151 results match your criteria Proliferative Verrucous Leukoplakia


[To the question of proliferative verrucous leukoplakia malignant potential].

Arkh Patol 2020 ;82(3):13-17

Peoples' Friendship University of Russia(RUDN university), Moscow, Russia.

Aim Of Study: To study of neoplastic transformation of the epithelial cells of the oral mucosa with verrucous hyperortokeratosis, verrucous carcinoma and oral squamous cell carcinoma (OSCC).

Materials And Methods: Oral mucous membrane biopsies of 33 patients with clinical diagnosis of proliferative verrucous leukoplakia were investigated. Histologically in 19 cases (57. Read More

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http://dx.doi.org/10.17116/patol20208203113DOI Listing
January 2020

Malignant transformation of oral proliferative verrucous leukoplakia: a series of 48 patients with suggestions for management.

Int J Oral Maxillofac Surg 2020 Jun 22. Epub 2020 Jun 22.

Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy. Electronic address:

Proliferative verrucous leukoplakia (PVL) is a rare and refractory form of oral mucosal leukoplakia of unknown origin, characterized by high rates of malignant transformation. Different diagnostic criteria, terminologies, and therapeutic approaches have been proposed since the first report in 1985. There remains no general agreement regarding the clinical and histological diagnosis, prevention, and correct management of this disease. Read More

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http://dx.doi.org/10.1016/j.ijom.2020.05.019DOI Listing

World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia and proliferative verrucous leukoplakia-A systematic review of retrospective studies.

Oral Dis 2020 Apr 19. Epub 2020 Apr 19.

Australian Centre for Oral Oncology Research & Education, Perth, WA, Australia.

Objective: To systematically review retrospective studies examining prognostic potentials of candidate biomarkers to stratify malignant progression of oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL).

Materials And Methods: A systematic literature search of PubMed, EMBASE, Evidence-Based Medicine and Web of Science databases targeted literature published through 29 March 2018. Inter-rater agreement was ascertained during title, abstract and full-text reviews. Read More

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http://dx.doi.org/10.1111/odi.13363DOI Listing
April 2020
2.427 Impact Factor

Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis.

Oral Dis 2020 Mar 6. Epub 2020 Mar 6.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Objectives: We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia.

Methods: We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR).

Results: Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22. Read More

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http://dx.doi.org/10.1111/odi.13322DOI Listing

Clinical manifestations of oral proliferative verrucous leukoplakia: A systematic review.

J Oral Pathol Med 2020 May 9;49(5):404-408. Epub 2020 Feb 9.

School of Dentistry, University of Barcelona, Spain/Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, University of Barcelona, Barcelona, Spain.

Objective: The aim of this systematic review was to gather the available evidence about proliferative verrucous leukoplakia. This systematic review was conducted to answer the question: "What are the main clinical features of PVL patients?".

Material And Methods: A systematic review of the literature was done following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements. Read More

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http://dx.doi.org/10.1111/jop.12999DOI Listing

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.

Head Neck 2020 Mar 5;42(3):539-555. Epub 2019 Dec 5.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.

Importance: Potentially malignant disorders of the oral cavity (OPMD) are a heterogeneous group of lesions associated with a variable risk of malignant transformation (MT) to invasive cancer. Leukoplakia (LE), lichen planus (LP), oral lichenoid lesions (OLL), oral erythroplakia (OE), oral submucous fibrosis (OSF), and proliferative verrucous leukoplakia (PVL) are among the most common of these lesions. Oral dysplasia is a mucosal area characterized by cellular and architectural derangement, which may be associated with OPMDs or not. Read More

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http://dx.doi.org/10.1002/hed.26006DOI Listing

Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical Excision.

Case Rep Dent 2019 22;2019:5785060. Epub 2019 Oct 22.

Department of Oral Medicine & Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya 20400, Sri Lanka.

This report describes a case of proliferative verrucous leukoplakia (PVL) of the gingiva with no discernible aetiology, which presented in a 36-year-old female. The initial nonscrapable gingival lesion was treated with CO laser ablation, and the histopathological evaluation was carried out. The presence of koilocytic cells in the superficial epithelium led to immunohistochemical investigations with p16 antibody, which showed strong nuclear positivity and slight cytoplasmic positivity in >50% of the cells with >25% confluency. Read More

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http://dx.doi.org/10.1155/2019/5785060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854949PMC
October 2019

Oral leukoplakia; a proposal for simplification and consistency of the clinical classification and terminology.

