226,111 results match your criteria Progress in community health partnerships : research education and action[Journal]


Delays in the reading and spelling of children with cerebral palsy: Associations with phonological and visual processes.

Res Dev Disabil 2018 Dec 12;85:131-142. Epub 2018 Dec 12.

Open University, Walton Hall, Milton Keynes MK7 6AA, United Kingdom.

Background: This investigation addresses the question of whether there exists a significant discrepancy in the cognitive abilities of children with cerebral palsy (CP) who, despite the presence of age appropriate communication and language, have reading and spelling delays.

Aims: We wanted to discover whether there was a relationship between the phonological and visual perceptual abilities of children with CP and their progress in reading and spelling.

Methods And Procedures: Fifteen children with CP (aged between 6:9 years and 11:6 years) were assessed on reading and spelling; communication and language; non-verbal reasoning; phonological processing; and visual perception. Read More

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December 2018

A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study.

J Pharm Biomed Anal 2018 Dec 10;165:198-206. Epub 2018 Dec 10.

Bioanalytical Sciences, Bristol-Myers Squibb, Princeton, NJ, 08543, USA.

Stable isotope labeled (SIL) compounds have been commonly used as internal standards (IS) to ensure the accuracy and quality of liquid chromatography-mass spectrometry (LC-MS) bioanalytical assays. Recently, the application of SIL drugs and LC-MS assays to microdose absolute bioavailability (BA) studies has gained increasing attention. This approach can provide significant cost and time saving, and higher data quality compared to the accelerator mass spectrometry (AMS)-based method, since it avoids the use of radioactive drug, high-cost AMS instrumentation and complex measurement processes. Read More

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December 2018
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A decade of Nucleic Acid Programmable Protein Arrays (NAPPA) availability: News, actors, progress, prospects and access.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Proteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain; Department of Medicine and General Cytometry Service-Nucleus, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain. Electronic address:

Understanding the dynamic of the proteome is a critical challenge because it requires high sensitive methodologies in high-throughput formats in order to decipher its modifications and complexity. While molecular biology provides relevant information about cell physiology that may be reflected in post-translational changes, High-Throughput (HT) experimental proteomic techniques are essential to provide valuable functional information of the proteins, peptides and the interconnections between them. Hence, many methodological developments and innovations have been reported during the last decade. Read More

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December 2018

Bundle payment model in spine surgery: Current challenges and opportunities, a systematic review.

World Neurosurg 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, University of Louisville, 200 Abraham Flexner Hwy, Louisville, KY, U.S.A- 40202. Electronic address:

Introduction: Bundled payments offer a lump sum for management of particular conditions over a specified time period that has the potential to reduce healthcare payments. Additionally, bundled payments represent a shift toward patient-centered reimbursement that has the upside of improved care coordination among providers and may lead to improved outcomes.

Aim: To review the challenges and sources of payment variation and opportunities for restructuring bundled payments plans in context of spine surgery. Read More

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December 2018
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Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Background: Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.

Methods: p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.

Results: In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Read More

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December 2018

Developmental origins of murine γδ T cell subsets.

Immunology 2018 Dec 15. Epub 2018 Dec 15.

Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, E1 2AT.

Murine γδ T cells display diverse responses to pathogens and tumours through early provision of pro-inflammatory cytokines such as interleukin-17A (IL-17) and interferon-γ (IFNγ). Although it is now clear that acquisition of these cytokine-secreting effector fates is to a great extent developmentally pre-programmed in the thymus, the stages through which γδ progenitor cells transition, and the underlying mechanistic processes that govern these commitment events, are still largely unclear. Here, we review recent progress in the field, with particular consideration to how TCRγδ signalling impacts on developmental programs initiated prior to TCRγδ expression. Read More

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December 2018

Patients' experiences and perspectives of challenges and needs related to non-myeloablative stem cell transplantation: involving patients in developing a targeted rehabilitation programme.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Public Health, Section for Clinical Social Medicine and Rehabilitation, Faculty of Health, Aarhus University, Denmark.

