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    46 results match your criteria Proliferating Pilar Tumor

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    Malignant Proliferating Trichilemmal Tumor Treated with Radical Radiotherapy: A Case Report and Literature Review.
    Cureus 2017 Jan 26;9(1):e999. Epub 2017 Jan 26.
    Department of Radiation Oncology, London Regional Cancer Program, Western University, London, Ontario, CA ; Schulich School of Medicine & Dentistry, Western University, London, Ontario, CA.
    Reported here is the first case of a malignant proliferating trichilemmal tumor treated with radical radiotherapy. Complete clinical response was achieved, and this obviated the need for aggressive surgery. These tumors have a tendency to develop in older patients, and have a propensity for affecting women more than men. Read More

    Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis-a Case Report.
    Indian J Surg 2016 Dec 15;78(6):493-495. Epub 2016 Jan 15.
    Department of Surgery, K S Hegde Medical Academy, Mangalore, India.
    Malignant proliferating trichilemmal tumour (MPTT) is a rare cutaneous tumour predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumours are largely benign, often cystic and are characterized by trichilemmal keratinisation. Read More

    Extensive and ulcerated malignant proliferating trichilemmal (pilar) tumour, arising from multiple, large, degenerated trichilemmal (pilar) cysts.
    BMJ Case Rep 2016 Feb 8;2016. Epub 2016 Feb 8.
    Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Algarve, Portugal.
    We report a rare case of a 61-year-old homeless man with a 15-year history of multiple trichilemmal cysts that served as a forerunner for the emergence of a malignant proliferating pilar tumour. The patient presented multiple, large, purulent, ulcerated lesions ranging from 10 to 150 mm in diameter, covering most of the scalp, with large areas superimposed by extensive myiasis infestation. The patient presented with no other major clinical findings. Read More

    Benign follicular tumors.
    An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8
    Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.
    Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these lesions be multiple and represent a cutaneous marker of complex syndromes associated with an increased risk of visceral neoplasms. Read More

    Recurrent malignant proliferating trichilemmal tumor with lymph node metastasis in a young woman.
    J Postgrad Med 2014 Oct-Dec;60(4):400-2
    Department of General Surgery, Padmashree Dr. DY Patil Medical College, Hospital and Research Center, Dr. DY Patil Vidyapeeth, Pune, Maharashtra, India.
    Malignant proliferating trichilemmal tumor (MPTT) is a rare cutaneous tumor predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumors are largely benign, often cystic, and are characterized by trichilemmal keratinization. Read More

    Trichilemmal cyst of the third fingertip: a case report.
    Hand Surg 2014 ;19(1):131-3
    Plastic and Reconstructive Surgery, Sanliurfa Training Hospital, Sanliurfa, Turkey.
    Introduction: Trichilemmal cysts (TCs) are common skin lesions that occur in hairy areas. A TC involving a fingertip has not been previously described in the literature. We herein report a case of a TC occupying a fingertip region. Read More

    Proliferating trichilemmal cyst: the value of ki67 immunostaining.
    Int J Trichology 2013 Jul;5(3):115-7
    Division of Investigation, General Hospital "Dr. Manuel Gea González", Calz. Tlalpan 4800, Seccion VX, C.P 14000, México.
    Background: A proliferating trichilemmal cyst (PTC) is an uncommon, rapidly-reproducing cutaneous epithelial cyst, differentiating from the isthmic portion of the outer hair root sheath. It is usually described as a benign tumor, but malignant transformation has been reported and is then denominated as a malignant proliferating trichilemmal tumor. Ki67 immunostaining has been used as a methodology for the evaluation of tumor grade in other tumors, due to its distinctive reaction patterns which exclusively involve proliferating cells. Read More

    Morphological spectrum of pilar cysts.
    N Am J Med Sci 2013 Feb;5(2):124-8
    Department of Pathology, P.E.S Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India.
    Background: Cysts of the skin are one of the commonly excised specimens in the surgical outpatient department. A majority of them being clinically diagnosed as sebaceous cysts, their true nature is only discernible on histopathological examination. Closer examination of the type of keratinization involved will throw light into the exact nature of the cyst. Read More

    Trichilemmal pilar tumor of the scalp: a case report.
    Gulf J Oncolog 2012 Jul(12):62-4
    Radiation Oncology Department, Kuwait Cancer Control Center, Kuwait.
    Proliferating trichilemmal tumors (PTTs) are uncommon exuberant growths of cells derived from the external root sheath. They tend to occur in older women, with a predilection for the scalp. Wide local excision has been the standard treatment. Read More

