1,915 results match your criteria Programmed Electrical Stimulation


Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure.

Stem Cell Res Ther 2019 Mar 7;10(1):78. Epub 2019 Mar 7.

Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Rm 1928, Block K, Hong Kong SAR, China.

Background: Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC-MSCs) in a porcine model of HF.

Methods: Eight weeks after induction of HF with myocardial infarction (MI) and rapid pacing, animals with impaired left ventricular ejection fraction (LVEF) were randomly assigned to receive direct intramyocardial injection of saline (MI group), 2 × 10 hESC-CMs (hESC-CM group), or 2 × 10 hiPSC-MSCs (hiPSC-MSC group). Read More

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http://dx.doi.org/10.1186/s13287-019-1183-3DOI Listing
March 2019
1 Read

Multispectral optoacoustic imaging of dynamic redox correlation and pathophysiological progression utilizing upconversion nanoprobes.

Nat Commun 2019 Mar 6;10(1):1087. Epub 2019 Mar 6.

Sino-Singapore International Joint Research Institute (SSIJRI), Guangzhou, 510000, China.

Precise and differential profiling of the dynamic correlations and pathophysiological implications of multiplex biological mediators with deep penetration and highly programmed precision remain critical challenges in clinics. Here we present an innovative strategy by tailoring a powerful multispectral optoacoustic tomography (MSOT) technique with a photon-upconverting nanoprobe (UCN) for simultaneous visualization of diversely endogenous redox biomarkers with excellent spatiotemporal resolution in living conditions. Upon incorporating two specific radicals-sensitive NIR cyanine fluorophores onto UCNs surface, such nanoprobes can orthogonally respond to disparate oxidative and nitrosative stimulation, and generate spectrally opposite optoacoustic signal variations, which thus achieves compelling superiorities for reversed ratiometric tracking of multiple radicals under dual independent wavelength channels, and significantly, for precise validating of their complex dynamics and correlations with redox-mediated pathophysiological procession in vivo. Read More

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http://dx.doi.org/10.1038/s41467-019-09001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403272PMC

Remotely programmed sacral neuromodulation for the treatment of patients with refractory overactive bladder: a prospective randomized controlled trial evaluating the safety and efficacy of a novel sacral neuromodulation device.

World J Urol 2019 Feb 26. Epub 2019 Feb 26.

Urology Department, Beijing Hospital, National Center of Gerontology, No. 1 DaHua Road, Dong Dan, Beijing, 100730, People's Republic of China.

Purpose: The efficacy and safety of a novel remotely programmed BetterStim sacral neuromodulation (SNM) system was evaluated in patients with refractory overactive bladder (OAB) in a prospective, controlled, multicenter trial.

Methods: A total of 84 patients referred for SNM therapy from October 2015 to January 2018 were studied. Of the patients who qualified for implantation, 37 and 33 were randomly assigned to treatment and control groups, respectively. Read More

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http://dx.doi.org/10.1007/s00345-019-02698-7DOI Listing
February 2019
2 Reads
2.666 Impact Factor

Reflections on the early invasive clinical cardiac electrophysiology era through fifty manuscripts: 1967-1992.

J Arrhythm 2019 Feb 3;35(1):7-17. Epub 2018 Dec 3.

Division of Cardiovascular Medicine University of Miami Miller School of Medicine Miami Florida.

In 1967, researchers in The Netherlands and France independently reported a new technique, later called programmed electrical stimulation. The ability to reproducibly initiate and terminate arrhythmias heralded the beginning of invasive clinical cardiac electrophysiology as a medical discipline. Over the next fifty years, insights into the pathophysiologic basis of arrhythmias would transform the field into an interventional specialty with a tremendous armamentarium of procedures. Read More

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http://dx.doi.org/10.1002/joa3.12143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373646PMC
February 2019

Upregulation of MMP-9 and CaMKII prompts cardiac electrophysiological changes that predispose denervated transplanted hearts to arrhythmogenesis after prolonged cold ischemic storage.

Biomed Pharmacother 2019 Feb 20;112:108641. Epub 2019 Feb 20.

Department of Anaesthesiology, Guizhou Medical University, Guiyang, China.

Background: Although the importance of the potential mechanisms of arrhythmogenesis, including cardiac electrophysiology dysfunction and gap junction electrical uncoupling by Cx43 degradation under pathological conditions, has been widely and thoroughly established, the correlations between these mechanisms and biomarkers of cold ischemic insult have not yet been confirmed. Limited evidence suggests that these biomarkers are significantly associated with cardiac dysrhythmia. Thus, in this study, we analyzed such correlations in denervated transplanted hearts. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108641DOI Listing
February 2019
1 Read

Importance of the vein of Marshall involvement in mitral isthmus ablation.