Aims And Objectives: To explore patients' experiences and perspectives of their challenges and needs regarding their return to everyday life after allogeneic non-myeloablative haematopoietic stem cell transplantation (NMA-HSCT).

Background: NMA-HSCT can cure patients with malignant blood diseases, but during the following years the majority of patients suffer from serious side effects and complications. Hence, it is a major challenge for patients treated with NMA-HSCT to rehabilitate, maintain physical and psychosocial functioning and return to a life in restored balance. Read More

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December 2018
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Scutellarein inhibits RANKL-induced osteoclast formation in vitro and prevents LPS-induced bone loss in vivo.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Osteoporosis, arthritis, Peget's disease, bone tumor, periprosthetic joint infection, and periprosthetic loosening have a common characteristic of osteolysis, which is characterized by the enhanced osteoclastic bone resorptive function. At present, the treatment target of these diseases is to interfere with osteoclastic formation and function. Scutellarein (Scu), a flavonoids compound, can inhibit the progress of tumor and inflammation. Read More

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December 2018

The Drug Shortage Crisis in the United States: Impact on Cancer Pharmaceutical Safety.

Cancer Treat Res 2019 ;171:75-92

University of Colorado Denver, Denver, CO, USA.

Drug shortages pose a significant public health concern in the United States, and cancer drugs are among those most affected. Shortages present serious safety risks for patients and substantial burden on providers and the healthcare system. Multifaceted drivers of this complex problem include manufacturing disruptions, raw material shortages, regulatory issues, market dynamics, and limited financial incentives that reward quality and production of off-patent drugs. Read More

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January 2019

Biosimilars: Are They Really Safe?

Cancer Treat Res 2019 ;171:61-73

Robert H. Lurie Comprehensive Cancer Center Northwestern University, Chicago, IL, USA.

An increasing availability of biosimilars is an important step in the process of delivering optimal care while improving access for patients with cancer. Evolving regulatory mechanisms deal with biosimilars with different approaches within major regulatory agencies. We discuss some of the specific properties of biosimilars that merit attention in terms of optimizing their safety, delivering on appropriate related cost savings, and ensuring that appropriate premiums on innovative research are available to ensure ongoing progress in anticancer therapy. Read More

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January 2019
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Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

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December 2018
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Comparison of three variant callers for human whole genome sequencing.

Sci Rep 2018 Dec 14;8(1):17851. Epub 2018 Dec 14.

Computational Biology Unit, Institute of Informatics, University of Bergen, Bergen, Norway.

Testing of patients with genetics-related disorders is in progress of shifting from single gene assays to gene panel sequencing, whole-exome sequencing (WES) and whole-genome sequencing (WGS). Since WGS is unquestionably becoming a new foundation for molecular analyses, we decided to compare three currently used tools for variant calling of human whole genome sequencing data. We tested DeepVariant, a new TensorFlow machine learning-based variant caller, and compared this tool to GATK 4. Read More

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December 2018

Click chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures.

Nat Commun 2018 Dec 14;9(1):5323. Epub 2018 Dec 14.

Department of Chemistry, Georgetown University, 37th and O Streets, Washington, DC, 20057, USA.

Click reactions have become powerful synthetic tools with unique applications in the health and materials sciences. Despite the progress with optical sensors that exploit the principles of dynamic covalent chemistry, metal coordination or supramolecular assemblies, quantitative analysis of complex mixtures remains challenging. Herein, we report the use of a readily available coumarin conjugate acceptor for chiroptical click chirality sensing of the absolute configuration, concentration and enantiomeric excess of several compound classes. Read More

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December 2018

Focused Resident Education and Engagement in Quality Improvement Enhances Documentation, Shortens Hospital Length of Stay, and Creates a Culture of Continuous Improvement.

J Surg Educ 2018 Dec 12. Epub 2018 Dec 12.

Comprehensive Aortic Center, Cardiovascular Thoracic Institute, Keck Medical Center of University of Southern California, Los Angeles, California. Electronic address:

Purpose: System-based practice with an emphasis on quality improvement (QI) is a recent initiative for the American College of Surgeons and a core-competency for surgical trainees. Few surgical training programs have a curriculum for hospital-based QI.

