228,758 results match your criteria Progress in community health partnerships : research education and action[Journal]


The latest progress on miR-374 and its functional implications in physiological and pathological processes.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Non-coding RNAs (ncRNAs) have been emerging players in cell development, differentiation, proliferation and apoptosis. Based on their differences in length and structure, they are subdivided into several categories including long non-coding RNAs (lncRNAs >200nt), stable non-coding RNAs (60-300nt), microRNAs (miRs or miRNAs, 18-24nt), circular RNAs, piwi-interacting RNAs (26-31nt) and small interfering RNAs (about 21nt). Therein, miRNAs not only directly regulate gene expression through pairing of nucleotide bases between the miRNA sequence and a specific mRNA that leads to the translational repression or degradation of the target mRNA, but also indirectly affect the function of downstream genes through interactions with lncRNAs and circRNAs. Read More

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http://dx.doi.org/10.1111/jcmm.14219DOI Listing
February 2019

The occurrence, potential toxicity, and toxicity mechanism of bisphenol S, a substitute of bisphenol A: A critical review of recent progress.

Ecotoxicol Environ Saf 2019 Feb 14;173:192-202. Epub 2019 Feb 14.

Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China; State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Bisphenol S (BPS) has been introduced into the industry as a safer alternative to bisphenol A (BPA). The distribution of BPS has recently become an important issue worldwide, but investigations on the toxicity and mechanisms of BPS remain limited. A review of the literature reveals that BPS has widespread presence in environmental media, such as indoor dust, surface water, sediments, and sewage sludge. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.114DOI Listing
February 2019

Algal-based removal strategies for hazardous contaminants from the environment - A review.

Sci Total Environ 2019 Feb 10;665:358-366. Epub 2019 Feb 10.

Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N. L. CP 64849, Mexico. Electronic address:

Owing to the controlled or uncontrolled industrial wastewater disposal, pharmaceutical-based hazardous emerging contaminants (ECs) can be found in the environment all over the world. With ever-increasing socioeconomic aspects and environmental awareness, people are now more concerns about the widespread occurrences of hazardous and persistent contaminants, around the globe. In this context, several studies have already shown that various types of emerging and/or re-emerging contaminants, regardless the source, type and concentration, are of supreme threat to the living system of flora and fauna. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.129DOI Listing
February 2019

Acquired and progressive myelinated retinal nerve fibers in neurofibromatosis type 1.

J AAPOS 2019 Feb 14. Epub 2019 Feb 14.

Hospital de Santa Maria, Lisboa, Portugal; Clínica Universitária de Oftalmologia, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal .

Acquired myelinated retinal nerve fibers (MRNF) is rare. The reported cases occur after optic disk injuries. We describe a case of a patient with neurofibromatosis type 1 and bilateral optic pathway glioma, who after 3 years' follow-up developed unilateral MRNF. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.01.012DOI Listing
February 2019

Early Events in Rabies Virus Infection-Attachment, Entry, and Intracellular Trafficking.

Virus Res 2019 Feb 14. Epub 2019 Feb 14.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, 5333 Xian Road, Changchun 130062, China. Electronic address:

Rabies virus (RABV), an enveloped virus with a single-stranded and negative-sense RNA genome, is the type species of the Lyssavirus Genus within the Rhabdoviridae family. As the causative agent of rabies with a nearly 100% fatality, the neurotropic RABV pose a serious threat to the global public health. Though a great effort has been made toward understanding the molecular mechanism underlying virus infection cycle, there are still many aspects need to be elucidated, especially on the early events during virus replication cycle. Read More

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http://dx.doi.org/10.1016/j.virusres.2019.02.006DOI Listing
February 2019

Estimating HIV incidence from surveillance data indicates a second wave of infections in Brazil.

Epidemics 2019 Feb 7. Epub 2019 Feb 7.

Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, United Kingdom.

Emerging evidence suggests that HIV incidence rates in Brazil, particularly among men, may be rising. Here we use Brazil's integrated health systems data to develop a mathematical model, reproducing the complex surveillance systems and providing estimates of HIV incidence, number of people living with HIV (PLHIV), reporting rates and ART initiation rates. An age-structured deterministic model with a flexible spline was used to describe the natural history of HIV along with reporting and treatment rates. Read More

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http://dx.doi.org/10.1016/j.epidem.2019.02.002DOI Listing
February 2019

Increased cerebrospinal fluid neurofilament light chain in central nervous system inflammatory demyelinating disease.

