911 results match your criteria Progress in Lipid Research [Journal]


Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease.

Prog Lipid Res 2019 Apr 8;74:186-195. Epub 2019 Apr 8.

Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, VIC 3800, Australia. Electronic address:

Plasmalogens are a class of membrane glycerophospholipids with unique properties. They contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and, typically, a polyunsaturated fatty acyl chain at the sn-2 position. Plasmalogens are critical for human health and have established roles in neuronal development, the immune response and as endogenous antioxidants. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.04.003DOI Listing

Ceramide synthases in cancer therapy and chemoresistance.

Prog Lipid Res 2019 Apr 4;74:160-185. Epub 2019 Apr 4.

Institute of Clinical Pharmacology, Faculty of Medicine, Goethe University Frankfurt, Theodor-Stern Kai 7, Frankfurt 60590, Germany. Electronic address:

Drug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated by CerS and the respective ceramides of specific chain length contributing to chemoresistance and how we can interfere with these mechanisms to overcome drug resistance by targeting CerS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01637827193001
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http://dx.doi.org/10.1016/j.plipres.2019.04.002DOI Listing
April 2019
5 Reads

Ceramide and sphingosine 1-phosphate in adipose dysfunction.

Prog Lipid Res 2019 Apr 2;74:145-159. Epub 2019 Apr 2.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, United Kingdom. Electronic address:

The increased adipose tissue mass of obese individuals enhances the risk of metabolic syndrome, type 2 diabetes and cardiovascular diseases. During pathological expansion of adipose tissue, multiple molecular controls of lipid storage, adipocyte turn-over and endocrine secretion are perturbed and abnormal lipid metabolism results in a distinct lipid profile. There is a role for ceramides and sphingosine 1-phosphate (S1P) in inducing adipose dysfunction. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.04.001DOI Listing
April 2019
5 Reads

Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain.

Prog Lipid Res 2019 Mar 12;74:130-144. Epub 2019 Mar 12.

Department of Human Genetics, McGill University, Montreal, QC, Canada; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, QC, Canada. Electronic address:

Ceramides, the principal building blocks of all sphingolipids, have attracted the attention of many scientists around the world interested in developing treatments for cystic fibrosis, the most common genetic disease of Caucasians. Many years of fruitful research in this field have produced some fundamentally important, yet controversial results. Here, we aimed to summarize the current knowledge on the role of long- and very-long- chain ceramides, the most abundant species of ceramides in animal cells, in cystic fibrosis and other diseases. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.03.001DOI Listing
March 2019
9 Reads

Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?"

Prog Lipid Res 2019 Feb 26;74:87-102. Epub 2019 Feb 26.

Department of Nutrition and Movement Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands.

Dietary plant sterols and stanols as present in our diet and in functional foods are well-known for their inhibitory effects on intestinal cholesterol absorption, which translates into lower low-density lipoprotein cholesterol concentrations. However, emerging evidence suggests that plant sterols and stanols have numerous additional health effects, which are largely unnoticed in the current scientific literature. Therefore, in this review we pose the intriguing question "What would have occurred if plant sterols and stanols had been discovered and embraced by disciplines such as immunology, hepatology, pulmonology or gastroenterology before being positioned as cholesterol-lowering molecules?" What would then have been the main benefits and fields of application of plant sterols and stanols today? We here discuss potential effects ranging from its presence and function intrauterine and in breast milk towards a potential role in the development of non-alcoholic steatohepatitis (NASH), cardiovascular disease (CVD), inflammatory bowel diseases (IBD) and allergic asthma. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.02.003DOI Listing
February 2019
2 Reads

Metabolic engineering for enhanced oil in biomass.

Prog Lipid Res 2019 Feb 26;74:103-129. Epub 2019 Feb 26.

CSIRO Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT, Australia.

The world is hungry for energy. Plant oils in the form of triacylglycerol (TAG) are one of the most reduced storage forms of carbon found in nature and hence represent an excellent source of energy. The myriad of applications for plant oils range across foods, feeds, biofuels, and chemical feedstocks as a unique substitute for petroleum derivatives. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.02.002DOI Listing
February 2019
10.015 Impact Factor

Human milk fat substitutes: Past achievements and current trends.

Prog Lipid Res 2019 Feb 20;74:69-86. Epub 2019 Feb 20.