Pacing Clin Electrophysiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Background: Epicardiac conduction via the vein of Marshall (VOM) can bypass the mitral isthmus (MI) line, making MI ablation difficult. This study aimed to assess the contribution of the VOM in achieving MI conduction block.

Methods: This study included 143 consecutive patients with non-paroxysmal atrial fibrillation who underwent initial MI ablation. Read More

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http://dx.doi.org/10.1111/pace.13640DOI Listing
February 2019
3 Reads

Restoration of upper-limb function after chronic severe hemiplegia: A case report on the feasibility of a brain-computer interface controlled functional electrical stimulation therapy.

Am J Phys Med Rehabil 2019 Feb 13. Epub 2019 Feb 13.

Toronto Rehabilitation Institute - University Health Network.

Functional electrical stimulation therapy (FEST) is a state-of-the-art treatment for retraining motor function following neurological injuries. Recent literature suggests that FEST can be further improved with brain-computer interface (BCI) technology. In this case study, we assessed the feasibility of using BCI-triggered FEST (BCI-FEST) to restore upper-limb function in a 57-year old male with severe left hemiplegia resulting from a stroke six years prior to enrollment in the study. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001163DOI Listing
February 2019
1 Read

Bipolar active fixation left ventricular lead or quadripolar passive fixation lead? An Italian multicenter experience.

J Cardiovasc Med (Hagerstown) 2019 Apr;20(4):192-200

Azienda Ospedaliera Universitaria S. Orsola-Malpighi, Bologna.

Aims: About one-third of patients receiving cardiac resynchronization therapy (CRT) are not responders, due to either patient selection or technical issues. Left ventricular quadripolar passive fixation leads (QPL) and bipolar active fixation (BAF) leads have been designed to ensure a targeted left ventricular stimulation area, minimizing lead dislodgments and phrenic nerve stimulation (PNS). The aim was to compare real-world safety and efficacy of BAF (Attain Stability, Medtronic Plc. Read More

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http://Insights.ovid.com/crossref?an=01244665-201904000-0000
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http://dx.doi.org/10.2459/JCM.0000000000000778DOI Listing
April 2019
3 Reads

Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368.

BMC Anesthesiol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

Background: Reperfusion ventricular arrhythmia (RA) associated with hypothermic ischaemic storage is increasingly recognized as a substantial contributor to adverse consequences after heart transplantation. Ischemia- or hypothermia-induced gap junction (GJ) remodelling is closely linked to RA. Reducing GJ remodelling contributes to RA attenuation and is important in heart transplantation. Read More

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http://dx.doi.org/10.1186/s12871-018-0656-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325883PMC
January 2019
2 Reads
1.333 Impact Factor

Computational Study of the Effect of Electrode Polarity on Neural Activation Related to Paresthesia Coverage in Spinal Cord Stimulation Therapy.

Neuromodulation 2018 Dec 26. Epub 2018 Dec 26.

Center of Research and Innovation in Bioengineering, Universitat Politècnica de València, Valencia, Spain.

Objective: Using computer simulation, we investigated the effect of electrode polarity on neural activation in spinal cord stimulation and propose a new strategy to maximize the activating area in the dorsal column (DC) and, thus, paresthesia coverage in clinical practice.

Materials And Methods: A new three-dimensional spinal cord model at the T10 vertebral level was developed to simulate neural activation induced by the electric field distribution produced by different typical four-contact electrode polarities in single- and dual-lead stimulation. Our approach consisted of the combination of a finite element model of the spinal cord developed in COMSOL Multiphysics and a nerve fiber model implemented in MATLAB. Read More

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http://dx.doi.org/10.1111/ner.12909DOI Listing
December 2018

Prevalence of spontaneous type I ECG pattern, syncope, and other risk markers in sudden cardiac arrest survivors with Brugada syndrome.

Pacing Clin Electrophysiol 2019 Feb 6;42(2):257-264. Epub 2019 Jan 6.

Imperial College Healthcare NHS Trust, London, UK.

Introduction: A spontaneous type I electrocardiogram (ECG) pattern and/or unheralded syncope are conventionally used as risk markers for primary prevention of sudden cardiac arrest/death (SCA/SCD) in Brugada syndrome (BrS). In this study, we determine the prevalence of conventional and newer markers of risk in those with and without previous aborted SCA events.

Methods: All patients with BrS were identified at our institute. Read More

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http://dx.doi.org/10.1111/pace.13587DOI Listing
February 2019
3 Reads

Electroanatomic and Pathologic Right Ventricular Outflow Tract Abnormalities in Patients With Brugada Syndrome.

