2,214 results match your criteria Progress in cardiovascular diseases[Journal]


Sudden death related cardiomyopathies - hypertrophic cardiomyopathy.

Prog Cardiovasc Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine (ZDG, HC), Johns Hopkins University School of Medicine; Baltimore, MD; Division of Cardiology (HC), Johns Hopkins University School of Medicine; Baltimore, MD. Electronic address:

Hypertrophic cardiomyopathy (HCM) is a form of inherited cardiomyopathy. Most individuals with HCM experience minimal symptoms throughout their lifetime. However, those with HCM are at risk of ventricular arrhythmias and sudden cardiac death (SCD), the most feared complication of HCM. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.04.001DOI Listing
April 2019
3 Reads

Sudden Death Related Cardiomyopathies - Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic Cardiomyopathy, and Exercise-Induced Cardiomyopathy.

Prog Cardiovasc Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America. Electronic address:

Sudden cardiac death (SCD) is a devastating possible outcome of all cardiomyopathies. The risk of SCD is increased in patients with structural heart disease and continues to increase as ventricular dysfunction worsens. There is however a subset of cardiomyopathy, so-called "arrhythmogenic cardiomyopathy" (ACM), that carries an inherent propensity for arrhythmia in all stages of the disease, even preceding ventricular dysfunction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00330620193007
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http://dx.doi.org/10.1016/j.pcad.2019.04.002DOI Listing
April 2019
1 Read

Can cardiac resynchronization therapy be used as a tool to reduce sudden cardiac arrest risk?

Prog Cardiovasc Dis 2019 Apr 17. Epub 2019 Apr 17.

Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.

Patients with cardiomyopathy and reduced left ventricular (LV) ejection fraction are at risk of heart failure (HF) symptoms and sudden cardiac arrest (SCA). In selected HF patients, cardiac resynchronization therapy (CRT) provides LV reverse remodeling and improves the cellular and molecular function. However controversial results have been published regarding the effect of CRT on the residual ventricular arrhythmia risk. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00330620193007
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http://dx.doi.org/10.1016/j.pcad.2019.04.004DOI Listing
April 2019
1 Read

Evolution of extravascular implantable defibrillator technologies.

Prog Cardiovasc Dis 2019 Apr 17. Epub 2019 Apr 17.

Division of Cardiology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Electronic address:

The implantable cardioverter-defibrillator (ICD) has been successfully treating patients with lethal ventricular arrhythmias for decades. The main acute and chronic complications of this therapy modality are related to the use of a transvenous lead. An entirely extravascular ICD concept was developed over the last 20 years, with emergence of the subcutaneous ICD (S-ICD). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00330620193007
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http://dx.doi.org/10.1016/j.pcad.2019.04.003DOI Listing
April 2019
1 Read

Diabetic cardiomyopathy - A comprehensive updated review.

Prog Cardiovasc Dis 2019 Mar 25. Epub 2019 Mar 25.

Department of Internal Medicine, Division of Cardiology, East Tennessee State University, Johnson City, TN, USA. Electronic address:

Diabetes causes cardiomyopathy and increases the risk of heart failure independent of hypertension and coronary heart disease. This condition called "Diabetic Cardiomyopathy" (DCM) is becoming a well- known clinical entity. Recently, there has been substantial research exploring its molecular mechanisms, structural and functional changes, and possible development of therapeutic approaches for the prevention and treatment of DCM. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.03.003DOI Listing
March 2019
2.418 Impact Factor

Exercise Reveals Proline Dehydrogenase as a Potential Target in Heart Failure.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):193-202. Epub 2019 Mar 10.

K.G. Jebsen Center of Exercise in Medicine at the Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

The benefits of physical activity in cardiovascular diseases have long been appreciated. However, the molecular mechanisms that trigger and sustain the cardiac benefits of exercise are poorly understood, and it is anticipated that unveiling these mechanisms will identify novel therapeutic targets. In search of these mechanisms we took advantage of unbiased RNA-sequencing (RNA-seq) technology to discover cardiac gene targets whose expression is disrupted in heart failure (HF) and rescued by exercise in a rat model. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.03.002DOI Listing
April 2019
1 Read

Exercise in medicine.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):85. Epub 2019 Mar 10.