State Key Lab of Food Science and Technology, Jiangnan University, Wuxi 214122, China; International Joint Research Laboratory for Lipid Nutrition and Safety, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address:

The first commercial infant formula, invented in 1867, contained lipids mainly from cow's milk. We now know that human milk fat differs from the milk fat of other mammals and even more from vegetable oils. Human milk fat is one of the most complex natural lipid mixtures with a unique fatty acid composition, distribution, and numerous complex lipids. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.02.001DOI Listing
February 2019
1 Read

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.

Prog Lipid Res 2019 Jan 30;74:18-30. Epub 2019 Jan 30.

Biological Research Centre, Hungarian Academy of Sciences, Institute of Biochemistry, Szeged, Hungary. Electronic address:

Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates endocytosis, counteracts apoptotic mechanisms, sustains survival pathways or represents a signal that can be recognized by the immune system. Disease-coupled lipid-associated functions of Hsp70 may be targeted via distinct subcellular localizations of Hsp70 itself or its specific interacting lipids. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.01.004DOI Listing
January 2019

The lipid biochemistry of eukaryotic algae.

Prog Lipid Res 2019 Jan 28;74:31-68. Epub 2019 Jan 28.

School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK. Electronic address:

Algal lipid metabolism fascinates both scientists and entrepreneurs due to the large diversity of fatty acyl structures that algae produce. Algae have therefore long been studied as sources of genes for novel fatty acids; and, due to their superior biomass productivity, algae are also considered a potential feedstock for biofuels. However, a major issue in a commercially viable "algal oil-to-biofuel" industry is the high production cost, because most algal species only produce large amounts of oils after being exposed to stress conditions. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.01.003DOI Listing
January 2019
9 Reads

Phytol metabolism in plants.

Prog Lipid Res 2019 Jan 7;74:1-17. Epub 2019 Jan 7.

Institute of Molecular Physiology and Biotechnology of Plants (IMBIO), University of Bonn, Karlrobert-Kreiten-Strasse 13, 53115 Bonn, Germany. Electronic address:

Phytol, the prenyl side chain of chlorophyll, is derived from geranylgeraniol by reduction of three double bonds. Recent results demonstrated that the conversion of geranylgeraniol to phytol is linked to chlorophyll synthesis, which is catalyzed by protein complexes associated with the thylakoid membranes. One of these complexes contains light harvesting chlorophyll binding like proteins (LIL3), enzymes of chlorophyll synthesis (protoporphyrinogen oxidoreductase, POR; chlorophyll synthase, CHLG) and geranylgeranyl reductase (GGR). Read More

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http://dx.doi.org/10.1016/j.plipres.2019.01.002DOI Listing
January 2019
6 Reads

Biochemical studies of membrane fusion at the single-particle level.

Prog Lipid Res 2019 01 3;73:92-100. Epub 2019 Jan 3.

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

To study membrane fusion mediated by synaptic proteins, proteoliposomes have been widely used for in vitro ensemble measurements with limited insights into the fusion mechanism. Single-particle techniques have proven to be powerful in overcoming the limitations of traditional ensemble methods. Here, we summarize current single-particle methods in biophysical and biochemical studies of fusion mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and other synaptic proteins, together with their advantages and limitations. Read More

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http://dx.doi.org/10.1016/j.plipres.2019.01.001DOI Listing
January 2019
1 Read

Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis.

Prog Lipid Res 2019 01 4;73:65-91. Epub 2018 Dec 4.

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Medical Research Experiment Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China. Electronic address:

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is removed by the reverse cholesterol transport (RCT) pathway, representing a major antiatherogenic mechanism. In addition to the RCT, other pathways are required for maintaining the whole-body cholesterol homeostasis. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.12.002DOI Listing
January 2019
3 Reads

Enzymes of glycerol-3-phosphate pathway in triacylglycerol synthesis in plants: Function, biotechnological application and evolution.

Prog Lipid Res 2019 01 4;73:46-64. Epub 2018 Dec 4.

Programa de Pós-Graduação em Genética e Biologia Molecular, Departmento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil.. Electronic address:

Triacylglycerols (TAG) are the major form of energy storage in plants. TAG are primarily stored in seeds and fruits, but vegetative tissues also possess a high capacity for their synthesis and storage. These storage lipids are essential to plant development, being used in seedling growth during germination, pollen development, and sexual reproduction, for example. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.12.001DOI Listing
January 2019
11 Reads

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies.

