1,147,719 results match your criteria Process Biochemistry [Journal]


Percutaneous endoscopic gastrostomy in older patients with and without dementia: survival and ethical considerations.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background And Aim: Notwithstanding multiple recommendations in guidelines, percutaneous endoscopic gastrostomy (PEG)-tube placement is still performed in patients with dementia. In this study we aim to investigate survival in patients with and without dementia after (PEG)-tube placement.

Methods: We conducted a retrospective multicenter study in four different hospitals in The Netherlands. Read More

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December 2018

Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Cytometry A 2018 Dec;93(12):1213-1219

Faculty of the Heinrich-Heine, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, University Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany.

Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. Read More

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December 2018

Partial Costotransversectomy and Corpectomy for Thoracic Spinal Metastatic Disease: Operative Technique and Nuances: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurologic Surgery, Mayo Clinic Florida, Jacksonville, Florida.

We describe the operative approach and management for thoracic metastatic disease in a 78-yr-old man with worsening mechanical lower back and left-sided thoracic radicular pain. Imaging of the thoracic spine revealed an osteolytic T11 mass with destruction of the left T11 pedicle and transverse process. Biopsy confirmed spinal metastasis from the liver. Read More

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December 2018

Uromodulin in a pathway between decreased renal urate excretion and albuminuria.

Am J Hypertens 2018 Dec 14. Epub 2018 Dec 14.

Centre de recherche du CHUM, Montréal, Quebec, Canada.

Background: The mechanism explaining the inverse association between renal urate and albumin excretion remains unclear. First, we evaluated the impact of candidate variants in the main urate transporter genes (i.e. Read More

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December 2018

Pilot Studies of VOC Exposure Profiles during Surgical Operations.

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan, R.O.C.

Volatile organic chemical exposure resulting from surgical operations is common in operating room personnel. The potential risk of long-term exposure to these low-level chemicals is always a concern. This study was conducted in an area hospital located in northern Taiwan to investigate the internal exposure scenario for operating room personnel. Read More

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December 2018

Workplace Exposure to Nanoparticles during Thermal Spraying of Ceramic Coatings.

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain.

Thermal spraying is widely used for industrial-scale application of ceramic coatings onto metallic surfaces. The particular process has implications for occupational health, as the high energy process generates high emissions of metal-bearing nanoparticles. Emissions and their impact on exposure were characterized during thermal spraying in a work environment, by monitoring size-resolved number and mass concentrations, lung-deposited surface area, particle morphology, and chemical composition. Read More

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December 2018

Cytological and molecular aspects of the ageing sperm.

Hum Reprod 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Seminology - Sperm Bank 'Loredana Gandini' Department of Experimental Medicine, 'Sapienza' University of Rome, Italy.

Study Question: Is ageing associated with a decline in semen quality and molecular changes to human sperm?

Summary Answer: Semen quality declines with advancing age and characteristic molecular changes take place during the ageing process, including increased sperm DNA damage, altered sperm protamination and altered seminal plasma miRNA profile.

What Is Known Already: During ageing, the reproductive system is exposed to physiological changes and potentially damaging factors that may impair testicular function. Reactive oxygen species (ROS) can induce errors during DNA replication, transcription or post-transcriptional events (fragmentation, chromatin condensation abnormalities and protamine expression defects). Read More

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December 2018

Can mHealth improve timeliness and quality of health data collected and used by health extension workers in rural Southern Ethiopia?

J Public Health (Oxf) 2018 Dec;40(suppl_2):ii74-ii86

REACH Ethiopia, Hawassa, Ethiopia.

Background: Health extension workers (HEWs) are the key cadre within the Ethiopian Health Extension Programme extending health care to rural communities. National policy guidance supports the use of mHealth to improve data quality and use. We report on a mobile Health Management Information system (HMIS) with HEWs and assess its impact on data use, community health service provision and HEWs' experiences. Read More

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December 2018

Coupling interaction between porous biochar and nano zero valent iron/nano α-hydroxyl iron oxide improves the remediation efficiency of cadmium in aqueous solution.

Chemosphere 2018 Dec 7;219:493-503. Epub 2018 Dec 7.

