39,493 results match your criteria Primitive Neuroectodermal Tumors


Gastric Ewing Sarcoma identified on a Meckel's scan.

Radiol Case Rep 2020 Aug 15;15(8):1235-1237. Epub 2020 Jun 15.

Department of Radiology, Phoenix Children's Hospital, 1919 E Thomas Rd. Phoenix, AZ 85016 USA.

Ewing Sarcoma is a malignant small round blue cell tumor most commonly found in bones and soft tissues of the axial skeleton and extremities. The Ewing family of tumors, including peripheral neuroectodermal tumor, represent the second most common malignancy in the pediatric population and second most common primary bone tumor after osteosarcoma. In a majority of Ewing Sarcoma cases, there is a translocation between chromosomes 11 and 22. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300240PMC

[Clinical effect of surgery combined with chemotherapy and radiotherapy in children with central primitive neuroectodermal tumor and prognostic analysis].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Jun;22(6):589-594

Department of Pediatrics, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing 100038, China.

Objctive: To study the clinical effect of surgery combined with chemotherapy and radiotherapy in children with central primitive neuroectodermal tumor (cPNET), as well as the risks factors for poor prognosis.

Methods: A retrospective analysis was performed for the clinical data of 42 children who were diagnosed with cPNET from June 2012 to September 2018.

Results: The 42 children had a median overall survival (OS) time of 2. Read More

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Challenges in the management of localized Ewing sarcoma in a developing country.

Pediatr Hematol Oncol 2020 Jun 19:1-10. Epub 2020 Jun 19.

Paediatric Haematology Oncology unit, Department of Paediatrics.

Survival in pediatric Ewing sarcoma (ES) lags in low- and middle-income countries (LMICs). This study analyzed factors contributing to a lower outcome in an LMIC center. A retrospective case review of children with localized ES treated from January 2011 till December 2017 was performed. Read More

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http://dx.doi.org/10.1080/08880018.2020.1772912DOI Listing

Intracranial Ewing Sarcoma - A case report.

Surg Neurol Int 2020 30;11:134. Epub 2020 May 30.

Department of Neurosurgery, St. George Public Hospital, Kogarah, New South Wales, Australia.

Background: Intracranial Ewing's sarcoma (ES) is a rare entity with <15 cases reported in the literature. It belongs to a family of round-cell neuroectodermally derived tumors bearing many similarities to peripheral primitive neuroectodermal tumor (pPNET). There is currently no established treatment protocol. Read More

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http://dx.doi.org/10.25259/SNI_178_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294174PMC

Metastatic Biphasic Primitive Tumor in the Mandible of a Child.

Eur J Dent 2020 Jun 15. Epub 2020 Jun 15.

Department of Pathology, Laboratório Bacchi Ltd., LB, Botucatu-SP, Brazil.

Pediatric mandibular tumors present an aggressive biological behavior and difficult diagnosis. A wide range of odontogenic and nonodontogenic tumors comprise the spectrum of these lesions. We report a case of a 1-year-old male child patient showing facial asymmetry symptomatic of an expansive lesion extending throughout the body and ramus of the left hemimandible with a diameter of 8 cm. Read More

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http://dx.doi.org/10.1055/s-0040-1713306DOI Listing

The effect of age distribution on the prognosis of retroperitoneal neuroblastoma.

Medicine (Baltimore) 2020 Jun;99(23):e20639

Department of Vascular Surgery, West China Hospital, Chengdu, China.

Retroperitoneal neuroblastoma is a rare subtype of neuroblastoma and the role of age in its clinical prognosis is still unknown.To describe the age distribution and investigate the association between age and survival outcomes in patients diagnosed with retroperitoneal neuroblastoma.We retrospectively analyzed patients registered for retroperitoneal neuroblastoma in the Surveillance, Epidemiology, and End Results (SEER) national database from 1973 to 2015. Read More

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http://dx.doi.org/10.1097/MD.0000000000020639DOI Listing

Giant primitive neuroectodermal pelvic tumour: a case report and literature review.

J Int Med Res 2020 Jun;48(6):300060520906747

Department of Orthopaedics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China.