Prog Lipid Res 2019 01 22;73:28-45. Epub 2018 Nov 22.

Department of Physiology, University of Tennessee Health Science Center, 71 S. Manassas Street Memphis, Memphis, TN 38163, USA. Electronic address:

12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338518PMC
January 2019
1 Read

Plant lipids: Key players of plasma membrane organization and function.

Prog Lipid Res 2019 01 19;73:1-27. Epub 2018 Nov 19.

Laboratoire de Biogenèse Membranaire (LBM), CNRS, University of Bordeaux, UMR 5200, F-33882 Villenave d'Ornon, France. Electronic address:

The plasma membrane (PM) is the biological membrane that separates the interior of all cells from the outside. The PM is constituted of a huge diversity of proteins and lipids. In this review, we will update the diversity of molecular species of lipids found in plant PM. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.11.002DOI Listing
January 2019
16 Reads

The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs.

Prog Lipid Res 2018 10 17;72:55-74. Epub 2018 Sep 17.

Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Biochemistry, Charitéplatz 1, CCO- Building, Virchowweg 6, D-10117 Berlin, Germany.

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http://dx.doi.org/10.1016/j.plipres.2018.09.002DOI Listing
October 2018
2 Reads

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology.

Prog Lipid Res 2018 10 6;72:42-54. Epub 2018 Sep 6.

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; Ophthalmology, Department of Surgery, the University of Melbourne, Melbourne, Australia. Electronic address:

Stem cells are unique in their ability to self-renew and differentiate into various cell types. Because of these features, stem cells are key to the formation of organisms and play fundamental roles in tissue regeneration and repair. Mechanisms controlling their fate are thus fundamental to the development and homeostasis of tissues and organs. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.09.001DOI Listing
October 2018
1 Read

Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction.

Prog Lipid Res 2018 10 25;72:18-41. Epub 2018 Aug 25.

Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Sulfogalactosylglycerolipid (SGG, aka seminolipid) is selectively synthesized in high amounts in mammalian testicular germ cells (TGCs). SGG is an ordered lipid and directly involved in cell adhesion. SGG is indispensable for spermatogenesis, a process that greatly depends on interaction between Sertoli cells and TGCs. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239905PMC
October 2018
24 Reads

Lipid storage myopathies: Current treatments and future directions.

Prog Lipid Res 2018 10 9;72:1-17. Epub 2018 Aug 9.

Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Westmead, NSW, Australia.; Discipline of Paediatrics & Child Heath, Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia. Electronic address:

Lipid storage myopathies (LSMs) are a heterogeneous group of genetic disorders that present with abnormal lipid storage in multiple body organs, typically muscle. Patients can clinically present with cardiomyopathy, skeletal muscle weakness, myalgia, and extreme fatigue. An early diagnosis is crucial, as some LSMs can be managed by simple nutraceutical supplementation. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.08.001DOI Listing
October 2018
26 Reads

Innovations in improving lipid production: Algal chemical genetics.

Prog Lipid Res 2018 07 12;71:101-123. Epub 2018 Jul 12.

Department of Biochemistry, University of Nebraska-Lincoln, Beadle Center, 1901 Vine St., Lincoln, NE 68588-0664, USA.

Perturbation of a biological system with small molecules to achieve a desired phenotype or activity is commonly referred as chemical genetics. In pharmaceutical discovery, this approach is most often employed in target-based screening but in plants systems the focus is primarily on phenotypic selection for commercially relevant phenotype generation such as crop improvement or disease and pathogen resistance. Likewise, algae are considered feedstock organisms for viable and sustainable biofuels and other high value products with commercial applications. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.07.001DOI Listing
July 2018
21 Reads
10.015 Impact Factor

Contemporary lipidomic analytics: opportunities and pitfalls.

Prog Lipid Res 2018 07 27;71:86-100. Epub 2018 Jun 27.

