2,126 results match your criteria Progress in Neurobiology [Journal]


Angioneurins-key regulators of blood-brain barrier integrity during hypoxic and ischemic brain injury.

Prog Neurobiol 2019 Apr 7. Epub 2019 Apr 7.

Institute of Physiology and Pathophysiology, Heidelberg University, Germany.

The loss of blood-brain barrier (BBB) integrity leading to vasogenic edema and brain swelling is a common feature of hypoxic/ischemic brain diseases such as stroke, but is also central to the etiology of other CNS disorders. In the past decades, numerous proteins, belonging to the family of angioneurins, have gained increasing attention as potential therapeutic targets for ischemic stroke, but also other CNS diseases attributed to BBB dysfunction. Angioneurins encompass mediators that affect both neuronal and vascular function. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.03.004DOI Listing
April 2019
2 Reads

Microglia: brain cells on the move.

Prog Neurobiol 2019 Apr 4. Epub 2019 Apr 4.

UHasselt, BIOMED, Diepenbeek, Belgium. Electronic address:

In the last decade, tremendous progress has been made in understanding the biology of microglia - i.e. The fascinating immigrated resident immune cell population of the central nervous system (CNS). Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.04.001DOI Listing
April 2019
1 Read

Role and Mechanisms of Cytokines in the Secondary Brain Injury After Intracerebral Hemorrhage.

Prog Neurobiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. Electronic address:

Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic treatment for ICH and benefit poorly from this regimen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010082183014
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http://dx.doi.org/10.1016/j.pneurobio.2019.03.003DOI Listing
March 2019
2 Reads

Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior.

Prog Neurobiol 2019 Mar 21. Epub 2019 Mar 21.

Department of Zoology, Stockholm University, Stockholm, Sweden; Department of Neuroscience, Brown University, Providence, RI, USA. Electronic address:

This review focuses on neuropeptides and peptide hormones, the largest and most diverse class of neuroactive substances, known in Drosophila and other animals to play roles in almost all aspects of daily life, as well as in developmental processes. We provide an update on novel neuropeptides and receptors identified in the last decade, and highlight progress in analysis of neuropeptide signaling in Drosophila. Especially exciting is the huge amount of work published on novel functions of neuropeptides and peptide hormones in Drosophila, largely due to the rapid developments of powerful genetic methods, imaging techniques and innovative assays. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.02.003DOI Listing
March 2019
1 Read

Progress in neuromodulation of the brain: A role for magnetic nanoparticles?

Prog Neurobiol 2019 Mar 13. Epub 2019 Mar 13.

School for Mental Health and Neuroscience, Department of Neurosurgery, Maastricht University, Maastricht, 6200, MD, The Netherlands; European Graduate School of Neuroscience (EURON), The Netherlands; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, 6202, AZ, The Netherlands. Electronic address:

The field of neuromodulation is developing rapidly. Current techniques, however, are still limited as they i) either depend on permanent implants, ii) require invasive procedures, iii) are not cell-type specific, iv) involve slow pharmacokinetics or v) have a restricted penetration depth making it difficult to stimulate regions deep within the brain. Refinements into the different fields of neuromodulation are thus needed. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.03.002DOI Listing

Effects of estrogens and androgens on mitochondria under normal and pathological conditions.

Prog Neurobiol 2019 May 7;176:54-72. Epub 2019 Mar 7.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Several lines of evidence have suggested that mitochondrial dysfunction plays a key role in neurodegeneration. The mitochondrial function is a potential target for steroid hormones, which could exert protective activities in the brain and other tissues. The decrease of some sex steroids with aging has been associated with deleterious effects on brain function and progression to neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.03.001DOI Listing

Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review.

Prog Neurobiol 2019 Feb 17. Epub 2019 Feb 17.

Department Psychology and Brain Health Research Centre, University of Otago, Dunedin, New Zealand. Electronic address:

Many see the periaqueductal gray (PAG) as a region responsible for the downstream control of defensive reactions. Here we provide a detailed review of anatomical and functional data on the different parts of the PAG together with the dorsal raphe, which completes the circle of periaqueductal nuclei. Based on anatomical features, we propose a new subdivision of the periaqueductal gray that accounts for the distinct characteristics of the area. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.02.001DOI Listing
February 2019
1 Read

Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.

