4,382 results match your criteria Proctitis


Cytomegalovirus Proctitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy: A Case Report.

Cureus 2020 Apr 26;12(4):e7837. Epub 2020 Apr 26.

Gastroenterology, University of Illinois College of Medicine at Peoria - OSF Saint Francis Medical Center, Peoria, USA.

Ibrutinib is a Bruton tyrosine kinase (BTK) inhibitor that has shown significant efficacy in patients with lymphoid carcinomas, mostly chronic lymphocytic leukemia (CLL). Cytomegalovirus (CMV) infection is not a common infectious complication associated with ibrutinib. To increase the clinical awareness about this rare entity, we present the first case of CMV proctitis in an immunocompromised host who was being treated with ibrutinib. Read More

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http://dx.doi.org/10.7759/cureus.7837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250520PMC

Remission of ulcerative colitis flare-up induced by nivolumab.

Int J Colorectal Dis 2020 May 26. Epub 2020 May 26.

Division of Urology, Department of Urology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.

Background: Immune checkpoint inhibitors (ICIs) have been used to treat many cancers, but ICIs are rarely administered for malignant tumours coexisting with inflammatory bowel disease.

Methods And Results: We report a 77-year-old man experiencing an ulcerative colitis (UC) flare-up after receiving nivolumab as third-line therapy for multiple metastases of renal cell carcinoma. Mild UC (proctitis form) had been diagnosed at age 59 years and remission was maintained for 17 years with only a low dose of 5-ASA. Read More

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http://dx.doi.org/10.1007/s00384-020-03638-3DOI Listing

Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification.

World J Gastrointest Pathophysiol 2020 May;11(3):64-77

Laboratory of Molecular Microbiology, Biology Department, Universitat de Girona, Girona 17003, Spain.

Background: The challenges for inflammatory bowel disease (IBD) diagnostics are to discriminate it from gut conditions with similar symptoms such as irritable bowel syndrome (IBS), to distinguish IBD subtypes, to predict disease progression, and to establish the risk to develop colorectal cancer (CRC). Alterations in gut microbiota have been proposed as a source of information to assist in IBD diagnostics. (), its phylogroups, and () have been reported as potential biomarkers, but their performance in challenging IBD diagnostic situations remains elusive. Read More

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http://dx.doi.org/10.4291/wjgp.v11.i3.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226914PMC

Acute organ toxicity correlates with better clinical outcome after chemoradiotherapy in patients with anal carcinoma.

Radiother Oncol 2020 May 14;149:168-173. Epub 2020 May 14.

Department of Radiotherapy and Oncology, University Hospital, Goethe University, Frankfurt, Germany; Frankfurt Cancer Institute (FCI), Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), partner site, Frankfurt a. M., Germany. Electronic address:

Background And Purpose: Previous studies have shown that acute organ toxicity to (chemo)radiotherapy (CRT) is associated with improved oncological outcome in various tumor types. The aim of the present study was to investigate the relationship of toxicity with clinical outcome in a large cohort of 223 patients with anal squamous cell carcinoma (ASCC) treated with standard CRT.

Materials And Methods: We identified 223 patients treated with definitive CRT for non-metastasized ASCC. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.05.016DOI Listing
May 2020
4.363 Impact Factor

Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients.

BMC Complement Med Ther 2020 May 13;20(1):146. Epub 2020 May 13.

Gastrointestinal Cancer Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Acute radiation-induced proctitis (ARP) is the most common side effect following radiotherapy for malignant pelvic disease. This study evaluated the efficacy of Aloe vera ointment in prevention of ARP.

Methods: Forty-two patients receiving external-beam radiotherapy (RT) for pelvic malignancies were randomized to receive either Aloe vera 3% or placebo topical ointment during radiotherapy for 6 weeks. Read More

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http://dx.doi.org/10.1186/s12906-020-02935-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222341PMC

Elderly-onset vs adult-onset ulcerative colitis: a different natural history?

BMC Gastroenterol 2020 May 12;20(1):147. Epub 2020 May 12.

Gastroenterology Unit, Spedali Civili Hospital - University of Brescia, Viale Europa, 11, 25123, Brescia, Italy.