J Am Coll Cardiol 2018 Dec;72(22):2747-2757

Cardiovascular Department, San Donato Hospital, Arezzo, Italy.

Background: The prevalence and significance of structural abnormalities in Brugada syndrome (BrS) are still largely debated.

Objectives: The authors investigated the relationship between genetic background, electroanatomic abnormalities, and pathologic substrate in BrS.

Methods: They performed 3-dimensional electroanatomic unipolar and bipolar mapping in 30 patients with BrS. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.09.037DOI Listing
December 2018
5 Reads

Targeted regulation of sympathetic activity in paraventricular nucleus reduces inducible ventricular arrhythmias in rats after myocardial infarction.

J Cardiol 2019 Jan 4;73(1):81-88. Epub 2018 Jul 4.

Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China. Electronic address:

Background: The hypothalamic paraventricular nucleus (PVN) is the center of the regulation of autonomic nervous system functions and cardiovascular activity. Phosphoinositide-3 kinase (PI3K)-AKT pathway in PVN contributes to mediate sympathetic nerve activity and is activated in spontaneously hypertensive rats. Overactivation of the sympathetic output was considered as an important mechanism of the arrhythmias. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.06.003DOI Listing
January 2019
5 Reads
2.566 Impact Factor

Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat.

J Cell Mol Med 2019 Jan 24;23(1):112-125. Epub 2018 Oct 24.

School of Medicine, Shandong University, Jinan, China.

Malignant ventricular arrhythmias (VAs) following myocardial infarction (MI) is a lethal complication resulting from sympathetic nerve hyperactivity. Numerous evidence have shown that inflammation within the paraventricular nucleus (PVN) participates in sympathetic hyperactivity. Our aim was to explore the role of Macrophage-inducible C-type lectin (Mincle) within the PVN in augmenting sympathetic activity following MI,and whether NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome/IL-1β axis is involved in this activity. Read More

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http://doi.wiley.com/10.1111/jcmm.13890
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http://dx.doi.org/10.1111/jcmm.13890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307841PMC
January 2019
13 Reads

Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure.

Drug Des Devel Ther 2018 10;12:3407-3418. Epub 2018 Oct 10.

Heart Center, Guangdong Provincial Hospital of Chinese Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China,

Purpose: Shensong Yangxin (SSYX) capsule is a traditional Chinese medicine that has been used widely to treat cardiac arrhythmia. This study aimed to assess whether SSYX prevents atrial fibrillation (AF) after chronic myocardial infarction (MI)-induced heart failure and to determine the underlying mechanisms.

Materials And Methods: The study included 45 male Sprague Dawley rats. Read More

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http://dx.doi.org/10.2147/DDDT.S182834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186904PMC
October 2018
2 Reads

Reverse electrical remodeling in rats with heart failure and preserved ejection fraction.

JCI Insight 2018 Oct 4;3(19). Epub 2018 Oct 4.

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Sudden death is the most common mode of exodus in patients with heart failure and preserved ejection fraction (HFpEF). Cardiosphere-derived cells (CDCs) reduce inflammation and fibrosis in a rat model of HFpEF, improving diastolic function and prolonging survival. We tested the hypothesis that CDCs decrease ventricular arrhythmias (VAs) and thereby possibly contribute to prolonged survival. Read More

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https://insight.jci.org/articles/view/121123
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http://dx.doi.org/10.1172/jci.insight.121123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237473PMC
October 2018
7 Reads

Medium-term Electrophysiologic Effects of a Cellularized Scaffold Implanted in Rats After Myocardial Infarction.

Cureus 2018 Jul 10;10(7):e2959. Epub 2018 Jul 10.

Division of Biomedical Research, Institute of Molecular Biology and Biotechnology - Forth, Ioannina, GRC.

Background Cardiac repair strategies are being evaluated for myocardial infarctions, but the safety issues regarding their arrhythmogenic potential remain unresolved. By utilizing the in-vivo rat model, we have examined the medium-term electrophysiologic effects of a biomaterial scaffold that has been cellularized with spheroids of human adipose tissue, derived from mesenchymal stem cells and umbilical vein endothelial cells. Methods Mesenchymal stem cells, which exhibit adequate differentiation capacity, were co-cultured with umbilical vein endothelial cells and were seeded on an alginate based scaffold. Read More

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http://dx.doi.org/10.7759/cureus.2959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132679PMC
July 2018
4 Reads

Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats.

Comput Biol Med 2018 Nov 16;102:390-395. Epub 2018 Aug 16.

Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan.

