1,788 results match your criteria Prolactin Deficiency


Clinical Factors Affecting the Therapeutic Efficacy of Evening Primrose Oil on Mastalgia.

Ann Surg Oncol 2020 Aug 3. Epub 2020 Aug 3.

Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA.

Background: Saturated fatty acid esters may cause mastalgia via hypersensitivity of breast epithelium to circulating hormones. Evening primrose oil (EPO) may restore the saturated/unsaturated fatty acid balance and decrease sensitivity to steroidal hormones or prolactin. Conflicting results exist regarding EPO treatment for mastalgia. Read More

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http://dx.doi.org/10.1245/s10434-020-08949-xDOI Listing

Genome-wide association study identifies variants associated with hair length in Brangus cattle.

Anim Genet 2020 Jun 16. Epub 2020 Jun 16.

Animal Sciences, University of Florida, 2250 Shealy Dr, Gainesville, FL, 32608, USA.

Thermal stress limits beef cattle production and a shorter hair coat is a key thermoregulative adaptation that allows cattle to lose heat more efficiently. The objective of this study was to identify genetic variants associated with the length of the undercoat and topcoat of cattle utilizing 1456 Brangus heifers genotyped with the Bovine GGP F250 array. Seven SNPs in the PCCA gene were significantly associated with undercoat length. Read More

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http://dx.doi.org/10.1111/age.12970DOI Listing

On maternal Post-Partum/Natal depression. A global underrecognized problem and the need for better Treatment strategies.

Psychiatry Res 2020 May 31;290:113163. Epub 2020 May 31.

Independent Scholar, San Diego, San Diego, CA, 92110, United States. Electronic address:

Background: Maternal Postpartum (PPD) or Postnatal Depression (PND) is believed to be the commonest medical complication postpartum. Evidence suggests a significantly higher prevalence of the disease compared to the often reported 10-15%.

Method: Studies were identified by accessing several databases including PubMed/Medline, PubMed Central, EBSCO, and PsycINFO. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113163DOI Listing

Vaccarin promotes proliferation of and milk synthesis in bovine mammary epithelial cells through the Prl receptor-PI3K signaling pathway.

Eur J Pharmacol 2020 Aug 25;880:173190. Epub 2020 May 25.

School of Animal Science, Yangtze University, Jingzhou, 434023, China. Electronic address:

Semen Vaccariae, the seed of Vaccaria segetalis, is traditionally used in East Asian countries for the treatment of breast milk deficiency, but the underlying molecular mechanism has not been discovered yet. The present study assessed the stimulatory effect of vaccarin, one of the major constituents of Semen Vaccariae, on proliferation of and milk synthesis in bovine mammary epithelial cells (BMECs) and explored the corresponding molecular mechanism. Vaccarin affected cell proliferation and milk fat and protein synthesis in a concentration-dependent manner, with the best stimulatory effects at 0. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173190DOI Listing

Safety, tolerability, pharmacokinetics, and pharmacodynamics of macimorelin in healthy adults: Results of a single-dose, randomized controlled study.

Growth Horm IGF Res 2020 Jun 15;52:101321. Epub 2020 Apr 15.

Novo Nordisk Inc., Plainsboro, New Jersey, United States.

Objective: Macimorelin is an orally active ghrelin receptor agonist indicated for the diagnosis of adult growth hormone (GH) deficiency in the United States. This phase 1 study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of macimorelin (including a supratherapeutic dose to be used in a thorough QT trial) in healthy adults.

Design: Participants were randomized to receive macimorelin 0. Read More

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http://dx.doi.org/10.1016/j.ghir.2020.101321DOI Listing

Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease.

Hum Mol Genet 2020 Jun;29(10):1648-1657

Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.

Combined pituitary hormone deficiency (CPHD) is a genetically heterogeneous disorder caused by mutations in over 30 genes. The loss-of-function mutations in many of these genes, including orthodenticle homeobox 2 (OTX2), can present with a broad range of clinical symptoms, which provides a challenge for predicting phenotype from genotype. Another challenge in human genetics is functional evaluation of rare genetic variants that are predicted to be deleterious. Read More

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http://dx.doi.org/10.1093/hmg/ddaa064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322578PMC

Non-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

División Endocrinología, Hospital General de Agudos Dr. Carlos G. Durand, Buenos Aires, Argentina.

