225,910 results match your criteria Progress in nuclear magnetic resonance spectroscopy[Journal]


Comparison of level of cognitive process between case-based items and non-case-based items of the interuniversity progress test of medicine in the Netherlands.

J Educ Eval Health Prof 2018 12;15:28. Epub 2018 Dec 12.

Department of Cardiology, Catharina Hospital, and Department of Educational Development and Research, and Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands.

Purpose: It is assumed that case-based questions require higher order cognitive processing, whereas questions that are not case-based require lower order cognitive processing. In this study, we investigated to what extent case-based questions and questions that are not case-based, relate to Bloom's taxonomy.

Methods: In this article, 4800 questions of the Progress Test were classified whether it was a case-based question and the level of Bloom's taxonomy. Read More

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December 2018
4 Reads

Health Information Exchange in Emergency Medical Services.

Appl Clin Inform 2018 Oct 12;9(4):884-891. Epub 2018 Dec 12.

The Warren Alpert Medical School, Brown University, Providence, Rhode Island, United States.

Background:  The Office of the National Coordinator for Health Information Technology has outlined the benefits of health information exchange in emergency medical services (EMSs) according to the model-, , , -developed in collaboration with the California Emergency Medical Services Authority.

Objective:  This scoping review aims to identify and characterize progress toward the adoption of prehospital health information exchange, as reported in the peer-reviewed literature.

Methods:  A structured review of literature in MEDLINE-indexed journals was conducted using the "Electronic Health Records" topic-specific query, the "Emergency Medical Services" Medical Subject Headings descriptor, and a prehospital identifier. Read More

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October 2018
1 Read

Xenotransplantation: Progress Along Paths Uncertain from Models to Application.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Translational Medicine and The Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

For more than a century, transplantation of tissues and organs from animals into man, xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest in xenotransplantation was fueled especially by successful application of allotransplantation, that is, transplantation of human tissue and organs, as a treatment for a variety of diseases, especially organ failure because scarcity of human tissues limited allotransplantation to a fraction of those who could benefit. In principle, use of animals such as pigs as a source of transplants would allow transplantation to exert a vastly greater impact than allotransplantation on medicine and public health. Read More

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December 2018
2 Reads

Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

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December 2018
1 Read

A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome.

Cell Rep 2018 Dec;25(11):3215-3228.e9

Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA; School of Biomedical Sciences and Engineering, The University of Maine, Orono, ME 04469, USA; Tufts University School of Medicine, 145 Harrison Avenue, Boston, MA 02111, USA. Electronic address:

Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous white adipose tissue and convert energy stored in metabolic substrates to heat, making them an attractive therapeutic target. We developed a robust method to generate a renewable source of human beige adipocytes from induced pluripotent stem cells (iPSCs). Read More

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December 2018
1 Read

Biomarkers of rejection in kidney transplantation.

Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.

Division of Nephrology, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA.

Purpose Of Review: To provide an update of the literature on the use of new biomarkers of rejection in kidney transplant recipients.

Recent Findings: The kidney allograft biopsy is currently considered the gold standard for the diagnosis of rejection. However, the kidney biopsy is invasive and could be indeterminate. Read More

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December 2018

The Match: To Thine Own Self Be True.

Authors:
Charles G Prober

Acad Med 2018 Dec 11. Epub 2018 Dec 11.

C.G. Prober is professor of pediatrics and of microbiology and immunology, and senior associate vice provost, Health Education, Stanford University, Stanford, California.

The residency match process, culminating with the Match Day celebration, plays out in medical schools across the United States and Canada every year. The process may seem strange and mysterious for observers outside of medicine. The notion that each graduating student's employer for the next several years is first revealed to thousands of people, all at the same moment, through the opening of an envelope is surreal. Read More

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December 2018
1 Read

[Operative treatment of acute mesenteric ischaemia].

