4,659 results match your criteria Proctitis

Establishing a rabbit model of perianal fistulizing Crohn's disease.

World J Gastroenterol 2022 Apr;28(15):1536-1547

Gastroenterology Center, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu Province, China.

Background: Crohn's disease (CD) is a chronic nonspecific intestinal inflammatory disease. The aetiology and pathogenesis of CD are still unclear. Anal fistula is the main complication of CD and is a difficult problem to solve at present. Read More

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Anorectal function with high resolution anorectal manometry in active ulcerative colitis and after remission: a pilot study.

Rev Recent Clin Trials 2022 May 13. Epub 2022 May 13.

Division of General, Mininvasive and Bariatric Surgery, University of Campania \'Luigi Vanvitelli\', Via Pansini 5, 80100, Naples, Italy.

Background: Ulcerative colitis may impair anorectal function, causing disabling symptoms such as incontinence and/or increase in stool frequency, urgency, and tenesmus. Data on anorectal function in these patients evaluated by conventional anorectal manometry are conflicting.

Objectives: The aim of this prospective study was to assess, by means of high resolution anorectal manometry, the anorectal function in patients with mild-to-moderate ulcerative colitis at presentation and after remission. Read More

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Factors Predictive of Proximal Disease Extension and Clinical Course of Patients Initially Diagnosed with Ulcerative Proctitis in an IBD Referral Center.

Turk J Gastroenterol 2022 Apr;33(4):320-328

Department of Medicine, University of São Paulo Ribeirão Preto Medical School, Brazil.

Background: This study aims to determine whether risk factors at the time of diagnosis that are found to be predictive of proximal dis- ease extension in ulcerative proctitis (UP) occur in a cohort of Brazilian patients.

Methods: This is a retrospective analysis of data from 97 patients (67% female) with UP (Montreal classification: E1) with at least 12 months of follow-up who were admitted to the Ribeirão Preto Medical School IBD referral center between January 2001 and December 2018. Proximal disease extension, which was defined as E1 progressing to E3 (pancolitis), was evaluated endoscopically during follow-up. Read More

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Getting to the bottom of persistent proctitis.

Intern Med J 2022 May;52(5):895-896

Gastroenterology Unit, Monash Health, Melbourne, Victoria, Australia.

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Investigation of HPLF-111624 in Modified Experimental Models of Ulcerative Proctitis and Anal Fissure in Rats.

J Exp Pharmacol 2022 27;14:149-165. Epub 2022 Apr 27.

Research and Development Center, Himalaya Wellness Company, Bengaluru, Karnataka, India.

Background: Although ulcerative proctitis (UP) and anal fissure (AF) are common anorectal diseases, there are no appropriate experimental models to screen the drugs intended for these conditions. In this context, existing experimental models mimicking these diseases were modified and the polyherbal formulation, HPLF-111624 was evaluated in these models.

Objective: To establish animal model for UP and AF and to evaluate polyherbal formulation, HPLF-111624 in these disease models. Read More

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[Infectious proctitis and perianal disease: a gaze beyond inflammatory bowel disease].

Rev Chilena Infectol 2021 Dec;38(6):820-823

Departamento de Infectología, Universidad de los Andes, Chile.

Infectious proctitis by sexually transmitted diseases are increasing in incidence and should be considered in homosexual patients with rectal symptoms. In this case, we show a patient with proctitis and perianal disease caused by Chlamydia trachomatis that could be diagnosed as another anorectal disease such as inflammatory bowel disease if the clinical history is not taken into account. A high level of suspicion is crucial, in order to avoid an incorrect diagnosis, delayed antibiotic therapy and the development of complications. Read More

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December 2021

Minimal risk of lymphoma and non-melanoma skin cancer despite long-term use of thiopurines in patients with inflammatory bowel disease: A longitudinal cohort analysis from northern India.

J Gastroenterol Hepatol 2022 May 2. Epub 2022 May 2.

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.

Background And Aim: Thiopurines are widely used to maintain remission in both ulcerative colitis (UC) and Crohn's disease (CD). Reported effectiveness and tolerability rates have been variable across studies. There are only sparse data in Asian population regarding the long-term efficacy and safety of thiopurines. Read More

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Comment on "The Effect of Hyperbaric Oxygen Therapy on Rectal Ulcers after Argon Plasma Coagulation".

GE Port J Gastroenterol 2022 Mar 3;29(2):80-81. Epub 2021 Nov 3.

Gastroenterology Department, Centro Hospitalar Universitário do Algarve, Portimão, Portugal.

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[Modern approaches to the rehabilitation of patients with chronic paraproctitis in the early postoperative period].