Primitive neuroectodermal tumours (PNETs) are rare malignant small round cell tumours. Notably, despite widespread reports of PNET in multiple parts of the body, it is extremely rare in the pelvis. Here, a rare case of giant PNET of the pelvis, that was treated with surgical intervention comprising hemipelvectomy and amputation, is reported. Read More

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http://dx.doi.org/10.1177/0300060520906747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278316PMC

A case report of neonatal orbital peripheral primitive neuroectodermal tumor and literature review.

Eur J Ophthalmol 2020 Jun 3:1120672120926937. Epub 2020 Jun 3.

Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China.

Primitive neuroectodermal tumors are rare malignant neoplasms from primitive neural crest cells. Most primitive neuroectodermal tumors occur in the central and sympathetic nervous systems. We report a Chinese newborn patient presenting a huge unilateral proptosis after birth, diagnosed as orbital peripheral primitive neuroectodermal tumor by histopathology and immunohistochemistry. Read More

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http://dx.doi.org/10.1177/1120672120926937DOI Listing

[Neuroblastoma with the expression of cytokeratin: report of a case].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):628-630

Department of Pathology, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.

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http://dx.doi.org/10.3760/cma.j.cn112151-20191007-00543DOI Listing

A rare case of pelvic primitive neuroectodermal tumor with misleading symptoms: A case report.

Ann Med Surg (Lond) 2020 Jul 16;55:93-96. Epub 2020 May 16.

Department of Surgery, Aleppo University Hospital, University of Aleppo, Syria.

Peripheral Primitive NeuroEctodermal Tumors (pPNETs) are rare highly malignant tumors; originating from the neuroectoderm. Although PNETs may arise in various locations (most commonly in the extremities), very few cases have been reported in the pelvis. There is still poor evidence about the management of these tumors in the literature. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251491PMC

In vitro cytotoxicity of montelukast in HAPI and SH-SY5Y cells.

Chem Biol Interact 2020 Aug 25;326:109134. Epub 2020 May 25.

School of Pharmacy and Pharmacology, Griffith University, Queensland, 4222, Australia; Quality Use of Medicines Network, Queensland, Australia. Electronic address:

Montelukast is a cysteinyl leukotriene (CysLT) receptor antagonist with efficacy against a variety of diseases, including asthma and inflammation-related conditions. However, various neuropsychiatric events (NEs) suspected to be related to montelukast have been reported recently, with limited understanding on their association and underlying mechanisms. This study aimed to investigate whether montelukast can induce neuroinflammation and neurotoxicity in microglial HAPI cells and neural SH-SY5Y cells. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109134DOI Listing

Post-treatment FDG PET/CT predicts progression-free survival in young patients with small round blue cell tumors: Ewing sarcoma and PNET.

Eur J Radiol 2020 May 16;129:109076. Epub 2020 May 16.

Faculty of Medicine, University of Belgrade, Visegradska 26 St., 11000, Belgrade, Serbia; Center for Nuclear Medicine, Clinical Center of Serbia, Visegradska 26 St., 11000, Belgrade, Serbia. Electronic address:

Purpose: To determine if post-treatment F-18 FDG PET/CT results (overall positive findings, specific localizations) are independent predictors of disease progression in young patients with Ewing sarcoma and Primitive neuroectodermal tumor.

Method: A consecutive sample of 48 patients (age 14 ± 5 years, 32 male) was referred to F-18 FDG PET/CT for the suspected progression of Ewing sarcoma (39 patients) and Primitive neuroectodermal tumor (PNET) (9 patients) and followed-up clinically for 4.3 ± 2. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109076DOI Listing

Differentiation of Outcomes by Treatment Regimen and Histology in CNS Primary Embryonal Tumors.

World Neurosurg 2020 May 17. Epub 2020 May 17.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL. Electronic address:

Background: CNS embryonal tumors are malignant neoplasms of undifferentiated embryonic cells that typically occur in the pediatric population. They are further divided into many subgroups by distinct histological and genetic profiles. We present the largest-to-date study to identify differential survival outcomes within each subgroup by treatment regimen. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.103DOI Listing

Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database.

J Neurooncol 2020 Jun 19;148(2):281-290. Epub 2020 May 19.

Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden.

Objective: To investigate outcomes after surgery for rare brain tumors using the Swedish Brain Tumor Registry (SBTR).