Magy Seb 2018 Dec;71(4):149-154

Általános, Ér- és Plasztikai Sebészeti Osztály, Markusovszky Egyetemi Oktatókórház 9700 Szombathely, Markusovszky Lajos u. 5.

Introduction: The incidence of acute mesenteric ischemia (AMI) appears to be increasing due to aging in the population with increasing prevalence of comorbidities. Despite the wide-scale availability of diagnostic technologies, the timely detection and correct treatment are not ensured. This is due to the fact that the required CT angiography is not immediately performed and that vascular surgical reconstruction can be performed within the short ischemic tolerance window of the bowels amounting 4-6 hours. Read More

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December 2018

[Liver bud transplantation in rats].

Magy Seb 2018 Dec;71(4):163-169

Department of Organ Fabrication, Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Introduction: Research has made progress in organ fabrication using an extracellular matrix, cell sheets, or organoids. Human liver tissue has been constructed using a 3-dimensional (3D) bioprinter and showed evidence that an in vitro generated liver bud was reformed in a rodent liver model. This study describes the stages of development of rat fetal organs and liver structure and reviews recent progress in liver organoid transplantation. Read More

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December 2018

Chemistry of Shape-Controlled Iron Oxide Nanocrystal Formation.

ACS Nano 2018 Dec 12. Epub 2018 Dec 12.

Herein we demonstrate that meticulous and in-depth analysis of the reaction mechanisms of nanoparticle formation is rewarded by full control of size, shape and crystal structure of superparamagnetic iron oxide nanocrystals during synthesis. Starting from two iron sources - iron(II)- and iron(III) carbonate -a strict separation of oleate formation from the generation of reactive pyrolysis products and concomitant nucleation of iron oxide nanoparticles was achieved. This protocol enabled us to analyze each step of nanoparticle formation independently in depth. Read More

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December 2018

Refluxed Esterification of Fullerenes Conjugated P25 TiO2 Promotes Free Radical Scavenging Capacity and Facilitates Anti-aging Potentials in Human Cells.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Titanium dioxide nanomaterials have good capability to prevent human cells from damage under UV irradiation. However, some studies indicated that the nanoscale of titanium dioxide could potentially cause harmful effects such as free radicals generation under UV irradiation and thereby accelerate the progress of cell aging. Fullerenes can scavenge large amounts of free radicals due to the fact that fullerenes contain enormous amount of π electrons with low lying lowest unoccupied molecular orbital (LUMO), but its adverse properties, such as the poor solubility in water, restricted the applicability. Read More

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December 2018

Suction Stability Management in SMILE: Development of a Decision Tree for Managing Eye Movements and Suction Loss.

J Refract Surg 2018 Dec;34(12):809-816

Purpose: To develop a comprehensive protocol for suction stability management during small incision lenticule extraction (SMILE).

Methods: This was a retrospective video review of all SMILE cases where suction loss occurred or eye movement was noted in the medical record. The different types of eye movement were collated. Read More

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December 2018

Phys-MAPS: a programmatic physiology assessment for introductory and advanced undergraduates.

Adv Physiol Educ 2019 Mar;43(1):15-27

Molecular, Cellular, and Developmental Biology, University of Colorado-Boulder , Boulder, Colorado.

We describe the development of a new, freely available, online, programmatic-level assessment tool, Measuring Achievement and Progress in Science in Physiology, or Phys-MAPS ( http://cperl.lassp.cornell. Read More

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[Evaluation of 114 abnormal Pap smear follow-up in ambulatory care.]

Sante Publique 2018 July August;30(4):527-532

Aim: In France, cervical cancer screening has led to a decrease in mortality, though it could be optimized by improving the management of abnormal cytology. The aim was to evaluate the follow-up of women with abnormal Pap smear prescribed by an ambulatory health professional, compared to the ANAES guidelines of 2002.

Method: Quantitative monocentric and retrospective study of 120 women with abnormal Pap smear performed before October 2014 in the French department of the Loire. Read More

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December 2018

Education-service integration in the context of Brazilian medical schools: an integrative review.

