52,981 results match your criteria Proceedings of the Institution of Mechanical Engineers. Part H Journal of engineering in medicine[Journal]


Late erythropoiesis-stimulating agents to prevent red blood cell transfusion in preterm or low birth weight infants.

Cochrane Database Syst Rev 2019 Feb 15;2:CD004868. Epub 2019 Feb 15.

Neonatal Intensive Care Unit, Neocare Hospital, Mumbai Naka, Nashik, Maharashtra, India, 422002.

Background: Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia. Darbepoetin (Darbe) and EPO are currently available ESAs.

Objectives: To assess the effectiveness and safety of late initiation of ESAs, between eight and 28 days after birth, in reducing the use of red blood cell (RBC) transfusions in preterm or low birth weight infants. Read More

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http://dx.doi.org/10.1002/14651858.CD004868.pub5DOI Listing
February 2019

Transcatheter arterial chemoembolisation followed by three-dimensional conformal radiotherapy versus transcatheter arterial chemoembolisation alone for primary hepatocellular carcinoma in adults.

Cochrane Database Syst Rev 2019 Feb 16;2:CD012244. Epub 2019 Feb 16.

Clinical Research Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 232 Waihuan Dong Road, Guangzhou, Guangdong, China, 510006.

Background: Hepatocellular carcinoma, also called malignant hepatoma, is a primary malignancy of the liver. Despite regular surveillance conducted in high-risk populations, most people with hepatocellular carcinoma are diagnosed at an advanced stage. Consequently, only a minority of people with the disease are suitable for surgical resection when diagnosed. Read More

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http://dx.doi.org/10.1002/14651858.CD012244.pub2DOI Listing
February 2019

Antibiotic treatment for newborns with congenital syphilis.

Cochrane Database Syst Rev 2019 Feb 15;2:CD012071. Epub 2019 Feb 15.

C/o Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, The University of Liverpool, First Floor, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, UK, L8 7SS.

Background: Congenital syphilis continues to be a substantial public health problem in many parts of the world. Since the first use of penicillin for the treatment of syphilis in 1943, which was a notable early success, it has remained the preferred and standard treatment including for congenital syphilis. However, the treatment of congenital syphilis is largely based on clinical experience and there is extremely limited evidence on the optimal dose or duration of administration of penicillin or the use of other antibiotics. Read More

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http://dx.doi.org/10.1002/14651858.CD012071.pub2DOI Listing
February 2019

When Daddy Stalks Mommy: Experiences of Intimate Partner Stalking and Involvement of Social and Legal Authorities When Stalker and Victim Have Children Together.

Violence Against Women 2019 Feb 18:1077801219826738. Epub 2019 Feb 18.

1 University of Southern Denmark, Odense, Denmark.

This study examined intimate partner stalking experienced by 196 mothers stalked by the father of their children. Respondents completed a questionnaire concerning experiences of stalking and level of support by the authorities. Results revealed higher rates of harassing than violent stalking. Read More

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http://dx.doi.org/10.1177/1077801219826738DOI Listing
February 2019

First Africa non-communicable disease research conference 2017: sharing evidence and identifying research priorities.

J Glob Health 2019 Jun;8(2):020301

East Africa NCD Alliance, Kampala, Uganda.

Non-communicable diseases (NCDs) prevalence is rising fastest in lower income settings, and with more devastating outcomes compared to High Income Countries (HICs). While evidence is consistent on the growing health and economic consequences of NCDs in sub-Saharan Africa (SSA), specific efforts aimed at addressing NCD prevention and control remain less than optimum and country level progress of implementing evidence backed cost-effective NCD prevention approaches such as tobacco taxation and restrictions on marketing of unhealthy food and drinks is slow. Similarly, increasing interest to employ multi-sectoral approaches (MSA) in NCD prevention and policy is impeded by scarce knowledge on the mechanisms of MSA application in NCD prevention, their coordination, and potential successes in SSA. Read More

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http://dx.doi.org/10.7189/jogh.09.010201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370979PMC

[Focused Abdominal Ultrasound in Emergency, Perioperative and Intensive Care Medicine].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Feb 15;54(2):128-141. Epub 2019 Feb 15.