The usual clinical presentation of non-functioning pituitary adenoma (NFPA) consists of symptoms of mass effect and hypopituitarism. NFPA is a rare condition in young women and an uncommon complication during pregnancy. We present the outcome of three patients with NFPA during pregnancy. Read More

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http://dx.doi.org/10.20945/2359-3997000000232DOI Listing

Frequency of Hypogonadism in Type 2 Diabetes Mellitus Patients with and without Coronary Artery Disease.

Cureus 2019 Dec 29;11(12):e6500. Epub 2019 Dec 29.

Medicine, Allama Iqbal Medical College/Jinnah Hospital, Lahore, PAK.

Introduction Hypogonadism is characterized by clinical and biochemical evidence of testosterone deficiency. Low testosterone levels have been reported in patients with type 2 diabetes mellitus (T2DM), which can predispose to coronary artery disease (CAD). It has been proposed that diabetic men with proven CAD have lower androgen levels than patients with normal coronary arteriograms. Read More

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http://dx.doi.org/10.7759/cureus.6500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988492PMC
December 2019

Thiamine deficiency and oxidative stress induced by prolonged metronidazole therapy can explain its side effects of neurotoxicity and infertility in experimental animals: Effect of grapefruit co-therapy.

Hum Exp Toxicol 2020 Jun 30;39(6):834-847. Epub 2020 Jan 30.

Department of Medical Pharmacology, Faculty of Medicine, South Valley University, Qena, Egypt.

We aimed to explore the possible neurotoxicity and infertility mechanisms of prolonged metronidazole (MTZ) use and the effects of antioxidant grapefruit (GP) co-therapy on MTZ-induced complications. Sixty male albino Wistar rats were divided into four groups ( = 15 each). Group I (control group) received 1% dimethyl sulfoxide (27 ml/ kg/day), group II (MTZ group) received MTZ (400 mg/kg/day), group III (MTZ + GP) received MTZ (400 mg/kg/ day) plus GP juice (27 ml/kg/ day) and group IV (GP group) received GP juice (27 ml/kg) for 60 days. Read More

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http://dx.doi.org/10.1177/0960327119867755DOI Listing

Sex Hormone Profile in Pubertal Boys With Gynecomastia and Pseudogynecomastia.

J Clin Endocrinol Metab 2020 Apr;105(4)

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Schleswig-Holstein, Campus Kiel/Christian-Albrechts University of Kiel, Kiel, Germany.

Content: Gynecomastia (defined by proliferation of glandular elements) and pseudogynecomastia (defined by adipose tissue) are frequent in pubertal boys. An association with sex hormones and the growth hormone axis has been discussed.

Objective: The objective of this work is to compare sex hormones, insulin-like growth factor 1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP-3) between boys with gynecomastia and pseudogynecomastia (separation by ultrasound). Read More

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http://dx.doi.org/10.1210/clinem/dgaa044DOI Listing

Neuroendocrinology and neurobiology of sebaceous glands.

Biol Rev Camb Philos Soc 2020 Jun 22;95(3):592-624. Epub 2020 Jan 22.

Centre for Dermatology, School of Biological Sciences, University of Manchester, and NIHR Manchester Biomedical Research Centre, Stopford Building, Oxford Road, Manchester, M13 9PT, U.K.

The nervous system communicates with peripheral tissues through nerve fibres and the systemic release of hypothalamic and pituitary neurohormones. Communication between the nervous system and the largest human organ, skin, has traditionally received little attention. In particular, the neuro-regulation of sebaceous glands (SGs), a major skin appendage, is rarely considered. Read More

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http://dx.doi.org/10.1111/brv.12579DOI Listing

AN UNEXPECTED COMBINATION OF PROLACTINOMA AND SEPTO-OPTIC DYSPLASIA.

AACE Clin Case Rep 2019 Sep-Oct;5(5):e282-e286. Epub 2019 Jun 7.

Objective: To describe the unusual finding of pituitary adenoma in a patient with septo-optic dysplasia (SOD).

Methods: We describe the clinical presentation, biochemical and radiological evaluation, treatment, and outcomes of a patient with macroprolactinoma and previously undiagnosed SOD.

Results: A 41-year-old woman with optic nerve hypoplasia and growth hormone deficiency presented with new-onset galactorrhea, polyuria, and polydipsia. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876952PMC

CYSTIC PROLACTINOMA: A SURGICAL DISEASE?

AACE Clin Case Rep 2019 Jan-Feb;5(1):e66-e69. Epub 2019 Jan 30.