Authors:
I van der Waal

Med Oral Patol Oral Cir Bucal 2019 Nov 1;24(6):e799-e803. Epub 2019 Nov 1.

Department of Oral and Maxillofacial Surgery and Oral Pathology VU University Medical Center P.O. Box 7057, 1007 MB Amsterdam, The Netherlands

There is a distinct lack of uniformity in the definitions and clinical terminologies related to oral leukoplakia and leukoplakialike lesions and disorders. Proposals have been put forward to subclassify leukoplakia into a homogeneous and a non-homogeneous type based on color only, being either predominantly white or mixed whiteand-red, respectively, irrespective of the texture of the lesion. In this proposal there is no need anymore to regard the poorly defined proliferative verrucous leukoplakia as a separate entity. Read More

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http://dx.doi.org/10.4317/medoral.23372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901141PMC
November 2019

Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: A literature review and analysis.

Pathol Res Pract 2019 Dec 25;215(12):152670. Epub 2019 Sep 25.

Rambam medical center, Department of pathology, HaAliya HaShniya St 8, Haifa, 3109601, Haifa, Israel; Technion school of medicine, HaAliya HaShniya St 8, Haifa, 3109601, Haifa, Israel.

Objective: Proliferative verrucous leukoplakia is classified as a potentially malignant disorder because of its high rate of malignant transformation. PVL progresses in a series of clinical stages where the early stage represents multiple, multifocal leukoplakias with a high recurrence rate. The intermediate and late stages are clinically exophytic lesion, diagnosed microscopically as verrucous hyperplasia that often progresses into verrucous carcinoma and/or squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.prp.2019.152670DOI Listing
December 2019
1 Read

"SKILL TO KILL" - Oral cancer and potentially premalignant oral epithelial lesions (PPOELs): A survey approach. Emerging of a new system and professionals.

J Oral Maxillofac Pathol 2019 May-Aug;23(2):248-256

Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.

Background: Oral cancer is said to be the 6th most common cancer in men and 12th in women. Potentially malignant disorders/potentially premalignant oral epithelial lesion (PMDs/PPOELs) have shown an increased risk of progressing to cancer. In this regard, lack of awareness about identification of oral PMDs among healthcare providers in general and oral pathologists in particular is said to be responsible for the diagnostic delay. Read More

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http://www.jomfp.in/text.asp?2019/23/2/248/264795
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http://dx.doi.org/10.4103/jomfp.JOMFP_107_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714248PMC
September 2019
3 Reads

Second primary tumors in proliferative verrucous leukoplakia: a series of 33 cases.

Clin Oral Investig 2020 Jun 22;24(6):1963-1969. Epub 2019 Aug 22.

Oral Medicine, Valencia University, Valencia, Spain.

Objectives: To describe the number of second primary malignancies in a series of 33 patients with proliferative verrucous leukoplakia (PVL), detailing the mean time between primary malignancies and their clinical characteristics.

Materials And Methods: Two groups of patients were included in this study: group 1 comprised 33 PVL patients who had developed ≥ 2 oral squamous cell carcinoma (OSCC) and group 2 comprised 48 PVL patients without malignant degeneration. We compared the groups with regard to age, gender, oral location, and number of oral sites affected. Read More

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http://dx.doi.org/10.1007/s00784-019-03059-9DOI Listing
June 2020
4 Reads

Managing Benign and Malignant Oral Lesions with Carbon Dioxide Laser: Indications, Techniques, and Outcomes for Outpatient Surgery.

Surg J (N Y) 2019 Jul 5;5(3):e69-e75. Epub 2019 Aug 5.

Department of Otolaryngology, San Paolo Hospital, University of Milan, Milan, Italy.