Methods: Our vascular surgery service implemented several QI initiatives focused on decreasing length of stay (LOS) by targeting resident education and engagement. Read More

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December 2018

Progress, challenges, and the role of public engagement to improve tick-borne disease literacy.

Authors:
Joyce M Sakamoto

Curr Opin Insect Sci 2018 Aug 26;28:81-89. Epub 2018 May 26.

Department of Entomology, The Pennsylvania State University, University Park, PA 16802 United States; Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802 United States. Electronic address:

Vector-borne diseases have increased worldwide, facilitated by globalization and variations in climate. Tick and tick-borne disease researchers, veterinarians, medical practitioners, and public health specialists are working to share their expertise on tick ecology, disease transmission, diagnostics, and treatment in order to control tick-borne epidemics and potential pandemics. This review will be a brief overview of the current status of tick-borne diseases, challenges on the scientific and public fronts, and the role of public engagement in improving citizen education within the context of ticks and tick-borne disease research. Read More

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Glucosinolate Profiling and Expression Analysis of Glucosinolate Biosynthesis Genes Differentiate White Mold Resistant and Susceptible Cabbage Lines.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Department of Horticulture, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam 57922, Korea.

Sclerotinia stem rot (white mold), caused by the fungus , is a serious disease of crops worldwide. Despite considerable progress in investigating plant defense mechanisms against this pathogen, which have revealed the involvement of glucosinolates, the host⁻pathogen interaction between cabbage () and has not been fully explored. Here, we investigated glucosinolate profiles and the expression of glucosinolate biosynthesis genes in white-mold-resistant (R) and -susceptible (S) lines of cabbage after infection with . Read More

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December 2018

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Department of Biochemistry, College of Medicine, Konyang University, 158, Gwanjeodong-ro, Seo-gu, Daejeon 35365, Korea.

Alzheimer's disease (AD) is a neurodegenerative disease, which is accompanied by memory loss and cognitive dysfunction. Although a number of trials to treat AD are in progress, there are no drugs available that inhibit the progression of AD. As the aggregation of amyloid-β (Aβ) peptides in the brain is considered to be the major pathology of AD, inhibition of Aβ aggregation could be an effective strategy for AD treatment. Read More

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December 2018
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Enhancement of the efficacy of mesenchymal stem cells in the treatment of ischemic diseases.

Biomed Pharmacother 2019 Jan 26;109:2022-2034. Epub 2018 Nov 26.

Key Laboratory of Transplant Engineering and Immunology, NHFPC, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, PR China. Electronic address:

Ischemic diseases refer to a wide range of diseases caused by reduced blood flow and a subsequently deficient oxygen and nutrient supply. The pathogenesis of ischemia is multifaceted and primarily involves inflammation, oxidative stress and an apoptotic response. Over the last decade, mesenchymal stem cells (MSCs) have been widely studied as potential cell therapy agents for ischemic diseases due to their multiple favourable functions. Read More

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January 2019

Application of rat cryptorchidism model for the evaluation of mesenchymal stromal cell secretome regenerative potential.

Biomed Pharmacother 2019 Jan 13;109:1428-1436. Epub 2018 Nov 13.

Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russian Federation; Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russian Federation. Electronic address:

Male infertility represents a severe social and medical challenge. In recent years the progress in regenerative medicine promoted the development of novel options to overcome this medical condition. We are elaborating a promising approach to restore spermatogenesis using mesenchymal stromal cell (MSC) secretome components as a novel class of cell-free cell therapy medicinal products for regenerative medicine. Read More

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January 2019

Let's 'cut to the chase' on malaria elimination in the Greater Mekong Subregion.

Authors:
Sean E Hewitt

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

VBDC Consulting Ltd., Fronteifi House, Cardigan, United Kingdom.

The Greater Mekong Subregion has made remarkable progress towards eliminating malaria in recent years, but efforts are now faltering in some areas. The development of tools to control forest-based transmission is taking too long and efforts to control malaria among high-risk mobile people are failing. If countries are to meet their elimination targets and prevent the spread of multidrug-resistant falciparum malaria, urgent and radical changes will be required. Read More

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December 2018

The Drying Kinetics of Salt Solution Droplets: Water Evaporation Rates and Crystallisation.