Background: Incidence of ulcerative colitis (UC) in elderly population is increasing because of ageing and because of its minimal impact on life span. Data on natural history, outcomes and therapeutic strategies are limited. Our aim is to characterize UC in elderly-onset patients followed at our Inflammatory Bowel Disease outpatient clinic and compare with adult-onset UC. Read More

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http://dx.doi.org/10.1186/s12876-020-01296-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216336PMC

TMT-labelled quantitative proteomic analysis to identify the proteins underlying radiation-induced colorectal fibrosis in rats.

J Proteomics 2020 May 5;223:103801. Epub 2020 May 5.

Department of Colorectal Surgery, Fujian Medical University Union Hospital, People's Republic of China. Electronic address:

Radiation-induced colorectal fibrosis (RICF) after pelvic radiotherapy can lead to stenosis and affect patients' quality of life. However, to date, few effective prevention and treatment methods for RICF have been implemented in clinical practice. Therefore, there is a strong need to investigate the molecular events underlying radiation-induced intestinal fibrosis. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103801DOI Listing

The use of ICD codes to identify IBD subtypes and phenotypes of the Montreal classification in the Swedish National Patient Register.

Scand J Gastroenterol 2020 Apr 6;55(4):430-435. Epub 2020 May 6.

Department of Internal Medicine, Central Hospital, Karlstad, Sweden.

Whether data on International Classification of Diseases (ICD)-codes from the Swedish National Patient Register (NPR) correctly correspond to subtypes of inflammatory bowel disease (IBD) and phenotypes of the Montreal classification scheme among patients with prevalent disease is unknown. We obtained information on IBD subtypes and phenotypes from the medical records of 1403 patients with known IBD who underwent biological treatment at ten Swedish hospitals and retrieved information on their IBD-associated diagnostic codes from the NPR. We used previously described algorithms to define IBD subtypes and phenotypes. Read More

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http://dx.doi.org/10.1080/00365521.2020.1740778DOI Listing

MnTE-2-PyP, a manganese porphyrin, reduces cytotoxicity caused by irradiation in a diabetic environment through the induction of endogenous antioxidant defenses.

Redox Biol 2020 Apr 21;34:101542. Epub 2020 Apr 21.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Radiation is a common anticancer therapy for many cancer patients, including prostate cancer. Diabetic prostate cancer patients suffer from increased lymph node metastasis, tumor recurrence and decreased survival as compared to non-diabetic prostate cancer patients. These patients are also at increased risk for enhanced radiation-induced normal tissue damage such as proctitis. Read More

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http://dx.doi.org/10.1016/j.redox.2020.101542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200317PMC

Correlation between biomarkers (calprotectin, seromucoid, metalloproteinase-3 and CRP) and clinical and endoscopic activity of ulcerative colitis in children.

Adv Med Sci 2020 Apr 28;65(2):259-264. Epub 2020 Apr 28.

Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Wroclaw, Poland.

Purpose: The aim of the study was to compare the clinical activity and inflammatory markers with the endoscopic activity of ulcerative colitis (UC) and mucosal healing.

Patients And Methods: The study included 50 children aged 2-18 years (27 girls, 23 boys) diagnosed with UC at various stages of the disease; 8 children were assessed twice. In 20 children, colonoscopy revealed pancolitis, in 24 - left-sided colitis, and in 6 - ulcerative proctitis. Read More

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http://dx.doi.org/10.1016/j.advms.2020.03.004DOI Listing

Infectious Proctitis.

N Engl J Med 2020 Apr;382(17):1638

Griffin Hospital, Derby, CT

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http://dx.doi.org/10.1056/NEJMicm1906077DOI Listing

Rates of rectal toxicity in patients treated with high dose rate brachytherapy as monotherapy compared to dose-escalated external beam radiation therapy for localized prostate cancer.

Radiother Oncol 2020 Mar 31;147:123-129. Epub 2020 Mar 31.

Oakland University William Beaumont School of Medicine, Royal Oak, USA. Electronic address:

Background: Using a prospectively collected institutional database, we compared rectal toxicity following high dose rate (HDR) brachytherapy as monotherapy relative to dose-escalated external beam radiotherapy (EBRT) for patients with localized prostate cancer.

