2,043 results match your criteria Programmed Electrical Stimulation

Danqi soft caspule prevents atrial fibrillation by ameliorating left atrial remodeling through inhibiting cardiac fibroblasts differentiation and function.

Phytomedicine 2022 Jul 26;101:154134. Epub 2022 Apr 26.

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. Electronic address:

Background: Danqi soft capsule (DQ) is a Chinese herb medicine with a remarkable protective effect on cardio-cerebrovascular diseases.

Purpose: The study aimed to investigate the role and mechanism of DQ on left atrial (LA) remodeling and atrial fibrillation (AF) occurrence in rats with post-myocardial infarction (MI) induced heart failure (HF).

Methods: MI in rats was established by ligation of the left anterior descending coronary artery. Read More

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Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer GSDME-Mediated Pyroptosis.

Front Pharmacol 2022 20;13:860546. Epub 2022 Apr 20.

Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.

Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation. Silenced GSDME expression due to promoter hypermethylation is associated with gastric cancer (GC), which is confirmed in the present study by bioinformatics analysis and methylation-specific PCR (MSP) test of GC cell lines and clinical samples. GC cell lines and mouse xenograft models were used to investigate the pyroptosis-inducing effect of the common cholesterol-depleting, drug simvastatin (SIM), allied with upregulating GSDME expression by doxycycline (DOX)- inducible Tet-on system or DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-Aza-CdR). Read More

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Theoretical modeling of dendrite growth from conductive wire electro-polymerization.

Sci Rep 2022 Apr 16;12(1):6395. Epub 2022 Apr 16.

Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520-IEMN, 59000, Lille, France.

Electropolymerization is a bottom-up materials engineering process of micro/nano-scale that utilizes electrical signals to deposit conducting dendrites morphologies by a redox reaction in the liquid phase. It resembles synaptogenesis in the brain, in which the electrical stimulation in the brain causes the formation of synapses from the cellular neural composites. The strategy has been recently explored for neuromorphic engineering by establishing link between the electrical signals and the dendrites' shapes. Read More

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Pathogenesis and Management of Brugada Syndrome: Recent Advances and Protocol for Umbrella Reviews of Meta-Analyses in Major Arrhythmic Events Risk Stratification.

J Clin Med 2022 Mar 30;11(7). Epub 2022 Mar 30.

Department of Electrocardiology, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, 31-202 Kraków, Poland.

Brugada syndrome (BrS) is a primary electrical disease associated with life-threatening arrhythmias. It is estimated to cause at least 20% of sudden cardiac deaths (SCDs) in patients with normal cardiac anatomy. In this review paper, we discuss recent advances in complex BrS pathogenesis, diagnostics, and current standard approaches to major arrhythmic events (MAEs) risk stratification. Read More

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Effect of TLR4/MyD88/NF-kB axis in paraventricular nucleus on ventricular arrhythmias induced by sympathetic hyperexcitation in post-myocardial infarction rats.

J Cell Mol Med 2022 May 8;26(10):2959-2971. Epub 2022 Apr 8.

Department of Cardiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Sympathetic activation after myocardial infarction (MI) leads to ventricular arrhythmias (VAs), which can result in sudden cardiac death (SCD). The toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor-kappa B (NF-kB) axis within the hypothalamic paraventricular nucleus (PVN), a cardiac-neural sympathetic nerve centre, plays an important role in causing VAs. An MI rat model and a PVN-TLR4 knockdown model were constructed. Read More

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Shape Memory Nitinol Based Minimally Invasive Spinal Cord Stimulation Device Concept for Improved Pain Management.

Pain Physician 2022 03;25(2):E375-E383

Center for Biomedical Engineering, Brown University, Providence, RI; School of Engineering, Brown University, Providence, RI.

Background: Spinal cord stimulation (SCS) is a common treatment for neuropathic pain. There are 2 main categories of SCS leads: paddle leads and cylindrical leads. Paddle leads have reduced long-term complications and provide better coverage of target dermatomes when compared to cylindrical leads. Read More

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In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability.

Nat Protoc 2022 05 21;17(5):1189-1222. Epub 2022 Mar 21.

Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany.

The mouse is a common and cost-effective animal model for basic research, and the number of genetically engineered mouse models with cardiac phenotype is increasing. In vivo electrophysiological study in mice is similar to that performed in humans. It is indispensable for acquiring intracardiac electrocardiogram recordings and determining baseline cardiac cycle intervals. Read More

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A defined human-specific platform for modeling neuronal network stimulation in vitro and in silico.

J Neurosci Methods 2022 May 12;373:109562. Epub 2022 Mar 12.

Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Germany. Electronic address:

Background: Transcription factor-based forward programming enables the efficient generation of forebrain excitatory and inhibitory neurons from human pluripotent stem cells (hPSCs). This provides an opportunity to study stimulation-response patterns in highly defined neuronal networks in a controlled and customizable in vitro environment.

New Method: Cell populations composed of defined ratios of excitatory and inhibitory neurons were generated by forward programming genome-edited human hPSCs carrying the inducible transcription factors NGN2 and ASCL1/DLX2, respectively. Read More

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Self-powered smart patch promotes skin nerve regeneration and sensation restoration by delivering biological-electrical signals in program.

Biomaterials 2022 04 17;283:121413. Epub 2022 Feb 17.

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, PR China. Electronic address:

Skin wound is always accompanied with nerve destruction. Due to the limited clinical treatment option, loss of skin sensation with unsatisfactory nerve regeneration is remained to be a challenge for wound therapy. Endogenous mesenchymal stem cells (MSCs) based in situ regeneration, of which, MSCs recruited by chemokines and directed for neuronal differentiation by biological and electrical signals have been thought a novel strategy with potential to accelerate the nerve regeneration and sensory functions recovery. Read More

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Biological substrate modification suppresses ventricular arrhythmias in a porcine model of chronic ischaemic cardiomyopathy.

Eur Heart J 2022 Mar 9. Epub 2022 Mar 9.

Smidt Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.

Aims: Cardiomyopathy patients are prone to ventricular arrhythmias (VA) and sudden cardiac death. Current therapies to prevent VA include radiofrequency ablation to destroy slowly conducting pathways of viable myocardium which support re-entry. Here, we tested the reverse concept, namely that boosting local tissue viability in zones of slow conduction might eliminate slow conduction and suppress VA in ischaemic cardiomyopathy. Read More

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Electrical stimulation waveform-dependent osteogenesis on PVDF/BaTiO composite using a customized and programmable cell stimulator.

Biotechnol Bioeng 2022 Jun 27;119(6):1578-1597. Epub 2022 Mar 27.

Laboratory for Biomaterials, Materials Research Centre, Indian Institute of Science, Bangalore, India.

Directing cellular functionalities using biomaterial-based bioelectronic stimulation remains a significant constraint in translating research outcomes to address specific clinical needs. Electrical stimulation is now being clinically used as a therapeutic treatment option to promote bone tissue regeneration and to improve neuromuscular functionalities. However, the nature of the electrical waveforms during the stimulation and underlying biophysical rationale are still not scientifically well explored. Read More

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Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome.

Rev Cardiovasc Med 2022 Jan;23(2):44

Division of Cardiology, Queen's University, Kingston General Hospital, Kingston, K7K Ontario, Canada.

Brugada syndrome (BrS) is a complex arrhythmogenic disease displaying electrical and micro-structural abnormalities mainly located at the epicardium of the right ventricular outflow tract (RVOT). It is well-known that fibrosis, fatty infiltration, inflammation and reduced gap junction expression have been demonstrated at the epicardial anterior aspect of the RVOT providing the arrhythmogenic substrate for ventricular arrhythmic events in BrS. A number of models have been proposed for the risk stratification of patients with BrS. Read More

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January 2022

Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice.

Acta Biochim Biophys Sin (Shanghai) 2022 01;54(2):199-208

Key Laboratory of Cell Transplantation, the First Affiliated Hospital, Harbin Medical University, Harbin 150086, China.