Mult Scler Relat Disord 2019 Feb 8;30:123-128. Epub 2019 Feb 8.

Navy Clinical College, Anhui Medical University, Hefei, 230032 Anhui, China; Department of Neurology, The Sixth Medical Centre, Chinese People's Liberation Army General Hospital, Beijing, 100048 China. Electronic address:

Background: Central nervous system (CNS) inflammatory demyelinating disease (IDD) is an immune-mediated disease that is pathologically characterized by demyelination and inflammatory infiltration in the CNS and includes clinically isolated syndrome (CIS), multiple sclerosis (MS), and neuromyelitis optica spectrum disorders (NMOSD). IDD is usually characterized by variable symptoms, multivariate imaging, uncertain reactions to treatment, and a variable prognosis, which makes it difficult to diagnose early. In recent years, the role of the neurofilament light chain (NFL), an axonal injury biomarker, in IDD has become increasingly important. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.009DOI Listing
February 2019

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

Acta Biomater 2019 Feb 13. Epub 2019 Feb 13.

Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, PR China; Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan, PR China; Center for Information in Biology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, PR China. Electronic address:

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM stiffness in cancer is well known. However, the biomechanical behavior of tumor cells and the underlying mechanotransduction pathways remain unclear. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.015DOI Listing
February 2019

Viral genome integration of canine papillomavirus 16.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.

Papillomaviruses infect humans and animals, most often causing benign proliferations on skin or mucosal surfaces. Rarely, these infections persist and progress to cancer. In humans, this transformation most often occurs with high-risk papillomaviruses, where viral integration is a critical event in carcinogenesis. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.002DOI Listing
February 2019

Two-dimensional cancer theranostic nanomaterials: Synthesis, surface functionalization and applications in photothermal therapy.

J Control Release 2019 Feb 13. Epub 2019 Feb 13.

SRM Research Institute, SRM Institute of Science and Technology, Kattankulathur 603203, Kanchipuram, India; Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Kattankulathur 603203, Kanchipuram, India. Electronic address:

In recent years, novel two-dimensional (2D) nanomaterials are of great interest for diverse potential applications such as device fabrication, energy storage, sensing and theranostics because of their superlative physical features namely, large surface area, minimal thickness, tunable composition and easier surface modification methods. Rapid exploration in design and fabrication of 2D nano-structures have opened new avenue for cancer theranostics as it can encapsulate group of cancer cells and inflict major damage with great specificity in a non-invasive manner. Among the reported 2D materials such as graphene and its derivatives, metallic compounds, transition metal dichalcogenides (TMDC), black phosphorous and MXenes (e. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.015DOI Listing
February 2019

Complete Atrioventricular Septal Defect - Evolution of Results in a Single Center during 50 years.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatric Cardiac Surgery, Children's Hospital, Helsinki University Hospital, Helsinki University, Finland. Electronic address:

Background: Operative mortality after complete atrioventricular septal defect (cAVSD) repair has improved vastly. Less improvement has been demonstrated regarding late mortality and reoperation rates. There is evident lack of comprehensive population-based studies analyzing the history and progress of the ever-changing operative results. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.020DOI Listing
February 2019

LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.

Cell Death Dis 2019 Feb 15;10(3):159. Epub 2019 Feb 15.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Notwithstanding the researches on biomarkers and targeted therapies in renal cell carcinomas (RCC) have made progress in the last decades, the application of the biomarkers and targeted therapy agents for RCC in clinic are restricted because of their limitation or side effects. Liver X receptors (LXRs) and the NLRP3 inflammasome have been the research hotspots in recent years. In our study, we integrated bioinformatics analysis, molecular biology experiments and biological function experiments to study the roles of LXRα and the NLRP3 inflammasome in RCC. Read More

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http://dx.doi.org/10.1038/s41419-019-1345-3DOI Listing
February 2019

A systematic review of multi-level stigma interventions: state of the science and future directions.

BMC Med 2019 Feb 15;17(1):41. Epub 2019 Feb 15.

Department of Health Behavior, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.

Background: Researchers have long recognized that stigma is a global, multi-level phenomenon requiring intervention approaches that target multiple levels including individual, interpersonal, community, and structural levels. While existing interventions have produced modest reductions in stigma, their full reach and impact remain limited by a nearly exclusive focus targeting only one level of analysis.