Curtin Health Innovation Research Institute, Curtin University, WA, Australia; School of Public Health, Faculty of Health Sciences, Curtin University, WA, Australia. Electronic address:

Recent advances in analytical techniques have greatly enhanced the depth of coverage, however lipidomic studies are still restricted to analysing only a subset of known lipids. Numerous complementary techniques are used for investigation of cellular lipidomes, including mass spectrometry (MS), nuclear magnetic resonance and vibrational spectroscopy. The development in electrospray ionization (ESI) MS has accelerated lipidomics research in the past two decades and represents one of the most widely used technique. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.06.003DOI Listing
July 2018
1 Read

Milk lipidomics: What we know and what we don't.

Prog Lipid Res 2018 07 20;71:70-85. Epub 2018 Jun 20.

Agriculture Victoria Research, AgriBio, Centre for AgriBioscience, Bundoora, Victoria 3083, Australia; School of Applied Systems Biology, La Trobe University, Bundoora, Victoria 3083, Australia.

Bovine milk contains 3-5% of fat, of which the dominant portion (about 98%) is in the form of triacylglycerols, whereas polar lipids such as glycerophospholipids and sphingolipids are minor components (0.5-1%) of milk fat. Milk fat is thought to contain several thousand lipid species, making it the most complex material in nature in terms of lipid composition. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.06.002DOI Listing
July 2018
18 Reads

High density lipoprotein cholesterol and cancer: Marker or causative?

Prog Lipid Res 2018 07 4;71:54-69. Epub 2018 Jun 4.

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address:

The relationship between high-density lipoproteins (HDLs), HDL-cholesterol (HDLC) and cancer incidence and mortality is controversial. Although most studies conducted so far, including well-designed prospective studies and meta-analyses, have revealed a significant inverse association between HDL-C levels and cancer risk, several confounding factors and opposite results showing either a direct or an inverse association between HDL-C levels and cancer mortality have hindered the possibility to derive definitive conclusions. Moreover, different lines of research also pointed out that this association might actually reflect an inverse causality, which would imply that low HDL-C levels merely represent an epiphenomenon of cancer-related inflammation and cancer cell renewal. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.06.001DOI Listing
July 2018
15 Reads

The phosphatidic acid paradox: Too many actions for one molecule class? Lessons from plants.

Prog Lipid Res 2018 07 26;71:43-53. Epub 2018 May 26.

Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine; CNRS, UMR7618, Institut d'Ecologie et des Sciences de l'Environnement de Paris, Créteil, France. Electronic address:

Phosphatidic acid (PA) is a simple phospholipid observed in most organisms. PA acts as a key metabolic intermediate and a second messenger that regulates many cell activities. In plants, PA is involved in numerous cell responses induced by hormones, stress inputs and developmental processes. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.05.003DOI Listing
July 2018
4 Reads

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain.

Prog Lipid Res 2018 07 8;71:1-17. Epub 2018 May 8.

Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.. Electronic address:

2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.05.002DOI Listing
July 2018
1 Read

Sphingolipid hydroxylation in mammals, yeast and plants - An integrated view.

Prog Lipid Res 2018 07 8;71:18-42. Epub 2018 May 8.

Centro de Química e Bioquímica, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Ed. C8, Campo Grande, 1749-016 Lisboa, Portugal. Electronic address:

This review is focused on sphingolipid backbone hydroxylation, a small but widespread structural feature with profound impact on membrane biophysical properties. We start by summarizing sphingolipid metabolism in mammalian cells, yeast and plants, focusing on how distinct hydroxylation patterns emerge in different eukaryotic kingdoms. Then, a comparison of the biophysical properties in membrane model systems and cellular membranes from diverse organisms is made. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.05.001DOI Listing
July 2018
1 Read

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health.

Prog Lipid Res 2018 04 19;70:62-93. Epub 2018 Apr 19.

Department of Plant Production and Forestry Science, Universitat de Lleida-Agrotecnio, 25198 Lleida, Spain.

Carotenoids are lipophilic isoprenoid compounds synthesized by all photosynthetic organisms and some non-photosynthetic prokaryotes and fungi. With some notable exceptions, animals (including humans) do not produce carotenoids de novo but take them in their diets. In photosynthetic systems carotenoids are essential for photoprotection against excess light and contribute to light harvesting, but perhaps they are best known for their properties as natural pigments in the yellow to red range. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.04.004DOI Listing
April 2018
4 Reads

Fat nucleosome: Role of lipids on chromatin.

Prog Lipid Res 2018 04 17;70:29-34. Epub 2018 Apr 17.