College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China. Electronic address:

Based on the interaction between mesoscopic biochar materials and nanomaterials, the synergistic mechanism of the two materials in the process of cadmium remediation was studied. KCO activated porous biochar (KBC) loaded with nano-zero-valent iron (nZVI)/nano-α-hydroxy-iron oxide (nHIO) was studied. Macroscopically, batch adsorption experiments were carried out to describe the adsorption properties of the composites. Read More

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December 2018

Significant inhibition of photosynthesis and respiration in leaves of Cucumis sativus L. by oxybenzone, an active ingredient in sunscreen.

Chemosphere 2018 Dec 3;219:456-462. Epub 2018 Dec 3.

State Key Laboratory of Crop Biology, China; College of Life Sciences, Shandong Agricultural University, China. Electronic address:

Oxybenzone (OBZ), an active ingredient in most sunscreens, was recently shown to be toxic to humans, corals and other animals. This study is the first to demonstrate that OBZ can significantly inhibit photosynthesis and respiration in the leaves of a higher plant, cucumber. An OBZ suspension content as low as 0. Read More

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December 2018
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High-performance carbon/MnO micromotors and their applications for pollutant removal.

Chemosphere 2018 Dec 7;219:427-435. Epub 2018 Dec 7.

Institute of Environmental Engineering, ETH Zurich, Schafmattstrasse 6, 8093, Zurich, Switzerland; Advanced Analytical Technologies Laboratory, EMPA, Überlandstrasse 129, 8600, Dübendorf, Switzerland. Electronic address:

The wide applications of particulate micromotors in practice, especially in the removal of environmental pollutants, have been limited by the low production yields and demand on high concentration of fuel such as HO. Carbon/MnO micromotors were made hydrothermally using different carbon allotropes including graphite, carbon nanotube (CNT), and graphene for treatment of methylene blue and toxic Ag ions. The obtained micromotors showed high speed of self-propulsion. Read More

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December 2018
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Use of iron ore tailing from tailing dam as catalyst in a fenton-like process for methylene blue oxidation in continuous flow mode.

Chemosphere 2018 Dec 7;219:328-334. Epub 2018 Dec 7.

Reseacher at Federal University of Minas Gerais, Chemistry Department, Av. Pres. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, 31270-901, Brazil. Electronic address:

The global demand for iron ore with high iron contents to supply the steel industry is associated, in most countries, with the generation of tailings from mineral processing. The chemical compositions of iron ore tailings (basically FeO and SiO) make them an excellent candidate as a catalyst for advanced oxidation processes (AOPs), especially the Fenton process and its derivatives. Therefore, this paper aimed to transform iron ore tailings from tailing dams into catalysts able to activate HO for the purpose of treating, in a continuous flow, effluents contaminated with organic dyes, employing methylene blue as a model molecule. Read More

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December 2018
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Advances and opportunities for the design of self-sufficient and spatially organized cell-free biocatalytic systems.

Curr Opin Chem Biol 2018 Dec 11;49:97-104. Epub 2018 Dec 11.

Heterogeneous biocatalysis laboratory, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH-CSIC), University of Zaragoza, C/ Pedro Cerbuna 12, 50009, Zaragoza, Spain; ARAID, Aragon I+D foundation, Zaragoza, Spain. Electronic address:

During the past decades, biocatalysis has made important contributions to chemical manufacturing by using both whole-cell and cell-free biotransformation reactions. More recently, multi-enzyme systems that can run step-wise reactions in one-pot with high selectivity are increasingly being developed. The use of multiple isolated enzymes to perform a series of reactions offers operational and process advantages over the use of living or resting cells, but such cell free processes need to be optimized to meet industrial productivity and titer requirements. Read More

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December 2018
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Mobilising evidence to improve nursing practice: A qualitative study of leadership roles and processes in four countries.

Int J Nurs Stud 2018 Nov 27;90:21-30. Epub 2018 Nov 27.

School of Education, Health, and Social Studies, Dalarna University, Falun, Sweden.

Background: The approach and style of leaders is known to be an important factor influencing the translation of research evidence into nursing practice. However, questions remain as to what types of roles are most effective and the specific mechanisms through which influence is achieved.