Objective: Since the advent of dopamine agonists, prolactinomas have been primarily treated medically. However, studies show conflicting data on whether these agents are as effective as surgery for predominantly cystic prolactinomas. We present a case of a patient with a cystic prolactinoma for which surgery was selected as first-line therapy. Read More

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http://dx.doi.org/10.4158/ACCR-2018-0267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876970PMC
January 2019

Mutations within The Transcription Factor in a Cohort of Turkish Patients with Combined Pituitary Hormone Deficiency

J Clin Res Pediatr Endocrinol 2020 Jan 17. Epub 2020 Jan 17.

Çukurova University Medical Faculty, Department of Pediatrics, Division of Pediatric Endocrinology, Adana, Turkey

Objective: Mutations of genes encoding transcription factors which play important roles in pituitary morphogenesis, differentiation and maturation lead to combined pituitary hormone deficiency (CPHD). gene mutations are reported as the most frequent genetic aetiology of CHPD. The aim of this study is to describe phenotype of Turkish CPHD patients and define frequency of mutations. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2020.2019.0191DOI Listing
January 2020

Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review.

Int J Endocrinol 2019 18;2019:5382640. Epub 2019 Dec 18.

Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

Background: IgG4-related hypophysitis (IgG4-RH) is a rare disease, and its prevalence remains unclear. In recent years, an increasing number of cases have been reported because of the increasing recognition of this disease. We aimed to summarize case reports of IgG4-RH and outline the clinical features and outcomes. Read More

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http://dx.doi.org/10.1155/2019/5382640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935800PMC
December 2019

Interrelationship between oxidative stress, DNA damage and cancer risk in diabetes (Type 2) in Riyadh, KSA.

Saudi J Biol Sci 2020 Jan 24;27(1):177-183. Epub 2019 Jun 24.

Central Military Laboratory & Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Type 2 Diabetes Mellitus (T2DM) is the most widely known type of disorder of the endocrine system marked by hyperglycemia resulting either due to deficiency of insulin and or resistance. Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in the pathophysiology underlying T2DM. Besides, oxidative stress can result in DNA damage leading to high cancer risk. Read More

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http://dx.doi.org/10.1016/j.sjbs.2019.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933234PMC
January 2020
0.741 Impact Factor

Synergistic effect of leptin and lipidized PrRP on metabolic pathways in ob/ob mice.

J Mol Endocrinol 2020 02;64(2):77-90

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

Lack of leptin production in ob/ob mice results in obesity and prediabetes that could be partly reversed by leptin supplementation. In the hypothalamus, leptin supports the production of prolactin-releasing peptide (PrRP), an anorexigenic neuropeptide synthesized and active in the brain. In our recent studies, the palmitoylated PrRP analog palm11-PrRP31 showed a central anorexigenic effect after peripheral administration. Read More

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http://dx.doi.org/10.1530/JME-19-0188DOI Listing
February 2020

A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Kang-Bai-Ling for Treatment of Vitiligo.

Evid Based Complement Alternat Med 2019 3;2019:3053458. Epub 2019 Nov 3.

Department of Dermatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian 223300, China.

Background: Kang-bai-ling (KBL), a Chinese patent medicine, has been demonstrated as an effective therapy for vitiligo in China. However, the pharmacological mechanisms of KBL have not been completely elucidated.

Methods: In this study, the potential multicomponent, multitarget, and multipathway mechanism of KBL against vitiligo was clarified by using network pharmacology-based strategy. Read More

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http://dx.doi.org/10.1155/2019/3053458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875403PMC
November 2019

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function.

Front Endocrinol (Lausanne) 2019 6;10:765. Epub 2019 Nov 6.

HILIFE, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) form a family of atypical growth factors discovered for their neuroprotective properties in the central nervous system (CNS) in animal models of neurodegenerative diseases. Although their mechanism of protective action still remains unclear, it has been suggested that both MANF and CDNF promote cell survival through regulating the unfolded protein response (UPR), thereby relieving endoplasmic reticulum (ER) stress. Recent studies identified MANF for its emerging roles in metabolic function, inflammation and pancreatic β-cells. Read More

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http://dx.doi.org/10.3389/fendo.2019.00765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851024PMC
November 2019

Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2.

Am J Obstet Gynecol 2020 04 15;222(4):376.e1-376.e17. Epub 2019 Nov 15.