    Complex adnexal tumours of the skin: a report of three cases and review of literature.
    J Clin Pathol 2012 Sep 3;65(9):819-22. Epub 2012 May 3.
    Department of Dermatology, University of Southern California-Keck School of Medicine, Los Angeles, California, USA.
    Aims: Complex or composite adnexal tumours of the skin (CATS) are unusual neoplasms composed of two or more histopathologically distinct subtypes of appendageal neoplasms coexisting in a single cutaneous lesion. The authors report three examples of CATS, review literature and discuss their probable histogenesis.

    Methods And Results: Of the three tumours described, one tumour showed a mixture of a proliferating pilar tumour and syringocystadenoma papilliferum, the second lesion was composed of a proliferating pilar tumour and tubulopapillary hidradenoma and the third tumour exhibited a syringocystadenoma papilliferum and tubulopapillary hidradenoma in combination. Read More

    Immunohistochemical study of calretinin in normal skin and cutaneous adnexal proliferations.
    Am J Dermatopathol 2012 Jul;34(5):491-505
    Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Avanida Reyes Católicos 2, Madrid, Spain.
    Calretinin is a calcium-binding protein member of the EF-hand family. The presence of calretinin has been demonstrated in certain stages of the cellular cycle in a wide variety of normal and neoplastic tissues. The main aims of our study were (1) to investigate what structures of the normal skin and cutaneous adnexal proliferations express immunoreactivity for calretinin and (2) to determine the value of immunohistochemical expression for calretinin as a marker for follicular, sebaceous, apocrine, and eccrine differentiation in cutaneous adnexal proliferations. Read More

    Low-grade malignant proliferating pilar tumor simulating a squamous-cell carcinoma in an elderly female: a case report and immunohistochemical study.
    Int J Trichology 2011 Jul;3(2):98-101
    Department of Pathology, Smt. Kashibai Navale Medical College & General Hospital, Narhe, Pune, Maharashtra, India.
    A 65-year-old lady presented with an ulcerated lesion over the occipital region of nine-year duration, an incisional biopsy of which was reported as squamous-cell carcinoma. A wide local excision was performed and the tissue was sent for histopathological examination which revealed a low-grade malignant pilar tumor. Focal invasion and atypia were noted. Read More

    Proliferating tricholemmal tumour: clinicopathological aspects of a case.
    Singapore Med J 2011 Dec;52(12):e255-7
    Sindh Medical College, Dow University of Health Sciences, Baba-E-Urdu Road, Karachi 74200, Pakistan.
    We report the case of a 49-year-old man who presented with an enlarging mass over his occipital scalp. The clinical impression was either a squamous cell carcinoma or an unusual adnexal tumour. A wide excision was performed with skin grafting. Read More

    Posttraumatic giant proliferating trichilemmal cysts on the parietal region of the scalp.
    Indian J Dermatol Venereol Leprol 2011 Nov-Dec;77(6):707-9
    Department of Pathology, Reconstructive and Esthetic Surgery, Duzce University of Medical Faculty, Duzce, 81000, Turkey.
    Proliferating trichilemmal (pilar) cysts, also known as pilar tumors, are most commonly found on the scalp of elderly women. Proliferating trichilemmal cysts are rare, slowly growing, lobular masses inherited autosomal dominantly and localized on scalps, and believed to arise due to a complication of a trauma and inflammation, and 5-10% of people are reported to be effected. Herein, we present the case of a 70-year-old woman with a 23-year history of multiple enlarging scalp masses. Read More

    Giant trichilemmal cyst at the neck region.
    J Craniofac Surg 2009 May;20(3):961-2
    Otorhinolaryngology Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Trichilemmal cyst (TC) is an adnexal skin tumor that usually occurs on the scalp. There is a female dominance in this tumor. Proliferating pilar tumors or cysts arise from this lesion, and the clinical differential diagnosis from TCs must be taken because of aggressive behavior of proliferating pilar tumor. Read More