Prog Neurobiol 2019 Feb 13. Epub 2019 Feb 13.

Headache Science Center, IRCCS C. Mondino Foundation, Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Electronic address:

Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.02.002DOI Listing
February 2019
2 Reads

The roles of supervised machine learning in systems neuroscience.

Prog Neurobiol 2019 Apr 7;175:126-137. Epub 2019 Feb 7.

Department of Bioengineering, University of Pennsylvania, United States; Department of Neuroscience, University of Pennsylvania, United States; Canadian Institute for Advanced Research, Canada. Electronic address:

Over the last several years, the use of machine learning (ML) in neuroscience has been rapidly increasing. Here, we review ML's contributions, both realized and potential, across several areas of systems neuroscience. We describe four primary roles of ML within neuroscience: (1) creating solutions to engineering problems, (2) identifying predictive variables, (3) setting benchmarks for simple models of the brain, and (4) serving itself as a model for the brain. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.01.008DOI Listing

Sex differences in depression: Insights from clinical and preclinical studies.

Prog Neurobiol 2019 May 2;176:86-102. Epub 2019 Feb 2.

Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada; Department of Psychology, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Depression represents a global mental health concern, and disproportionally affects women as they are twice more likely to be diagnosed than men. In this review, we provide a summary of evidence to support the notion that differences in depression between men and women span multiple facets of the disease, including epidemiology, symptomology, treatment, and pathophysiology. Through a lens of biological sex, we overview depression-related transcriptional patterns, changes in neuroanatomy and neuroplasticity, and immune signatures. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.01.006DOI Listing
May 2019
1 Read

Action perception and motor imagery: Mental practice of action.

Prog Neurobiol 2019 Apr 31;175:107-125. Epub 2019 Jan 31.

Department of Basic Sciences, School of Medicine, University of Crete, Vassilika Vouton, 70013, Iraklion, Crete, Greece; Computational Neuroscience Group, Institute of Applied and Computational Mathematics, Foundation for Research and Technology-Hellas, Plastira N 100 str, 70013, Iraklion, Crete, Greece.

Motor cognition is related to the planning and generation of actions as well as to the recognition and imagination of motor acts. Recently, there is evidence that the motor system participates not only in overt actions but also in mental processes supporting covert actions. Within this framework, we have investigated the cortical areas engaged in execution, observation, and imagination of the same action, by the use of the high resolution quantitative C-deoxyglucose method in monkeys and by fMRI in humans, throughout the entire primate brain. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.01.007DOI Listing
April 2019
5 Reads

New windows into the brain: Central nervous system-derived extracellular vesicles in blood.

Prog Neurobiol 2019 Apr 25;175:96-106. Epub 2019 Jan 25.

Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA; Beijing Key Laboratory of Research and Transformation on Neurodegenerative Diseases Biomarkers, Department of Pathology, Peking University Third Hospital/Institute of Basic Science, Peking University Health Science Center, Beijing 100083, China. Electronic address:

Extracellular vesicles (EVs), including exosomes and (shedding) microvesicles, are released by nearly all cell types and carry a cargo of proteins and nucleic acids that varies by the cell of origin. They are thought to play critical roles in normal central nervous system (CNS) function and neurological disorders. A recently revealed key characteristic of EVs is that they may travel between the CNS and peripheral circulation. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.01.005DOI Listing
April 2019
3 Reads

Precision in the development of neocortical architecture: From progenitors to cortical networks.

Prog Neurobiol 2019 Apr 21;175:77-95. Epub 2019 Jan 21.

Department of Pediatrics and Program in Developmental Neuroscience and Developmental Neurogenetics, The Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, USA. Electronic address:

Of all brain regions, the 6-layered neocortex has undergone the most dramatic changes in size and complexity during mammalian brain evolution. These changes, occurring in the context of a conserved set of organizational features that emerge through stereotypical developmental processes, are considered responsible for the cognitive capacities and sensory specializations represented within the mammalian clade. The modern experimental era of developmental neurobiology, spanning 6 decades, has deciphered a number of mechanisms responsible for producing the diversity of cortical neuron types, their precise connectivity and the role of gene by environment interactions. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402587PMC
April 2019
4 Reads

The circuit architecture of cortical multisensory processing: Distinct functions jointly operating within a common anatomical network.