J Phys Chem B 2018 Dec 14. Epub 2018 Dec 14.

The drying and crystallisation of solution droplets is a problem of broad relevance, determining the micro-structures of particles formed in spray drying, the phase of particles delivered by, for example, aerosol formulations for inhalation therapies, and the impact of aerosols on radiative forcing and climate. The ephemeral nature of free-droplets, particularly when considering the drying kinetics of droplets with highly volatile constituents, has often precluded the accurate measurement of transient properties such as droplet size and composition, preventing the robust assessment of predictive models of droplet drying rates, nucleation and crystallisation. Here, we report novel measurements of the drying kinetics of individual aqueous sodium chloride solution droplets using a comparative-kinetics electrodynamic balance to isolate and trap single aerosol droplets (radius ~ 25 µm). Read More

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December 2018

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 Dec 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

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December 2018

Economic impact of dengue in Mexico considering reported cases for 2012 to 2016.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.

Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.

Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More

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December 2018

Determining diet from faeces: Selection of metabarcoding primers for the insectivore Pyrenean desman (Galemys pyrenaicus).

PLoS One 2018 14;13(12):e0208986. Epub 2018 Dec 14.

Department of Zoology and Animal Cell Biology, University of the Basque Country UPV/EHU, Leioa, Basque Country, Spain.

Molecular techniques allow non-invasive dietary studies from faeces, providing an invaluable tool to unveil ecological requirements of endangered or elusive species. They contribute to progress on important issues such as genomics, population genetics, dietary studies or reproductive analyses, essential knowledge for conservation biology. Nevertheless, these techniques require general methods to be tailored to the specific research objectives, as well as to substrate- and species-specific constraints. Read More

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December 2018
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The More You Know: Identifying Factors Associated With Inpatient Mortality Related to Opioid Overdose Can Drive Progress in the Opioid Health Crisis.

Anesth Analg 2019 Jan;128(1):16-18

Department of Anesthesiology, University of Michigan School of Medicine, Ann Arbor, Michigan.

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January 2019

The relationship between second language acquisition and nonverbal cognitive abilities.

J Exp Psychol Gen 2018 Dec 13. Epub 2018 Dec 13.

Department of Experimental Psychology.

We monitored the progress of 40 children when they first started to acquire a second language (L2) implicitly through immersion. Employing a longitudinal design, we tested them before they had any notions of an L2 (Time 0) and after 1 school year of L2 exposure (Time 1) to determine whether cognitive abilities can predict the success of L2 learning. Task administration included measures of intelligence, cognitive control, and language skills. Read More

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December 2018

Lean in messages increase attributions of women's responsibility for gender inequality.

J Pers Soc Psychol 2018 Dec;115(6):974-1001

Fuqua School of Business, Duke University.

Although women's underrepresentation in senior-level positions in the workplace has multiple causes, women's self-improvement or "empowerment" at work has recently attracted cultural attention as a solution. For example, the bestselling book states that women can tackle gender inequality themselves by overcoming the "internal barriers" (e.g. Read More

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December 2018

[Progress in the study of artemisinin and its derivatives against head and neck cancer].

Authors:
Y Z Liang X L Nong

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1519-1523

The head and neck cancer is one of the most common malignant tumors in the world. There are more than 600 000 new cases in the world every year. Cisplatin is often used in the treatment of head and neck cancer at present. Read More

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October 2018
2 Reads

[Research progress of biologics in the treatment of chronic rhinosinusitis].

Authors:
Y Liu F Yuan

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1515-1518

Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal airways and paranasal sinuses. The condition is defined by more than 12 weeks of nasal obstruction, nasal discharge, facial pain/pressure, and reduced/lost smell. CRS is commonly further classified into 2 subsets based on its clinical phenotype: those with polyps (CRSwNP) and those without (CRSsNP). Read More

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October 2018

[Application progress of CO₂ in the treatment of laryngology diseases].

Authors:
W B Lei Y Xu J Deng Y Li

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1447-1450

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October 2018
1 Read

[Advances in the treatment of tinnitus].