Vopr Kurortol Fizioter Lech Fiz Kult 2022 ;99(2):53-58

Petrovsky National Research Centre of Surgery, Moscow, Russia.

Along with the classical methods of surgical treatment of rectal fistulas, new minimally invasive technologies have appeared using video endoscopic support for processing the fistulous tract and closing the internal fistula opening, intrasphincter ligation of the fistulous tract LIFT, however, they do not exclude relapses in the late postoperative period. The FiLaC (Fistula Laser Closure) laser technology based on the use of a radial flexible laser light guide, which does not cause damage to the anal canal mucosa, pain in the postoperative period, rectal postoperative bleeding and strictures, is quite promising in the further development of outpatient minimally invasive surgery for anal fistulas. anal canal. Read More

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Therapeutic Potential of the 4-SURE Diet in Adults with Mild to Moderately Active Ulcerative Colitis: An Open Label Feasibility Study.

J Nutr 2022 Apr 22. Epub 2022 Apr 22.

Inflammatory Bowel Disease Services, The Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville South 5011, South Australia, Australia.

Background: Diet therapy may bridge the therapeutic gap in ulcerative colitis (UC).

Objectives: The novel 4-SURE diet (4-strategies-to-SUlfide-REduction), designed to modulate colonic fermentation and influence production of excess hydrogen sulfide, was examined in a feasibility study for tolerability, clinical efficacy and effects on microbial end-points.

Design: Adults ≥ 18 years old with mild to moderately active UC were advised to increase intake of fermentable fibers, restrict total and sulfur-containing proteins and avoid specific food additives for 8-weeks. Read More

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Enteric Infections in Men Who Have Sex With Men.

Clin Infect Dis 2022 Apr;74(Supplement_2):S169-S178

Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Enteric pathogens are often associated with exposure to food, water, animals, and feces from infected individuals. However, in sexual networks of men who have sex with men (MSM), transmission of enteric pathogens may occur during direct or indirect oral-anal contact.

Methods: We performed a scoping review of the literature for studies prior to July 2019 with key terms for gastrointestinal syndromes ("proctitis," "enteritis," "proctocolitis"), enteric pathogens or sexually transmitted infections (STIs), and outbreaks using multiple electronic databases. Read More

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Immunohistochemical detection of chlamydia trachomatis in sexually transmitted infectious proctitis.

BMC Gastroenterol 2022 Apr 8;22(1):171. Epub 2022 Apr 8.

Hospital Nacional Daniel A Carrión, Callao, Bellavista, Peru.

Introduction: Since 2003, a progressive increase in sexually transmitted infections (STI), presented as proctitis, has been described in homosexual men. In 2013 Arnold et al. described microscopic features that enable pathologists to formulate a histological diagnosis of STI related proctitis. Read More

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Tacrolimus (FK506) for induction of remission in corticosteroid-refractory ulcerative colitis.

Cochrane Database Syst Rev 2022 04 7;4:CD007216. Epub 2022 Apr 7.

National Institute of Health Research Nottingham Biomedical Research Centre, University of Nottingham and Nottingham University Hospitals, Nottingham, UK.

Background: There are a limited number of treatment options for people with corticosteroid-refractory ulcerative colitis. Animal models of inflammatory bowel disease and uncontrolled studies in humans suggest that tacrolimus may be an effective treatment for ulcerative colitis.

Objectives: To evaluate the efficacy and safety of tacrolimus for induction of remission in people with corticosteroid-refractory ulcerative colitis. Read More

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Non-empirical management of asymptomatic chlamydia and gonorrhoea reduces unnecessary antibiotic use fivefold: a before and after study.

Sex Transm Infect 2022 Apr 5. Epub 2022 Apr 5.

School of Population Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia.

Objectives: In 2019, informed by favourable patient and provider acceptability surveys and concerns about antimicrobial resistance, Sydney Sexual Health Centre stopped routinely providing empirical antibiotic treatment to asymptomatic contacts of (chlamydia) and (gonorrhoea). We aimed to assess if this policy change had any negative impact on patient outcomes.

Methods: A retrospective file review of people who presented as asymptomatic contacts of chlamydia and gonorrhoea cases before and after the policy change was conducted. Read More

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High dose rate brachytherapy in the management of anal cancer: A review.

Radiother Oncol 2022 Apr 4;171:43-52. Epub 2022 Apr 4.

Sunnybrook Health Sciences Centre, Toronto, Canada; University of Toronto, Toronto, Canada. Electronic address:

Purpose: To conduct a systematic review evaluating the impact of high dose rate (HDR) brachytherapy (BT) on the clinical outcomes and toxicities of patients with anal cancer.