Prog Neurobiol 2019 Mar 21;174:1-15. Epub 2019 Jan 21.

Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098XH Amsterdam, the Netherlands; Research Priority Program Brain and Cognition, University of Amsterdam, Science Park 904, 1098XH Amsterdam, the Netherlands. Electronic address:

Our perceptual systems continuously process sensory inputs from different modalities and organize these streams of information such that our subjective representation of the outside world is a unified experience. By doing so, they also enable further cognitive processing and behavioral action. While cortical multisensory processing has been extensively investigated in terms of psychophysics and mesoscale neural correlates, an in depth understanding of the underlying circuit-level mechanisms is lacking. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.01.004DOI Listing
March 2019
8 Reads

Adult neurogenesis promotes balance recovery after vestibular loss.

Prog Neurobiol 2019 Mar 15;174:28-35. Epub 2019 Jan 15.

Aix Marseille Université-CNRS, Laboratoire de Neurosciences Sensorielles et Cognitives, LNSC UMR 7260, Equipe Physiopathologie et Thérapie des Désordres Vestibulaires, Marseille, France.

A phenomenon called vestibular compensation occurs after peripheral vestibular loss. This process involves a mosaic of profound structural rearrangements within the vestibular nuclei. Among them, adult reactive neurogenesis is perhaps the most unexpected, as it occurs in a brain area that was never reported as neurogenic before. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010082183014
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http://dx.doi.org/10.1016/j.pneurobio.2019.01.001DOI Listing
March 2019
17 Reads

Chronotherapies for Parkinson's disease.

Prog Neurobiol 2019 Mar 15;174:16-27. Epub 2019 Jan 15.

Movement Disorders Unit and Division of Sleep Medicine, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 600, Boston, MA, 02446, USA.

Parkinson's disease (PD) is the second-most common progressive neurodegenerative disorder. Although the clinical diagnosis of PD is still based on its cardinal motor dysfunctions, several non-motor symptoms (NMS) have been established as integral part of the disease. Unlike motor disorders, development of therapies against NMS are still challenging and remain a critical unmet clinical need. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377295PMC
March 2019
25 Reads

It's all about tau.

Prog Neurobiol 2019 Apr 31;175:54-76. Epub 2018 Dec 31.

Laboratory of Neurodegenerative Diseases, Centro de Investigación Biomédica, Universidad Autónoma de Chile, Santiago, Chile; Centro de Investigación y Estudio del Consumo de Alcohol en Adolescentes (CIIA), Santiago, Chile. Electronic address:

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to bind and stabilize microtubules. However, it is now becoming evident that the functions of tau extend beyond its ability to modulate microtubule dynamics. Tau plays a role in mediating axonal transport, synaptic structure and function, and neuronal signaling pathways. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397676PMC
April 2019
6 Reads

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies.

Prog Neurobiol 2019 Mar 30;174:53-89. Epub 2018 Dec 30.

Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India. Electronic address:

AD is a progressive neurodegenerative disorder and a leading cause of dementia in an aging population worldwide. The enormous challenge which AD possesses to global healthcare makes it as urgent as ever for the researchers to develop innovative treatment strategies to fight this disease. An in-depth analysis of the extensive available data associated with the AD is needed for a more comprehensive understanding of underlying molecular mechanisms and pathophysiological pathways associated with the onset and progression of the AD. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.12.006DOI Listing
March 2019
2 Reads

Transcriptional and epigenetic mechanisms underlying astrocyte identity.

Prog Neurobiol 2019 Mar 29;174:36-52. Epub 2018 Dec 29.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg. Electronic address:

Astrocytes play a significant role in coordinating neural development and provide critical support for the function of the CNS. They possess important adaptation capacities that range from their transition towards reactive astrocytes to their ability to undergo reprogramming, thereby revealing their potential to retain latent features of neural progenitor cells. We propose that the mechanisms underlying reactive astrogliosis or astrocyte reprogramming provide an opportunity for initiating neuronal regeneration, a process that is notably reduced in the mammalian nervous system throughout evolution. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.12.007DOI Listing
March 2019
1 Read

Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders.