Authors:
D Wu Y Zheng T Xiang

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1436-1440

Tinnitus is the perception of sound without an external source. Its impact is wide-ranging and heterogeneous across individuals. Since tinnitus is a subjective sensation, the treatment of tinnitus is still in the research and exploration stage at present. Read More

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September 2018

[Research progress on auditory neuropathy spectrum disorder and cochlear implantation in infants and young children].

Authors:
J Y Chen Y X Li

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1120-1124

Auditory neuropathy is a disorder characterized by absent or severely abnormal auditory brainstem response (ABR) with intact outer hair cell function, as evidenced by the presence of evoked otoacoustic emissions and/or cochlear microphonics. Unlike patients with sensory hearing loss who show clinical evidence of impaired outer hair cell function. For ANSD patients, clinical rehabilitation is mainly limited to hearing aid wearing and cochlear implantation. Read More

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[The progress of clinical research on the causes and treatments of pediatric laryngotracheal stenosis].

Authors:
J H Lin Z F Xia

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1114-1119

Pediatric laryngotracheal stenosis is a refractory disease in the present otorhinolaryngological head and neck surgery, including congenital stenosis caused by laryngotracheal deformities and acquired stenosis. The incidence of congenital laryngotracheal malformation has a rising trend.But acquired stenosis is still more common,which is mostly caused by iatrogenic injury (e. Read More

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[Laws regulating transplantation should express the contemporaneity. Questions to the constitutionalist Francesco Paolo Casavola and to the philosophers Remo Bodei and Aldo Masullo about the possibility deciding the destiny of one's own organs at the time one decides on how to die and on contacts between donor families and recipients.]

G Ital Nefrol 2018 Dec;35(6)

Dipartimento di Scienze Mediche Traslazionali, Università della Campania Luigi Vanvitelli, Napoli.

Transplantation represents modernity thus the laws regulating the procedure should be continuously renovated and remodeled in order to take full advantage of progress. The debate is about Law no. 219, December 22, 2017 and on Law no. Read More

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December 2018

Thiol-Disulfide Homeostasis in Cerebral Venous Sinus Thrombosis.

Clin Lab 2018 Oct;64(11)

Background: The objective of this study is to examine thiol-disulfide homeostasis in patients with cerebral venous sinus thrombosis.

Methods: Fifty-three patients diagnosed with cerebral venous sinus thrombosis and 80 healthy volunteers were included in the study. The native thiol and total thiol concentrations were measured with the newly developed automated method. Read More

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October 2018

A New Methodology for Before-After Safety Assessment Using Survival Analysis and Longitudinal Data.

Risk Anal 2018 Dec 14. Epub 2018 Dec 14.

Department of Civil and Urban Engineering, Connected Cities for Smart Mobility towards Accessible and Resilient Transportation (C2SMART) Center, and Center for Urban Science and Progress (CUSP), New York University, Brooklyn, NY, USA.

The widely used empirical Bayes (EB) and full Bayes (FB) methods for before-after safety assessment are sometimes limited because of the extensive data needs from additional reference sites. To address this issue, this study proposes a novel before-after safety evaluation methodology based on survival analysis and longitudinal data as an alternative to the EB/FB method. A Bayesian survival analysis (SARE) model with a random effect term to address the unobserved heterogeneity across sites is developed. Read More

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December 2018

Poly(β-Amino Esters): Synthesis, Formulations, and Their Biomedical Applications.

Adv Healthc Mater 2018 Dec 14:e1801359. Epub 2018 Dec 14.

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Poly(β-amino ester) (abbreviated as PBAE or PAE) refers to a polymer synthesized from an acrylate and an amine by Michael addition and has properties inherent to tertiary amines and esters, such as pH responsiveness and biodegradability. The versatility of building blocks provides a library of polymers with miscellaneous physicochemical and mechanical properties. When used alone or together with other materials, PBAEs can be fabricated into different formulations in order to fulfill various requirements in drug delivery (for instance, gene, anticancer drugs, and antimicrobials delivery) and natural complex mimicry (nanochaperones). Read More

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December 2018
1 Read

30 Years After: CNS Actions of Prolactin: Source, Mechanism and Physiological Significance.

J Neuroendocrinol 2018 Dec 14:e12669. Epub 2018 Dec 14.