Objectives: The aim of the study was to enhance understanding of the mechanisms by which key nursing roles lead the implementation of evidence-based practice across different care settings and countries and the contextual factors that influence them. Read More

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November 2018

Computational conformational analysis of α-thrombin inhibitors possessing distinct scaffolds in aqueous solution and on Ala-sheet.

Authors:
Keigo Gohda

J Mol Graph Model 2018 Dec 3;87:165-171. Epub 2018 Dec 3.

Computer-aided Molecular Modeling Research Center, Kansai (CAMM-Kansai), 3-32-302, Tsuto-Otsuka, Nishinomiya, 663-8241, Japan. Electronic address:

Recent computational simulations on protein-ligand binding/unbinding have precisely been uncovering the ligand-binding process at the atomic level. In the process, the non-specific binding of ligands to the target site is suggested to occur before binding to the target. We in this study analyzed the conformations of ligands under the non-specific binding on a protein surface to figure out the differences in the conformational characteristics in aqueous solution using the 55-ns molecular dynamic simulation. Read More

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December 2018

Investigating the physiological mechanisms underlying Salicornia ramosissima response to atmospheric CO enrichment under coexistence of prolonged soil flooding and saline excess.

Plant Physiol Biochem 2018 Dec 6;135:149-159. Epub 2018 Dec 6.

Departamento de Biología Vegetal y Ecología, Facultad de Biología, Universidad de Sevilla, 1095, 41080, Sevilla, Spain.

A 45-days long climatic chamber experiment was design to evaluate the effect of 400 and 700 ppm atmospheric CO treatments with and without soil water logging in combination with 171 and 510 mM NaCl in the halophyte Salicornia ramosissima. In order to ascertain the possible synergetic impact of these factors associate to climatic change in this plant species physiological and growth responses. Our results indicated that elevated atmospheric CO concentration improved plant physiological performance under suboptimal root-flooding and saline conditions plants. Read More

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December 2018

Vertico-horizontal atlantoaxial index (VHAI): A new craniovertebral radiographic index.

Clin Neurol Neurosurg 2018 Dec 3;176:83-88. Epub 2018 Dec 3.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Objective: The purpose of this study was to develop a new index that can reliably quantify the reduction of basilar invagination with atlantoaxial dislocation.

Patients And Methods: Between May 2012 and September 2017, 40 patients with congenital basilar invagination and atlantoaxial dislocation as well as 100 sex-and age-matched control subjects were recruited for this study. All patients underwent direct posterior reduction and fixation. Read More

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December 2018

Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design.

J Colloid Interface Sci 2018 Dec 4;538:559-568. Epub 2018 Dec 4.

Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; Department of Pharmacy, University of Uppsala, SE-75123 Uppsala, Sweden.

In an effort to contribute to research in scalable production systems for polymeric delivery systems loaded with antimicrobial peptides (AMPs), we here investigate effects of hydrodynamic flow conditions on microfluidic particle generation. For this purpose, rapid prototyping using 3D printing was applied to prepare micromixers with three different geometric designs, which were used to prepare Ca-cross-linked alginate microgels loaded with the AMP polymyxin B in a continuous process. Based on fluid dynamic simulations, the hydrodynamic flow patterns in the micromixers were designed to be either (i) turbulent with chaotic disruption, (ii) laminar with convective mixing, or (iii) convective with microvortex formation. Read More

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December 2018

National survey: Developing a common approach to grading of practice in pre-registration midwifery.

Nurse Educ Pract 2018 Nov 26;34:150-160. Epub 2018 Nov 26.

University College London, Gower St, Bloomsbury, London, WC1E 6BT, United Kingdom. Electronic address:

This paper presents the final phase of a national project exploring grading of practice in programmes leading to registration as a midwife in the United Kingdom. The aim was to develop a generic framework for grading practice, enhancing standardisation while enabling flexibility in application of current and new educational standards. A mixed method on-line survey considered existing practice assessment tools, factors contributing to robust and reliable assessment and perceptions of two assessment tools developed by the research team: a 'Lexicon Framework' and 'Rubric', which were tested through scenarios. Read More

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November 2018

Attentional bias modification reduces clinical depression and enhances attention toward happiness.

