1,955 results match your criteria Programmed Electrical Stimulation


Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.

J Clin Invest 2020 Jun 2. Epub 2020 Jun 2.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia of overweight and obese human subjects compared with normal-weight subjects. Read More

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http://dx.doi.org/10.1172/JCI130176DOI Listing

Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation.

Aging (Albany NY) 2020 Apr 14;12(7):6415-6435. Epub 2020 Apr 14.

Department of Pathophysiology, Basic Medical Science, Harbin Medical University, Harbin 150081, China.

The incidence of atherosclerosis (AS), a major contributor to cardiovascular disease, is steadily rising along with an increasingly older population worldwide. Pyroptosis, a form of inflammatory programmed cell death, determines the release of pro-inflammatory mediators by endothelial cells, smooth muscle cells, and atheroma-associated macrophages and foam cells, thereby playing a critical role in AS progression. Canonical pyroptosis is mediated by inflammasome formation, activation of caspase-1, and maturation and release of proinflammatory cytokines. Read More

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http://dx.doi.org/10.18632/aging.103038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185124PMC

Bepridil Inhibits Premature Ventricular Complexes Induced by Cardio-Sympathetic Nerve Stimulation in a Canine Experimental Model.

Int Heart J 2020 Mar 14;61(2):338-346. Epub 2020 Mar 14.

Cardiovascular Research, Graduate School of Health Sciences, Niigata University School of Medicine.

Sympathetic nerve activity has arrhythmogenic potential for ventricular arrhythmias associated with structural heart diseases. However, a sufficient amount of beta-blockers occasionally cannot be prescribed in some patients.An experimental study was performed to clarify the therapeutic effects of bepridil, a multiple ionic current inhibitor that does not affect beta-adrenergic receptors, for premature beats occurring during enhanced sympathetic nerve activity. Read More

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http://dx.doi.org/10.1536/ihj.19-494DOI Listing

Impact of atrial programmed electrical stimulation techniques on unipolar electrogram morphology.

J Cardiovasc Electrophysiol 2020 Apr 25;31(4):943-951. Epub 2020 Feb 25.

Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.

Introduction: Intra-atrial conduction abnormalities are associated with the development of atrial fibrillation (AF) and cause morphological changes of the unipolar atrial electrogram (U-AEGM). This study examined the impact of different atrial programmed electrical stimulation (APES) protocols on U-AEGM morphology to identify the most optimal APES protocol provoking conduction abnormalities.

Methods: APES techniques (14 protocols) were applied in 30 patients referred for an electrophysiology study, consisting of fixed rate, extra, and decremental stimuli at different frequencies. Read More

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http://dx.doi.org/10.1111/jce.14394DOI Listing

Focal Ventricular Tachycardias in Structural Heart Disease: Prevalence, Characteristics, and Clinical Outcomes After Catheter Ablation.

JACC Clin Electrophysiol 2020 Jan 27;6(1):56-69. Epub 2019 Nov 27.

Department of Cardiology, Westmead Hospital, Sydney, Australia; Westmead Applied Research Centre, University of Sydney, Sydney, Australia. Electronic address:

Objectives: This study sought to summarize the procedural characteristics and outcomes of patients with structural heart disease (SHD) who have focal ventricular tachycardia (VT).

Background: Scar-mediated re-entry is the predominant mechanism of VT in SHD. Some SHD patients may have a focal VT mechanism that remains poorly described. Read More

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http://dx.doi.org/10.1016/j.jacep.2019.09.013DOI Listing
January 2020

A model for human action potential dynamics in vivo.

Am J Physiol Heart Circ Physiol 2020 03 17;318(3):H534-H546. Epub 2020 Jan 17.

Cardiology Division of Cardiology, Veteran Affairs Medical Center, Washington, District of Columbia.

Computational modeling based on experimental data remains an important component in cardiac electrophysiological research, especially because clinical data such as human action potential (AP) dynamics are scarce or limited by practical or ethical concerns. Such modeling has been used to develop and test a variety of mechanistic hypotheses, with the majority of these studies involving the rate dependence of AP duration (APD) including APD restitution and conduction velocity (CV). However, there is very little information regarding the complex dynamics at the boundary of repolarization (or refractoriness) and reexcitability. Read More

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http://dx.doi.org/10.1152/ajpheart.00557.2019DOI Listing

A Tool to Select FES Parameters for chronic SCI

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:3799-3802

Functional electrical stimulation has been used in rehabilitation programs for patients with chronic spinal cord injury. When used correctly it is able to improve the well-being of patients. However, when the stimulus is not adequate it can accelerate the process of fatigue, reducing the time available for training the programmed motor activity. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857421DOI Listing

Cold-inducible RNA-binding protein modulates atrial fibrillation onset by targeting multiple ion channels.

Heart Rhythm 2020 Jun 7;17(6):998-1008. Epub 2020 Jan 7.

Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China; Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China; Institute of Medical Genetics, Tongji University, Shanghai, China. Electronic address:

Background: Atrial fibrillation (AF), the most common sustained arrhythmia, significantly increases cardiovascular and cerebrovascular morbidity and mortality. The pathogenesis and treatment of AF remain a major challenge in the field of cardiology. We previously found that cold-inducible RNA-binding protein (CIRP) regulated ventricular repolarization by posttranscriptionally regulating Kv4. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.12.021DOI Listing
June 2020
5.076 Impact Factor

Fibroblast growth factor 21 inhibited ischemic arrhythmias via targeting miR-143/EGR1 axis.

Basic Res Cardiol 2020 01 4;115(2). Epub 2020 Jan 4.

Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, 150081, China.

Ventricular arrhythmia is the most common cause of sudden cardiac death in patients with myocardial infarction (MI). Fibroblast growth factor 21 (FGF21) has been shown to play an important role in cardiovascular and metabolic diseases. However, the effects of FGF21 on ventricular arrhythmias following MI have not been addressed yet. Read More

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http://dx.doi.org/10.1007/s00395-019-0768-4DOI Listing
January 2020

Cardiac TRPV1 afferent signaling promotes arrhythmogenic ventricular remodeling after myocardial infarction.

JCI Insight 2020 Feb 13;5(3). Epub 2020 Feb 13.

Cardiac Arrhythmia Center and Neurocardiology Research Program.

Chronic sympathoexcitation is implicated in ventricular arrhythmogenesis (VAs) following myocardial infarction (MI), but the critical neural pathways involved are not well understood. Cardiac adrenergic function is partly regulated by sympathetic afferent reflexes, transduced by spinal afferent fibers expressing the transient receptor potential cation subfamily V member 1 (TRPV1) channel. The role of chronic TRPV1 afferent signaling in VAs is not known. Read More

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http://dx.doi.org/10.1172/jci.insight.124477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098788PMC
February 2020

Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs.

Exp Ther Med 2019 Dec 8;18(6):4347-4355. Epub 2019 Oct 8.

Department of Emergency, Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Beijing 100020, P.R. China.

The present study aimed to explore the protective effects of extracorporeal membrane oxygenation (ECMO) on intestinal mucosal injury following cardiopulmonary resuscitation (CPR), and to assess the potential mechanisms involved. A total of 24 healthy adult domestic pigs were selected as the study subjects. A ventricular fibrillation model was induced through programmed electric stimulation. Read More

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http://dx.doi.org/10.3892/etm.2019.8087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862391PMC
December 2019

Clinical Profile and Long-Term Follow-Up of Children with Brugada Syndrome.

Pediatr Cardiol 2020 Feb 20;41(2):290-296. Epub 2019 Nov 20.

First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Brugada syndrome (BrS) is a rare channelopathy associated with sudden cardiac death (SCD). Although outcome data of adult cohorts are well known, information on children are lacking. The aim of the present study was to analyze the clinical profile, treatment approach and long-term outcome of children affected with BrS. Read More

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http://dx.doi.org/10.1007/s00246-019-02254-5DOI Listing
February 2020

Comparison of maternal milk ejection characteristics during pumping using infant-derived and 2-phase vacuum patterns.

Int Breastfeed J 2019 6;14:47. Epub 2019 Nov 6.

School of Molecular Sciences, M310, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009 Australia.

Background: Milk ejection characteristics remain consistent throughout 12 months of lactation in women who expressed breastmilk with an electric breast pump. In addition these characteristics appear to remain constant when women are breastfeeding or pumping suggesting that milk ejection is a robust physiological response. It is not known whether the stimulation of an infant at the breast in the early post partum period influences milk ejection patterns or whether this is a programmed event. Read More

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http://dx.doi.org/10.1186/s13006-019-0237-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833300PMC

Design, fabrication and testing of an electrical cell stimulation and recording apparatus (ECSARA) for cells in electroculture.

Biosens Bioelectron 2020 Jan 20;147:111793. Epub 2019 Oct 20.

Center for Bioelectronics, Biosensors and Biochips (C3B), Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA; Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA; Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, USA; Department of Cardiovascular Sciences, Houston Methodist Institute for Academic Medicine and Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX, 77030, USA; ABTECH Scientific, Inc., Biotechnology Research Park, 800 East Leigh Street, Richmond, VA, 23219, USA. Electronic address:

A new dual-function electrical cell stimulation and recording apparatus (ECSARA) for simultaneously electrically stimulating cellular behavior within programmed stand-off electric fields (EFs) and monitoring cellular responses via AC electrical impedance spectroscopy (EIS) is reported. ECSARA is designed to have a footprint similar to that of a common 24-well cell culture plate within which each well is electrified via a pair of opposing planar titanium electrodes, within the cover (0.10 cm) and base (0. Read More

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http://dx.doi.org/10.1016/j.bios.2019.111793DOI Listing
January 2020

Scar shape analysis and simulated electrical instabilities in a non-ischemic dilated cardiomyopathy patient cohort.

