1,998 results match your criteria Programmed Electrical Stimulation


Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia.

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.

Drug-mediated or medical condition-mediated disruption of hERG function accounts for the main cause of acquired long-QT syndrome (acLQTs), which predisposes affected individuals to ventricular arrhythmias (VA) and sudden death. Many Chinese herbal medicines, especially alkaloids, have risks of arrhythmia in clinical application. The characterized mechanisms behind this adverse effect are frequently associated with inhibition of cardiac hERG channels. Read More

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Electrophysiology studies for predicting atrioventricular block in patients with syncope: A systematic review and meta-analysis.

Heart Rhythm 2021 Apr 20. Epub 2021 Apr 20.

University of Alberta, Edmonton, Alberta, Canada; Smidt Heart Institute, Cedars-Sinai Hospital, XXXX, XXXX.

Background: Syncope may be caused by intermittent complete heart block in patients with bundle branch block. Electrophysiology studies (EPSs) testing for infra-Hisian heart block are recommended by the European Society of Cardiology syncope guidelines on the basis of decades-old estimates of their negative predictive values (NPVs) for complete heart block.

Objective: The aim of this study was to determine the NPV of EPS for complete heart block in patients with syncope and bundle branch block. Read More

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Rotigaptide Infusion for the First 7 Days After Myocardial Infarction-Reperfusion Reduced Late Complexity of Myocardial Architecture of the Healing Border-Zone and Arrhythmia Inducibility.

J Am Heart Assoc 2021 May 17;10(9):e020006. Epub 2021 Apr 17.

National Heart & Lung Institute and ElectroCardioMaths Programme of the Imperial Centre for Cardiac EngineeringImperial College London London United Kingdom.

Background Survivors of myocardial infarction are at increased risk of late ventricular arrhythmias, with infarct size and scar heterogeneity being key determinants of arrhythmic risk. Gap junctions facilitate the passage of small ions and morphogenic cell signaling between myocytes. We hypothesized that gap junctions enhancement during infarction-reperfusion modulates structural and electrophysiological remodeling and reduces late arrhythmogenesis. Read More

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Balanced Intense Exercise Training Induces Atrial Oxidative Stress Counterbalanced by the Antioxidant System and Atrial Hypertrophy That Is Not Associated with Pathological Remodeling or Arrhythmogenicity.

Antioxidants (Basel) 2021 Mar 15;10(3). Epub 2021 Mar 15.

Heart and Vascular Center, Semmelweis University; Városmajor str. 68, 1122 Budapest, Hungary.

Although regular exercise training is associated with cardiovascular benefits, the increased risk of atrial arrhythmias has been observed after vigorous exercise and has been related to oxidative stress. We aimed at investigating exercise-induced atrial remodeling in a rat model of an athlete's heart and determining sex-specific differences. Age-matched young adult rats were divided into female exercised, female control, male exercised, and male control groups. Read More

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Directional Stimulation in Parkinson's Disease and Essential Tremor: The Cleveland Clinic Experience.

Neuromodulation 2021 Mar 18. Epub 2021 Mar 18.

Center For Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA.

Objective: To assess use of directional stimulation in Parkinson's disease and essential tremor patients programmed in routine clinical care.

Materials And Methods: Patients with Parkinson's disease or essential tremor implanted at Cleveland Clinic with a directional deep brain stimulation (DBS) system from November 2017 to October 2019 were included in this retrospective case series. Omnidirectional was compared against directional stimulation using therapeutic current strength, therapeutic window percentage, and total electrical energy delivered as outcome variables. Read More

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Effect of defibrillation on the performance of an implantable vagus nerve stimulation system.

Bioelectron Med 2021 Mar 16;7(1). Epub 2021 Mar 16.

LivaNova USA, Inc, 100 Cyberonics Blvd., TX, 77058, Houston, USA.

Background: Vagus Nerve Stimulation (VNS) delivers Autonomic Regulation Therapy (ART) for heart failure (HF), and has been associated with improvement in cardiac function and heart failure symptoms. VNS is delivered using an implantable pulse generator (IPG) and lead with electrodes placed around the cervical vagus nerve. Because HF patients may receive concomitant cardiac defibrillation therapy, testing was conducted to determine the effect of defibrillation (DF) on the VNS system. Read More

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Do the minimum and maximum comfortable stimulation levels influence the cortical potential latencies or the speech recognition in adult cochlear implant users?

