4,220 results match your criteria Proctitis


Total neoadjuvant approach with FOLFOXIRI plus bevacizumab followed by chemoradiotherapy plus bevacizumab in locally advanced rectal cancer: the TRUST trial.

Eur J Cancer 2019 Feb 7;110:32-41. Epub 2019 Feb 7.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma, 56126 Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 56126 Pisa, Italy. Electronic address:

Background: Neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC) does not achieve effective control of distant metastases. Induction chemotherapy is a promising strategy, and bevacizumab (BV) could improve the results of CRT. 5-Fluorouracil, oxaliplatin and irinotecan (FOLFOXIRI) plus BV is a treatment option in metastatic colorectal cancer. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.006DOI Listing
February 2019
1 Read

A rare case of Fitz-Hugh-Curtis syndrome caused by in an HIV-positive male patient.

SAGE Open Med Case Rep 2019 16;7:2050313X18823592. Epub 2019 Jan 16.

University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', Zagreb, Croatia.

Fitz-Hugh-Curtis syndrome, a rare complication of pelvic inflammatory disease, is an inflammation of the liver capsule (thus called perihepatitis) and the surrounding peritoneum. It occurs extremely rarely in men and is typically characterized by a sudden onset of severe pain in the right upper abdominal quadrant. Ultrasound examination of the liver does not reveal any morphologic changes, and liver function tests are usually normal. Read More

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http://dx.doi.org/10.1177/2050313X18823592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350016PMC
January 2019
3 Reads

A case report of proctitis associated with Mycoplasma genitalium in a man who has sex with men.

Int J STD AIDS 2019 Feb 5:956462419825896. Epub 2019 Feb 5.

3 STI Unit Vall d'Hebron - Drassanes, Infectious Diseases Department, Hospital Vall d'Hebron, Barcelona, Spain.

Mycoplasma genitalium is an infection of increasing concern due to its potential to cause sequelae in the reproductive tract and the development of antimicrobial resistance. Its role as a cause of proctitis in people with high-risk sexual behaviour has not been properly defined yet but it seems to be less symptomatic than proctitis caused by Chlamydia trachomatis or Neisseria gonorrhoeae. We present a case of a man who has sex with men with proctitis associated with M. Read More

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http://dx.doi.org/10.1177/0956462419825896DOI Listing
February 2019
1 Read

Gastrointestinal: Radiation proctitis: Or is it something else?

J Gastroenterol Hepatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Gastroenterology, GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.

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http://dx.doi.org/10.1111/jgh.14592DOI Listing
January 2019
1 Read

Rubber Band Ligation of Hemorrhoids is often a Necessary Complement in the Management of Hemorrhagic Radiation Proctitis.

Scand J Surg 2019 Jan 11:1457496918822619. Epub 2019 Jan 11.

1 Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Background:: Management of radiation proctitis presents a treatment challenge. Limited data exist on the management of symptomatic hemorrhoids in radiated patients. This study aims to present a practical approach to the management of radiation proctitis, particularly in patients with synchronous hemorrhoids. Read More

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http://dx.doi.org/10.1177/1457496918822619DOI Listing
January 2019
1 Read

Rectal Submucosal Tumor Mimicking a Neuroendocrine Tumor.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2171-18DOI Listing
January 2019

A phase I pilot study of pre-operative radiotherapy for prostate cancer: Long-term toxicity and oncologic outcomes.

Int J Radiat Oncol Biol Phys 2019 Jan 6. Epub 2019 Jan 6.

Department of Radiation Oncology, University of Toronto, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Techna Institute, University Health Network, Toronto, Canada. Electronic address:

Background: Neoadjuvant radiotherapy (RT) improves disease control in various cancers, and has become an established oncologic treatment strategy. During 2001-2004, we conducted a phase I pilot study assessing the role of short-course pre-operative RT (PreORT) for men with unfavourable intermediate- and high-risk localized prostate cancer. Herein, we present long-term follow-up toxicity and oncologic outcomes. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.054DOI Listing
January 2019
3 Reads

[Chinese consensus on diagnosis and treatment of radiation proctitis (2018)].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Dec;21(12):1321-1336

Surgeon Branch of Chinese Medical Doctor Association, Colorectal Surgery Group of Surgery Branch in the Chinese Medical Association.