Methods: 2683 patients treated with HDR or EBRT between 1994 and 2017 were included. HDR fractionation was 38 Gy/4 fractions (n = 321), 24 Gy/2 (n = 96), or 27 Gy/2 (n = 128). Read More

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http://dx.doi.org/10.1016/j.radonc.2020.03.033DOI Listing

Management of Hemorrhoidal Disease in Special Conditions: A Word of Caution.

Rev Recent Clin Trials 2020 Apr 6. Epub 2020 Apr 6.

Department of Surgical Sciences, University of Turin, Città della Salute e della Scienza Hospital. Italy.

Background: Hemorrhoids are a common disease, that is often considered an easy problem to solve. Unfortunately, some particular clinical conditions, including Inflammatory Bowel Diseases (IBD), pregnancy, coagulophaties, immunosuppression, cirrhosis with portal hypertension, and proctitis after radiotherapy, challenge the hemorrhoids management and the outcomes.

Methods: Research and online contents related to hemorrhoids' treatment in special conditions is reviewed in order to help colorectal surgeons in daily practice. Read More

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http://dx.doi.org/10.2174/1574887115666200406121308DOI Listing

Proctitis: a glance beyond inflammatory bowel diseases.

Minerva Gastroenterol Dietol 2020 Mar 24. Epub 2020 Mar 24.

Unit of Gastroenterology, Molinette Hospital, Turin, Italy -

Proctitis is an inflammation involving the anus and the distal part of the rectum, frequently diagnosed in the context of inflammatory bowel diseases (IBD). Nevertheless, when the standard therapy for IBD is ineffective, it becomes necessary for the clinician to review alternative etiologies, beginning from the broad chapter of infectious causes up to rare causes such as radiation, ischemia, diversion and traumatisms. While it is possible to find infectious proctitides caused by pathogens generally inducing extensive colitis, the growing incidence of both sexually transmitted infections and isolated proctitis reported in the recent years require a lot of attention. Read More

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http://dx.doi.org/10.23736/S1121-421X.20.02670-7DOI Listing

Inflammatory pseudotumor associated with HSV infection of rectal vascular endothelium in a patient with HIV: a case report and literature review.

BMC Infect Dis 2020 Mar 19;20(1):234. Epub 2020 Mar 19.

Department of Pathology, University of Massachusetts Memorial Health Care, 1 Innovation Drive, Worcester, MA, 01605, USA.

Background: Herpes simplex virus (HSV) typically infects oral or anogenital squamous epithelium and causes blisters and ulcerations. Here we reported an unusual case of HSV induced exuberant rectal inflammatory pseudotumor with vascular endothelial involvement.

Case Presentations: A 52-year old man with HIV presented with abdominal pain, rectal drainage and constipation. Read More

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http://dx.doi.org/10.1186/s12879-020-04960-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082974PMC

Association between acute histopathological changes of rectal walls and late radiation proctitis following radiotherapy for prostate cancer.

Strahlenther Onkol 2020 Mar 12. Epub 2020 Mar 12.

Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy.

Purpose: The impact of acute histopathological changes (HC) of the rectum on development of late clinical proctitis (LCP) after external radiotherapy (RT) for prostate cancer is poorly explored and was the primary end point of this prospective study.

Methods: In 70 patients, 15 HC of early rectal biopsies after RT were identified, whereby RT was conventional 2D RT in 41 cases and conformational 3D RT in 29. Associations of HC in anterior and posterior rectal walls (ARW, PRW) with LCP, acute endoscopic (AEP) and acute clinical proctitis (ACP) were statistically evaluated considering as explicative variables the patient general characteristics and the HC. Read More

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http://dx.doi.org/10.1007/s00066-020-01590-3DOI Listing

Pravastatin Alleviates Radiation Proctitis by Regulating Thrombomodulin in Irradiated Endothelial Cells.

Int J Mol Sci 2020 Mar 10;21(5). Epub 2020 Mar 10.

Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.