 Because of its affinity for water-based tissues, carbon dioxide (CO ) laser has become an instrument of choice for treating oral mucosa conditions, ranging from inflammatory to malignant lesions. The aim of this work is to systematically evaluate the outcomes of laser surgery over a wide range of lesions, while providing a solid and reproducible protocol for CO laser surgery in the outpatient management of oral lesion.  Seventy-eight patients underwent 92 laser outpatient procedures for treatment of a wide range of benign and malignant lesions. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1694735
Publisher Site
http://dx.doi.org/10.1055/s-0039-1694735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682487PMC
July 2019
4 Reads

Oral cancer on the gingiva in patients with proliferative leukoplakia: A study of 30 cases.

J Periodontol 2019 10 27;90(10):1142-1148. Epub 2019 May 27.

Oral Medicine, Valencia University, Valencia, Spain.

Background: Proliferative verrucous leukoplakia, recently coined as proliferative leukoplakia (PL), is associated with a strong tendency to recur after treatment and an elevated rate of malignant transformation. We compared the clinical characteristics of patients with gingival PL with and without progression to oral squamous cell carcinoma.

Methods: The patients were divided into two groups: group 1 included 33 patients with gingival PL that did not progress to cancer, and group 2 included 30 patients with PL who developed malignant transformation during follow-up. Read More

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http://dx.doi.org/10.1002/JPER.18-0620DOI Listing
October 2019
8 Reads

Inter-observer Variability in the Diagnosis of Proliferative Verrucous Leukoplakia: Clinical Implications for Oral and Maxillofacial Surgeon Understanding: A Collaborative Pilot Study.

Head Neck Pathol 2020 Mar 10;14(1):156-165. Epub 2019 Apr 10.

Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, CA, USA.

The use of diverse terminology may lead to inconsistent diagnosis and subsequent mistreatment of lesions within the proliferative verrucous leukoplakia (PVL) spectrum. The objectives of this study were: (a) to measure inter-observer variability between a variety of pathologists diagnosing PVL lesions; and (b) to evaluate the impact of diverse terminologies on understanding, interpretation, and subsequent treatment planning by oral and maxillofacial surgeons (OMFS). Six oral pathologists (OP) and six head and neck pathologists (HNP) reviewed 40 digitally scanned slides of PVL-type lesions. Read More

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http://dx.doi.org/10.1007/s12105-019-01035-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021885PMC
March 2020
13 Reads

Expanded Expression of Toll-Like Receptor 2 in Proliferative Verrucous Leukoplakia.

Head Neck Pathol 2019 Dec 19;13(4):635-642. Epub 2019 Mar 19.

Dental College of Georgia, Augusta University, GC2250 1430 JW Gilbert Dr., Augusta, GA, 30912, USA.

Proliferative verrucous leukoplakia (PVL) is a premalignant condition of the oral mucosa with > 70% chance of progression to squamous cell carcinoma (SCC), while lacking the common risks and behavior seen in non-PVL oral squamous carcinogenesis. PVL follows a multi-stage slow, relentless and usually multifocal expansion of surface epithelial thickening that over time takes on a verrucous architecture, eventually leading to verrucous carcinoma and/or dysplasia followed by "conventional" SCC, a process that takes years and is notoriously difficult to manage. As mucosal surfaces and carcinomas arising at these sites, are colonized by microorganisms, host receptors for microbial products have received attention as potential contributors to carcinogenesis. Read More

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http://dx.doi.org/10.1007/s12105-019-01028-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854203PMC
December 2019
22 Reads

Oral Epithelial Dysplasia and Premalignancy.

Authors:
Sook-Bin Woo

Head Neck Pathol 2019 Sep 18;13(3):423-439. Epub 2019 Mar 18.

Harvard School of Dental Medicine, Boston, MA, USA.

Leukoplakia and erythroplakia are two entities under the moniker of "oral potentially malignant disorders" that are highly associated with the presence of oral epithelial dysplasia (OED) at first biopsy, while lesions of submucous fibrosis develop OED after being present for years. Importantly, traumatic/frictional keratoses are often mistaken clinically for leukoplakia and it is important for the pathologist to recognize and report them as such. The features of OED have been well-described and other architectural features will be discussed here, in particular verrucous and papillary architecture, bulky epithelial proliferation and epithelial atrophy. Read More

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http://dx.doi.org/10.1007/s12105-019-01020-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684678PMC
September 2019
28 Reads

Lichenoid Characteristics in Premalignant Verrucous Lesions and Verrucous Carcinoma of the Oral Cavity.

