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Front Endocrinol (Lausanne) 2022 19;13:852661. Epub 2022 May 19.

Research Group on Human Fertility, International Scientific Institute "Paul VI", Rome, Italy.

Testosterone is essential to maintain qualitative spermatogenesis. Nonetheless, no studies have been yet performed in humans to analyze the testosterone-mediated expression of sperm proteins and their importance in reproduction. Thus, this study aimed to identify sperm protein alterations in male hypogonadism using proteomic profiling. Read More

Front Endocrinol (Lausanne) 2022 19;13:753416. Epub 2022 May 19.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Recurrent implantation failure (RIF) is a disease associated with endometrial receptivity dysfunction. Retinoic acid receptor alpha (RARα) is an important protein in many biological processes, such as differentiation and development. However, the exact underlying mechanism whereby RARα affects RIF remains unknown. Read More

Endocrinol Diabetes Nutr (Engl Ed) 2022 Apr;69(4):279-288

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Low prolactin levels have been found to impair libido and arousal, as well as to reduce wellbeing in young women.

Objective: The aim of this study was to investigate whether drug-induced hypoprolactinaemia affects male sexual function and depressive symptoms.

Methods: The study population consisted of three groups of young and middle-aged men. Read More

Brain Inj 2022 Apr 4;36(5):607-619. Epub 2022 May 4.

Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Primary Objectives: Determine if an abnormal preliminary neuroendocrine disorder (NED) blood test screen is associated with mild TBI (mTBI) history or post-concussiveclinical features.

Research Design: Observational.

Methods: Among 1,520 participants with military combatexposure, we measured randomly timed serum levels of insulin-likegrowth factor-1, thyroid stimulating hormone (TSH), and total testosterone as a preliminary NED screen. Read More

Mol Reprod Dev 2022 05 26;89(5-6):256-268. Epub 2022 Apr 26.

Department of Reproductive Endocrinology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Decidualization is an essential process for embryo implantation and maintenance of pregnancy, and abnormal decidualization contributed to several pregnancy disorders like a miscarriage. The objective of this study was to explore the regulation and function of CD55 in human decidualization. By immunohistochemical staining, it was found that CD55 expression was higher in first-trimester decidua than in the endometrium. Read More

J Clin Res Pediatr Endocrinol 2022 Apr 25. Epub 2022 Apr 25.

Istanbul University, Istanbul Faculty of Medicine, Department of Pediatric Endocrinology.

deficiency is a rare X-linked condition characterized by central hypothyroidism (CeH) and a wide variety of other clinical features with variable prevalence, including a delayed pubertal testosterone rise and growth spurt in contrast to normal or accelerated testicular growth, and adult macroorchidism with relatively low serum testosterone concentrations. Other features include increased waist circumference, attention deficit, prolactin deficiency and transient partial growth hormone (GH) deficiency in childhood in contrast to an increased GH secretion in adulthood. Patients with this disorder are not detected if neonatal screening programs are based on thyroid-stimulating hormone (TSH) concentrations. Read More

Genes (Basel) 2022 04 8;13(4). Epub 2022 Apr 8.

Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.

Pathogenic variants within the gene encoding the pituitary-specific transcription factor, POU class 1 homeobox 1 (), are associated with combined pituitary hormone deficiency (CPHD), including growth hormone, prolactin, and thyrotropin stimulating hormone deficiencies. The aim of the study was to identify genetic aetiology in 10 subjects with CPHD from four consanguineous Sudanese families. Medical history, as well as hormonal and radiological information, was obtained from participants' medical records. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2022 Apr;54(2):369-375

Department of Medical Oncolo1. Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing 100191, China.