Although radiotherapy plays a crucial in the management of pelvic tumors, its toxicity on surrounding healthy tissues such as the small intestine, colon, and rectum is one of the major limitations associated with its use. In particular, proctitis is a major clinical complication of pelvic radiotherapy. Recent evidence suggests that endothelial injury significantly affects the initiation of radiation-induced inflammation. Read More

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http://dx.doi.org/10.3390/ijms21051897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084904PMC

Diagnosis and management of a solitary colorectal juvenile polyp in an adult during follow-up for ulcerative colitis: A case report.

World J Gastroenterol 2020 Feb;26(8):877-882

Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China.

Background: Juvenile polyps are the most common type of polyps in children but are rare in adults. Inflammatory bowel disease (IBD) patients have a similar spectrum of symptoms as patients with juvenile polyps. Both patients with juvenile polyps and those with active IBD have high fecal calprotectin levels. Read More

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http://dx.doi.org/10.3748/wjg.v26.i8.877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052536PMC
February 2020

Diverting colostomy is an effective and reversible option for severe hemorrhagic radiation proctopathy.

World J Gastroenterol 2020 Feb;26(8):850-864

Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Guangdong Province, China.

Background: Severe chronic radiation proctopathy (CRP) is difficult to treat.

Aim: To evaluate the efficacy of colostomy and stoma reversal for CRP.

Methods: To assess the efficacy of colostomy in CRP, patients with severe hemorrhagic CRP who underwent colostomy or conservative treatment were enrolled. Read More

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http://dx.doi.org/10.3748/wjg.v26.i8.850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052535PMC
February 2020

South Asian Patients With Inflammatory Bowel Disease in the United States Demonstrate More Fistulizing and Perianal Crohn Phenotype.

Inflamm Bowel Dis 2020 Mar 2. Epub 2020 Mar 2.

Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: South Asians have recently been identified as having a rapidly rising incidence and prevalence of inflammatory bowel disease (IBD) throughout the world. However, longitudinal phenotypic studies of South Asians living in the United States remain scarce.

Methods: We retrospectively studied 171 South Asian patients with IBD treated at 2 US tertiary centers who presented between 2000 and 2016. Read More

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http://dx.doi.org/10.1093/ibd/izaa029DOI Listing

Clinical Outcomes of Dose-escalated Radiotherapy for Localised Prostate Cancer: A Single-institution Experience.

In Vivo 2020 Mar-Apr;34(2):757-765

Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore

Background/aim: To report the outcomes of patients with prostate cancer treated with dose-escalated radiotherapy over a 15-year period at our Institution.

Patients And Methods: Patients with biopsy-proven cT1-4N0M0 disease who received radical external beam radiotherapy (EBRT) were reviewed. The endpoints were 5-year overall survival (OS), freedom from biochemical failure (FFBF) and late treatment toxicities. Read More

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http://dx.doi.org/10.21873/invivo.11835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157896PMC
October 2019

Syphilitic Proctitis With Clinical Features of Lymphoma.

Clin Gastroenterol Hepatol 2020 Feb 25. Epub 2020 Feb 25.

Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.cgh.2020.02.031DOI Listing
February 2020

Low Incidence of Inflammatory Bowel Disease Adverse Events in Adalimumab Clinical Trials Across Nine Different Diseases.

Arthritis Care Res (Hoboken) 2020 Feb 26. Epub 2020 Feb 26.

University of Alabama at Birmingham, Birmingham, AL, United States.

Objective: Adalimumab is approved for treatment of Crohn's disease and ulcerative colitis. Thus, we postulated that exacerbation or new-onset of inflammatory bowel disease (IBD) would be rare events in patients treated with adalimumab for non-IBD indications. This analysis evaluated the incidence of IBD adverse events (AEs) across adalimumab trials. Read More

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http://dx.doi.org/10.1002/acr.24175DOI Listing
February 2020

Systemic Lupus Erythematosus Presenting with Ischemic Proctitis and Abdominal Compartment Syndrome.

Case Rep Gastrointest Med 2020 13;2020:5723403. Epub 2020 Feb 13.

