48,935 results match your criteria Proliferating Pilar Tumor


Recruitment of macrophages and bone marrow stem cells to regenerating liver promoted by sodium phthalhydrazide in mice.

Biomed Pharmacother 2018 Dec 8;110:594-601. Epub 2018 Dec 8.

Institute of Immunopathology and Preventive Medicine, Povsetova ulica 29, 1000 Lublana, Slovenia. Electronic address:

Pharmacological interventions which could be hepatoprotective, depending on bioavailability, anti-inflammatory and macrophage-targeting potential of drugs, are still at early preclinical stages. Existing evidence from many animal models of liver injury, as well as from human data, indicate that pharmacological and/or phytochemical interventions have limited impact on liver recovery. Recent studies on stem cell therapies focused on different cell subsets involved in tissue repair, including monocytes/macrophages and bone marrow cells migrating to the injured liver. Read More

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December 2018
1 Read

Quantifying Proliferative and Surface Marker Heterogeneity in Colony Founding Connective Tissue Progenitors and Their Progeny Using Time-Lapse Microscopy.

J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.

Dept. of Biomedical Engineering, Cleveland Clinic, Cleveland, OH.

Connective tissue progenitors (CTPs) are defined as the heterogeneous population of tissue-resident stem and progenitor cells that are capable of proliferating and differentiating into connective tissue phenotypes. The prevalence and variation in clonal progeny of CTPs can be characterized using a colony formation assay. However, colony assays do not directly assess the characteristics of the colony founding CTP. Read More

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December 2018

50-Hz MF does not affect global DNA methylation of SH-SY5Y cells treated with the neurotoxin MPP.

Bioelectromagnetics 2018 Dec 7. Epub 2018 Dec 7.

Division of Health Protection Technologies, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rome, Italy.

Exposure to extremely low frequency magnetic fields (ELF-MFs) has been associated with an increased risk of neurodegenerative disorders. The underlying mechanisms, however, are still debated. Since epigenetics play a key role in the neurodegenerative process, we investigated whether exposure to ELF-MF (50 Hz, 1 mT) might affect global DNA methylation of SH-SY5Y dopaminergic-like neuroblastoma cells. Read More

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December 2018

Persistence of fluorescent nanoparticle-labeled bone marrow mesenchymal stem cells in vitro and after intra-articular injection.

J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.

Mesenchymal stem cells (MSCs) improve the osteoarthritis condition, but the fate of MSCs after intra-articular injection is unclear. We used fluorescent nanoparticles (quantum dots; QDs) to track equine MSCs (QD-MSCs) in vivo after intra-articular injection to normal and osteoarthritic joints. One week after injection of QD-MSCs, unlabeled MSCs, or vehicle we determined the presence of QD-MSCs in synovium and articular cartilage histologically. Read More

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December 2018

Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy.

Cytometry A 2018 Dec 11. Epub 2018 Dec 11.

Biomedical Engineering Department, University of California, Irvine, California.

Characterization of single cell metabolism is imperative for understanding subcellular functional and biochemical changes associated with healthy tissue development and the progression of numerous diseases. However, single-cell analysis often requires the use of fluorescent tags and cell lysis followed by genomic profiling to identify the cellular heterogeneity. Identifying individual cells in a noninvasive and label-free manner is crucial for the detection of energy metabolism which will discriminate cell types and most importantly critical for maintaining cell viability for further analysis. Read More

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December 2018

Identification and Isolation of Clonogenic Cholangiocyte in Mouse.

Methods Mol Biol 2019 ;1905:19-27

Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA.

Cholangiocytes are proliferative and are one of the sources for liver progenitor cells. Clonogenic cholangiocytes are defined as cells capable of clonally proliferating and differentiating cholangiocytes both in vitro and in vivo. In this protocol, we describe the method for isolation of primary cholangiocytes from mouse. Read More

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January 2019

Cuticular drusen associated with aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy).

Int J Retina Vitreous 2018 5;4:44. Epub 2018 Dec 5.

1Vitreous Retina Macula Consultants of New York, 460 Park Ave., New York, NY 10022 USA.

Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes.

Case Presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination. Read More

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December 2018

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways.

Sci Rep 2018 Dec 7;8(1):17702. Epub 2018 Dec 7.