Igenomix Foundation-Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain; Department of Obstetrics and Gynecology, School of Medicine, University of Valencia, Valencia, Spain; Department of Obstetrics and Gynecology, BIDMC, Harvard University, Boston, MA.

Background: Decidualization defects in the endometrium have been demonstrated at the time of delivery in women with severe preeclampsia and to linger for years, which suggests a maternal contribution to the pathogenesis of this condition. Global transcriptional profiling reveals alterations in gene expression, which includes down-regulation of Annexin A2 in severe preeclampsia patients with decidualization resistance.

Objective: We investigated the functional role of Annexin A2 deficiency during endometrial decidualization and its potential contribution to shallow trophoblast invasion during implantation and subsequent placentation using in vitro and in vivo modeling. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.11.1250DOI Listing

Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus.

Biochem Biophys Res Commun 2020 01 31;521(2):521-526. Epub 2019 Oct 31.

Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki, 889-2192, Japan. Electronic address:

Neuromedin U (NMU) has a precursor that contains one additional peptide consisting of 33 or 36 amino acid residues. Recently, we identified this second peptide from rat brain and designated it neuromedin U precursor-related peptide (NURP), showing it to stimulate prolactin release from the pituitary when injected via the intracerebroventricular (icv) route. Here, we examined whether NMU, like NURP, also stimulates prolactin release. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.10.156DOI Listing
January 2020

Prevalence of growth hormone deficiency in middle-age adults recovering from stroke.

Brain Inj 2020 29;34(2):276-280. Epub 2019 Oct 29.

Centre for Neuro Skills, Bakersfield, CA, USA.

: The prevalence of chronic growth hormone deficiency (GHD) and its association with other hormonal deficiencies was determined in middle-aged patients post-stroke with and without consideration of body mass index (BMI).: Clinical records were reviewed to determine pituitary function at least 3 months post-stroke. Patients with a history of endocrine anomalies were excluded. Read More

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http://dx.doi.org/10.1080/02699052.2019.1682195DOI Listing
October 2019
1 Read

Predictors of hypopituitarism due to vasculotoxic snake bite with acute kidney injury.

Pituitary 2019 Dec;22(6):594-600

Dept. of Endocrinology, IPGME&R, Kolkata, 700020, India.

Purpose: Hypopituitarism frequently develops following vasculotoxic snake bite complicated by acute kidney injury (AKI). Well defined prospective studies of prevalence of hypopituitarism and its predictors in vasculotoxic snake bites complicated by AKI are unavailable.

Methods: Fifty-one consecutive patients of AKI following vasculotoxic snake bite were evaluated for various clinical/biochemical parameters (including Free T4, TSH, Cortisol, ACTH, total testosterone, FSH, LH, prolactin, and IGF-1). Read More

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http://dx.doi.org/10.1007/s11102-019-00990-8DOI Listing
December 2019
3 Reads

Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinson's disease model mice.

Sci Rep 2019 09 24;9(1):13768. Epub 2019 Sep 24.

Department of Pharmacology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Accumulating evidence have shown the association of Parkinson's disease (PD) with osteoporosis. Bone loss in PD patients, considered to be multifactorial and a result of motor disfunction, is a hallmark symptom that causes immobility and decreased muscle strength, as well as malnutrition and medication. However, no known experimental evidence has been presented showing deleterious effects of anti-PD drugs on bone or involvement of dopaminergic degeneration in bone metabolism. Read More

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http://dx.doi.org/10.1038/s41598-019-50336-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760231PMC
September 2019
1 Read

Autoimmune Pituitary Disease: New Concepts With Clinical Implications.

Endocr Rev 2020 Apr;41(2)

Division of Diabetes and Endocrinology Kobe University Graduate School of Medicine, Kobe, Japan.

Some endocrine disorders, including hypophysitis and isolated adrenocorticotropic hormone (ACTH) deficiency, are caused by an autoimmune response to endocrine organs. Although the pathogenesis of some autoimmune endocrine diseases has been elucidated, it remains obscure for most. Anti-PIT-1 hypophysitis (anti-PIT-1 antibody syndrome) is a newly described pituitary autoimmune disease characterized by acquired and specific growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies. Read More

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http://dx.doi.org/10.1210/endrev/bnz003DOI Listing
April 2020
4 Reads

Genetics of Congenital Isolated TSH Deficiency: Mutation Screening of the Known Causative Genes and a Literature Review.