J Psychiatr Res 2018 Dec 1;109:145-155. Epub 2018 Dec 1.

Department of Psychology, The Third Military Medical University, Chongqing, 400038, China.

Difficulty in clinical antidepressant treatment leads to the pursuit of alternative treatments, such as cognitive-behavior therapy (CBT). CBT combined with regular antidepressants have indicated an optimal therapeutic effect in clinic. Attentional bias is important in the occurrence and remission of depression, however, few studies have explored the effect of attentional bias modification (ABM) on depression, and inconsistent results have been obtained due to the heterogeneity in the targeted populations, training tasks, strategies, and materials. Read More

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December 2018

Characterization of cytokine gene expression in uterine cytobrush samples of non-endometritic versus endometritic postpartum dairy cows.

Theriogenology 2018 Dec 5;126:128-139. Epub 2018 Dec 5.

Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, S7N 5B4, Canada.

To better understand uterine inflammation in postpartum dairy cows we collected sequential cytobrush samples at 29-35 and at 49-55 d in milk (DIM). Based on the uterine cytology, cows were classified as Non-endometritic (n = 23; <18% neutrophils) or Endometritic (n = 12; ≥18% neutrophils) at 29-35 DIM and Non-endometritic (n = 17; <10% neutrophils) or Endometritic (n = 9; ≥10% neutrophils) at 49-55 DIM. Cows defined as Sham Controls (n = 6) were examined by vaginoscopy at 29-35 DIM and identified as Non-endometritic (<10% neutrophils) at 49-55 DIM. Read More

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December 2018

Ln(III) chelates-functionalized carbon quantum dots: Synthesis, optical studies and multimodal bioimaging applications.

Colloids Surf B Biointerfaces 2018 Nov 22;175:272-280. Epub 2018 Nov 22.

State Key Laboratory of Environmental and Biological Analysis and Department of Chemistry, Hong Kong Baptist University, Waterloo Road, Hong Kong, China. Electronic address:

The carbon quantum dots termined with amine groups (CQDs-NH) were synthesized in one-pot hydrothermal method with citric acid as carbon source and branched polyethylenimine (BPEI) as passive agent, which was then covalently linked to 1, 4, 7, 10-tetraazacyclononane (DOTA) framework to yield CQDs-DOTA. The CQDs-DOTA provide excellent ligand scaffolds for the chelation of lanthanide ions, yielding the related complexes CQDs-DOTA-Ln (Ln = Eu, Tb, Yb and Gd). The successful preparation of CQDs-DOTA-Ln was validated by TEM, XRD, XPS, and FT-IR spectroscopy. Read More

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November 2018

Promoting opioid overdose prevention and recovery: An exploratory study of an innovative intervention model to address opioid abuse.

Int J Drug Policy 2018 Dec 11;64:21-29. Epub 2018 Dec 11.

NJ Division of Mental Health and Addiction Services, Office of Planning, Research, Evaluation and Prevention, 222 South Warren Street, Trenton, NJ 08625-0700, United States. Electronic address:

Background: Fatal opioid overdose is a national public health concern in the United States and a critical problem confronting New Jersey's addiction treatment system. New Jersey developed an innovative program, the Opioid Overdose Recovery Program (OORP), to address the epidemic and the issue of low treatment admissions following a non-fatal overdose. The OORP utilizes an intervention model with peer recovery specialists (RSs) and patient navigators (PNs) to engage individuals within emergency departments (EDs) immediately following an opioid overdose reversal. Read More

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December 2018

Near-infrared AIEgens as transformers to enhance tumor treatment efficacy with controllable self-assembled redox-responsive carrier-free nanodrug.

Biomaterials 2018 Dec 10;193:12-21. Epub 2018 Dec 10.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, PR China. Electronic address:

Nanosized drug delivery systems (nDDS) have been extensively exploited to achieve improved therapeutic performance of chemotherapeutic drugs in cancer treatment. Carrier-free nanodrugs have recently emerged as a promising generation of nDDS. In this work, a carrier-free theranostic nanodrug was fabricated by incorporating near-infrared (NIR) emission AIEgens (NPAPF) with redox responsive camptothecin-gemcitabine amphiphilic prodrug (CPT-ss-GEM) to form self-assembled nanoparticles (NCssG NPs). Read More

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December 2018

Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant.