Laboratory for Biomedical Neurosciences, Neurocenter of Southern Switzerland, Ente Cantonale Ospedaliero, Torricella-Taverne, Switzerland.

Post-translational protein modification controls the function of Tau as a scaffold protein linking a variety of molecular partners. This is most studied in the context of microtubules, where Tau regulates their stability as well as the distribution of cellular components to defined compartments. However, Tau is also located in the cell nucleus; and is found to protect DNA. Read More

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December 2018

The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma.

Clin Cancer Res 2018 Dec 7. Epub 2018 Dec 7.

Clinical Cooperation Unit Pediatric Oncology (G340), Hopp Children's Cancer Center Heidelberg (KiTZ)

Purpose: Pilocytic astrocytoma (PA) is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced senescence (OIS), which may cause unpredictable growth behavior of PAs. The senescence-associated secretory phenotype (SASP) has been shown to regulate OIS, but its role in PA remains unknown. Read More

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December 2018

PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication.

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801

RING finger and WD repeat domain-containing protein 3 (RFWD3) is an E3 ligase known to facilitate homologous recombination by removing replication protein A (RPA) and RAD51 from DNA damage sites. Further, RPA-mediated recruitment of RFWD3 to stalled replication forks is essential for interstrand cross-link repair. Here, we report that in unperturbed human cells, RFWD3 localizes at replication forks and associates with proliferating cell nuclear antigen (PCNA) via its PCNA-interacting protein (PIP) motif. Read More

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December 2018

Profiling proliferative cells and their progeny in damaged murine hearts.

Proc Natl Acad Sci U S A 2018 Dec 7. Epub 2018 Dec 7.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, 3584 CT Utrecht, The Netherlands;

The significance of cardiac stem cell (CSC) populations for cardiac regeneration remains disputed. Here, we apply the most direct definition of stem cell function (the ability to replace lost tissue through cell division) to interrogate the existence of CSCs. By single-cell mRNA sequencing and genetic lineage tracing using two Ki67 knockin mouse models, we map all proliferating cells and their progeny in homoeostatic and regenerating murine hearts. Read More

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December 2018

Hypoxia: A breath of fresh air for the meibomian gland.

Ocul Surf 2018 Dec 4. Epub 2018 Dec 4.

Schepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA.

Purpose: Optimal meibomian gland (MG) function is critically important for the health and wellbeing of the ocular surface. We hypothesize that low oxygen (O) conditions promote the function of human MG epithelial cells (HMGECs) and that human MGs exist in a relatively hypoxic environment. The purpose of this study was to test our hypotheses. Read More

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December 2018

Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review.

Stem Cell Res Ther 2018 Dec 7;9(1):336. Epub 2018 Dec 7.

Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece.

Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly proliferating cells that can be isolated from adult (e.g., bone marrow, adipose tissue) as well as fetal (e. Read More

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December 2018

Study protocol of a 4- parallel arm, superiority, community based cluster randomized controlled trial comparing paper and e-platform based interventions to improve accuracy of recall of last menstrual period (LMP) dates in rural Bangladesh.

BMC Public Health 2018 Dec 10;18(1):1359. Epub 2018 Dec 10.

Maternal and Child Health Division, icddr,b, Dhaka, 1212, Bangladesh.

Background: Gestational age (GA) is a key determinant of newborn survival and long-term impairment. Accurate estimation of GA facilitates timely provision of essential interventions to improve maternal and newborn outcomes. Menstrual based dating, ultrasound based dating, and neonatal estimates are the primarily used methods for assessing GA; all of which have some strength and weaknesses that require critical consideration. Read More

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December 2018

RNA regulons are essential in intestinal homeostasis.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

Pediatrics, GI Division, Children's Hospital of Philadelphia, United States.

Intestinal epithelial cells are among the most rapidly proliferating cell types in the human body. There are several different sub-types of epithelial cells, each with unique functional roles in responding to the ever-changing environment. The epithelium's ability for rapid and customized responses to environmental changes requires multi-tiered levels of gene regulation. Read More

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December 2018

Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis.

J Ethnopharmacol 2018 Nov 30. Epub 2018 Nov 30.

Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon. Electronic address:

Ethnopharmacological Relevance: Ulmus macrocarpa Hance (UMH), of the family Ulmaceae, is a deciduous tree, widely distributed throughout Korea. UMH has been used as a traditional oriental medicine in Korea for the treatment of urological disorders, including bladder outlet obstrulmition (BOO), lower urinary tract syndrome (LUTS), diuresis, and hematuria. To date, its possible protective effects against benign prostatic hyperplasia (BPH) have not been analyzed. Read More

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November 2018

Vasculature reconstruction of decellularized liver scaffolds via gelatin-based re-endothelialization.

J Biomed Mater Res A 2018 Dec 3. Epub 2018 Dec 3.

Organ Transplantation Center, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia.

Decellularized liver scaffolds based liver engineering is a promising approach toward developing functional liver surrogates. However, a major obstacle to long-term transplantation is the hemocompatibility of the bioengineered liver surrogates. One approach to improve the hemocompatibility of engineered liver surrogates is re-endothelialization. Read More

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December 2018
2 Reads

Raman and infrared spectroscopy reveal that proliferating and quiescent human fibroblast cells age by biochemically similar but not identical processes.

PLoS One 2018 3;13(12):e0207380. Epub 2018 Dec 3.

Spectroscopy and Imaging, Leibniz Institute of Photonic Technology, Jena, Germany.

Dermal fibroblast cells can adopt different cell states such as proliferation, quiescence, apoptosis or senescence, in order to ensure tissue homeostasis. Proliferating (dividing) cells pass through the phases of the cell cycle, while quiescent and senescent cells exist in a non-proliferating cell cycle-arrested state. However, the reversible quiescence state is in contrast to the irreversible senescence state. Read More

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December 2018

Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury.

Hepatology 2018 Dec 2. Epub 2018 Dec 2.

Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation and differentiation to restore biliary epithelial integrity. However, formal evidence for this concept in human livers is lacking. Read More

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December 2018

Overexpression of microRNA-98 inhibits cell proliferation and promotes cell apoptosis via claudin-1 in human colorectal carcinoma.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Colorectal carcinoma (CRC) is a major cause of cancer-related deaths worldwide, and investigations on novel targets are imperative. MiR-98 has been reported to act as a tumor suppressor in several cancers. To evaluate miR-98 as a novel anticancer molecule for CRC, examinations to validate whether miR-98 conferred an inhibiting effect on proliferation, migration, and invasion were performed. Read More

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December 2018

Endocytosis in proliferating, quiescent and terminally differentiated cells.

J Cell Sci 2018 Nov 30;131(23). Epub 2018 Nov 30.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK

Endocytosis mediates nutrient uptake, receptor internalization and the regulation of cell signaling. It is also hijacked by many bacteria, viruses and toxins to mediate their cellular entry. Several endocytic routes exist in parallel, fulfilling different functions. Read More

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November 2018

Uterine histopathological changes induced by acute administration of tamoxifen and its modulation by sex steroid hormones.

Toxicol Appl Pharmacol 2018 Nov 29;363:88-97. Epub 2018 Nov 29.

UCIBIO, REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, University of Porto, Porto, Portugal.

The endometrium is a particular sensitive target tissue for estradiol that is able to promptly modify its structure. Tamoxifen (TAM), a selective estrogen receptor modulator, was shown to promote a spectrum of uterine abnormalities, though the morphological and stereological effects of this drug in uterus is not clear. In this way, we have used an established model of ovariectomy followed by estradiol benzoate (EB) or TAM treatment and analyzed their effects in uterine histopathology and proliferation. Read More

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November 2018

Proteasome inhibition prevents cell death induced by the chemotherapeutic agent cisplatin downstream of DNA damage.

DNA Repair (Amst) 2018 Oct 25. Epub 2018 Oct 25.

Centro de Biologia Molecular e Ambiental, Departamento de Biologia, Universidade do Minho, Braga, Portugal. Electronic address:

Cisplatin is a highly effective chemotherapeutic drug acting as a DNA-damaging agent that induces apoptosis of rapidly proliferating cells. Unfortunately, cellular resistance still occurs. Mutations in p53 in a large fraction of tumor cells contribute to defects in apoptotic pathways and drug resistance. Read More

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October 2018

Morphometric and gene expression analyses of stromal expansion during development of the bovine fetal ovary.

Reprod Fertil Dev 2018 Dec 3. Epub 2018 Dec 3.