Head Neck Pathol 2019 Dec 22;13(4):573-579. Epub 2019 Jan 22.

University of Florida, Gainesville, USA.

Verrucous hyperkeratosis (VH), verrucous carcinoma (VC) and the relentless, truly pre-malignant variant proliferative verrucous leukoplakia often exhibit lichenoid histologic features that may create a diagnostic dilemma for pathologists. This study aims to evaluate and categorize the frequency and the histopathologic patterns of lichenoid features seen in these lesions. Following IRB approval, cases of VH and VC from 1994 to 2014 were retrieved from the archives of UF Oral Pathology Biopsy Service. Read More

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http://dx.doi.org/10.1007/s12105-019-01006-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854141PMC
December 2019
10 Reads

Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta-analysis.

Head Neck 2019 05 11;41(5):1499-1507. Epub 2018 Dec 11.

Faculty of Medicine, Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland.

Background: The aim was to update information on oral proliferative verrucous leukoplakia (PVL), a disease of verrucous-like lesions with high risk of malignancy, and its biomarkers.

Methods: A systematic search of literature on PVL and its biomarkers showed 22 biomarkers that were investigated in 19 papers. A meta-analysis was possible for human papillomavirus (HPV), aneuploidy, Ki-67, and p53. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25569
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http://dx.doi.org/10.1002/hed.25569DOI Listing
May 2019
54 Reads

Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

J Am Acad Dermatol 2019 Jul 14;81(1):59-71. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts; US Department of Veteran Affairs, Boston Health Care System, Boston, Massachusetts. Electronic address:

The second article in this continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to appropriately recognize suspicious lesions, determine the need to obtain a biopsy specimen, counsel, and refer patients presenting with premalignant or malignant conditions. Given the higher rates of mortality and morbidity of oral mucosal malignancies because of late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to patients with these neoplasms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183288
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http://dx.doi.org/10.1016/j.jaad.2018.09.060DOI Listing
July 2019
29 Reads

Molecular pathogenesis of proliferative verrucous leukoplakia: a systematic review.

Br J Oral Maxillofac Surg 2018 11 3;56(9):780-785. Epub 2018 Sep 3.

Molecular and Clinical Cancer Medicine Department, University of Liverpool Cancer Research Centre.

Proliferative verrucous leukoplakia (PVL) is a potentially premalignant lesion that undergoes malignant transformation in over 40% of cases. Its clinical homogeneity suggests that a single or a small number of molecular pathogenic pathways may exist. Using the Cochrane protocol for systematic reviews, we have looked at the reported evidence of the molecular aetiology and pathogenesis of PVL and compared it with that of conventional oral epithelial dysplasia (OED). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02664356183028
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http://dx.doi.org/10.1016/j.bjoms.2018.08.010DOI Listing
November 2018
10 Reads

Diode laser surgery in the treatment of oral proliferative verrucous leukoplakia associated with HPV-16 infection.

Maxillofac Plast Reconstr Surg 2018 Dec 30;40(1):16. Epub 2018 Jul 30.

1Maxillo-Facial and Dental Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Department of Biomedical, Surgical, and Dental Sciences, University of Milan, Via Della Commenda 10, 20122 Milan, Italy.

Background: Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder, characterized by multifocal expression, progressive clinical evolution, and a high rate of malignant transformation. Evidence-based information regarding optimal PVL management is lacking, due to the paucity of data. The present report describes a case of PVL associated with HPV-16 infection and epithelial dysplasia treated by diode laser surgery, and the outcome of disease clinical remission over a 2-year follow-up period. Read More

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http://dx.doi.org/10.1186/s40902-018-0156-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064714PMC
December 2018
10 Reads

Oral proliferative verrucous leukoplakia: A challenge for clinical management.

Head Neck 2018 07 13;40(7):1605-1606. Epub 2018 May 13.

Maxillo-Facial and Dental Unit, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1002/hed.25322DOI Listing
July 2018
9 Reads

Potentially malignant disorders revisited-The lichenoid lesion/proliferative verrucous leukoplakia conundrum.