The rising impact of perioperative sonography is mainly based on mobile high quality ultrasound systems. Relevant bleedings or functional limitations of the abdomen are easy to identify with sonography. The FAST-Concept can be the first access to continue proceedings in ultrasound examination of the abdomen. Read More

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http://dx.doi.org/10.1055/a-0585-5237DOI Listing
February 2019

Taxane-based chemohormonal therapy for metastatic hormone-sensitive prostate cancer: A Cochrane Review.

BJU Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Minnesota, Minneapolis, USA.

Objectives: Androgen deprivation therapy (ADT) has historically been the main management option for men with metastatic, hormone-sensitive prostate cancer. Over the last two decades, a number of agents have demonstrated a benefit in castration-resistant disease[1] and there has been interest to employ these drugs earlier in the disease course when the cancer is hormone-sensitive. Taxane-based chemotherapy has been utilized in such a manner and we aimed to assess the effects of early taxane-based chemohormonal therapy for newly diagnosed, metastatic, hormone-sensitive prostate cancer. Read More

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http://dx.doi.org/10.1111/bju.14711DOI Listing
February 2019

Developing strategic priorities in osteoarthritis research: Proceedings and recommendations arising from the 2017 Australian Osteoarthritis Summit.

BMC Musculoskelet Disord 2019 Feb 13;20(1):74. Epub 2019 Feb 13.

Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Australia.

Background: There is a pressing need to enhance osteoarthritis (OA) research to find ways of alleviating its enormous individual and societal impact due to the high prevalence, associated disability, and extensive costs.

Methods: Potential research priorities and initial rankings were pre-identified via surveys and the 1000Minds process by OA consumers and the research community. The OA Summit was held to decide key research priorities that match the strengths and expertise of the Australian OA research community and align with the needs of consumers. Read More

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http://dx.doi.org/10.1186/s12891-019-2455-xDOI Listing
February 2019

Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review.

Nutrients 2019 Feb 12;11(2). Epub 2019 Feb 12.

Royal Hallamshire Hospital and University of Sheffield, Sheffield S10 2RX, UK.

Celiac disease (CD) is an immune-mediated gastrointestinal disorder driven by innate and adaptive immune responses to gluten. Patients with CD are at an increased risk of several neurological manifestations, frequently peripheral neuropathy and gluten ataxia. A systematic literature review of the most commonly reported neurological manifestations (neuropathy and ataxia) associated with CD was performed. Read More

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http://www.mdpi.com/2072-6643/11/2/380
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http://dx.doi.org/10.3390/nu11020380DOI Listing
February 2019
1 Read

Aquablation of the prostate for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia.

Cochrane Database Syst Rev 2019 Feb 13;2:CD013143. Epub 2019 Feb 13.

Department of Urology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun, Korea, South.

Background: New, minimally invasive surgeries have emerged as alternatives to transurethral resection of the prostate (TURP) for the management of lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Aquablation is a novel, minimally invasive, water-based therapy, combining image guidance and robotics for the removal of prostatic tissue.

Objectives: To assess the effects of Aquablation for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia. Read More

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http://dx.doi.org/10.1002/14651858.CD013143.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373984PMC
February 2019

Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders.

Cochrane Database Syst Rev 2019 Feb 13;2:CD009824. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Melaka Manipal Medical College, Bukit Baru, Jalan Batu, Hampar, Melaka, Malaysia, 75150.

Background: Congenital bleeding disorders can cause obstetric haemorrhage during pregnancy, labour and following delivery. Desmopressin acetate (DDAVP) is found to be an effective drug which can reduce the risk of haemorrhage and can also stop bleeding in certain congenital bleeding disorders. Its use in pregnancy has been controversial. Read More

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http://dx.doi.org/10.1002/14651858.CD009824.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373982PMC
February 2019

Claims in total hip arthroplasty: analysis of the instigating factors, costs and possible solution.

Musculoskelet Surg 2019 Feb 13. Epub 2019 Feb 13.

1° Orthopaedic and Traumatology Unit, Department of Translational Research and New Technology in Medicine and Surgery, University Hospital of Pisa, Via Paradisa, 2, 56100, Pisa, Italy.

Purpose: Over the years, the number of total hip replacements has been steadily increasing. Despite the improvement in surgical results, the number of claims for malpractice is higher. The primary endpoint of this work is to provide an analysis of litigation after hip replacement, to outline what are the instigating causes and costs. Read More

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http://dx.doi.org/10.1007/s12306-019-00590-6DOI Listing
February 2019
1 Read

Competing Professional Knowledge Claims About Mental Capacity in the Court of Protection.