J Clin Endocrinol Metab 2019 12;104(12):6229-6237

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Context: Congenital isolated TSH deficiency (i-TSHD) is a rare form of congenital hypothyroidism. Five genes (IGSF1, IRS4, TBL1X, TRHR, and TSHB) responsible for the disease have been identified, although their relative frequencies and hypothalamic/pituitary unit phenotypes have remained to be clarified.

Objectives: To define the relative frequencies and hypothalamic/pituitary unit phenotypes of congenital i-TSHD resulting from single gene mutations. Read More

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http://dx.doi.org/10.1210/jc.2019-00657DOI Listing
December 2019
2 Reads

Effects of CPAP on Testosterone Levels in Patients With Obstructive Sleep Apnea: A Meta-Analysis Study.

Front Endocrinol (Lausanne) 2019 21;10:551. Epub 2019 Aug 21.

Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.

Obstructive sleep apnea (OSA) represents a frequent complication among patients with obesity and has been associated with neuroendocrine changes, including hypogonadism. We conducted a systematic review and meta-analysis to evaluate the effects of continuous positive airway pressure (CPAP) on testosterone and gonadotropins in male patients with OSA. The review was registered on PROSPERO (CRD42018103164). Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00551
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http://dx.doi.org/10.3389/fendo.2019.00551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712440PMC
August 2019
2 Reads

Hypoprolactinemia as a Clue to Diagnosis of Mild Central Hypothyroidism due to Deficiency

J Clin Res Pediatr Endocrinol 2020 06 26;12(2):218-222. Epub 2019 Aug 26.

National and Kapodistrian University of Athens, “Attikon” University Hospital, Third Department of Pediatrics, Athens, Greece

Loss-of-function mutations of are an X-linked cause of central hypothyroidism (CeH) and hypoprolactinemia. A boy who is now 15.2 years old presented at the age of 7. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2019.0085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291406PMC
June 2020
4 Reads

Physical changes, laboratory parameters, and bone mineral density during testosterone treatment in adolescents with gender dysphoria.

J Sex Med 2019 09 9;16(9):1459-1468. Epub 2019 Aug 9.

Department of Pediatrics, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address:

Introduction: Current treatment guidelines for adolescents with gender dysphoria recommend therapy with gonadotropin-releasing hormone agonists (GnRHa) and testosterone in transgender males. However, most evidence on the safety and efficacy of testosterone is based on studies in adults.

Aim: This study aimed to investigate the efficacy and safety of testosterone treatment in transgender adolescents. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.06.014DOI Listing
September 2019
4 Reads

Prolactin Promotes Fibrosis and Pancreatic Cancer Progression.

Cancer Res 2019 10 8;79(20):5316-5327. Epub 2019 Aug 8.

Department of Surgery, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.

Pancreatic ductal adenocarcinoma (PDAC) is associated with significant fibrosis. Recent findings have highlighted the profibrotic activity of tissue-resident macrophages in the pancreatic cancer microenvironment. Here, we show that neoplastic pancreatic epithelium, as well as a subset of tissue-resident macrophages, expresses the prolactin-receptor (PRLR). Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801092PMC
October 2019
2 Reads

Association of Vitamin D Status with Metabolic Syndrome and its Components in Polycystic Ovary Syndrome.

Mymensingh Med J 2019 Jul;28(3):547-552

Dr Abul Bashar Mohammad Kamrul Hasan, Assistant Registrar, Department of Endocrinology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail:

Metabolic syndrome (Met-S) and vitamin D deficiency (VDD) are common in polycystic ovary syndrome (PCOS) and hypovitaminosis D in PCOS was found to be associated with Met-S and its components. This cross-sectional study evaluated 110 newly diagnosed women with PCOS randomly recruited from the Endocrinology outpatient department of Mymensingh Medical College Hospital, Bangladesh from January to December 2018 to assess vitamin D status and to explore the relationship of vitamin D status with Met-S and its components. Met-S was diagnosed by using the International Diabetes Federation (IDF) criteria applicable for South Asian women. Read More

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July 2019
9 Reads

The benefit and risk of stereotactic radiosurgery for prolactinomas: an international multicenter cohort study.

J Neurosurg 2019 Aug 2:1-10. Epub 2019 Aug 2.

1Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia.