Radiation proctitis denotes the radiation damage of rectum caused by radiotherapy to pelvic malignancy. The clinical practices of radiation proctitis should be fully considered from diagnosis, treatment and prevention. In order to determine appropriate treatment strategies, the diagnosis of radiation proctitis should be based on clinical symptoms, endoscopic findings, imaging and histopathology to assess severity of symptoms and stage of disease. Read More

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December 2018
21 Reads

Argon plasma coagulation is an effective treatment for chronic radiation proctitis in gynaecological malignancy: an observational study.

Colorectal Dis 2018 Dec 26. Epub 2018 Dec 26.

Department of Gastroenterology, School of Digestive and Liver disease, Kolkata, West Bengal, India.

Aim: Chronic radiation proctitis (CRP) develops in 5-15% of patients after pelvic radiation therapy, with rectal bleeding being the main symptom. Reports suggest that argon plasma coagulation (APC) can be an effective therapy for CRP following radiotherapy for prostate cancer, but there is less information about how useful it is after radiotherapy for gynaecological malignancy. The aim of this work therefore was to study the efficacy of APC for CRP after radiotherapy for gynaecological malignancy. Read More

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http://dx.doi.org/10.1111/codi.14541DOI Listing
December 2018
1 Read

Looking at the positives: proactive management of STIs in people with HIV.

AIDS Res Ther 2018 Dec 21;15(1):28. Epub 2018 Dec 21.

Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.

Patients who are HIV-positive and co-infected with other sexually transmitted infections (STIs) are at risk of increased morbidity and mortality. This is of clinical significance. There has been a dramatic increase in the incidence of STIs, particularly syphilis, gonorrhoea, Mycoplasma genitalium and hepatitis C virus (HCV) in HIV-positive patients. Read More

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https://aidsrestherapy.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12981-018-0216-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302453PMC
December 2018
9 Reads

[Diagnostic validity of fecal occult blood test in infants with food protein-induced allergic proctocolitis].

Rev Chil Pediatr 2018 Oct;89(5):630-637

Laboratorio de Inmunología y Alergia Traslacional, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Pontificia Universidad Católica de Chile, Chile.

Introduction: Food protein-induced allergic proctocolitis (FPIAP) is the most frequent presenta tion of non-IgE mediated food allergy (FA). The diagnosis is made by oral food challenge, however, non-invasive diagnostic tests are not available. In Chile, the fecal occult blood test (FOBT) is fre quently used to confirm FPIAP, however, there are no studies that support this practice. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000901DOI Listing
October 2018
1 Read

Interference with the lower gut-liver axis induces remission of primary sclerosing cholangitis in a patient with ulcerative colitis.

BMJ Open Gastroenterol 2018 14;5(1):e000239. Epub 2018 Nov 14.

Department of Gastroenterology, Bedford Hospital South Wing, Bedford, UK.

The gut-liver axis describes the complex interactions between gut microbiota, the small and large bowel, the immune system and the liver. Current evidence associates abnormalities within the gut-liver axis with liver disease such as primary sclerosing cholangitis (PSC). PSC is believed to be an immune-mediated disease though the exact mechanism of its pathogenesis remains unknown. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267462PMC
November 2018
1 Read

THE ONSET OF CLINICAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE PATIENTS.

Arq Gastroenterol 2018 Jul-Sep;55(3):290-295

Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.

Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.

Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.

Methods: A cross-sectional study. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-73DOI Listing
January 2019

A Case of Asymptomatic Syphilitic Proctitis.

Sex Transm Dis 2018 Dec 3. Epub 2018 Dec 3.

Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles.

The incidence of syphilis is increasing. Syphilitic proctitis involving the rectal mucosa often presents with pain on defecation, rectal bleeding, or ulceration. We present a case of asymptomatic syphilitic proctitis diagnosed upon a routine screening colonoscopy. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000955DOI Listing
December 2018
2 Reads

Acetarsol in the management of mesalazine-refractory ulcerative proctitis: a tertiary-level care experience.

Eur J Gastroenterol Hepatol 2019 02;31(2):183-186

Nottingham Digestive Diseases Centre.