Cien Saude Colet 2018 Dec;23(12):4241-4248

Escola Paulista de Medicina, Universidade Federal de São Paulo. Santos SP Brasil.

This paper aimed to characterize the historical trajectory, including the advances and challenges, of the teaching-service integration in the medical training process. In this context, through scientific studies indexed in databases, a critical review of the literature was performed from the search for works of reference until the present moment. Most of the works consulted were reference material on the topic published in scientific journals and indexed in the databases of the Virtual Health Library. Read More

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December 2018

Sodium content and food additives in major brands of Brazilian children's foods.

Cien Saude Colet 2018 Dec;23(12):4065-4075

Instituto Federal de Educação, Ciência e Tecnologia de Goiás. Av.Universitária Vereador Vagner da Silva Qd 01, Lt 1-A Parque Itatiaia, 74968-755 Aparecida de Goiânia GO Brasil.

The objective of this paper is to evaluate the sodium content and additive usage in packaged food products targeted at Brazilian children. Commercial database and manufactures' websites were used to identify major brands of child-oriented foods. Samples were categorized as "children's foods" (n = 214) and "infant's foods" (n = 86). Read More

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December 2018
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Moving from maternal death review to surveillance and response: A paradigm shift.

Indian J Public Health 2018 Oct-Dec;62(4):299-301

Junior Resident, Department of Community Medicine, Maulana Azad Medical College, New Delhi, India.

In the era of the sustainable development goals, India is committed to reduce its maternal mortality ratio to less than 70 per one lakh live births by 2030. An important strategy that was adopted in the Reproductive and Child Health Programme in 2010 was maternal death review. Analysis of the progress so far has brought to light certain gaps which have prompted the paradigm shift toward Maternal Death Surveillance and Response (MDSR), which focuses on taking action on information obtained from every maternal death so as to prevent further maternal deaths. Read More

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December 2018

imaging of structural, metabolic and functional brain changes in glaucoma.

Neural Regen Res 2019 Mar;14(3):446-449

NYU Langone Eye Center, Department of Ophthalmology, NYU School of Medicine, NYU Langone Health; Department of Radiology, NYU School of Medicine, NYU Langone Health; Center for Neural Science, Faculty of Arts and Science, New York University, New York, NY, USA.

Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. Read More

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March 2019
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Liquid-Biopsy-Based Identification of EGFR T790M Mutation-Mediated Resistance to Afatinib Treatment in Patients with Advanced EGFR Mutation-Positive NSCLC, and Subsequent Response to Osimertinib.

Target Oncol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.

Background: Acquired epidermal growth factor receptor (EGFR) T790M mutation is the primary resistance mechanism to first-generation EGFR tyrosine kinase inhibitors (TKIs) used in advanced, EGFR mutation-positive non-small-cell lung cancer (NSCLC). Available data, predominantly in Asian patients, suggest that this mutation is also the major cause of resistance to the irreversible ErbB family blocker, afatinib. For EGFR T790M-positive patients who progress on EGFR TKI therapy, osimertinib is an effective treatment option. Read More

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December 2018

Epitope Mapping via Phage Display from Single-Gene Libraries.

Methods Mol Biol 2019 ;1904:353-375

Abteilung Biotechnologie, Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig, Germany.

Antibodies are widely used in a large variety of research applications, for diagnostics and therapy of numerous diseases, primarily cancer and autoimmune diseases. Antibodies are binding specifically to target structures (antigens). The antigen-binding properties are not only dependent on the antibody sequence, but also on the discrete antigen region recognized by the antibody (epitope). Read More

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January 2019

Minority Participation in Biobanks: An Essential Key to Progress.

Methods Mol Biol 2019 ;1897:43-50

Translating Research Across Communities (TRAC), Green Cove Springs, FL, USA.