Hear Res 2021 May 18;404:108206. Epub 2021 Feb 18.

Department of Otorhinolaryngology, University of São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, São Paulo, SP 05403-000, Brazil.

Introduction: Cochlear implants (CI) programming is based on both the measurement of the minimum levels required to stimulate the auditory nerve and the maximum levels to generate loud, yet comfortable loudness. Seeking for guidance in the adequacy of this programming, the cortical auditory evoked potentials (CAEP) have been gaining space as an important tool in the evaluation of CI users, providing information on the central auditory system.

Objective: To evaluate the influence of mishandling of electrical stimulation levels on speech processor programming on hearing thresholds, speech recognition and cortical auditory evoked potential in adult CI users. Read More

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Long-term prognosis in patients with non-type 1 Brugada electrocardiogram: Results from a large Japanese cohort of idiopathic ventricular fibrillation.

Ann Noninvasive Electrocardiol 2021 Feb 19:e12831. Epub 2021 Feb 19.

Department of Internal Medicine, Cardiovascular Division, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.

Background: Brugada syndrome (BrS) is diagnosed in patients with ST-segment elevation with spontaneous, drug-induced, or fever-induced type 1 morphology. Prognosis in type 2 or 3 Brugada electrocardiogram (Br-ECG) patients remains unknown. The purpose of this study is to evaluate long-term prognosis in non-type 1 Br-ECG patients in a large Japanese cohort of idiopathic ventricular fibrillation (The Japan Idiopathic Ventricular Fibrillation Study [J-IVFS]). Read More

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February 2021

Encapsulation and Storage of Therapeutic Fibrin-Homing Peptides using Conducting Polymer Nanoparticles for Programmed Release by Electrical Stimulation.

ACS Biomater Sci Eng 2020 04 5;6(4):2135-2145. Epub 2020 Mar 5.

Departament d'Enginyeria Quı́mica and Barcelona Research Center for Multiscale Science and Engineering, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany 10-14, 08019 Barcelona, Spain.

Cys-Arg-Glu-Lys-Ala (CREKA) is an important fibrin-homing pentapeptide that has been extensively demonstrated for diagnoses and therapies (e.g., image diagnosis of tumors and to inhibit tumor cell migration and invasion). Read More

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[Type I Brugada electrocardiographic pattern associated with Influenza B and fever. Report of a case].

Rev Med Chil 2020 Sep;148(9):1368-1370

Unidad Coronaria, Hospital Militar de Santiago, Santiago, Chile.

We report a 44-year-old male who was admitted for Influenza B and fever, presenting a type I Brugada pattern on the electrocardiogram. He evolved without cardiovascular symptoms. The pharmacological test with intravenous Procainamide reproduced type I Brugada pattern and the programmed electrical stimulation was negative for ventricular arrhythmias. Read More

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September 2020

Risk stratification in asymptomatic patients with Brugada syndrome: Utility of multiple risk factor combination rather than programmed electrical stimulation.

J Cardiovasc Electrophysiol 2021 Feb 29;32(2):507-514. Epub 2020 Dec 29.

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.

Background: The prognostic value of programmed electrical stimulation (PES) in Brugada syndrome (BrS) remains controversial. Asymptomatic BrS patients generally have a better prognosis than those with symptoms. The purpose of this study was to evaluate the value of nonaggressive PES with up to two extra stimuli and predict clinical factors for risk stratification in asymptomatic BrS patients. Read More

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February 2021

Risk and predictors of sudden death in cardiac sarcoidosis: A systematic review and meta-analysis.

Int J Cardiol 2021 Apr 23;328:130-140. Epub 2020 Nov 23.

The University of Adelaide, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia; Lyell McEwin Hospital, Adelaide, Australia. Electronic address:

Background: To evaluate the risk for ventricular arrhythmia (VA) and sudden cardiac death (SCD) in patients with cardiac sarcoidosis (CS) and determine the prognostic factors.