K.G. Jebsen Center of Exercise in Medicine at the Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.pcad.2019.03.001DOI Listing

A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):172-178. Epub 2019 Mar 4.

Massachusetts General Hospital, Harvard Medical School, Boston, United States of America; Broad Institute of MIT and Harvard, Cambridge, Boston, United States of America; Harvard Stem Cell Institute, Cambridge, MA, United States of America; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United States of America. Electronic address:

The beneficial effects of exercise on the brain are well known. However, the underlying molecular mechanisms are much less well understood. Interestingly, myokines, hormones secreted by muscle in response to exercise, gained attention as such beneficial mediators. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.02.007DOI Listing
April 2019
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Global physical activity levels - Need for intervention.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):102-107. Epub 2019 Feb 22.

Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.

Substantial evidence shows that physical inactivity (PI) and sedentary behavior (SB) increases the risk of many chronic diseases and shortens life expectancy. We describe evidence that certain domains of physical activity (PA) in the United States (US) population have declined substantially over 5 decades. The prevalence of PI is very high worldwide, which has contributed to 6%-10% of the burden of many chronic diseases and premature mortality. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.02.004DOI Listing
April 2019
2 Reads

Are the neuroprotective effects of exercise training systemically mediated?

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):94-101. Epub 2019 Feb 22.

The Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Norway.

To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate cognitive impairment and reduce dementia risk. Such benefits have recently been linked to systemic neurotrophic factors induced by exercise. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.02.003DOI Listing
April 2019
10 Reads

Personal Activity Intelligence (PAI): A new standard in activity tracking for obtaining a healthy cardiorespiratory fitness level and low cardiovascular risk.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):179-185. Epub 2019 Feb 22.

K. G. Jebsen Center of Exercise in Medicine at the Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Despite all the evidence of health benefits related to physical activity (PA) and cardiorespiratory fitness (CRF), low levels of PA have reached pandemic proportions, and inactivity is the fourth leading cause of death worldwide. Lack of time, and inability to self-manage are often cited as main barriers to getting adequate PA. Recently, a new personalized metric for PA tracking named Personal Activity Intelligence (PAI) was developed with the aim to make it easier to quantify how much PA per week is needed to reduce the risk of premature mortality from non-communicable diseases. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.02.006DOI Listing
April 2019
1 Read

Curing breast cancer and killing the heart: A novel model to explain elevated cardiovascular disease and mortality risk among women with early stage breast cancer.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):116-126. Epub 2019 Feb 22.

Integrated Cardiovascular Exercise Physiology and Rehabilitation Laboratory, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, USA. Electronic address:

Due to advances in prevention, early detection and treatment, early breast cancer mortality has decreased by nearly 40% during the last four decades. Yet, the risk of cardiovascular disease (CVD) mortality is significantly elevated following a breast cancer diagnosis, and it is a leading cause of death in this population. This review will discuss the most recent evidence for risks, pathology, mechanisms, and prevention of CVD morbidity and mortality in women with breast cancer. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.02.002DOI Listing
April 2019
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Physical activity, exercise and cardiac troponins: Clinical implications.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):108-115. Epub 2019 Feb 22.

Division of Medicine, Akershus University Hospital, Oslo, Norway; Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

Cardiac troponins constitute essential components of the cardiac contractile apparatus and are released into the bloodstream following cardiomyocyte injury. Because of their cardiac specificity, cardiac troponin I or T are the recommended biomarkers for diagnosing acute myocardial infarction. However, cardiac troponin concentrations also frequently increase acutely after strenuous prolonged exercise, making the interpretation of cardiac troponin test results in patients presenting with acute chest pain challenging. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.02.005DOI Listing

Active 10 - A new approach to increase physical activity in inactive people in England.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):135-139. Epub 2019 Feb 21.