Biobanks are critical resources for biomedical research and will be a driving force behind personalized medicine. Although biobanking efforts are increasing across the USA and the world, minority populations are frequently underrepresented in biobanks, which undermines their value. A number of factors have been linked to low rates of minority participation in biobanks, including mistrust of researchers, concerns about privacy and confidentiality, logistical barriers to participation, and inadequate opportunities to participate. Read More

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January 2019

Preparation of ion exchange resin using soluble starch and acrylamide by graft polymerization and hydrolysis.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

College of Chemistry and Chemical Engineering, Southwest Petroleum University, No. 8 Xindu District, Chengdu, 610500, People's Republic of China.

Based on soluble starch and acrylamide by performing graft polymerization in aqueous solution and hydrolysis step, a low-cost ion exchange resin has been synthesized to remove the heavy metal ions of Cr and Ni. The hydrolysis progresses by adding NaOH to convert -CONH to -COONa, and the adsorption experiments confirmed that the functional group to adsorb heavy metals is -COO, rather than -CONH. During the determination of heavy metal adsorption, the Na concentration diffused by SR-16 into the solution was also analysed to investigate the ion exchange process. Read More

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December 2018

Significant inter- and intra-laboratory variation in grading of ductal carcinoma in situ of the breast: a nationwide study of 4901 patients in the Netherlands.

Breast Cancer Res Treat 2018 Dec 11. Epub 2018 Dec 11.

Foundation PALGA (the nationwide network and registry of histo-and cytopathology in the Netherlands), Houten, The Netherlands.

Purpose: A considerable part of ductal carcinoma in situ (DCIS) lesions may never progress into invasive breast cancer. However, standard treatment consists of surgical excision. Trials aim to identify a subgroup of low-risk DCIS patients that can safely forgo surgical treatment based on histologic grade, which highlights the importance of accurate grading. Read More

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December 2018
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MiR-101-3p inhibits EMT to attenuate proliferation and metastasis in glioblastoma by targeting TRIM44.

J Neurooncol 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Kaifu District, Changsha, 410008, Hunan, People's Republic of China.

Background: Glioblastoma (GBM) is the most common malignant tumor originating in the brain parenchyma. The invasive and infiltrative properties of glioblastoma result in poor clinical prognosis to conventional therapies. Emerging reports on microRNAs as important regulators during the process of EMT provide new insights into treating glioblastoma through new targets. Read More

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December 2018

A comparison of crown preparation grading via PrepCheck versus grading by dental school instructors.

Int J Comput Dent 2018 ;21(4):305-311

Recent reports in the literature demonstrate the influence that digital dentistry is having on the preclinical training of dental students. However, none of these articles have discussed the use of PrepCheck (Sirona Dental Systems) in the evaluation of preparation taper in a preclinical environment. The present study compared the subjective grading of student tooth preparations by experienced, well-calibrated faculty with objective digital grading of the same preparations by means of the PrepCheck software. Read More

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January 2018

Molecular evolution and genomics of hepatitis B virus subgenotype C2 strain predominant in the chronic patients in Bangladesh.

Virusdisease 2018 Dec 17;29(4):486-490. Epub 2018 Oct 17.

Molecular Biotechnology Division, National Institute of Biotechnology, Savar, Dhaka, 1349 Bangladesh.

Evolution of hepatitis B virus (HBV) is a mystery and caused mainly by genomic mutations as well as recombination. Viral evolution may be responsible for increasing disease severity and render resistance to the existing treatment processes. HBV/C2 strain is associated with chronicity, which may progress to the liver cirrhosis and hepatocellular carcinoma. Read More

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December 2018

Tuberculosis elimination in Oman: winning the war on the disease.

ERJ Open Res 2018 Oct 7;4(4). Epub 2018 Dec 7.

Office of Health Affairs, Ministry of Health, Muscat, Oman.

