231,858 results match your criteria Progress in community health partnerships : research education and action[Journal]


Artificial Intelligence in Medicine: Weighing the Accomplishments, Hype, and Promise.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Biomedical Informatics, Columbia University.

Introduction: Artificial Intelligence in Medicine (AIM) research is now 50 years old, having made great progress that has tracked the corresponding evolution of computer science, hardware technology, communications, and biomedicine. Characterized as being in its "adolescence" at an international meeting in 1991, and as "coming of age" at another meeting in 2007, the AIM field is now more visible and influential than ever before, paralleling the enthusiasm and accomplishments of artificial intelligence (AI) more generally.

Objectives: This article summarizes some of that AIM history, providing an update on the status of the field as it enters its second half-century. Read More

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http://dx.doi.org/10.1055/s-0039-1677891DOI Listing

Characterising GPCR-ligand interactions using a fragment molecular orbital-based approach.

Curr Opin Struct Biol 2019 Apr 22;55:85-92. Epub 2019 Apr 22.

Institute of Structural & Molecular Biology, Research Department of Structural & Molecular Biology, Division of Biosciences, University College London, London,WC1E 6BT, United Kingdom.

There has been fantastic progress in solving GPCR crystal structures. However, the ability of X-ray crystallography to guide the drug discovery process for GPCR targets is limited by the availability of accurate tools to explore receptor-ligand interactions. Visual inspection and molecular mechanics approaches cannot explain the full complexity of molecular interactions. Read More

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http://dx.doi.org/10.1016/j.sbi.2019.03.021DOI Listing

Revisiting metabolic engineering strategies for microbial synthesis of oleochemicals.

Metab Eng 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, United States; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Wisconsin-Madison, Madison, WI 53706, United States; Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address:

Microbial production of oleochemicals from renewable feedstocks remains an attractive route to produce high-energy density, liquid transportation fuels and high-value chemical products. Metabolic engineering strategies have been applied to demonstrate production of a wide range of oleochemicals, including free fatty acids, fatty alcohols, esters, olefins, alkanes, ketones, and polyesters in both bacteria and yeast. The majority of these demonstrations synthesized products containing long-chain fatty acids. Read More

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http://dx.doi.org/10.1016/j.ymben.2019.04.009DOI Listing

Natural products in Licorice for the therapy of liver diseases: Progress and future opportunities.

Pharmacol Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Microbiology and Immunology, Virginia Commonwealth University, 1217 E Marshall St. KMSB, Richmond, VA 23298, USA; School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Beisanhuandonglu road, Beijing 100029, China. Electronic address:

Liver diseases related complications represent a significant source of morbidity and mortality worldwide, creating a substantial economic burden. Oxidative stress, excessive inflammation, and dysregulated energy metabolism significantly contributed to liver diseases. Therefore, discovery of novel therapeutic drugs for the treatment of liver diseases are urgently required. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.025DOI Listing

L-cysteine and poly-L-arginine grafted carboxymethyl cellulose/Ag-In-S quantum dot fluorescent nanohybrids for in vitro bioimaging of brain cancer cells.

Int J Biol Macromol 2019 Apr 22. Epub 2019 Apr 22.

Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais - UFMG, Av. Antônio Carlos, 6627 Belo Horizonte, MG, Brazil. Electronic address:

Although noticeable scientific and technological progress, cancer remains one of the deadliest diseases worldwide and advancements in diagnosis, targeting and treating cancer cells are an urgency. In this study, we designed and synthesized novel amino acid and polypeptide modified polysaccharide derivatives associated with fluorescent nanomaterials for producing nanohybrids with functionalities for bioimaging and cell penetrating. Carboxymethylcellulose (CMCel) was chemically biofunctionalized with L-cysteine (CMCelCys) or poly-L-arginine (CMCelPolyArg) and the conjugates were used as capping ligands for synthesizing fluorescent AgInS quantum dots (AIS-QDs) in aqueous colloidal media. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.140DOI Listing

More than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea.

Am J Respir Crit Care Med 2019 Apr 25. Epub 2019 Apr 25.

University of California, San Diego, Division of Pulmonary and Critical Care Medicine, San Diego, California, United States.

