52 results match your criteria Proliferating Pilar Tumor


Proliferating Pilar Tumors: Can Immunohistochemistry Differentiate Benign and Malignant Forms?

Am J Dermatopathol 2021 Mar;43(3):198-201

Department of Pathology, Acibadem University, School of Medicine, Istanbul, Turkey.

Background: Proliferating pilar tumor (PPT) is an adnexal tumor of purported differentiation toward the follicular outer root sheath. Immunohistochemistry has been suggested to differentiate between benign and malignant forms.

Methods: Eleven benign (PPT) and 9 malignant PPT lesions were reviewed; Ki67, p27, and p53 were applied. Read More

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Proliferating pilar tumor: a rare cutaneous entity mimicking breast malignancy on imaging.

Breast J 2020 06 6;26(6):1251-1252. Epub 2020 Jan 6.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

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Management of 3 Proliferating Pilar Tumors: Definition, Differential Diagnosis, and Treatment Options.

Actas Dermosifiliogr 2019 Dec 28;110(10):850-854. Epub 2019 May 28.

Patología, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia.

A proliferating pilar tumor is a rare skin neoplasm that arises from the outer root sheath of a hair follicle. Presentation varies widely, as the tumor can be benign or malignant and has a high probability of recurring after excision. We report our experience managing 3 proliferating pilar tumors with different clinical presentations and pathology findings at Hospital de San José, Bogota, Colombia. Read More

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December 2019

Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation.

Am J Dermatopathol 2019 Nov;41(11):810-818

CellCOM-SB Research Group Department, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain.

Introduction: Benign cutaneous tumors with follicular differentiation are alleged to differentiate toward parts of the hair follicle. Connexin 43 (Cx43) is a gap junction protein, the tumoral role of which has been investigated in several types of tumors.

Objective: To study the pattern of expression of Cx43 in benign cutaneous tumors with follicular differentiation and to compare it with that shown by their alleged anatomical counterparts of the hair follicle. Read More

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November 2019

Malignant Proliferating Trichilemmal Tumor Treated with Radical Radiotherapy: A Case Report and Literature Review.

Cureus 2017 Jan 26;9(1):e999. Epub 2017 Jan 26.

Department of Radiation Oncology, London Regional Cancer Program, Western University, London, Ontario, CA ; Schulich School of Medicine & Dentistry, Western University, London, Ontario, CA.

Reported here is the first case of a malignant proliferating trichilemmal tumor treated with radical radiotherapy. Complete clinical response was achieved, and this obviated the need for aggressive surgery. These tumors have a tendency to develop in older patients, and have a propensity for affecting women more than men. Read More

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January 2017

Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis-a Case Report.

Indian J Surg 2016 Dec 15;78(6):493-495. Epub 2016 Jan 15.

Department of Surgery, K S Hegde Medical Academy, Mangalore, India.

Malignant proliferating trichilemmal tumour (MPTT) is a rare cutaneous tumour predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumours are largely benign, often cystic and are characterized by trichilemmal keratinisation. Read More

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December 2016

Extensive and ulcerated malignant proliferating trichilemmal (pilar) tumour, arising from multiple, large, degenerated trichilemmal (pilar) cysts.

BMJ Case Rep 2016 Feb 8;2016. Epub 2016 Feb 8.

Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Algarve, Portugal.

We report a rare case of a 61-year-old homeless man with a 15-year history of multiple trichilemmal cysts that served as a forerunner for the emergence of a malignant proliferating pilar tumour. The patient presented multiple, large, purulent, ulcerated lesions ranging from 10 to 150 mm in diameter, covering most of the scalp, with large areas superimposed by extensive myiasis infestation. The patient presented with no other major clinical findings. Read More

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February 2016

Benign follicular tumors.

An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8

Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.

Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these lesions be multiple and represent a cutaneous marker of complex syndromes associated with an increased risk of visceral neoplasms. Read More

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Recurrent proliferating trichilemmal cyst of the scalp.

G Ital Dermatol Venereol 2018 Feb 1;153(1):107-110. Epub 2015 Oct 1.

Department of Surgery, Ivrea-Cuorgné Hospital, Ivrea, Italy.

Pilar tumors, commonly called trichilemmal cysts, are usually benign in nature, malignant transformation (so called proliferating pilar tumors or proliferating trichilemmal cysts [PTCs]) with high recurrence rates, local invasion and metastases have been described. A 64-year-old women presented to our hospital with a recurrent ulcerated mass lesion of the scalp. Non-contrast-enhanced computed tomography scan of the head was performed. Read More

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February 2018

Proliferating Pilar Tumor of Scalp Metastasizing to Pancreas: Diagnosis With Endoscopic Ultrasound-guided Fine-needle Aspiration.