Methods And Results: PUBMED, EMBASE and SCOPUS were searched up to 14th April 2020. Studies reporting the incidence of SCD, appropriate ICD therapy in CS patients, or relevant prognostic information in patients having undergone MRI, PET, or programmed electrical stimulation (PES) were included. Read More

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CLOCK-BMAL1 regulates circadian oscillation of ventricular arrhythmias in failing hearts through β1 adrenergic receptor.

Am J Transl Res 2020 15;12(10):6122-6135. Epub 2020 Oct 15.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China.

The incidence of ventricular arrhythmias (VAs) in chronic heart failure (CHF) exhibits a notable circadian rhythm, for which the underlying mechanism has not yet been well defined. Thus, we aimed to investigate the role of cardiac core circadian genes on circadian VAs in CHF. First, a guinea pig CHF model was created by transaortic constriction. Read More

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October 2020

Physiological Ca Transients Versus Pathological Steady-State Ca Elevation, Who Flips the ROS Coin in Skeletal Muscle Mitochondria.

Front Physiol 2020 22;11:595800. Epub 2020 Oct 22.

Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, United States.

Mitochondria are both the primary provider of ATP and the pivotal regulator of cell death, which are essential for physiological muscle activities. Ca plays a multifaceted role in mitochondrial function. During muscle contraction, Ca influx into mitochondria activates multiple enzymes related to tricarboxylic acid (TCA) cycle and oxidative phosphorylation, resulting in increased ATP synthesis to meet the energy demand. Read More

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October 2020

Exchange protein directly activated by cAMP (Epac) mediates cardiac repolarization and arrhythmogenesis during chronic heart failure.

Can J Physiol Pharmacol 2020 Nov 11. Epub 2020 Nov 11.

Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, 74734, Nanjing, Jiangsu, China;

Most sudden cardiac death in chronic heart failure (CHF) is caused by malignant ventricular arrhythmia (VA). However, the molecular mechanism remains unclear. This study aims to explore the effect of exchange proteins directly activated by cAMP (Epac) on VA in CHF and the potential molecular mechanism. Read More

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November 2020

Seizure improvement following vagus nerve stimulator (VNS) battery change with cardiac-based seizure detection automatic stimulation (AutoStim): early experience in a regional paediatric unit.

Childs Nerv Syst 2021 Apr 10;37(4):1237-1241. Epub 2020 Nov 10.

Department of Neurosurgery, Birmingham Children's Hospital, Birmingham, B4 6NH, UK.

Purpose: The recent VNS models (AspireSR® Model 106, SenTiva™ Model 1000 (VNS Therapy®, LivaNova)) include a new function of cardiac-based seizure detection (CBSD) automatic stimulation, known as 'AutoStim'. This algorithm uses tachycardia as a proxy to a seizure, and the battery delivers a closed-loop electrical current in addition to its programmed stimulation. This function leads to further seizure reduction in adults, but this advantage has not been reported in the paediatric population. Read More

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Self-Rectifying Resistive Switching and Short-Term Memory Characteristics in Pt/HfO/TaO/TiN Artificial Synaptic Device.

Nanomaterials (Basel) 2020 Oct 29;10(11). Epub 2020 Oct 29.

Division of Electronics and Electrical Engineering, Dongguk University, Seoul 04620, Korea.

Here, we propose a Pt/HfO/TaO/TiN artificial synaptic device that is an excellent candidate for artificial synapses. First, XPS analysis is conducted to provide the dielectric (HfO/TaO/TiN) information deposited by DC sputtering and atomic layer deposition (ALD). The self-rectifying resistive switching characteristics are achieved by the asymmetric device stack, which is an advantage of the current suppression in the crossbar array structure. Read More

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October 2020

Inhibition of endoplasmic reticulum stress prevents high-fat diet mediated atrial fibrosis and fibrillation.

J Cell Mol Med 2020 12 1;24(23):13660-13668. Epub 2020 Nov 1.

Department of General Practice/VIP Medical Service, Beijing Hospital, National Center of Gerontology, Beijing, China.

Obesity is a significant risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia with increased mortality and morbidity. High-fat diet (HFD)-induced obesity is associated with the activation of endoplasmic reticulum stress (ERS). However, the role of ERS in HFD-induced AF remains elusive. Read More

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December 2020

MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals.

PLoS One 2020 30;15(10):e0241638. Epub 2020 Oct 30.