Biomaterials 2018 Dec 10;193:1-11. Epub 2018 Dec 10.

Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address:

Mild heat stimulation can promote the restoration of bone defects but unfortunately, the delivery of exo-hyperthermy into human body is not efficient enough. In this study, mild heat-induced osteogenesis with high efficacy is demonstrated on an osteoimplant composed of black phosphorus nanosheets and poly(lactic-co-glycolic acid) (BPs@PLGA) with the participation of near-infrared (NIR) light irradiation. BPs@PLGA with only 0. Read More

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December 2018
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Rapid determination of 1,3-propanediol in fermentation process based on a novel surface-enhanced Raman scattering biosensor.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 28;211:227-233. Epub 2018 Nov 28.

Beijing Bioprocess Key Laboratory, Beijing University of Chemical Technology, Beijing 100029, PR China; College of Science, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:

The production of 1,3-propanediol (1,3-PDO) is an important fermentation process. However, 1,3-PDO could not be distinguished separately and efficiently in fermentations previously because it has a highly similar molecular structure to the feedstock glycerol (GLY) and by-product lactic acid (Lac), which leads to the difficulty of quantification. In this paper, a low-cost and environmentally friendly biosensor based on surface-enhanced Raman scattering (SERS) technique was developed. Read More

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November 2018

A comparative study of thermal stability of TNT, RDX, CL20 and ANTA explosives using UV 266nm-time resolved photoacoustic pyrolysis technique.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 6;211:212-220. Epub 2018 Dec 6.

Advanced Centre of Research in High Energy Materials (ACRHEM), University of Hyderabad, 500046, India. Electronic address:

The paper reports the potential use of UV based pulsed photoacoustic spectroscopy to study the thermal stability of some well-known premier explosives such as TNT, RDX, CL20, and ANTA between 30 and 350°C range. The thermal PA spectra of samples were recorded using fourth harmonic wavelength i.e. Read More

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December 2018

The effects of unintentional and intentional process disturbances on tablet quality during long continuous manufacturing runs.

Eur J Pharm Sci 2018 Dec 11. Epub 2018 Dec 11.

School of Pharmacy, Promis Centre, University of Eastern Finland, Kuopio, Finland. Electronic address:

Several kinds of process disturbances can occur during (continuous) tablet manufacturing, i.e. unintentional or intentional disturbances. Read More

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December 2018

Comparison and implementation of different control strategies for improving production of rHSA using Pichia pastoris.

J Biotechnol 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi, India. Electronic address:

Recombinant protein production by various host organisms is strictly regulated, which is determined mainly by host cell genetics and maintenance of process variables within desirable limits in a reactor. Since the process dynamics typically exhibit nonlinear interactions amongst the critical process variables, the commonly employed controllers are suboptimal for control of most bioprocesses. In this article, we present the implementation of an augmented controller for improving the production of recombinant human serum albumin using Pichia pastoris. Read More

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December 2018

International priorities for home care education, research, practice, and management: Qualitative content analysis.

Nurse Educ Today 2018 Dec 7;73:83-87. Epub 2018 Dec 7.

Case Western Reserve University, United States of America. Electronic address:

Background: Despite growing demand for home care nursing, there is a growing home care workforce shortage, due in part to hospital-centric nursing curricula that lead students to undervalue of home care and community practice setting (Van Iersel et al., 2018a, 2018b).

Objectives: Articulate an international vision for the future of home care education, research, practice, and management shared by experienced home care nurses working in leadership roles. Read More

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December 2018

Applying a population model based on hydrochemical parameters in wastewater-based epidemiology.

Sci Total Environ 2018 Nov 29;657:466-475. Epub 2018 Nov 29.