PLoS Comput Biol 2019 10 28;15(10):e1007421. Epub 2019 Oct 28.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

This paper presents a morphological analysis of fibrotic scarring in non-ischemic dilated cardiomyopathy, and its relationship to electrical instabilities which underlie reentrant arrhythmias. Two dimensional electrophysiological simulation models were constructed from a set of 699 late gadolinium enhanced cardiac magnetic resonance images originating from 157 patients. Areas of late gadolinium enhancement (LGE) in each image were assigned one of 10 possible microstructures, which modelled the details of fibrotic scarring an order of magnitude below the MRI scan resolution. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837623PMC
October 2019
2 Reads

Unusual variants of pre-excitation: From anatomy to ablation: Part III-Clinical presentation, electrophysiologic characteristics, when and how to ablate nodoventricular, nodofascicular, fasciculoventricular pathways, along with considerations of permanent junctional reciprocating tachycardia.

J Cardiovasc Electrophysiol 2019 12 14;30(12):3097-3115. Epub 2019 Nov 14.

Post Graduation Department, Faculdade de Ciências Médicas, Belo Horizonte, Brazil.

The recognition of the presence, location, and properties of unusual accessory pathways for atrioventricular conduction is an exciting, but frequently a difficult, challenge for the clinical cardiac arrhythmologist. In this third part of our series of reviews, we discuss the different steps required to come to the correct diagnosis and management decision in patients with nodofascicular, nodoventricular, and fasciculo-ventricular pathways. We also discuss the concealed accessory atrioventricular pathways with the properties of decremental retrograde conduction that are associated with the so-called permanent form of junctional reciprocating tachycardia. Read More

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http://dx.doi.org/10.1111/jce.14247DOI Listing
December 2019
1 Read

Design of high conductive and piezoelectric poly (3,4-ethylenedioxythiophene)/chitosan nanofibers for enhancing cellular electrical stimulation.

J Colloid Interface Sci 2020 Feb 3;559:65-75. Epub 2019 Oct 3.

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address:

Electroactive nanofibrous scaffold is a vital tool for the study of the various biological research fields from bioelectronics to regenerative medicine, which can provide cell preferable 3D nanofiber architecture and programmed electrical signal. However, intrinsic non-biodegradability is a major problem that hinders its widespread application in the clinic. Herein, we designed, synthesized, and characterized shell/core poly (3,4-ethylenedioxythiophene) (PEDOT)/chitosan (CS) nanofibers by combining the electrospinning and recrystallization processes. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.10.003DOI Listing
February 2020
2 Reads

Part II-Clinical presentation, electrophysiologic characteristics, and when and how to ablate atriofascicular pathways and long and short decrementally conducting accessory pathways.

J Cardiovasc Electrophysiol 2019 12 16;30(12):3079-3096. Epub 2019 Oct 16.

Post Graduation Department, Faculdade de Ciências Médicas, Belo Horizonte, Brazil.

Recognition of the presence, location, and properties of unusual accessory pathways for atrioventricular conduction is an exciting, frequently difficult, challenge for the clinical cardiac arrhythmologist. In this second part of our series of reviews relative to this topic, we discuss the steps required to achieve the correct diagnosis and appropriate management in patients with the so-called "Mahaim" variants of pre-excitation. We indicate that, nowadays, it is recognized that these abnormal rhythms are manifest because of the presence of atriofascicular pathways. Read More

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http://dx.doi.org/10.1111/jce.14203DOI Listing
December 2019
1 Read

MicroRNA-145 Protects against Myocardial Ischemia Reperfusion Injury via CaMKII-Mediated Antiapoptotic and Anti-Inflammatory Pathways.

Oxid Med Cell Longev 2019 10;2019:8948657. Epub 2019 Sep 10.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

MicroRNA-145 (miR-145) has been shown to play an important role in cardiovascular system disorders; however, the underlying mechanism is not completely understood. The purpose of this study was aimed at elucidating the cardioprotective effects of miR-145 against myocardial ischemia/reperfusion (I/R) injury. We established a rat myocardial I/R model with 45 min left anterior descending coronary artery (LAD) occlusion and 2 h reperfusion. Read More

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http://dx.doi.org/10.1155/2019/8948657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754948PMC
March 2020
2 Reads

Effects of Angiotensin Receptor Neprilysin Inhibitors on Inducibility of Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy.

Int Heart J 2019 Sep 4;60(5):1168-1175. Epub 2019 Sep 4.

Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University.

The aims of the present study were to investigate the effects of angiotensin receptor neprilysin inhibitors (ARNi) on the susceptibility of ventricular arrhythmias (VAs) in rats with myocardial infarction (MI) and to explore the related mechanisms.A total of 32 adult male Sprague-Dawley rats were divided into 3 groups: a control group, MI group, and MI+ARNi group. MI was generated by ligation of the left anterior descending coronary artery. Read More

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http://dx.doi.org/10.1536/ihj.19-065DOI Listing
September 2019
5 Reads

[Effects and mechanism of digoxin on atrium electrical remodeling and susceptibility of atrial fibrillation in aged rabbits].