Methods: This is a nationwide study of patient in the SBTR, validated in the Surveillance, Epidemiology, and End Results (SEER) registries. We included all adults diagnosed 2009-2015 with a rare brain tumor entity (n = 216), defined as ependymoma (EP, n = 64), subependymoma (SUBEP, n = 21), ganglioglioma (GGL, n = 54), pilocytic astrocytoma (PA, n = 56) and primitive neuroectodermal tumor (PNET, n = 21). Read More

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http://dx.doi.org/10.1007/s11060-020-03490-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316679PMC

Extraosseus Ewing's Sarcoma in Pancreas: A Review.

Cureus 2020 Apr 1;12(4):e7505. Epub 2020 Apr 1.

Internal Medicine, Chicago Medical School, Rosalind Franklin University, North Chicago, USA.

Primitive neuroectodermal tumors (PNET, previously referred to as peripheral neuroepithelioma) are rare malignant tumors with various degrees of differentiation belonging to the Ewing's family of sarcomas. They are classified as round cell tumors arising from soft tissues. In rare instances, PNETs may arise from solid organs containing neuroendocrine cells of kidney, bladder, heart, lungs, parotid glands and pancreas. Read More

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http://dx.doi.org/10.7759/cureus.7505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195206PMC

The Role of Predictive Model Based on Quantitative Basic Magnetic Resonance Imaging in Differentiating Medulloblastoma from Ependymoma.

Anticancer Res 2020 May;40(5):2975-2980

School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Background/aim: Even though advanced magnetic resonance imaging (MRI) can effectively differentiate between medulloblastoma and ependymoma, it is not readily available throughout the world. This study aimed to investigate the role of simple quantified basic MRI sequences in the differentiation between medulloblastoma and ependymoma in children.

Patients And Methods: The institutional review board approved this prospective study. Read More

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http://dx.doi.org/10.21873/anticanres.14277DOI Listing

Immunophenotype-Genotype Correlations in Clear Cell Sarcoma of Kidney-An Evaluation of Diagnostic Ancillary Studies.

Pediatr Dev Pathol 2020 May 4:1093526620910658. Epub 2020 May 4.

Trinity College, University of Dublin, Dublin, Ireland.

Introduction: The purpose of this study was to establish a reliable panel of antibodies for immunohistochemical corroboration of a diagnosis of clear cell sarcoma of kidney (CCSK), taking into consideration the various genotypic subsets of CCSK.

Methods: We conducted full genotypic analysis for evidence of internal tandem duplication (ITD), and in 68 archival cases of CCSK and then immunostained all cases for CCND1, TLE1, and BCOR along with 63 control samples representing tumor types that may enter into the differential diagnosis of CCSK, including 7 congenital mesoblastic nephromas, 2 desmoplastic small round cell tumors, 13 malignant rhabdoid tumors, 9 Ewing sarcomas/primitive neuroectodermal tumor, 5 synovial sarcomas, and 27 Wilms' tumors.

Results: Molecular assays showed that 54 CCSKs harbored a -ITD, 1 case expressed a fusion transcript while none expressed the fusion. Read More

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http://dx.doi.org/10.1177/1093526620910658DOI Listing

Pearls and Pitfalls in Interpretation of 68Ga-DOTATOC PET Imaging.

Clin Nucl Med 2020 Jun;45(6):e279-e280

From the Departments of Clinical Physiology, Nuclear Medicine, and PET.

DOTA-D-Phe-Tyr-octreotide labeled with Ga (Ga-DOTATOC) is the commonly used PET tracer for imaging meningioma because of its high affinity to somatostatin receptor subtype 2 (SSTR2) and an established imaging modality for planning radiation and radionuclide therapy. However, SSTR2 is not an exclusive marker for meningioma, and not all meningiomas express high levels of SSTR2. The SSTR2 expression has been reported in other intracranial tumors, for example, glioma, pituitary adenoma, medullablastoma, primitive neuroectodermal tumors, and hemangioblastoma leading to a significant risk of misinterpretation of PET/CT findings. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003012DOI Listing

Cerebral hemispheric glioblastoma with PNET-like morphology and histone H3.3 G34 mutation in younger patients: Report of three rare cases and diagnostic pitfalls.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):262-266

Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.

Recurrent mutations in H3F3A that encodes the histone 3 variant H3.3, lead to amino acid substitutions including K27M and G34R/V-which are observed in high-grade gliomas (HGGs) of children and young adults. Previous studies have focused on gliomas with K27M mutation, whereas gliomas with G34R/V mutation have received little attention. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_544_19DOI Listing

Germline Elongator mutations in Sonic Hedgehog medulloblastoma.