Pituitary immune-related adverse events induced by programmed cell death protein 1 inhibitors in advanced lung cancer patients: A report of 3 cases SUMMARY Programmed cell death protein 1 (PD-1) and its ligand 1 (PD-L1) have been widely used in lung cancer treatment, but their immune-related adverse events (irAEs) require intensive attention. Pituitary irAEs, including hypophysitis and hypopituitarism, are commonly induced by cytotoxic T lymphocyte antigen 4 inhibitors, but rarely by PD-1/PD-L1 inhibitors. Isolated adrenocorticotropic hormone(ACTH) deficiency (IAD) is a special subtype of pituitary irAEs, without any other pituitary hormone dysfunction, and with no enlargement of pituitary gland, either. Read More

J Psychiatr Res 2022 Jul 8;151:25-29. Epub 2022 Apr 8.

Department of Psychiatry, University of Maryland School of Medicine, USA. Electronic address:

Schizophrenia is a severe mental disorder with various medical comorbidities and early mortality. Hyperprolactinemia is common in women and its impact on sexual function, galactorrhea and amenorrhea is well known. This paper evaluates the risk of 25-hydroxy vitamin D deficiency and other metabolic related laboratory abnormalities in women with schizophrenia having hyperprolactinemia (N = 43). Read More

AACE Clin Case Rep 2022 Mar-Apr;8(2):58-64. Epub 2021 Oct 20.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Camurati-Engelmann disease (CED) is a rare bone dysplasia characterized by diffuse diaphyseal osteosclerosis. Skull base involvement in CED can result in hypopituitarism but is seldom reported. Our objective was to report a patient with acquired hypopituitarism due to CED and assess the management challenges. Read More

J Vet Med Sci 2022 May 5;84(5):680-688. Epub 2022 Apr 5.

Laboratory of Veterinary Biochemistry, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan.

Spontaneous dwarf rat (SDR) is a primary experimental animal model for the study of pituitary dwarfism with a point mutation in the Gh gene encoding growth hormone (GH). In previous studies, SDR has been reported to be associated with the GH deficiency as well as combined hormone deficiencies, the cause of which is unknown. In this study, we focused on the characteristics of pituitary stem/progenitor cell populations, which are a source of hormone-producing cells, in SDR. Read More

J Endocrinol Invest 2022 Apr 2. Epub 2022 Apr 2.

Department of Clinical and Molecular Medicine, University "Sapienza" of Rome, Sant'Andrea Hospital, Via di Grottarossa 1038, 00189, Rome, Italy.

Purpose: The aim of this study was to evaluate in a population of patients with erectile dysfunction (ED): (a) the prevalence of a previously unknown endocrine/glycemic disorders; (b) the correlation between ED severity and endocrine/glycemic disorders.

Methods: 1332 patients referred for ED from 2013 to 2020 were included. The ED diagnosis was made using the International-Erectile-Function-Index-5 questionnaire. Read More

Front Surg 2022 14;9:845273. Epub 2022 Mar 14.

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Craniopharyngioma (CP) with tumoral hemorrhage is a very rare syndrome presenting with various manifestation and unfavorable outcomes. The current retrospective study was performed to summarize the clinical features of CP with tumoral hemorrhage.

Methods: In this study, 185 patients with pathological diagnosis of CP (18 patients with hemorrhage) were enrolled. Read More

Horm Res Paediatr 2022 Mar 29. Epub 2022 Mar 29.

Introduction Central congenital hypothyroidism (CCH) is a rare disorder that can be caused by X-linked mutations in the immunoglobulin superfamily member 1 (IGSF1) gene. Here, we describe four familial cases with a variable presentation due to a novel IGSF1 pathogenic variant. Case presentation In the index case, investigation at birth of suspected brain-lung-thyroid syndrome surprisingly revealed a central hypothyroidism. Read More

Dev Psychobiol 2022 03;64(3):e22264

Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Elucidating the mechanisms underlying nurturing and neglect behaviors is meaningful but challenging. Recently, we found that CIN85-deficient mice had reduced pituitary hormone prolactin secretion during late pregnancy, and their pups later showed an inhibited nurturing behavior. To examine whether this phenomenon could be reproduced in normal mice and not just CIN85-deficient mice, we investigated the nurturing behavior of offspring born to mothers whose blood prolactin levels had been reduced by bromocriptine administration during late pregnancy. Read More

Hormones (Athens) 2022 Jun 10;21(2):323-327. Epub 2022 Feb 10.

Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Thivon & Levadeias Str., 11527, Athens, Greece.

Background: Giant prolactinomas are rare in childhood and adolescence and represent a challenge in diagnosis and management.

Case Presentation: A 15.7-year-old male adolescent presented with short stature and delayed puberty. Read More

Clin Rheumatol 2022 Apr 22;41(4):1087-1093. Epub 2022 Jan 22.

Department of Histology and Embryology, Shantou University Medical College, Shantou, 515041, Guangdong Province, China.

Introduction: Systemic lupus erythematosus (SLE) is a common autoimmune disease with significant gender bias in women, and sex hormones are considered to play an important role in the regulation of immune activity. The CD45 isoforms generated through alternative splicing of mRNA identify different functional status of lymphocytes and also are suggested as a biomarker for assessing the progression of SLE, while the modulation of CD45 expression in SLE patients is not clear.

Methods: In this study, the peripheral blood sera of 46 SLE patients and 15 health individuals were collected for detecting the levels of sex hormones and immune associated factors. Read More

Zhongguo Zhen Jiu 2021 Dec;41(12):1325-30

Department of Reproductive Medicine, Henan Provincial Hospital of TCM, Zhengzhou 450002, China.

Objective: To observe the clinical therapeutic effect on functional erectile dysfunction (FED) of kidney deficiency and liver stagnation treated by moxibustion and decoction.

Methods: A total of 120 patients with FED were randomized into an observation group (60 cases, 2 cases dropped off) and a control group (60 cases, 4 cases dropped off). In the control group, the patients were treated with oral decoction (, , , , etc. Read More

BMC Cancer 2021 Dec 18;21(1):1346. Epub 2021 Dec 18.

Department of radiation therapy, Institut de Cancérologie de Lorraine, 6 avenue de Bourgogne, 54519, Vandoeuvre Les Nancy, France.

Background: Cranial irradiation represents one of the first line treatment proposed in skull base meningiomas. While cranial irradiation is associated with a high risk of secondary hypopituitarism, few studies focused on the specific location of skull base meningiomas.

Methods: Fifty-two adults receiving photon-beam therapy for skull base meningiomas between 2003 and 2014 in our Institution were included. Read More

Endocrinology 2022 03;163(3)

Department of Animal Science, University of California, Davis, Davis, California 95616, USA.

Successful lactation and the risk for developing breast cancer depend on growth and differentiation of the mammary gland (MG) epithelium that is regulated by ovarian steroids (17β-estradiol [E] and progesterone [P]) and pituitary-derived prolactin (PRL). Given that the MG of pigs share histomorphogenic features present in the normal human breast, we sought to define the transcriptional responses within the MG of pigs following exposure to all combinations of these hormones. Hormone-ablated female pigs were administered combinations of E, medroxyprogesterone 17-acetate (source of P), and either haloperidol (to induce PRL) or 2-bromo-α-ergocryptine. Read More

Genet Med 2022 02 30;24(2):384-397. Epub 2021 Nov 30.

Genetics and Genomic Medicine Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom; South Australian Health and Medical Research Institute (SAHMRI), The University of Adelaide, Adelaide, South Australia, Australia; Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children, London, United Kingdom. Electronic address:

Purpose: We aimed to investigate the molecular basis underlying a novel phenotype including hypopituitarism associated with primary ovarian insufficiency.

Methods: We used next-generation sequencing to identify variants in all pedigrees. Expression of Rnpc3/RNPC3 was analyzed by in situ hybridization on murine/human embryonic sections. Read More

Front Pharmacol 2021 18;12:779962. Epub 2021 Nov 18.

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech.