Clin Gastroenterol Hepatol 2015 Nov 30;13(11):e164-5. Epub 2015 Apr 30.

Division of Gastroenterology, VA Medical Center, Minneapolis, Minnesota.

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November 2015

Recurrent malignant proliferating trichilemmal tumor with lymph node metastasis in a young woman.

J Postgrad Med 2014 Oct-Dec;60(4):400-2

Department of General Surgery, Padmashree Dr. DY Patil Medical College, Hospital and Research Center, Dr. DY Patil Vidyapeeth, Pune, Maharashtra, India.

Malignant proliferating trichilemmal tumor (MPTT) is a rare cutaneous tumor predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumors are largely benign, often cystic, and are characterized by trichilemmal keratinization. Read More

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[Facultative furuncular myiasis type of dyptera zoonosis over malignant pilar proliferating tumor: a single case].

Rev Esp Quimioter 2014 Sep;27(3):217-9

Jose Joaquín Hernández Roca, Hospital Universitário Rafael Méndez. Carretera de Granada, s/n, 30800, Lorca (Murcia), Spain.

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September 2014

Trichilemmal cyst of the third fingertip: a case report.

Hand Surg 2014 ;19(1):131-3

Plastic and Reconstructive Surgery, Sanliurfa Training Hospital, Sanliurfa, Turkey.

Introduction: Trichilemmal cysts (TCs) are common skin lesions that occur in hairy areas. A TC involving a fingertip has not been previously described in the literature. We herein report a case of a TC occupying a fingertip region. Read More

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November 2014

Proliferating trichilemmal cyst: the value of ki67 immunostaining.

Int J Trichology 2013 Jul;5(3):115-7

Division of Investigation, General Hospital "Dr. Manuel Gea González", Calz. Tlalpan 4800, Seccion VX, C.P 14000, México.

Background: A proliferating trichilemmal cyst (PTC) is an uncommon, rapidly-reproducing cutaneous epithelial cyst, differentiating from the isthmic portion of the outer hair root sheath. It is usually described as a benign tumor, but malignant transformation has been reported and is then denominated as a malignant proliferating trichilemmal tumor. Ki67 immunostaining has been used as a methodology for the evaluation of tumor grade in other tumors, due to its distinctive reaction patterns which exclusively involve proliferating cells. Read More

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Morphological spectrum of pilar cysts.

N Am J Med Sci 2013 Feb;5(2):124-8

Department of Pathology, P.E.S Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India.

Background: Cysts of the skin are one of the commonly excised specimens in the surgical outpatient department. A majority of them being clinically diagnosed as sebaceous cysts, their true nature is only discernible on histopathological examination. Closer examination of the type of keratinization involved will throw light into the exact nature of the cyst. Read More

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February 2013

Trichilemmal pilar tumor of the scalp: a case report.

Gulf J Oncolog 2012 Jul(12):62-4

Radiation Oncology Department, Kuwait Cancer Control Center, Kuwait.

Proliferating trichilemmal tumors (PTTs) are uncommon exuberant growths of cells derived from the external root sheath. They tend to occur in older women, with a predilection for the scalp. Wide local excision has been the standard treatment. Read More

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Proliferating pilar tumor of the scalp.

Dermatol Surg 2012 Aug 15;38(8):1375-7. Epub 2012 May 15.

Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, East Brunswick, New Jersey, USA.

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Complex adnexal tumours of the skin: a report of three cases and review of literature.

J Clin Pathol 2012 Sep 3;65(9):819-22. Epub 2012 May 3.

Department of Dermatology, University of Southern California-Keck School of Medicine, Los Angeles, California, USA.

Aims: Complex or composite adnexal tumours of the skin (CATS) are unusual neoplasms composed of two or more histopathologically distinct subtypes of appendageal neoplasms coexisting in a single cutaneous lesion. The authors report three examples of CATS, review literature and discuss their probable histogenesis.

Methods And Results: Of the three tumours described, one tumour showed a mixture of a proliferating pilar tumour and syringocystadenoma papilliferum, the second lesion was composed of a proliferating pilar tumour and tubulopapillary hidradenoma and the third tumour exhibited a syringocystadenoma papilliferum and tubulopapillary hidradenoma in combination. Read More

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September 2012

Immunohistochemical study of calretinin in normal skin and cutaneous adnexal proliferations.

Am J Dermatopathol 2012 Jul;34(5):491-505

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Avanida Reyes Católicos 2, Madrid, Spain.