Nature 2020 04 1;580(7803):396-401. Epub 2020 Apr 1.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children, and genetic events that cooperate with known somatic driver events are poorly understood. Pathogenic germline variants in established cancer predisposition genes have been recently identified in 5% of patients with the malignant brain tumour medulloblastoma. Read More

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http://dx.doi.org/10.1038/s41586-020-2164-5DOI Listing

Long non-coding RNA DLX6-AS1 regulates neuroblastoma progression by targeting YAP1 via miR-497-5p.

Life Sci 2020 Jul 11;252:117657. Epub 2020 Apr 11.

Department of Pediatric surgical oncology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, PR China. Electronic address:

Aims: The lncRNA distal-less homeobox 6 antisense 1 (DLX6-AS1) has been reported to be an oncogenic lncRNA in diverse malignant cancers; however, whether it has oncogenic role in neuroblastoma(NB) remain largely unknown. This study explored the expression status, function and potential mechanism of DLX6-AS1 in NB.

Main Method: In the current study, a total of 70 human NB tissues and matched adjacent non-tumor tissues were collected. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117657DOI Listing

Clinical Significance of Segmental Chromosomal Aberrations in Patients with Neuroblastoma: First Report in Korean Population.

J Korean Med Sci 2020 Apr 13;35(14):e82. Epub 2020 Apr 13.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: This study aimed to investigate the incidence and clinical significance of segmental chromosomal aberrations (SCAs) in Korean patients with neuroblastoma.

Methods: Patients diagnosed with neuroblastoma from 2012 to 2018 were included for retrospective review. Fluorescence in situ hybridization (FISH) was used to analyze four SCAs ( amplification, 1p deletion, 11q deletion, and 17q gain). Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152533PMC

EWSR1(22q12) Translocation Positive Pediatric Adrenal Tumor with Loss of 1p, 11q, and Unbalanced Gain of 17q: Neuroblastoma or Ewing Sarcoma?

Fetal Pediatr Pathol 2020 Apr 3:1-6. Epub 2020 Apr 3.

Department of Pediatric Oncology, School of Medicine, Kocaeli University, Kocaeli, Turkey.

Although neuroblastoma and Ewing sarcoma/Primitive neuroectodermal tumor are different clinical entities, they are both a member of small round blue cell tumors and can mimic each other's behavior in clinical and molecular aspects. A 3 year-old girl with an abdominal mass was found to have a small round blue cell tumor originating from the right adrenal gland. High level of neuron specific enolase, initial genetic test results (N-Myc amplification: negative, loss of 1p, 11q, and unbalanced gain of 17q) and characteristic radiological appearance of the tumor suggested a preliminary diagnosis of neuroblastoma but further analysis showed CD99 expression and presence of EWSR1 rearrangement, which are mostly observed in Ewing sarcoma. Read More

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http://dx.doi.org/10.1080/15513815.2020.1745971DOI Listing

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil.

Int J Mol Sci 2020 Mar 25;21(7). Epub 2020 Mar 25.

College of Pharmacy, Roseman University of Health Sciences, 10530 Discovery Drive, Las Vegas, NV 89135, USA.

This study examined the biological activities of copaiba essential oil via measurement of its effects on signaling pathways in the SH-SY5Y neuronal cell line. Nanofluidic proteomic technologies were deployed to measure the phosphorylation of biomarker proteins within the signaling cascades. Interestingly, copaiba essential oil upregulated the pI3K/Akt/mTOR, MAPK, and JAK/STAT signaling pathways in neuronal cells. Read More

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http://dx.doi.org/10.3390/ijms21072259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177672PMC

[A comprehensive analysis of potential prognostic biomarkers for MYCN-amplified neuroblastoma].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Mar;22(3):262-268

Department of Pediatric Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China.

Objective: To study the differentially expressed mRNAs between MYCN-amplified neuroblastoma (NB) and non-amplified NB, to screen out the genes which can be used to predict the prognosis of MYCN-amplified NB, and to analyze their value in predicting prognosis.

Methods: NB transcriptome data and the clinical data of children were obtained from the TARGET database. According to the presence or absence of MYCN amplification, the children were divided into two groups: MYCN amplification (n=33) and non-MYCN amplification (n=121). Read More

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High CD44 expression is not a prognosis marker in patients with high-risk neuroblastoma.