Centre for Neuroendocrinology and Department of Anatomy, University, Of Otago Medical School,, Dunedin, New Zealand.

Our understanding of the neural actions of prolactin (PRL) and its biochemical basis has expanded greatly over the past three decades. During this time, major progress has been made that includes the elucidation of how PRL accesses the brain, identification of the PRL receptor and the sites where it is expressed within the brain, determination of the neurochemical mechanism of action of PRL and its effect on genomic expression in neurons, identification of the neural sites where PRL acts to stimulate maternal behavior and related affective states, and exploration of how life experiences impact neural PRL receptor activity and actions. The next 30 years promise to reveal a myriad of basic and clinical findings regarding new roles for PRL and a greater in depth understanding of how and where PRL affects physiological and behavioral processes. Read More

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December 2018

Underaddressed animal-welfare issues in conservation.

Conserv Biol 2018 Dec 14. Epub 2018 Dec 14.

College of Veterinary Medicine, School of Veter…cut the number of references to the best 3inary and Life Sciences, Murdoch University, 90 South St, Murdoch, WA 6160, Australia.

Much progress has been made improving animal welfare in conservation over the past two decades. However, several glaring knowledge gaps remain where animal welfare concerns exist but animal welfare studies have not been performed in politically sensitive contexts. We use examples from Australia to identify four such issues lacking meaningful analysis; the absence of animal welfare oversight for operations designated as "management" (as opposed to research), the lack of consideration for the animal welfare impacts of biological agents that are used to control invasive animals, the paucity of studies to examine the welfare of animals that are hunted recreationally, and the scarcity of studies to examine the animal welfare impacts associated with Indigenous wildlife use. Read More

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December 2018

Fused Aromatic Network Structures as a Platform for Efficient Electrocatalysis.

Adv Mater 2018 Dec 14:e1805062. Epub 2018 Dec 14.

School of Energy and Chemical Engineering, Center for Dimension-Controllable Organic Frameworks, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST, Ulsan, 44919, South Korea.

Fused aromatic network (FAN) structures are a category of ordered porous polymers that permit the specific fusion of building blocks into extended porous network structures with designed skeletons and pores. One significant feature of FANs is that their structures can be tailorable with fused aromatic rings without rotatable single-bond connectivity. As a result, the geometry and space orientation of the building blocks are easily incorporated to guide the topological expansion of the architectural periodicity. Read More

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December 2018
6 Reads

Fruitful first experience with an 8K ultra-high-definition endoscope for laparoscopic colorectal surgery.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Gastrointestinal Surgery, St. Luke's International Hospital, Tokyo, Japan.

We performed laparoscopic surgery for three cases of colorectal cancer using an 8K ultra-high-definition endoscopic system, which offers 16-fold higher resolution than the current 2K high-definition endoscope. The weight of the camera has been successfully reduced to 370 g. To maximize the advantages of the 8K ultra-high-definition endoscope, surgery was performed by darkening the room and placing a large 85-in. Read More

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December 2018

Graphene Oxide as an Optical Biosensing Platform: A Progress Report.

Adv Mater 2018 Dec 14:e1805043. Epub 2018 Dec 14.

Nanobioelectronics and Biosensors Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST, Campus UAB, Bellaterra, 08193, Barcelona, Spain.

A few years ago, crucial graphene oxide (GO) features such as the carbon/oxygen ratio, number of layers, and lateral size were scarcely investigated and, thus, their impact on the overall optical biosensing performance was almost unknown. Nowadays valuable insights about these features are well documented in the literature, whereas others remain controversial. Moreover, most of the biosensing systems based on GO were amenable to operating as colloidal suspensions. Read More

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December 2018

Genome-Wide Maps of Transcription Regulatory Elements and Transcription Enhancers in Development and Disease.

Compr Physiol 2018 Dec 13;9(1):439-455. Epub 2018 Dec 13.