Department of Medicine, Section of Pulmonary and Critical Care Medicine, West Virginia University, Morgantown, WV, USA.

Ischemic colitis and proctitis is a rare manifestation of systemic lupus erythematosus (SLE) and results from mesenteric vasculitis. Owing to diverse blood supply and presence of multiple collaterals, rectum is the least effected site in SLE enteritis. Ischemic proctocolitis as the presenting feature of SLE is exceedingly rare, with only three cases reported in the published scientific literature. Read More

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http://dx.doi.org/10.1155/2020/5723403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040385PMC
February 2020

[Proctitis: Thinking beyond inflammatory disease and malignancy].

Semergen 2020 Feb 22. Epub 2020 Feb 22.

EAP Encants, CAP Passeig de Maragall, Institut Catala de la Salut, Barcelona, España.

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http://dx.doi.org/10.1016/j.semerg.2019.12.014DOI Listing
February 2020

[Radiotherapy associated chronic hemorrhagic proctitis at the National Institute of Neoplastic Diseases of Peru, 2011-2013].

Rev Gastroenterol Peru 2019 Oct-Dec;39(4):329-334

Servicio de Gastroenterología, Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.

Objective: To study the clinical and endoscopic features of chronic hemorrhagic proctitis by radiotherapy in the National Institute of Neoplastic Diseases of Peru.

Materials And Methods: The study was descriptive, retrospective and longitudinal, with a population of 588 patients with this pathology, in the period 2011-2013, from which 114 patients were selected by randomized probabilistic sampling. Descriptive and inferential statistics were used for the analysis of qualitative and quantitative variables. Read More

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February 2020

Post-HIFU locally relapsed prostate cancer: high-dose salvage radiotherapy guided by molecular imaging.

Radiol Med 2020 May 19;125(5):491-499. Epub 2020 Feb 19.

Advanced Radiation Oncology Department, Cancer Care Center, IRCCS Sacro Cuore Don Calabria Hospital, Via Don Sempreboni 5, 37034, Verona, Negrar, Italy.

Purpose: To evaluate tolerance and biochemical control rates of salvage external beam radiotherapy (EBRT) in patients with local relapse from prostate cancer (PC) after high-intensity focused ultrasound (HIFU) as primary treatment.

Methods: Twenty-four patients presented biochemical failure of PC. Salvage EBRT to the residual prostate was performed with moderate hypofractionation schedule (MHRT) in 28 fractions (n = 16) or with extreme hypofractionation schedule (SBRT) in 5 fractions (n = 8) by means of image-guided volumetric modulation arc therapy. Read More

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http://dx.doi.org/10.1007/s11547-020-01148-4DOI Listing

Moderately HRT vs. CRT for localized prostate cancer using image-guided VMAT with SIB: evaluation of acute and late toxicities.

Strahlenther Onkol 2020 Feb 10. Epub 2020 Feb 10.

Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hanover, Germany.

Purpose: This retrospective study aims at investigating the effects of moderately hypofractionated radiation therapy (HRT) on acute and late toxicities as well as on early biochemical control and therapeutic efficiency compared to conventional radiation therapy (CRT) in prostate cancer.

Patients And Methods: We analyzed 55 HRT patients irradiated with the total dose of 60 Gy in 20 fractions delivered over 4 weeks. These patients were compared to a control group of 55 patients who received CRT with a total of <78 Gy in 37-39 fractions delivered over circa 8 weeks. Read More

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http://dx.doi.org/10.1007/s00066-020-01589-wDOI Listing
February 2020

Expert Commentary on the Evaluation and Management of Radiation Proctitis.

Dis Colon Rectum 2020 Mar;63(3):288-289

Phoenix, Arizona.

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http://dx.doi.org/10.1097/DCR.0000000000001593DOI Listing

Evaluation and Management of Chronic Radiation Proctitis.

Dis Colon Rectum 2020 Mar;63(3):285-287

Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1097/DCR.0000000000001592DOI Listing

[Classical sexually transmitted diseases in the anorectal region].

Hautarzt 2020 Apr;71(4):275-283

Klinik für Dermatologie und Venerologie, Universitätsklinikum Essen, Essen, Deutschland.