Traditionally, the presence and severity of obstructive sleep apnea (OSA) has been defined by the apnea-hypopnea index (AHI). Continuous positive airway pressure (CPAP) is generally first line therapy despite low adherence as it reliably reduces the AHI when used, and the response to other therapies is variable. However, there is growing appreciation that the underlying etiologies (i. Read More

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http://dx.doi.org/10.1164/rccm.201901-0014TRDOI Listing

Maternal healthcare insurance ownership and service utilisation in Ghana: Analysis of Ghana Demographic and Health Survey.

PLoS One 2019 25;14(4):e0214841. Epub 2019 Apr 25.

Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.

Objectives: Previous studies have attempted to assess the role of health insurance on health care utilization in African settings. However, there is limited evidence on the effects of health insurance on use of maternal health care. In the present study our objective was to measure the prevalence of insurance ownership, types of services covered by the insurance and the association of insurance ownership with the utilization of respective maternal health services in Ghana. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214841PLOS

Continued Disparities in Postpartum Follow-Up and Screening Among Women With Gestational Diabetes and Hypertensive Disorders of Pregnancy: A Systematic Review.

J Perinat Neonatal Nurs 2019 Apr/Jun;33(2):136-148

College of Nursing and Health Sciences, University of Massachusetts Boston (Dr Jones); Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado School of Medicine, Aurora (Dr Hernandez); College of Nursing, University of Colorado, Anschutz Medical Campus, Aurora (Dr Hernandez); Connell School of Nursing, Boston College, Boston, Massachusetts (Dr Edmonds); and Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia (Dr Ferranti).

The postpartum period represents a critical window to initiate targeted interventions to improve cardiometabolic health following pregnancies complicated by gestational diabetes mellitus and/or a hypertensive disorder of pregnancy. The purpose of this systematic review was to examine studies published since 2011 that report rates of postpartum follow-up and risk screening for women who had gestational diabetes and/or a hypertensive disorder of pregnancy and to identify disparities in care. Nine observational studies in which postpartum follow-up visits and/or screening rates were measured among US women following pregnancies complicated by gestational diabetes and/or a hypertensive disorder of pregnancy were reviewed. Read More

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http://dx.doi.org/10.1097/JPN.0000000000000399DOI Listing

Latent Representation Learning for Alzheimer's Disease Diagnosis with Incomplete Multi-modality Neuroimaging and Genetic Data - Supplementary Materials.

IEEE Trans Med Imaging 2019 Apr 25. Epub 2019 Apr 25.

The fusion of complementary information contained in multi-modality data (e.g., Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET) and genetic data) has advanced the progress of automated Alzheimer's disease (AD) diagnosis. Read More

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http://dx.doi.org/10.1109/TMI.2019.2913158DOI Listing
April 2019
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How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for De Novo siRNA Guide Strand Surrogate Selection.

J Chem Inf Model 2019 Apr 25. Epub 2019 Apr 25.

The Argonaute-2 protein is part of the RNA-induced silencing complex (RISC) and anchors the guide strand of the small interfering RNA (siRNA). The 3' end of the RNA contains two unpaired nucleotides (3'-overhang) that interact with the PAZ (PIWI-Argonaute-Zwille) domain of the protein. Theoretical and experimental evidence points towards a direct connection between the PAZ/3'-overhang binding affinity and siRNA's potency and specificity. Read More

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http://dx.doi.org/10.1021/acs.jcim.8b00892DOI Listing

Quantifying reaction and rate heterogeneity in battery electrodes in 3D through operando X-ray diffraction computed tomography.

ACS Appl Mater Interfaces 2019 Apr 25. Epub 2019 Apr 25.

In composite battery electrode architectures, local limitations in ionic and electronic transport can result in non-uniform energy storage reactions. Understanding such reaction heterogeneity is important to optimizing battery performance including rate capability and mitigating degradation and failure. Here, we use spatially-resolved X-ray diffraction computed tomography to map the reaction in a composite electrode based on LiFePO active material as it undergoes charge and discharge. Read More

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http://dx.doi.org/10.1021/acsami.9b02173DOI Listing

Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma: New insight into skin epithelial homeostasis and avenues for treatment.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Pachyonychia congenita (PC), a rare genodermatosis, primarily affects ectoderm-derived epithelial appendages and typically includes oral leukokeratosis, nail dystrophy, and very painful palmoplantar keratoderma (PPK). PC dramatically impacts quality of life though it does not affect lifespan. PC can arise from mutations in any of the wound repair-associated keratin genes KRT6A, KRT6B, KRT6C, KRT16, or KRT17. Read More

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http://dx.doi.org/10.1111/bjd.18033DOI Listing

Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer.