Authors:
Jaime Lindsey

Med Law Rev 2019 Feb 11. Epub 2019 Feb 11.

Essex Law School, University of Essex, Colchester, UK.

This article analyses the role of evidence in resolving Court of Protection proceedings, drawing on qualitative data obtained from observations of the Court of Protection, a review of Court of Protection case files and interviews with social workers. It is argued that there is a hierarchy of professional evidence in mental capacity law. Psychiatric evidence is at the top of this hierarchy, whereas social work evidence is viewed as a less persuasive form of knowledge about mental capacity. Read More

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http://dx.doi.org/10.1093/medlaw/fwz001DOI Listing
February 2019
1 Read

What Every Neuropathologist Needs to Know: Neuropathology and the US Legal System.

J Neuropathol Exp Neurol 2019 Feb 8. Epub 2019 Feb 8.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

The legal system of the United States is complex, with nuances that are particular to its many jurisdictions. The neuropathologist may professionally interact with the legal system in both criminal and civil proceedings as either a fact or expert witness, and in rare instances as a defendant. The nature of the legal issue at hand will define the pathologist's role and determine what actions are required or requested. Read More

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http://dx.doi.org/10.1093/jnen/nly131DOI Listing
February 2019

Nutrient-nutrient interactions: competition, bioavailability, mechanism and function in health and diseases.

Proc Nutr Soc 2019 02;78(1):1-3

Institute of Cardiovascular and Medical Sciences,College of Medical,Veterinary and Lifesciences,University of Glasgow,Glasgow G12 8TA,UK.

The Nutrition Society Spring Conference 2018, held in Glasgow, brought together experts focusing on the interaction between different nutrients and how this impacts absorption, metabolism and health from biochemical and physiological perspectives. This cross-cutting theme was examined from a range of perspectives, bringing together experts on topics ranging from food processing to the impact of inflammation on nutrient status. Two plenary lectures provided a food landscape and lifecourse background to the proceedings, with on the first day a focus on processed/ultra-processed foods and their nutrient composition and, on the second day, a plenary lecture exploring the role that nutrient-nutrient interactions within the maternal diet have for the lifelong health of the offspring. Read More

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http://dx.doi.org/10.1017/S0029665118002732DOI Listing
February 2019

Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders.

Cochrane Database Syst Rev 2019 Feb 12;2:CD010734. Epub 2019 Feb 12.

Office of the Chief Scientist, The George Institute for Global Health, University of New South Wales, Sydney, Australia.

Background: Iodine deficiency disorders (IDD) affect close to 1.9 billion people worldwide, and are a major public health concern in many countries. Among children, iodine deficiency is the main cause of potentially preventable deficits of central nervous system development and impairment of cognitive function, as well as goitre and hypothyroidism in people of all ages. Read More

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http://dx.doi.org/10.1002/14651858.CD010734.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370918PMC
February 2019
2 Reads

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link-a Workshop Summary Report.

AAPS J 2019 Feb 11;21(2):29. Epub 2019 Feb 11.

Pharmaceutical Sciences, Merck & Co., Inc., 770 Sumneytown Pike, WP75B-210, West Point, Pennsylvania, 19486-0004, USA.

This publication summarizes the proceedings of day 2 of a 3-day workshop on "Dissolution and Translational Modeling Strategies Enabling Patient-Centric Product Development." Patient-centric drug product development from a drug product quality perspective necessitates the establishment of clinically relevant drug product specifications via an in vitro-in vivo link. Modeling and simulation offer a path to establish this link; in this regard, physiologically based modeling has been implemented successfully to support regulatory decision-making and drug product labeling. Read More

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http://dx.doi.org/10.1208/s12248-019-0298-xDOI Listing
February 2019

Inappropriateness of health care in Canada: a systematic review protocol.

Syst Rev 2019 Feb 11;8(1):50. Epub 2019 Feb 11.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa, Canada.

Background: There is increasing recognition in Canada and globally that a substantial proportion of health care delivered is inappropriate as evidenced by (1) harmful and/or ineffective practices being overused, (2) effective clinical practices being underused, and (3) other clinical practices being misused. Inappropriate health care leads to negative patient experiences, poor health outcomes, and inefficient use of scarce health care resources. The purpose of this study is to conduct a systematic review of inappropriate health care in Canada. Read More

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http://dx.doi.org/10.1186/s13643-019-0948-1DOI Listing
February 2019
1 Read

A systematic review and meta-analysis of functional outcomes and complications following external fixation or open reduction internal fixation for distal intra-articular tibial fractures: an update.