During ovarian development stroma from the mesonephros penetrates and expands into the ovarian primordium and thus appears to be involved, at least physically, in the formation of ovigerous cords, follicles and surface epithelium. Cortical stromal development during gestation in bovine fetal ovaries (n = 27) was characterised by immunohistochemistry and by mRNA analyses. Stroma was identified by immunostaining of stromal matrix collagen type I and proliferating cells were identified by Ki67 expression. Read More

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December 2018

Protective effects of either C-peptide or l-arginine on pancreatic β-cell function, proliferation, and oxidative stress in streptozotocin-induced diabetic rats.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Anatomy, Faculty of Medicine, Minia University, Minia, Egypt.

Diabetes and cardiometabolic risk factors including hypertension and dyslipidemia are the major threats to human health in the 21st century. Apoptosis in pancreatic tissue is one of the major causes of diabetes type 1 progression. The aim of this study was to investigate the effects of C-peptide or l-arginine on some cardiometabolic risk factors, pancreatic morphology, function and apoptosis, and the mechanisms of their actions. Read More

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December 2018

Interactome determination of a Long Noncoding RNA implicated in Embryonic Stem Cell Self-Renewal.

Sci Rep 2018 Dec 4;8(1):17568. Epub 2018 Dec 4.

Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.

Long noncoding RNAs (lncRNAs) constitute a significant fraction of mammalian transcriptomes and they have emerged as intricate regulators of many biological processes. Their broad capacity to adopt diverse structures facilitates their involvement in the transcriptional, translational and signaling processes that are central to embryonic stem (ES) cell self-renewal and pluripotency. While lncRNAs have been implicated in ES cell maintenance, detailed analyses of those that show significant expression in ES cells is largely absent. Read More

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December 2018

Diabetes-induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: the protective role of metformin.

Arch Physiol Biochem 2018 Dec 4:1-12. Epub 2018 Dec 4.

a Department of Physiology, School of Medical Sciences , Universiti Sains Malaysia , Kubang Kerian , Kelantan , Malaysia.

Context: Metformin's effect on glycaemic control is well documented, but its effect on diabetes-induced testicular impairment has been scarcely reported.

Objective: To investigate the effects of metformin on testicular oxidative stress, inflammation, and apoptosis, which largely contribute to fertility decline in diabetic state.

Methods: Male Sprague-Dawley rats were divided into 3 groups (n = 6/group) namely: normal control (NC), diabetic control (DC), and metformin (300 mg/kg b. Read More

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December 2018
4 Reads

Assisting Rapid Soft-Tissue Expansion with Adipose-Derived Stem Cells: An Experimental Study in a Pig Model.

Plast Reconstr Surg 2018 Nov;142(5):674e-684e

Beijing, People's Republic of China From the Head & Neck Aesthetic and Plastic Surgery Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Background: Rapid tissue expansion has been attempted, aiming at shortening the period of conventional expansion. However, it has scarcely been clinically applied because of its drawbacks such as low expansion efficiency and tissue destruction. Adipose-derived stem cell transplantation is a promising therapeutic method in regenerative medicine. Read More

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November 2018
3 Reads

Effect of Upregulated DNA Replication and Sister Chromatid Cohesion 1 Expression on Proliferation and Prognosis in Hepatocellular Carcinoma.

Chin Med J (Engl) 2018 Dec;131(23):2827-2835

Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Background: DNA replication and sister chromatid cohesion 1 (DSCC1) (also called DCC1) is a component of an alternative replication factor C complex that loads proliferating cell nuclear antigen onto DNA during S phase of the cell cycle. It is located at 8q24 and frequently amplified in hepatocellular carcinoma (HCC). However, the role of DSCC1 in the carcinogenesis and progress of HCC has not been fully investigated. Read More

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December 2018

Histone deacetylase inhibitors suppress transdifferentiation of gonadotrophs to prolactin cells and proliferation of prolactin cells induced by diethylstilbestrol in male mouse pituitary.

Histochem Cell Biol 2018 Dec 3. Epub 2018 Dec 3.

Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Diethylstilbestrol (DES), an estrogen agonist, increases prolactin (PRL) cells through transdifferentiation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) cells to PRL cells as well as proliferation of PRL cells in adult male mouse pituitary. Since hyperacetylation of histone H3 is implicated in the regulation of activation of various genes, we examined the effect of DES on the state of histone H3 acetylation. DES significantly reduced the immunohistochemical signal for acetylated histone H3 at lysine 9 (H3K9ac) in PRL, LH and FSH cells, but not for H3K18ac or H3K23ac. Read More

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December 2018
1 Read

Troxerutin down-regulates KIM-1, modulates p38 MAPK signaling, and enhances renal regenerative capacity in a rat model of gentamycin-induced acute kidney injury.