Zhonghua Xin Xue Guan Bing Za Zhi 2019 Aug;47(8):608-613

Department of Cardiology, Renmin Hospital of Wuhan University & Cardiovascular Research Institute of Wuhan University, Wuhan 430060, China.

To investigate the effects and mechanism of digoxin on atrium electrical remodeling and susceptibility of atrial fibrillation (AF) in aged rabbits. Twenty aged male New Zealand rabbits were divided into aged group and aged plus digoxin group (10 each). Electrical parameters including heart rate (HR), RR and QT interval, ST segment and P wave dispersion from normal Ⅱ electrocardiogram, and the maximum upstroke velocity (Max(dv/dt)), plateau potential (plateau P), action potential duration of 10%, 20% and 90% (APD(10), APD(20), APD(90)) from recording of monophasic action potential (MAP), as well as atrial effective refractory period (AERP(200)) and dispersion (dERP(200)) with 200 ms of basic cycle length (BCL), and frequency self adaptation of AERP with 300 ms and 150 ms of BCLs (fERP) were recorded and compared between the 2 groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253.3758.2019.08.004DOI Listing
August 2019
4 Reads

Improving an open-source commercial system to reliably perform activity-dependent stimulation.

J Neural Eng 2019 10 29;16(6):066022. Epub 2019 Oct 29.

Department of Rehabilitation Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, 66160 KS, United States of America. Bioengineering Graduate Program, University of Kansas, Lawrence, KS, United States of America.

Objective: Activity-dependent stimulation (ADS) is designed to strengthen the connections between neuronal circuits and therefore may be a promising tool for promoting neurophysiological reorganization following a brain injury. To successfully perform this technique, two criteria must be met: (1) spikes in the extracellular electrical field potential must be detected accurately at one site of interest, and (2) stimulation pulses generated at fixed (<1 ms jitter), low-latency (<10 ms) intervals relative to each detected spike must be delivered reliably to a second site of interest. Here, we aimed to improve noise rejection in a low-cost commercial system to reliably perform ADS in awake, behaving rats, while maintaining latency requirements. Read More

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http://dx.doi.org/10.1088/1741-2552/ab3319DOI Listing
October 2019
4 Reads

Applications of Cardiac MR Imaging in Electrophysiology: Current Status and Future Needs.

Magn Reson Imaging Clin N Am 2019 Aug;27(3):465-473

Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Johns Hopkins Medicine, 600 North Wolfe Street, Blalock 536, Baltimore, MD 21287, USA. Electronic address:

The potential role of cardiac MR imaging in the diagnosis, risk-stratification, and treatment of patients with cardiac arrhythmias is rapidly evolving. Beyond substrate identification and characterization, it is now feasible to perform MR imaging-based noninvasive virtual programmed stimulation to identify potential ablation targets. The next phase of MR imaging-guided electrophysiology may involve intraprocedural guidance of electrophysiologic interventions using real-time MR imaging. Read More

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http://dx.doi.org/10.1016/j.mric.2019.04.006DOI Listing
August 2019
4 Reads

Electrophysiologic testing for diagnostic evaluation and risk stratification in patients with suspected cardiac sarcoidosis with preserved left and right ventricular systolic function.

J Cardiovasc Electrophysiol 2019 10 23;30(10):1939-1948. Epub 2019 Jul 23.

Division of Cardiology, Section of Cardiac Electrophysiology, University of Colorado, Aurora, Colorado.

Introduction: While cardiac sarcoidosis (CS) carries a risk of ventricular arrhythmias (VAs) and sudden cardiac death (SCD), risk stratification of patients with CS and preserved left ventricular/right ventricular (LV/RV) systolic function remains challenging. We sought to evaluate the role of electrophysiologic testing and programmed electrical stimulation of the ventricle (EPS) in patients with suspected CS with preserved ventricular function.

Methods: One hundred twenty consecutive patients with biopsy-proven extracardiac sarcoidosis and preserved LV/RV systolic function underwent EPS. Read More

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http://dx.doi.org/10.1111/jce.14058DOI Listing
October 2019
9 Reads

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.

Circulation 2019 08 12;140(8):681-693. Epub 2019 Jun 12.

Integrative Molecular and Biomedical Sciences (K.M.A., N.L., X.H.T.W.), Baylor College of Medicine, Houston, TX.

Background: Abnormal calcium (Ca) release from the sarcoplasmic reticulum (SR) contributes to the pathogenesis of atrial fibrillation (AF). Increased phosphorylation of 2 proteins essential for normal SR-Ca cycling, the type-2 ryanodine receptor (RyR2) and phospholamban (PLN), enhances the susceptibility to AF, but the underlying mechanisms remain unclear. Protein phosphatase 1 (PP1) limits steady-state phosphorylation of both RyR2 and PLN. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699925PMC
August 2019
25 Reads

Multiple Shifts of the Earliest Retrograde Atrial Activation Site Along the Tricuspid Annulus During the Fast-Slow Form of Atrioventricular Nodal Reentrant Tachycardia by Radiofrequency Modification.