J Oral Pathol Med 2018 Jul 29;47(6):557-565. Epub 2018 Apr 29.

Newcastle University Medicine Malaysia, Iskandar Puteri, Malaysia.

Background: Clinically identifiable potentially malignant disorders (PMD) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL) and proliferative verrucous leukoplakia (PVL) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT).

Methods: A retrospective review of 590 PMD patients treated in Northern England by CO laser surgery between 1996 and 2014 was carried out. Read More

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http://doi.wiley.com/10.1111/jop.12716
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http://dx.doi.org/10.1111/jop.12716DOI Listing
July 2018
48 Reads

Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.

Authors:
Susan Müller

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 06 1;125(6):591-602. Epub 2018 Mar 1.

Emory University School of Medicine, Atlanta Oral Pathology, Decatur, GA, USA. Electronic address:

The term oral potentially malignant disorders (OPMDs) describes a recognizable group of mucosal diseases that have a risk of progressing to squamous cell carcinoma. Oral leukoplakia, the most common OPMD, has a 1% prevalence and reported malignant transformation rates of 2% to 5%. Other OPMDs include erythroplakia, erythroleukoplakia, submucous fibrosis, lesions of reverse smokers, and inherited genetic disorders, such as Fanconi anemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22124403183008
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http://dx.doi.org/10.1016/j.oooo.2018.02.012DOI Listing
June 2018
44 Reads

Proliferative verrucous leukoplakia misdiagnosed as oral leukoplakia.

J Indian Soc Periodontol 2017 Nov-Dec;21(6):499-502

Department of Periodontology, Swami Devi Dyal Dental College and Hospital, Barwala, Haryana, India.

Correct diagnosis of white lesions of the oral cavity is sometimes difficult, because some oral white lesions behave differently and tend to change their appearance with time. Clinicians often wrongly diagnose such lesions as oral leukoplakias and treat simply. Lesions recur and turn malignant. Read More

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http://dx.doi.org/10.4103/jisp.jisp_189_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846249PMC
March 2018
70 Reads

A Retrospective 20-Year Analysis of Proliferative Verrucous Leukoplakia and Its Progression to Malignancy and Association with High-risk Human Papillomavirus.

Head Neck Pathol 2018 Dec 9;12(4):500-510. Epub 2018 Feb 9.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.

Proliferative verrucous leukoplakia (PVL) is defined as an aggressive, relentless and recalcitrant form of leukoplakia that has a high propensity for malignant transformation. The aim of this study was to evaluate the malignant potential of PVL and determine its possible association with high-risk human papillomavirus (HPV). Twenty cases with a clinical and biopsy proven diagnosis of PVL were collected from the University of Florida Oral Medicine clinic database. Read More

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http://dx.doi.org/10.1007/s12105-018-0893-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232220PMC
December 2018
27 Reads

Proliferative leukoplakia: Proposed new clinical diagnostic criteria.

Oral Dis 2018 Jul 2;24(5):749-760. Epub 2018 May 2.

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA, USA.

Objective: We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathological standpoint and suggest an updated classification.

Subjects And Methods: Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathological features and malignant transformation (MT).

Results: There were 42 patients (median age: 69 years [range: 36-88]; 35 females). Read More

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http://dx.doi.org/10.1111/odi.12830DOI Listing
July 2018
8 Reads

Gingival fibroma versus verrucous leukoplakia - A clinical dilemma!!!

J Indian Soc Periodontol 2016 Nov-Dec;20(6):635-637

Department of Periodontics, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India.

Gingival overgrowths found in the oral cavity are mostly due to reactive hyperplasia and rarely depict neoplastic nature. It is a challenge for the clinician to give final diagnoses of gingival overgrowth. Gingiva is a common site for various benign and malignant lesions. Read More

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http://dx.doi.org/10.4103/jisp.jisp_200_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713089PMC
December 2017
18 Reads

[Morphology of non cutaneous head and neck squamous cell carcinoma].

Pathologe 2018 Feb;39(1):3-10

Institut für Pathologie, Universitätsklinikum Erlangen, Erlangen, Deutschland.