Prog Neurobiol 2019 Apr 26;175:35-53. Epub 2018 Dec 26.

DPNC, University of Geneva, Geneva, Switzerland; CERN, Geneva, Switzerland. Electronic address:

Carnosine (β-alanyl-l-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Although discovered more than a hundred years ago and having been extensively studied in the periphery, the role of carnosine in the brain remains mysterious. Carnosinemia, a rare metabolic disorder with increased levels of carnosine in urine and low levels or absence of carnosinase in the blood, is associated with severe neurological symptoms in humans. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.12.004DOI Listing
April 2019
2 Reads

Lateral parietal cortex in the generation of behavior: Implications for apathy.

Prog Neurobiol 2019 Apr 24;175:20-34. Epub 2018 Dec 24.

NeuroImaging Center, University of Groningen, University Medical Center Groningen, the Netherlands; Department of Psychology, University of Groningen, the Netherlands.

A reduction in goal-directed behavior, or apathy, occurs in neurological and psychiatric disorders, though its neural substrates remain unclear. Deficits in circuits connecting the prefrontal cortex to subcortical regions are considered to underlie apathy. Although apathy is empirically associated with widespread changes in these regions, studies across disorders also link apathy with the lateral parietal cortex. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.12.003DOI Listing
April 2019
1 Read

Brain changes in a maternal immune activation model of neurodevelopmental brain disorders.

Prog Neurobiol 2019 Apr 24;175:1-19. Epub 2018 Dec 24.

University of Nebraska Medical Center, Neurological Sciences, 985960 Nebraska Medical Center, 68105, Omaha, NE, United States. Electronic address:

The developing brain is sensitive to a variety of insults. Epidemiological studies have identified prenatal exposure to infection as a risk factor for a range of neurological disorders, including autism spectrum disorder and schizophrenia. Animal models corroborate this association and have been used to probe the contribution of gene-environment interactions to the etiology of neurodevelopmental disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010082183000
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http://dx.doi.org/10.1016/j.pneurobio.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413503PMC
April 2019
18 Reads

Macrophage biology in the peripheral nervous system after injury.

Prog Neurobiol 2019 Feb 21;173:102-121. Epub 2018 Dec 21.

Department of Neurosciences, Case Western Reserve University, Cleveland, OH, 44106-4975, USA.

Neuroinflammation has positive and negative effects. This review focuses on the roles of macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of the distal nerve and to changes in the region of the axotomized cell bodies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010082183012
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http://dx.doi.org/10.1016/j.pneurobio.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340791PMC
February 2019
17 Reads

Axonal fusion: An alternative and efficient mechanism of nerve repair.

Prog Neurobiol 2019 Feb 27;173:88-101. Epub 2018 Nov 27.

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

Injuries to the nervous system can cause lifelong morbidity due to the disconnect that occurs between nerve cells and their cellular targets. Re-establishing these lost connections is the ultimate goal of endogenous regenerative mechanisms, as well as those induced by exogenous manipulations in a laboratory or clinical setting. Reconnection between severed neuronal fibers occurs spontaneously in some invertebrate species and can be induced in mammalian systems. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.11.004DOI Listing
February 2019
1 Read

Exercise as a therapeutic intervention for motor and non-motor symptoms in Parkinson's disease: Evidence from rodent models.

Prog Neurobiol 2019 Jan 24;172:2-22. Epub 2018 Nov 24.

Department of Anatomy and Neuroscience, University College Cork, Ireland; APC Microbiome Institute, University College Cork, Ireland. Electronic address:

Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons of the nigrostriatal pathway, which leads to the cardinal motor symptoms of the disease - tremor, rigidity and postural instability. A number of non-motor symptoms are also associated with PD, including cognitive impairment, mood disturbances and dysfunction of gastrointestinal and autonomic systems. Current therapies provide symptomatic relief but do not halt the disease process, so there is an urgent need for preventative strategies. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.11.003DOI Listing
January 2019
7 Reads

Welcome from the new Editor-in-Chief!