Int Heart J 2019 May 17;60(3):761-767. Epub 2019 May 17.

Cardiovascular Center, Sakurabashi-Watanabe Hospital.

A 70-year-old woman was admitted for treatment of supraventricular tachycardia. Ventriculoatrial conduction was revealed through programmed ventricular stimulation; the coronary sinus ostium (CSos) was the earliest atrial activation site. The fast-slow forms of atrioventricular nodal reentrant tachycardia (AVNRT) were induced by ventricular extra-stimuli. Read More

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http://dx.doi.org/10.1536/ihj.18-406DOI Listing
May 2019
9 Reads

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications.

Acta Biomater 2019 07 7;92:145-159. Epub 2019 May 7.

Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Israel; Cardiology Department, Rambam Health Care Campus, Israel. Electronic address:

Cardiac tissue engineering provides unique opportunities for cardiovascular disease modeling, drug testing, and regenerative medicine applications. To recapitulate human heart tissue, we combined human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with a chitosan-enhanced extracellular-matrix (ECM) hydrogel, derived from decellularized pig hearts. Ultrastructural characterization of the ECM-derived engineered heart tissues (ECM-EHTs) revealed an anisotropic muscle structure, with embedded cardiomyocytes showing more mature properties than 2D-cultured hiPSC-CMs. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.05.016DOI Listing
July 2019
11 Reads

Platelets as platforms for inhibition of tumor recurrence post-physical therapy by delivery of anti-PD-L1 checkpoint antibody.

J Control Release 2019 06 6;304:233-241. Epub 2019 May 6.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren'ai Road, Suzhou 215123, Jiangsu, PR China. Electronic address:

Cancer local physical therapy (PT) by using heat, cold, electrical stimulation, irradiation or ultrasound to treat tumor is accepted as alternative choice for cancer patients. However, local recurrence and metastasis after such treatments remains to be the major cause of treatment failure and mortality. Therefore, it is necessary to develop a therapeutic strategy to inhibit local recurrence and metastasis. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.05.008DOI Listing
June 2019
9 Reads

A rat model of complete atrioventricular block recapitulates clinical indices of bradycardia and provides a platform to test disease-modifying therapies.

Sci Rep 2019 05 6;9(1):6930. Epub 2019 May 6.

Department of Pediatrics, Emory University, Atlanta, GA, USA.

Complete atrioventricular block (CAVB) is a life-threatening arrhythmia. A small animal model of chronic CAVB that properly reflects clinical indices of bradycardia would accelerate the understanding of disease progression and pathophysiology, and the development of therapeutic strategies. We sought to develop a surgical model of CAVB in adult rats, which could recapitulate structural remodeling and arrhythmogenicity expected in chronic CAVB. Read More

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http://dx.doi.org/10.1038/s41598-019-43300-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502940PMC
May 2019
13 Reads

Inertial measurement unit compared to an optical motion capturing system in post-stroke individuals with foot-drop syndrome.

Ann Phys Rehabil Med 2020 May 19;63(3):195-201. Epub 2019 Apr 19.

Physical Medicine and Rehabilitation, Nîmes University Hospital, 30240 Le Grau du Roi, France.

Background: Functional electrical stimulation (FES) can be used for compensation of foot-drop for post-stroke individuals by pre-programmed fixed stimulation; however, this stimulation seems no more effective than mechanical ankle foot orthoses.

Objective: We evaluated the metrological quality of inertial sensors for movement reconstruction as compared with the gold-standard motion capturing system, to couple FES with inertial sensors to improve dorsiflexion on the paretic side, by using an adaptive stimulation taking into account individuals' performance post-stroke.

Methods: Adults with ischemic or hemorrhagic stroke presenting foot-drop and able to walk 10m, were included from May 2016 to June 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18770657193005
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http://dx.doi.org/10.1016/j.rehab.2019.03.007DOI Listing
May 2020
39 Reads

When and how does a single ventricular premature beat initiate and terminate supraventricular tachycardia?

Ann Noninvasive Electrocardiol 2019 09 16;24(5):e12650. Epub 2019 Apr 16.

Faculdade Ciências Médicas, Ciências Médicas-MG, Belo Horizonte, Brazil.

Background: The differential diagnosis of a supraventricular tachycardia (SVT) is accomplished using a number of pacing maneuvers. The incidence and mechanism of a single ventricular premature beat (VPB) on initiation and termination of tachycardia were evaluated during programmed electrical stimulation (PES) of the heart in patients with the two most common regular SVTs: atrioventricular re-entrant tachycardia (AVNRT) and orthodromic atrioventricular tachycardia (AVRT).