Head and neck squamous cell carcinoma (HNSCC) is by far the most frequent malignant tumor in this anatomic region. Today, HNSCC is divided into two morphologically, molecularly and clinically fundamentally different entities: conventional and virus-associated (HPV/EBV) neoplasms. Premalignant lesions of nonvirus-associated HNSCC include conventional leukoplakia, dysplasia and proliferative verrucous hyperplasia with an increasing risk for malignant transformation. Read More

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http://dx.doi.org/10.1007/s00292-017-0395-5DOI Listing
February 2018
9 Reads

Oral leukoplakia and proliferative verrucous leukoplakia: a review for dental practitioners.

Authors:
K Staines H Rogers

Br Dent J 2017 Dec 3;223(9):655-661. Epub 2017 Nov 3.

Oral Medicine, Bristol Dental Hospital and School, Lower Maudlin Street, Bristol, BS1 2LY, United Kingdom.

Objectives To provide an overview of the current thinking in terms of the diagnosis and management of oral leukoplakia and proliferative verrucous leukoplakia as relevant to general dental practitioners.Data sources, data selection, data extraction, data synthesis We searched the MEDLINE Ovid, EMBASE databases and the Cochrane Library, (1990 to 16 April 2017), restricting our search to English language with the following key words: leukoplakia, white patch, proliferative verrucous leukoplakia, precancerous lesion, premalignant lesions, potentially malignant oral conditions and potentially malignant oral disorders. The two authors selected key papers and engaged in collaborative data extraction and synthesis of the selected reference material. Read More

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http://dx.doi.org/10.1038/sj.bdj.2017.881DOI Listing
December 2017
15 Reads

An unusual case report of an early proliferative verrucous leukoplakia.

Int J Clin Exp Pathol 2017 1;10(11):11276-11280. Epub 2017 Nov 1.

Department of Oral Pathology, Stomatological Hospital, Southern Medical University Guangzhou 510280, Guangdong, China.

Proliferative verrucous leukoplakia (PVL) is a very rare kind of leukoplakia with great risk of cancerization. The previously reported PVL are mostly elderly patients with a longer progress. We received one rare case of an early PVL patient. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965850PMC
November 2017

Treatment resistance in potentially malignant disorders-'Nature' or 'Nurture'…?

J Oral Pathol Med 2017 Nov 18;46(10):902-910. Epub 2017 Sep 18.

Newcastle University Medicine Malaysia, Iskandar Puteri, Malaysia.

Background: Contemporary potentially malignant disorder management is based upon provisional histological diagnosis followed by interventional surgery to excise or ablate 'high-risk' mucosal lesions. Although the majority of patients achieve disease-free status post-treatment, others develop further or persistent disease unresponsive to intervention.

Methods: A detailed, retrospective clinico-pathological review of treatment resistant potentially malignant lesions, from a 590 patient cohort treated by CO laser surgery and followed for a mean of 7. Read More

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http://dx.doi.org/10.1111/jop.12641DOI Listing
November 2017
45 Reads

CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.

Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.

"M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.

Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

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http://clinicalepigeneticsjournal.biomedcentral.com/articles
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http://dx.doi.org/10.1186/s13148-017-0386-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558660PMC
May 2018
22 Reads

Management of proliferative verrucous leukoplakia: Justification for a conservative approach.

Head Neck 2017 10 22;39(10):1997-2003. Epub 2017 Jun 22.

Mersey Head and Neck Oncology Research Group (MHNORG), Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

Background: Proliferative verrucous leukoplakia (PVL) is a progressive, multifocal, exophytic form of leukoplakia with high rates of malignant transformation. The purpose of this study was to evaluate a cohort of patients with PVL in a single tertiary referral clinic.

Method: Cases meeting accepted diagnostic criteria were reviewed with regard to their pathology, demographic characteristics, management, and outcomes. Read More

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http://dx.doi.org/10.1002/hed.24845DOI Listing
October 2017
77 Reads

Proliferative verrucous leukoplakia of the tongue.

Med Clin (Barc) 2018 01 14;150(2):84. Epub 2017 Apr 14.

Servicio de Cirugía Oral y Maxilofacial, Hospital Universitario Virgen de las Nieves, Granada, España.

