226,085 results match your criteria Progress in retinal and eye research[Journal]


Let's 'cut to the chase' on malaria elimination in the Greater Mekong Subregion.

Authors:
Sean E Hewitt

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

VBDC Consulting Ltd., Fronteifi House, Cardigan, United Kingdom.

The Greater Mekong Subregion has made remarkable progress towards eliminating malaria in recent years, but efforts are now faltering in some areas. The development of tools to control forest-based transmission is taking too long and efforts to control malaria among high-risk mobile people are failing. If countries are to meet their elimination targets and prevent the spread of multidrug-resistant falciparum malaria, urgent and radical changes will be required. Read More

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December 2018

The Drying Kinetics of Salt Solution Droplets: Water Evaporation Rates and Crystallisation.

J Phys Chem B 2018 Dec 14. Epub 2018 Dec 14.

The drying and crystallisation of solution droplets is a problem of broad relevance, determining the micro-structures of particles formed in spray drying, the phase of particles delivered by, for example, aerosol formulations for inhalation therapies, and the impact of aerosols on radiative forcing and climate. The ephemeral nature of free-droplets, particularly when considering the drying kinetics of droplets with highly volatile constituents, has often precluded the accurate measurement of transient properties such as droplet size and composition, preventing the robust assessment of predictive models of droplet drying rates, nucleation and crystallisation. Here, we report novel measurements of the drying kinetics of individual aqueous sodium chloride solution droplets using a comparative-kinetics electrodynamic balance to isolate and trap single aerosol droplets (radius ~ 25 µm). Read More

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December 2018

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 Dec 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

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December 2018

Economic impact of dengue in Mexico considering reported cases for 2012 to 2016.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.

Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.

Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More

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December 2018

Determining diet from faeces: Selection of metabarcoding primers for the insectivore Pyrenean desman (Galemys pyrenaicus).

PLoS One 2018 14;13(12):e0208986. Epub 2018 Dec 14.

Department of Zoology and Animal Cell Biology, University of the Basque Country UPV/EHU, Leioa, Basque Country, Spain.

Molecular techniques allow non-invasive dietary studies from faeces, providing an invaluable tool to unveil ecological requirements of endangered or elusive species. They contribute to progress on important issues such as genomics, population genetics, dietary studies or reproductive analyses, essential knowledge for conservation biology. Nevertheless, these techniques require general methods to be tailored to the specific research objectives, as well as to substrate- and species-specific constraints. Read More

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December 2018
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The More You Know: Identifying Factors Associated With Inpatient Mortality Related to Opioid Overdose Can Drive Progress in the Opioid Health Crisis.

Anesth Analg 2019 Jan;128(1):16-18

Department of Anesthesiology, University of Michigan School of Medicine, Ann Arbor, Michigan.

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January 2019

The relationship between second language acquisition and nonverbal cognitive abilities.

J Exp Psychol Gen 2018 Dec 13. Epub 2018 Dec 13.

Department of Experimental Psychology.

We monitored the progress of 40 children when they first started to acquire a second language (L2) implicitly through immersion. Employing a longitudinal design, we tested them before they had any notions of an L2 (Time 0) and after 1 school year of L2 exposure (Time 1) to determine whether cognitive abilities can predict the success of L2 learning. Task administration included measures of intelligence, cognitive control, and language skills. Read More

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December 2018

Lean in messages increase attributions of women's responsibility for gender inequality.

J Pers Soc Psychol 2018 Dec;115(6):974-1001

Fuqua School of Business, Duke University.

Although women's underrepresentation in senior-level positions in the workplace has multiple causes, women's self-improvement or "empowerment" at work has recently attracted cultural attention as a solution. For example, the bestselling book states that women can tackle gender inequality themselves by overcoming the "internal barriers" (e.g. Read More

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December 2018

[Progress in the study of artemisinin and its derivatives against head and neck cancer].

Authors:
Y Z Liang X L Nong

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1519-1523

The head and neck cancer is one of the most common malignant tumors in the world. There are more than 600 000 new cases in the world every year. Cisplatin is often used in the treatment of head and neck cancer at present. Read More

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October 2018
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[Research progress of biologics in the treatment of chronic rhinosinusitis].