Centre for Physical Activity and Health Research, Ulster University, UK.

Public health physical activity (PA) guidelines are failing to increase levels of population PA, requiring a new approach. A national integrated marketing campaign was developed based on published literature and ethnographic research to get inactive lower socioeconomic 40-60 year olds to walk briskly for bouts of 10 or more minutes per day and move towards recommended levels of PA. National and local communications campaigns and partnerships promoted key messages and directed people to a free mobile phone app that provided the user with time, intensity and periodicity of walking, and included goal setting and encouragement to support behaviour change. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.02.001DOI Listing

Non-alcoholic fatty liver disease: Prevalence and all-cause mortality according to sedentary behaviour and cardiorespiratory fitness. The HUNT Study.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):127-134. Epub 2019 Feb 21.

K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Sor Trondelag, Norway; School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, QLD, Australia.

Purpose: Sedentary behaviour (SB) and low physical activity (PA) are independently associated with non-alcoholic fatty liver disease (NAFLD). Compared to PA, high cardiorespiratory fitness (CRF) has been associated with a higher protection against all-cause mortality and a number of specific diseases. However, this relationship has not been investigated in NAFLD. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.01.005DOI Listing
April 2019
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Guidelines for the delivery and monitoring of high intensity interval training in clinical populations.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):140-146. Epub 2019 Jan 24.

University of Queensland, School of Human Movement and Nutrition Sciences, Brisbane, Queensland, Australia.

High intensity interval training (HIIT) is now recognized in international clinical-based exercise guidelines as an appropriate and beneficial adjunct to moderate intensity continuous training. HIIT involves alternating periods of high intensity aerobic exercise with light recovery exercise or no exercise, allowing for greater physiological stimulus and adaptation than moderate intensity continuous training (MICT) for cardiorespiratory fitness and other cardiometabolic processes. However, there is no universal criteria or framework for the prescription and monitoring of HIIT in clinical populations, and safety concerns remain a common barrier for implementing HIIT as standard care. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.01.004DOI Listing
April 2019
6 Reads

Implementing behaviour change theory and techniques to increase physical activity and prevent functional decline among adults aged 61-70: The PreventIT project.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):147-156. Epub 2019 Jan 24.

School of Health Sciences, University of Manchester, Manchester Academic Health, Science Centre, Manchester, UK; Manchester University NHS Foundation Trust.

The health and wellbeing benefits of engaging in physical activity (PA), and of improving strength and balance, are well documented. The World Health Organization's recommendations of 150 min per week of moderate intensity physical activity have been adopted across the world in policy and practice recommendations. However, the number of older adults engaging in this level of PA remains low. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.01.003DOI Listing
April 2019
4 Reads

Precision medicine and healthy living: The importance of the built environment.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):34-38. Epub 2019 Jan 9.

School of Health Sciences, College of Health and Medicine, University of Tasmania, TAS, Australia.

The built environment encompasses the major physical spaces, including buildings, streets, homes, schools, parks, playgrounds and other infrastructure in which we live, work and play. In an ideal world, the built environment should support and facilitate a healthy engagement in physical activity across the lifespan. However, in the context of an environment characterized by increased mechanization and urbanization, physical inactivity and higher levels of overweight and obesity, too many settings are not conducive to physical activity and/or are not safe and walkable. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.013DOI Listing
March 2019
1 Read

Cardiorespiratory fitness and cardiovascular disease - The past, present, and future.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):86-93. Epub 2019 Jan 9.

School of Kinesiology and Health Studies, Department of Medicine, Division of Endocrinology and Metabolism, Queens University, Ontario, Canada.

The importance of cardiorespiratory fitness (CRF) is now well established and it is increasingly being recognized as an essential variable which should be assessed in health screenings. The key findings that have established the clinical significance of CRF are reviewed in this report, along with an overview of the current relevance of exercise as a form of medicine that can provide a number of positive health outcomes, including increasing CRF. Current assessment options for assessing CRF are also reviewed, including the direct measurement via cardiopulmonary exercise testing which now can be interpreted with age and sex-specific reference values. Read More

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http://dx.doi.org/10.1016/j.pcad.2019.01.002DOI Listing
April 2019
1 Read

Five Years as Editor-in-Chief.