Authors:
Sabine Kastner

Prog Neurobiol 2019 Jan 23;172. Epub 2018 Nov 23.

Princeton University, United States.

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http://dx.doi.org/10.1016/j.pneurobio.2018.11.002DOI Listing
January 2019
1 Read

Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders.

Prog Neurobiol 2019 Jan 14;172:23-39. Epub 2018 Nov 14.

Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, United States. Electronic address:

Soluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the cytochrome P450 branch of the arachidonic acid pathway. EETs exert a variety of largely beneficial effects in the context of inflammation and vascular regulation. sEH inhibition is shown to be therapeutic in several cardiovascular and renal disorders, as well as in peripheral analgesia, via the increased availability of anti-inflammatory EETs. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.11.001DOI Listing
January 2019
31 Reads

Oxytocin receptor signaling in the hippocampus: Role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory.

Prog Neurobiol 2018 12 22;171:1-14. Epub 2018 Oct 22.

Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Beyond its well-known role in reproduction, the hypothalamic neuropeptide oxytocin (OXT) has been implicated in a broad spectrum of social and nonsocial behaviors. The biological actions of OXT are exerted through specific OXT receptors (OXTR) that belong to the family of G protein-coupled receptors. OXTR is abundantly expressed in the hippocampus, and the past decade has witnessed tremendous progress in our understanding of the physiological significance of hippocampal OXTR signaling. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.10.003DOI Listing
December 2018
2 Reads

Memory integration: An alternative to the consolidation/reconsolidation hypothesis.

Prog Neurobiol 2018 12 18;171:15-31. Epub 2018 Oct 18.

Department of Psychological Sciences, Kent State University, Kent, OH, 44242, USA.

The original concept of consolidation considers that memory requires time to be fixed. Since 2000, a comparable protein-dependent re-stabilization phase, called reconsolidation, has been assumed to take place after memory retrieval. This consolidation/reconsolidation hypothesis, has dominated the literature for more than 50 years, despite compelling evidence that is inconsistent with it. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010082173021
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http://dx.doi.org/10.1016/j.pneurobio.2018.10.002DOI Listing
December 2018
26 Reads

Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence.

Prog Neurobiol 2018 12 11;171:32-49. Epub 2018 Oct 11.

Department of Pharmacology and Experimental Therapeutics, University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, USA. Electronic address:

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric acid release are linked to chronic alcohol exposure. The effects of alcohol on the glutamatergic system in the mesocorticolimbic areas have been investigated extensively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010082183008
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http://dx.doi.org/10.1016/j.pneurobio.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261463PMC
December 2018
28 Reads
9.992 Impact Factor

Neural stem cell heterogeneity.

Prog Neurobiol 2018 11;170

Department of Cell & Systems Biology, University of Toronto, Ontario M5S 3G5, Canada.

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http://dx.doi.org/10.1016/j.pneurobio.2018.09.005DOI Listing
November 2018
1 Read

Caspases orchestrate microglia instrumental functions.

Prog Neurobiol 2018 12 2;171:50-71. Epub 2018 Oct 2.

Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. Electronic address:

Microglia, the resident immune cells of the brain, can acquire various cell phenotypes based on their location and current role. This level of plasticity is required to fulfil the vast variety of functions that microglia perform. Adequate microglial functions are crucial for a healthy brain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010082173016
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http://dx.doi.org/10.1016/j.pneurobio.2018.09.007DOI Listing
December 2018
6 Reads

Vesicular glutamate transporter isoforms: The essential players in the somatosensory systems.

Prog Neurobiol 2018 12 28;171:72-89. Epub 2018 Sep 28.