In 2014, the World Health Assembly adopted the new End TB Strategy that targets ending tuberculosis (TB) by 2035. This article describes the progress made to eliminate TB in Oman. Data from officials and other sources provided the information to assess the situation in Oman. Read More

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October 2018

"Feelings and Fitness" Not "Feelings or Fitness"-The of Conservation Welfare, Which Aligns Conservation and Animal Welfare Objectives.

Front Vet Sci 2018 27;5:296. Epub 2018 Nov 27.

Royal New Zealand Society for the Prevention of Cruelty to Animals, Auckland, New Zealand.

Increasingly, human activities, including those aimed at conserving species and ecosystems (conservation activities) influence not only the survival and fitness but also the welfare of wild animals. Animal welfare relates to how an animal is experiencing its life and encompasses both its physical and mental states. While conservation biology and animal welfare science are both multi-disciplinary fields that use scientific methods to address concerns about animals, their focus and objectives sometimes appear to conflict. Read More

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November 2018

Gene Therapy for Cystic Fibrosis Lung Disease: Overcoming the Barriers to Translation to the Clinic.

Front Pharmacol 2018 27;9:1381. Epub 2018 Nov 27.

Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.

Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease caused by mutations in the CF Transmembrane-Conductance Regulator () gene. Unrelenting airway disease begins in infancy and produces a steady deterioration in quality of life, ultimately leading to premature death. While life expectancy has improved, current treatments for CF are neither preventive nor curative. Read More

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November 2018

Multifaceted remediation program: experience of a residency program to rescue residents who failed the American Board of Anesthesiology basic examination.

Adv Med Educ Pract 2018 26;9:865-871. Epub 2018 Nov 26.

Department of Anesthesiology and Perioperative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA,

Problem: Passing the American Board of Anesthesiology (ABA) basic examination is required to progress through anesthesiology training in USA. Failing the test may be related to medical knowledge gaps, presence of negative psychosocial factors, and/or individual approaches to learning. This article describes the experience of development and implementation of a multifaceted remediation program (MRP) in residents who failed the ABA basic test. Read More

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November 2018

Cytoskeleton-associated protein 4 is a novel serodiagnostic marker for esophageal squamous-cell carcinoma.

Onco Targets Ther 2018 20;11:8221-8226. Epub 2018 Nov 20.

Department of Oncology, Suqian People's Hospital, Nanjing Drum Tower Hospital Group, Suqian, China,

Background: Recent years have witnessed significant progress in the treatment of esophageal squamous-cell carcinoma (ESCC); however, the prognosis of ESCC is still unsatisfactory. Bio-markers are required to improve identification of high-risk populations and help management of ESCC. This study was to evaluate the role of serum CKAP4 in ESCC. Read More

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November 2018

Diagnosis and control of chicken coccidiosis: a recent update.

J Parasit Dis 2018 Dec 29;42(4):483-493. Epub 2018 Oct 29.

Discipline of Genetics, School of Life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Westville, P/Bag X54001, Durban, 4000 South Africa.

Coccidiosis is a deadly disease that hampers chicken's productivity and welfare. Thus, the disease is a major menace to the global poultry industry. Coccidiosis which is caused by the apicomplexan parasite of the genus has seven known species which affect the different parts of the intestinal tract of chickens. Read More

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December 2018
1 Read

Prebiotic plausibility and networks of paradox-resolving independent models.

Authors:
Steven A Benner

Nat Commun 2018 12 12;9(1):5173. Epub 2018 Dec 12.

Foundation for Applied Molecular Evolution, Westheimer Institute for Science and Technology, 13709 Progress Blvd., Alachua, FL, 32615, USA.

The plausibility of any model in science comes from the extent of its interconnections to other models that are grounded in different premises and reasoning. Focusing research on paradoxes in those models, logic whereby they appear to generate unacceptable conclusions from seemingly indisputable premises, helps find those interconnections. Read More

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December 2018

A quarter of a century of SERF: The progress of an NMR pulse sequence and its application.