Authors:
Y Liu F Yuan

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1515-1518

Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal airways and paranasal sinuses. The condition is defined by more than 12 weeks of nasal obstruction, nasal discharge, facial pain/pressure, and reduced/lost smell. CRS is commonly further classified into 2 subsets based on its clinical phenotype: those with polyps (CRSwNP) and those without (CRSsNP). Read More

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October 2018

[Application progress of CO₂ in the treatment of laryngology diseases].

Authors:
W B Lei Y Xu J Deng Y Li

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1447-1450

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October 2018
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[Advances in the treatment of tinnitus].

Authors:
D Wu Y Zheng T Xiang

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1436-1440

Tinnitus is the perception of sound without an external source. Its impact is wide-ranging and heterogeneous across individuals. Since tinnitus is a subjective sensation, the treatment of tinnitus is still in the research and exploration stage at present. Read More

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September 2018

[Research progress on auditory neuropathy spectrum disorder and cochlear implantation in infants and young children].

Authors:
J Y Chen Y X Li

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1120-1124

Auditory neuropathy is a disorder characterized by absent or severely abnormal auditory brainstem response (ABR) with intact outer hair cell function, as evidenced by the presence of evoked otoacoustic emissions and/or cochlear microphonics. Unlike patients with sensory hearing loss who show clinical evidence of impaired outer hair cell function. For ANSD patients, clinical rehabilitation is mainly limited to hearing aid wearing and cochlear implantation. Read More

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[The progress of clinical research on the causes and treatments of pediatric laryngotracheal stenosis].

Authors:
J H Lin Z F Xia

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1114-1119

Pediatric laryngotracheal stenosis is a refractory disease in the present otorhinolaryngological head and neck surgery, including congenital stenosis caused by laryngotracheal deformities and acquired stenosis. The incidence of congenital laryngotracheal malformation has a rising trend.But acquired stenosis is still more common,which is mostly caused by iatrogenic injury (e. Read More

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[Laws regulating transplantation should express the contemporaneity. Questions to the constitutionalist Francesco Paolo Casavola and to the philosophers Remo Bodei and Aldo Masullo about the possibility deciding the destiny of one's own organs at the time one decides on how to die and on contacts between donor families and recipients.]

G Ital Nefrol 2018 Dec;35(6)

Dipartimento di Scienze Mediche Traslazionali, Università della Campania Luigi Vanvitelli, Napoli.

Transplantation represents modernity thus the laws regulating the procedure should be continuously renovated and remodeled in order to take full advantage of progress. The debate is about Law no. 219, December 22, 2017 and on Law no. Read More

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December 2018

Thiol-Disulfide Homeostasis in Cerebral Venous Sinus Thrombosis.

Clin Lab 2018 Oct;64(11)

Background: The objective of this study is to examine thiol-disulfide homeostasis in patients with cerebral venous sinus thrombosis.

Methods: Fifty-three patients diagnosed with cerebral venous sinus thrombosis and 80 healthy volunteers were included in the study. The native thiol and total thiol concentrations were measured with the newly developed automated method. Read More

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October 2018

A New Methodology for Before-After Safety Assessment Using Survival Analysis and Longitudinal Data.

Risk Anal 2018 Dec 14. Epub 2018 Dec 14.

Department of Civil and Urban Engineering, Connected Cities for Smart Mobility towards Accessible and Resilient Transportation (C2SMART) Center, and Center for Urban Science and Progress (CUSP), New York University, Brooklyn, NY, USA.

The widely used empirical Bayes (EB) and full Bayes (FB) methods for before-after safety assessment are sometimes limited because of the extensive data needs from additional reference sites. To address this issue, this study proposes a novel before-after safety evaluation methodology based on survival analysis and longitudinal data as an alternative to the EB/FB method. A Bayesian survival analysis (SARE) model with a random effect term to address the unobserved heterogeneity across sites is developed. Read More

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December 2018

Poly(β-Amino Esters): Synthesis, Formulations, and Their Biomedical Applications.

Adv Healthc Mater 2018 Dec 14:e1801359. Epub 2018 Dec 14.