JAMA Oncol 2019 Apr 25. Epub 2019 Apr 25.

Institute of Immunobiology, Kantonsspital St Gallen, St Gallen, Switzerland.

Importance: Immunotherapy with checkpoint inhibitors targeting the PD-1 (programmed cell death 1) axis has brought notable progress in patients with non-small cell lung cancer (NSCLC) and other cancers. However, autoimmune toxic effects are frequent and poorly understood, making it important to understand the pathophysiologic processes of autoimmune adverse effects induced by checkpoint inhibitor therapy.

Objective: To gain mechanistic insight into autoimmune skin toxic effects induced by anti-PD-1 treatment in patients with non-small cell lung cancer. Read More

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2019.0402DOI Listing
April 2019
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Comparative genomics and metagenomics of the metallomes.

Metallomics 2019 Apr 25. Epub 2019 Apr 25.

Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong Province, P. R. China.

Biological trace metals are needed by all living organisms in very small quantities. They play important roles in a variety of key cellular processes, resulting in a varying degree of dependence on metals for different organisms. While most effort has been placed on identifying metal metabolic pathways and characterizing metalloproteins and their functions, computational and systematical analyses of the metallomes (or metalloproteomes) have been limited. Read More

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http://dx.doi.org/10.1039/c9mt00023bDOI Listing

Adapting State-of-the-Art Deep Language Models to Clinical Information Extraction Systems: Potentials, Challenges, and Solutions.

JMIR Med Inform 2019 Apr 25;7(2):e11499. Epub 2019 Apr 25.

Research School of Computer Science, College of Engineering and Computer Science, The Australian National University, Canberra, Australia.

Background: Deep learning (DL) has been widely used to solve problems with success in speech recognition, visual object recognition, and object detection for drug discovery and genomics. Natural language processing has achieved noticeable progress in artificial intelligence. This gives an opportunity to improve on the accuracy and human-computer interaction of clinical informatics. Read More

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http://medinform.jmir.org/2019/2/e11499/
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http://dx.doi.org/10.2196/11499DOI Listing
April 2019
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Classification and Nomenclature of CRISPR-Cas Systems: Where from Here?

CRISPR J 2018 Oct;1:325-336

National Center for Biotechnology Information , National Library of Medicine, Bethesda, Maryland.

As befits an immune mechanism, CRISPR-Cas systems are highly variable with respect to Cas protein sequences, gene composition, and organization of the genomic loci. Optimal classification of CRISPR-Cas systems and rational nomenclature for CRISPR-associated genes are essential for further progress of CRISPR research. These are highly challenging tasks because of the complexity of CRISPR-Cas and their fast evolution, including frequent module shuffling, as well as the lack of universal markers for a consistent evolutionary classification. Read More

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http://dx.doi.org/10.1089/crispr.2018.0033DOI Listing
October 2018

Specific Effects of Individualized Cognitive Training in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): The Role of Pre-Training Cognitive Impairment and Individual Training Performance.

Dev Neurorehabil 2019 Apr 25:1-15. Epub 2019 Apr 25.

a Department of Child and Adolescent Psychiatry and Psychotherapy , University Hospital of Psychiatry, University of Zurich , Zurich , Switzerland.

Objective: We investigated the impact of the pre-training neuropsychological (NP) impairment and of the training progress on the NP and behavioural outcome after computerized cognitive training (CogT) in children with ADHD.

Method: Thirty-one participants underwent individualized CogT (focussing on one or two cognitive domains: working memory, inhibition, attention) over 12 weeks. NP tests and behaviour ratings served as outcome measures. Read More

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http://dx.doi.org/10.1080/17518423.2019.1600064DOI Listing

Engineering CRISPR-Cas9 RNA-Protein Complexes for Improved Function and Delivery.

CRISPR J 2018 Dec;1:367-378

3 Innovative Genomics Institute , University of California , Berkeley, CA 94720.

The use of CRISPR-derived, RNA-guided nucleases for genome editing has shown great promise for addressing genetic disease. Encouraging work in cell culture and animal models has demonstrated the capability of genome-editing enzymes to correct disease-causing loci, but clinical translation can only proceed once the corrective enzymes have been rendered safe, effective, and capable of being delivered to the appropriate cells. To address these needs, there has been rapid and extensive progress in the engineering of the RNA and protein components of Cas9, the most widely-used genome editor. Read More

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http://dx.doi.org/10.1089/crispr.2018.0037DOI Listing
December 2018

Planting Progress: An Interview with Neal Gutterson.