Objective: The most common functioning pituitary adenoma is prolactinoma. Patients with medically refractory or residual/recurrent tumors that are not amenable to resection can be treated with stereotactic radiosurgery (SRS). The aim of this multicenter study was to evaluate the role of SRS for treating prolactinomas. Read More

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http://dx.doi.org/10.3171/2019.4.JNS183443DOI Listing
August 2019
15 Reads
3.737 Impact Factor

Extreme Short Stature and Severe Neurological Impairment in a 17-Year-Old Male With Untreated Combined Pituitary Hormone Deficiency Due to Mutation.

Front Endocrinol (Lausanne) 2019 27;10:381. Epub 2019 Jun 27.

Ha'Emek Medical Center, Pediatric Endocrine Institute, Afula, Israel.

POU1F1 is an essential transcription factor for the differentiation, proliferation and survival of somatotrophs, lactotrophs, and thyrotrophs. Mutations in the gene are characterized by growth hormone (GH), thyrotropin, and prolactin deficiencies, commonly presenting with growth retardation and central hypothyroidism. Since the first report in 1992, more than 25 mutations have been identified in . Read More

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http://dx.doi.org/10.3389/fendo.2019.00381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610292PMC
June 2019
3 Reads

Microarray analysis of gene expression in the diacylglycerol kinase η knockout mouse brain.

Biochem Biophys Rep 2019 Sep 25;19:100660. Epub 2019 Jun 25.

Department of Chemistry, Graduate School of Science, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.

We have revealed that diacylglycerol kinase η (DGKη)-knockout (KO) mice display bipolar disorder (BPD) remedy-sensitive mania-like behaviors. However, the molecular mechanisms causing the mania-like abnormal behaviors remain unclear. In the present study, microarray analysis was performed to determine global changes in gene expression in the DGKη-KO mouse brain. Read More

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http://dx.doi.org/10.1016/j.bbrep.2019.100660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597918PMC
September 2019
3 Reads

Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus.

Proc Natl Acad Sci U S A 2019 07 8;116(30):15236-15243. Epub 2019 Jul 8.

Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Germany;

Dopamine neurons of the hypothalamic arcuate nucleus (ARC) tonically inhibit the release of the protein hormone prolactin from lactotropic cells in the anterior pituitary gland and thus play a central role in prolactin homeostasis of the body. Prolactin, in turn, orchestrates numerous important biological functions such as maternal behavior, reproduction, and sexual arousal. Here, we identify the canonical transient receptor potential channel Trpc5 as an essential requirement for normal function of dopamine ARC neurons and prolactin homeostasis. Read More

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http://dx.doi.org/10.1073/pnas.1905705116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660783PMC
July 2019
3 Reads
9.809 Impact Factor

STAT5a/b Deficiency Delays, but does not Prevent, Prolactin-Driven Prostate Tumorigenesis in Mice.

Cancers (Basel) 2019 Jul 2;11(7). Epub 2019 Jul 2.

Institut Necker Enfants Malades, Inserm U1151, 75014 Paris, France.

The canonical prolactin (PRL) Signal Transducer and Activator of Transcription (STAT) 5 pathway has been suggested to contribute to human prostate tumorigenesis via an autocrine/paracrine mechanism. The probasin (Pb)-PRL transgenic mouse models this mechanism by overexpressing PRL specifically in the prostate epithelium leading to strong STAT5 activation in luminal cells. These mice exhibit hypertrophic prostates harboring various pre-neoplastic lesions that aggravate with age and accumulation of castration-resistant stem/progenitor cells. Read More

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http://dx.doi.org/10.3390/cancers11070929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678910PMC
July 2019
2 Reads

Cannabinoid-deficient Benin republic hemp (Cannabis sativa L.) improves semen parameters by reducing prolactin and enhancing anti-oxidant status.

BMC Complement Altern Med 2019 Jun 17;19(1):132. Epub 2019 Jun 17.

Department of Physiology, College of Health Sciences, University of Ilorin, Kwara, Nigeria.

Background: Nigerian Cannabis sativa (hemp) causes male gonadotoxicity by inducing hyperprolactinemia, down-regulation of hypothalamic-pituitary-testicular axis, and oxidative stress. Benin republic hemp has been preferred by illicit users in Nigeria but its effect on male fertility is not understood. This study determined and compared the compositions of Benin republic hemp ethanol extract (BHE) and Nigerian hemp. Read More

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http://dx.doi.org/10.1186/s12906-019-2541-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580547PMC
June 2019
8 Reads
2.020 Impact Factor

The relevance of ANXA5 genetic variants on male fertility.