Methods: We conducted the first systematic review of original research on multi-level stigma-reduction interventions. Read More

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http://dx.doi.org/10.1186/s12916-018-1244-yDOI Listing
February 2019

[Application Status and Development Trends of Medical Proton and Heavy Ion Accelerators].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):37-42

School of Mechanical and Electronical Engineering, Lanzhou University of Technology, Lanzhou, 730050.

Cancer therapy with accelerated proton or heavy ion beam is the most advanced radiotherapy technology, which is recognized by the international community at present. It is of great practical significance to study the medical proton and heavy ion accelerators and the radiotherapy technology, in order to promote the development of the advanced medical radiotherapy equipments and improve the quality of life of cancer patients in China. After a brief overview of cancer therapy with proton and heavy ion beam, this paper summarized and analyzed the application status of medical proton accelerators and medical heavy ion accelerators at home and abroad, and finally put forward the future development trends of medical proton and heavy ion accelerators and the radiotherapy technology, it can provide a reference for the progress and development strategies of the advanced radiotherapy equipments in China. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.010DOI Listing
January 2019

[Research Progress of Dynamic Musculoskeletal Ultrasound Image Processing].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):32-36

School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060.

Muscle is one of the most important tissues of human body, which is distributed around various organs and bones. Skeletal muscle plays an important role in human activities and its functional changes are closely related to its own morphological structure. The study of the relationship between musculoskeletal structure and function can help us to understand the physiology basics of force and to guide clinical practices. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.009DOI Listing
January 2019
3 Reads

Pulmonary arterial hypertension in adults with systemic right ventricles referred for cardiac transplantation.

Clin Transplant 2019 Feb 15:e13496. Epub 2019 Feb 15.

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Background: Systemic right ventricular [RV] failure may progress necessitating referral for orthotropic heart transplantation [OHT]. Pulmonary hypertension [PH] frequently coexists in adult congenital heart disease and can complicate the assessment for OHT.

Methods: Single-center case series of six patients [median age 34. Read More

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http://dx.doi.org/10.1111/ctr.13496DOI Listing
February 2019

Consensus Building in OMERACT: Recommendations for Use of the Delphi for Core Outcome Set Development.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the University of Ottawa, Departments of Medicine and Innovation in Medical Education; Center for Global Health, University of Ottawa; Division of Rheumatology, Department of Medicine, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute; Centre for Practice-Changing Research, Ottawa Hospital Research Institute; OMERACT, Ottawa; Institute for Work and Health, Toronto, Ontario; Department of Medicine, McGill University, Montreal, Quebec, Canada; University of Liverpool, Department of Biostatistics, COMET, Liverpool, UK; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Sydney Medical School, University of Sydney, Sydney; Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam, the Netherlands. S. Humphrey-Murto, Associate Professor of Medicine, MD, MEd, University of Ottawa, Departments of Medicine and Innovation in Medical Education; R. Crew, BSc (Hons), University of Liverpool, Department of Biostatistics, COMET; B. Shea, PhD, Center for Global Health, University of Ottawa; S.J. Bartlett, PhD, Professor, Department of Medicine, McGill University, and Adjunct Professor, Department of Medicine, Johns Hopkins University; L. March, MBBS, MSc, PhD, FRACP, FAFPHM, Sydney Medical School, University of Sydney, and Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health, and Department of Rheumatology, Royal North Shore Hospital; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; L.J. Maxwell, PhD, Centre for Practice-Changing Research, Ottawa Hospital Research Institute, and University of Ottawa; D. Beaton, BscOT, PhD, Senior Scientist, Institute for Work and Health; S. Grosskleg, OMERACT, and University of Ottawa; M. de Wit, PhD, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health. Address correspondence by Dr. S. Humphrey-Murto, The Ottawa Hospital-Riverside Campus, 1967 Riverside Dr., Ottawa, Ontario, K1H 7W9, Canada. E-mail: Accepted for publication December 6, 2018.

Objective: Developing international consensus on outcome measures for clinical trials is challenging. The following paper will review consensus building in Outcome Measures in Rheumatology (OMERACT), with a focus on the Delphi.

Methods: Based on the literature and feedback from delegates at OMERACT 2018, a set of recommendations is provided in the form of the OMERACT Delphi Consensus Checklist. Read More

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http://dx.doi.org/10.3899/jrheum.181094DOI Listing
February 2019

What Does It Really Look Like to Properly Address a "Human Error Problem" in Biopharma? The Human Performance Blue-Sky Description That Will Help Improve Industry Performance.