Methods: Three hundred and thirty-seven consecutive patients aged above 18 years with an inducible sustained AVNRT or AVRT were prospectively enrolled. Read More

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http://dx.doi.org/10.1111/anec.12650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931473PMC
September 2019
8 Reads

TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-κB pathway and ROS production.

Redox Biol 2019 06 2;24:101186. Epub 2019 Apr 2.

Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China. Electronic address:

Sympathetic nerve hyperactivity is a primary reason for fatal ventricular arrhythmias (VAs) following myocardial infarction (MI). Pro-inflammatory cytokines produced in the paraventricular nucleus (PVN) post-MI are associated with sympathetic overexcitation; however, the precise mechanism needs further investigation. Our aim was to explore the mechanism of toll-like receptor 4 (TLR4) and its downstream molecular pathway in mediating sympathetic activity post-MI within the PVN. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460304PMC
June 2019
6 Reads

Exchange-protein activated by cAMP (EPAC) regulates L-type calcium channel in atrial fibrillation of heart failure model.

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):2200-2207

Department of Cardiovascular Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China.

Objective: Both atrial fibrillation (AF) and heart failure (HF) are increasingly prevalent and related to high hospitalization rate and mortality. AF is a cause as well as a consequence of HF, with complicated interactions resulting in impairment of cardiac systolic and diastolic function. Conversely, the complex structural and neurohormonal alterations in HF contribute to the occurrence and development of AF. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17267DOI Listing
March 2019
6 Reads

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release.

Molecules 2019 Mar 21;24(6). Epub 2019 Mar 21.

Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey CP 64849, Mexico.

In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. This particular work focuses on the smart chemistry and mechanism of action aspects of several types of stimuli-responsive polymeric carriers that play a crucial role in extracellular and intracellular sections of diseased tissues or cells. With ever increasing scientific knowledge and awareness, research is underway around the globe to design new types of stimuli (external/internal) responsive polymeric carriers for biotechnological applications at large and biomedical and/or pharmaceutical applications, in particular. Read More

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http://dx.doi.org/10.3390/molecules24061117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470858PMC
March 2019
9 Reads
2.416 Impact Factor

Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure.

Stem Cell Res Ther 2019 03 7;10(1):78. Epub 2019 Mar 7.

Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Rm 1928, Block K, Hong Kong SAR, China.

Background: Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC-MSCs) in a porcine model of HF.

Methods: Eight weeks after induction of HF with myocardial infarction (MI) and rapid pacing, animals with impaired left ventricular ejection fraction (LVEF) were randomly assigned to receive direct intramyocardial injection of saline (MI group), 2 × 10 hESC-CMs (hESC-CM group), or 2 × 10 hiPSC-MSCs (hiPSC-MSC group). Read More

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http://dx.doi.org/10.1186/s13287-019-1183-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407247PMC
March 2019
11 Reads

Multispectral optoacoustic imaging of dynamic redox correlation and pathophysiological progression utilizing upconversion nanoprobes.

Nat Commun 2019 03 6;10(1):1087. Epub 2019 Mar 6.

Sino-Singapore International Joint Research Institute (SSIJRI), Guangzhou, 510000, China.

Precise and differential profiling of the dynamic correlations and pathophysiological implications of multiplex biological mediators with deep penetration and highly programmed precision remain critical challenges in clinics. Here we present an innovative strategy by tailoring a powerful multispectral optoacoustic tomography (MSOT) technique with a photon-upconverting nanoprobe (UCN) for simultaneous visualization of diversely endogenous redox biomarkers with excellent spatiotemporal resolution in living conditions. Upon incorporating two specific radicals-sensitive NIR cyanine fluorophores onto UCNs surface, such nanoprobes can orthogonally respond to disparate oxidative and nitrosative stimulation, and generate spectrally opposite optoacoustic signal variations, which thus achieves compelling superiorities for reversed ratiometric tracking of multiple radicals under dual independent wavelength channels, and significantly, for precise validating of their complex dynamics and correlations with redox-mediated pathophysiological procession in vivo. Read More

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http://dx.doi.org/10.1038/s41467-019-09001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403272PMC
March 2019
8 Reads

Remotely programmed sacral neuromodulation for the treatment of patients with refractory overactive bladder: a prospective randomized controlled trial evaluating the safety and efficacy of a novel sacral neuromodulation device.

World J Urol 2019 Nov 26;37(11):2481-2492. Epub 2019 Feb 26.

Urology Department, Beijing Hospital, National Center of Gerontology, No. 1 DaHua Road, Dong Dan, Beijing, 100730, People's Republic of China.

Purpose: The efficacy and safety of a novel remotely programmed BetterStim sacral neuromodulation (SNM) system was evaluated in patients with refractory overactive bladder (OAB) in a prospective, controlled, multicenter trial.