CRISPR J 2018 Aug;1:270-273

Kevin Davies, Executive Editor, The CRISPR Journal, New Rochelle, New York, ; Neal Gutterson, Chief Technology Officer, Corteva Agriscience, Agriculture Division of DowDuPont, Wilmington, Delaware.

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http://dx.doi.org/10.1089/crispr.2018.29023.intDOI Listing

4-Hydroxymethyl-substituted oxazolidinone synthesis by tetraarylphosphonium salt-catalyzed reactions of glycidols with isocyanates.

Chem Commun (Camb) 2019 Apr 25. Epub 2019 Apr 25.

Department of Materials Chemistry, Faculty of Engineering, Shinshu University, 4-17-1 Wakasato, Nagano 380-8553, Japan.

Preparation of 4-hydroxymethyl-substituted oxazolidinones including optically active ones, in which tetraarylphosphonium salts catalyze the reaction of glycidol with isocyanates effectively, is described. The neutral catalysis facilitates glycidol addition to isocyanates followed by intramolecular cyclization. Mechanistic studies suggest that hydrogen-bonding interactions with the catalyst play an important role in the reaction progress. Read More

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http://dx.doi.org/10.1039/c9cc01983aDOI Listing

Emerging biomedical applications of algal polysaccharides.

Curr Pharm Des 2019 Apr 23. Epub 2019 Apr 23.

Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran. Iran.

Background: Over the past two decades, there have been substantial progress and growing body of research on using natural polymeric biomaterials as drug delivery carries which is owing to their exceptional biocompatibility and biodegradability. Among different natural biopolymers, polysaccharides have gained considerable attraction among biomedical scientists and surgeons due to their biocompatibility, biodegradability, anti-inflammatory, and antimicrobial properties. In the recent years, algal-based polysaccharides including agar, alginate, and carrageenan, have been broadly suggested for different biological and biomedical applications. Read More

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http://dx.doi.org/10.2174/1381612825666190423160357DOI Listing

Mechanism for Diffusion through Secondary Cell Walls in Lignocellulosic Biomass.

Authors:
Joseph E Jakes

J Phys Chem B 2019 Apr 25. Epub 2019 Apr 25.

The future bioeconomy depends on increased utilization of renewable lignocellulosic resources from trees and other bioenergy crops. However, considering that the diffusion of ions, chemicals, and enzymes into secondary cell walls is critical to effectively utilize lignocellulosic biomass, the unidentified mechanisms underpinning this diffusion has hindered progress. Here, nanomechanical spectroscopy was used to measure changes in moisture-dependent relaxations of amorphous polysaccharides inside loblolly pine (Pinus taeda) cell wall layers. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b01430DOI Listing

Evaluation of Electron Impact Ionization Cross Sections for Molecules.

J Phys Chem A 2019 Apr 25. Epub 2019 Apr 25.

We describe the recent progress in the development of the semi-empirical approach developed by Jain and Khare for the calculations of ionization cross sections for molecules by electron impact. Along with the state-of-the-art description of this approach, the emphasis will be on the evaluation of cross sections for carbon dimer C2 and trimer C3. Single-differential ionization cross sections as a function of secondary or ejected electron energy and averaged secondary electron energy for C2 and C3 are calculated at fixed impinging electron energies of 100 and 200 eV. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b02021DOI Listing

A Dual Energy Transfers-Based Fluorescent Nanoprobe for Imaging miR-21 in Non-Alcoholic Fatty Liver Cells with Low Background.

Anal Chem 2019 Apr 25. Epub 2019 Apr 25.

Non-alcoholic fatty liver disease (NAFLD) can progress gradually to liver failure, early warning of which is critical for improving the cure rate of NAFLD. In situ imaging and monitoring of overexpressed miR-21 is an advanced strategy for NAFLD diagnosis. However, this strategy usually suffers from the high background imaging in living cells owing to the complexity of the biological system. Read More

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http://pubs.acs.org/doi/10.1021/acs.analchem.9b00841
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http://dx.doi.org/10.1021/acs.analchem.9b00841DOI Listing
April 2019
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AbRSA: A robust tool for antibody numbering.

Protein Sci 2019 Apr 24. Epub 2019 Apr 24.

Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China.

The remarkable progress in cancer immunotherapy in recent years has led to the heat of great development for therapeutic antibodies. Antibody numbering, which standardizes a residue index at each position of an antibody variable domain, is an important step in immunoinformatic analysis. It provides an equivalent index for the comparison of sequences or structures, which is particularly valuable for antibody modeling and engineering. Read More

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http://dx.doi.org/10.1002/pro.3633DOI Listing

Protective effect of ulinastatin on hepatic ischemia reperfusion injury through autophagy activation in Chang liver cells.

J Cell Biochem 2019 Apr 24. Epub 2019 Apr 24.

Sir Run Run Shaw Hospital, Zhe Jiang University School of Medicine, Hangzhou, China.

This study aimed to investigate the protective effect of ulinastatin in hepatic ischemia-reperfusion progress, involving its association with the role of autophagy during hypoxia-induced hypoxia-reoxygenation injury in vitro. The model of hepatic hypoxia/reoxygenation (H/R) injury in Chang liver cells was established. After treatment with ulinastatin at the doses of 10, 100, and 1000 U/mL in H/R liver cells, the cell proliferation was significantly increased, morphological damage was reduced, and the cell apoptosis rate was decreased. Read More

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http://dx.doi.org/10.1002/jcb.28758DOI Listing

The role of autophagy in maintaining intestinal mucosal barrier.

J Cell Physiol 2019 Apr 24. Epub 2019 Apr 24.

Key Laboratory of Molecular Animal Nutrition of the Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, China.

The intestinal mucosal barrier is the first line to defense against luminal content penetration and performs numerous biological functions. The intestinal epithelium contains a huge surface that is lined by a monolayer of intestinal epithelial cells (IECs). IECs are dominant mediators in maintaining intestinal homeostasis that drive diverse functions including nutrient absorption, physical segregation, secretion of antibacterial peptides, and modulation of immune responses. Read More

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http://dx.doi.org/10.1002/jcp.28722DOI Listing

Asymptomatic hyperuricemia and cardiovascular mortality in patients with chronic kidney disease who progress to hemodialysis.

Int Urol Nephrol 2019 Apr 24. Epub 2019 Apr 24.

Department of Nephrology, Clinic for Internal Medicine, University Medical Centre Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia.

Purpose: Hyperuricemia has been associated with higher mortality in the general population, but less is known about CKD patients. The aim of our study was to determine the impact of elevated serum uric acid on cardiovascular mortality of CKD patients who later progress to hemodialysis.

Methods: In this retrospective study, 120 CKD patients (entire population of patients with ESKD on January 1st, 2012) were observed from their first visit at the Nephrology outpatient clinic, while transitioning to hemodialysis, and until their death or January 1, 2016. Read More

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http://dx.doi.org/10.1007/s11255-019-02154-wDOI Listing

Clinical update on hypomethylating agents.

Int J Hematol 2019 Apr 24. Epub 2019 Apr 24.

INSERM/CNRS UMR 944/7212, Saint-Louis Research Institute, Paris Diderot University, Paris, France.

Hypomethylating agents (HMAs), azacitidine and decitabine, are standards of care in higher-risk myelodysplastic syndromes and in acute myeloid leukemia patients ineligible for intensive therapy. Over the last 10 years, research efforts have sought to better understand their mechanism of action, both at the molecular and cellular level. These efforts have yet to robustly identify biomarkers for these agents. Read More

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http://dx.doi.org/10.1007/s12185-019-02651-9DOI Listing

BUSCO: Assessing Genome Assembly and Annotation Completeness.

Methods Mol Biol 2019 ;1962:227-245

Department of Genetic Medicine and Development, Swiss Institute of Bioinformatics, University of Geneva Medical School, Geneva, Switzerland.

Genomics drives the current progress in molecular biology, generating unprecedented volumes of data. The scientific value of these sequences depends on the ability to evaluate their completeness using a biologically meaningful approach. Here, we describe the use of the BUSCO tool suite to assess the completeness of genomes, gene sets, and transcriptomes, using their gene content as a complementary method to common technical metrics. Read More

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http://dx.doi.org/10.1007/978-1-4939-9173-0_14DOI Listing
January 2019

Mechanisms of Severe Cutaneous Adverse Reactions: Recent Advances.

Authors:
Teresa Bellón

Drug Saf 2019 Apr 24. Epub 2019 Apr 24.