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

According to PubMed, roughly 10% of the annually added publications are describing findings from the small animal model (mice and rats), including investigations in the field of muscle physiology and training. A subset of this research requires neural stimulation with flexible adjustments of stimulation parameters, highlighting the need for reliable implantable electrical stimulators, small enough (~1 cm3), that even mice can tolerate them without impairing their movement. The MiniVStimA is a battery-powered implant for nerve stimulation with an outer diameter of 15 mm and an encapsulated volume of 1. Read More

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January 2021

Modulating the Infarcted Ventricle's Refractoriness with an Epicardial Biomaterial.

J Investig Med 2021 Feb 28;69(2):364-370. Epub 2020 Oct 28.

Sarver Heart Center, University of Arizona Arizona Health Sciences Center, Tucson, Arizona, USA.

Patients diagnosed with heart failure with reduced ejection fraction (HFrEF) are at increased risk of monomorphic ventricular tachycardia (VT) and ventricular fibrillation. The presence of myocardial fibrosis provides both anatomical and functional barriers that promote arrhythmias in these patients. Propagation of VT in a reentrant circuit depends on the presence of excitable myocardium and the refractoriness of the circuit. Read More

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February 2021

Hyaluronate supports hESC-cardiomyocyte cell therapy for cardiac regeneration after acute myocardial infarction.

Cell Prolif 2020 Dec 27;53(12):e12942. Epub 2020 Oct 27.

National Stem Cell Resource Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Introduction: Enormous progress has been made in cardiac regeneration using human embryonic stem cell-derived cardiomyocyte (hESC-CM) grafts in pre-clinical trials. However, the rate of cell survival has remained very low due to anoikis after transplantation into the heart as single cells. Numerous solutions have been proposed to improve cell survival, and one of these strategies is to co-transplant biocompatible materials or hydrogels with the hESC-CMs. Read More

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December 2020

Distributed Electric Field Induces Orientations of Nanosheets to Prepare Hydrogels with Elaborate Ordered Structures and Programmed Deformations.

Adv Mater 2020 Nov 20;32(47):e2005567. Epub 2020 Oct 20.

Ministry of Education Key Laboratory of Macromolecular, Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

Living organisms use musculatures with spatially distributed anisotropic structures to actuate deformations and locomotion with fascinating functions. Replicating such structural features in artificial materials is of great significance yet remains a big challenge. Here, a facile strategy is reported to fabricate hydrogels with elaborate ordered structures of nanosheets (NSs) oriented under a distributed electric field. Read More

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November 2020

Improved Risk Stratification of Patients With Brugada Syndrome by the New Japanese Circulation Society Guideline - A Multicenter Validation Study.

Circ J 2020 Nov 17;84(12):2158-2165. Epub 2020 Oct 17.

Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center.

Background: The new guideline (NG) published by the Japanese Circulation Society (JCS) places emphasis on previous arrhythmic syncope and inducibility of ventricular fibrillation (VF) by ≤2 extrastimuli during programmed electrical stimulation (PES) for deciding the indication of an implantable cardioverter-defibrillator in patients with Brugada syndrome (BrS). This study evaluated the usefulness of the NG and compared it with the former guideline (FG) for risk stratification of patients with BrS.Methods and Results:This was a multicenter (7 Japanese hospitals) retrospective study involving 234 patients with BrS who underwent PES at baseline (226 males; mean age at diagnosis: 44. Read More

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November 2020

Is programmed electrical stimulation mandatory for recognition of ventricular arrhythmogenicity in heart failure?

Indian J Thorac Cardiovasc Surg 2020 Jan 19;36(1):52-55. Epub 2019 Jul 19.

Narayana Hrudayalaya Institute of Medical Sciences, Bengaluru, Karnataka 560099 India.