Background: Sexually transmitted infections (STIs) in the anorectal region are disproportionally detected in risk populations such as men who have sex with men (MSM). However, due to changes in sexual behaviour they are increasingly diagnosed in heterosexual individuals. Due to the recent implementation of oral HIV pre-exposure prophylaxis together with lack of condom use, a further rise in STIs is expected. Read More

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http://dx.doi.org/10.1007/s00105-020-04547-wDOI Listing

Hydrogen Peroxide Enema-induced Proctitis in a Young Female: A Case Report.

Cureus 2019 Dec 26;11(12):e6468. Epub 2019 Dec 26.

Gastroenterology, AdventHealth, Orlando, USA.

Hydrogen peroxide is a disinfectant commonly used for cleansing superficial wounds due to its oxidizing capacity. In the past, it has also been used for the management of meconium ileus in children as the oxidizing action of hydrogen peroxide potentiates peristalsis that relieves ileus or fecal impaction. The potential dangers were unknown till Pumphrey, in 1951, described the harmful effects of its use as an enema. Read More

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http://dx.doi.org/10.7759/cureus.6468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984182PMC
December 2019

Granulomas, Proctitis, and HIV: Complex Diagnosis with a Simple Treatment.

Gastroenterology 2020 May 1;158(6):1546-1547. Epub 2020 Feb 1.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic Health System, Mankato, Minnesota.

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http://dx.doi.org/10.1053/j.gastro.2020.01.035DOI Listing

Selection Criteria and Clinical Outcomes of Patients With Asymmetrical Cervical Cancer Treated With Various High-dose-rate Brachytherapy Techniques.

Anticancer Res 2020 Feb;40(2):999-1006

Department of Radiation Oncology & Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan.

Background/aim: We aimed to evaluate the efficacy of high-dose-rate brachytherapy techniques selected according to pre-brachytherapy magnetic resonance imaging (MRI) findings in asymmetrical cervical cancer (ACC).

Patients And Methods: We analyzed 33 ACC patients. Asymmetric tumors were defined as those in which the difference between the distance from the cervical canal to the farthest end of the tumor [long distance (LD)] and the distance from the cervical canal to the contralateral tumor edge [short distance (SD)] is equal to or greater than 2 cm on the basis of MRI prior to treatment. Read More

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http://dx.doi.org/10.21873/anticanres.14034DOI Listing
February 2020

Proctitis in gay and bisexual men. Are microscopy and proctoscopy worthwhile?

Sex Transm Infect 2020 Jan 30. Epub 2020 Jan 30.

The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

Objectives: We explored the association between nucleic acid amplification testing (NAAT) and rectal microscopy/proctoscopy findings and correlates of rectal STIs among 150 gay and bisexual men (GBM) diagnosed with proctitis at the Sydney Sexual Health Centre from March 2016 to October 2017.

Methods: From case files, we analysed risk behaviours, microscopy, proctoscopy and NAAT results for rectal STIs (, , , herpes simplex virus type 1/2, lymphogranuloma venereum and syphilis). χ test assessed the association between microscopy/proctoscopy findings and NAAT results. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054197DOI Listing
January 2020

Improved treatment outcome and lower skin toxicity with intensity-modulated radiotherapy vs. 3D conventional radiotherapy in anal cancer.

Strahlenther Onkol 2020 Apr 24;196(4):356-367. Epub 2020 Jan 24.

Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich University, Zurich, Switzerland.

Purpose: Radiochemotherapy is the standard treatment for anal carcinoma (ACa). Intensity-modulated radiotherapy (IMRT) has been introduced, allowing focused irradiation of the tumor area. Whether physical benefits of IMRT translate to clinical benefits has not been sufficiently demonstrated. Read More

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http://dx.doi.org/10.1007/s00066-019-01534-6DOI Listing

[Anal herpes simplex virus infections].

Authors:
Albert Rübben

Hautarzt 2020 Apr;71(4):293-297

Hautklinik am Universitätsklinikum Aachen, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

Background: Herpes simplex virus (HSV) type 1 and type 2 may infect the anal region and induce aphthous ulcers. HSV-induced proctitis may be severe with fever, anal pain, anal bleeding, and diarrhea.