    Malignant proliferating pilar tumors arising in KID syndrome: a report of two patients.
    Am J Med Genet A 2007 Apr;143A(7):734-41
    Department of Otolaryngology, Head and Neck Surgery, Kaiser Permanente, Oakland, CA, USA.
    We report on two young adults with KID syndrome and follicular hyperkeratosis, hidradenitis suppurativa of the groin, progressive development of proliferative pilar cysts and dissecting cellulitis of the scalp, who developed metastatic malignant pilar tumors. Based on our findings, we believe that cancer surveillance in patients with KID syndrome should include screening for pilar tumors and their early removal to avoid development of malignant proliferating pilar tumors with poor prognosis. Read More

    Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two.
    J Cutan Pathol 2006 Apr;33(4):261-79
    Department of Pathology, Stanford University, Palo Alto, CA 94305, USA.
    Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential. However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC. No definitive, comprehensive clinicopathological system dividing cutaneous SCCs into categories based upon their aggressiveness has yet been promulgated. Read More

    Proliferating trichilemmal cysts of the scalp on CT.
    AJNR Am J Neuroradiol 2006 Mar;27(3):712-4
    Department of Radiology, University of South Florida College of Medicine, Tampa, Fla, USA.
    Proliferating trichilemmal cysts, also known as pilar tumors, are slow-growing lobulated masses most commonly found on the scalp of elderly women. We present the case of a 69-year-old woman with a 25-year history of multiple enlarging scalp masses. The patient was evaluated for surgical consultation after the dominant mass presented with malignant degeneration. Read More

    Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.
    J Cutan Pathol 2006 Mar;33(3):191-206
    Department of Pathology, Stanford University, Palo Alto, CA 94305, USA.
    Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential. However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC. No definitive, comprehensive clinicopathological system dividing cutaneous SCCs into categories based upon their aggressiveness has yet been promulgated. Read More

    Giant proliferating trichilemmal tumor of the gluteal region.
    Dermatol Surg 2005 Dec;31(12):1734-6
    Department of Dermatology, Afyon Kocatepe University, Turkey.
    Background: Proliferating trichilemmal tumors are rare cutaneous neoplasms that show features of typical pilar cysts but also show extensive epithelial proliferation, variable cytologic atypia, and mitotic activity. Proliferating trichilemmal tumors are benign lesions; however, there are numerous reports of malignant proliferating trichilemmal tumors.

    Objective: We present a case of benign proliferating trichilemmal tumor of an 81-year-old woman that was located on the left superior gluteal region for 30 years. Read More

    Nucleolar organizer regions (NORs) in simple and proliferating trichilemmal cysts (pilar cysts and pilar tumors).
    Indian J Pathol Microbiol 2004 Oct;47(4):469-73
    Department of Pathology, TN Medical College & BYL Nair Charitable Hospital, Mumbai-Central, Mumbai.
    Simple trichilemmal cysts or pilar cysts and pilar tumors are relatively rare entities often under-reported by pathologists. The pilar cysts are thought to proliferate and progress to pilar tumors. These pilar tumors can further undergo malignant change. Read More

    Cytokeratin 5/6 immunostaining in cutaneous adnexal neoplasms and metastatic adenocarcinoma.
    Am J Dermatopathol 2004 Dec;26(6):447-51
    Departments of Pathology and Dermatology, University of Washington, Seattle, Washington, USA.
    The differentiation of primary cutaneous adnexal neoplasms (CANs) from dermal-based metastatic lesions can be difficult. Cytokeratin 5/6 (CK 5/6) has a relatively limited expression profile, being relatively specific for mesothelium and other "pavement" type epithelium such as squamous epithelium. To date, the degree and distribution of CK 5/6 expression in cutaneous neoplasms has not been extensively studied. Read More

    Expression of the peripheral benzodiazepine receptor is decreased in skin cancers in comparison with normal skin.
    Br J Dermatol 2004 Oct;151(4):846-56
    Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
    Background: The peripheral benzodiazepine receptor (PBR) is an 18-kDa protein receptor mainly found on the outer mitochondrial membrane of cells. The PBR plays a role in several cellular functions including haem synthesis, steroidogenesis, DNA synthesis, cell growth and differentiation, and apoptosis. PBR expression in normal skin correlates with proliferating, secretory and differentiated cellular structures. Read More

    Proliferating pilar tumors: a clinicopathologic study of 76 cases with a proposal for definition of benign and malignant variants.
    Am J Clin Pathol 2004 Oct;122(4):566-74
    Dahl-Chase Pathology Associates, Bangor, ME, USA.
    We studied proliferating pilar tumors (PPTs) to establish histologic criteria that could predict behavior. We reviewed all cases in our consultation files (1989-2000) and evaluated 76 cases with meaningful follow-up information. Histologic examination involved attention to tumor silhouette, degree of nuclear atypia, mitotic activity, necrosis, and perineurial or angiolymphatic invasion. Read More