PDA J Pharm Sci Technol 2019 Feb 15. Epub 2019 Feb 15.

BioPhorum.

Human Performance is an integrated risk management approach to improving systems, that includes human factors and systems safety, that leads to higher reliability and enhanced operational resilience. A clear picture of what Human Performance looks like in biopharma is available from the BioPhorum Operations Group (BPOG), where members of the Human Performance workstream have defined a blue-sky for the industry. This blue-sky document is both a guide and an assessment tool that will help to identify the steps to effective human performance integration with operations. Read More

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http://dx.doi.org/10.5731/pdajpst.2018.009621DOI Listing
February 2019

Multimodal Action of Mas Activation for Systemic Cancer Cachexia Therapy.

Cancer Res 2019 Feb;79(4):699-700

Department of Biochemistry and Molecular Biology, Indianapolis, Indiana.

Cancer cachexia remains a largely intractable, deadly condition for patients with no approved, effective therapies. However, research progress over the past few decades demonstrates that cachexia is a disease with specific, targetable mechanisms. New work by Murphy and colleagues in this issue of suggests that activation of the alternative renin-angiotensin system with the nonpeptide Mas receptor agonist AVE 0991 holds promise for reducing muscle wasting in cancer. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3910DOI Listing
February 2019

Systematic review of the role of corticosteroids in cervicofacial infections.

Br J Oral Maxillofac Surg 2019 Feb 12. Epub 2019 Feb 12.

Maxillofacial surgery Trainees Research Collaborative, Queen Elizabeth University Hospital, Glasgow.

The role of corticosteroids in the management of cervicofacial infections continues to cause controversy. Systemic anti-inflammatory and immunomodulatory effects that reduce swelling and improve symptoms in the head and neck may make these agents an effective addition to the antibiotics used and to surgical management, although this same effect may dull the physiological response to infection, and allow infections to progress. We have systematically reviewed the evidence for the use of corticosteroids in common cervicofacial infections following the PRISMA guidelines. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.01.010DOI Listing
February 2019

Advances in the experimental exploration of water's phase diagram.

J Chem Phys 2019 Feb;150(6):060901

Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.

Water's phase diagram displays enormous complexity with currently 17 experimentally confirmed polymorphs of ice and several more predicted computationally. For almost 120 years, it has been a stomping ground for scientific discovery, and ice research has often been a trailblazer for investigations into a wide range of materials-related phenomena. Here, the experimental progress of the last couple of years is reviewed, and open questions as well as future challenges are discussed. Read More

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http://dx.doi.org/10.1063/1.5085163DOI Listing
February 2019

Current Therapeutic Results and Treatment Options for Older Patients with Relapsed Acute Myeloid Leukemia.

Cancers (Basel) 2019 Feb 14;11(2). Epub 2019 Feb 14.

Division of Hematology, Spedali Civili, 25123 Brescia, Italy.

Considerable progress has been made in the treatment of acute myeloid leukemia (AML). However, current therapeutic results are still unsatisfactory in untreated high-risk patients and poorer in those with primary refractory or relapsed disease. In older patients, reluctance by clinicians to treat unfit patients, higher AML cell resistance related to more frequent adverse karyotype and/or precedent myelodysplastic syndrome, and preferential involvement of chemorefractory early hemopoietic precursors in the pathogenesis of the disease further account for poor prognosis, with median survival lower than six months. Read More

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http://dx.doi.org/10.3390/cancers11020224DOI Listing
February 2019

From Human Cytogenetics to Human Chromosomics.

Authors:
Thomas Liehr

Int J Mol Sci 2019 Feb 14;20(4). Epub 2019 Feb 14.

Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747 Jena, Germany.

Background: The concept of "chromosomics" was introduced by Prof. Uwe Claussen in 2005. Herein, the growing insights into human chromosome structure finally lead to a "chromosomic view" of the three-dimensional constitution and plasticity of genes in interphase nuclei are discussed. Read More

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http://dx.doi.org/10.3390/ijms20040826DOI Listing
February 2019

Detecting Multi-Resolution Pedestrians Using Group Cost-Sensitive Boosting with Channel Features.

Sensors (Basel) 2019 Feb 14;19(4). Epub 2019 Feb 14.

School of Computer and Communication Engineering, University of Science and Technology Beijing, Beijing 100083, China.