Calretinin is a calcium-binding protein member of the EF-hand family. The presence of calretinin has been demonstrated in certain stages of the cellular cycle in a wide variety of normal and neoplastic tissues. The main aims of our study were (1) to investigate what structures of the normal skin and cutaneous adnexal proliferations express immunoreactivity for calretinin and (2) to determine the value of immunohistochemical expression for calretinin as a marker for follicular, sebaceous, apocrine, and eccrine differentiation in cutaneous adnexal proliferations. Read More

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Low-grade malignant proliferating pilar tumor simulating a squamous-cell carcinoma in an elderly female: a case report and immunohistochemical study.

Int J Trichology 2011 Jul;3(2):98-101

Department of Pathology, Smt. Kashibai Navale Medical College & General Hospital, Narhe, Pune, Maharashtra, India.

A 65-year-old lady presented with an ulcerated lesion over the occipital region of nine-year duration, an incisional biopsy of which was reported as squamous-cell carcinoma. A wide local excision was performed and the tissue was sent for histopathological examination which revealed a low-grade malignant pilar tumor. Focal invasion and atypia were noted. Read More

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Proliferating tricholemmal tumour: clinicopathological aspects of a case.

Singapore Med J 2011 Dec;52(12):e255-7

Sindh Medical College, Dow University of Health Sciences, Baba-E-Urdu Road, Karachi 74200, Pakistan.

We report the case of a 49-year-old man who presented with an enlarging mass over his occipital scalp. The clinical impression was either a squamous cell carcinoma or an unusual adnexal tumour. A wide excision was performed with skin grafting. Read More

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December 2011

Posttraumatic giant proliferating trichilemmal cysts on the parietal region of the scalp.

Indian J Dermatol Venereol Leprol 2011 Nov-Dec;77(6):707-9

Department of Pathology, Reconstructive and Esthetic Surgery, Duzce University of Medical Faculty, Duzce, 81000, Turkey.

Proliferating trichilemmal (pilar) cysts, also known as pilar tumors, are most commonly found on the scalp of elderly women. Proliferating trichilemmal cysts are rare, slowly growing, lobular masses inherited autosomal dominantly and localized on scalps, and believed to arise due to a complication of a trauma and inflammation, and 5-10% of people are reported to be effected. Herein, we present the case of a 70-year-old woman with a 23-year history of multiple enlarging scalp masses. Read More

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February 2012

Giant trichilemmal cyst at the neck region.

J Craniofac Surg 2009 May;20(3):961-2

Otorhinolaryngology Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

Trichilemmal cyst (TC) is an adnexal skin tumor that usually occurs on the scalp. There is a female dominance in this tumor. Proliferating pilar tumors or cysts arise from this lesion, and the clinical differential diagnosis from TCs must be taken because of aggressive behavior of proliferating pilar tumor. Read More

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Malignant proliferating pilar tumors arising in KID syndrome: a report of two patients.

Am J Med Genet A 2007 Apr;143A(7):734-41

Department of Otolaryngology, Head and Neck Surgery, Kaiser Permanente, Oakland, CA, USA.

We report on two young adults with KID syndrome and follicular hyperkeratosis, hidradenitis suppurativa of the groin, progressive development of proliferative pilar cysts and dissecting cellulitis of the scalp, who developed metastatic malignant pilar tumors. Based on our findings, we believe that cancer surveillance in patients with KID syndrome should include screening for pilar tumors and their early removal to avoid development of malignant proliferating pilar tumors with poor prognosis. Read More

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Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two.

J Cutan Pathol 2006 Apr;33(4):261-79

Department of Pathology, Stanford University, Palo Alto, CA 94305, USA.

Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential. However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC. No definitive, comprehensive clinicopathological system dividing cutaneous SCCs into categories based upon their aggressiveness has yet been promulgated. Read More

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Proliferating trichilemmal cysts of the scalp on CT.

AJNR Am J Neuroradiol 2006 Mar;27(3):712-4

Department of Radiology, University of South Florida College of Medicine, Tampa, Fla, USA.

Proliferating trichilemmal cysts, also known as pilar tumors, are slow-growing lobulated masses most commonly found on the scalp of elderly women. We present the case of a 69-year-old woman with a 25-year history of multiple enlarging scalp masses. The patient was evaluated for surgical consultation after the dominant mass presented with malignant degeneration. Read More

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Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.

J Cutan Pathol 2006 Mar;33(3):191-206

Department of Pathology, Stanford University, Palo Alto, CA 94305, USA.

Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential. However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC. No definitive, comprehensive clinicopathological system dividing cutaneous SCCs into categories based upon their aggressiveness has yet been promulgated. Read More

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