Laboratório de Farmacologia Molecular, Departamento de Farmácia, Universidade de Brasília, Brasília 70919-970, Brazil. Electronic address:

Structural changes in chromatin regulate gene expression and define phenotypic outcomes. Molecules that bind to the nucleosome, the complex of DNA and histone proteins, are key modulators of chromatin structure. Most recently, the formation of condensed chromatin regions based on phase-separation in the cell, a basic physical mechanism, was proposed. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.04.003DOI Listing
April 2018
3 Reads

STAT3: The art of multi-tasking of metabolic and immune functions in obesity.

Prog Lipid Res 2018 04 7;70:17-28. Epub 2018 Apr 7.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China. Electronic address:

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that has recently attracted increased attention. Accumulating studies have demonstrated that STAT3 plays an important role in various diseases, such as cancer and ischemic injury. In light of the distinctive effects of STAT3 on the regulation of metabolism and immune responses, we present the elaborate network of STAT3 in obesity. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.04.002DOI Listing
April 2018
6 Reads

Phytosterols and their derivatives: Structural diversity, distribution, metabolism, analysis, and health-promoting uses.

Prog Lipid Res 2018 04 5;70:35-61. Epub 2018 Apr 5.

Sustainable Biofuels and Coproducts Research Unit, Eastern Regional Research Center, United States Department of Agriculture, Agricultural Research Service, 600 East Mermaid Lane, Wyndmoor, PA 18951, USA.

Phytosterols (plant sterols) occur in the cells of all plants. They are important structural components that stabilize the biological membranes of plants. Sterols can occur in the "free" unbound form or they can be covalently bound via an ester or glycosidic bond. Read More

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http://dx.doi.org/10.1016/j.plipres.2018.04.001DOI Listing
April 2018
8 Reads

Current trends to comprehend lipid metabolism in diatoms.

Prog Lipid Res 2018 04 7;70:1-16. Epub 2018 Mar 7.

University of Goettingen, Albrecht-von-Haller-Institute for Plant Sciences, Department of Plant Biochemistry, 37077 Goettingen, Germany; University of Goettingen, Goettingen Center for Molecular Biosciences (GZMB), Department of Plant Biochemistry, 37077 Goettingen, Germany. Electronic address:

Diatoms are the most dominant phytoplankton species in oceans and they continue to receive a great deal of attention because of their significant contributions in ecosystems and the environment. Due to triacylglycerol (TAG) profiles that are abundant in medium-chain fatty acids, diatoms have emerged to be better feed stocks for biofuel production, in comparison to the commonly studied green microalgal species (chlorophytes). Importantly, diatoms are also known for their high levels of the essential ω3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and are considered to be a promising alternative source of these components. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01637827173006
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http://dx.doi.org/10.1016/j.plipres.2018.03.001DOI Listing
April 2018
8 Reads

Determinants of cholesterol efflux capacity in humans.

Prog Lipid Res 2018 01 18;69:21-32. Epub 2017 Dec 18.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands. Electronic address:

High-density lipoproteins (HDL) play an important role in the reverse cholesterol transport (RCT) pathway, contributing to the efflux of excess cellular cholesterol. However, the classic hypothesis that raising HDL-cholesterol (HDL-C) concentrations reduces cardiovascular disease (CVD) risk has been challenged by recent intervention studies. Nowadays, improving cholesterol efflux capacity of HDL particles is considered to be a better target for the prevention of CVD. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.12.001DOI Listing
January 2018
10 Reads

Adipocyte biology in breast cancer: From silent bystander to active facilitator.

Prog Lipid Res 2018 01 21;69:11-20. Epub 2017 Nov 21.

Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

Adipocytes account for the largest proportion among the cells that comprise breast tissue; therefore, they are considered to be a critical cell type in the tumor microenvironment of breast cancer. In breast cancer, adipocytes are not only found adjacent to cancer cells, but they also play an active role in the entire process of cancer development, progression, metastasis, and treatment response. Factors including the secretion of adipokines such as leptin and adiponectin, as well as autotaxin, interleukin 6, tumor necrosis factor alpha, and hepatic growth factor, metabolic remodeling that supports the growth of breast cancer by transfer of fatty acids to increase mitochondrial β-oxidation, extracellular matrix remodeling and endotrophin production from type IV collagen, and cancer-associated fibroblast phenotype changes have all been implicated in this comprehensive process. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.11.002DOI Listing
January 2018
4 Reads

Exploring the functional significance of sterol glycosyltransferase enzymes.