Eur J Orthop Surg Traumatol 2019 Feb 9. Epub 2019 Feb 9.

Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark.

Purpose: To conduct a systematic review and meta-analysis comparing physical function and complications following DIATF surgery with external fixation (EF) or open reduction internal fixation (ORIF).

Method: A search was conducted using PubMed, Embase, Cochrane CENTRAL, Open Grey and Orthopaedic Proceedings. Studies with a level of evidence of I-III on patients (≥ 18 years) with DIATFs operated on with either EF or ORIF were included. Read More

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http://dx.doi.org/10.1007/s00590-019-02368-9DOI Listing
February 2019

Proceedings from the 8th Annual University of Calgary Leaders in Medicine Research Symposium.

Clin Invest Med 2019 Jan 30;41(4):E165-E185. Epub 2019 Jan 30.

Cumming School of Medicine University of Calgary, Calgary AB.

On November 14, 2016, the Leaders in Medicine (LIM) program at the Cumming School of Medicine, University of Calgary hosted its 8th Annual Research Symposium. Professor Stephen Sawcer, Professor of Neurological Genetics at the University of Cambridge and an Honorary Consultant Neurologist at Addenbrooke's Hospital, was the keynote speaker and presented a lecture entitled, "Multiple sclerosis genetics - prospects and pitfalls". This was not only a cutting edge address on genetics but also a thoughtful overview on Dr. Read More

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http://dx.doi.org/10.25011/cim.v41i4.32220DOI Listing
January 2019
1 Read

Antibiotics for induction and maintenance of remission in Crohn's disease.

Cochrane Database Syst Rev 2019 Feb 7;2:CD012730. Epub 2019 Feb 7.

Department of Medicine, University of Western Ontario, London, ON, Canada.

Background: Several antibiotics have been evaluated in Crohn's disease (CD), however randomised controlled trials (RCTs) have produced conflicting results.

Objectives: To assess the efficacy and safety of antibiotics for induction and maintenance of remission in CD.

Search Methods: We searched MEDLINE, Embase, CENTRAL, the Cochrane IBD Group Specialized Register and Clinicaltrials. Read More

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http://dx.doi.org/10.1002/14651858.CD012730.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366891PMC
February 2019
4 Reads

Diagnostic performance of optical coherence tomography angiography in glaucoma: a systematic review and meta-analysis.

Br J Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Community Medicine, Center for Health Technology and Services Research (CINTESIS), Information and Health Decision Sciences (MEDCIDS), University of Porto, Oporto, Portugal.

Background: Compared with current imaging methods, the diagnostic performance and the advantages and limitations of optical coherence tomography angiography (OCTA) remain unclear. We performed a systematic review and meta-analysis of studies investigating vessel density (VD) in patients with glaucoma using OCTA.

Methods: We conducted a literature search on PubMed, Scopus, Web of Science, ISI Conference Proceedings and Google Scholar, along with a manual search, from January 2006 to March 2018. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313461DOI Listing
February 2019

Ureteral stent versus no ureteral stent for ureteroscopy in the management of renal and ureteral calculi.

Cochrane Database Syst Rev 2019 Feb 6;2:CD012703. Epub 2019 Feb 6.

Department of Urology, University of Minnesota, 420 Delaware Street SE, MMC 394, Minneapolis, Minnesota, USA.

Background: Ureteroscopy combined with laser stone fragmentation and basketing is a common approach for managing renal and ureteral stones. This procedure is associated with some degree of ureteral trauma. Ureteral trauma may lead to swelling, ureteral obstruction, and flank pain and may require subsequent interventions such as hospital admission or secondary ureteral stent placement. Read More

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http://doi.wiley.com/10.1002/14651858.CD012703.pub2
Publisher Site
http://dx.doi.org/10.1002/14651858.CD012703.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365118PMC
February 2019
6 Reads

Musical instrument categorization is highly sensitive to spectral properties of earlier sounds.

Atten Percept Psychophys 2019 Feb 6. Epub 2019 Feb 6.

University of Louisville, 317 Life Sciences Building, Louisville, KY, 40292, USA.