Significant progress has been achieved in the past few years for the challenging task of pedestrian detection. Nevertheless, a major bottleneck of existing state-of-the-art approaches lies in a great drop in performance with reducing resolutions of the detected targets. For the boosting-based detectors which are popular in pedestrian detection literature, a possible cause for this drop is that in their boosting training process, low-resolution samples, which are usually more difficult to be detected due to the missing details, are still treated equally importantly as high-resolution samples, resulting in the false negatives since they are more easily rejected in the early stages and can hardly be recovered in the late stages. Read More

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http://dx.doi.org/10.3390/s19040780DOI Listing
February 2019

Current Progress in Uterus Transplantation Research in Asia.

J Clin Med 2019 Feb 14;8(2). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.

Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. Read More

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http://dx.doi.org/10.3390/jcm8020245DOI Listing
February 2019
1 Read

Influence of Intra-Oral Scanner (I.O.S.) on The Marginal Accuracy of CAD/CAM Single Crowns.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Department of Dentistry, IRCCS San Raffaele Hospital and Dental School, Vita Salute University, 20123 Milan, Italy.

The aim of this in vitro study was to compare the quality of digital workflows generated by different scanners (Intra-oral digital scanners (I.O.S. Read More

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http://dx.doi.org/10.3390/ijerph16040544DOI Listing
February 2019

Mechanisms and regulation of dopamine release.

Curr Opin Neurobiol 2019 Feb 12;57:46-53. Epub 2019 Feb 12.

Department of Neurobiology, Harvard Medical School, United States. Electronic address:

Dopamine controls motor functions, motivation, and reward-related learning through G-protein coupled receptor signaling. The current working model is that upon release, dopamine diffuses to influence many target cells via wide-spread receptors. Recent studies, however, suggest that dopamine release is fast and generates small signaling hotspots. Read More

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http://dx.doi.org/10.1016/j.conb.2019.01.001DOI Listing
February 2019

Augmenting the synergies of chemotherapy and immunotherapy through drug delivery.

Acta Biomater 2019 Feb 12. Epub 2019 Feb 12.

Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, Georgia, 30332, United States; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, Georgia, 30332, United States; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr NW, Atlanta, Georgia, 30332, United States; Emory University, 201 Dowman Drive, Atlanta, Georgia, 30322, United States; Emory University School of Medicine, 1365-C Clifton Road NE, Winship Cancer Institute, Atlanta, Georgia, 30322, United States. Electronic address:

Despite the recent approvals of multiple cancer immunotherapies, low tumor immunogenicity and immunosuppressive tumor microenvironments prevent a large portion of patients from responding to these treatment modalities. Given the immunomodulatory and adjuvant effects of conventional chemotherapy as well as its widespread clinical use, the use of chemotherapy in combination with immunotherapy (so-called chemoimmunotherapy) is an attractive approach to potentiate the effects of immunotherapy in more patient populations. However, due to the limited extent of tumor accumulation, poorly controlled interactions with the immune system, and effects on systemic healthy tissues by chemotherapeutic drugs, the incorporation of anti-cancer agents into biomaterial-based structures, such as nanocarriers, is highly attractive to improve the safety and efficacy of chemoimmunotherapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193011
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http://dx.doi.org/10.1016/j.actbio.2019.02.012DOI Listing
February 2019
2 Reads

Calcium Dobesilate and Micro-vascular diseases.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Xuzhou 221002, China. Electronic address:

Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement lead to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate Drug (CAD) is an established vasoactive and angioprotective drug that has shown a unique, multitarget mode of action in several experimental studies and in different animal models of diabetic microvascular complications. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.023DOI Listing
February 2019

Rationally designed DNA-based nanocarriers.

Adv Drug Deliv Rev 2019 Feb 12. Epub 2019 Feb 12.

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Nanomaterials employed for enhanced drug delivery and therapeutic effects have been extensively investigated in the past decade. The outcome of current anticancer treatments based on conventional nanoparticles is suboptimal, due to the lack of biocompatibility, the deficient tumor targeting, the limited drug accumulation in the diseased region, etc. Alternatively, DNA-based nanocarriers have emerged as a novel and versatile platform to integrate the advantages of nanotechnologies and biological sciences, which shows great promise in addressing the key issues for biomedical studies. Read More

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http://dx.doi.org/10.1016/j.addr.2019.02.003DOI Listing
February 2019

miR-26b modulates OA induced BMSC osteogenesis through regulating GSK3β/β-catenin pathway.