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Poly(β-amino ester) (abbreviated as PBAE or PAE) refers to a polymer synthesized from an acrylate and an amine by Michael addition and has properties inherent to tertiary amines and esters, such as pH responsiveness and biodegradability. The versatility of building blocks provides a library of polymers with miscellaneous physicochemical and mechanical properties. When used alone or together with other materials, PBAEs can be fabricated into different formulations in order to fulfill various requirements in drug delivery (for instance, gene, anticancer drugs, and antimicrobials delivery) and natural complex mimicry (nanochaperones). Read More

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December 2018
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30 Years After: CNS Actions of Prolactin: Source, Mechanism and Physiological Significance.

J Neuroendocrinol 2018 Dec 14:e12669. Epub 2018 Dec 14.

Centre for Neuroendocrinology and Department of Anatomy, University, Of Otago Medical School,, Dunedin, New Zealand.

Our understanding of the neural actions of prolactin (PRL) and its biochemical basis has expanded greatly over the past three decades. During this time, major progress has been made that includes the elucidation of how PRL accesses the brain, identification of the PRL receptor and the sites where it is expressed within the brain, determination of the neurochemical mechanism of action of PRL and its effect on genomic expression in neurons, identification of the neural sites where PRL acts to stimulate maternal behavior and related affective states, and exploration of how life experiences impact neural PRL receptor activity and actions. The next 30 years promise to reveal a myriad of basic and clinical findings regarding new roles for PRL and a greater in depth understanding of how and where PRL affects physiological and behavioral processes. Read More

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December 2018

Underaddressed animal-welfare issues in conservation.

Conserv Biol 2018 Dec 14. Epub 2018 Dec 14.

College of Veterinary Medicine, School of Veter…cut the number of references to the best 3inary and Life Sciences, Murdoch University, 90 South St, Murdoch, WA 6160, Australia.

Much progress has been made improving animal welfare in conservation over the past two decades. However, several glaring knowledge gaps remain where animal welfare concerns exist but animal welfare studies have not been performed in politically sensitive contexts. We use examples from Australia to identify four such issues lacking meaningful analysis; the absence of animal welfare oversight for operations designated as "management" (as opposed to research), the lack of consideration for the animal welfare impacts of biological agents that are used to control invasive animals, the paucity of studies to examine the welfare of animals that are hunted recreationally, and the scarcity of studies to examine the animal welfare impacts associated with Indigenous wildlife use. Read More

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December 2018

Fused Aromatic Network Structures as a Platform for Efficient Electrocatalysis.

Adv Mater 2018 Dec 14:e1805062. Epub 2018 Dec 14.

School of Energy and Chemical Engineering, Center for Dimension-Controllable Organic Frameworks, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST, Ulsan, 44919, South Korea.

Fused aromatic network (FAN) structures are a category of ordered porous polymers that permit the specific fusion of building blocks into extended porous network structures with designed skeletons and pores. One significant feature of FANs is that their structures can be tailorable with fused aromatic rings without rotatable single-bond connectivity. As a result, the geometry and space orientation of the building blocks are easily incorporated to guide the topological expansion of the architectural periodicity. Read More

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December 2018
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Fruitful first experience with an 8K ultra-high-definition endoscope for laparoscopic colorectal surgery.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Gastrointestinal Surgery, St. Luke's International Hospital, Tokyo, Japan.

We performed laparoscopic surgery for three cases of colorectal cancer using an 8K ultra-high-definition endoscopic system, which offers 16-fold higher resolution than the current 2K high-definition endoscope. The weight of the camera has been successfully reduced to 370 g. To maximize the advantages of the 8K ultra-high-definition endoscope, surgery was performed by darkening the room and placing a large 85-in. Read More

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December 2018

Graphene Oxide as an Optical Biosensing Platform: A Progress Report.

Adv Mater 2018 Dec 14:e1805043. Epub 2018 Dec 14.

Nanobioelectronics and Biosensors Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST, Campus UAB, Bellaterra, 08193, Barcelona, Spain.