Blood Research Institute, BloodCenter of Wisconsin, a part of Versiti, Milwaukee, Wisconsin, USA.

Gene expression is regulated by numerous elements including enhancers, insulators, transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional start site, called enhancers, play a central role in the temporal and tissue-specific regulation of gene expression through RNA polymerase II. The identification of enhancers and other cis regulatory elements has largely been possible due to advances in next generation sequencing technologies. Read More

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December 2018
2 Reads

A New Era of Cardiac Cell Therapy: Opportunities and Challenges.

Adv Healthc Mater 2018 Dec 13:e1801011. Epub 2018 Dec 13.

Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC, 27607, USA.

Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the most common causes of death in the United States. Over the last few decades, scientists have invested considerable resources on the study and development of cell therapies for myocardial regeneration after MI. However, due to a number of limitations, they are not yet readily available for clinical applications. Read More

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December 2018
2 Reads

Salt stress under the scalpel - Dissecting the genetics of salt tolerance.

Plant J 2018 Dec 12. Epub 2018 Dec 12.

King Abdullah University of Science and Technology (KAUST), Division of Biological and Environmental Sciences and Engineering, Thuwal, 23955-6900, Kingdom of Saudi Arabia.

Salt stress limits the productivity of crops grown under saline conditions, leading to substantial yield losses in saline soils and under brackish and saline irrigation. Salt tolerant crops could alleviate these losses while both increasing irrigation opportunities and reducing agricultural demands on dwindling freshwater resources. However, despite significant efforts, progress towards this goal has been limited, largely because of genetic complexity of salt tolerance for agronomically important yield-related traits. Read More

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December 2018

The Semiconductor/Conductor Interface Piezoresistive Effect in an Organic Transistor for Highly Sensitive Pressure Sensors.

Adv Mater 2018 Dec 13:e1805630. Epub 2018 Dec 13.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Sciences, Tianjin University, Tianjin, 300072, China.

The piezoresistive pressure sensor, a kind of widely investigated artificial device to transfer force stimuli to electrical signals, generally consists of one or more kinds of conducting materials. Here, a highly sensitive pressure sensor based on the semiconductor/conductor interface piezoresistive effect is successfully demonstrated by using organic transistor geometry. Because of the efficient combination of the piezoresistive effect and field-effect modulation in a single sensor, this pressure sensor shows excellent performance, such as high sensitivity (514 kPa ), low limit of detection, short response and recovery time, and robust stability. Read More

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December 2018

A comparison of the EU regulatory approach to directed mutagenesis with that of other jurisdictions, consequences for international trade and potential steps forward.

New Phytol 2018 Dec 13. Epub 2018 Dec 13.

Biotechnology Directorate, Ministry of AgroIndustry, Buenos Aires, Argentina; National University of Quilmes, Bernal, Argentina.

A special regulatory regime applies to products of recombinant nucleic acid modifications. A ruling from the European Court of Justice has interpreted this regulatory regime in a way that it also applies to emerging mutagenesis techniques. Elsewhere regulatory progress is also ongoing. Read More

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December 2018

Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV.

Methods: Embase, PubMed, and Web of Science were searched for relevant studies. Read More

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December 2018

Converging phenomics and genomics to study natural variation in plant photosynthesis efficiency.

Plant J 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Genetics.

In recent years, developments in plant phenomic approaches and facilities have gradually caught up with genomic approaches. An opportunity lies ahead to dissect complex, quantitative traits when both genotype and phenotype can be assessed at a high level of detail. This is especially true for studying natural variation in photosynthesis efficiency, for which forward genetics studies have yielded only little progress in our understanding of the genetic layout of the trait. Read More

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December 2018

Alkenylboronates: synthesis and applications.

Chem Asian J 2018 Dec 12. Epub 2018 Dec 12.

SPAIN.

Organoboron compounds have become one of the most versatile building blocks in organic synthesis due to their accesible and efficient conversion into many different functional groups. In particular, alkenylboronates have received much attention as very reactive substrates in Suzuki-Miyaura cross-coupling reactions. Accordingly, efforts towards the development of efficient methods to prepare this type of compounds are constant. Read More

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December 2018
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