La Paz Hospital Health Research Institute-IdiPAZ, Pº Castellana 261, 28046, Madrid, Spain.

Cutaneous adverse drug reactions are unpredictable and include various different skin conditions of varying degrees of severity. The most concerning are usually referred to as severe cutaneous adverse reactions (SCARs) and include acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DiHS) or hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). All are delayed type IV hypersensitivity reactions in which a T-cell-mediated drug-specific immune response is responsible for causing the disease. Read More

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http://dx.doi.org/10.1007/s40264-019-00825-2DOI Listing

Mathematical Modelling and Simulation of Atherosclerosis Formation and Progress: A Review.

Ann Biomed Eng 2019 Apr 24. Epub 2019 Apr 24.

Thermal Hydraulics and Multiphase Flow Laboratory, National Centre for Scientific Research "Demokritos", Athens, Greece.

Cardiovascular disease (CVD) is a major threat to human health since it is the leading cause of death in western countries. Atherosclerosis is a type of CVD related to hypertension, diabetes, high levels of cholesterol, smoking, oxidative stress, and age. Atherosclerosis primarily occurs in medium and large arteries, such as coronary and the carotid artery and, in particular, at bifurcations and curvatures. Read More

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http://dx.doi.org/10.1007/s10439-019-02268-3DOI Listing

A case report: metastatic complete heart block.

Eur Heart J Case Rep 2018 Dec 29;2(4):yty131. Epub 2018 Nov 29.

Department of Cardiology, Seth GS Medical College, KEM Hospital, Achary Dhonde MargParel, Mumbai, Maharashtra, India.

Background: Though primary malignant tumours of the heart are rare, secondary metastatic affection of the heart is quite common. Common presentations include pericardial effusion, obstruction of inflow and outflow tracts and arrhythmias, most notably tachyarrhythmias, and very rarely complete heart blocks (CHBs).

Case Summary: A 28-year-old man suffering from carcinoma of the tongue underwent a surgery in the form of radical hemimandibulectomy. Read More

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https://academic.oup.com/ehjcr/article/doi/10.1093/ehjcr/yty
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http://dx.doi.org/10.1093/ehjcr/yty131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426093PMC
December 2018
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Progressive cardiac involvement in a compound heterozygote Fabry patient: a case report.

Eur Heart J Case Rep 2018 Dec 7;2(4):yty122. Epub 2018 Dec 7.

Cardiology Department, Royal North Shore Hospital, Sydney, Australia.

Background: Fabry disease is an X-linked lysosomal storage disorder due to mutations in the gene encoding for alpha-galactosidase A, with subsequent accumulation of complex sphingolipids in multiple organs, including the heart. Female heterozygotes can develop cardiac involvement although this is usually milder and slower to progress compared with male hemizygotes.

Case Summary: A 71-year-old woman with two separate pathological Fabry mutations (N215S, C202R; compound heterozygote) presented with progressive cardiac involvement despite enzyme replacement therapy (ERT) with Replagal, as demonstrated by troponin elevation and cardiovascular magnetic resonance (CMR) findings: moderate segmental left ventricular dysfunction with wall thinning, low myocardial native T1, and extensive late gadolinium enhancement with co-located increased T2. Read More

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https://academic.oup.com/ehjcr/article/doi/10.1093/ehjcr/yty
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http://dx.doi.org/10.1093/ehjcr/yty122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426117PMC
December 2018
1 Read

Gastrointestinal Conditions in Children With Severe Feeding Difficulties.

Glob Pediatr Health 2019 16;6:2333794X19838536. Epub 2019 Apr 16.

Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL, USA.

Feeding aversion in children may progress to severe feeding difficulties. While oral-motor and sensory issues are usually the leading causes, organic etiologies should be considered. This study aimed to assess the prevalence of gastrointestinal conditions in children with severe feeding difficulties. Read More

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http://dx.doi.org/10.1177/2333794X19838536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469270PMC

Is severe re-expansion pulmonary edema still a lethal complication of closed thoracostomy or thoracic surgery?

Ann Transl Med 2019 Mar;7(5):98

Department of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Gyeongsangnam-do, South Korea.

Background: Re-expansion pulmonary edema (REPE) is a lethal complication that can occur after inserting a chest tube. However, no clinical research reports have analyzed the progress and treatment of REPE, except for a single case report review. We retrospectively analyzed the common clinical characteristics, clinical progress, and treatment outcome of REPE with respiratory failure. Read More

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http://dx.doi.org/10.21037/atm.2019.01.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462659PMC

Intermittent hypoxia enhances the tumor programmed death ligand 1 expression in a mouse model of sleep apnea.