Methyltransferase-like 3 (Mettl3) is a component of methyltransferase complex that mediates mA modification of RNAs, and participates in multiple biological processes. However, the role of Mettl3 in cardiac electrophysiology remains unknown. This study aims to explore the ventricular arrhythmia susceptibility of Mettl3 mice and the underlying mechanisms. Read More

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January 2022

Optogenetic Control of Human Induced Pluripotent Stem Cell-Derived Cardiac Tissue Models.

J Am Heart Assoc 2022 02 3;11(4):e021615. Epub 2022 Feb 3.

Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine The Rappaport Faculty of Medicine and Research InstituteTechnion‒Israel Institute of Technology Haifa Israel.

Background Optogenetics, using light-sensitive proteins, emerged as a unique experimental paradigm to modulate cardiac excitability. We aimed to develop high-resolution optogenetic approaches to modulate electrical activity in 2- and 3-dimensional cardiac tissue models derived from human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Methods and Results To establish light-controllable cardiac tissue models, opsin-carrying HEK293 cells, expressing the light-sensitive cationic-channel CoChR, were mixed with hiPSC-cardiomyocytes to generate 2-dimensional hiPSC-derived cardiac cell-sheets or 3-dimensional engineered heart tissues. Read More

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February 2022

New insights into the central sympathetic hyperactivity post-myocardial infarction: Roles of METTL3-mediated m A methylation.

J Cell Mol Med 2022 02 17;26(4):1264-1280. Epub 2022 Jan 17.

Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China.

Ventricular arrhythmias (VAs) triggers by sympathetic nerve hyperactivity contribute to sudden cardiac death in myocardial infarction (MI) patients. Microglia-mediated inflammation in the paraventricular nucleus (PVN) is involved in sympathetic hyperactivity after MI. N6-methyladenosine (m A), the most prevalent mRNA and epigenetic modification, is critical for mediating cell inflammation. Read More

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February 2022

Restoring Hand Functions in People with Tetraplegia through Multi-Contact, Fascicular, and Auto-Pilot Stimulation: A Proof-of-Concept Demonstration.

J Neurotrauma 2022 May 2;39(9-10):627-638. Epub 2022 Feb 2.

INRIA, University of Montpellier, Montpellier, France.

Two multi-contact epineural electrodes were placed around radial and median nerves of two subjects with high tetraplegia C4, American Spinal Injury Association Impairment Scale (AIS) A, group 0 of the International Classification for Surgery of the Hand in Tetraplegia. The purpose was to study the safety and capability of these electrodes to generate synergistic motor activation and functional movements and to test control interfaces that allow subjects to trigger pre-programmed stimulation sequences. The device consists of a pair of neural cuff electrodes and percutaneous cables with two extracorporeal connection cables inserted during a surgical procedure and maintained for 28 days. Read More

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Rationale and study design of the MINERVA study: Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction-UK multicentre collaboration.

BMJ Open 2022 Jan 3;12(1):e059527. Epub 2022 Jan 3.

NIHR Leicester Biomedical Research Centre Cardiovascular Diseases, Leicester, UK.

Introduction: The purpose of this study is to assess the ability of two new ECG markers (Regional Repolarisation Instability Index (R2I2) and Peak Electrical Restitution Slope) to predict sudden cardiac death (SCD) or ventricular arrhythmia (VA) events in patients with ischaemic cardiomyopathy undergoing implantation of an implantable cardioverter defibrillator for primary prevention indication.

Methods And Analysis: Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction is a prospective, open label, single blinded, multicentre observational study to establish the efficacy of two ECG biomarkers in predicting VA risk. 440 participants with ischaemic cardiomyopathy undergoing routine first time implantable cardioverter-defibrillator (ICD) implantation for primary prevention indication are currently being recruited. Read More

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January 2022

Is Endurance Training Harmful to Older Athletes in the Long Run? An Interesting Case of Exercise-Induced Ventricular Tachycardia.

Cureus 2021 Nov 17;13(11):e19665. Epub 2021 Nov 17.

Cardiology, Aventura Hospital and Medical Center, Aventura, USA.