Chronic hypertension is a multifactorial disease that is highly associated with cardiovascular disorders. Physical activity, such as long-term exercise, is advocated as a treatment for hypertension, but the responses of different age groups to long-term exercise are unknown. We used aged spontaneous hypertensive rats (SHRs, 80 weeks old) to test the hypothesis that long-term exercise compensated for deficient autonomic control and reduced susceptibility to ventricular tachycardia (VT) and ventricular fibrillation (VF) in this animal model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825183023
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http://dx.doi.org/10.1016/j.compbiomed.2018.08.016DOI Listing
November 2018
10 Reads

A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias.

PLoS One 2018 22;13(8):e0201910. Epub 2018 Aug 22.

Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany.

Background: Electrophysiological studies in mice, the prevailing model organism in the field of basic cardiovascular research, are impeded by the low yield of programmed electrical stimulation (PES).

Objective: To investigate a modified approach for ventricular arrhythmia (VA) induction and a novel scoring system in mice.

Method: A systematic review of literature on current methods for PES in mice searching the PubMed database revealed that VA inducibility was low and ranged widely (4. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201910PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104969PMC
February 2019
3 Reads

Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers.

J Pharmacol Sci 2018 Aug 4;137(4):372-378. Epub 2018 Aug 4.

Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. Electronic address:

We examined electrophysiological indices of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) sheets in order to quantitatively estimate Na, K and Ca channel blocking actions of bepridil and amiodarone using microelectrode array system in comparison with that of E-4031. We analyzed the field potential duration, effective refractory period, current threshold and conduction property using a programmed electrical stimulation protocol to obtain the post repolarization refractoriness and coefficient a of the relationship between the pacing cycle length and field potential duration. Electropharmacological profile of each drug was successfully characterized; namely, 1) the changes in the current threshold and conduction property provided basic information of Na channel blocking kinetics, 2) the relationship between pacing cycle length and field potential duration reflected drug-induced inhibition of human ether-à-go-go-related gene (hERG) K channel, 3) the post repolarization refractoriness indicated the relative contribution of these drugs to Na and K channel blockade, and 4) L-type Ca channel blocking action was more obvious in the field potential waveform of the hiPSC-CMs sheets than that expected in the electrocardiogram in humans. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.07.011DOI Listing
August 2018
2 Reads

Variation in activation time during bipolar vs extended bipolar left ventricular pacing.

J Cardiovasc Electrophysiol 2018 Dec 5;29(12):1675-1681. Epub 2018 Oct 5.

Department of Imaging Sciences and Biomedical Engineering, King's College London, London, UK.

Background: Cardiac resynchronization therapy (CRT) is typically delivered via quadripolar leads that allow stimulation using either true bipolar pacing, where stimulation occurs between two electrodes (BP) on the quadripolar lead, or extended bipole (EBP) left ventricular (LV) pacing, with the quadripolar electrodes and right ventricular coil acting as the cathode and anode, respectively. True bipolar pacing is associated with reductions in mortality and it has been postulated that these differences are the result of enhanced electrical activation.

Materials And Methods: Patients undergoing a CRT underwent an electrocardiographic imaging study where electrical activation data were recorded while different LV pacing vectors were temporarily programmed. Read More

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http://dx.doi.org/10.1111/jce.13714DOI Listing
December 2018
10 Reads

Unanesthetized Rodents Demonstrate Insensitivity of QT Interval and Ventricular Refractory Period to Pacing Cycle Length.

Front Physiol 2018 11;9:897. Epub 2018 Jul 11.

Cardiac Arrhythmia Research Laboratory, Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

The cardiac electrophysiology of mice and rats has been analyzed extensively, often in the context of pathological manipulations. However, the effects of beating rate on the basic electrical properties of the rodent heart remain unclear. Due to technical challenges, reported electrophysiological studies in rodents are mainly from preparations or under deep anesthesia, conditions that might be quite far from the normal physiological state. Read More

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http://dx.doi.org/10.3389/fphys.2018.00897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050393PMC
July 2018
6 Reads

Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction.

Sci Rep 2018 Jul 5;8(1):10206. Epub 2018 Jul 5.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Ventricular arrhythmias (VAs) are the leading cause of sudden cardiac death in patients with myocardial infarction (MI). We sought to compare effects of renal denervation (RDN) and metoprolol on VAs after MI. Fifty-four male Sprague-Dawley rats underwent ligation of left anterior descending coronary artery to induce MI, while 6 rats served as Control. Read More

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http://dx.doi.org/10.1038/s41598-018-28562-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033884PMC
July 2018
3 Reads

Afterdepolarizations and triggered activity as a mechanism for clinical arrhythmias.

Authors:
Andrew L Wit

Pacing Clin Electrophysiol 2018 Jun 19. Epub 2018 Jun 19.

Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York City, NY, USA.