Background: Mesalazine-refractory ulcerative proctitis is common, with a significant proportion of the patients requiring escalation to immunomodulators or biological therapy. Three small preliminary cohort studies suggested good clinical efficacy for the organic arsenic derivative acetarsol in the management of proctitis. Our aim was to describe our experience on the use of acetarsol in proctitis and to review all existing evidence on its safety and efficacy. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001326DOI Listing
February 2019
17 Reads

Epidemiology and clinical course of inflammatory bowel disease in the Central Province of Sri Lanka: A hospital-based study.

JGH Open 2018 Aug 6;2(4):129-133. Epub 2018 Jun 6.

Gastroenterology and Hepatology Unit Teaching Hospital Kandy Kandy Sri Lanka.

Background And Aim: There is increasing prevalence of inflammatory bowel disease (IBD) in Asia, but Sri Lankan data on the state of epidemiology and clinical course of IBD are scarce.

Methods: A hospital-based study was done by recruiting IBD patients who permanently reside in the Central Province (population 2.57 million, 12. Read More

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http://doi.wiley.com/10.1002/jgh3.12058
Publisher Site
http://dx.doi.org/10.1002/jgh3.12058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207030PMC
August 2018
7 Reads

Hyaluronic acid for treatment of the radiation therapy side effects: a systematic review.

Authors:
D Cosentino F Piro

Eur Rev Med Pharmacol Sci 2018 Nov;22(21):7562-7572

Radiotherapy Oncology Center, Azienda Ospedaliera of Cosenza, Cosenza, Italy.

Objective: The main limit of radiation therapy is the dose-dependent toxicity to healthy tissues. The 36% of patients exposed to radiotherapy for pelvic malignancies reporting gastrointestinal symptoms as incontinence, pain, mucus discharge, and bleeding (radiation proctopathy). In the cervix cancer, healthy tissues exposed to radiations easily develop inflammation of vaginal mucosa, bleeding and pain and to improve these symptoms, some medical devices were developed. Read More

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http://dx.doi.org/10.26355/eurrev_201811_16298DOI Listing
November 2018
8 Reads

Randomized, double-blind, placebo-controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy.

Phytother Res 2019 Feb 14;33(2):370-378. Epub 2018 Nov 14.

Urology and Nephrology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinical potential of curcumin in radiotherapy (RT) setting is outstanding and of high interest. The main purpose of this randomized controlled trial (RCT) was to assess the beneficial role of nanocurcumin to prevent and/or mitigate radiation-induced proctitis in prostate cancer patients undergoing RT. In this parallel-group study, 64 eligible patients with prostate cancer were randomized to receive either oral nanocurcumin (120 mg/day) or placebo 3 days before and during the RT course. Read More

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http://doi.wiley.com/10.1002/ptr.6230
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http://dx.doi.org/10.1002/ptr.6230DOI Listing
February 2019
9 Reads

Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Nutrients 2018 Nov 12;10(11). Epub 2018 Nov 12.

Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR41110 Larissa, Greece.

Curcumin has demonstrated anti-inflammatory properties and has been investigated as an adjuvant therapy of ulcerative colitis (UC). The scope of this study was to systematically review and meta-analyze the efficacy of oral curcumin administration as an adjuvant therapy of UC. MEDLINE, Cochrane/CENTRAL, ClinicalTrials. Read More

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http://www.mdpi.com/2072-6643/10/11/1737
Publisher Site
http://dx.doi.org/10.3390/nu10111737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266508PMC
November 2018
8 Reads

Concurrent Chemo- Radiobrachytherapy with Cisplatin and Medium Dose Rate Intra- Cavitary Brachytherapy for Locally Advanced Uterine Cervical Cancer

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2745-2750. Epub 2018 Oct 26.

Radiation Oncology Research Center, Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Email:

Objective: Cervical carcinoma is the third most common gynecologic cancer, after ovarian and uterine cancers in Iran. The aim of this study was to evaluate the efficacy (response rate) and toxicity of adding Medium Dose Rate (MDR) brachytherapy with concurrent chemotherapy to External Beam Radiotherapy (EBRT) for the treatment of locally advanced uterine cervical carcinoma. Methods: This phase I-II study was conducted in 2007-2008 at the cancer institute, Tehran University of Medical Sciences. Read More

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http://journal.waocp.org/article_70390.html
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http://dx.doi.org/10.22034/APJCP.2018.19.10.2745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291044PMC
October 2018
8 Reads

Endoscopic progression of ulcerative proctitis to proximal disease. Can we identify predictors of progression?