College of Environmental Science and Engineering, Dalian Maritime University, 1 Linghai Road, Dalian 116026, Liaoning, China. Electronic address:

Wastewater-based epidemiology combining with a population model based on hydrochemical parameters was applied in 10 wastewater treatment plants (WWTPs) in Jilin province, China. Population of WWTPs served was calculated by the model including three hydrochemical parameters ammonia nitrogen, chemical oxygen demand, and total phosphorus. The population model was constructed by using analytic hierarchy process to calculate weight factors of each hydrochemical parameters equivalent population. Read More

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November 2018

Uridine diphosphate release mechanism in O-N-acetylglucosamine (O-GlcNAc) transferase catalysis.

Biochim Biophys Acta Gen Subj 2018 Dec 11. Epub 2018 Dec 11.

The Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, People's Republic of China. Electronic address:

O-linked N-acetylglucosamine transferase (OGT) is an essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine (GlcNAc) to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions. Here, we determine the binding mode and the binding free energy of the OGT product (uridine diphosphate, UDP) as well as the hydrogen-bond-dependent release mechanism using extensive molecular dynamic simulations. Read More

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December 2018

Peptide antibiotic trichogin in model membranes: Self-association and capture of fatty acids.

Biochim Biophys Acta Biomembr 2018 Dec 11. Epub 2018 Dec 11.

Institute of Chemical Kinetics and Combustion, RAS, Novosibirsk 630090, Russian Federation; Novosibirsk State University, Novosibirsk 630090, Russian Federation. Electronic address:

The antimicrobial action of peptides in bacterial membranes is commonly related to their mode of self-assembling which results in pore formation. To optimize peptide antibiotic use for therapeutic purposes, a study on the concentration dependence of self-assembling process is thus desirable. In this work, we investigate this dependence for peptaibol trichogin GA IV (Tric) in the 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) model membrane in the range of peptide concentrations between 0. Read More

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December 2018

Dissecting the Thermodynamic Contributions of the Charged Residues in the Membrane Anchoring of Bcl-xl C-Terminal Domain.

Chem Phys Lipids 2018 Dec 11. Epub 2018 Dec 11.

Bioinformatics Centre, Bose Institute, P-1/12 C.I.T. Scheme VII M, Kolkata, 700054, India. Electronic address:

The C-terminal helix of the Bcl-xl is known to initiate the membrane insertion of the protein by anchoring into the mitochondrial outer membrane. The C-terminal charged residues of that helix, R232, and K233, are reported to have an important structural role in the process of insertion. The present work provides a quantitative understanding of the thermodynamic contribution of these residues on the membrane insertion profile from Adaptive Biasing Force based MD simulations of 2. Read More

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December 2018

Degradation Rate Observations as a Function of Drug Load in Solid State Drug Products.

J Pharm Sci 2018 Dec 11. Epub 2018 Dec 11.

Analytical Research & Development, Pfizer Inc, Sandwich, UK.

Degradation rates of solid state drug products generally increase as the drug load decreases. A model for quantifying this effect based on surface area ratios is proposed here. This model relates the degradation rate to an estimate of the proportion of drug substance in contact with the excipient, and that the drug substance in contact with excipients degrades more quickly. Read More

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December 2018

The role of neurogenesis in neurorepair after stroke.

Semin Cell Dev Biol 2018 Dec 11. Epub 2018 Dec 11.

Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address:

Stroke consists of an abrupt reduction of cerebral blood flow resulting in hypoxia that triggers an excitotoxicity, oxidative stress, and neuroinflammation. After the ischemic process, neural precursor cells present in the subventricular zone of the lateral ventricle and subgranular zone of the dentate gyrus proliferate and migrate towards the lesion, contributing to the brain repair. The neurogenesis is induced by signal transduction pathways, growth factors, attractive factors for neuroblasts, transcription factors, pro and anti-inflammatory mediators and specific neurotransmissions. Read More

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December 2018

Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice.

Nanomedicine 2018 Dec 11. Epub 2018 Dec 11.

Institute of Physiology II, University of Münster, Münster, Germany; Institute of Physiology, University of Lübeck, Lübeck, Germany. Electronic address:

Endothelial dysfunction is recognized as a critical condition in the development of cardiovascular disorders. This multifactorial process involves changes in the biochemical and mechanical properties of endothelial cells leading to disturbed release of vasoprotective mediators. Hypercholesterolemia and increased stiffness of the endothelial cortex are independently shown to result in reduced release of nitric oxide and thus endothelial dysfunction. Read More

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December 2018

miRNA networks modulate human endothelial cell adaptation to cyclic hypoxia.