Afterdepolarizations cause triggered arrhythmias. One kind occurs after repolarization is complete, delayed afterdepolarizations (DADs). Another occurs as an interruption in repolarization, early afterdepolarizations (EADs). Read More

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http://dx.doi.org/10.1111/pace.13419DOI Listing
June 2018
3 Reads

Assessment of small fibers using evoked potentials.

Scand J Pain 2014 Apr 1;5(2):111-118. Epub 2014 Apr 1.

Department of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim (CBTM), Heidelberg University, Mannheim, Germany.

Background and purpose Conventional neurophysiological techniques do not assess the function of nociceptive pathways and are inadequate to detect abnormalities in patients with small-fiber damage. This overview aims to give an update on the methods and techniques used to assess small fiber (Aδ- and C-fibers) function using evoked potentials in research and clinical settings. Methods Noxious radiant or contact heat allows the recording of heat-evoked brain potentials commonly referred to as laser evoked potentials (LEPs) and contact heat-evoked potentials (CHEPs). Read More

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http://dx.doi.org/10.1016/j.sjpain.2013.11.007DOI Listing
April 2014
21 Reads

Pregnancy and oestrogen regulate sinoatrial node calcium homeostasis and accelerate pacemaking.

Cardiovasc Res 2018 Oct;114(12):1605-1616

Montreal Heart Institute, Research Center, 5000 Bélanger, Montréal, Québec, Canada.

Aims: During pregnancy, there is a significant increase in heart rate (HR) potentially associated with an increased risk of arrhythmias or exacerbation of pre-existing cardiac conditions endangering both mother and foetus. Calcium homeostasis plays an important role in regulating automaticity of the sinoatrial node (SAN); however, its contribution to the accelerated HR during pregnancy remains unknown.

Methods And Results: Using murine SAN cells, we showed that pregnancy increased L-type Ca2+ current (ICaL) and CaV1. Read More

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http://dx.doi.org/10.1093/cvr/cvy129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148331PMC
October 2018
10 Reads

Preexcitation syndrome: experimental study on the electrocardiogram of antegradely conducting accessory pathway.

BMC Cardiovasc Disord 2018 05 21;18(1):100. Epub 2018 May 21.

Department of Respiration Medicine of the First Affiliated Hospital of Jinzhou Medical University, Renmin Street, Jinzhou, 121000, Liaoning Province, China.

Background: Preexcitation syndrome is characterized by a dominant delta wave on the baseline electrocardiogram (ECG), resulting from the change in QRS initial vector by the accessory pathway (AP). This study is to explore the effect of ventricular preexcitation on the QRS initial, maximal and terminal vector in an experimental rabbit with preexcitation syndrome induced by programmed electrical stimulation.

Methods: Rabbits (n = 10) were randomized for the experimental model of ventricular preexcitation. Read More

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http://dx.doi.org/10.1186/s12872-018-0836-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963063PMC
May 2018
5 Reads

Long-Term Outcomes of Catheter Ablation of Electrical Storm in Nonischemic Dilated Cardiomyopathy Compared With Ischemic Cardiomyopathy.

JACC Clin Electrophysiol 2017 Jul 26;3(7):767-778. Epub 2017 Apr 26.

Cardiac Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Objectives: The goal of this study was to determine the long-term outcomes of catheter ablation (CA) of electrical storm in patients with nonischemic dilated cardiomyopathy (NIDCM) compared with patients with ischemic cardiomyopathy (ICM).

Background: CA of ventricular tachycardia (VT) electrical storm has been shown to improve VT-free survival in patients with ICM. Data on the outcomes of CA of electrical storm in patients with NIDCM are insufficient. Read More

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http://dx.doi.org/10.1016/j.jacep.2017.01.020DOI Listing
July 2017
28 Reads

Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy.

Cell Physiol Biochem 2018 5;46(6):2471-2479. Epub 2018 May 5.

Background/aims: To investigate the impact of renal denervation (RDN) on myocardial fibrosis and ventricular arrhythmias (VAs) in rats with ischemic cardiomyopathy.

Methods: An ischemic cardiomyopathy model was reproduced with myocardial infarction (MI) in adult Sprague-Dawley male rats. The RDN/Sham-RDN procedure was performed at 2 weeks after MI. Read More

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http://dx.doi.org/10.1159/000489653DOI Listing
August 2018
3 Reads

Nanopulse Stimulation (NPS) Induces Tumor Ablation and Immunity in Orthotopic 4T1 Mouse Breast Cancer: A Review.

Cancers (Basel) 2018 Mar 30;10(4). Epub 2018 Mar 30.

Frank Reidy Research Center for Bioelectrics, 4211 Monarch Ways, Suite 300, Norfolk, VA 23508, USA.