Food Funct 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Pharmacy, College of Clinical Pharmacy, Taif University, Taif 21974, Saudi Arabia.

Gentamycin is an aminoglycoside antibiotic that is widely employed for controlling Gram negative bacterial infections including that caused by the antibiotic-resistant Pseudomonas species. The clinical use of gentamycin is substantially limited by its side effects particularly acute kidney injury (AKI). The aim of the current study was to investigate the protective effect of the plant flavonoid troxerutin (150 mg kg-1 day-1 for 15 days) against gentamycin-induced AKI using Wistar rats as an experimental mammalian model. Read More

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December 2018
1 Read

The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway.

BMC Cancer 2018 Dec 3;18(1):1201. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Peritoneal dissemination is a critical prognostic factor in ovarian cancer. Although stabilized spheroid formation promotes cancer cell peritoneal dissemination in ovarian cancer, the associated oncogenes are unknown. In this study, we assessed the role of the KRAS oncogene in ovarian cancer cell dissemination, focusing on the stability of cells in spheroid condition, as well as the modulation of intracellular signaling following spheroid transformation. Read More

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December 2018
3 Reads

High level EGFR amplification in a newly established glioblastoma cell line 170-MG-BA.

Neoplasma 2018 Aug 9. Epub 2018 Aug 9.

Department of Anatomy, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

Glioblastoma multiforme is a highly invasive and incurable primary brain tumor. The most frequent genetic alteration therein is amplification of the epidermal growth factor receptor (EGFR) gene, the target of current clinical trials. However, EGFR amplification is poorly adapted to glioblastoma cell lines. Read More

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Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Cell 2018 Nov;175(6):1591-1606.e19

Oncode Institute, Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands; University Medical Center Utrecht, Cancer Genomics Netherlands, 3584CX Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

The mammalian liver possesses a remarkable regenerative ability. Two modes of damage response have been described: (1) The "oval cell" response emanates from the biliary tree when all hepatocytes are affected by chronic liver disease. (2) A massive, proliferative response of mature hepatocytes occurs upon acute liver damage such as partial hepatectomy (PHx). Read More

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November 2018
2 Reads

Subnutrition Effects During Pregnancy and Lactation on Mitosis, Apoptosis, and Androgen Receptor Expression in the Rat Testis.

Reprod Domest Anim 2018 Nov 30. Epub 2018 Nov 30.

Area of Histology and Embryology, Department of Morphology and Development, Veterinary Faculty, University of Uruguay.

In order to study the effect of undernutrition during gestation on the testicular development in rats and its impact on mitosis, apoptosis and the relative abundance of androgen receptor expression, twenty primiparous 3 months old Sprague-Dawley (Rattus norvegicus) rats, weighing 246 ± 4,0 grams when the experiment began, were mated by the same male. Control group (CG), n=10, fed ad libitum with water and rat chow and restricted group (RG, n=10), fed throughout pregnancy and until birth with 40% of the ad libitum maternal daily feed intake. Litters from both groups suckled for 25 days, RG with 14 pups/litter and CG with 8 pups/litter. Read More

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November 2018
1 Read

Molecular Ultrasound Assessment of Glioblastoma Neovasculature with Endoglin-Targeted Microbubbles.

Contrast Media Mol Imaging 2018 18;2018:8425495. Epub 2018 Oct 18.

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China.

Objectives: Glioblastoma, as one of the most malignant cancer in the world, usually shows substantially increased angiogenesis. Endoglin (CD105), which is an alternative proangiogenic growth factor, has been remarkably upregulated on the proliferating glioblastoma neovasculature. However, little is known on the noninvasive assessment of the expression levels of CD105 during glioblastoma progression. Read More

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October 2018

Tetrabromobisphenol-A Promotes Early Adipogenesis and Lipogenesis in 3T3-L1 Cells.

Toxicol Sci 2018 Dec;166(2):332-344

National Toxicology Program Laboratory (NTPL), Division of the National Toxicology Program, National Institutes of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.