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http://dx.doi.org/10.1016/j.medcli.2017.03.010DOI Listing
January 2018
11 Reads

Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue.

Authors:
Susan Müller

Head Neck Pathol 2017 Mar 28;11(1):33-40. Epub 2017 Feb 28.

Emory University School of Medicine, Atlanta Oral Pathology, 2701 N. Decatur Road, Decatur, GA, 30033, USA.

There have been several additions and deletions in Chapter 4 on Tumours of the oral cavity and mobile tongue in the 2017 fourth edition of the World Health Organization Classification of Tumours of the Head and Neck. This chapter excludes the oropharynx, which now is a stand-alone chapter acknowledging the uniqueness of the oropharynx from the oral cavity. New entries in Chapter 4 include rhabdomyoma, haemangioma, schwannoma, neurofibroma and myofibroblastic sarcoma in the section titled Soft tissue and neural tumours. Read More

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http://dx.doi.org/10.1007/s12105-017-0792-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340733PMC
March 2017
20 Reads

Proliferative verrucous leukoplakia: diagnosis, management and current advances.

Braz J Otorhinolaryngol 2017 Sep - Oct;83(5):585-593. Epub 2017 Jan 24.

Universidade Federal de Santa Catarina (UFSC), Departamento de Patologia, Florianopolis, SC, Brazil. Electronic address:

Introduction: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.

Objective: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update. Read More

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http://dx.doi.org/10.1016/j.bjorl.2016.12.005DOI Listing
December 2017
13 Reads

Letter to the Editor: Development of proliferative verrucous leukoplakia (PVL) in oral lichen planus: Is it not a clinical spectrum of PVL?

Med Oral Patol Oral Cir Bucal 2017 03 1;22(2):e142-e143. Epub 2017 Mar 1.

Faculdade de Odontologia de Piracicaba - UNICAMP, Departamento de Diagnóstico Oral - Semiologia, Av. Limeira, 901 CEP 13.414-903, Piracicaba - São Paulo - Brasil,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359711PMC
http://dx.doi.org/10.4317/medoral.21605DOI Listing
March 2017
8 Reads

Oral lichenoid lesions: distinguishing the benign from the deadly.

Authors:
Susan Müller

Mod Pathol 2017 01;30(s1):S54-S67

Professor Emeritus, Emory University School of Medicine: Atlanta Oral Pathology, Decatur, GA, USA.

Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus. Read More

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http://www.nature.com/articles/modpathol2016121
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http://dx.doi.org/10.1038/modpathol.2016.121DOI Listing
January 2017
20 Reads

[Precancerous lesions of the buccal epithelium].

Ann Dermatol Venereol 2017 Feb 6;144(2):100-108. Epub 2016 Dec 6.

Service de pathologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.

Squamous cell carcinomas of the oral cavity and lips consistently have a high incidence (they constitute the fifth most common form of cancer in France) and carry a heavy prognosis, particularly if diagnosed late. According to different studies, between 10 and 80% of such carcinomas occur in a pre-existing or precancerous lesion. The World Health Organisation (WHO) recommends the use of two terms for such lesions: precursor lesions, i. Read More

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http://dx.doi.org/10.1016/j.annder.2016.07.017DOI Listing
February 2017
15 Reads

Low expression of angiotensinogen and dipeptidyl peptidase 1 in saliva of patients with proliferative verrucous leukoplakia.

World J Clin Cases 2016 Nov;4(11):356-363

Isadora Luana Flores, Alan Roger Santos-Silva, Ricardo Della Coletta, Marcio Ajudarte Lopes, Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil.

Aim: To elucidate the profile of the salivary proteome.

Methods: Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia (PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach, followed by analyses of variance and logistic regression tests.

Results: A total of two hundred and eighty-three proteins were confidently identified in saliva. Read More

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http://dx.doi.org/10.12998/wjcc.v4.i11.356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112355PMC
November 2016
12 Reads

Proliferative Verrucous Leukoplakia - A Perpetuating Ambiguity.

J Clin Diagn Res 2016 Oct 1;10(10):ZL01. Epub 2016 Oct 1.

Reader, Department of Oral Pathology, Maharaja Ganga Singh Dental College and Research Centre , Shri Ganganagar, Rajasthan, India .