Department of Anatomy and K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:

In nervous system, glutamate transmission is crucial for centripetal conveyance and cortical perception of sensory signals of different modalities, which necessitates vesicular glutamate transporters 1-3 (VGLUT 1-3), the three homologous membrane-bound protein isoforms, to load glutamate into the presysnaptic vesicles. These VGLUTs, especially VGLUT1 and VGLUT2, selectively label and define functionally distinct neuronal subpopulations at each relay level of the neural hierarchies comprising spinal and trigeminal sensory systems. In this review, by scrutinizing each structure of the organism's fundamental hierarchies including dorsal root/trigeminal ganglia, spinal dorsal horn/trigeminal sensory nuclear complex, somatosensory thalamic nuclei and primary somatosensory cortex, we summarize and characterize in detail within each relay the neuronal clusters expressing distinct VGLUT protein/transcript isoforms, with respect to their regional distribution features (complementary distribution in some structures), axonal terminations/peripheral innervations and physiological functions. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.09.006DOI Listing
December 2018
1 Read
9.990 Impact Factor

Spatial representations in the primate hippocampus, and their functions in memory and navigation.

Prog Neurobiol 2018 12 13;171:90-113. Epub 2018 Sep 13.

Institut des Sciences Cognitives Marc Jeannerod, UMR 5229, CNRS, France; University of Lyon, Bron, France.

Hippocampal spatial view neurons in primates respond to the place where a monkey is looking, with some modulation by place. In contrast, hippocampal neurons in rodents respond mainly to the place where the animal is located. We relate this difference to the development of a fovea in primates, and the highly developed primate visual system which enables identification of what is at the fovea, and a system for moving the eyes to view different parts of the environment. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.09.004DOI Listing
December 2018
1 Read

New insights into the complex role of mitochondria in Parkinson's disease.

Prog Neurobiol 2018 Sep 13. Epub 2018 Sep 13.

Department of Neurogenetics, Kolling Institute of Medical Research, University of Sydney, Sydney, NSW, 2065, Australia; Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Department of Neurology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia. Electronic address:

New discoveries providing insights into mitochondrial bioenergetics, their dynamic interactions as well as their role in cellular homeostasis have dramatically advanced our understanding of the neurodegenerative process of Parkinson's disease (PD). Respiratory chain impairment is a key feature in sporadic PD patients and there is growing evidence that links proteins encoded by PD-associated genes to disturbances in mitochondrial function. Against the backdrop of latest advances in the development of PD treatments that target mitochondria, we aim to give an overview of the literature published in the last three decades on the significance of mitochondria in the pathogenesis of PD. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.09.003DOI Listing
September 2018
15 Reads

Neurobiological characteristics underlying metabolic differences between males and females.

Prog Neurobiol 2019 May 5;176:18-32. Epub 2018 Sep 5.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, Department of Pediatrics, Universidad Autónoma de Madrid, CIBEROBN (Centro de Investigación Biomédica en Red sobre Fisiopatología de la Obesidad y Nutrición), Instituto de Salud Carlos III. Madrid, Spain; IMDEA Food Institute, CEI UAM + CSIC, Madrid, Spain.

The hypothalamus is the main integrating center for metabolic control. Our understanding of how hypothalamic circuits function to control appetite and energy expenditure has increased dramatically in recent years, due to the rapid rise in the incidence of obesity and the search for effective treatments. Increasing evidence indicates that these treatments will most likely differ between males and females. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010082183008
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http://dx.doi.org/10.1016/j.pneurobio.2018.09.001DOI Listing
May 2019
19 Reads

Small cells with big implications: Microglia and sex differences in brain development, plasticity and behavioral health.

Prog Neurobiol 2019 May 5;176:103-119. Epub 2018 Sep 5.

Department of Psychology, The Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Brain sex differences are programmed largely by sex hormone secretions and direct sex chromosome effects in early life, and are subsequently modulated by early life experiences. The brain's resident immune cells, called microglia, actively contribute to brain development. Recent research has shown that microglia are sexually dimorphic, especially during early life, and may participate in sex-specific organization of the brain and behavior. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.09.002DOI Listing
May 2019
3 Reads

Non-cell-autonomous actions of α-synuclein: Implications in glial synucleinopathies.

Prog Neurobiol 2018 10 3;169:158-171. Epub 2018 Jul 3.

Department of Biomedical Sciences and Medicine, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address:

Many neurodegenerative diseases are derived from the combined consequences of genetic and environmental factors. One of the common features implicated in the neurodegenerative processes is aggregation of disease-specific neuronal proteins. These proteins are accumulated not only directly in neurons, but also indirectly involve glial cells. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.06.010DOI Listing
October 2018
2 Reads

A natural history of skills.