Cell Signal 2018 Dec 11. Epub 2018 Dec 11.

Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland. Electronic address:

Solid tumor microenvironments are often subjected to various levels of hypoxia. Although regulation of gene expression has been examined extensively, most studies have focused on prolonged hypoxia. The tumor microenvironment, however, experiences waves of hypoxia and reoxygenation that stimulate the expression of pro-angiogenic factors that promote blood vessel formation. Read More

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December 2018

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment.

Int J Pharm 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability of raw materials from the drum till tablet, enabling the separation of non-confirming material. The proposed methodology addressed this leap in knowledge by characterizing materials, performing RTD trials according to an experimental design, applying RTD models and establishing a partial least square (PLS) regression model that links the material properties and process variables with the RTD responses as outputs. Read More

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December 2018

Vernal Keratoconjunctivitis.

Surv Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Vernal keratoconjunctivitis, a chronic, bilateral, seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases the disease is recurrent and leads to long-term visual disabling complications like keratoconus and limbal stem cell deficiency. The main pathogenic mechanism is IgE mediated; however, there may be non-IgE and certain non-specific hypersensitivity mechanisms. Read More

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December 2018

Random subspace-based ensemble modeling for near-infrared spectral diagnosis of colorectal cancer.

Anal Biochem 2018 Dec 11. Epub 2018 Dec 11.

Key Lab of Process Analysis and Control of Sichuan Universities, Yibin University, Yibin, Sichuan, 644000, China. Electronic address:

The feasibility of using near-infrared (NIR) spectroscopy coupled with classifier ensemble for improving the diagnosis of colorectal cancer was explored. A total of 157 NIR spectra from the patients were recorded and partitioned into the training set and the test set. Four algorithms, i. Read More

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December 2018

The cytochrome b lysine 329 residue is critical for ubihydroquinone oxidation and proton release at the Q site of bacterial cytochrome bc.

Biochim Biophys Acta Bioenerg 2018 Dec 11. Epub 2018 Dec 11.

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

The ubihydroquinone:cytochrome (cyt) c oxidoreductase (or cyt bc) is an important enzyme for photosynthesis and respiration. In bacteria like Rhodobacter capsulatus, this membrane complex has three subunits, the iron‑sulfur protein (ISP) with its FeS cluster, cyt c and cyt b, forming two catalytic domains, the Q (hydroquinone (QH) oxidation) and Q (quinone (Q) reduction) sites. At the Q site, the electron transfer pathways originating from QH oxidation are known, but their associated proton release routes are less well defined. Read More

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December 2018

Effects of Thinking Dispositions, General Ability, Numeracy, and Instructional Set on Judgments and Decision-Making.

Psychol Rep 2018 Dec 14:33294118806473. Epub 2018 Dec 14.

Effat University, Jeddah, Saudi Arabia.

To explore hypotheses based on Stanovich's proposal that analytic processing comprises a reflective-level, an algorithmic level, and specific mindware, 342 participants completed measures of thinking dispositions, general ability (GA), numeracy, and probabilistic and nonprobabilistic reasoning. In a control condition, numeracy predicted probabilistic reasoning at high levels of both thinking dispositions and GA, and GA predicted nonprobabilistic reasoning at high levels of thinking dispositions. In a logic instruction condition, numeracy predicted probabilistic reasoning when GA was high, and GA affected nonprobabilistic reasoning directly. Read More

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December 2018

The Role of Common Factors in Psychotherapy Outcomes.

Annu Rev Clin Psychol 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical, Neuro-, and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands; email:

Psychotherapies may work through techniques that are specific to each therapy or through factors that all therapies have in common. Proponents of the common factors model often point to meta-analyses of comparative outcome studies that show all therapies have comparable effects. However, not all meta-analyses support the common factors model; the included studies often have several methodological problems; and there are alternative explanations for finding comparable outcomes. Read More

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December 2018

Enhancing Electrochemical Efficiency of Hydroxyl Radical Formation on Diamond Electrodes by Functionalization with Hydrophobic Monolayers.