A few years ago, crucial graphene oxide (GO) features such as the carbon/oxygen ratio, number of layers, and lateral size were scarcely investigated and, thus, their impact on the overall optical biosensing performance was almost unknown. Nowadays valuable insights about these features are well documented in the literature, whereas others remain controversial. Moreover, most of the biosensing systems based on GO were amenable to operating as colloidal suspensions. Read More

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December 2018

Genome-Wide Maps of Transcription Regulatory Elements and Transcription Enhancers in Development and Disease.

Compr Physiol 2018 Dec 13;9(1):439-455. Epub 2018 Dec 13.

Blood Research Institute, BloodCenter of Wisconsin, a part of Versiti, Milwaukee, Wisconsin, USA.

Gene expression is regulated by numerous elements including enhancers, insulators, transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional start site, called enhancers, play a central role in the temporal and tissue-specific regulation of gene expression through RNA polymerase II. The identification of enhancers and other cis regulatory elements has largely been possible due to advances in next generation sequencing technologies. Read More

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December 2018
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A New Era of Cardiac Cell Therapy: Opportunities and Challenges.

Adv Healthc Mater 2018 Dec 13:e1801011. Epub 2018 Dec 13.

Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC, 27607, USA.

Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the most common causes of death in the United States. Over the last few decades, scientists have invested considerable resources on the study and development of cell therapies for myocardial regeneration after MI. However, due to a number of limitations, they are not yet readily available for clinical applications. Read More

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December 2018

Salt stress under the scalpel - Dissecting the genetics of salt tolerance.

Plant J 2018 Dec 12. Epub 2018 Dec 12.

King Abdullah University of Science and Technology (KAUST), Division of Biological and Environmental Sciences and Engineering, Thuwal, 23955-6900, Kingdom of Saudi Arabia.

Salt stress limits the productivity of crops grown under saline conditions, leading to substantial yield losses in saline soils and under brackish and saline irrigation. Salt tolerant crops could alleviate these losses while both increasing irrigation opportunities and reducing agricultural demands on dwindling freshwater resources. However, despite significant efforts, progress towards this goal has been limited, largely because of genetic complexity of salt tolerance for agronomically important yield-related traits. Read More

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December 2018

The Semiconductor/Conductor Interface Piezoresistive Effect in an Organic Transistor for Highly Sensitive Pressure Sensors.

Adv Mater 2018 Dec 13:e1805630. Epub 2018 Dec 13.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Sciences, Tianjin University, Tianjin, 300072, China.

The piezoresistive pressure sensor, a kind of widely investigated artificial device to transfer force stimuli to electrical signals, generally consists of one or more kinds of conducting materials. Here, a highly sensitive pressure sensor based on the semiconductor/conductor interface piezoresistive effect is successfully demonstrated by using organic transistor geometry. Because of the efficient combination of the piezoresistive effect and field-effect modulation in a single sensor, this pressure sensor shows excellent performance, such as high sensitivity (514 kPa ), low limit of detection, short response and recovery time, and robust stability. Read More

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December 2018

A comparison of the EU regulatory approach to directed mutagenesis with that of other jurisdictions, consequences for international trade and potential steps forward.

New Phytol 2018 Dec 13. Epub 2018 Dec 13.

Biotechnology Directorate, Ministry of AgroIndustry, Buenos Aires, Argentina; National University of Quilmes, Bernal, Argentina.

A special regulatory regime applies to products of recombinant nucleic acid modifications. A ruling from the European Court of Justice has interpreted this regulatory regime in a way that it also applies to emerging mutagenesis techniques. Elsewhere regulatory progress is also ongoing. Read More

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December 2018

Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV.

Methods: Embase, PubMed, and Web of Science were searched for relevant studies. Read More

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December 2018

Converging phenomics and genomics to study natural variation in plant photosynthesis efficiency.

Plant J 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Genetics.

In recent years, developments in plant phenomic approaches and facilities have gradually caught up with genomic approaches. An opportunity lies ahead to dissect complex, quantitative traits when both genotype and phenotype can be assessed at a high level of detail. This is especially true for studying natural variation in photosynthesis efficiency, for which forward genetics studies have yielded only little progress in our understanding of the genetic layout of the trait. Read More

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December 2018

Alkenylboronates: synthesis and applications.