J Assist Reprod Genet 2019 Jul 13;36(7):1355-1359. Epub 2019 Jun 13.

Centre of Reproductive Medicine and Andrology, University of Münster, Münster, Germany.

Purpose: To investigate the effect of the anticoagulation factor annexin A5 on male fertility and to provide perspective on the influence of members of the coagulation cascade on fertility.

Methods: Patients with normozoospermia and with unexplained severe oligozoospermia were retrospectively selected and their genomic DNA sequenced for the promoter region of ANXA5. The genotypes proportions and the odds ratio for carriership of the haplotype M2 were compared between the groups and population control. Read More

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http://dx.doi.org/10.1007/s10815-019-01458-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642233PMC
July 2019
5 Reads

The effect of testosterone on thyroid autoimmunity in euthyroid men with Hashimoto's thyroiditis and low testosterone levels.

J Clin Pharm Ther 2019 Oct 10;44(5):742-749. Epub 2019 Jun 10.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

What Is Known And Objective: Thyroid autoimmune diseases occur much more frequently in women than men. Unfortunately, no previous study has determined whether sex hormones produce any effect on thyroid antibody titres. The primary study aim was to assess whether exogenous testosterone affects thyroid autoimmunity in men with Hashimoto's thyroiditis and low testosterone levels. Read More

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http://dx.doi.org/10.1111/jcpt.12987DOI Listing
October 2019
22 Reads

EAA clinical practice guidelines-gynecomastia evaluation and management.

Andrology 2019 11 16;7(6):778-793. Epub 2019 May 16.

University Department of Growth and Reproduction, and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, Copenhagen, Denmark.

Background: Gynecomastia (GM) is a benign proliferation of the glandular tissue of the breast in men. It is a frequent condition with a reported prevalence of 32-65%, depending on the age and the criteria used for definition. GM of infancy and puberty are common, benign conditions resolving spontaneously in the majority of cases. Read More

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http://dx.doi.org/10.1111/andr.12636DOI Listing
November 2019
11 Reads

Prolactin in hypertensive men with androgen deficiency: an éminence grise?

Wiad Lek 2019 ;72(3):357-361

Department of Internal Diseases 2, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine.

Objective: Introduction: Considering significant gap of convincing knowledge in the field of cardiovascular effects of prolactin and its role as a stress hormone in men precise investigations of these peculiarities has become necessary. The aim of this study was to find out the relationship of prolactin concentration with parameters of arterial stiffness in hypertensive men with low testosterone.

Patients And Methods: Materials and methods: In total 83 men were examined including 27 apparently healthy individuals as the control group. Read More

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August 2019
6 Reads

Characterization of a Novel POU1F1 Mutation Identified on Screening 160 Growth Hormone Deficiency Patients.

Horm Metab Res 2019 Apr 25;51(4):248-255. Epub 2019 Apr 25.

Laboratory of Cyto-Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

The objective of the study is the functional characterization of a novel c.605delC mutation in combined pituitary hormone deficiency (CPHD) and to report the clinical and genetic details of 160 growth hormone deficiency patients. Screening of , , , , and genes by Sanger sequencing was carried out in 160 trios and 100 controls followed by characterization of the c. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0867-1026
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http://dx.doi.org/10.1055/a-0867-1026DOI Listing
April 2019
31 Reads

Normal Growth despite Combined Pituitary Hormone Deficiency.

Horm Res Paediatr 2019 25;92(2):133-142. Epub 2019 Apr 25.

Explorations Fonctionnelles et génétique endocriniennes, Hôpital Armand-Trousseau, AP-HP, Paris, France,

Background: The paradox of normal growth despite a lack of growth hormone (GH) is an unexplained phenomenon described in some pathological (sellar, suprasellar, and hypothalamic disorders) and overgrowth syndromes. It has been suggested that the paradoxical growth is due to other GH variants, GH-like moieties, prolactin, insulin, insulin-like growth factors (IGFs), and unidentified serum factors or growth mechanisms. The objective of this study was to determine the mechanism underlying this normal growth without GH. Read More

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https://www.karger.com/Article/FullText/499318
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http://dx.doi.org/10.1159/000499318DOI Listing
May 2020
36 Reads

Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice.

Mol Reprod Dev 2019 06 23;86(6):696-713. Epub 2019 Apr 23.

Institute of Life Sciences, Chongqing Medical University, Chongqing, China.