Scand J Gastroenterol 2018 Oct - Nov;53(10-11):1286-1290. Epub 2018 Oct 23.

a Digestive Disease Department , General University Hospital of Valencia , Valencia , Spain.

Introduction: Ulcerative proctitis is a type of ulcerative colitis circumscribed to the rectum. Proximal progression rates of the disease have been reported as between 27% and 54%. Several predictive factors have been identified for its progression; however, none has been established as definitive. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1
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http://dx.doi.org/10.1080/00365521.2018.1524026DOI Listing
October 2018
9 Reads

Primary syphilitic proctitis : case report and literature review.

Acta Gastroenterol Belg 2018 Jul-Sep;81(3):430-432

Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.

Rectal ulcerations are an uncommon presentation of a primary syphilis infection. Anorectal syphilis is difficult to diagnose because of its often asymptomatic or atypical clinical presentation. It is important to consider sexually transmitted diseases (STD) in all patients presenting with rectal symptoms. Read More

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October 2018
6 Reads

Rectal Lymphoid Follicle Aphthous Lesions Frequently Progress to Ulcerative Colitis with Proximal Extension.

Intern Med 2018 Oct 17. Epub 2018 Oct 17.

Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Japan.

Objective Rectal lymphoid follicular aphthous (LFA) lesions are related to ulcerative colitis (UC) and can be initial lesions of UC. We investigated the clinical course and prognosis of rectal LFA lesions. Methods This is a retrospective analysis of the clinical records at a single center. Read More

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http://dx.doi.org/10.2169/internalmedicine.1635-18DOI Listing
October 2018
3 Reads

Usefulness of fecal calprotectin by monoclonal antibody testing in adult Japanese with inflammatory bowel diseases: a prospective multicenter study.

Intest Res 2018 Oct 10;16(4):554-562. Epub 2018 Oct 10.

Department of Medicine, Shiga University of Medical Science, Otsu, Japan.

Background/aims: Noninvasive objective monitoring is advantageous for optimizing treatment strategies in patients inflammatory bowel disease (IBD). Fecal calprotectin (FCP) is superior to traditional biomarkers in terms of assessing the activity in patients with IBD. However, there are the differences among several FCP assays in the dynamics of FCP. Read More

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http://irjournal.org/journal/view.php?doi=10.5217/ir.2018.00
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http://dx.doi.org/10.5217/ir.2018.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223455PMC
October 2018
17 Reads

Early Onset Allergic Proctitis in a Preterm Neonate-A Case Report and Review of the Literature.

Pediatr Dev Pathol 2018 Oct 4:1093526618803770. Epub 2018 Oct 4.

3 Department of Pediatrics, Division of gastroenterology, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.

Cow's milk protein allergy/intolerance (CMPA/CMPI) is a common entity in the pediatric population with a nonspecific presentation ranging from gastrointestinal symptoms to systemic manifestations. Most infants with CMPI are term, and symptoms often appear in the week following the introduction of cow's milk-based formula. There is typically a significant delay in the onset of milk allergy in premature infants compared to full term. Read More

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http://journals.sagepub.com/doi/10.1177/1093526618803770
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http://dx.doi.org/10.1177/1093526618803770DOI Listing
October 2018
2 Reads
0.860 Impact Factor

Long-term Follow-up Results of CT-guided Daily Adaptive Radiation Therapy for Localized Prostate Cancer.

Anticancer Res 2018 Oct;38(10):5959-5962

Department of Radiology, National Defense Medical College, Saitama, Japan.

Background/aim: To examine whether CT-guided daily adaptive radiation therapy (ART) can be safely administered against localized prostate cancer.

Patients And Methods: Twenty-six patients with localized prostate adenocarcinoma were irradiated through opposed AP/PA fields up to 46 Gy, then CT-guided daily ART was performed through opposed lateral fields until 76 Gy at 2 Gy/fraction.

Results: Biochemical relapse-free survival was 89% at 3 years and 85% at 5 years and 76% at 7 years after ART, respectively. Read More

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http://dx.doi.org/10.21873/anticanres.12942DOI Listing
October 2018
2 Reads

Frequency, types, and treatment of anemia in Turkish patients with inflammatory bowel disease.

World J Gastroenterol 2018 Sep;24(36):4186-4196

Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Dokuz Eylül University, İzmir 35360, Turkey.