Prog Neurobiol 2018 12 29;171:114-124. Epub 2018 Aug 29.

University of Bordeaux, UMR 5293, IMN, 33000 Bordeaux, France; INRIA Bordeaux Sud-Ouest, 33405 Talence, France; LaBRI, University of Bordeaux, IPB, CNRS, UMR 5800, 33405 Talence, France.

The dorsal pallium (a.k.a. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.08.003DOI Listing
December 2018
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Elucidating sex differences in response to cerebral ischemia: immunoregulatory mechanisms and the role of microRNAs.

Prog Neurobiol 2019 May 16;176:73-85. Epub 2018 Aug 16.

Stanford University School of Medicine, Department of Anesthesiology, Perioperative & Pain Medicine, United States. Electronic address:

Cerebral ischemia remains a major cause of death and disability worldwide, yet therapeutic options remain limited. Differences in sex and age play an important role in the final outcome in response to cerebral ischemia in both experimental and clinical studies: males have a higher risk and worse outcome than females at younger ages and this trend reverses in older ages. Although the molecular mechanisms underlying sex dimorphism are complex and are still not well understood, studies suggest steroid hormones, sex chromosomes, differential cell death and immune pathways, and sex-specific microRNAs may contribute to the outcome following cerebral ischemia. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.08.001DOI Listing
May 2019
19 Reads

The role of T cells in the pathogenesis of Parkinson's disease.

Prog Neurobiol 2018 10 13;169:1-23. Epub 2018 Aug 13.

Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Recent evidence has shown that neuroinflammation plays a key role in the pathogenesis of Parkinson's disease (PD). However, different components of the brain's immune system may exert diverse effects on neuroinflammatory events in PD. The adaptive immune response, especially the T cell response, can trigger type 1 pro-inflammatory activities and suppress type 2 anti-inflammatory activities, eventually resulting in deregulated neuroinflammation and subsequent dopaminergic neurodegeneration. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.08.002DOI Listing
October 2018
10 Reads
9.990 Impact Factor

Regeneration of peripheral nerves by nerve guidance conduits: Influence of design, biopolymers, cells, growth factors, and physical stimuli.

Prog Neurobiol 2018 12 2;171:125-150. Epub 2018 Aug 2.

Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada; Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada. Electronic address:

Injuries to the peripheral nervous system (PNS) cause neuropathies that lead to weakness and paralysis, poor or absent sensation, unpleasant and painful neuropathies, and impaired autonomic function. In this regard, implanted artificial nerve guidance conduits (NGCs) used to bridge an injured site may provide appropriate biochemical and biophysical guidance cues required to stimulate regeneration across a nerve gap and restore the function of PNS. Advanced conduit design and fabrication techniques have made it possible to fabricate autograft-like structures in the NGCs with incredible precision. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.07.002DOI Listing
December 2018
2 Reads

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner.

Authors:
Isidro Ferrer

Prog Neurobiol 2018 10 2;169:24-54. Epub 2018 Aug 2.

Department of Pathology and Experimental Therapeutics, University of Barcelona, Hospitalet de Llobregat, Spain; Service of Pathology, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat, Spain; CIBERNED (Biomedical Network Research Centre of Neurodegenerative Diseases), Institute of Health Carlos III, Spain; Institute of Neurosciences, University of Barcelona, Spain. Electronic address:

Oligodendrocytes are in contact with neurons, wrap axons with a myelin sheath that protects their structural integrity, and facilitate nerve conduction. Oligodendrocytes also form a syncytium with astrocytes which interacts with neurons, promoting reciprocal survival mediated by activity and by molecules involved in energy metabolism and trophism. Therefore, oligodendrocytes are key elements in the normal functioning of the central nervous system. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.07.004DOI Listing
October 2018
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Selective basal ganglia vulnerability to energy deprivation: Experimental and clinical evidences.

Prog Neurobiol 2018 10 2;169:55-75. Epub 2018 Aug 2.