There is limited data on how endurance training can impact cardiac function and arrhythmogenesis. Intense endurance training has been associated with pathological remodeling of the right ventricle (RV) that can act as a substrate for fatal ventricular arrhythmias in older athletes. A previously healthy 63-year-old female marathon runner presented with symptomatic monomorphic ventricular tachycardia (VT) while exercising. Read More

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November 2021

Programmed electrical (nerve) stimulation and extensive left atrial denervation in patients with paroxysmal atrial fibrillation.

Robert Lemery

Heart Rhythm 2022 04 25;19(4):525-526. Epub 2021 Dec 25.

Arizona Heart Rhythm Center and St Joseph Hospital, Dignity Health, Phoenix, Arizona. Electronic address:

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Utility of electrophysiologic testing for sudden death risk stratification in cardiac sarcoidosis patients with mildly impaired left ventricular function.

Respir Med 2022 01 9;191:106712. Epub 2021 Dec 9.

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1232, New York, NY, 10029, USA. Electronic address:

Background: Ventricular arrhythmias (VA) account for at least 25% of deaths caused by cardiac sarcoidosis (CS) and may arise in patients with mildly impaired LVEF (>35%).

Objective: In the current study, we examine whether EP study may be used for sudden death risk stratification in CS patients who have mildly impaired LVEF and a diagnosis of highly probable or probable CS according to the World Association of Sarcoidosis and Other Granulomatous Diseases Sarcoidosis Organ Assessment Instrument (WASOGI).

Methods: All patients: (1) exhibited a diagnosis of highly probable or probable CS according to the WASOGI, (2) exhibited cardiac MRI findings consistent with CS, (3) exhibited LVEF >45% and (4) underwent EP study. Read More

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January 2022

Predicting Wide-Dynamic Range Neuron Activity from Peripheral Nerve Stimulation using Linear Parameter Varying Models.

Annu Int Conf IEEE Eng Med Biol Soc 2021 11;2021:4428-4431

Neuromodulation treatments for chronic pain are programmed with limited knowledge of how electrical stimulation of nerve fibers affects the dynamic response of pain-processing neurons in the spinal cord and the brain. By modeling these effects with tractable representations, we may be able to improve efficacy of stimulation therapy. However, pain transmitting neurons in the dorsal horn of the spinal cord, the first pain relay station in the nervous system, have complex responses to peripheral nerve stimulation (PNS) with nonlinearities and history effects. Read More

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November 2021

Intrapericardial Delivery of APA-Microcapsules as Promising Stem Cell Therapy Carriers in an Experimental Acute Myocardial Infarction Model.

Pharmaceutics 2021 Nov 1;13(11). Epub 2021 Nov 1.

CIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain.

The administration of cardiosphere-derived cells (CDCs) after acute myocardial infarction (AMI) is very promising. CDC encapsulation in alginate-poly-l-lysine-alginate (APA) could increase cell survival and adherence. The intrapericardial (IP) approach potentially achieves high concentrations of the therapeutic agent in the infarcted area. Read More

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November 2021

Multi-locus transcranial magnetic stimulation system for electronically targeted brain stimulation.

Brain Stimul 2022 Jan-Feb;15(1):116-124. Epub 2021 Nov 21.

Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland; BioMag Laboratory, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Transcranial magnetic stimulation (TMS) allows non-invasive stimulation of the cortex. In multi-locus TMS (mTMS), the stimulating electric field (E-field) is controlled electronically without coil movement by adjusting currents in the coils of a transducer.

Objective: To develop an mTMS system that allows adjusting the location and orientation of the E-field maximum within a cortical region. Read More

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Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells.

Adv Healthc Mater 2022 04 16;11(7):e2101577. Epub 2021 Dec 16.

Department of Bioengineering, University of California Los Angeles, Los Angeles, 90095, USA.

Conductive biomaterials provide an important control for engineering neural tissues, where electrical stimulation can potentially direct neural stem/progenitor cell (NS/PC) maturation into functional neuronal networks. It is anticipated that stem cell-based therapies to repair damaged central nervous system (CNS) tissues and ex vivo, "tissue chip" models of the CNS and its pathologies will each benefit from the development of biocompatible, biodegradable, and conductive biomaterials. Here, technological advances in conductive biomaterials are reviewed over the past two decades that may facilitate the development of engineered tissues with integrated physiological and electrical functionalities. Read More

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Multisite conduction block in the epicardial substrate of Brugada syndrome.