Chem Asian J 2018 Dec 12. Epub 2018 Dec 12.

SPAIN.

Organoboron compounds have become one of the most versatile building blocks in organic synthesis due to their accesible and efficient conversion into many different functional groups. In particular, alkenylboronates have received much attention as very reactive substrates in Suzuki-Miyaura cross-coupling reactions. Accordingly, efforts towards the development of efficient methods to prepare this type of compounds are constant. Read More

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December 2018

Research Progress on Flavor Compounds and Microorganisms of Maotai Flavor Baijiu.

J Food Sci 2018 Dec 12. Epub 2018 Dec 12.

Sichuan Univ. of Science Engineering, No. 180, Xueyuan Street, Huixing road, Zigong City, Sichuan Province, 643000, China.

Maotai-flavor liquor is one of the three basic traditional Chinese baijiu and is also the most famous baijiu in the world. Guizhou Maotai baijiu is the representative of Maotai-flavor liquor, which has a long history of culture and is prepared using unique brewing methods. However, the main flavor of Maotai-flavor liquor as well as the mechanism by which its aroma is produced is unclear. Read More

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December 2018

Draf IIB with superior septectomy: finding the "middle ground".

Int Forum Allergy Rhinol 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, KS.

Background: Previous studies have demonstrated a high failure rate of endoscopic sinus surgery (ESS) with Draf IIa in patients with diffuse polyposis, asthma, and aspirin-exacerbated respiratory disease. A high percentage of these patients progress to endoscopic modified Lothrop procedure (EMLP). We describe a modification of the Draf IIb with a superior septectomy (IIb+SS), which may provide similar therapeutic benefit as demonstrated by the distribution of sinus irrigations in the sinus cavity with ESS with IIb+SS vs ESS with EMLP IIb+SS vs ESS with EMLP. Read More

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December 2018

Structure and function of Rnt1p: An alternative to RNAi for targeted RNA degradation.

Wiley Interdiscip Rev RNA 2018 Dec 11:e1521. Epub 2018 Dec 11.

Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland.

The double-stranded RNA-binding protein (dsRBP) family controls RNA editing, stability, and function in all eukaryotes. The central feature of this family is the recognition of a generic RNA duplex using highly conserved double-stranded RNA-binding domain (dsRBD) that recognizes the characteristic distance between the minor grooves created by the RNA helix. Variations on this theme that confer species and functional specificities have been reported but most dsRBPs retain their capacity to bind generic dsRNA. Read More

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December 2018

Early development of the Australia & New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network.

Intern Med J 2018 Dec 11. Epub 2018 Dec 11.

Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia.

The Australia and New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network was formed to build capacity and infrastructure for high quality musculoskeletal clinical trials in our region. The purpose of this paper is to describe the steps taken in its formation to help others interested in establishing similar networks. In particular we describe the steps taken to form the collaboration and our progress in achieving our vision and mission. Read More

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December 2018

Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Chronic hepatitis (CH) in dogs is common and has the tendency to progress to liver cirrhosis (LC). Circulating microRNAs might have the potential as markers for disease progression.

Objectives: To investigate whether concentration of specific microRNAs in serum correlate with the stage and grade of CH in Labrador Retrievers. Read More

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December 2018
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Bedaquiline and delamanid in the treatment of multidrug-resistant tuberculosis: Promising but challenging.

Drug Dev Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Hit, Lead & Candidate Discovery Improving treatment outcomes in multidrug-resistant tuberculosis (MDR-TB) is partly hampered by inadequate effective antitubercular agents. Development of bedaquiline and delamanid has potentially changed the treatment landscape for MDR-TB. This review provides an update on the progress of these novel antitubercular agents. Read More

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December 2018
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Similar time courses for word form and meaning preactivation during sentence comprehension.

Psychophysiology 2018 Dec 11:e13312. Epub 2018 Dec 11.

Department of Cognitive Science, University of California, San Diego (UCSD), La Jolla, California.