Ann Transl Med 2019 Mar;7(5):97

Department of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen 361004, China.

Background: As a hallmark of obstructive sleep apnea (OSA), intermittent hypoxia (IH) promotes tumor progress. The high expression of programmed death 1 and programmed death ligand 1 (PD-L1) in tumor leads to immune evasion and subsequently aggravates tumor progress. This study aims to determine the tumor PD-L1 expression under the IH condition. Read More

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http://dx.doi.org/10.21037/atm.2019.01.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462651PMC

Association between carotid plaque and Parkinson's disease.

Ann Transl Med 2019 Mar;7(5):94

Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: Epidemiological studies show that patients with Parkinson's disease (PD) are prone to have a reduced incidence of ischemic cerebrovascular disease. Previous studies show the correlation between PD and the lipids serum levels. The PD,s patients are found with a reduced serum level of triglyceride and low-density lipoprotein cholesterol (LDL-C); thus, the level of serum uric acid (UA) is closely related to the occurrence and development of PD. Read More

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http://dx.doi.org/10.21037/atm.2019.01.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462637PMC

Impact of Recent Clinical Trials on Nephrology Practice: Are We in a Stagnant Era?

Kidney Dis (Basel) 2019 Mar 19;5(2):69-80. Epub 2018 Dec 19.

Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, Kentucky, USA.

Background: Although renal replacement therapy prevents death from uremia, survival among patients with acute and chronic kidney diseases (CKD) remains an imperative concern. The expected life span of US dialysis patients 60-64 years of age is approximately 4.5 years; this is similar to that of patients with lung cancer. Read More

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http://dx.doi.org/10.1159/000495139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465696PMC

The context of litigation in evaluating physical and psychological outcomes from pain management programmes.

Br J Pain 2019 May 18;13(2):99-105. Epub 2018 Dec 18.

Pain Management Programme, The Walton Centre NHS Foundation Trust, Liverpool, UK.

Objectives: There has been extensive research in evaluating chronic pain in the context of litigation while considering the implications that it can have on healthcare outcomes and rehabilitation progress. The aim of this article is to present retrospective observational data about the levels of disability and distress reported by patients with ongoing litigation at the start and following a UK-based multi-disciplinary pain management programme (PMP) when compared with those without litigation.

Method: Between June 2014 and September 2017, 859 patients attended and completed a 16-day PMP at a tertiary-level National Health Service (UK) pain clinic. Read More

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http://dx.doi.org/10.1177/2049463718820056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463350PMC

Research Methods and Progress of Patellofemoral Joint Kinematics: A Review.

J Healthc Eng 2019 24;2019:9159267. Epub 2019 Mar 24.

Orthopedics Department, Peking University International Hospital, Life Park 1, Zhongguancun Life Science Park, Changping District, Beijing, China.

Patellofemoral pain syndrome has a high morbidity, and its pathology is closely associated with patellofemoral joint kinematics. A series of and studies have been conducted to explore patellofemoral kinematics, and the findings are relevant to the diagnosis, classification, and management of patellofemoral diseases and even the whole knee joint. However, no definite conclusion on normal patellofemoral kinematics has been established. Read More

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http://dx.doi.org/10.1155/2019/9159267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451817PMC

The Role of 3D Printing in Medical Applications: A State of the Art.

J Healthc Eng 2019 21;2019:5340616. Epub 2019 Mar 21.

BEAMS Department, Université Libre de Bruxelles, Bruxelles 1050, Belgium.

Three-dimensional (3D) printing refers to a number of manufacturing technologies that generate a physical model from digital information. Medical 3D printing was once an ambitious pipe dream. However, time and investment made it real. Read More

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https://www.hindawi.com/journals/jhe/2019/5340616/
Publisher Site
http://dx.doi.org/10.1155/2019/5340616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451800PMC
March 2019
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[Contribution of concomitant radiochemotherapy in the management of undifferentiated carcinoma of the nasopharynx in adults].

Pan Afr Med J 2018 10;31:98. Epub 2018 Oct 10.

Service de Radiothérapie, CHU Hassan II, Faculté de Médecine et de Pharmacie de Fès, Maroc.