Authors:
Stefan Berger

Prog Nucl Magn Reson Spectrosc 2018 Oct 28;108:74-114. Epub 2018 Nov 28.

Institute of Analytical Chemistry, University Leipzig, Johannisallee 29, D-04103 Leipzig, Germany. Electronic address:

SERF, an NMR pulse sequence for selectively measuring a spin coupling constant without interference from other couplings, was published by the current author almost 25 years ago in 1995. Since then, about 35 modifications and extensions of the original have been published by other groups and applied to many chemical problems. This review discusses these modifications and provides pertinent examples. Read More

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October 2018

The impact of a hyaluronic acid-grafted layer on the surface properties of model silicone hydrogel contact lenses.

Langmuir 2018 Dec 12. Epub 2018 Dec 12.

The introduction of high oxygen transmissibility silicone hydrogel lenses ameliorated hypoxia-related complications, making them the most prescribed type of contact lens. Despite the progress made over the last two decades to improve their clinical performance, symptoms of ocular dryness and discomfort and a variety of adverse clinical events are still reported. Consequently, the rate of contact lens wear discontinuation has not been appreciably diminished by their introduction. Read More

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December 2018

Pulmonary hypertension in a patient with intravascular lymphomatosis.

J Cardiol Cases 2013 Jun 18;7(6):e181-e183. Epub 2013 Mar 18.

Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Oomiya-ku, Saitama 330-8503, Japan.

Intravascular lymphomatosis (IVL) is a rare subtype of lymphoma characterized by proliferation of lymphoma cells into small vessels. Clinical presentations of IVL are considerably varied among patients, and antemortem diagnosis is sometimes difficult. We report a 75-year-old Japanese female who presented with gradually worsening shortness of breath and pulmonary hypertension. Read More

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June 2013
1 Read

Successful implanted pacemaker for an extreme inhibitory reflex syncope evoked by post herpetic trigeminal neuralgia.

J Cardiol Cases 2013 Jun 25;7(6):e173-e175. Epub 2013 Mar 25.

Department of Cardiology, Veterans Affairs Medical Center, Dayton, OH, USA.

Syncope is defined as a transient loss of consciousness due to cerebral hypoperfusion characterized by rapid onset, short duration, and spontaneous complete recovery. Numerous causes of syncope have been described. Vasovagal syncope is the most common with a number of precipitants. Read More

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Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection.

Cell Physiol Biochem 2018 11;51(5):2377-2396. Epub 2018 Dec 11.

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou,

The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. Read More

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December 2018

Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells.

Biofabrication 2018 Dec 11. Epub 2018 Dec 11.

Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing, CHINA.

Growth-hormone-secreting pituitary adenoma (GHSPA) is a benign tumour with a high incidence and large economic burden, which greatly affects quality of life. The aetiological factors are yet to be clarified for GHSPA. Conventional two-dimensional (2D) monolayer culture of tumour cells cannot ideally reflect the growth status of tumours in the physiological environment, and insufficiencies of in vitro models have severely restricted the progress of cancer research. Read More

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December 2018

Recent advances in engineering Corynebacterium glutamicum for utilization of hemicellulosic biomass.

Curr Opin Biotechnol 2018 Dec 8;57:17-24. Epub 2018 Dec 8.

Department of Chemical and Biomolecular Engineering (BK Plus program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; Institute for the BioCentury, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea. Electronic address:

Corynebacterium glutamicum has been mainly used for industrial production of amino acids, and in recent years, it has also been successfully engineered to broaden its range of substrate and product profiles. In particular, C. glutamicum has been engineered to use non-natural sugar substrates (mainly pentoses) derived from hemicellulosic feedstock, which is the second abundant component of lignocellulosic biomass. Read More

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December 2018
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Three-gene immunohistochemical panel predicts progression and unfavorable prognosis in esophageal squamous cell carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi 832002, China. Electronic address:

Esophageal squamous cell carcinoma (ESCC) is a highly invasive disease with a poor long-term survival rate. Although there has been progress in understanding the pathogenesis of ESCC, there are currently no molecular biomarkers that are used in routine clinical practices to determine prognosis. Therefore, the aim of this study was to determine a small immunohistochemical (IHC) panel that could predict the prognosis of patients with ESCC. Read More

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December 2018
2.769 Impact Factor

Measuring Value in Post-Acute Care.