Current psycholinguistic research generally acknowledges that aspects of sentence comprehension benefit from neural preactivation of different types of information. However, despite strong support from a number of studies, routine specific word form preactivation has been challenged by Ito, Corley, Pickering, Martin, and Nieuwland (2016). They suggest that word form prediction is contingent upon having enough processing time and resources (afforded by slower input rates) to progress through unidirectional, productionlike stages of comprehension to arrive at word forms via semantic feature preactivation. Read More

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December 2018

Random Forest Model with Combined Features: A Practical Approach to Predict Liquid-Crystalline Property.

Mol Inform 2018 Dec 7. Epub 2018 Dec 7.

Department of Chemical System Engineering, The University ofTokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

Quantitative structure-property relationships were developed to predict the liquid crystalline (LC) of a large dataset of aromatic organic compounds using machine learning algorithms and different molecular descriptors. The aim of this study was to find appropriate models and descriptors for the prediction of a large variety of liquid crystalline behaviors. Furthermore, descriptor calculations based on LC structural templates were proposed to understand the structural effects on the LC behaviors. Read More

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December 2018

MiRNAs-181a/b therapy in lung cancer: reality or myth?

Mol Oncol 2018 Dec 8. Epub 2018 Dec 8.

Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Despite substantial progress in oncology, lung cancer remains the number one malignancy in terms of both incidence and mortality rates, and there thus remains an urgent need for new therapeutic alternatives. MicroRNAs (miRNAs) have an important role in cancer initiation and progression due to their capacity to interfere with transcriptional signaling and regulate key cellular processes. miR-181a and miR-181b (miR-181a/b), which are located on chromosomes 1 and 9, are pathologically expressed in the tumor tissue and plasma of patients diagnosed with lung cancer. Read More

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December 2018

Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice.

FEBS J 2018 Dec 7. Epub 2018 Dec 7.

Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.

Previous studies have demonstrated that activation of calcineurin induces pathological cardiac hypertrophy. In these studies, loss-of-function was mostly achieved by systemic administration of the calcineurin inhibitor cyclosporin A. The lack of conditional knockout models for calcineurin function has impeded progress toward defining the role of this protein during the onset and the development of cardiac hypertrophy in adults. Read More

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December 2018

Growth-Rule-Guided Structural Exploration of Thiolate-Protected Gold Nanoclusters.

Acc Chem Res 2018 Dec 14. Epub 2018 Dec 14.

College of Chemistry, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education , Xiangtan University , Xiangtan , Hunan 411105 , China.

Understanding the structure and structure-property relationship of atomic and ligated clusters is one of the central research tasks in the field of cluster research. In chemistry, empirical rules such as the polyhedral skeleton electron pair theory (PSEPT) approach had been outlined to account for skeleton structures of many main-group atomic and ligand-protected transition metal clusters. Nonetheless, because of the diversity of cluster structures and compositions, no uniform structural and electronic rule is available for various cluster compounds. Read More

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December 2018

Toward the Cure of HIV-1 Infection: Lessons Learned and Yet to be Learned as New Strategies are Developed.

AIDS Rev 2018 ;20(4):220-225

Department of Neuroscience, Center for Translational AIDS Research, Philadelphia, USA.

Here, we review the progress that has been made in achieving a cure of HIV-1 infection. To date, this has only occurred in one person after he received allogeneic stem cell transplants from a CCR5 ∆32 homozygous donor in addition to chemotherapy and radiation to treat his acute myelocytic leukemia. The general consensus is that achieving a sustained remission of infection in the absence of antiretroviral therapy will involve a combination of strategies that involve both the targeting of the latent proviral genome and the induction of more effective anti-HIV-1 immune responses. Read More

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January 2018

The development of a survey instrument to measure the barriers to the conduct and application of research in complementary and alternative medicine: a Delphi study.

BMC Complement Altern Med 2018 Dec 14;18(1):335. Epub 2018 Dec 14.

Department of Rural Health, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia.

Background: As Complementary and Alternative medicine (CAM) grows in popularity, there is overt recognition for research evidence to inform clinical practice. While various strategies have been trialed to overcome the barriers to such progress, it is important to first understand the extent to which these barriers impact the conduct and application of CAM research. This study aimed to garner consensus and agreement among CAM researchers and practitioners in refining and validating a preliminary survey instrument for measuring these barriers. Read More

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December 2018

Traditional Approaches for Company Valuation Are Flawed for Valuing In Vivo Gene Therapy Companies.