Ischemic cardiomyopathy often presents with advanced heart failure necessitating an intensive multidisciplinary approach to management. These patients constitute a very difficult population presenting with angina and ventricular tachyarrhythmias sometimes presenting as sudden cardiac death. In those patients presenting with spontaneous ventricular tachyarrhythmias, treatment with automated intracardiac defibrillator implantation has a significant mortality benefit. Read More

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January 2020

Design and Experimental Research of Implantable Lower Esophageal Sphincter Stimulator Based on Android Bluetooth.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:5220-5223

The aim of this study is to design an implantable Lower Esophageal Sphincter (LES) stimulator connected and controlled by an Android Bluetooth for the treatment of the gastroesophageal reflux disease (GERD). Then the animal experiments are carried out to evaluate the function of the system. The LES stimulator is composed of an external controller, an Android application (APP) via a smart phone and an implantable electronic device (IED). Read More

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Electrical and structural remodeling contribute to atrial fibrillation in type 2 diabetic db/db mice.

Heart Rhythm 2021 Jan 7;18(1):118-129. Epub 2020 Sep 7.

Libin Cardiovascular Institute, Department of Cardiac Sciences, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Background: Atrial fibrillation (AF) is highly prevalent in diabetes mellitus (DM), yet the basis for this finding is poorly understood. Type 2 DM may be associated with unique patterns of atrial electrical and structural remodeling; however, this has not been investigated in detail.

Objective: The purpose of this study was to investigate AF susceptibility and atrial electrical and structural remodeling in type 2 diabetic db/db mice. Read More

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January 2021

Telemetry-controlled simultaneous stimulation-and-recording device (SRD) to study interhemispheric cortical circuits in rat primary somatosensory (SI) cortex.

BMC Biomed Eng 2019 8;1:19. Epub 2019 Aug 8.

Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building, Memphis, TN 38152 USA.

Background: A growing need exists for neuroscience platforms that can perform simultaneous chronic recording and stimulation of neural tissue in animal models in a telemetry-controlled fashion with signal processing for analysis of the chronic recording data and external triggering capability. We describe the system design, testing, evaluation, and implementation of a wireless simultaneous stimulation-and-recording device (SRD) for modulating cortical circuits in physiologically identified sites in primary somatosensory (SI) cortex in awake-behaving and freely-moving rats. The SRD was developed using low-cost electronic components and open-source software. Read More

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Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models.

Int J Mol Sci 2020 Aug 29;21(17). Epub 2020 Aug 29.

Institute of Translational Medicine, Semmelweis University, H-1094 Budapest, Hungary.

The benefits of high-fever range hyperthermia have been utilized in medicine from the Ancient Greek culture to the present day. Amplitude-modulated electro-hyperthermia, induced by a 13.56 MHz radiofrequency current (mEHT, or Oncothermia), has been an emerging means of delivering loco-regional clinical hyperthermia as a complementary of radiation-, chemo-, and molecular targeted oncotherapy. Read More

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How Should we Use Multicolumn Spinal Cord Stimulation to Optimize Back Pain Spatial Neural Targeting? A Prospective, Multicenter, Randomized, Double-Blind, Controlled Trial (ESTIMET Study).

Neuromodulation 2021 Jan 31;24(1):86-101. Epub 2020 Aug 31.

PRISMATICS Lab (Predictive Research In Spine/neurostimulation Management and Thoracic Innovation in Cardiac Surgery), Poitiers University Hospital, Poitiers, France.

Background: Recent studies have highlighted multicolumn spinal cord stimulation (SCS) efficacy, hypothesizing that optimized spatial neural targeting provided by new-generation SCS lead design or its multicolumn programming abilities could represent an opportunity to better address chronic back pain (BP).

Objective: To compare multicolumn vs. monocolumn programming on clinical outcomes of refractory postoperative chronic BP patients implanted with SCS using multicolumn surgical lead. Read More

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January 2021

Anti-Inflammatory and Antiarrhythmic Effects of Beta Blocker in a Rat Model of Rheumatoid Arthritis.

J Am Heart Assoc 2020 09 31;9(18):e016084. Epub 2020 Aug 31.

Institute of Biomedical Engineering College of Electrical and Computer Engineering National Chiao Tung University Hsinchu Taiwan.

Background Patients with rheumatoid arthritis are at twice the risk of ventricular arrhythmia and sudden cardiac death as the general population. We hypothesize that β-blocker treatment of rheumatoid arthritis is antiarrhythmic by producing synergistic anticatecholaminergic and anti-inflammatory effects. Methods and Results Collagen-induced arthritis (CIA) was induced in Lewis rats by immunization with type II collagen in Freund's incomplete adjuvant. Read More

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September 2020