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J Bone Jt Infect 2019 29;4(1):40-49. Epub 2019 Jan 29.

University of California San Francisco, Department of Orthopaedic Surgery.

(formerly ) is a slow growing, gram-positive bacteria that is naturally found in higher concentrations as skin flora on the chest and back, as well as in other areas with greater numbers of hair follicles. Most of the reported cases of shoulder girdle infection follow arthroplasty surgery, which then often requires debridement, administration of intravenous antibiotics, and surgical revision of the implanted device. In a recent study, 56% of 193 shoulder revisions had a positive culture, 70% of which grew . Read More

J Shoulder Elbow Surg 2019 Jan 31. Epub 2019 Jan 31.

Department of Orthopedics, Horsens Regional Hospital, Horsens, Denmark.

Background: Shoulder periprosthetic joint infections (PJI) caused by low-virulent bacteria pose a diagnostic challenge. Combined labeled leukocyte (WBC) and technetium 99m sulfur colloid bone marrow imaging (WBC/BM) is considered the radionuclide imaging gold standard for diagnosing lower limb PJI. However, it is laborious and expensive to perform, and documentation on shoulder arthroplasties is lacking. Read More

Eur Spine J 2019 Feb 2. Epub 2019 Feb 2.

Spine Department, Center for Musculoskeletal Surgery, Charité University Medicine Berlin, Chariteplatz 1, 10117, Berlin, Germany.

Purpose: C-reactive protein (CRP) has been shown to be a powerful parameter for detecting acute postoperative spinal implant infections (PSII) with a high sensitivity and specificity. However, little data are available on the performance of CRP in the diagnosis of delayed PSII. The aim of the current study was therefore to establish cutoff values for diagnosing delayed infection based on serum CRP. Read More

J Urol 2019 Jan 31. Epub 2019 Jan 31.

Purpose: We sought to evaluate the rate of bacterial colonization in artificial urinary sphincters (AUS) during revision surgery for non-infectious etiologies.

Materials And Methods: We evaluated bacterial culture swab data from all explanted AUS components (cuff, pump, and reservoir) in patients undergoing revision surgery between February 2016 and July 2018. Patients undergoing revision for infection or erosion were excluded. Read More

J Shoulder Elbow Surg 2019 Jan 24. Epub 2019 Jan 24.

Bacteriology and Infection Control Unit, Centre Hospitalier Universitaire Nantes, Nantes University Hospital, Nantes, France; Center for Research in Cancerology and Immunology, Univervité de Nantes, Unit 1232, Nantes, France.

Background: The aim of this study was to determine the presence of Cutibacterium acnes (formerly Propionibacterium acnes) on the skin and in deep tissue in a real clinical scenario of primary reverse shoulder arthroplasty.

Methods: This prospective study included 90 primary reverse shoulder arthroplasties, and 12 cultures were obtained from each patient. Each sample was homogenized and used to inoculate PolyVitex (bioMérieux, Marcy-l'Etoile, France) agar and Schaedler (bioMérieux) agar plates. Read More

Int Orthop 2019 Jan 18. Epub 2019 Jan 18.

Department of Trauma and Orthopedic Surgery, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Friedberger Landstr. 430, 60389, Frankfurt am Main, Germany.

Introduction: There is no gold standard for performing a two-stage exchange arthroplasty to treat periprosthetic joint infection (PJI). The use of spacers and the anchorage principles of the revision prosthesis remain controversial. Herein, we report the success rate of a two-stage total hip replacement procedure without using a spacer and only pressfit cementless implants. Read More

Eur Spine J 2019 Jan 17. Epub 2019 Jan 17.

Charité - Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany.

Purpose: In total joint replacement, culturing of the sonication fluid of removed implants has proven to be more sensitive than conventional periprosthetic tissue culture for the microbiological diagnosis of prosthetic joint infection. However, its role in postoperative spinal implant infection (PSII) is not well investigated. Therefore, the aim of this study was to determine the validity of sonication in detecting infection following instrumented spine surgery. Read More

Mucosal Immunol 2019 Mar 15;12(2):434-444. Epub 2019 Jan 15.