Exp Mol Pathol 2019 Feb 12. Epub 2019 Feb 12.

Department of Orthopedics, Beijing Northern Hospital, China North Industries, Beijing 100089, PR.China.; Inner Mongolia Medical University, Hohhot 014010, Inner Mongolia, PR.China.. Electronic address:

Backgrounds: Osteoactivin (OA) is a key regulator promoting bone marrow stromal cells osteogenesis progress, while Dexamethasone (Dex) could inhibit OA induced osteogenesis and lead to osteoporosis. miR-26b increased during BMSC osteogenesis but whether it participates in this progress is enigma. Osteogenesis is under regulation of canonical Wnt signaling pathway which could serve as potential target for miR-26b. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.02.003DOI Listing
February 2019

Towards an atomic-scale understanding of electrochemical interface structure and dynamics.

J Am Chem Soc 2019 Feb 15. Epub 2019 Feb 15.

For the knowledged-based development of electrochemical processes, a better fundamental understanding of the interfaces between electrodes and electrolytes is necessary. This requires insight into the interface structure and dynamics on the atomic-scale, including that of the liquid electrolyte in the near-surface region, i.e. Read More

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http://dx.doi.org/10.1021/jacs.8b13188DOI Listing
February 2019

Spinning and Applications of Bioinspired Fiber Systems.

ACS Nano 2019 Feb 15. Epub 2019 Feb 15.

Natural fiber systems provide inspirations for artificial fiber spinning and applications. Through a long process of trial and error, great progress has been made in recent years. The natural fiber itself, especially silks, and the formation mechanism are better understood, and some of the essential factors are implemented in artificial spinning methods, benefiting from advanced manufacturing technologies. Read More

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http://dx.doi.org/10.1021/acsnano.8b09651DOI Listing
February 2019

Bioluminescence Resonance Energy Transfer 2 (BRET2)-Based RAS Biosensors to Characterize RAS Inhibitors.

Curr Protoc Cell Biol 2019 Feb 15:e83. Epub 2019 Feb 15.

Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

Protein-protein interactions (PPIs) are principle biological processes that control normal cell growth, differentiation, and homeostasis but are also crucial in diseases such as malignancy, neuropathy, and infection. Despite the importance of PPIs in biology, this target class has been very challenging to convert to therapeutics. In the last decade, much progress has been made in the inhibition of PPIs involved in diseases, but many remain difficult such as RAS-effector interactions in cancers. Read More

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http://doi.wiley.com/10.1002/cpcb.83
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http://dx.doi.org/10.1002/cpcb.83DOI Listing
February 2019
2 Reads

Patient Perspectives on Smoking Cessation and Interventions in Rheumatology Clinics.

Arthritis Care Res (Hoboken) 2019 Feb 15. Epub 2019 Feb 15.

UW-SMPH Department of Medicine, Rheumatology, Madison, WI, United States.

Objective: Although smoking is a risk factor for cardiovascular and rheumatic disease severity, only 10% of rheumatology visits document cessation counseling. After implementing a rheumatology clinic protocol that increased tobacco quitline referrals 20-fold, current objectives were to 1) examine patients' barriers and facilitators to smoking cessation based on prior rheumatology experiences, 2) solicit reactions to the new cessation protocol, and 3) identify patient-centered outcomes or "signs of cessation progress" following improved care.

Methods: We recruited 19 patients who smoke-12 with rheumatoid arthritis (RA) and 7 with systemic lupus erythematosus (SLE)-to one of three semi-structured focus groups. Read More

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http://dx.doi.org/10.1002/acr.23858DOI Listing
February 2019

MACROCYCLIC PEPTIDES AS DRUG CANDIDATES: RECENT PROGRESS AND REMAINING CHALLENGES.

J Am Chem Soc 2019 Feb 15. Epub 2019 Feb 15.

Peptides as a therapeutic modality attract much attention due to their synthetic accessibility, high degree of specific binding, and the ability to target protein surfaces traditionally considered "undruggable". Unfortunately, at the same time, other pharmacological properties of a generic peptide, such as metabolic stability and cell permeability, are quite poor, which limits the success of de novo discovered biologically active peptides as drug candidates. Here, we review how macrocyclization as well as the incorporation of non-proteogenic amino acids and various conjugation strategies may be utilized to improve on these characteristics to create better drug candidates. Read More

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http://dx.doi.org/10.1021/jacs.8b13178DOI Listing
February 2019
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Recent advances in the synthesis of C2-spiropseudoindoxyls.