This study aimed to investigate the epidemiological, clinical, therapeutic and evolutionary features of undifferentiated carcinoma of the nasopharynx in adults. We conducted a retrospective cohort study of 163 patients aged 17 years old and over, treated for non metastatic undifferentiated carcinoma of the nasopharynx. The average age of our patients was 46,5 years, with a sex-ratio of 1. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.98.14951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465754PMC
October 2018

Use of Health Information Technology among Patient Navigators in Community Health Interventions.

Perspect Health Inf Manag 2019 1;16(Spring):1a. Epub 2019 Apr 1.

RTI International in Research Triangle Park, NC.

Overview: As chronic disease and comorbidities increase, so does the complexity of patient care.This complexity requires interdisciplinary care teams and multifactor interventions to ensure that patients get the most efficient care. Patient navigators-defined as individuals who help patients move through the complex care continuum-can improve access to care and patient engagement, which can translate into better outcomes. Read More

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April 2019
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Technology for Augmenting Type 1 Diabetes Mellitus Management.

J Pediatr Pharmacol Ther 2019 Mar-Apr;24(2):99-106

Type 1 diabetes mellitus has witnessed significant progress in its management over the past several decades. This review highlights technologic advancements in type 1 diabetes management. Continuous glucose monitoring systems are now available at various functionality and cost levels, addressing diverse patient needs, including a recently US Food and Drug Administration (FDA)-approved implantable continuous glucose monitoring system (CGMS). Read More

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http://dx.doi.org/10.5863/1551-6776-24.2.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478356PMC

Searching by grant number: comparison of funding acknowledgments in NIH RePORTER, PubMed, and Web of Science.

Authors:
Kimberly Powell

J Med Libr Assoc 2019 Apr 1;107(2):172-178. Epub 2019 Apr 1.

Research Impact Informationist, Woodruff Health Sciences Center Library, Emory University, Atlanta, GA

Objective: Several publication databases now index the associated funding agency and grant number metadata with their publication records. Librarians who are familiar with the particulars of these databases can assist investigators and administrators with data gathering for publication summaries and metrics required for renewals of and progress reports for National Institutes of Health (NIH) grants.

Methods: Publication lists were pulled from three main indexers of publication-associated funding information (NIH RePORTER, PubMed, and Web of Science), using iterative search strategies. Read More

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http://dx.doi.org/10.5195/jmla.2019.554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466482PMC

Studying fungal pathogens of humans and fungal infections: fungal diversity and diversity of approaches.

Genes Immun 2019 Apr 25. Epub 2019 Apr 25.

Unité Biologie et Pathogénicité Fongiques, Département de Mycologie, Institut Pasteur, USC2019 INRA, Paris, 75015, France.

Seminal work by Louis Pasteur revealed the contribution of fungi-yeasts and microsporidia to agroindustry and disease in animals, respectively. More than 150 years later, the impact of fungi on human health and beyond is an ever-increasing issue, although often underestimated. Recent studies estimate that fungal infections, especially those caused by Candida, Cryptococcus and Aspergillus species, kill more than one million people annually. Read More

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http://dx.doi.org/10.1038/s41435-019-0071-2DOI Listing

Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms.

mSphere 2019 Apr 24;4(2). Epub 2019 Apr 24.

Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil

The thermodimorphic pathogenic fungi and are the etiologic causes of paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America. Galectin-3 (Gal-3), an animal β-galactoside-binding protein, modulates important roles during microbial infections, such as triggering a Th2-polarized immune response in PCM. Herein, we demonstrate that Gal-3 also plays other important roles in infection. Read More

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http://dx.doi.org/10.1128/mSphere.00209-19DOI Listing

External fixation of the lower extremities: Biomechanical perspective and recent innovations.

Injury 2019 Apr 5. Epub 2019 Apr 5.

Institute for Biomechanics, Trauma Centre Murnau, Germany; Institute for Biomechanics, Paracelsus Medical University, Salzburg, Austria.

The concept of supporting fractured long bones externally with mechanical fixation has been evidentially applied for over 2000 years, and since been expanded on in the mid-19th century by percutaneous bone fixation. Surgical techniques, external fixator systems, and materials have made continued progress since. The benefits of traditional external fixation have been enhanced in recent years with the introduction of hexapod-style fixators, innovative configurations, and pin modifications, among other things. Read More

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http://dx.doi.org/10.1016/j.injury.2019.03.041DOI Listing