Objectives: The pathogenic agents and treatment are reviewed. Read More

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http://dx.doi.org/10.1007/s00105-019-04539-5DOI Listing

Elective surgery for ulcerative colitis, ileo-rectal anastomosis or restorative proctocolectomy An Update.

Ann Ital Chir 2019 ;90:565-573

Background: Despite advances in the medical management of Ulcerative Colitis (UC), surgery is required in about a third of patients.

Aims And Methods: A review of the literature of the last 20 years was conducted in order to analyze the results of Ileo-Rectal Anastomosis (IRA) and of Ileal Pouch-Anal Anastomosis (IPAA) in the treatment of mild-to-moderate UC. Postoperative complications, functional results and the risk of cancer were analyzed in each of the two groups of patients. Read More

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January 2019

Post hemorrhoidectomy complications: CT imaging findings.

Clin Imaging 2020 Apr 28;60(2):216-221. Epub 2019 Dec 28.

Department of Diagnostic Imaging, Chaim Sheba Medical Center, Ramat Gan, Israel; Sackler School of Medicine, Tel-Aviv University, Israel. Electronic address:

Introduction: We aimed to describe computed tomography (CT) findings of early complications after interventional hemorrhoid treatments in emergency department (ED) patients.

Materials And Methods: We identified all ED patients requiring abdominal and/or pelvic CT between February 2012 and February 2019, and included only patients who underwent CT for suspected early (up to 30 days) post hemorrhoidectomy procedure complications. Presenting symptoms, salient CT findings and clinical outcomes were collected. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.12.015DOI Listing

Linked color imaging improves visibility of ectatic vessels in radiation proctitis during argon plasma coagulation.

Dig Endosc 2020 Mar 9;32(3):e45-e46. Epub 2020 Jan 9.

Department of Gastroenterology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1111/den.13590DOI Listing
March 2020
1.989 Impact Factor

Special Considerations in the GI Bleeding Patient.

Clin Colon Rectal Surg 2020 Jan 7;33(1):35-41. Epub 2019 Nov 7.

Section of Colon and Rectal Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Lower gastrointestinal bleeding (LGIB) is an increasingly common problem in patients with comorbid medical conditions that place them at higher bleeding risk. This discussion of some special considerations in the GI bleeding patient encompasses an overview of the elderly patient, and selects comorbid conditions that place patients at higher risk of developing intestinal bleeding. The discussion lends itself to exploring the challenges of and new advancements in anticoagulation therapy. Read More

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http://dx.doi.org/10.1055/s-0039-1695036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946599PMC
January 2020

A phase 2 randomized controlled trial of oral resistant starch supplements in the prevention of acute radiation proctitis in patients treated for cervical cancer.

J Cancer Res Ther 2019 Oct-Dec;15(6):1383-1391

Department of Gastroenterology, Christian Medical College Hospital, Vellore; Department of Medical Gastroentrology, Institute of Gastroenterology, Hepatobiliary Science and Transplantation SRM Institutes for Medical Science, Chennai, Tamil Nadu, India.

Background: Radiation induced proctitis is frequently encountered during the radiation therapy of cervical and prostate cancers that causes pain and occasionally with bleeding and may affect the continuity of radiation therapy.

Aims And Objectives: The purpose of the study is to look at the benefit of administration of an oral prebiotic amylase resistant starch in reducing the incidence of acute radiation proctitis, a distressing symptom in patients receiving radiation therapy for cancer of the cervix.

Material And Methods: The study was conducted between 2011 and 2014 in 104 patients receiving radical chemo-radiotherapy for carcinoma cervix. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_152_19DOI Listing

[Underdiagnosis of lymphogranuloma venereum].

Rev Esp Quimioter 2020 Feb 2;33(1):76-77. Epub 2020 Jan 2.

Berta Pino Calm, Unidad de Microbiología y Parasitología. Servicio de Análisis Clínicos, Hospital Universitario Nuestra Señora de Candelaria. Ctra. del Rosario, 145, 38010 Santa Cruz de Tenerife. Spain.