Auditory perception is shaped by spectral properties of surrounding sounds. For example, when spectral properties differ between earlier (context) and later (target) sounds, this can produce spectral contrast effects (SCEs; i.e. Read More

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http://dx.doi.org/10.3758/s13414-019-01675-xDOI Listing
February 2019

Why Publish Scientific Meeting Proceedings?

Authors:
Adam Wanner

Chronic Obstr Pulm Dis 2018 Oct 10;5(4):231-232. Epub 2018 Oct 10.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida.

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https://journal.copdfoundation.org/jcopdf/id/1208/Why-Publis
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http://dx.doi.org/10.15326/jcopdf.5.4.2018.0159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361475PMC
October 2018
1 Read

Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO-AACR Research Workshop.

Clin Cancer Res 2019 Feb 5. Epub 2019 Feb 5.

Radiation Oncology, University of Texas MD Anderson Cancer Center

The development of cancers and their response to radiation are intricately linked to the tumor microenvironment in which they reside. Tumor cells, immune cells, and stromal cells interact with each other and are influenced by the microbiome and metabolic state of the host, and these interactions are constantly evolving. Stromal cells not only secrete extracellular matrix and participate in wound contraction, but they also secrete fibroblast growth factors (FGFs), which mediate macrophage differentiation. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3781DOI Listing
February 2019
1 Read

Guide and Proceedings of the International Union of Nutritional Sciences 21st International Congress of Nutrition Held in Buenos Aires, Argentina, 15-20 October 2017.

Adv Nutr 2019 Jan;10(suppl_1):S1-S3

CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

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http://dx.doi.org/10.1093/advances/nmy098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363525PMC
January 2019

Liquid Nitrogen Spray Cryotherapy in Treatment of Barrett's Esophagus, where do we stand? A Systematic Review and Meta-Analysis.

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Radiofrequency ablation (RFA) is the preferred treatment option for Barrett's esophagus (BE) to achieve complete eradication (CE) of dysplasia (D), and intestinal metaplasia (IM). Cryotherapy, using liquid nitrogen (LNC), is a cold-induced tissue-injury technique option for the ablation of BE. We conducted a systematic review and meta-analysis to assess the overall efficacy and safety of LNC in the treatment of BE. Read More

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http://dx.doi.org/10.1093/dote/doy130DOI Listing
January 2019

Colour stability of dental restorative materials submitted to conditions of burial and drowning, for forensic purposes.

J Forensic Odontostomatol 2018 Dec 1;2(36):20-30. Epub 2018 Dec 1.

Department of Dental Materials and Prosthodontics. Ribeirao Preto School of Dentistry - University of Sao Paulo, Brazil.

The aim of this study was to evaluate the effect of earth and water on the colour stability of tooth-coloured dental restorative materials: composite resin (CR) and glass ionomer cement (GIC). Aiming to distinguish between one and another tooth-coloured material and to estimate the period in which they could be submitted to the factors earth and water, the proposed method may contribute to the proceedings of human identification of victims of burial and submersion in water. Forty bovine incisors were prepared (6 x 6 x 2mm) and restored with CR FiltekTM Z250 XT (3M ESPETM) and GIC KetacTM Fil Plus (3M ESPETM). Read More

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December 2018
1 Read

The Values by Nicholas Markell.

Authors:
Margaret R Wentz

Mayo Clin Proc 2019 Feb;94(2):e35

Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.12.010DOI Listing
February 2019

Needle aspiration versus intercostal tube drainage for pneumothorax in the newborn.

Cochrane Database Syst Rev 2019 Feb 1;2:CD011724. Epub 2019 Feb 1.

Department of Paediatrics, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Pneumothorax occurs more frequently in the neonatal period than at any other time of life and is associated with increased mortality and morbidity. It can be treated with either aspiration with a syringe (using a needle or an angiocatheter) or a chest tube inserted in the anterior pleural space and then connected to a Heimlich valve or an underwater seal with continuous suction.

Objectives: To compare the efficacy and safety of needle aspiration (either with immediate removal of the needle or with the needle left in situ) to intercostal tube drainage in the management of neonatal pneumothorax (PTX). Read More

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http://doi.wiley.com/10.1002/14651858.CD011724.pub3
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http://dx.doi.org/10.1002/14651858.CD011724.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357997PMC
February 2019
9 Reads

Interventions to promote patient utilisation of cardiac rehabilitation.

Cochrane Database Syst Rev 2019 Feb 1;2:CD007131. Epub 2019 Feb 1.