Department of Infectious Diseases & Immunology, University of Florida, Gainesville, FL, USA.

Newborns are highly susceptible to pathogenic infections with significant worldwide morbidity possibly due to an immature immune system. Recently, we reported that Propionibacterium strain, P. UF1, isolated from the gut microbiota of preterm infants, induced the differentiation of bacteria-specific Th17 cells. Read More

Diabetes Metab Syndr 2019 Jan - Feb;13(1):414-418. Epub 2018 Oct 13.

Former Professor of Endocrinology and Dean, Faculty of Medicine, Ex-Director, Rajiv Gandhi Centre for Diabetes and Endocrinology, Former Dean, Faculty of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, 202002, India; Consultant, Diabetes and Superspeciality Center, Central Tower Ground Floor, Kela Nagar Chauraha, Aligarh, 202002, India.

Diabetes Mellitus is characterized as a hyperglycemic condition, which results due to alteration in the secretion of insulin or action of insulin. The development and spread of microorganisms is known as a key health concern, and such cases are growing drastically in hospitals and communities. Therefore, the study aims to determine the potential risk factors and infection outcomes among diabetic patients with multi drug resistance, who are suffering from foot ulcerations. Read More

Molecules 2019 Jan 9;24(2). Epub 2019 Jan 9.

Research Centre skinitial, Department of Dermatology, University Medical Center, 79104 Freiburg, Germany.

Acne is associated with hyperkeratosis, elevated levels of skin sebum and growth of () and (). Furthermore, promotes inflammation by inducing IL-6 production and oxidative stress. The aim of this study was to assess the antioxidant, anti-inflammatory and antibacterial potential of a hop-CO₂-extract with 50% humulone and lupulone. Read More

World Neurosurg 2018 Dec 24. Epub 2018 Dec 24.

Department of Neurological Surgery, University Medical Center Mainz, Germany.

Osteonecrosis of bone flaps after cranioplasty with autologeous cryo-conserved bone flaps is a common phenomenon. The exact reason for it remains unknown. We present a case of a 67-year old patient who had a bone flap necrosis after elective craniotomy and underwent secondary cranioplasty. Read More

Biochem Biophys Res Commun 2019 Jan 23;509(1):322-328. Epub 2018 Dec 23.

Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address:

Propionibacterium acnes is an anaerobic gram-positive bacterium found in the niche of the sebaceous glands in the human skin, and is a causal pathogen of inflammatory skin diseases as well as periprosthetic joint infection. To gain effective control of P. acnes, a deeper understanding of the cellular metabolism mechanism involved in its ability to reside in this unique environment is needed. Read More

BMC Musculoskelet Disord 2018 Dec 20;19(1):445. Epub 2018 Dec 20.

Orthopedic Center, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Suzhou, 215000, China.

Background: The existence of latent low-virulence anaerobic bacteria in degenerated intervertebral discs (IVDs) remains controversial. In this study, the prevalence of low-virulence anaerobic bacteria in degenerated IVDs was examined, and the correlation between bacterial infection and clinical symptoms was analysed.

Methods: Eighty patients with disc herniation who underwent discectomy were included in this study. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Intermountain Medical Center, Murray, Utah, USA.

In September 2015, a male aged 61 years with poorly controlled diabetes (his only medical problem) had left shoulder surgery that included an arthroscopic acromioplasty with debridement of suture material from a rotator cuff repair done 10 years prior. A subacromial corticosteroid injection was given 7 months later for pain and reduced motion. Three weeks later a fulminate infection was evident. Read More

J Shoulder Elbow Surg 2019 Jan;28(1):1-8

Department of Orthopaedic Surgery, Rothman Institute-Thomas Jefferson University, Philadelphia, PA, USA.

Background: Serum and synovial markers used to diagnose lower extremity prosthetic joint infection (PJI) have performed poorly for shoulder PJI. As a result, diagnosis is commonly reliant on the accuracy of positive or negative cultures. Next-generation sequencing (NGS) can sequence an entire bacterial genome. Read More

Nat Commun 2018 12 12;9(1):5075. Epub 2018 Dec 12.

Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King's College London, London, SE1 9RT, UK.

Acne vulgaris is a highly heritable common, chronic inflammatory disease of the skin for which five genetic risk loci have so far been identified. Here, we perform a genome-wide association study of 3823 cases and 16,144 controls followed by meta-analysis with summary statistics from a previous study, with a total sample size of 26,722. We identify 20 independent association signals at 15 risk loci, 12 of which have not been previously implicated in the disease. Read More

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. Read More

Microbiol Resour Announc 2018 Jul 19;7(2). Epub 2018 Jul 19.

Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.

Propionibacterium acnes, a non-spore-forming anaerobic Gram-positive bacterium, has been linked to a wide range of opportunistic human infections and conditions, most notably acne vulgaris. Here, we present the draft genome sequence of P. acnes subsp. Read More

J Bone Jt Infect 2018 24;3(5):255-257. Epub 2018 Nov 24.

Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, Nantes, France.

After rifampin and levofloxacin treatment for a bone infection, a pyogenic granuloma due to a newly described species, developed on the tibia former external fixator. This rifampin resistant bacterium, selected during treatment, harbored a mutation in the gene. This case illustrates the possible selection of resistant mutant most likely due to the bacterial burden and therefore the importance of adequate bone infection treatment. Read More

PLoS One 2018 6;13(12):e0208171. Epub 2018 Dec 6.

Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background: Cystic fibrosis (CF) is a disorder affecting the respiratory, digestive, reproductive systems and sweat glands. This lethal hereditary disease has known or suspected links to the dysbiosis gut microbiota. High-throughput meta-omics-based approaches may assist in unveiling this complex network of symbiosis modifications. Read More

Eur Spine J 2018 Dec 1. Epub 2018 Dec 1.

Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.

Purpose: The presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. Read More

Avian Pathol 2018 Nov 30:1-29. Epub 2018 Nov 30.

a Department of Veterinary Sciences , University of Torino , Largo Braccini 2, 10095 Grugliasco (Torino) , Italy.

Macrorhabdus ornithogaster is an opportunistic yeast that colonizes the gastric mucosa of many avian species. Until now, no studies have been focused on about the influence of a gastric infection on the balance of the intestinal microbiota of birds. In this study, 44 fecal samples from individual canaries, with and without M. Read More

PLoS One 2018 29;13(11):e0208144. Epub 2018 Nov 29.

Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.

Most patients with chronic lower back pain (CLBP) exhibit degenerative disc disease. Disc specimens obtained during initial therapeutic discectomies are often infected/colonized with Propionibacterium acnes, a Gram-positive commensal of the human skin. Although pain associated with infection is typically ascribed to the body's inflammatory response, the Gram-positive bacterium Staphylococcus aureus was recently observed to directly activate nociceptors by secreting pore-forming α-hemolysins that disrupt neuronal cell membranes. Read More

J Am Acad Orthop Surg 2018 Nov 13. Epub 2018 Nov 13.

From the Department of Orthopaedic Surgery (Dr. Klement, Dr. Cunningham, Dr. Wooster, Dr. Wellman, Dr. Bolognesi), Duke University Medical Center, and the Department of Biostatistics and Bioinformatics (Dr. Green), Duke University School of Medicine, Durham, NC, and Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL (Dr. Garrigues).

Introduction: Periprosthetic joint infection (PJI) is a devastating complication of hip and knee arthroplasties. Surgical cultures are essential for the diagnosis and treatment of PJI. Yet, the ideal culture duration remains unclear. Read More

Bone Joint J 2018 Nov;100-B(11):1482-1486

Center for Musculoskeletal Surgery, Charité - University Medicine Berlin, Berlin, Germany.

Aims: The aim of this study was to determine the prevalence and characteristics of C-reactive protein (CRP)-negative prosthetic joint infection (PJI) and evaluate the influence of the type of infecting organism on the CRP level.