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http://dx.doi.org/10.37201/req/061.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987622PMC
February 2020

Syphilitic proctitis imitating rectal malignancy.

Eur J Gastroenterol Hepatol 2020 Feb;32(2):285-286

Department of Medical Imaging, Taipei Medical University Hospital.

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http://dx.doi.org/10.1097/MEG.0000000000001645DOI Listing
February 2020

Evaluating the predictive value of quantec rectum tolerance dose suggestions on acute rectal toxicity in prostate carcinoma patients treated with IMRT.

Rep Pract Oncol Radiother 2020 Jan-Feb;25(1):50-54. Epub 2019 Dec 9.

Suleyman Demirel University, Department of Radiation Oncology, Isparta, Turkey.

Aim: To investigate the predictive value of convenience of rectum dosimetry with Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) dose limits, maximum rectum dose (Dmax), total rectal volume (TVrectum), rectal volume included in PTV (VrectumPTV) on Grade 2-3 acute rectal toxicity for utilization in clinical practice.

Background: Numerous previous data have reported frequent acute proctitis after external-beam RT of prostate cancer. Predicting toxicity limited with dose information is inadequate in clinical practice due to comorbidities and medications used. Read More

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http://dx.doi.org/10.1016/j.rpor.2019.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931199PMC
December 2019

A Rare Case of Disseminated Presenting as Proctitis.

Case Rep Gastrointest Med 2019 3;2019:8129597. Epub 2019 Dec 3.

Division of Gastroenterology, BronxCare Hospital Center a Clinical Affiliate of Mt Sinai Health Systems and Academic Affiliate of Icahn School of Medicine, Bronx, NY 10457, USA.

(MAI) infections are common in (HIV) positive patients. MAI infection can have localized or disseminated presentation, patients with low CD4 count presenting with disseminated infection. Fever, abdominal pain, diarrhea, and weight loss are generally the presenting symptoms of disseminated MAI. Read More

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http://dx.doi.org/10.1155/2019/8129597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914957PMC
December 2019

Inflammatory bowel disease versus Chlamydia trachomatis infection: a case report and revision of the literature.

Eur J Gastroenterol Hepatol 2020 Mar;32(3):454-457

Department of Systems Medicine, Unit of Gastroenterology, University 'Tor Vergata' of Rome.

Infectious proctitis may mimic inflammatory bowel disease, particularly when limited to the rectum. The present case report includes findings from a 50-year-old man, soldier, referring to our Inflammatory Bowel Disease Unit with a diagnosis of rectal Crohn's disease, refractory to conventional treatments. Mild anemia, hypergammaglobulinemia and HIV-antibodies seronegativity were detected. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001605DOI Listing

Lymphogranuloma Venereum Proctitis.

Clin Gastroenterol Hepatol 2019 Dec 13. Epub 2019 Dec 13.

Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://dx.doi.org/10.1016/j.cgh.2019.12.009DOI Listing
December 2019

Effect of interval between preoperative radiotherapy and surgery on clinical outcome and radiation proctitis in rectal cancer from FOWARC trial.

Cancer Med 2020 Feb 12;9(3):912-919. Epub 2019 Dec 12.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Objective: The aim of this study was to evaluate the effect of the interval between CRT and surgery on radiation proctitis, the pathologic response, and postoperative morbidity.

Methods: This was a cohort study from a phase III, randomized controlled trial (FOWARC study, NCT01211210). Data were retrieved from the leading center of the trial. Read More

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http://dx.doi.org/10.1002/cam4.2755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997091PMC
February 2020

Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea.

Gut 2019 Dec 10. Epub 2019 Dec 10.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (the Republic of)

Objective: No population-based study has evaluated the natural course of UC over three decades in non-Caucasians. We aimed to assess the long-term natural course of Korean patients with UC in a population-based cohort.

Design: This Korean population-based, Songpa-Kangdong IBD cohort included all patients (n=1013) newly diagnosed with UC during 1986-2015. Read More

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http://dx.doi.org/10.1136/gutjnl-2019-319699DOI Listing
December 2019
14.660 Impact Factor