Prolactin family 7, subfamily d, member 1 (Prl7d1), a member of the expanding prolactin family, is mainly expressed in the placental junctional zone (including trophoblast giant cells and spongiotrophoblast cells) with peak expression observed at 12 days postcoitum (dpc) in mice. Previous studies have shown that PRL7D1 is a key mediator of angiogenesis in vitro; however, its physiological roles in placental development in vivo have not been characterized. To address this issue, we deleted Prl7d1 in mice and demonstrated that its absence results in reduced litter size and fertility. Read More

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http://dx.doi.org/10.1002/mrd.23148DOI Listing
June 2019
3 Reads

MANAGEMENT AND OUTCOMES OF GIANT PROLACTINOMA: A SERIES OF 71 PATIENTS.

Endocr Pract 2019 Apr;25(4):340-352

To describe outcomes of patients with giant prolactinoma (≥4 cm) and identify predictors of therapeutic response. In this retrospective study, complete biochemical and structural response were defined as prolactin (PRL) ≤25 ng/mL and no visible tumor at follow-up, respectively. Giant prolactinoma (median size, 4. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0392
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http://dx.doi.org/10.4158/EP-2018-0392DOI Listing
April 2019
25 Reads

Primary Cortisol Deficiency and Growth Hormone Deficiency in a Neonate With Hypoglycemia: Coincidence or Consequence?

J Endocr Soc 2019 Apr 20;3(4):838-846. Epub 2019 Feb 20.

Division of Pediatric Endocrinology and Diabetes, Mount Sinai Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.

Cortisol and growth hormone (GH) deficiencies are causes of neonatal hypoglycemia. When they coexist, a pituitary disorder is suspected. We present an infant with hypoglycemia in whom an ACTH receptor defect was associated with transient GH deficiency. Read More

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http://dx.doi.org/10.1210/js.2018-00386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447946PMC
April 2019
7 Reads

Treatment of gynecomastia with prednisone: case report and literature review.

J Int Med Res 2019 May 8;47(5):2288-2295. Epub 2019 Apr 8.

contributed equally to this work.

This study aimed to report a unique case of primary adrenal insufficiency that was accompanied by painful gynecomastia, which was resolved by treatment with prednisone. Enlargement of the left breast with continuous weakness and generalized nausea in a male was discovered 3 months before admission. Magnetic resonance imaging of the brain was normal 1 month before presentation. Read More

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http://dx.doi.org/10.1177/0300060519840896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567756PMC
May 2019
27 Reads

Should We Assess Pituitary Function in Children After a Mild Traumatic Brain Injury? A Prospective Study.

Front Endocrinol (Lausanne) 2019 19;10:149. Epub 2019 Mar 19.

Department of Pediatrics, University Medical Center, Amiens, France.

The aim of this study was to evaluate the frequency of hypopituitarism following TBI in a cohort of children who had been hospitalized for mild TBI and to identify the predictive factors for this deficiency. A prospective study was conducted on children between 2 and 16 years of age who had been hospitalized for mild TBI according to the Glasgow Coma Scale between September 2009 and June 2013. Clinical parameters, basal pituitary hormone assessment at 0, 6, and 12 months, as well as a dynamic testing (insulin tolerance test) 12 months after TBI were performed. Read More

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http://dx.doi.org/10.3389/fendo.2019.00149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433821PMC
March 2019
7 Reads

Fluoride Exposure Induces Inhibition of Sodium/Iodide Symporter (NIS) Contributing to Impaired Iodine Absorption and Iodine Deficiency: Molecular Mechanisms of Inhibition and Implications for Public Health.

Int J Environ Res Public Health 2019 03 26;16(6). Epub 2019 Mar 26.

EnviroManagement Services, 11 Riverview, Doherty's Rd, Bandon, Co. Cork, P72 YF10, Ireland.

The sodium iodide symporter (NIS) is the plasma membrane glycoprotein that mediates active iodide transport in the thyroid and other tissues, such as the salivary, gastric mucosa, rectal mucosa, bronchial mucosa, placenta and mammary glands. In the thyroid, NIS mediates the uptake and accumulation of iodine and its activity is crucial for the development of the central nervous system and disease prevention. Since the discovery of NIS in 1996, research has further shown that NIS functionality and iodine transport is dependent on the activity of the sodium potassium activated adenosine 5'-triphosphatase pump (Na+, K+-ATPase). Read More

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http://dx.doi.org/10.3390/ijerph16061086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466022PMC
March 2019
12 Reads