Nanopulse Stimulation (NPS) eliminates mouse and rat tumor types in several different animal models. NPS induces protective, vaccine-like effects after ablation of orthotopic rat N1-S1 hepatocellular carcinoma. Here we review some general concepts of NPS in the context of studies with mouse metastatic 4T1 mammary cancer showing that the postablation, vaccine-like effect is initiated by dynamic, multilayered immune mechanisms. Read More

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http://dx.doi.org/10.3390/cancers10040097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923352PMC
March 2018
6 Reads

A Dynamically Focusing Cochlear Implant Strategy Can Improve Vowel Identification in Noise.

Ear Hear 2018 Nov/Dec;39(6):1136-1145

Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.

Objectives: The standard, monopolar (MP) electrode configuration used in commercially available cochlear implants (CI) creates a broad electrical field, which can lead to unwanted channel interactions. Use of more focused configurations, such as tripolar and phased array, has led to mixed results for improving speech understanding. The purpose of the present study was to assess the efficacy of a physiologically inspired configuration called dynamic focusing, using focused tripolar stimulation at low levels and less focused stimulation at high levels. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129442PMC
November 2019
6 Reads

From the basic science of biological effects of ultrashort electrical pulses to medical therapies.

Bioelectromagnetics 2018 May 12;39(4):257-276. Epub 2018 Mar 12.

Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia.

This article is based on my presentation at the D'Arsonval Ceremony at the Joint Annual Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association in Hangzhou, China, in June of 2017. It describes the pathway from the first studies on the effects of intense, nanosecond pulses on biological cells to the development of medical therapies based on these effects. The motivation for the initial studies of the effects of high voltage, nanosecond pulses on mammalian cells was based on a simple electrical circuit model, which predicted that such pulses allow us to affect not just the plasma membrane but also the subcellular structures. Read More

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http://dx.doi.org/10.1002/bem.22117DOI Listing
May 2018
9 Reads

Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure.

Biomed Pharmacother 2018 Apr 8;100:156-167. Epub 2018 Feb 8.

Heart Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510006, PR China. Electronic address:

Objective: The study aimed to investigate whether a Shengmai San-derived herbal, Fumai granule (FM), which had a preventive effect on atrial fibrillation (AF) in myocardial infarction (MI)-induced heart failure (HF) rat and to determine the underlying mechanisms.

Design And Methods: MI was induced by a ligation of the left anterior descending coronary artery. One week after MI surgery, FM was gavaged for 4 weeks. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.02.013DOI Listing
April 2018
1 Read

Atrial arrhythmias and autonomic dysfunction in rats exposed to chronic intermittent hypoxia.

Am J Physiol Heart Circ Physiol 2018 06 9;314(6):H1160-H1168. Epub 2018 Feb 9.

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario , London, Ontario , Canada.

Obstructive sleep apnea, which involves chronic intermittent hypoxia (CIH), is a major risk factor for developing atrial fibrillation (AF). Whether or not CIH alone alters cardiac mechanisms to support AF is unknown. This study investigated the effects of CIH on atrial electrophysiology and arrhythmia vulnerability and evaluated the role of autonomics in CIH promotion of AF. Read More

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http://dx.doi.org/10.1152/ajpheart.00173.2017DOI Listing
June 2018
7 Reads

Risk Stratification for Sudden Cardiac Death After Myocardial Infarction.

Annu Rev Med 2018 Jan;69:147-164

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.

Sudden cardiac death (SCD) accounts for ∼50% of mortality after myocardial infarction (MI). Most SCDs result from ventricular tachyarrhythmias, and the tachycardias that precipitate cardiac arrest result from multiple mechanisms. As a result, it is highly unlikely that any single test will identify all patients at risk for SCD. Read More

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http://dx.doi.org/10.1146/annurev-med-041316-090046DOI Listing
January 2018
10 Reads

Was a mistake made when programmed electrical stimulation was eliminated as a sudden death risk marker in hypertrophic cardiomyopathy?

Int J Cardiol 2018 03 28;254:238-239. Epub 2018 Jan 28.

Johns Hopkins Heart and Vascular Institute, The Johns Hopkins Hospital, 600 N Wolfe St., Sheikh Zayad Tower, 7125R, Baltimore, MD 21287, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.12.019DOI Listing
March 2018
3 Reads

Programmed electrical stimulation-guided encircling cryoablation concomitant to surgical ventricular reconstruction for primary prevention of ventricular arrhythmias.

Eur J Cardiothorac Surg 2018 07;54(1):98-105

Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.

Objectives: Surgical ventricular reconstruction (SVR) is an effective treatment to improve left ventricular (LV) function in patients with ischaemic heart failure and an LV anterior-apical aneurysm. Ventricular arrhythmia (VA) is an important cause for morbidity and mortality in these patients. Therefore, encircling cryoablation targeting the VA substrate may be required. Read More

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https://academic.oup.com/ejcts/article/54/1/98/4819228
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http://dx.doi.org/10.1093/ejcts/ezx496DOI Listing
July 2018
14 Reads

Reduced N-Type Ca Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis.