EBioMedicine 2020 03 19;53:102702. Epub 2020 Mar 19.

Inserm U830, Institut Curie, PSL Research University, Equipe Labellisée Ligue contre le Cancer, Paris F-75005, France. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.102702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083781PMC

Response to "High CD44 expression is not a prognosis marker in patients with high-risk neuroblastoma".

EBioMedicine 2020 03 13;53:102703. Epub 2020 Mar 13.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla and Dpto. de Fisiología Médica y Biofísica, Universidad de Sevilla, IBiS. Avda. Manuel Siurot s/n, 41013 Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.102703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078286PMC

Role and toxicity of radiation therapy in neuroblastoma patients: A literature review.

Crit Rev Oncol Hematol 2020 May 3;149:102924. Epub 2020 Mar 3.

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China. Electronic address:

Neuroblastoma is the most common extracranial solid tumor, arising from primitive sympathetic ganglion cells, in pediatric patients. The unique features of neuroblastoma include variable clinical behaviors, such as rapid progression to death and maturation to benign ganglioneuroma, followed by regression. Radiation therapy (RT) is usually administered to both the primary tumor bed and persistent metastatic sites after induction chemotherapy for high-risk neuroblastoma. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102924DOI Listing
May 2020
4.027 Impact Factor

Pediatric Patients with Adrenal Neuroblastoma: A SEER Analysis, 2004-2013.

Am Surg 2020 Feb;86(2):127-133

Adrenal neuroblastoma (NB) is a relatively common malignancy in children. The Surveillance, Epidemiology, and End Results database was used to present demographic data and a survival analysis with the aim of making tumor management better. The Surveillance, Epidemiology, and End Results database was used to search pediatric patients (age ≤16 years) with NB from 2004 to 2013. Read More

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February 2020

[Exogenous HSP70 and Signaling Pathways Involved in the Inhibition of LPS-Induced Neurotoxicity of Neuroblastoma Cells].

Mol Biol (Mosk) 2020 Jan-Feb;54(1):128-136

Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290 Russia.

Neuroinflammation plays a key role in the pathogenesis of neurodegenerative diseases. Microglial cells are the main immune cells of the central nervous system. On exposure to lipopolysaccharides (LPS, components of the cell wall of Gram-negative enterobacteria), microglia is activated to produce reactive oxygen species (ROS), cytokines, and inflammatory mediators, which may cause neuron death. Read More

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http://dx.doi.org/10.31857/S0026898420010164DOI Listing

Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at "Prof. Dr. Ion Chiricuță" Institute of Oncology, Cluj-Napoca.

Diagnostics (Basel) 2020 Mar 5;10(3). Epub 2020 Mar 5.

PhD School Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Aim Of Study: The purpose of the study was to evaluate the association of thyroid dysfunction occurring in pediatric patients treated for brain tumors.

Patients And Methods: A total of 255 patients with brain tumors were treated between 2001 and 2018 at the "Prof. Dr. Read More

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http://dx.doi.org/10.3390/diagnostics10030142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151128PMC

Development and validation of a nomogram to predict the overall survival of patients with neuroblastoma.

Medicine (Baltimore) 2020 Mar;99(10):e19199

Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, China.

Neuroblastoma is the most prevalent malignancy in infants characterized by heterogeneous prognosis. It is critical to stratify the risks for patients with neuroblastoma. To stratify the risks for neuroblastoma, clinical characteristics of neuroblastoma patients were retrieved from the Therapeutically Applicable Research to Generate Effective Treatment program. Read More

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http://dx.doi.org/10.1097/MD.0000000000019199DOI Listing

Primary Peripheral Primitive Neuroectodermal Tumor of the Prostate on 18F-DCFPyL PET/CT.

Clin Nucl Med 2020 May;45(5):e249-e251

From the Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, China.

Peripheral primitive neuroectodermal tumor (PNET) is a group of malignant tumors composed of small round cells. Peripheral PNET usually originates in the skeletal system. However, the presence of PNET lesion in prostate is extremely rare. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002992DOI Listing

[WGCNA screening of prognostic markers in medulloblastoma].

Zhonghua Yi Xue Za Zhi 2020 Feb;100(6):460-464

Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China.