Tetrabromobisphenol A (TBBPA) is the most common flame retardant used in electrical housings, circuit boards, and automobiles. High-throughput screening and binding assays have identified TBBPA as an agonist for human peroxisome proliferator-activated receptor gamma (PPARγ), the master regulator of adipogenesis. TBBPA has been suggested to be an obesogen based on in vitro cellular assays and zebrafish data. Read More

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December 2018

Novel sub-cellular localizations and intra-molecular interactions may define new functions of Mixed Lineage Leukemia protein.

Cell Cycle 2018 Nov 29. Epub 2018 Nov 29.

a Laboratory of Cell Cycle Regulation , Centre for DNA Fingerprinting and Diagnostics (CDFD) , Uppal , Hyderabad , India.

Mixed-lineage leukemia (MLL) protein is one the best-characterized member of SET family of histone 3 lysine 4 methyltransferase, known for its transcriptional-activation role during development. mll gene rearrangements cause multiple kinds of aggressive leukemia in both children and adults. An important 'first' step in understanding the role of MLL in leukemogenesis would be to identify its localization throughout the cell cycle. Read More

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November 2018

Antigen-specific CD8 T cells in cell cycle circulate in the blood after vaccination.

Scand J Immunol 2018 Nov 29:e12735. Epub 2018 Nov 29.

Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.

Although clonal expansion is a hallmark of adaptive immunity, the location(s) where antigen-responding T cells enter cell cycle and complete it have been poorly explored. This lack of knowledge stems partially from the limited experimental approaches available. By using Ki67 plus DNA staining and a novel strategy for flow cytometry analysis, we distinguished antigen-specific CD8 T cells in G , in G , and in S-G /M phases of cell cycle after intramuscular vaccination of BALB/c mice with antigen-expressing viral vectors. Read More

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November 2018
4 Reads

HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of Vaccinia-related kinase 2.

J Neurochem 2018 Nov 29. Epub 2018 Nov 29.

Department of Life Sciences, Pohang University of Science and Technology (POSTECH).

Misfolded proteins with abnormal polyglutamine (polyQ) expansion cause neurodegenerative disorders, including Huntington's disease (HD). Recently, it was found that polyQ aggregates accumulate due to vaccinia-related kinase 2 (VRK2)-mediated degradation of TCP-1 ring complex (TRiC)/Chaperonin-containing TCP-1 (CCT), which has an essential role in the prevention of polyQ protein aggregation and cytotoxicity. The levels of VRK2 are known to be much higher in actively proliferating cells but are maintained at a low level in the brain via an unknown mechanism. Read More

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November 2018

Increased Mucin Expression in Oral Mucosal Epithelial Cells in vitro: A Potential New Role of Mycophenolate Mofetil.

Tokai J Exp Clin Med 2018 Dec 20;43(4):132-138. Epub 2018 Dec 20.

Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi-110029, India:

Objective: Autologous cultured explants of human oral mucosal epithelial cells (OMEC) are a potential therapeutic modality in patients of bilateral ocular surface disease (OSD) with incapacitating dry eye. Mycophenolate mofetil (MMF) has been found to upregulate the mucin production in conjunctival goblet cells in vitro. The aim of this study was to evaluate the effects of MMF on mucin expression in primary cultures of OMEC. Read More

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December 2018

Ectopic Organogenesis after Allotransplantation of Freshly Removed or Cryopreserved Neonatal Testicle under the Renal Capsule in Rats.

Bull Exp Biol Med 2018 Dec 28;166(2):268-273. Epub 2018 Nov 28.

All-Russian Institute of Scientific and Technical Information, Russian Academy of Sciences, Moscow, Russia.

In experiments on white outbred male rats, a freshly removed (20 experiments) or cryopreserved (10 experiments) testicle from newborn rats (1-2 days after birth) was transplanted under the renal capsule after bilateral orchiectomy. In all experiments with transplantation of freshly removed testicle, it was engrafted. In 3 months, histological examination revealed the formation of mature seminiferous tubules, but spermatogenesis was blocked at the stage of spermatogonia; groups of proliferating Leydig cells in the loose connective tissue between the tubules were also seen. Read More

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December 2018
1 Read

SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines.