Prog Lipid Res 2018 01 21;69:1-10. Epub 2017 Nov 21.

CSIR-National Botanical Research Institute, Lucknow 226001, India. Electronic address:

Steroidal alkaloids (SAs) are widely synthesized and distributed in plants manifesting as natural produce endowed with potential for medicinal, pesticidal and other high-value usages. Glycosylation of these SAs raises complex and diverse glycosides in plant cells that indeed govern numerous functional aspects. During the glycosylation process of these valuable metabolites, the addition of carbohydrate molecule(s) is catalyzed by enzymes known as sterol glycosyltransferases (SGTs), commonly referred to as UGTs, leading to the production of steryl glycosides (SGs). Read More

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http://dx.doi.org/10.1016/j.plipres.2017.11.001DOI Listing
January 2018
3 Reads

Furan fatty acids - Beneficial or harmful to health?

Prog Lipid Res 2017 10 16;68:119-137. Epub 2017 Oct 16.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Research Center of Lipid Science and Applied Engineering Technology, South China University of Technology, Guangzhou 510640, China; Research Institute for Food Nutrition and Human Health, Guangzhou 510640, China. Electronic address:

Furan fatty acids are found in plants, algae, and fish, and reported to have some positive health benefits, including anti-oxidant and anti-inflammatory activities, and inhibition of non-enzymatic lipid peroxidation. A major metabolite of furan fatty acids, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), has been reported to be increased in patients who progress from prediabetes to type 2 diabetes, although CMPF is not necessarily associated with impaired glucose metabolism. Other studies report that CMPF levels are lower in subjects with diabetes than control subjects. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.10.002DOI Listing
October 2017
10 Reads

Modulating fat digestion through food structure design.

Prog Lipid Res 2017 10 7;68:109-118. Epub 2017 Oct 7.

Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada. Electronic address:

Dietary fats and oils are an important component of our diet and a significant contributor to total energy and intake of lipophilic nutrients and bioactives. We discuss their fate in a wide variety of engineered, processed and naturally-occurring foods as they pass through the gastrointestinal tract and the implicit role of the food matrix within which they reside. Important factors that control fat and oil digestion include: 1) Their physical state (liquid or solid); 2) Dispersion of oil as emulsion droplets and control of the interfacial structure of emulsified oils; 3) The structure and rheology of the food matrix surrounding dispersed oil droplets; and 4) Alteration of emulsified oil droplet size and concentration. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.10.001DOI Listing
October 2017
6 Reads

Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25years of research in chemistry and biology.

Prog Lipid Res 2017 10 18;68:83-108. Epub 2017 Sep 18.

School of Biological Sciences, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:

Since the beginning of the 1990's diverse types of metabolites originating from polyunsaturated fatty acids, formed under autooxidative conditions were discovered. Known as prostaglandin isomers (or isoprostanoids) originating from arachidonic acid, neuroprostanes from docosahexaenoic acid, and phytoprostanes from α-linolenic acid proved to be prevalent in biology. The syntheses of these compounds by organic chemists and the development of sophisticated mass spectrometry methods has boosted our understanding of the isoprostanoid biology. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.09.004DOI Listing
October 2017
65 Reads

Applications of nuclear magnetic resonance in lipid analyses: An emerging powerful tool for lipidomics studies.

Prog Lipid Res 2017 10 11;68:37-56. Epub 2017 Sep 11.

Department of Engineering, Faculty of Science, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark. Electronic address:

The role of lipids in cell, tissue, and organ physiology is crucial; as many diseases, including cancer, diabetes, neurodegenerative, and infectious diseases, are closely related to absorption and metabolism of lipids. Mass spectrometry (MS) based methods are the most developed powerful tools to study the synthetic pathways and metabolic networks of cellular lipids in biological systems; leading to the birth of an emerging subject lipidomics, which has been extensively reviewed. Nuclear magnetic resonance (NMR), another powerful analytical tool, which allows the visualization of single atoms and molecules, is receiving increasing attention in lipidomics analyses. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.09.003DOI Listing
October 2017
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Bacterial conjugated linoleic acid production and their applications.