Org Biomol Chem 2019 Feb 15. Epub 2019 Feb 15.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People's Republic of China.

Compared with the numerous reviews on the construction of C3 spirooxindoles, few reviews have examined the synthesis of structurally analogous C2-spiropseudoindoxyl derivatives. This scaffold has attracted substantial attention from synthetic chemists because of its relevance to medicinal chemistry. This review summarizes the recent progress in the synthesis of many heterocycle and carbocycle fused spiropseudoindoxyl compounds. Read More

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http://dx.doi.org/10.1039/c8ob03122cDOI Listing
February 2019

Highly efficient cladding-pumped single-mode three-level Yb all-solid photonic bandgap fiber lasers.

Opt Lett 2019 Feb;44(4):807-810

Efficient cladding-pumped three-level Yb fiber lasers are difficult to achieve due to the competing four-level system and necessary high inversions. We demonstrate an efficiency of ∼62.7% versus a coupled pump, a record for cladding-pumped fiber lasers with a single-pass pump. Read More

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http://dx.doi.org/10.1364/OL.44.000807DOI Listing
February 2019

Assessing the content and comprehensiveness of provincial and territorial indoor tanning legislation in Canada.

Health Promot Chronic Dis Prev Can 2019 Feb;39(2):45-55

Department of Population Medicine, University of Guelph, Guelph, Ontario, Canada.

Introduction: Canadian provincial and territorial governments have enacted legislation in response to health risks of artificial ultraviolet radiation from indoor tanning. This legislation, which differs from jurisdiction to jurisdiction, regulates the operation of indoor tanning facilities. The content and comprehensiveness of such legislation-and its differences across jurisdictions-have not been analyzed. Read More

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http://dx.doi.org/10.24095/hpcdp.39.2.02DOI Listing
February 2019

Characterising variations in perceptual decision making.

Behav Brain Sci 2018 Jan;41:e241

Department of Psychiatry and Division of Medical Psychology,University of Bonn Medical Center,53105

Current perspectives propose that observer models accounting for both optimal and suboptimal behaviour may yield real progress in understanding perception. We propose that such models could, in addition, be very useful for precisely characterising the variation in perception across healthy participants and those affected by psychiatric disorders, as well as the effects of neuromodulators such as oxytocin. Read More

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http://dx.doi.org/10.1017/S0140525X18001371DOI Listing
January 2018

The standard Bayesian model is normatively invalid for biological brains.

Behav Brain Sci 2018 Jan;41:e237

Department of Neurophysiology and Pathophysiology,University Medical Center Hamburg-Eppendorf,20246

We show that the benchmark Bayesian framework that Rahnev & Denison (R&D) used to assess optimality is actually suboptimal under realistic assumptions about how noise corrupts decision making in biological brains. This model is therefore invalid qua normative standard. We advise against generally forsaking optimality and argue that a biologically constrained definition of optimality could serve as an important driver for scientific progress. Read More

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http://dx.doi.org/10.1017/S0140525X18001449DOI Listing
January 2018

Role of metabolomics in identification of biomarkers related to food intake.

Proc Nutr Soc 2019 Feb 15:1-8. Epub 2019 Feb 15.

UCD School of Agriculture and Food Science,Institute of Food and Health, UCD,Belfield, Dublin 4,Ireland.

Dietary assessment methods including FFQ and food diaries are associated with many measurement errors including energy under-reporting and incorrect estimation of portion sizes. Such errors can lead to inconsistent results especially when investigating the relationship between food intake and disease causation. To improve the classification of a person's dietary intake and therefore clarify proposed links between diet and disease, reliable and accurate dietary assessment methods are essential. Read More

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http://dx.doi.org/10.1017/S002966511900048XDOI Listing
February 2019

New Insights in Cannabinoid Receptor Structure and Signaling.

Curr Mol Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Biochemistry and Molecular Biology, College of Life Sciences, Zhejiang University, Zijingang Campus, Hangzhou, Zhejiang. China.

Background: Cannabinoid has long been used for medicinal purposes. Cannabinoid signaling has been considered the therapeutic targets for treating pain, addiction, obesity, inflammation, and other diseases. Recent studies have suggested that in addition to CB1 and CB2, there are non-CB1 and non-CB2 cannabinoid-related orphan GPCRs including GPR18, GPR55, and GPR119. Read More

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http://dx.doi.org/10.2174/1874467212666190215112036DOI Listing
February 2019

Nanocarriers for vaginal drug delivery.