J Am Heart Assoc 2018 Jan 15;7(2). Epub 2018 Jan 15.

Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE

Background: Attenuated cardiac vagal activity is associated with ventricular arrhythmogenesis and related mortality in patients with chronic heart failure. Our recent study has shown that expression of N-type Ca channel α-subunits (Ca2.2-α) and N-type Ca currents are reduced in intracardiac ganglion neurons from rats with chronic heart failure. Read More

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http://dx.doi.org/10.1161/JAHA.117.007457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850164PMC
January 2018
18 Reads

Nano-Pulse Stimulation induces immunogenic cell death in human papillomavirus-transformed tumors and initiates an adaptive immune response.

PLoS One 2018 11;13(1):e0191311. Epub 2018 Jan 11.

Department of Molecular Microbiology & Immunology, University of Southern California, Los Angeles, CA, United States of America.

Nano-Pulse Stimulation (NPS) is a non-thermal pulsed electric field modality that has been shown to have cancer therapeutic effects. Here we applied NPS treatment to the human papillomavirus type 16 (HPV 16)-transformed C3.43 mouse tumor cell model and showed that it is effective at eliminating primary tumors through the induction of immunogenic cell death while subsequently increasing the number of tumor-infiltrating lymphocytes within the tumor microenvironment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191311PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764415PMC
February 2018
8 Reads

Implantable, wireless device platforms for neuroscience research.

Curr Opin Neurobiol 2018 06 27;50:42-49. Epub 2017 Dec 27.

Departments of Materials Science and Engineering, Biomedical Engineering, Chemistry, Neurological Surgery, Mechanical Engineering, Electrical Engineering and Computer Science, Simpson Querrey Institute & Feinberg Medical School, 2145 Sheridan Road, Evanston, IL 60208, United States. Electronic address:

Recently developed classes of ultraminiaturized wireless devices provide powerful capabilities in neuroscience research, as implantable light sources for simulation/inhibition via optogenetics, as integrated microfluidic systems for programmed pharmacological delivery and as multimodal sensors for physiological measurements. These platforms leverage basic advances in biocompatible materials, semiconductor device designs and systems engineering concepts to afford modes of operation that are qualitatively distinct from those of conventional approaches that tether animals to external hardware by means of optical fibers, electrical cables and/or fluidic tubing. Neuroscience studies that exploit the unique features of these technologies enable insights into neural function through targeted stimulation, inhibition and recording, with spatially and genetically precise manipulation of neural circuit activity. Read More

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http://dx.doi.org/10.1016/j.conb.2017.12.007DOI Listing
June 2018
6 Reads

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration.

Adv Drug Deliv Rev 2018 Apr 17;129:148-168. Epub 2017 Dec 17.

School of Materials, The University of Manchester, Manchester M13 9PL, UK. Electronic address:

Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment. Read More

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http://dx.doi.org/10.1016/j.addr.2017.12.012DOI Listing
April 2018
10 Reads

Selecting electrode configurations for image-guided cochlear implant programming using template matching.

J Med Imaging (Bellingham) 2018 Apr 11;5(2):021202. Epub 2017 Dec 11.

Vanderbilt University, Department of Electrical Engineering and Computer Science, Nashville, Tennessee, United States.

Cochlear implants (CIs) are neural prostheses that restore hearing using an electrode array implanted in the cochlea. After implantation, the CI processor is programmed by an audiologist. One factor that negatively impacts outcomes and can be addressed by programming is cross-electrode neural stimulation overlap (NSO). Read More

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http://dx.doi.org/10.1117/1.JMI.5.2.021202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724566PMC
April 2018
5 Reads

Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes.

J Neural Eng 2018 Apr;15(2):026005

Department of Bioengineering, University of Utah, Salt Lake City, UT, United States of America. Scientific Computing & Imaging (SCI) Institute, University of Utah, Salt Lake City, UT, United States of America.

Objective: Deep brain stimulation (DBS) is a growing treatment option for movement and psychiatric disorders. As DBS technology moves toward directional leads with increased numbers of smaller electrode contacts, trial-and-error methods of manual DBS programming are becoming too time-consuming for clinical feasibility. We propose an algorithm to automate DBS programming in near real-time for a wide range of DBS lead designs. Read More

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http://dx.doi.org/10.1088/1741-2552/aaa14bDOI Listing
April 2018
4 Reads

Telmisartan reduces arrhythmias through increasing cardiac connexin43 by inhibiting IL-17 after myocardial infarction in rats.