Arch Phys Med Rehabil 2018 Dec 8. Epub 2018 Dec 8.

John F. Butzer Center for Research and Innovation, Mary Free Bed Rehabilitation Hospital, Grand Rapids, MI; Division of Rehabilitation, Michigan State University College of Human Medicine, Grand Rapids, MI.

The value of post-acute care is unclear. While experienced clinicians understand the appropriateness of each specific site of post-acute care, clear evidence-based guidelines are not available, and many referrals to post-acute care today are made based on bed availability rather than patient need. Measuring value (value = outcomes / cost) for the entire episode of care has been proposed as an effective method to both evaluate and enable faster innovation in care. Read More

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December 2018

Regression in Children with Epilepsy.

Neurosci Biobehav Rev 2018 Dec 8. Epub 2018 Dec 8.

Department of Pediatrics, Dalhousie University and the IWK Health Centre, Canada.

Regression in children with epilepsy may involve loss of cognitive abilities, failure to progress or a slowing of developmental trajectory. A few seizures do not lead to regression. Large numbers of seizures may be associated with regression but the cause is an important cofounder. Read More

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December 2018

A NEW COMPREHENSIVE PROCEDURE FOR CUSTOM-MADE TOTAL ANKLE REPLACEMENTS: MEDICAL IMAGING, JOINT MODELING, PROSTHESIS DESIGN, AND 3D PRINTING.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

Movement Analysis Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Many failures in total joint replacement are associated to prosthesis-to-bone mismatch. With recent additive-manufacturing, i.e. Read More

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December 2018

Bibliometric analysis of scientific publications in respiratory journals from China and other top-ranking countries between 2007 and 2017.

Clin Respir J 2018 Dec 10. Epub 2018 Dec 10.

Department of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.

Introduction: Respiratory disease remains one of the leading causes of mortality and morbidity worldwide.

Objectives: In this study, we aimed to compare the quantity and quality of scientific publications in the field of respirology from the USA, the UK, Germany, Canada and China.

Methods: Articles published in 58 respiratory journals from 2007 to 2017 were screened with Science Citation Index Expanded database. Read More

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December 2018

The current trends of Mg alloys in biomedical applications-A review.

J Biomed Mater Res B Appl Biomater 2018 Dec 7. Epub 2018 Dec 7.

School of Engineering and Technology, Central Michigan University, Mount Pleasant, Michigan, 48859.

Magnesium (Mg) has emerged as an ideal alternative to the permanent implant materials owing to its enhanced properties such as biodegradation, better mechanical strengths than polymeric biodegradable materials and biocompatibility. It has been under investigation as an implant material both in cardiovascular and orthopedic applications. The use of Mg as an implant material reduces the risk of long-term incompatible interaction of implant with tissues and eliminates the second surgical procedure to remove the implant, thus minimizes the complications. Read More

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December 2018

Identification of prognostic miRNA biomarkers for predicting overall survival of colon adenocarcinoma and bioinformatics analysis: A study based on The Cancer Genome Atlas database.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Pharmacy, First Affiliated Hospatial of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Object: This study was conducted to identify the prognostic microRNA (miRNA) for the prediction of survival in colon adenocarcinoma (CA).

Methods: miRNA profiling of patients with CA was downloaded from The Cancer Genome Atlas (TCGA) database. After data processing, univariate Cox regression was performed to select potential prognostic miRNAs. Read More

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December 2018
1 Read