Obesity and type 2 diabetes mellitus (T2DM) are preconditions for the development of metabolic syndrome, which is reaching pandemic levels worldwide, but there are still only a few anti-obesity drugs available. One of the promising tools for the treatment of obesity and related metabolic complications is anorexigenic peptides, such as prolactin-releasing peptide (PrRP). PrRP is a centrally acting neuropeptide involved in food intake and body weight (BW) regulation. Read More

Cancers (Basel) 2021 Oct 26;13(21). Epub 2021 Oct 26.

Department of Internal Medicine, Institute of Endocrine Research, Yonsei University College of Medicine, Seoul 03722, Korea.

Predicting dopamine agonist resistance in patients with macroprolactinoma is essential for clinicians to prevent treatment failure and subsequent complications such as medication-induced cerebrospinal fluid (CSF) rhinorrhea. We evaluated the features of patients with cabergoline resistance and CSF rhinorrhea in patients with prolactinomas with prolactin levels ≥1000 ng/mL. A total of 140 patients who were newly diagnosed with prolactinoma secreting only prolactin ≥1000 ng/mL and treated with cabergoline for the first time were included in this study. Read More

Int J Mol Sci 2021 Oct 28;22(21). Epub 2021 Oct 28.

Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.

Selenophosphate synthetase 1 (SEPHS1) plays an essential role in cell growth and survival. However, the underlying molecular mechanisms remain unclear. In the present study, the pathways regulated by SEPHS1 during gastrulation were determined by bioinformatical analyses and experimental verification using systemic knockout mice targeting . Read More

Front Endocrinol (Lausanne) 2021 7;12:748725. Epub 2021 Oct 7.

Department of Neurosurgery, The Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China.

Objective: No accurate predictive models were identified for hormonal prognosis in non-functioning pituitary adenoma (NFPA). This study aimed to develop machine learning (ML) models to facilitate the prognostic assessment of pituitary hormonal outcomes after surgery.

Methods: A total of 215 male patients with NFPA, who underwent surgery in four medical centers from 2015 to 2021, were retrospectively reviewed. Read More

Eur J Endocrinol 2021 Oct 21;185(6):783-791. Epub 2021 Oct 21.

Department of Neurosurgery, Foch Hospital, Suresnes, France.

Objective: Microprolactinomas are currently treated with dopamine agonists. Outcome information on microprolactinoma patients treated by surgery is limited. This study reports the first large series of consecutive non-invasive microprolactinoma patients treated by pituitary surgery and evaluates the efficiency and safety of this treatment. Read More

Cell Death Dis 2021 09 25;12(10):879. Epub 2021 Sep 25.

Department of Laboratory Animal Science, Fudan University, Shanghai, China.

Dopaminergic (DA) neurons in the arcuate nucleus (ARC) of the hypothalamus play essential roles in the secretion of prolactin and the regulation of energy homeostasis. However, the gene regulatory network responsible for the development of the DA neurons remains poorly understood. Here we report that the transcription factor special AT-rich binding protein 2 (Satb2) is required for the development of ARC DA neurons. Read More

JIMD Rep 2021 Sep 29;61(1):48-51. Epub 2021 Jun 29.

Division of Metabolic Diseases, Department of Medicine-DIMED, University Hospital University of Padova Padova Italy.

We report the case of a 22-year-old man with a diagnosis of dihydropteridine reductase (DHPR) deficiency who progressively developed movement disorders and epilepsy. Despite L-Dopa supplementation the patient continued to show high prolactin levels, with a discrepancy between the neurological clinical picture and the hormonal biochemical levels. For this reason, other potential causes were ruled out by performing a cerebral magnetic resonance imaging, which demonstrated a solid lesion in the pituitary gland strongly suggestive of a prolactinoma. Read More

Foods 2021 Aug 12;10(8). Epub 2021 Aug 12.

College of Food Science, South China Agricultural University, Guangzhou 510642, China.

The function of Baroni (daylily) on promoting lactation is reported in several ancient Chinese medicine books. However, nowadays, there is no conclusive data to support this statement. In this study, we investigated the effect of Baroni extract (HCE) on lactation insufficiency in chronic unpredictable mild stress (CUMS) dams and further explored the mechanism and functional components through network pharmacology. Read More