Authors:
Carl J Lavie

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):83-84. Epub 2019 Jan 6.

John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA. Electronic address:

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http://dx.doi.org/10.1016/j.pcad.2019.01.001DOI Listing
March 2019
1 Read

Precision Measurements to Assess Baseline Status and Efficacy of Healthy Living Medicine.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):55-59. Epub 2019 Jan 3.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, United States of America; Integrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, United States of America. Electronic address:

Precision medicine recently has gained popularity, calling for more individualized approaches to prevent and/or reduce chronic-disease risk and to reduce non-communicable diseases such as cardiovascular disease (CVD). Encompassed under Precision medicine initiatives is the concept of healthy living medicine (HLM), which emphasizes the promotion of lifestyle and behavioral practices including physical activity and healthy dietary pattern. Precision measurements have the potential to improve the understanding of how risk factors influence disease trajectory, and further inform on how to precisely tailor clinical strategies to manage risk factors to prevent disease manifestation, and refine therapies according the patient's demographic, environment, and disease etiology. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.011DOI Listing
March 2019
1 Read

Furthering Precision Medicine Genomics With Healthy Living Medicine.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):60-67. Epub 2019 Jan 2.

Florida Hospital Translational Research Institute for Metabolism and Diabetes, 301 East Princeton Street, Orlando, FL 32804, USA.

The Precision Medicine Initiative seeks to develop new approaches for disease treatment and prevention that considers the individual variation in genes, environment, and lifestyle for each person. To date, the focus has been on genetic drivers of disease risk and development but has now begun to incorporate lifestyle induced changes in phenotype to enhance treatments. Healthy Living Medicine is an emerging paradigm that focuses on moving more and sitting less, consuming a healthy diet, maintaining body weight and not smoking. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.009DOI Listing
March 2019
2 Reads

Outcomes of Healthy Eating Ad Campaigns: A Systematic Review.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):39-43. Epub 2019 Jan 2.

Assistant Professor and Head Librarian, Richard J. Daley Library, University of Illinois at Chicago, 801 S Morgan St, Chicago, IL 60607, United States of America. Electronic address:

Social marketing campaigns seeking to promote healthy eating hold promise in precision messaging and behavior change related to a key component of healthy living medicine. A systematic review that examines the behaviors promoted against their success is lacking. Of interest is the consideration of stop or go behaviors, such as not eating fast food or increasing the consumption of fruits and vegetables, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00330620183026
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http://dx.doi.org/10.1016/j.pcad.2018.12.008DOI Listing
March 2019
7 Reads

Precision Medicine in Weight Loss and Healthy Living.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):15-20. Epub 2019 Jan 3.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, United States of America; Integrated Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, IL, United States of America. Electronic address:

Obesity affects 600 million people globally and over one third of the American population. Along with associated comorbidities, including cardiovascular disease, stroke, diabetes, and cancer; the direct and indirect costs of managing obesity are 21% of the total medical costs. These factors shed light on why developing effective and pragmatic strategies to reduce body weight in obese individuals is a major public health concern. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00330620183026
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http://dx.doi.org/10.1016/j.pcad.2018.12.012DOI Listing
March 2019
9 Reads
2.418 Impact Factor

Precision Medicine, Healthy Living and the Complex Patient: Managing the Patient With Multimorbidity.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):29-33. Epub 2019 Jan 3.

Institute for Breathing and Sleep, Melbourne, Australia; Department of Physiotherapy, Monash University, Australia.