Methods: A total of 84 patients referred for SNM therapy from October 2015 to January 2018 were studied. Of the patients who qualified for implantation, 37 and 33 were randomly assigned to treatment and control groups, respectively. Read More

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http://dx.doi.org/10.1007/s00345-019-02698-7DOI Listing
November 2019
26 Reads
2.666 Impact Factor

Reflections on the early invasive clinical cardiac electrophysiology era through fifty manuscripts: 1967-1992.

J Arrhythm 2019 Feb 3;35(1):7-17. Epub 2018 Dec 3.

Division of Cardiovascular Medicine University of Miami Miller School of Medicine Miami Florida.

In 1967, researchers in The Netherlands and France independently reported a new technique, later called programmed electrical stimulation. The ability to reproducibly initiate and terminate arrhythmias heralded the beginning of invasive clinical cardiac electrophysiology as a medical discipline. Over the next fifty years, insights into the pathophysiologic basis of arrhythmias would transform the field into an interventional specialty with a tremendous armamentarium of procedures. Read More

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http://dx.doi.org/10.1002/joa3.12143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373646PMC
February 2019
6 Reads

Upregulation of MMP-9 and CaMKII prompts cardiac electrophysiological changes that predispose denervated transplanted hearts to arrhythmogenesis after prolonged cold ischemic storage.

Biomed Pharmacother 2019 Apr 20;112:108641. Epub 2019 Feb 20.

Department of Anaesthesiology, Guizhou Medical University, Guiyang, China.

Background: Although the importance of the potential mechanisms of arrhythmogenesis, including cardiac electrophysiology dysfunction and gap junction electrical uncoupling by Cx43 degradation under pathological conditions, has been widely and thoroughly established, the correlations between these mechanisms and biomarkers of cold ischemic insult have not yet been confirmed. Limited evidence suggests that these biomarkers are significantly associated with cardiac dysrhythmia. Thus, in this study, we analyzed such correlations in denervated transplanted hearts. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108641DOI Listing
April 2019
7 Reads

Importance of the vein of Marshall involvement in mitral isthmus ablation.

Pacing Clin Electrophysiol 2019 06 3;42(6):617-624. Epub 2019 Apr 3.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Background: Epicardiac conduction via the vein of Marshall (VOM) can bypass the mitral isthmus (MI) line, making MI ablation difficult. This study aimed to assess the contribution of the VOM in achieving MI conduction block.

Methods: This study included 143 consecutive patients with nonparoxysmal atrial fibrillation who underwent initial MI ablation. Read More

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http://dx.doi.org/10.1111/pace.13640DOI Listing
June 2019
26 Reads

Restoration of Upper Limb Function After Chronic Severe Hemiplegia: A Case Report on the Feasibility of a Brain-Computer Interface-Triggered Functional Electrical Stimulation Therapy.

Am J Phys Med Rehabil 2020 03;99(3):e35-e40

From the Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada (LIJ, NK, LL, VZ, MRP, CM-C); Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada (LIJ, MRP); and Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada (NK, MRP).

Functional electrical stimulation therapy (FEST) is a state-of-the-art treatment for retraining motor function after neurological injuries. Recent literature suggests that FEST can be further improved with brain-computer interface (BCI) technology. In this case study, we assessed the feasibility of using BCI-triggered FEST (BCI-FEST) to restore upper limb function in a 57-yr-old man with severe left hemiplegia resulting from a stroke 6 yrs before enrollment in the study. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001163DOI Listing
March 2020
7 Reads

Bipolar active fixation left ventricular lead or quadripolar passive fixation lead? An Italian multicenter experience.

J Cardiovasc Med (Hagerstown) 2019 Apr;20(4):192-200

Azienda Ospedaliera Universitaria S. Orsola-Malpighi, Bologna.

Aims: About one-third of patients receiving cardiac resynchronization therapy (CRT) are not responders, due to either patient selection or technical issues. Left ventricular quadripolar passive fixation leads (QPL) and bipolar active fixation (BAF) leads have been designed to ensure a targeted left ventricular stimulation area, minimizing lead dislodgments and phrenic nerve stimulation (PNS). The aim was to compare real-world safety and efficacy of BAF (Attain Stability, Medtronic Plc. Read More

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http://Insights.ovid.com/crossref?an=01244665-201904000-0000
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http://dx.doi.org/10.2459/JCM.0000000000000778DOI Listing
April 2019
36 Reads

Immunobiochemical Reconstruction of Influenza Lung Infection-Melanoma Skin Cancer Interactions.

Front Immunol 2019 28;10. Epub 2019 Jan 28.

Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, United States.

It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapable of migrating back to the tumor site. At the same time, co-infection virus-specific CD8+ T cells remained functional while the infection was cleared. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360404PMC
December 2019
3 Reads

Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368.