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http://dx.doi.org/10.7860/JCDR/2016/21588.8659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121833PMC
October 2016
8 Reads

Interventional laser surgery for oral potentially malignant disorders: a longitudinal patient cohort study.

Int J Oral Maxillofac Surg 2017 Mar 17;46(3):337-342. Epub 2016 Nov 17.

Department for Health, University of Bath, Bath, Somerset, UK.

Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Read More

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http://dx.doi.org/10.1016/j.ijom.2016.11.001DOI Listing
March 2017
42 Reads

Exophytic Verrucous Hyperplasia of the Oral Cavity – Application of Standardized Criteria for Diagnosis from a Consensus Report

Asian Pac J Cancer Prev 2016 01;17(9):4491

Stomatology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia

Verruco-papillary lesions (VPLs) of the oral cavity described in the literature involve a spectrum of conditions including squamous papilloma, verruca vulgaris, focal epithelial hyperplasia, condyloma, proliferative verrucous leukoplakia and verrucous carcinoma. A majority of the VPLs are slow growing, benign in nature and have a viral aetiology. Virus associated benign mucosal outgrowths are not too difficult to diagnose either clinically or by microscopy. Read More

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http://dx.doi.org/10.7314/APJCP.2016.17.(9).4491DOI Listing
January 2016
62 Reads

Cancer-associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia-associated squamous cell carcinoma.

J Oral Pathol Med 2017 May 15;46(5):353-358. Epub 2016 Oct 15.

Department of Pathology, Rambam Medical Center, Bat Galim, Haifa, Israel.

Background: Cancer-associated fibroblasts (CAFs) are generally associated with negative prognostic factors. This study compares the clinicopathologic impact of CAFs in oral squamous cell carcinoma in patients with a history of proliferative verrucous leukoplakia (p-scca) and patients with conventional squamous cell carcinoma of the buccal mucosa, gingiva, and palate (c-scca).

Methods: A retrospective clinicopathologic and immunohistochemical analysis of 97 tumor specimens from 78 patients (13 patients with proliferative verrucous leukoplakia-associated squamous cell carcinoma (n = 32) and conventional squamous cell carcinoma from the buccal mucosa, gingiva, and palate (n = 65) was conducted. Read More

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http://dx.doi.org/10.1111/jop.12503DOI Listing
May 2017
24 Reads

A proteomic approach to compare saliva from individuals with and without oral leukoplakia.

J Proteomics 2017 01 29;151:43-52. Epub 2016 Jul 29.

Oral Pathology, Federal Fluminense University (UFF), R. Marques de Paraná, 303/4° andar (Hospital Universitário Antônio Pedro), Centro Niterói, Brazil, CEP: 24033-900. Electronic address:

Background: Oral leukoplakia is the most common potentially malignant disorder in the oral cavity and can precede carcinoma. This study aimed to identify possible oral leukoplakia salivary biomarkers.

Methods: Unstimulated saliva was collected from participants and protein concentration was determined. Read More

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http://dx.doi.org/10.1016/j.jprot.2016.07.029DOI Listing
January 2017
51 Reads

Proliferative verrucous leukoplakia: An update.

J Cancer Res Ther 2016 Apr-Jun;12(2):469-73

Department of Pathology, Rural Medical College, Pravara Institute of Medical Sciences, Loni, Maharashtra, India.

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behavior due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in elderly women, over 60 years at the time of diagnosis. Read More

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http://dx.doi.org/10.4103/0973-1482.151443DOI Listing
March 2017
7 Reads

Diode laser: In treatment of recurrent verrucous leukoplakia.

Contemp Clin Dent 2016 Apr-Jun;7(2):250-4

Department of Oral Medicine and Radiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.

Laser first came into light in 1960 and had been used extensively in various fields of medicine. Laser has been experimented in the various dental field, and its utility is being recognized and established well in the dentistry. Lasers are widely used for a number of procedures such as cavity preparation, scaling, and root planning, surgical procedures like excision of soft tissue growths, etc. Read More

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http://dx.doi.org/10.4103/0976-237X.183043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906875PMC
June 2016
16 Reads