Recent Pat Drug Deliv Formul 2019 Feb 15. Epub 2019 Feb 15.

Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Bhubaneswar -751023, Odisha. India.

Background: Vaginal drug delivery approach represents one of the imperative strategies for local and systemic delivery of drugs. The peculiar dense vascular networks, mucus permeability, range of physiological characteristics of the vaginal cavity have been exploited for therapeutic benefit. Furthermore, the vaginal drug delivery has been curtailed due to the influence of different physiological factors like acidic pH, constant cervical secretion, microflora, cyclic changes during periods along with turnover of mucus of varying thickness. Read More

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http://dx.doi.org/10.2174/1872211313666190215141507DOI Listing
February 2019

Therapeutic Potential of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood.

Curr Stem Cell Res Ther 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics and Gynaecology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan. China.

Endothelial progenitor cells (EPCs) are implicated in mutiple biologic processes such as vascular homeostasis, neovascularization and tissue regeneration, and tumor angiogenesis. A subtype of EPCs is referred to as endothelial colony-forming cells (ECFCs), which display robust clonal proliferative potential and can form durable and functional blood vessels in animal models. In this review, we provide a brief overview of EPCs' characteristics, classification and origins, a summary of the progress in preclinical studies as regard to the therapeutic potential of human umbilical cord blood derived ECFCs (CB-ECFCs) for ischemia repair, tissue engineering and tumor, and highlight the necessity to select high proliferative CB-ECFCs and to optimize their recovery and expansion conditions. Read More

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http://dx.doi.org/10.2174/1574888X14666190214162453DOI Listing
February 2019

Recent Development on Anti-Obesity Compounds and Their Mechanisms of Action: A Review.

Curr Med Chem 2019 Feb 14. Epub 2019 Feb 14.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Drug Research Institute, School of Pharmacy, Hunan University of Chinese Medicine,Changsha, 410208. China.

Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. In spite of the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of novel and known compounds have at least partially been revealed. Read More

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http://dx.doi.org/10.2174/0929867326666190215114359DOI Listing
February 2019

Decomposition of volatile organic compounds using corona discharge plasma technology.

J Air Waste Manag Assoc 2019 Feb 15. Epub 2019 Feb 15.

c Guangdong Environmental Monitoring Center , Guangzhou , 510308 , China.

The application of corona plasma technology, as a tool in treatment of volatile organic compounds (VOCs), is systematically discussed in the present paper. This review introduces the principle of corona discharge, the characteristics of plasma, emphasis on the characteristic of various corona plasma reactors. Through summarizing the main features of corona plasma reactors, this paper provides a brief background to different power sources and reactor configurations and their application to VOCs treatment design. Read More

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http://dx.doi.org/10.1080/10962247.2019.1582441DOI Listing
February 2019

Recent advancements in the minimally invasive management of esophageal perforation, leaks and fistulae.

Expert Rev Med Devices 2019 Feb 15. Epub 2019 Feb 15.

d Staff, Cleveland Clinic Foundation, Thoracic and Cardiovascular Surgery , Cleveland , OH , USA.

Introduction: Historically, the gold standard management of esophageal perforations, leaks, and fistulae has been traditional open surgery but it is associated with significant morbidity and mortality. Minimally invasive approaches offer alternatives to surgery in treating hemodynamically stable patients with such defects. In this review article, we will discuss the recent advancements in the minimally invasive management of esophageal perforations, leaks, and fistulas. Read More

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http://dx.doi.org/10.1080/17434440.2019.1582329DOI Listing
February 2019

Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?

Drug Dev Ind Pharm 2019 Feb 15:1-26. Epub 2019 Feb 15.

a School of Biomedical Sciences, Faculty of medicine , The University of Queensland , St Lucia , 4072 , Australia.

Pulmonary infections the most common cause of death globally. However, the development of mucosal vaccines that provide protective immunity against respiratory pathogens are limited. In contrast to needle-based vaccines, efficient vaccines that are delivered via non-invasive mucosal routes (such as via the lungs and nasal passage) produce both antigen-specific local mucosal IgA and systemic IgG protective antibodies. Read More

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https://www.tandfonline.com/doi/full/10.1080/03639045.2019.1
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http://dx.doi.org/10.1080/03639045.2019.1583758DOI Listing
February 2019
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