Multimorbidity is the most common chronic health condition in adults and is associated with poor health outcomes. Optimal care for people with multimorbidity requires a person-centred approach that considers goals and preferences, improves quality of life and coordinates care across services. Because care is focused on patient outcomes, rather than disease outcomes, this provides an ideal setting for delivery of the Healthy Living Polypill (HLPP). Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.010DOI Listing
March 2019
1 Read

Advances in Health Technology Use and Implementation in the Era of Healthy Living: Implications for Precision Medicine.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):44-49. Epub 2018 Dec 28.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; Department of Biomedical and Health Information Sciences, College of Applied Science, University of Illinois, Chicago, IL, USA.

Much of the focus of precision medicine has been directed toward genomics, despite the fact that "lifestyle and behavioral factors" are included in the description of precision medicine. Numerous structured diet and PA interventions have demonstrated success in preventing and/or reducing chronic-disease risk. The use of personal health technologies has expanded exponentially in the health care arena; there are a number of consumer-based technologies yielding health information to individual users. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.007DOI Listing
March 2019
2 Reads

Merging precision and healthy living medicine: Individualizing the path to a healthier lifestyle.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):1-2. Epub 2018 Dec 23.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.pcad.2018.12.006DOI Listing
March 2019
1 Read

The Contribution of Psychosocial Interventions to Precision Medicine for Heart Health.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):21-28. Epub 2018 Dec 18.

Department of Psychology, The University of Calgary, Calgary, Alberta, Canada. Electronic address:

This paper reviews the value of incorporating psychosocial interventions into precision medicine for heart health. First, we review the empirical literature on prevalence of common mental health comorbidities among individuals with cardiovascular disease (CVD). We then review transdiagnostic approaches for conceptualization and treatment of mental health in individuals with CVD. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.005DOI Listing
March 2019
2 Reads

Managing the Economic Challenges in the Treatment of Heart Failure.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):476-483. Epub 2018 Oct 25.

Stanford University School of Medicine, Stanford, CA, United States of America.

The economics of heart failure (HF) touches all patients with HF, their families, and the physicians and health systems that care for them. HF is specifically targeted by cost-reduction and care quality initiatives from the Centers for Medicare and Medicaid Services (CMS). The changing quality assessment and payment landscape is, and will continue to be, challenging for hospitals and HF specialists as they provide care for patients with this debilitating disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00330620183021
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http://dx.doi.org/10.1016/j.pcad.2018.10.002DOI Listing
January 2019
11 Reads

Addressing the Nutritional Phenotype Through Personalized Nutrition for Chronic Disease Prevention and Management.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):9-14. Epub 2018 Dec 13.

Internal Medicine-Obesity Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA, USA; Internal Medicine-Primary Care, San Mateo County Health System, San Mateo, CA, USA.

The primary focus of public health recommendations related to the prevention of food-related chronic disease has been on the adoption of healthy dietary patterns; however, implementation has been challenging. There has been increasing recognition that an individual's diet and environment may impact disease susceptibility by affecting the expression of genes involved in critical metabolic pathways. Precision nutrition (PN) has emerged to translate discoveries about diversity in nutrient metabolism between subgroups and the inter-individual variability in the responses to dietary interventions. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.004DOI Listing
March 2019
1 Read

The Association between the Change in Directly Measured Cardiorespiratory Fitness across Time and Mortality Risk.

Prog Cardiovasc Dis 2019 Mar - Apr;62(2):157-162. Epub 2018 Dec 10.

Ball State University, Muncie, IN, United States of America. Electronic address:

Background: The relationship between cardiorespiratory fitness (CRF) and mortality risk has typically been assessed using a single measurement, though some evidence suggests the change in CRF over time influences risk. This evidence is predominantly based on studies using estimated CRF (CRF). The strength of this relationship using change in directly measured CRF over time in apparently healthy men and women is not well understood. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.003DOI Listing
April 2019
1 Read

The Role of Government in Precision Medicine, Precision Public Health and the Intersection With Healthy Living.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):50-54. Epub 2018 Dec 7.

Institute for Precision Cardiovascular Medicine, American Heart Association, Dallas, TX, United States of America; Department of Medicine, University of Minnesota, Minneapolis, MN, United States of America; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.