Patients And Methods: A retrospective analysis of all PJIs affecting the hip or knee that were diagnosed in our institution between March 2013 and December 2016 was performed. A total of 215 patients were included. Read More

Arch Orthop Trauma Surg 2018 Nov 7. Epub 2018 Nov 7.

Division of Orthopaedics and Traumatology, Cantonal Hospital Winterthur, Brauerstrasse 15, P.O. Box 834, 8401, Winterthur, Switzerland.

Introduction: Knitted cotton outer gloves offer protection against surgical glove perforation and provide improved grip on instruments. These gloves absorb blood and other fluids during surgery, and may therefore also accumulate contaminating bacteria. To date, there is no published data on microbial contamination of such gloves during surgery. Read More

Biomed Res Int 2018 14;2018:8509527. Epub 2018 Oct 14.

Surgical Sciences Department, Mauriziano-Umberto I Hospital, University of Torino, 10128 Turin, Italy.

Preoperative skin preparation plays a major role in preventing postoperative infections. This study aims to compare a single skin preparation (povidone iodine) with a double skin preparation (chlorhexidine gluconate followed by povidone iodine). Forty patients affected by proximal humeral fracture were included in the study. Read More

J Mol Med (Berl) 2019 Jan 6;97(1):25-35. Epub 2018 Nov 6.

Department of Orthopedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China.

Latent infection of Propionibacterium acnes was considered as a new pathogeny for low back pain (LBP); however, there is no credible animal evidence or mechanism hypothesis. This study proved that P. acnes is a causative pathogen of bacteria-induced LBP and investigated its underlying mechanism. Read More

PLoS One 2018 5;13(11):e0207016. Epub 2018 Nov 5.

Department of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.

Objective: We investigated the association between bacterial microbiota in breast milk and the infant mouth. The influence of human papilloma virus (HPV) infection on infant oral microbiota was also assessed.

Material And Methods: Altogether 35 breast milk and 35 infant oral samples with known HPV status were selected from the Finnish Family HPV Study cohort. Read More

Eur J Pediatr 2019 Jan 15;178(1):89-95. Epub 2018 Oct 15.

Department of Paediatrics, The University of Melbourne, Parkville, Australia.

Chronic nonbacterial osteomyelitis (CNO) and SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome are auto-inflammatory disorders manifesting as chronic inflammation of bones and joints, which in SAPHO is often accompanying by skin changes. The aetiology of these diseases is unknown, but includes genetic, infectious and immunological components. It has been proposed that Cutibacterium (formerly Propionibacterium) acnes plays a role in the pathogenesis. Read More

ANZ J Surg 2018 Nov 8;88(11):1182-1186. Epub 2018 Oct 8.

Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand.

Background: Traditional skin preparation for shoulder surgery is not specific for Propionibacterium acnes. Topical benzoyl peroxide for 48 h preoperatively has been shown to reduce the bacterial load of P. acnes on the skin. Read More

J Photochem Photobiol B 2018 Dec 26;189:21-28. Epub 2018 Sep 26.

Department of Laboratory Medicine and Biotechnology, Tzu-Chi University, Hualien 970, Taiwan. Electronic address:

Propionibacterium acnes (P. acnes) is an opportunistic infection in human skin that causes acne vulgaris. Antibiotic agents provide the effective eradication of microbes until the development of drug-resistant microbes. Read More

Int J Med Microbiol 2018 Dec 22;308(8):1027-1035. Epub 2018 Sep 22.

Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010, Graz, Austria; BioTechMed, Graz, Austria. Electronic address:

The Gram-positive anaerobic bacterium Cutibacterium acnes is a commensal of the human skin, but also an opportunistic pathogen that contributes to the pathophysiology of the skin disease acne vulgaris. Moreover, C. acnes, in addition to other skin-colonizing bacteria such as S. Read More

Eur J Trauma Emerg Surg 2018 Sep 25. Epub 2018 Sep 25.

Department of Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Center (CMMC), University Witten-Herdecke (UWH), Ostmerheimerstr. 200, 51109, Cologne, Germany.