Methods And Materials: A search of Medline, Embase, and Cochrane Library databases was performed using search terms: "anal", "anal canal", "squamous", "adenocarcinoma", "cancer", "neoplasm", in combination with "brachytherapy", "high dose rate brachytherapy" or "HDR brachytherapy". Additional studies were identified after scanning references. Read More

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Gonococcal endocarditis with aortic root abscess and severe aortic insufficiency.

IDCases 2022 15;28:e01474. Epub 2022 Mar 15.

Division of Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT, United States.

Gonorrhea caused by is a very common sexually transmitted infection in the United States and World-wide (Kirkcaldy et al., 2019) [1]. The population with highest prevalence is young sexually active adults aged 15-24 years. Read More

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First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists.

Int J STD AIDS 2022 Apr 18;33(5):456-461. Epub 2022 Mar 18.

WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, 98836Örebro University, Örebro, Sweden.

Background: Several lymphogranuloma venereum (LGV) outbreaks among men who have sex with men (MSM) have been reported throughout the world since 2003. Nevertheless, no LGV cases have been internationally reported from Russia. We evaluated the prevalence of LGV among MSM attending proctologists in Moscow, Russia, and compared the LGV and non-LGV rectal (CT) infections. Read More

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Anorectal pathology in the HIV population: a guide for radiologists.

Abdom Radiol (NY) 2022 05 14;47(5):1762-1774. Epub 2022 Mar 14.

Department of Radiology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH, 44106, USA.

Patients with human immunodeficiency virus (HIV) can present with a wide range of different acute and chronic pathologies. Anorectal conditions are particularly common in this unique patient population, including pathologies, such as proctitis, anorectal abscess, anorectal fistula, and anal squamous cell carcinoma. The radiologist plays a critical role in the assessment of these common forms of anorectal disease, as these conditions can present with various findings on imaging assessment. Read More

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A Novel Murine Model of a High Dose Brachytherapy-Induced Actinic Proctitis.

Front Oncol 2022 23;12:802621. Epub 2022 Feb 23.

Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.

Background: Radiation proctitis affects 1-20% of cancer patients undergoing radiation exposure due to pelvic malignancies, including prostate, gynecological and rectum cancers. The patients manifest rectal discomfort, pain, discharge, and bleeding. Notably, the efficacy of prophylactic measures remains controversial due to the lack of adequate animal models that mimic this condition. Read More

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February 2022

Study on Appropriate Rectal Volume for External Irradiation in Patients With Cervical Cancer.

Front Oncol 2022 22;12:814414. Epub 2022 Feb 22.

Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To investigate the appropriate rectal volume for external irradiation of cervical cancer.

Methods: A retrospective study of 143 patients with cervical cancer who underwent external radiotherapy from January 2017 to September 2020 was conducted. Average rectum volumes and the cumulative dose (V30, V40, V50, D2cc) to organs at risk (bladder, rectum, and small bowel) during radiotherapy were evaluated using the treatment planning system. Read More

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February 2022

[A case of ischemic proctitis caused by impaired venous blood flow 11 months after surgery for sigmoid colon cancer].

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(3):236-244

Department of Surgery, Saiseikai Matsusaka General Hospital.

A Japanese male in his 50s was presented to our hospital with the chief complaint of positive fecal immunochemical test. He had a history of hypertension. He underwent colonoscopy and was diagnosed with sigmoid colon cancer. Read More

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[Translated article] Sexually Transmitted Infections During the First Wave of the COVID-19 Pandemic in Spain.

Actas Dermosifiliogr 2022 Feb;113(2):T115-T122

Servicio de Dermatología Medicoquirúrgica y Venereología, Hospital Universitario La Paz, Madrid, Spain.

Objective: To describe changes in sexually transmitted infection (STI) diagnoses during the first wave of the COVID-19 pandemic in Spain.

Material And Methods: We collected demographic, chronological, and clinical data for all patients seen for a possible STI at Hospital La Paz, Centro Sanitario Sandaval, and Centro de Diagnóstico Médico in Madrid and Hospital Costa del Sol in Malaga between March 14, 2020 and June 30, 2020.

Results: We identified 674 STI diagnoses. Read More

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February 2022

Pre-operative high-dose-rate brachytherapy in early-stage cervical cancer: long-term single-center results.

J Contemp Brachytherapy 2022 Feb 19;14(1):43-51. Epub 2022 Jan 19.

Brachytherapy Department, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Poland.

Purpose: The aim of the study was to report the outcomes of pre-operative high-dose-rate brachytherapy (pHDR-BT), followed by hysterectomy in patients with early cervical cancer.