School of Kinesiology and Health Science, York University, 4700 Keele Street, Toronto, Ontario, Canada, M4P 2L8.

Background: International clinical practice guidelines routinely recommend that cardiac patients participate in rehabilitation programmes for comprehensive secondary prevention. However, data show that only a small proportion of these patients utilise rehabilitation.

Objectives: First, to assess interventions provided to increase patient enrolment in, adherence to, and completion of cardiac rehabilitation. Read More

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http://doi.wiley.com/10.1002/14651858.CD007131.pub4
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http://dx.doi.org/10.1002/14651858.CD007131.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360920PMC
February 2019
2 Reads

Interventions for treating urinary incontinence after stroke in adults.

Cochrane Database Syst Rev 2019 Feb 1;2:CD004462. Epub 2019 Feb 1.

Faculty of Health and Wellbeing, University of Central Lancashire, Room 416, Brook Building, Preston, Lancashire, UK, PR1 2HE.

Background: Urinary incontinence can affect 40% to 60% of people admitted to hospital after a stroke, with 25% still having problems when discharged from hospital and 15% remaining incontinent after one year.This is an update of a review published in 2005 and updated in 2008.

Objectives: To assess the effects of interventions for treating urinary incontinence after stroke in adults at least one-month post-stroke. Read More

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http://doi.wiley.com/10.1002/14651858.CD004462.pub4
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http://dx.doi.org/10.1002/14651858.CD004462.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355973PMC
February 2019
3 Reads

Implementation of self-management support in cancer care and normalization into routine practice: a systematic scoping literature review protocol.

Syst Rev 2019 Jan 31;8(1):37. Epub 2019 Jan 31.

Faculty of Health Sciences, University of Southampton, Southampton, UK.

Background: Cancer survivors face a myriad of biopsychosocial consequences due to cancer and treatment that may be potentially mitigated through enabling their self-management skills and behaviors for managing illness. Unfortunately, the cancer system lags in its systematic provision of self-management support (SMS) in routine care, and it is unclear what implementation approaches or strategies work to embed SMS in the cancer context to inform health policy and administrator decision-making.

Methods/design: A comprehensive scoping review study of the literature will be conducted based on methods and steps identified by Arksey and O'Malley and experts in the field. Read More

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http://dx.doi.org/10.1186/s13643-019-0952-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354326PMC
January 2019

Aerobic physical exercise for adult patients with haematological malignancies.

Cochrane Database Syst Rev 2019 01 31;1:CD009075. Epub 2019 Jan 31.

Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Kerpener Str. 62, Cologne, Germany.

Background: Although people with haematological malignancies have to endure long phases of therapy and immobility, which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocytopenia from which many patients suffer. The inability to perform activities of daily living restricts them, diminishes their quality of life and can influence medical therapy. Read More

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http://dx.doi.org/10.1002/14651858.CD009075.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354325PMC
January 2019

The role of icodextrin in peritoneal dialysis: protocol for a systematic review and meta-analysis.

Syst Rev 2019 Jan 30;8(1):35. Epub 2019 Jan 30.

Institute for Research in Operative Medicine (IFOM), Department for Evidence Based Health Service Research, Faculty of Health, Department of Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, Building 38, 51109, Cologne, Germany.

Background: Previous meta-analyses have found several advantages of icodextrin compared with glucose in the application of peritoneal dialysis (PD), such as an improvement of peritoneal ultrafiltration during the long dwell and a reduction in episodes of uncontrolled fluid overload. However, the effect of icodextrin on patient-relevant outcomes remains unclear. This review aims to evaluate the benefits and harms of icodextrin in comparison with conventional glucose PD solution in patients with end-stage kidney disease receiving PD. Read More

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https://systematicreviewsjournal.biomedcentral.com/articles/
Publisher Site
http://dx.doi.org/10.1186/s13643-019-0959-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352378PMC
January 2019
3 Reads

AMCP Partnership Forum: Designing Benefits and Payment Models for Innovative High-Investment Medications.

Authors:

J Manag Care Spec Pharm 2019 Feb;25(2):156-162

High-investment medications, such as gene therapy and innovative specialty medications, offer breakthrough treatments that can greatly improve outcomes to patients with serious health conditions. However, many of these therapies are associated with significant costs that create barriers to patient access and affordability. Such innovative treatments have higher short-term costs, compared with current standards of care, but are anticipated to deliver substantial benefits that may persist over a long period of time, such as reduced mortality, improved health and quality of life, reduced health care costs, improved productivity, and reduced disability. Read More

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http://dx.doi.org/10.18553/jmcp.2019.25.2.156DOI Listing
February 2019

Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.