Purpose: There are several hints that bacterial colonization might be an often overseen cause of non-union. Modern procedures like PCR have been reported to diagnose bacterial colonization with a high degree of accuracy. While PCR is not ubiquitously available, we hypothesize that biopsies from the non-union site are comparable to PCR results reported in the literature. Read More

J Am Acad Orthop Surg 2019 Feb;27(4):136-144

From the Department of Orthopaedics (Dr. Boyle, Mr. Wright, and Dr. Duquin), State University of New York at Buffalo, the Department of Microbiology and Immunology (Dr. Crane), State University of New York at Buffalo, Buffalo, NY, and the Division of Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, New York, NY (Dr. Nodzo).

Introduction: The purpose of this study was to further evaluate the pathogenicity of hemolytic and nonhemolytic phenotypes of Propionibacterium acnes (P acnes) isolates from shoulders of orthopaedic patients.

Methods: Thirty-one patient records were reviewed, which had a positive P acnes shoulder culture from joint aspiration fluid and/or intraoperative tissues for demographics, clinical course, culture, and laboratory data. Patients were categorized as definite infection, probable infection, or probable contaminant. Read More

ANZ J Surg 2018 Nov 21;88(11):1178-1181. Epub 2018 Sep 21.

Department of Upper Limb, Melbourne Orthopaedic Group, Melbourne, Victoria, Australia.

Background: Propionibacterium acnes may be transmitted from the subdermal tissues to the deeper tissues during shoulder arthroplasty surgery, resulting in deep infection. The aim of this prospective, clinical study was to determine whether the use of a wound protector drape can lower the incidence of P. acnes in the wound during shoulder arthroplasty surgery. Read More

BMJ Case Rep 2018 Sep 18;2018. Epub 2018 Sep 18.

ENT, Wexham Park Hospital, Slough, UK.

Reported is the case of a 79-year-old woman initially diagnosed with periorbital abscess on the background of a recent upper respiratory tract infection. Unexpectedly, intraoperative findings were that of a haematoma rather than an abscess. Subperiosteal orbital haematoma (SOH) is an extremely rare complication of rhinosinusitis. Read More

J Obstet Gynaecol Res 2019 Jan 3;45(1):235-238. Epub 2018 Sep 3.

Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan.

Sarcoidosis is a systemic granulomatous disease that is most commonly manifested in the pulmonary system. Though the entire etiology of sarcoidosis remains unknown, it has been reported that Propionibacterium acnes (P. acnes) has been isolated from sarcoid lesions. Read More

J Orthop Case Rep 2018 Mar-Apr;8(2):19-22

Department of Orthopaedics, Rutgers -New Jersey Medical School, Newark, New Jersey.

Introduction: Propionibacterium acnes infection has been more frequently recognized as an important cause of post-operative shoulder infection. Infection by this organism is more frequently seen after total shoulder arthroplasty but can also be seen after an open reduction and internal fixation (ORIF) of the proximal humerus. We present a patient with P. Read More

Front Cell Infect Microbiol 2018 14;8:272. Epub 2018 Aug 14.

Central European Institute of Technology, Masaryk University, Brno, Czechia.

The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. Read More

Sci Rep 2018 Aug 28;8(1):12967. Epub 2018 Aug 28.

Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Optimal antimicrobial treatment of infective endocarditis requires identification and susceptibility patterns of pathogens. Sonication of explanted heart valves could increase the identification and culture of pathogens, as shown in prosthetic joint and pacemaker/ICD infections. We tested 26 explanted heart valves from 20 patients with active definite endocarditis for added diagnostic value of sonication to the standard microbiological workup in a prospective diagnostic proof of concept study. Read More

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of Medicine, New Mexico VA Health Care System, Albuquerque, New Mexico, USA.

A 69-year-old man developed left knee hardware infection after suffering from an infected ingrown toenail. The hardware was removed and he was treated with intravenous vancomycin. Ten days after initiation of vancomycin, he developed severe thrombocytopaenia, epistaxis and petechiae. Read More

PLoS One 2018 27;13(8):e0202933. Epub 2018 Aug 27.