Authors:
H-Y Chang X Li Y Tian

Eur Rev Med Pharmacol Sci 2017 Nov;21(22):5283-5289

Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, Harbin, China.

Objective: To observe the expressions of myocardial connexin43 (Cx43) and interleukin-17 (IL-17) in acute myocardial infarction (AMI) rats and investigate its possible mechanism of telmisartan in the prevention and treatment of arrhythmia in AMI.

Materials And Methods: Sprague Dawley (SD) rats were selected and myocardial infarction model was established. After the successful modeling, the rats were randomly divided into three groups: Sham group, MI group, Telm group. Read More

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http://dx.doi.org/10.26355/eurrev_201711_13853DOI Listing
November 2017
9 Reads

Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation.

BMC Cardiovasc Disord 2017 Dec 8;17(1):289. Epub 2017 Dec 8.

Arrhythmia Clinic, Skåne University Hospital and Department of Cardiology, Clinical Sciences, Lund University, 21185, Lund, Sweden.

Background: Atrial fibrillatory cycle length has been considered one of the indices of atrial electrical remodelling during atrial fibrillation (AF), which can be assessed from surface ECG by computer-assisted calculation of atrial fibrillatory rate (AFR). Horses have been suggested as a bona fide model for AF studies since horses too, develop lone AF, however data on AF characteristics in horses are extremely sparse and non-invasive characterization of AF complexity using surface ECG processing has not been reported.

Aim: The aim was to study characteristics of induced AF and its modification by flecainide. Read More

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http://dx.doi.org/10.1186/s12872-017-0720-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723027PMC
December 2017
10 Reads

Tpeak-Tend interval during therapeutic hypothermia can predict upcoming ventricular fibrillation in subjects with aborted arrhythmic sudden cardiac death: 3-years follow-up results.

Europace 2017 Dec;19(suppl_4):iv17-iv24

The Heart Center of Chonnam National University Hospital, 42 Jaebongro, Dong-gu, Gwangju 61469, South Korea.

Aims: Prolonged Tpeak-Tend interval has been shown to be markers of arrhythmogenesis in various cardiac disorders. However, its dynamicity is one of the obstacles to predict fatal ventricular arrhythmia. This study investigated whether Tpeak-Tend interval during therapeutic hypothermia (TH) is associated with ventricular fibrillation (VF) inducibility and clinical arrhythmia in subjects with aborted arrhythmic sudden cardiac death (SCD). Read More

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http://dx.doi.org/10.1093/europace/eux281DOI Listing
December 2017
39 Reads

Human eye-inspired soft optoelectronic device using high-density MoS-graphene curved image sensor array.

Nat Commun 2017 11 21;8(1):1664. Epub 2017 Nov 21.

Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.

Soft bioelectronic devices provide new opportunities for next-generation implantable devices owing to their soft mechanical nature that leads to minimal tissue damages and immune responses. However, a soft form of the implantable optoelectronic device for optical sensing and retinal stimulation has not been developed yet because of the bulkiness and rigidity of conventional imaging modules and their composing materials. Here, we describe a high-density and hemispherically curved image sensor array that leverages the atomically thin MoS-graphene heterostructure and strain-releasing device designs. Read More

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http://www.nature.com/articles/s41467-017-01824-6
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http://dx.doi.org/10.1038/s41467-017-01824-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698290PMC
November 2017
31 Reads

Electrical and mechanical alternans during ventricular tachycardia with moderate chronic heart failure.

J Electrocardiol 2018 Jan - Feb;51(1):33-37. Epub 2017 Sep 23.

Sarver Heart Center, University of Arizona, Tucson, AZ, United States. Electronic address:

A chronic heart failure (CHF) rat underwent epicardial programmed electrical stimulation (PES). Ventricular tachycardia (VT) developed during PES. Mechanical alternans was noted despite fixed tachycardia cycle length. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2017.09.002DOI Listing
February 2019
11 Reads
1.363 Impact Factor

Systematic review for the 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.

Heart Rhythm 2018 10 4;15(10):e253-e274. Epub 2017 Nov 4.

Background: Although large randomized clinical trials have found that primary prevention use of an implantable cardioverter-defibrillator (ICD) improves survival in patients with cardiomyopathy and heart failure symptoms, patients who receive ICDs in practice are often older and have more comorbidities than patients who were enrolled in the clinical trials. In addition, there is a debate among clinicians on the usefulness of electrophysiological study for risk stratification of asymptomatic patients with Brugada syndrome.

Aim: Our analysis has 2 objectives. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15475271173125
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http://dx.doi.org/10.1016/j.hrthm.2017.10.037DOI Listing
October 2018
37 Reads