Hum Gene Ther Clin Dev 2018 Dec 14. Epub 2018 Dec 14.

Equity Research Department, Chardan, New York, New York.

The era of gene therapy has begun. In recent years, potentially breakthrough datasets and rapidly expanding company pipelines have begun to overshadow the unfulfilled promise characteristic of the gene therapy sector in decades prior. One barometer for progress in the space can be seen in stock markets, where NASDAQ-listed in vivo gene therapy companies we follow have increased from 4 companies with $1. Read More

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December 2018

Kinetics of Ligand-Protein Dissociation from All-Atom Simulations: Are We There Yet?

Biochemistry 2018 Dec 14. Epub 2018 Dec 14.

Large parallel gains in the development of both computational resources as well as sampling methods have now made it possible to simulate dissociation events in ligand-protein complexes with all--atom resolution. Such encouraging progress, together with the inherent spatiotemporal resolution associated with molecular simulations, has left their use for investigating dissociation processes brimming with potential, both in rational drug design, where it can be an invaluable tool for determining the mechanistic driving forces behind dissociation rate constants, as well as in force-field development, where it can provide a catalog of transient molecular structures on which to refine force-fields. Although much progress has been made in making force-fields more accurate, reducing their error for transient structures along a transition path could yet prove to be a critical development helping to make kinetic predictions much more accurate. Read More

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December 2018

Cardiac cephalgia: A headache of the heart.

J Cardiol Cases 2015 May 27;11(5):139-141. Epub 2015 Feb 27.

Department of Cardiology, Dhaka Medical College, Dhaka, Bangladesh.

Atypical presentations of common diseases are often difficult to identify in time, nonetheless necessary, especially in cases of diseases like ischemic heart disease (IHD) which otherwise may progress into irreversible stage and ultimately, fatality, in the absence of timely administered medical treatment. We report a case of a 51-year-old male, presenting initially with only headache as the sole symptom, who later was diagnosed with severe coronary artery disease, and the symptoms resolved completely after coronary angioplasty with stenting. < Atypical presentations, such as headache, can be more prevalent in ischemic heart disease (IHD) than was thought of, so awareness of the possibility of IHD while assessing headache and further study to see actually how commonly headache is associated with IHD are necessary. Read More

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The Emerging Environmental and Public Health Problem of Electronic Waste in India.

J Health Pollut 2017 Sep 7;7(15):1-7. Epub 2017 Sep 7.

Department of Chemistry, Manav Rachna University, Sector 43, Faridabad, India.

Background: Monumental progress has been made in the area of information and communication technology, leading to a tremendous increase in use of electronic equipment, especially computers and mobile phones. The expansion of production and consumption of electronic equipment along with its shorter life span has led to the generation of tremendous amounts of electronic waste (e-waste). In addition, there is a high level of trans-boundary movement of these devices as second-hand electronic equipment from developed countries, in the name of bridging the digital gap. Read More

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September 2017

Failure of steroid withdrawal guided by F-FDG PET in a patient with cardiac sarcoidosis.

J Cardiol Cases 2017 Jan 15;15(1):10-13. Epub 2016 Nov 15.

Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.

A 71-year-old man diagnosed with cardiac sarcoidosis (CS) 11 years previously underwent implantation of an implantable cardioverter defibrillator due to sustained ventricular tachycardia. Over past decade, his condition of CS did not progress on the maintenance steroid dose of 7.5 mg per day. Read More

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January 2017

Gene Regulatory Network Inference: An Introductory Survey.

Methods Mol Biol 2019 ;1883:1-23

School of Informatics, University of Edinburgh, Edinburgh, UK.

Gene regulatory networks are powerful abstractions of biological systems. Since the advent of high-throughput measurement technologies in biology in the late 1990s, reconstructing the structure of such networks has been a central computational problem in systems biology. While the problem is certainly not solved in its entirety, considerable progress has been made in the last two decades, with mature tools now available. Read More

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January 2019