Aim: To specify the type and prevalence of anemia along with a treatment approach for inflammatory bowel disease (IBD).

Methods: We conducted a retrospective study on 465 patients who were diagnosed with IBD and followed up at our hospital from June 2015 to June 2016 [male: 254, female: 211; average age: 47 ± 14.4; Crohn's disease (CD): 257, Ulcerative Colitis (UC): 208]. Read More

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http://dx.doi.org/10.3748/wjg.v24.i36.4186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158484PMC
September 2018
10 Reads

Linear IgA bullous dermatosis associated with ulcerative proctitis: treatment challenge.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

Naval Medical Center, San Diego, California.

Linear IgA bullous dermatosis is a rare bullous disease in children and adults that can be associated with autoimmune conditions, malignancies, infections, or medication exposure. The definitive diagnosis relies on the biopsy. A 58-year-old man presented to our clinic with a pruritic vesicular and bullous eruption. Read More

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July 2018
3 Reads

The role of endoscopic evaluation for radiation proctitis in patients receiving intermediate-dose postoperative radiotherapy for rectal cancer.

Jpn J Clin Oncol 2018 Nov;48(11):988-994

Department of Radiation Oncology, Yonsei University College of Medicine, Seoul.

Objectives: High-dose pelvic radiotherapy (RT) is known to be associated with chronic radiation proctitis (RP). However, the effects of intermediate radiation doses are unknown. We assessed the incidence of late clinical RP among patients with rectal cancer receiving intermediate-dose postoperative RT, as well as the role of early endoscopic abnormalities in predicting RP development. Read More

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https://academic.oup.com/jjco/advance-article/doi/10.1093/jj
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http://dx.doi.org/10.1093/jjco/hyy126DOI Listing
November 2018
10 Reads
1.750 Impact Factor

Solitary extramedullary plasmacytoma of the rectum complicating ulcerative colitis.

Clin J Gastroenterol 2018 Sep 20. Epub 2018 Sep 20.

Department of Pathology, Nikko Medical Center, Dokkyo Medical University, Tochigi, Japan.

Solitary extramedullary plasmacytoma (EMP) arising in the rectum is an extremely rare clinical entity. Only ten cases have been reported in the English-language literature. We experienced a case of an EMP in the rectum of a 55-year-old man with an 8-year history of proctitis-type ulcerative colitis (UC). Read More

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http://link.springer.com/10.1007/s12328-018-0907-8
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http://dx.doi.org/10.1007/s12328-018-0907-8DOI Listing
September 2018
8 Reads

The role of multimodal treatment in Crohn's disease patients with perianal fistula: a multicentre retrospective cohort study.

Aliment Pharmacol Ther 2018 Nov 18;48(9):941-950. Epub 2018 Sep 18.

Milan, Italy.

Background: Treatment paradigms for Crohn's disease with perianal fistulae (CD-pAF) are evolving.

Aims: To study the impact of multimodality treatment in CD-pAF on recurrence rates and the need for re-interventions and to identify predictive factors for these outcomes.

Methods: This was a multinational multicentre retrospective cohort study. Read More

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http://dx.doi.org/10.1111/apt.14969DOI Listing
November 2018
7 Reads

Late toxicity after post-prostatectomy intensity modulated radiation therapy: Evaluating normal-tissue sparing guidelines.

Adv Radiat Oncol 2018 Jul-Sep;3(3):339-345. Epub 2018 May 8.

Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, Illinois.

Purpose: Dose-volume histogram (DVH) toxicity relationships are poorly defined in men who receive radiation after radical prostatectomy (RP). We evaluated Radiation Therapy Oncology Group (RTOG) study 0534 and institutional intact normal-tissue sparing guidelines, as well as dose to bladder trigone, for ability to minimize late toxicity.

Methods And Materials: 164 men received intensity modulated radiation therapy (RT) to a median prostate bed dose of 66. Read More

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http://dx.doi.org/10.1016/j.adro.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128032PMC
May 2018
5 Reads

Comparison of relative and absolute rectal dose-volume parameters and clinical correlation with acute and late radiation proctitis in prostate cancer patients.

Strahlenther Onkol 2019 Feb 6;195(2):103-112. Epub 2018 Sep 6.

Department of Radiotherapy and Special Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: To compare relative and absolute dose-volume parameters (DV) of the rectum and their clinical correlation with acute and late radiation proctitis (RP) after radiotherapy (RT) for prostate cancer (PCa).