Langmuir 2018 Dec 14. Epub 2018 Dec 14.

Electrochemical formation of high-energy species such as hydroxyl radical in aqueous media is inefficient because oxidation of HO to form O is a more thermodynamically favorable reaction. Boron-doped diamond (BDD) is widely used as an electrode material for generating ∙OH radicals because it has a very large kinetic overpotential for O production, thus increasing electrochemical efficiency for ∙OH production. Yet, the underlying mechanisms of O and ∙OH production at diamond electrodes are not well understood. Read More

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December 2018

Predictable Electronic Tuning By Choice of Azine Substituent in Five Iron(II) Triazoles: Redox Properties and DFT Calculations.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

University of Otago, Chemistry, Union Place West, 9054, Dunedin , NEW ZEALAND.

Five new mononuclear iron(II) tris-ligand complexes, and four solvatomorphs, have been made from the azine-substituted 1,2,4-triazole ligands (Lazine): [FeII(Lpyridazine)3](BF4)2 (1), [FeII(Lpyrazine)3](BF4)2 (2), [FeII(Lpyridine)3](BF4)2 (3), [FeII(L2pyrimidine)3](BF4)2 (4), and [FeII(L4pyrimidine)3](BF4)2 (5). Single-crystal XRD and solid-state magnetometry reveal that all of them are low spin (LS) Fe(II), except for solvatomorph 5·4H2O. Evans method NMR studies in CD2Cl2, (CD3)2CO and CD3CN show that all are LS in these solvents, except 5 in CD2Cl2 (consistent with L4pyrimidine imposing the weakest field). Read More

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December 2018

Chirality Dependence of Amyloid β Cellular Uptake and a New Mechanistic Perspective.

Chembiochem 2018 Dec 14. Epub 2018 Dec 14.

UCSC, Chemistry and Biochemistry, 1156 High Street, 95064, Santa Cruz, UNITED STATES.

Amyloid β is an inherently disordered peptide that can form diverse neurotoxic aggregates, and its 42 amino acid long isoform is the believed culprit of Alzheimer's Disease. Cellular uptake of the peptide is a pivotal step for it to be able to exert many of its toxic actions. The cellular uptake process is complex, and numerous competing internalization pathways have been proposed. Read More

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December 2018
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The human visual system estimates angle features in an internal reference frame: A computational and psychophysical study.

J Vis 2018 Dec;18(13):10

Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.

Angle perception is an important middle-level visual process, combining line features to generate an integrated shape percept. Previous studies have proposed two theories of angle perception-a combination of lines and a holistic feature following Weber's law. However, both theories failed to explain the dual-peak fluctuations of the just-noticeable difference (JND) across angle sizes. Read More

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December 2018

Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment.

PLoS One 2018 14;13(12):e0209417. Epub 2018 Dec 14.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.

Uterine gland development, also known as adenogenesis, is a key uterine morphogenic process indispensable for normal uterine function and fertility. Our earlier studies have reported that overactivation of TGFB receptor 1 (TGFBR1) in the mouse uterus using progesterone receptor (Pgr)-Cre recombinase causes female infertility, defective decidualization, and reduced uterine gland formation, a developmental milestone of postnatal uterus. To understand mechanisms that underpin the disrupted uterine gland formation in mice with sustained activation of TGFBR1, we raised the question of whether early postnatal adenogenesis was compromised in these mice. Read More

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December 2018

Modular structure in fish co-occurrence networks: A comparison across spatial scales and grouping methodologies.

PLoS One 2018 14;13(12):e0208720. Epub 2018 Dec 14.

Department of Biology, Texas State University, San Marcos, Texas, United States of America.

Network modules are used for diverse purposes, ranging from delineation of biogeographical provinces to the study of biotic interactions. We assess spatial scaling effects on modular structure, using a multi-step process to compare fish co-occurrence networks at three nested scales. We first detect modules with simulated annealing and use spatial clustering tests (interspecific distances among species' range centroids) to determine if modules consist of species with broadly overlapping ranges; strong spatial clustering may reflect environmental filtering, while absence of spatial clustering may reflect positive interspecific relationships (commensalism or mutualism). Read More

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December 2018
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