Proc Natl Acad Sci U S A 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan

DNA damage tolerance (DDT) releases replication blockage caused by damaged nucleotides on template strands employing two alternative pathways, error-prone translesion DNA synthesis (TLS) and error-free template switch (TS). Lys164 of proliferating cell nuclear antigen (PCNA) is SUMOylated during the physiological cell cycle. To explore the role for SUMOylation of PCNA in DDT, we characterized chicken DT40 and human TK6 B cells deficient in the PIAS1 and PIAS4 small ubiquitin-like modifier (SUMO) E3 ligases. Read More

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November 2018
9.809 Impact Factor

Smart Animal Agriculture: Application of Real-Time Sensors to Improve Animal Well-Being and Production.

Annu Rev Anim Biosci 2018 Nov 28. Epub 2018 Nov 28.

Natural Resources Institute Finland (Luke), Production Systems, FI-00790 Helsinki, Finland; email:

Consumption of animal products such as meat, milk, and eggs in first-world countries has leveled off, but it is rising precipitously in developing countries. Agriculture will have to increase its output to meet demand, opening the door to increased automation and technological innovation; intensified, sustainable farming; and precision livestock farming (PLF) applications. Early indicators of medical problems, which use sensors to alert cattle farmers early concerning individual animals that need special care, are proliferating. Read More

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November 2018

Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.

Stem Cells Transl Med 2018 Nov 28. Epub 2018 Nov 28.

Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

Tumorigenesis is an important problem that needs to be addressed in the field of human stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI). When certain "tumorigenic" cell lines are transplanted into the spinal cord of SCI mice model, there is initial improvement of motor function, followed by abrupt deterioration secondary to the effect of tumor growth. A significant proportion of the transplanted cells remains undifferentiated after transplantation and is thought to increase the risk of tumorigenesis. Read More

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November 2018
1 Read

Establishment of a novel testicular cell line from sterlet Acipenser ruthenus and evaluation of its applications.

J Fish Biol 2018 Nov 28. Epub 2018 Nov 28.

Beijing Fisheries Research Institute & National Freshwater Fisheries Engineering Technology Research Center, Ministry of Science and Technology of China, Beijing Key Laboratory of Fishery Biotechnology, Beijing, China.

In this study, a cell line, designated as ART, was successfully established from testis tissues of the sterlet Acipenser ruthenus and characterized by studying and comparing the expression of specific genes between the cell line and the parent gonad tissues. The results suggested that the developed ART cell line was composed of a mixture of germ cells and somatic cells. Ploidy analysis indicated that the cell line exhibited a high degree of genetic stability and that the cells remained in a good proliferating state after being subcultured to passage 80. Read More

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November 2018
1 Read

Expression of long non-coding RNA CCHE1 in colorectal carcinoma: correlations with clinicopathological features and ERK/COX-2 pathway.

Mol Biol Rep 2018 Nov 27. Epub 2018 Nov 27.

Clinical Pharmacy Department, Faculty of Pharmacy, AL-Delta University, Gamasa, Egypt.

Colorectal cancer (CRC) is among the leading causes of cancer-related mortality worldwide. Compelling evidence suggests that long non-coding RNA (lncRNAs) can control carcinogenesis by regulating various aspects of cell biology. However, limited number of CRC-related lncRNAs has been well characterized. Read More

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November 2018

Fe3O4-solamargine induces apoptosis and inhibits metastasis of pancreatic cancer cells.

Int J Oncol 2018 Nov 19. Epub 2018 Nov 19.

Department of Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, P.R. China.

Fe3O4-magnetic liposome (MLP) can deliver drugs to target tissues and can increase drug efficacy. The present study aimed to investigate the effects of solamargine (SM) and Fe3O4-SM in pancreatic cancer (PC). Cell viability was detected using a Cell Counting kit‑8 assay. Read More

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November 2018
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Conventional and emerging roles of the energy sensor Snf1/AMPK in .

Microb Cell 2018 Sep 29;5(11):482-494. Epub 2018 Sep 29.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.

All proliferating cells need to match metabolism, growth and cell cycle progression with nutrient availability to guarantee cell viability in spite of a changing environment. In yeast, a signaling pathway centered on the effector kinase Snf1 is required to adapt to nutrient limitation and to utilize alternative carbon sources, such as sucrose and ethanol. Snf1 shares evolutionary conserved functions with the AMP-activated Kinase (AMPK) in higher eukaryotes which, activated by energy depletion, stimulates catabolic processes and, at the same time, inhibits anabolism. Read More

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September 2018
3 Reads