Prog Lipid Res 2017 10 7;68:26-36. Epub 2017 Sep 7.

State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China. Electronic address:

Conjugated linoleic acid (CLA) has been shown to exert various potential physiological properties including anti-carcinogenic, anti-obesity, anti-cardiovascular and anti-diabetic activities, and consequently has been considered as a promising food supplement. Bacterial biosynthesis of CLA is an attractive approach for commercial production due to its high isomer-selectivity and convenient purification process. Many bacterial species have been reported to convert free linoleic acid (LA) to CLA, hitherto only the precise CLA-producing mechanisms in Propionibacterium acnes and Lactobacillus plantarum have been illustrated completely, prompting the development of recombinant technology used in CLA production. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.09.002DOI Listing
October 2017
38 Reads

The renaissance of lipoprotein(a): Brave new world for preventive cardiology?

Prog Lipid Res 2017 10 6;68:57-82. Epub 2017 Sep 6.

School of Medicine, University of Western Australia, Perth, Australia; Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Perth, Australia. Electronic address:

Lipoprotein(a) [Lp(a)] is a highly heritable cardiovascular risk factor. Although discovered more than 50 years ago, Lp(a) has recently re-emerged as a major focus in the fields of lipidology and preventive cardiology owing to findings from genetic studies and the possibility of lowering elevated plasma concentrations with new antisense therapy. Data from genetic, epidemiological and clinical studies have provided compelling evidence establishing Lp(a) as a causal risk factor for atherosclerotic cardiovascular disease. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.09.001DOI Listing
October 2017
11 Reads

Implications of glycerol metabolism for lipid production.

Prog Lipid Res 2017 10 1;68:12-25. Epub 2017 Aug 1.

(a)College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China. Electronic address:

Triacylglycerol (TAG) is an important product in oil-producing organisms. Biosynthesis of TAG can be completed through either esterification of fatty acids to glycerol backbone, or through esterification of 2-monoacylglycerol. This review will focus on the former pathway in which two precursors, fatty acid and glycerol-3-phosphate (G3P), are required for TAG formation. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.07.002DOI Listing
October 2017
13 Reads

Beyond liposomes: Recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery.

Prog Lipid Res 2017 10 1;68:1-11. Epub 2017 Aug 1.

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

Solid lipid nanoparticle (SLN), nanostructured lipid carriers (NLC) and hybrid nanoparticles, have gained increasing interest as drug delivery systems because of their potential to load and release drugs from the Biopharmaceutical classification system (BCS) of class II (low solubility and high permeability) and of class IV (low solubility and low permeability). Lipid properties (e.g. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.07.001DOI Listing
October 2017
10 Reads

Emerging roles for conjugated sterols in plants.

Prog Lipid Res 2017 07 27;67:27-37. Epub 2017 Jun 27.

Center for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Bellaterra, Spain; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain. Electronic address:

In plants, sterols are found in free form (free sterols, FSs) and conjugated as steryl esters (SEs), steryl glycosides (SGs) and acyl steryl glycosides (ASGs). Conjugated sterols are ubiquitously found in plants but their relative contents highly differ among species and their profile may change in response to developmental and environmental cues. SEs play a central role in membrane sterol homeostasis and also represent a storage pool of sterols in particular plant tissues. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.06.002DOI Listing
July 2017
4 Reads

Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.

Authors:
Daniel W Nebert

Prog Lipid Res 2017 07 9;67:38-57. Epub 2017 Jun 9.

University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267-0056, USA. Electronic address:

The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription factors, found throughout all three kingdoms of life; bHLH/PAS members "sense" innumerable intracellular and extracellular "signals" - including endogenous compounds, foreign chemicals, gas molecules, redox potential, photons (light), gravity, heat, and osmotic pressure. These signals then initiate downstream signaling pathways involved in responding to that signal. The term "PAS", abbreviation for "per-Arnt-sim" was first coined in 1991. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568781PMC
July 2017
2 Reads

HDL abnormalities in familial hypercholesterolemia: Focus on biological functions.

Prog Lipid Res 2017 07 12;67:16-26. Epub 2017 May 12.

Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran. Electronic address:

Although a selective strong elevation in the plasma level of low-density lipoprotein (LDL) cholesterol is the hallmark of familial hypercholesterolemia (FH), also other plasma lipoprotein and lipid subspecies are changed in these patients. Several studies in FH patients have pointed to the qualitative abnormalities of high-density lipoprotein (HDL) particles, including their triglyceride and sphingomyelin enrichment, reduced capacity to promote cholesterol efflux from macrophages, impaired anti-inflammatory and anti-oxidant activities, and reduced plasma levels of miRs regulating HDL-dependent cholesterol efflux from macrophage foam cells, typical of atherosclerotic lesions. Thus, accurate understanding of HDL functionality and its disturbances in FH may serve a better estimation of the prognosis and also provide additional clues when searching for novel therapeutic choices in this disease. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.05.001DOI Listing
July 2017
10 Reads
10.020 Impact Factor

Prostaglandin synthases: Molecular characterization and involvement in prostaglandin biosynthesis.

Prog Lipid Res 2017 04 7;66:50-68. Epub 2017 Apr 7.

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

Prostaglandins (PGs) belong to a subclass of eicosanoids and are classified based on the structures of the cyclopentane ring and their number of double bonds in their hydrocarbon structures. PGs are important lipid mediators that are involved in inflammatory response. The biosynthesis of diverse PGs from unsaturated C20 fatty acids containing at least three double bonds such as dihomo-γ-linoleic acid (20:3), arachidonic acid (20:4), and eicosapentaenoic acid (20:5) is enables by various PG synthases, including prostaglandin H synthase (PGHS), 15-hydroxyprostaglandin dehydrogenase (15-HPGD), PGES, PGDS, PGFS, PGIS, and thromboxane A synthase (TXAS). Read More

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http://dx.doi.org/10.1016/j.plipres.2017.04.003DOI Listing
April 2017
3 Reads

A global perspective on FOXO1 in lipid metabolism and lipid-related diseases.

Prog Lipid Res 2017 04 6;66:42-49. Epub 2017 Apr 6.

Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu, China; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China. Electronic address:

Lipid metabolism is a complex physiological process that is involved in nutrient adjustment, hormone regulation, and homeostasis. An unhealthy lifestyle and chronic nutrient overload can cause lipid metabolism disorders, which may lead to serious lipid-related diseases, including obesity, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes mellitus (T2DM). Therefore, tools for preventing dysfunctional lipid metabolism are urgently needed. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.04.002DOI Listing
April 2017
9 Reads

Oleic acid-derived oleoylethanolamide: A nutritional science perspective.

Prog Lipid Res 2017 07 5;67:1-15. Epub 2017 Apr 5.

Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg, MB R3T 6C5, Canada. Electronic address:

The fatty acid ethanolamide oleoylethanolamide (OEA) is an endogenous lipid mediator derived from the monounsaturated fatty acid, oleic acid. OEA is synthesized from membrane glycerophospholipids and is a high-affinity agonist of the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α). Dietary intake of oleic acid elevates circulating levels of OEA in humans by increasing substrate availability for OEA biosynthesis. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.04.001DOI Listing
July 2017
11 Reads

Lipids in exosomes: Current knowledge and the way forward.

Prog Lipid Res 2017 04 23;66:30-41. Epub 2017 Mar 23.

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, 0379 Oslo, Norway; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, 0379 Oslo, Norway.

Lipids are essential components of exosomal membranes, and it is well-known that specific lipids are enriched in exosomes compared to their parent cells. In this review we discuss current knowledge about the lipid composition of exosomes. We compare published data for different lipid classes in exosomes, and what is known about their lipid species, i. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.03.001DOI Listing
April 2017
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Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases.

Prog Lipid Res 2017 04 16;66:14-29. Epub 2017 Jan 16.

Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge. Cambridge, UK; Wellcome Trust Sanger Institute, Hinxton, UK. Electronic address:

Sphingolipids in general and ceramides in particular, contribute to pathophysiological mechanisms by modifying signalling and metabolic pathways. Here, we present the available evidence for a bidirectional homeostatic crosstalk between sphingolipids and glycerophospholipids, whose dysregulation contributes to lipotoxicity induced metabolic stress. The initial evidence for this crosstalk originates from simulated models designed to investigate the biophysical properties of sphingolipids in plasma membrane representations. Read More

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http://dx.doi.org/10.1016/j.plipres.2017.01.002DOI Listing
April 2017
2 Reads