This paper focuses on the significant role of government in promoting precision medicine and public health and the potential intersection with healthy living (HL) and population health. Recent research has highlighted the interplay between genes, environments and different exposures individuals and populations experience over a lifetime. These interactions between longitudinal behaviors, epigenetics, and expression of the human genome have the potential to transform health and well-being, even within a single generation. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.002DOI Listing
March 2019
4 Reads

Precision in Promoting Physical Activity and Exercise With the Overarching Goal of Moving More.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):3-8. Epub 2018 Dec 7.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.

Physical inactivity is strongly associated with an unfavorable health profile, increasing an individual's risk for developing cardiovascular disease. Initiating a regular exercise routine contributes to improvements in cardiorespiratory fitness, body composition, resting blood pressure, blood glucose, and circulating lipoproteins. However, the extent to which positive changes occur come with significant inter-individual variability within intervention groups; non-responders and responders have been commonly identified across populations, highlighting that not all exercise regimens are universally effective in all individuals and should therefore not be treated as a "one-size fits all" prescription. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.12.001DOI Listing
March 2019
2 Reads

Cardiorespiratory Fitness and Physical Activity: Two Important but Distinct Clinical Measures with Different Degrees of Precision - A Commentary.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):74-75. Epub 2018 Nov 24.

Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-University of Queensland School of Medicine, New Orleans, LA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00330620183022
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http://dx.doi.org/10.1016/j.pcad.2018.11.011DOI Listing
February 2019
3 Reads

Advances in Echocardiography.

Authors:
Carl J Lavie

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):389. Epub 2018 Nov 22.

Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - the University of Queensland School of Medicine, New Orleans, LA, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.pcad.2018.11.010DOI Listing
January 2019
20 Reads

Role of Transesophageal Echocardiography in Patients with Ischemic Stroke.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):456-467. Epub 2018 Nov 20.

John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA, United States of America.

Acute ischemic stroke is a condition with considerable mortality and morbidity. When used appropriately, Transesophageal Echocardiography (TEE) can be an incredibly useful tool to identify potential causes of stroke and guide management. The crucial distinction in this modality lies in separating common incidental findings from those likely to have contributed to ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.11.007DOI Listing
January 2019
14 Reads

Echocardiography in Transcatheter Structural Heart Disease Interventions.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):423-436. Epub 2018 Nov 20.

Division of Cardiology, University of California San Diego, San Diego, CA, United States of America. Electronic address:

Interventional echocardiography is an emerging field with growing interest and applications as therapeutic procedures to address structural heart disease (SHD) continue to evolve and expand. As opposed to coronary interventions, in which the course of catheter movement is constrained within the artery, percutaneous procedures for SHD entail free catheter movement within the heart and great vessels. Imaging guidance in 3-dimensional space is therefore of critical importance to the successful performance of these procedures. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.11.009DOI Listing
January 2019
9 Reads

Adult Congenital Heart Disease Care Provision: the Need for a Jack/Jackie of All Trades.

Prog Cardiovasc Dis 2018 Sep - Oct;61(3-4):273-274

Duke University Medical Center, Division of Cardiovascular Medicine, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.pcad.2018.09.001DOI Listing
December 2018
16 Reads

Doppler-Echocardiographic Assessment of Tricuspid Regurgitation.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):397-403. Epub 2018 Nov 14.

The Division of Cardiology, Mayo College of Medicine, Mayo Clinic, Rochester, MN, United States of America.

Compared with the vast literature concerning the echocardiographic assessment of mitral, or aortic disease, the data concerning the evaluation of tricuspid regurgitation (TR) is very limited. In this review we summarized the present data concerning the assessment of TR. We review the present knowledge concerning the pathogenesis of TR showing that it is extremely multi-factorial, thus, when assessing patients with TR by echocardiography it is imperative to focus on four major aspects: evaluation of severity of TR, assessment of the etiology of TR, evaluation of the mechanism of TR and suitability for surgical or per-cutaneous repair. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.11.008DOI Listing
January 2019
21 Reads

Echocardiography in Congenital Heart Disease.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):468-475. Epub 2018 Nov 13.