BMC Anesthesiol 2019 01 8;19(1). Epub 2019 Jan 8.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

Background: Reperfusion ventricular arrhythmia (RA) associated with hypothermic ischaemic storage is increasingly recognized as a substantial contributor to adverse consequences after heart transplantation. Ischemia- or hypothermia-induced gap junction (GJ) remodelling is closely linked to RA. Reducing GJ remodelling contributes to RA attenuation and is important in heart transplantation. Read More

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http://dx.doi.org/10.1186/s12871-018-0656-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325883PMC
January 2019
9 Reads
1.333 Impact Factor

Computational Study of the Effect of Electrode Polarity on Neural Activation Related to Paresthesia Coverage in Spinal Cord Stimulation Therapy.

Neuromodulation 2019 Apr 26;22(3):269-279. Epub 2018 Dec 26.

Center of Research and Innovation in Bioengineering, Universitat Politècnica de València, Valencia, Spain.

Objective: Using computer simulation, we investigated the effect of electrode polarity on neural activation in spinal cord stimulation and propose a new strategy to maximize the activating area in the dorsal column (DC) and, thus, paresthesia coverage in clinical practice.

Materials And Methods: A new three-dimensional spinal cord model at the T10 vertebral level was developed to simulate neural activation induced by the electric field distribution produced by different typical four-contact electrode polarities in single- and dual-lead stimulation. Our approach consisted of the combination of a finite element model of the spinal cord developed in COMSOL Multiphysics and a nerve fiber model implemented in MATLAB. Read More

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http://dx.doi.org/10.1111/ner.12909DOI Listing
April 2019
7 Reads

Prevalence of spontaneous type I ECG pattern, syncope, and other risk markers in sudden cardiac arrest survivors with Brugada syndrome.

Pacing Clin Electrophysiol 2019 02 6;42(2):257-264. Epub 2019 Jan 6.

Imperial College Healthcare NHS Trust, London, UK.

Introduction: A spontaneous type I electrocardiogram (ECG) pattern and/or unheralded syncope are conventionally used as risk markers for primary prevention of sudden cardiac arrest/death (SCA/SCD) in Brugada syndrome (BrS). In this study, we determine the prevalence of conventional and newer markers of risk in those with and without previous aborted SCA events.

Methods: All patients with BrS were identified at our institute. Read More

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http://dx.doi.org/10.1111/pace.13587DOI Listing
February 2019
11 Reads

Electroanatomic and Pathologic Right Ventricular Outflow Tract Abnormalities in Patients With Brugada Syndrome.

J Am Coll Cardiol 2018 12;72(22):2747-2757

Cardiovascular Department, San Donato Hospital, Arezzo, Italy.

Background: The prevalence and significance of structural abnormalities in Brugada syndrome (BrS) are still largely debated.

Objectives: The authors investigated the relationship between genetic background, electroanatomic abnormalities, and pathologic substrate in BrS.

Methods: They performed 3-dimensional electroanatomic unipolar and bipolar mapping in 30 patients with BrS. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.09.037DOI Listing
December 2018
10 Reads

Targeted regulation of sympathetic activity in paraventricular nucleus reduces inducible ventricular arrhythmias in rats after myocardial infarction.

J Cardiol 2019 01 4;73(1):81-88. Epub 2018 Jul 4.

Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China. Electronic address:

Background: The hypothalamic paraventricular nucleus (PVN) is the center of the regulation of autonomic nervous system functions and cardiovascular activity. Phosphoinositide-3 kinase (PI3K)-AKT pathway in PVN contributes to mediate sympathetic nerve activity and is activated in spontaneously hypertensive rats. Overactivation of the sympathetic output was considered as an important mechanism of the arrhythmias. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.06.003DOI Listing
January 2019
43 Reads
2.566 Impact Factor

Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat.

J Cell Mol Med 2019 01 24;23(1):112-125. Epub 2018 Oct 24.

School of Medicine, Shandong University, Jinan, China.

Malignant ventricular arrhythmias (VAs) following myocardial infarction (MI) is a lethal complication resulting from sympathetic nerve hyperactivity. Numerous evidence have shown that inflammation within the paraventricular nucleus (PVN) participates in sympathetic hyperactivity. Our aim was to explore the role of Macrophage-inducible C-type lectin (Mincle) within the PVN in augmenting sympathetic activity following MI,and whether NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome/IL-1β axis is involved in this activity. Read More

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http://doi.wiley.com/10.1111/jcmm.13890
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http://dx.doi.org/10.1111/jcmm.13890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307841PMC
January 2019
47 Reads

Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure.

Drug Des Devel Ther 2018 10;12:3407-3418. Epub 2018 Oct 10.

Heart Center, Guangdong Provincial Hospital of Chinese Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China,

Purpose: Shensong Yangxin (SSYX) capsule is a traditional Chinese medicine that has been used widely to treat cardiac arrhythmia. This study aimed to assess whether SSYX prevents atrial fibrillation (AF) after chronic myocardial infarction (MI)-induced heart failure and to determine the underlying mechanisms.

Materials And Methods: The study included 45 male Sprague Dawley rats. Read More

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http://dx.doi.org/10.2147/DDDT.S182834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186904PMC
March 2019
6 Reads