Cochrane Database Syst Rev 2019 Jan 30;1:CD009768. Epub 2019 Jan 30.

Systematic Review Initiative, NHS Blood and Transplant, Level 2, John Radcliffe Hospital, Headington, Oxford, Oxon, UK, OX3 9BQ.

Background: Recipients of allogeneic haematopoietic stem cell transplants (HSCT) can develop acute or chronic, or both forms of graft-versus-host disease (a/cGvHD), whereby immune cells of the donor attack host tissues. Steroids are the primary treatment, but patients with severe, refractory disease have limited options and a poor prognosis. Mesenchymal stromal cells (MSCs) exhibit immunosuppressive properties and are being tested in clinical trials for their safety and efficacy in treating many immune-mediated disorders. Read More

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http://dx.doi.org/10.1002/14651858.CD009768.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353308PMC
January 2019

Efficiency of bursectomy in patients with resectable gastric cancer: An updated meta-analysis.

Eur J Surg Oncol 2019 Jan 21. Epub 2019 Jan 21.

Department of Gastrointestinal Surgery, First Affiliated Hospital of Kunming Medical University, No. 1 School of Clinical Medicine, Kunming Medical University, No. 295 Xichang Road, Wuhua District, Kunming, Yunnan Province, 650031, China.

Aims: A meta-analysis was performed to evaluate the safety and efficiency of bursectomy for patients with gastric cancer.

Method: A literature search was performed in PubMed, EMBASE, and the Cochrane Library databases,China National Knowledge Infrastructure databases, China Science and Technology Journal(CSTJ) database and ASCO proceedings for clinical research that compared bursectomy with non-bursectomy published before July 2017. Operative time, blood loss, the number of dissected lymph nodes, complications, mortality, length of hospital stay, recurrence rate, overall survival and recurrence-free survival were compared using weighted mean differences(WMD) and relative risks(RR). Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.020DOI Listing
January 2019

Dissolution Testing in Drug Product Development: Workshop Summary Report.

AAPS J 2019 Jan 28;21(2):21. Epub 2019 Jan 28.

Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, 20993, USA.

This publication summarizes the proceedings and key outcomes of the first day ("Day 1") of the 3-day workshop on "Dissolution and Translational Modeling Strategies Enabling Patient-Centric Product Development." The overall aims of the workshop were to foster a productive dialog between industry and regulatory agencies and to discuss current strategies toward the development and implementation of clinically relevant dissolution specifications as an integral part of enhanced drug product understanding and effective drug product life-cycle management. The Day 1 podium presentations covered existing challenges and concerns for implementing highly valuable, yet often unique and novel experimental dissolution setups as quality control tools. Read More

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http://link.springer.com/10.1208/s12248-018-0288-4
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http://dx.doi.org/10.1208/s12248-018-0288-4DOI Listing
January 2019
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Prevalence of Listeria monocytogenes in Select Ready-to-Eat Foods-Deli Meat, Soft Cheese, and Packaged Salad: A Systematic Review and Meta-Analysis.

J Food Prot 2019 Feb;82(2):344-357

4 College of Veterinary Medicine, Iowa State University, Ames, Iowa 50010, USA.

Listeria monocytogenes is the cause of listeriosis, an important foodborne disease. Contaminated ready-to-eat foods are common sources of L. monocytogenes, yet no global estimates exist for prevalence and levels in high-risk ready-to-eat foods. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-158DOI Listing
February 2019

Topiramate for juvenile myoclonic epilepsy.

Cochrane Database Syst Rev 2019 01 28;1:CD010008. Epub 2019 Jan 28.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China, 100053.

Background: Topiramate is a newer broad-spectrum antiepileptic drug (AED). Some studies have shown the benefits of topiramate in the treatment of juvenile myoclonic epilepsy (JME). However, there are no current systematic reviews to determine the efficacy and tolerability of topiramate in people with JME. Read More

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http://doi.wiley.com/10.1002/14651858.CD010008.pub4
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http://dx.doi.org/10.1002/14651858.CD010008.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353083PMC
January 2019
4 Reads