Department of Cardiovascular Disease, John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States of America. Electronic address:

As the prevalence of adult congenital heart disease continues to grow secondary to advances in surgical and diagnostic techniques, it is important for a physician to supplement their examinations with non-invasive imaging techniques to assess their patients. Although a number of these patients have regular cardiology followup, some may be new patients that do not even know their cardiac history. Echocardiography has proven to be a useful tool for this purpose and its utility has expanded drastically with the development of better technology and newer techniques. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.11.004DOI Listing
January 2019
18 Reads

Low-Gradient Aortic Stenosis: Solving the Conundrum Using Multi-Modality Imaging.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):416-422. Epub 2018 Nov 13.

Division of Cardiology, Mayo College of Medicine, Mayo Clinic, Rochester, MN, United States of America.

Up to 1/3 of patients with both reduced or preserved left ventricular ejection fraction (LVEF), harbor a mean pressure gradient (MPG) < 40 mm Hg (peak velocity (PV) < 4 m/s), suggesting moderate aortic stenosis (AS) and an aortic valve area (AVA) < 1 cm suggesting severe AS raising uncertainties regarding AS severity and appropriate management. In patients with reduced LVEF, increased transvalvular flow and stroke volume ≥ 20% (i.e. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.11.006DOI Listing
January 2019
25 Reads

An Update on the Role of Cardiorespiratory Fitness, Structured Exercise and Lifestyle Physical Activity in Preventing Cardiovascular Disease and Health Risk.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):484-490. Epub 2018 Nov 13.

Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.

The cardiovascular disease (CVD) pandemic has placed considerable strain on healthcare systems, quality of life, and physical function, while remaining the leading cause of death globally. Decades of scientific investigations have fortified the protective effects of cardiorespiratory fitness (CRF), exercise training, and physical activity (PA) against the development of CVD. This review will summarize recent efforts that have made significant strides in; 1) the application of novel analytic techniques to increase the predictive utility of CRF; 2) understanding the protective effects of long-term compliance to PA recommendations through large cohort studies with multiple points of assessment; 3) and understanding the potential harms associated with extreme volumes of PA. Read More

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January 2019
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Prognostic Implications of Left Ventricular Hypertrophy.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):446-455. Epub 2018 Nov 6.

John Ochsner Heart and Vascular Institute, Ochsner Clinical School- The University of Queensland School of Medicine, New Orleans, LA, United States of America.

Left ventricular hypertrophy (LVH) was one of the earliest studied echocardiographic characteristics of the left ventricle. As the myriad of measurable metrics has multiplied over recent years, this reliable and relevant variable can often be overlooked. In this paper, we discuss appropriate techniques for accurate analysis, underlying pathophysiology, and the contributions from various risk factors. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.11.002DOI Listing
January 2019
15 Reads

Is Speckle Tracking Imaging Ready for Prime Time in Current Echo Clinical Practice?

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):437-445. Epub 2018 Nov 5.

Division of Cardiovascular Ultrasound, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.

Accurate assessment of left and right ventricular systolic function plays a fundamental role in the prognostication and management of patients with known or suspected cardiovascular disease. Traditional echocardiographic parameters, including left ventricular ejection fraction, may lack the sensitivity to detect subclinical left ventricular systolic dysfunction. The advent of speckle tracking echocardiography for left and right ventricular systolic function assessment provides a further tool in this evaluation. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.11.001DOI Listing
January 2019
9 Reads

The Bicuspid Aortic Valve Condition: The Critical Role of Echocardiography and the Case for a Standard Nomenclature Consensus.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):404-415. Epub 2018 Nov 6.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