In this study, we used the Weighted gene co-expression network analysis (WGCNA) analysis to find the gene module that are specifically expressed in Medulloblastoma and screened the marker genes that may diagnose and treat Medulloblastoma. WGCNA was used to identify the gene modules that are specifically associated with suvival in Medulloblastoma. Cytoscape software was used to construct Co-expression Network. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2020.06.013DOI Listing
February 2020

Enhancing sustained-release local therapy: Single versus dual chemotherapy for the treatment of neuroblastoma.

Surgery 2020 06 28;167(6):969-977. Epub 2020 Feb 28.

Department of Surgery, Stanford University, CA. Electronic address:

Background: Neuroblastoma is the most common pediatric extracranial solid malignancy with limited effective treatment. We have shown that sustained-release, single drugs delivered locally through a silk-based biomaterial are effective in decreasing orthotopic neuroblastoma xenograft growth. We further optimized this approach and hypothesized that increasing doses of local chemotherapy or delivering 2 chemotherapeutic agents simultaneously inhibit additional tumor growth. Read More

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http://dx.doi.org/10.1016/j.surg.2020.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253329PMC

Management of Ewing Sarcoma Family of Tumors: A Short Description of a Rare Primitive Uterine pPNET and Literature Review.

Onco Targets Ther 2020 14;13:1179-1184. Epub 2020 Feb 14.

Department of Radiation Oncology, University of Naples Federico II, Naples, Italy.

Purpose: To describe the outcome of a patient with a rare primitive uterine pPNET and to perform a review of the available data in literature, leading the clinicians to better face this rare disease.

Methods: We have rescued data regarding the multidisciplinary treatment of pPNET from the PUBMED database, highlighting also issues regarding the pathogenesis and the genetic landscape of the ESFTs (Ewing Sarcoma Family of Tumors).

Results: Ewing sarcoma and primitive neuroectodermal tumors (PNETs) are small round cell tumors presenting with different degrees of neuroectodermal differentiation. Read More

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http://dx.doi.org/10.2147/OTT.S213233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034293PMC
February 2020
1.342 Impact Factor

Adrenocorticotropic Hormone-Secreting Esthesioneuroblastoma with Ectopic Cushing's Syndrome.

Yonsei Med J 2020 Mar;61(3):257-261

Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

Esthesioneuroblastoma as a source of ectopic Cushing's syndrome is rare, and to the best of our knowledge, only 20 cases have been reported worldwide. A 46-year-old healthy man visited a local clinic for general weakness and hyposmia, and underwent examination with serial endocrinological workup and brain imaging. Gallium-DOTA-TOC positron emission tomography scan was helpful where diagnosis of sellar MRI and inferior petrosal sinus sampling were discordant. Read More

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http://dx.doi.org/10.3349/ymj.2020.61.3.257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044685PMC

[Analysis of the effect of endoscopic surgery combined with conventional surgery in Neuroblastoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):128-130

Department of Otolaryngology Head and Neck Surgery,First Affiliated Hospital of Chinese Academy of Medical Sciences,Hefei,230001,China.

The aim of this study is to evaluate the efficacy of endoscopic surgery and conventional surgery combined with radiotherapy in the treatment of Neuroblastoma. Forty-three patients with olfactory neuroblastoma undergoing surgery combined with radiotherapy were retrospectively analyzed. The patients were divided into endoscopic surgery and conventional surgery. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2020.02.007DOI Listing
February 2020

High-risk neuroblastoma: where do we go?

Authors:
A Cañete

Ann Oncol 2020 03 25;31(3):326-327. Epub 2020 Jan 25.

Department of Paediatric Oncology, Hospital Universitari and Politecnic La Fe, Universitat de Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.annonc.2019.12.003DOI Listing

MYCN amplification and ATRX mutations are incompatible in neuroblastoma.

Nat Commun 2020 02 14;11(1):913. Epub 2020 Feb 14.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate with high-risk disease and poor prognosis. Here we show that ATRX mutations and MYCN amplification are mutually exclusive across all ages and stages in neuroblastoma. Read More

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http://dx.doi.org/10.1038/s41467-020-14682-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021759PMC
February 2020

Rare neural crest tumor in teleost species: olfactory neuroblastoma in a spotted pike-characin Boulengerella maculata.