Neurology Clinic, Movement Disorders Center, University of Perugia - S. Maria della Misericordia Hospital, Piazzale Menghini 1, Sant'Andrea delle Fratte, Perugia, 06132, Italy; IRCCS Fondazione "S. Lucia", Rome, Italy. Electronic address:

The basal ganglia (BG) include structures pivotal for motor and cognitive functions. Such structures are affected in neurodegenerative disorders and toxic or ischemic insults. The peculiar vulnerability of BG to toxic and ischemic damage has been the focus of preclinical research for all over the last century. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.07.003DOI Listing
October 2018
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System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders.

Prog Neurobiol 2018 10 27;169:76-90. Epub 2018 Jul 27.

Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

The surge in meals high in calories has prompted an epidemic of metabolic disorders around the world such that the elevated incidence of obese and diabetic individuals is alarming. New research indicates that metabolic disorders pose a risk for neurological and psychiatric conditions including stroke, Alzheimer's disease, Huntington's disease, and depression, all of which have a metabolic component. These relationships are rooted to a dysfunctional interaction between molecular processes that regulate energy metabolism and synaptic plasticity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231047PMC
October 2018
3 Reads

The sinister face of heme oxygenase-1 in brain aging and disease.

Prog Neurobiol 2019 Jan 29;172:40-70. Epub 2018 Jul 29.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Department of Neurology and Neurosurgery McGill University, Montreal, Quebec, Canada.

Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1). A wide range of pro-oxidant and inflammatory stimuli act on diverse consensus sequences within the Hmox1 promoter to rapidly induce the gene. There is ample evidence attesting to the beneficial effects of HO-1 upregulation in brain. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.06.008DOI Listing
January 2019
49 Reads

Exosomes and their implications in central nervous system tumor biology.

Prog Neurobiol 2019 Jan 9;172:71-83. Epub 2018 Jul 9.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States. Electronic address:

Exosomes are 20-100 nm cellular derived vesicles that upon discovery, were thought to be a form of cellular recycling of intracellular contents. More recently, these vesicles are under investigation for their purported significant roles in intercellular communication in both healthy and diseased states. Herein, we focus on the secretion of exosomes associated with glioblastoma, as most exosome studies on brain tumors have been performed in this tumor type. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.06.006DOI Listing
January 2019
70 Reads

Thinking about the nerve impulse: A critical analysis of the electricity-centered conception of nerve excitability.

Prog Neurobiol 2018 10 4;169:172-185. Epub 2018 Jul 4.

Department of Philosophy, Faculty of Humanities, VU University Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands.

Nerve impulse generation and propagation are often thought of as solely electrical events. The prevalence of this view is the result of long and intense study of nerve impulses in electrophysiology culminating in the introduction of the Hodgkin-Huxley model of the action potential in the 1950s. To this day, this model forms the physiological foundation for a broad area of neuroscientific research. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.06.009DOI Listing
October 2018
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The histology, physiology, neurochemistry and circuitry of the substantia gelatinosa Rolandi (lamina II) in mammalian spinal cord.

Prog Neurobiol 2018 10 4;169:91-134. Epub 2018 Jul 4.

Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, I-10095 Grugliasco (TO), Italy. Electronic address:

The substantia gelatinosa Rolandi (SGR) was first described about two centuries ago. In the following decades an enormous amount of information has permitted us to understand - at least in part - its role in the initial processing of pain and itch. Here, I will first provide a comprehensive picture of the histology, physiology, and neurochemistry of the normal SGR. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.06.012DOI Listing
October 2018
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Insights into the pharmaceuticals and mechanisms of neurological orphan diseases: Current Status and future expectations.

Prog Neurobiol 2018 10 4;169:135-157. Epub 2018 Jul 4.

Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic. Electronic address:

Several rare or orphan diseases have been characterized that singly affect low numbers of people, but cumulatively reach ∼6%-10% of the population in Europe and in the United States. Human genetics has shown to be broadly effective when evaluating subjacent genetic defects such as orphan genetic diseases, but on the other hand, a modest progress has been achieved toward comprehending the molecular pathologies and designing new therapies. Chemical genetics, placed at the interface of chemistry and genetics, could be employed to understand the molecular mechanisms of subjacent illnesses and for the discovery of new remediation processes. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2018.06.011DOI Listing
October 2018
6 Reads