48 h preoperatively has been shown to reduce the bacterial load of P. acnes on the skin. Read More

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November 2018
1 Read

Isolation and characterization of a galactose-specific lectin (EantH) with antimicrobial activity from Euphorbia antiquorum L. latex.

Int J Biol Macromol 2018 Dec 2;120(Pt B):1846-1854. Epub 2018 Oct 2.

Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Rangsit Center, Pathum Thani 12121, Thailand.

A homodimeric 75 kDa lectin with hemagglutination activity (HA) was purified from the crude latex of Euphorbia antiquorum L. by two types of chromatography, on cation exchange (HiTrap SP FF) and hydrophobic HiTrap Phenyl FF (high sub) columns. The purified protein was designated EantH, and is classified as a galactose-specific thermostable lectin. Read More

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December 2018
7 Reads

Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris.

Microbiome 2018 Oct 2;6(1):177. Epub 2018 Oct 2.

Department of Dermatology, University of California San Diego, La Jolla, CA, 92037, USA.

Acne is one of the most common skin diseases worldwide and results in major health care costs and significant morbidity to severely affected individuals. However, the pathophysiology of this disorder is not well understood. Host-microbiome interactions that affect both innate and adaptive immune homeostasis appear to be a central factor in this disease, with recent observations suggesting that the composition and activities of the microbiota in acne is perturbed. Read More

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October 2018
4 Reads

Proteomic profile of root canal contents in teeth with post-treatment endodontic disease.

Int Endod J 2018 Oct 4. Epub 2018 Oct 4.

Department of Restorative Dentistry, Endodontic Division, Piracicaba Dental School, State University of Campinas, Piracicaba, São Paulo, Brazil.

Aim: To characterize the proteome of 20 root canals in teeth with post-treatment endodontic disease using mass spectrometry and to correlate the identified proteins with clinical features.

Methodology: Twenty patients with radiographic evidence of apical periodontitis and need for root canal re-treatment were selected. Samples from the root canal contents were collected and processed using two-dimensional capillary nano-flow liquid chromatography and electrospray ionization tandem mass spectrometry. Read More

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October 2018
1 Read

The microbiome of the "sterile" pustules in palmoplantar pustulosis.

Exp Dermatol 2018 Dec;27(12):1372-1377

Department of Dermatology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan.

The skin microbiome influences skin pathophysiology. Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by infectious-like pustules on the palms and soles. These pustules are thought to be sterile because bacterial cultures obtained from the pustules are negative. Read More

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December 2018
1 Read

Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome.

Phytother Res 2018 Dec 3;32(12):2551-2559. Epub 2018 Oct 3.

BK21plus team, College of Pharmacy, The Catholic University of Korea, Bucheon, Korea.

Activation of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome by Propionibacterium acnes (P. acnes) is critical for inducing inflammation and aggravating the development of acne lesions. We searched for available small-molecule inhibitors of the NLRP3 inflammasome that could be topically administered for the treatment of acne. Read More

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December 2018
24 Reads

Microflora of normal maxillary sinuses: does it justify perioperative antibiotic treatment in sinus augmentation procedures.

Clin Oral Investig 2018 Oct 2. Epub 2018 Oct 2.

Department of Otolaryngology-Head & Neck Surgery, Sheba Medical Center, Ramat Gan, Israel.

Objectives: To investigate bacterial flora of normal maxillary sinuses in order to facilitate perioperative antibiotic management in sinus augmentation procedures.

Materials And Methods: Specimens of maxillary sinus mucosa were harvested during planned orthognatic surgery in 18 patients with no evidence of rhinosinusitis. The samples were processed according to hospital routine for aerobic and anaerobic cultures. Read More

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October 2018
3 Reads

The impact of Cymbopogon martinii essential oil on Cutibacterium (formerly Propionibacterium) acnes strains and its interaction with keratinocytes.

J Pharm Pharmacol 2018 Dec 13;70(12):1688-1699. Epub 2018 Sep 13.

Department of Microbiology and Immunology, Institute of Biosciences of Botucatu, UNESP - Campus de Botucatu, Botucatu, SP, Brazil.

Objectives: The human skin microbiota is mainly composed of bacteria belonging to the genera Staphylococcus, Cutibacterium, Micrococcus and Corynebacterium, but on the skin of the face and back, ca. 50% of the total microbiota is represented by the bacterium Cutibacterium acnes. The aim of this research was to evaluate the impact of C. Read More

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December 2018
3 Reads

Low-dose blue light irradiation enhances the antimicrobial activities of curcumin against Propionibacterium acnes.

J Photochem Photobiol B 2018 Dec 26;189:21-28. Epub 2018 Sep 26.

Department of Laboratory Medicine and Biotechnology, Tzu-Chi University, Hualien 970, Taiwan. Electronic address:

Propionibacterium acnes (P. acnes) is an opportunistic infection in human skin that causes acne vulgaris. Antibiotic agents provide the effective eradication of microbes until the development of drug-resistant microbes. Read More

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December 2018
6 Reads

Comparative analyses of biofilm formation among different Cutibacterium acnes isolates.

Int J Med Microbiol 2018 Dec 22;308(8):1027-1035. Epub 2018 Sep 22.

Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010, Graz, Austria; BioTechMed, Graz, Austria. Electronic address:

The Gram-positive anaerobic bacterium Cutibacterium acnes is a commensal of the human skin, but also an opportunistic pathogen that contributes to the pathophysiology of the skin disease acne vulgaris. Moreover, C. acnes, in addition to other skin-colonizing bacteria such as S. Read More

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December 2018
8 Reads