    Proliferating trichilemmal tumors: clinicopathologic evaluation is a guide to biologic behavior.
    J Cutan Pathol 2003 Sep;30(8):492-8
    Emory University, Atlanta, GA, USA.
    Background: Trichilemmal (pilar) cysts are common skin lesions that usually occur on the scalp of elderly women. They differentiate towards the follicular outer root sheath epithelium and show trichilemmal keratinization. Proliferating trichilemmal tumor (PTT) shows features of typical pilar cyst, but additionally shows extensive epithelial proliferation, variable cytologic atypia and mitotic activity. Read More

    Differentiation between malignant and benign follicular adnexal tumours of the skin by DNA image cytometry.
    Br J Dermatol 2002 Feb;146(2):238-43
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str. 5, D-30449 Hannover, Germany.
    Background: We have demonstrated in previous studies that DNA image cytometry (DNA ICM) can be helpful in detecting malignancy in sebaceous tumours of the Muir-Torre syndrome and sweat gland tumours. However, little is known about DNA ICM in cutaneous adnexal tumours with follicular differentiation.

    Objectives: To study a larger series of benign and malignant follicular adnexal tumours with DNA ICM. Read More

    Cytodiagnosis of simple and proliferating trichilemmal cysts.
    Acta Cytol 2001 Jul-Aug;45(4):582-8
    Department of Pathology, Bai Yamunabai Laxman Nair Ch. Hospital and Topiwala National Medical College, Mumbai, India.
    Objective: To elucidate the cytologic findings in simple trichilemmal (pilar) cysts and proliferating trichilemmal cysts (pilar tumors) and the clinical importance of these lesions.

    Study Design: Aspirates from 12 simple pilar cysts and three pilar tumors, all histologically confirmed, were analyzed with a view to elaborating on specific cytologic features enabling a distinction from epidermal cysts and other adnexal tumors.

    Results: Aspirates from pilar cysts showed two different pictures, depending on the age of the cyst. Read More

    Malignant proliferating trichilemmal tumor.
    Am J Clin Oncol 2001 Aug;24(4):351-3
    Department of Surgery, Catholic Health Partners, Chicago, Illinois, USA.
    Proliferating trichilemmal tumors are uncommon neoplasms that are usually benign, but characterized by frequent local recurrence. In this report, we describe a patient who sought treatment at our clinic for a right occiput scalp nodule measuring 1 cm in diameter. The subcutaneous lesion was mobile and without overlying skin ulceration. Read More

    Malignant proliferating trichilemmal tumour: a case report.
    Malays J Pathol 1999 Dec;21(2):117-21
    Department of Pathology, Hospital Sultanah Aminah Johor Baru.
    An 86-year-old man presented with a painless, pea-sized growth over the left angle of his jaw, which had been gradually enlarging over two years. A clinical diagnosis of pilar cyst was made. Histopathological examination of the mass revealed a malignant proliferating trichilemmal tumour. Read More

    Microcystic adnexal carcinoma of the skin. A reappraisal of the differentiation and differential diagnosis of an underrecognized neoplasm.
    J Am Acad Dermatol 1993 Oct;29(4):609-18
    Department of Pathology, University of California at San Francisco, School of Medicine 94143-0506.
    Background: Microcystic adnexal carcinoma (MAC) is a locally aggressive adnexal neoplasm whose histogenesis is disputed. Many cases referred to us had been misdiagnosed.

    Objective: Our purpose was to clarify the differential diagnosis and differentiation of MAC. Read More

    Malignant change in trichilemmal cysts: a study of cell proliferation and DNA content.
    Histopathology 1992 Nov;21(5):465-8
    Department of Histopathology, Mount Vernon Hospital, Northwood, Middlesex, UK.
    We have examined proliferative activity in a series of pilar and trichilemmal cysts using an antibody to proliferating cell nuclear antigen. In benign lesions proliferative activity was confined to the basal layers of the squamous epithelium. Lesions showing malignant change showed increased proliferative activity and were not confined to the basal layer. Read More