Deparment of Medical Science, College of Medical Science, SoonChunHyang University, Asan, Chungnam, Korea.

In this study, we investigated the anti-microbial, anti-inflammatory, and anti-lipogenic effects of hemp (Cannabis sativa L.) seed hexane extracts, focusing on the Propionibacterium acnes-triggered inflammation and lipogenesis. Hemp seed hexane extracts (HSHE) showed anti-microbial activity against P. Read More

Medicine (Baltimore) 2018 Aug;97(34):e12010

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto.

Surgical site infections (SSIs) increase the risk of mortality, postsurgery, extend hospital stay, and increase the costs of healthcare. Our aim in this study was to evaluate the effectiveness of a multidisciplinary, evidence-based, surveillance program combined with intrawound application of vancomycin in lowering the incidence rate of SSI after spinal surgery with instrumentation.We conducted a retrospective analysis of 637 patients who underwent spinal fusion with instrumentation in our institution at 3 different time periods: prior to our surveillance program (control group), surveillance only (surveillance group 1), and surveillance combined with intrawound vancomycin application (surveillance group 2). Read More

AJNR Am J Neuroradiol 2018 Sep 23;39(9):1764-1767. Epub 2018 Aug 23.

Joint Department of Medical Imaging (K.M.), University Health Network, Toronto, Ontario.

Background And Purpose: Research on the association between in the disc space and type 1 Modic changes in adjacent vertebrae is limited and has produced mixed results. The prevalence of bacteria in intervertebral discs contradicts the prior understanding that skeletal areas in the human anatomy are sterile; yet it opens new treatment possibilities. We investigated the relationship of and type 1 Modic changes in the cervical spine. Read More

J Shoulder Elbow Surg 2018 Oct 20;27(10):e316-e317. Epub 2018 Aug 20.

Department of Orthopaedic Surgery, Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, USA.

PLoS One 2018 20;13(8):e0202639. Epub 2018 Aug 20.

Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Musculoskeletal Surgery (CMSC), Berlin, Germany.

Background: The definition criteria and clinical characteristics of implant-associated infection (IAI) caused by Cutibacterium (formerly Propionibacterium) spp. are poorly known. We analyzed microbiologically proven Cutibacterium orthopedic IAI in a prospective cohort. Read More

World Neurosurg 2018 Nov 13;119:215-219. Epub 2018 Aug 13.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Background: Sellar infections represent less than 1% of all sellar lesions and can be life-threatening. These infections occur de novo in up to 70% of patients or can less commonly develop after surgical treatment of another primary lesion, such as a pituitary adenoma.

Case Description: We report a unique case of a 27-year-old woman with a recurrent pituitary adenoma treated with 2 previous transsphenoidal resections. Read More

Isr Med Assoc J 2018 Jul;20(7):433-437

Department of Infectious Diseases, Emek Medical Center, Afula, Israel.

Background: Skin colonization of microorganisms in blood cultures (BCs) are generally considered clinically non-significant and can be the source of a true infection, particularly in immunosuppressed patients.

Objectives: To study the epidemiology and risk factors for bacteremia caused by contaminants.

Methods: This retrospective, descriptive study is based on adult BCs collected (2004-2013) and categorized as positive (True bacteremia [TrueB] or contamination) or negative. Read More

J Shoulder Elbow Surg 2018 Dec 10;27(12):2175-2182. Epub 2018 Aug 10.

Department of Joint Replacement, General and Rheumatic Orthopaedics, Orthopaedic Clinic Markgröningen gGmbH, Markgröningen, Germany; Orthopaedic Department, University-Hospital Hamburg-Eppendorf, Hamburg, Germany.

Background: Studies on 1-stage exchange in septic shoulder arthroplasty are limited and show a wide variation of treatment strategies. This retrospective study investigated infection-free survival and function of 1-stage exchange of septic shoulder arthroplasty following a standardized treatment algorithm.

Methods: The requirement for 1-stage exchange was an isolated microorganism from synovial fluid aspiration or synovial biopsy with an antibiotic susceptibility profile prior to revision surgery. Read More