Patients And Methods: 366 patients received RT for PCa. In total, 49. Read More

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http://dx.doi.org/10.1007/s00066-018-1365-4DOI Listing
February 2019
1 Read

Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis.

Exp Ther Med 2018 Sep 18;16(3):2319-2324. Epub 2018 Jul 18.

Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530007, P.R. China.

The aim of the present study was to investigate the safety and efficacy of mesalazine suppository in the treatment of refractory ulcerative chronic radiation proctitis (CRP). In total, 10 refractory ulcerative CRP patients who did not respond to previous medical treatments were recruited for the present study and were treated with mesalazine suppository (0.5 g) twice daily for 24 weeks. Read More

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http://dx.doi.org/10.3892/etm.2018.6464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122487PMC
September 2018
16 Reads
0.941 Impact Factor

Early and late toxicity profiles of patients receiving immediate postoperative radiotherapy versus salvage radiotherapy for prostate cancer after prostatectomy.

Strahlenther Onkol 2019 Feb 4;195(2):131-144. Epub 2018 Sep 4.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675, Munich, Germany.

Purpose: The present study aims to evaluate both early and late toxicity profiles of patients receiving immediate postoperative radiotherapy (RT; adjuvant RT or additive RT) compared to salvage RT.

Methods: We evaluated 253 patients with prostate cancer treated with either immediate postoperative (adjuvant RT, n = 42; additive RT, n = 39) or salvage RT (n = 137). Thirty-five patients received salvage treatment but did not achieve a postoperative prostate specific antigen (PSA) level <0. Read More

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http://dx.doi.org/10.1007/s00066-018-1359-2DOI Listing
February 2019
5 Reads

MRI Appearances of Colitis Cystica Profunda: A Rare Benign Mimicker of Colorectal Malignancy.

J Coll Physicians Surg Pak 2018 Sep;28(9):S162-S163

Department of Radiology, Shifa International Hospital, Islamabad.

Colitis cystica profunda (CCP) is a rare benign disease characterised by mucin-filled cysts beneath the muscularis mucosae, which commonly involves the rectum and sigmoid colon. The disease process involving rectum is termed as proctitis cystica profunda. Trans-rectal ultrasound (TRUS) and magnetic resonance imaging (MRI) are an aid to diagnosis. Read More

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https://www.jcpsp.pk/data/view.php?id=352&type=pdf&j
Publisher Site
http://dx.doi.org/10.29271/jcpsp.2018.09.S162DOI Listing
September 2018
11 Reads

International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study.

Radiat Oncol 2018 Aug 29;13(1):162. Epub 2018 Aug 29.

Department of Radiation Oncology, Sir Charles Gairdner Hospital, Perth, Western Australia.

Background: Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in patients who were receiving pelvic radiotherapy.

Methods: Patients (n = 358) from six countries completed the EORTC QLQ-C30, QLQ-PRT23 and EORTC Quality of Life Group debriefing questions. Read More

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http://dx.doi.org/10.1186/s13014-018-1107-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116442PMC
August 2018
3 Reads

Delayed diagnosis of colorectal sexually transmitted diseases due to their resemblance to inflammatory bowel diseases.

Int J Infect Dis 2018 Oct 17;75:34-38. Epub 2018 Aug 17.

Infectious Disease Unit, Sheba Medical Center, Ramat Gan, Israel; Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.

Objective: Sexually transmitted diseases (STDs), mainly lymphogranuloma venereum (LGV), induce colorectal symptoms that may be misdiagnosed as inflammatory bowel disease (IBD). This study describes patients who presented with STDs masquerading as IBD in order to improve understanding of missed diagnosis of colorectal STDs and their association with LGV in Israel.

Methods: This retrospective, descriptive study characterized the clinical, endoscopic, and pathological findings of 16 patients who were diagnosed with a colorectal STD after erroneously being diagnosed with IBD. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.004DOI Listing
October 2018
13 Reads

A systematic post-QUANTEC review of tolerance doses for late toxicity after prostate cancer radiotherapy.