Material And Methods: From January, 1998 to December, 2003, 113 women with IB1, IB2, and IIA1 cervical cancer (according to International Federation of Gynecology and Obstetrics [FIGO] 2018) were treated with pHDR-BT, and 6 to 8 weeks later followed by radical hysterectomy. Patients found to have positive lymph nodes, residual cervical cancer, involved parametria, or lymphovascular space invasion (LVSI) received post-operative adjuvant therapy. Read More

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February 2022

Universal lymphogranuloma venereum (LGV) testing of rectal chlamydia in men who have sex with men and detection of asymptomatic LGV.

Sex Transm Infect 2022 Feb 25. Epub 2022 Feb 25.

Melbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia.

Background: Lymphogranuloma venereum (LGV) is caused by serovars L1-L3. This study determined the positivity for LGV testing before and after introduction of universal LGV testing of positive rectal samples in men who have sex with men (MSM).

Methods: From March 2015 to February 2018, MSM with rectal were not routinely tested for LGV at the Melbourne Sexual Health Centre unless they had HIV or symptoms of proctitis. Read More

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February 2022

Beverage Consumption and Ulcerative Colitis: A Case-Control Study from Saudi Arabia.

Int J Environ Res Public Health 2022 02 17;19(4). Epub 2022 Feb 17.

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

Background: The association between beverage intake and ulcerative colitis (UC) is not well-established, with no available data from Arab countries. Herein, we investigated the potential association of consuming coffee, tea, and carbonated soft drinks with UC among a population from Saudi Arabia.

Methods: This hospital-based case-control study used data of 171 newly diagnosed UC patients and 400 patients with other gastrointestinal conditions who served as controls. Read More

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February 2022

Stem Cell Injection for Complex Refractory Perianal Fistulas in Crohn's Disease: A Single Center Initial Experience.

Front Surg 2022 7;9:834870. Epub 2022 Feb 7.

Department of Surgery, Luigi Sacco University Hospital, University of Milan, Milan, Italy.

From 30 to 70% of patients with Crohn's disease (CD) may develop perianal fistulas during their lifetime. The medical and surgical management of this complication is challenging, and its treatment still gives unsatisfactory results. However, recent studies on adipose-derived mesenchymal stem cells have proven their anti-inflammatory and immuno-modulatory potential, representing a new promising tool in the treatment of such stubborn disease. Read More

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February 2022

IOIBD Recommendations for Clinical Trials in Ulcerative Proctitis: The PROCTRIAL Consensus.

Clin Gastroenterol Hepatol 2022 Feb 19. Epub 2022 Feb 19.

Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada.

Background & Aims: Clinical trials evaluating biologics and small molecules in patients with ulcerative colitis are predominantly excluding ulcerative proctitis. The objective of the Definition and endpoints for ulcerative PROCtitis in clinical TRIALs initiative was to develop consensus statements for definitions, inclusion criteria, and endpoints for the evaluation of ulcerative proctitis in adults.

Methods: Thirty-five international experts held a consensus meeting to define ulcerative proctitis, and the endpoints to use in clinical trials. Read More

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February 2022

Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium.

J Gastroenterol Hepatol 2022 Feb 17. Epub 2022 Feb 17.

Department of Medicine, University of Santo Tomas, Manila, Philippines.

Background And Aim: Inflammatory bowel disease (IBD) is emerging in the newly industrialized countries of South Asia, South-East Asia, and the Middle East, yet epidemiological data are scarce.

Methods: We performed a cross-sectional study of IBD demographics, disease phenotype, and treatment across 38 centers in 15 countries of South Asia, South-East Asia, and Middle East. Intergroup comparisons included gross national income (GNI) per capita. Read More

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February 2022

Evaluation of Implementation Effect of Cervical Cancer Comprehensive Treatment Patients With Whole-Course High-Quality Care Combined With Network Continuation Care.

Jing Chen Hui Bai

Front Surg 2022 31;9:838848. Epub 2022 Jan 31.

Department of Nephrology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Purpose: Discuss the implementation effect of cervical cancer comprehensive treatment patients applying whole-course high-quality care combined with network continuation care.

Methods: From August 2020 to August 2021, 120 patients who met the inclusion criteria for comprehensive treatment of cervical cancer were divided into the regular group ( = 60) who received conventional care and the joint group ( = 60) who received whole-course high-quality care combined with network continuation care, according to the method of care. The comprehensive treatment cognition level, comprehensive treatment compliance, adverse reaction rate, quality of life questionnaire (QLQ-C30) score, self-rating anxiety/depression scale (SAS/SDS) score, and nursing satisfaction were compared between the two groups. Read More

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January 2022