Heart Rhythm 2022 03 1;19(3):417-426. Epub 2021 Nov 1.

Univ. Bordeaux, CRCTB U1045, Inserm, Bordeaux, France; IHU LIRYC, Electrophysiology and Heart Modeling Institute, Bordeaux, France.

Background: The Brugada pattern manifests as a spontaneous variability of the electrocardiographic marker, suggesting a variability of the underlying electrical substrate.

Objective: The purpose of this study was to investigate the response of the epicardial substrate of Brugada syndrome (BrS) to programmed ventricular stimulation and to Na blocker infusion.

Methods: We investigated 6 patients (all male; mean age 54 ± 14 years) with BrS and recurrent ventricular fibrillation. Read More

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Surgical Strategy for Directional Deep Brain Stimulation.

Neurol Med Chir (Tokyo) 2022 Jan 29;62(1):1-12. Epub 2021 Oct 29.

Department of Neurosurgery, Brain Research Institute, Niigata University.

Deep brain stimulation (DBS) is a well-established treatment for drug-resistant involuntary movements. However, the conventional quadripole cylindrical lead creates electrical fields in all directions, and the resulting spread to adjacent eloquent structures may induce unintended effects. Novel directional leads have therefore been designed to allow directional stimulation (DS). Read More

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January 2022

Neuromodulation With Thoracic Dorsal Root Ganglion Stimulation Reduces Ventricular Arrhythmogenicity.

Front Physiol 2021 7;12:713717. Epub 2021 Oct 7.

Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Sympathetic hyperactivity is strongly associated with ventricular arrhythmias and sudden cardiac death. Neuromodulation provides therapeutic options for ventricular arrhythmias by modulating cardiospinal reflexes and reducing sympathetic output at the level of the spinal cord. Dorsal root ganglion stimulation (DRGS) is a recent neuromodulatory approach; however, its role in reducing ventricular arrhythmias has not been evaluated. Read More

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October 2021

Ventricular arrhythmias in mouse models of diabetic kidney disease.

Sci Rep 2021 10 18;11(1):20570. Epub 2021 Oct 18.

Department of Medicine, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, R654, Cleveland, OH, 44109, USA.

Chronic kidney disease (CKD) affects more than 20 million people in the US, and it is associated with a significantly increased risk of sudden cardiac death (SCD). Despite the significance, the mechanistic relationship between SCD and CKD is not clear and there are few effective therapies. Using optical mapping techniques, we tested the hypothesis that mouse models of progressive diabetic kidney disease (DKD) exhibit enhanced ventricular arrhythmia incidence and underlying arrhythmia substrates. Read More

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October 2021

The cardioprotective effect of the sodium-glucose cotransporter 2 inhibitor dapagliflozin in rats with isoproterenol-induced cardiomyopathy.

Am J Transl Res 2021 15;13(9):10950-10961. Epub 2021 Sep 15.

Department of Physiology, Nanjing Medical University Nanjing 211166, Jiangsu, China.

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) has been reported to improve glycemic control. This study was designed to investigate the effects of SGLT2i dapagliflozin (dapa) on cardiomyopathy induced by isoproterenol (ISO) and its potential mechanisms. Fifty male Sprague Dawley rats were randomly assigned to the control (n=10) and the ISO (2. Read More

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September 2021

Genetic inhibition of Nuclear Factor of Activated T-cell c2 (NFATc2) prevents atrial fibrillation in CREM transgenic mice.

Cardiovasc Res 2021 Oct 14. Epub 2021 Oct 14.

Cardiovascular Research Institute.

Aims: Abnormal intracellular calcium handling contributes to the progressive nature of atrial fibrillation (AF), the most common sustained cardiac arrhythmia. Evidence in mouse models suggests that activation of the nuclear factor of activated T-cell (NFAT) signaling pathway contributes to atrial remodeling. Our aim was to determine the role of NFATc2 in AF in humans and mouse models. Read More

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October 2021