Int J Radiat Oncol Biol Phys 2018 Aug 17. Epub 2018 Aug 17.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:

Purpose: The aim of this study was to systematically review tolerance doses for late distinct gastrointestinal, genitourinary, and sexual dysfunction (GI/GU/SD) symptoms following external-beam RT (EBRT) alone and treatments involving brachytherapy (BT±EBRT) for prostate cancer post-QUANTEC, and to ultimately perform quantitative syntheses of identified dose/volume tolerances represented by dose-volume histogram (DVH) thresholds, i.e., statistically significant (p≤0. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.08.015DOI Listing
August 2018
17 Reads

Rectal Trichomonas vaginalis infection in South African men who have sex with men.

Int J STD AIDS 2018 Aug 16:956462418788418. Epub 2018 Aug 16.

1 Anova Health Institute, Johannesburg, South Africa.

This study from South Africa highlights the importance of rectal Trichomonas vaginalis infection as a sexually transmitted infection among men who have sex with men (MSM). We report seven MSM presenting with rectal T. vaginalis infection. Read More

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http://dx.doi.org/10.1177/0956462418788418DOI Listing
August 2018
15 Reads

Two-year retrospective analysis of patients undergoing direct to procedure flexible sigmoidoscopy investigation with rectal bleeding as a primary complaint.

Endosc Int Open 2018 Aug 10;6(8):E1059-E1064. Epub 2018 Aug 10.

Gastrointestinal Diseases Research Unit (GIDRU), Department of Medicine, Queen's University, Kingston ON, Canada.

Background And Aims:  Rectal bleeding affects ~15 % of the general population and is a common reason for referral to gastroenterologists by primary care physicians. Direct to procedure flexible sigmoidoscopy is an appealing modality to investigate rectal bleeding due its diagnostic yield, safety profile, and accessibility. Patients referred on a routine basis for direct to procedure clinic by primary care physicians with the sole complaint of rectal bleeding have not previously been studied. Read More

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http://dx.doi.org/10.1055/a-0600-2157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086679PMC
August 2018
2 Reads

Short-term Toxicity of High Dose Rate Brachytherapy in Prostate Cancer Patients with Inflammatory Bowel Disease.

Clin Oncol (R Coll Radiol) 2018 Sep 30;30(9):534-538. Epub 2018 Jun 30.

Sussex Cancer Centre, Brighton & Sussex University Hospitals NHS Trust, Brighton, UK.

Aims: Inflammatory bowel disease (IBD) has historically been considered a risk factor for increased bowel toxicity in patients receiving pelvic external beam radiotherapy. The risk is reduced in intensity-modulated radiotherapy compared with three-dimensional conformal radiotherapy. The effect of brachytherapy has been less extensively researched. Read More

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http://dx.doi.org/10.1016/j.clon.2018.06.007DOI Listing
September 2018
3 Reads

Standard Chemoradiation and Conventional Brachytherapy for Locally Advanced Cervical Cancer: Is It Still Applicable in the Era of Magnetic Resonance-Based Brachytherapy?

J Glob Oncol 2018 Jul(4):1-9

All authors: Tata Memorial Centre, Navi Mumbai, India.

Purpose Recent guidelines recommend magnetic resonance imaging-based brachytherapy (MRBT) for locally advanced cervical cancer. However, its implementation is challenging within the developing world. This article reports the outcomes of patients with locally advanced cervical cancer treated with chemoradiation and point A-based brachytherapy (BT) using x-ray- or computed tomography-based planning. Read More

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http://dx.doi.org/10.1200/JGO.18.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223510PMC
July 2018
18 Reads

Malignant and Nonmalignant Complications of the Rectal Stump in Patients with Inflammatory Bowel Disease.

Inflamm Bowel Dis 2019 Jan;25(2):377-384

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands.

Background: Patients with refractory inflammatory bowel disease (IBD) might require a subtotal colectomy with construction of an ileostomy. Due to the risk of nerve damage and pelvic sepsis, the diverted rectum is often left in situ. Evidence on long-term complications of this rectal stump is limited, particularly in patients with Crohn's disease (CD). Read More

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http://dx.doi.org/10.1093/ibd/izy253DOI Listing
January 2019
3 Reads

Lymphogranuloma Venereum Proctitis.

Clin Gastroenterol Hepatol 2018 Aug 3. Epub 2018 Aug 3.

Gastroenterology Department, Amiens University Hospital, Amiens, France.

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http://dx.doi.org/10.1016/j.cgh.2018.06.019DOI Listing
August 2018
4 Reads