The bicuspid aortic valve (BAV) condition is characterized by prominent heterogeneity of its valvular phenotypic expression, of its associated disorders, its complications and its prognosis. Echocardiography serves as the first-line imaging modality in 5 major capacities: (1) BAV diagnosis, (2) valvular phenotyping, (3) assessment of valvular function, (4) measurement of the thoracic aorta and exclusion of aortic coarctation, and (5) assessment of uncommon but serious complications such as infective endocarditis and aortic dissection. This article presents a nosological perspective on the BAV condition, discusses the critical role of echocardiography as it relates to these 5 aforementioned capacities; and makes the case for a unified standard nomenclature for the BAV condition. Read More

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January 2019
27 Reads

Determining Cardiorespiratory Fitness With Precision: Compendium of Findings From the FRIEND Registry.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):76-82. Epub 2018 Oct 30.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, United States of America.

Healthy living (HL) behaviors and characteristics are central to both preventing and treating a myriad of chronic diseases; a key HL characteristic is cardiorespiratory fitness (CRF). Knowing an individual's CRF provides vital information when assessing health status and formulating a plan of care. Normative reference values as well as thresholds that denote varying degrees of health and future risk exist for measures of CRF. Read More

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March 2019
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Advanced Imaging Techniques for Mitral Regurgitation.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):390-396. Epub 2018 Oct 12.

Leon H. Charney Division of Cardiology, New York University Langone Health, 560 First Avenue, New York, NY 10016. Electronic address:

Mitral regurgitation (MR) is one of the most commonly encountered valvular lesions in clinical practice. MR can be either primary (degenerative) or secondary (functional) depending on the etiology of MR and the pathology of the mitral valve (MV). Echocardiography is the primary diagnostic tool for MR and is key in determining this etiology as well as MR severity. Read More

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January 2019
23 Reads

The Importance of School-based Healthy Living Initiatives: Introducing the Health and Wellness Academy Concept.

Prog Cardiovasc Dis 2019 Jan - Feb;62(1):68-73. Epub 2018 Sep 17.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.

Over the last 15 years, the number of school and community based health-intervention programs in the United States has grown. Many of these programs aim to prevent non-communicable chronic disease diagnoses (e.g. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.08.005DOI Listing
March 2019
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Long Term Consequences of the Fontan Procedure and How to Manage Them.

Prog Cardiovasc Dis 2018 Sep - Oct;61(3-4):365-376. Epub 2018 Sep 17.

Children's Hospital at Montefiore, Montefiore Medical Center, Albert Einstein College of Medicine, NY. Electronic address:

In 1971, Fontan and Baudet described a surgical technique for successful palliation of patients with tricuspid atresia. Subsequently, this technique has been applied to treat most forms of functional single ventricles and has become the current standard of care for long-term palliation of all patients with single ventricle congenital heart disease. Since 1971, the Fontan procedure has undergone several variations. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.09.005DOI Listing
December 2018
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Transcatheter Valve Replacement for Right-sided Valve Disease in Congenital Heart Patients.

Prog Cardiovasc Dis 2018 Sep - Oct;61(3-4):347-359. Epub 2018 Sep 17.

Division of Pediatric Cardiology, Department of Pediatrics, Duke University, Durham, NC; Address reprint requests to: Gregory A. Fleming, MD, Duke University Hospital, Division of Pediatric Cardiology, 2301 Erwin Rd, Box 3090, Durham, NC 27710. Electronic address:

Pulmonary and/or tricuspid valve dysfunction is common among individuals with congenital heart disease, and surgical intervention often carries prohibitive risks. Transcatheter valve replacement (TVR) of the right-sided cardiac valves has become a viable treatment option over the past two decades, while continued technological development aims to broaden its applicability to an even larger portion of those with repaired congenital heart disease. To date, two transcatheter valves have been approved for use in patients with dysfunctional right ventricular to pulmonary artery conduits as well as those with failing pulmonic bioprosthetic valves, and are also used off-label in the "native" RVOT and within surgically repaired/replaced but failing tricuspid valves. Read More

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http://dx.doi.org/10.1016/j.pcad.2018.09.003DOI Listing
December 2018
20 Reads