Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations.
Adipocyte 2017 Mar 21:1-7. Epub 2017 Mar 21.
a Department of Internal Medicine , Southern Illinois University School of Medicine , Springfield , Illinois , USA.
A major focus of biogerontology is elucidating the role(s) of the endocrine system in aging and the accumulation of age-related diseases. Endocrine control of mammalian longevity was first reported in Ames dwarf (Prop1(df)) mice, which are long-lived due to a recessive Prop1 loss-of-function mutation resulting in deficiency of growth hormone (GH), thyroid-stimulating hormone, and prolactin. Following this report, several other GH-related mutants with altered longevity have been described including long-lived Snell dwarf and growth hormone receptor knockout mice, and short-lived GH overexpressing transgenic mice. Read More