    A case of multiple pilar tumors and pilar cysts involving the scalp and back.
    Plast Reconstr Surg 1991 Apr;87(4):763-7
    Division of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pa.
    The case of a patient with multiple proliferating trichilemmal tumors and trichilemmal cysts of the scalp and back is discussed. The multicentric presentation of this tumor is unusual and, to our knowledge, has not been described previously. The appearance of trichilemmal cysts in association with multiple proliferating trichilemmal tumors suggests a common histogenesis of these two neoplasms. Read More

    Proliferating trichilemmal tumor of the vulva. Case report and review of the literature.
    Int J Gynecol Pathol 1989 ;8(2):163-8
    Institute of Pathology, Soroka Medical Center, Negev, Beer-Sheva, Israel.
    A case of proliferating trichilemmal tumor, otherwise known as pilar tumor, occurring in the dermis of the left labium majus of a 65-year-old woman, is presented. To our knowledge, this is the second reported case of such a tumor occurring in this location. The origin of this neoplasm, the reasons for its rarity at this site, and the range of its biological behavior are discussed in relation to the clinical manifestations of this case. Read More

    Malignant proliferating trichilemmal tumors--report of three cases.
    J Dermatol Surg Oncol 1987 Dec;13(12):1339-42
    Pinkus Dermatopathology Laboratory, Monroe, MI 48161-0360.
    We are reporting three patients with recent history of rapid enlargement of long standing nodular scalp lesions. Histologic sections revealed areas of relatively benign proliferation of pilar sheath epithelium and foci of trichilemmal keratinization characteristic of a proliferating trichilemmal cyst. There were also extensive areas of severe cellular dysplasia and surrounding dermal invasion indicating malignant transformation. Read More

    Malignant change in cysts of the skin.
    Ann Plast Surg 1986 Mar;16(3):253-6
    Division of Plastic Surgery, University of Vermont College of Medicine, Burlington.
    The concept that squamous carcinoma arises with any frequency from common skin cysts is examined. We believe this to be extremely rare and suggest that many of the previously reported cases are pilar tumors or proliferating trichilemmal cysts, a benign but clinically impressive lesion occurring most commonly in the scalps of older women. An illustrative case is presented. Read More

    Infundibular and trichilemmal keratinization of a pilar tumor.
    Cutis 1985 Oct;36(4):330-2
    Microscopic examination of a cystic epithelial tumor removed from the elbow of a 52-year-old man showed islands of epithelium undergoing keratinization without formation of a visible granular cell layer, as occurs within the follicular isthmus, in trichilemmal cysts, and in pilar tumors (proliferating trichilemmal cysts). Other areas showed keratinization with the formation of a distinct, even prominent, granular cell layer, as seen within the follicular infundibulum and in epidermal cysts. Possible modes of origin and relationships among these tumors and epidermal cysts are presented. Read More

    Proliferating pilar (trichilemmal) cyst. Report of two cases, one with carcinomatous transformation and one with distant metastases.
    Arch Pathol Lab Med 1984 Oct;108(10):808-10
    We examined two cases of proliferating pilar cysts of the inguinal region. One of the cases showed a transformation to epidermoid carcinoma and, despite surgical resection, the patient died by means of distant generalized metastases. The diagnosis of proliferating pilar cyst should be made in pilar cysts with epithelial proliferation that shows well-defined borders and abundant keratinization despite cytologic atypia and mitotic activity. Read More

    [The infundibular adenoma: a follicular poroma with sebaceous and apocrine differentiation (author's transl)].
    Ann Dermatol Venereol 1981 ;108(1):59-66
    Tricholemmal adnexal pilar tumors may be classified according to the tricholemmal zone whose structure they reproduce and according to their degree of maturation or dedifferentiation. The pilar sheath acanthoma (dilated pore of Winer), the tumor of follicular infundibulum and the follicular poroma (inverted follicular keratosis) are related to the infundibulum and keratinize according to the epidermal pattern. The tricholemmal cysts (of simple or proliferating type) and the keratinizing tricholemmoma are related to the upper part of the isthmus of the anagen hair and keratinize according to the specific pattern of the outer root sheath at this isthmic level. Read More

    Proliferating pilar cyst with spindle cell component.
    J Cutan Pathol 1979 Aug;6(4):310-6
    Proliferating pilar cysts are rare tumors which occur most commonly on the scalp of elderly women. The infiltrative areas of these tumors should be differentiated from epidermoid carcinoma because they are usually benign. The intimate association of this entity with a spindle cell component is described here, to our knowledge for the first time. Read More

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