Dis Aquat Organ 2020 02;138:29-33

Vancouver Aquarium and Marine Science Centre, Vancouver, BC V6G 3E2, Canada.

One spotted pike-characin Boulengerella maculata, managed in a public display aquarium for 7 yr, developed a small unilateral pink growth associated with the right nare. The growth eventually extended through both nares after 5 mo. B. Read More

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http://dx.doi.org/10.3354/dao03446DOI Listing
February 2020

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on spontaneous movement of human neuroblastoma cells.

Sci Total Environ 2020 May 18;715:136805. Epub 2020 Jan 18.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute of Environment and Health, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address:

Aryl hydrocarbon receptor (AhR) plays important roles in the interferences of dioxin exposure with the occurrence and development of tumors. Neuroblastoma is a kind of malignant tumor with high mortality and its occurrence is getting higher in dioxin exposed populations. However, there is still a lack of direct evidence of influences of dioxin on neuroblastoma cell migration. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.136805DOI Listing

Medulloblastoma cancer stem cells: molecular signatures and therapeutic targets.

J Clin Pathol 2020 May 7;73(5):243-249. Epub 2020 Feb 7.

Arkadi M Rywlin MD Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, Florida, USA

Medulloblastoma (MB) is the most common malignant primary intracranial neoplasm diagnosed in childhood. Although numerous efforts have been made during the past few years to exploit novel targeted therapies for this aggressive neoplasm, there still exist substantial hitches hindering successful management of MB. Lately, progress in cancer biology has shown evidence that a subpopulation of cells within the tumour, namely cancer stem cells (CSCs), are thought to be responsible for the resistance to most chemotherapeutic agents and radiation therapy, accounting for cancer recurrence. Read More

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http://dx.doi.org/10.1136/jclinpath-2019-206246DOI Listing
May 2020
2.915 Impact Factor

Expression pattern of EEF1A2 in brain tumors: Histological analysis and functional role as a promoter of EMT.

Life Sci 2020 Apr 4;246:117399. Epub 2020 Feb 4.

School of Biological Sciences, National Institute of Science Education and Research, HBNI, PO- Bhimpur- Padanpur, Jatni, Khurda 752050, Odisha, India. Electronic address:

Aims: Glioblastomas are highly aggressive brain tumors with a very poor survival rate. EEF1A2, the proto-oncogenic isoform of the EEF1A translation factor family, has been found to be overexpressed and promoting tumorigenesis in multiple cancers. Interestingly, recent studies reported reduced expression of this protein in brain tumors, drawing our attention to find the functional role and mechanism of this protein in brain tumor progression. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117399DOI Listing
April 2020
2.702 Impact Factor

Icariin inhibits proliferation, migration, and invasion of medulloblastoma DAOY cells by regulation of SPARC.

Authors:
Yan Yang Guifang Li

Phytother Res 2020 Mar 3;34(3):591-600. Epub 2020 Feb 3.

Department of Occupational Medicine, Weifang People's Hospital, Weifang, China.

Icariin (ICA) is obtained from Epimedium brevicornu maxim and exploited to remedy miscellaneous cancers. But the role of ICA in medulloblastoma remains hazy. The research delved into the antitumor activity of ICA in medulloblastoma DAOY cells. Read More

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http://dx.doi.org/10.1002/ptr.6545DOI Listing

[Classification of the types of pediatric posterior fossa brain tumors based on routine MRI using wavelet transformation analysis of whole tumor].

Zhonghua Yi Xue Za Zhi 2020 Jan;100(3):178-181

School of Biological Science and Medical Engineering, Southeast University, International laboratory for Children's Medical Imaging Research Nanjing, Nanjing 210096, China.

To evaluate the classification of the types of pediatric posterior fossa brain tumors based on routine MRI (T(1)WI, T(2)WI and ADC) using wavelet transformation analysis of whole tumor. MRI images of medulloblastoma (59), ependymoma (13) and pilocytic astrocytoma (27) confirmed by pathology before treatments in Children's Hospital of Nanjing Medical University from January 2014 to February 2019 were enrolled in this retrospective study as well as the clinical data of age, gender and symptoms. Registration was performed among the three sequences and wavelet features of ROI were acquired. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2020.03.004DOI Listing
January 2020

Modeling medulloblastoma in vivo and with human cerebellar organoids.

Nat Commun 2020 Jan 29;11(1):583. Epub 2020 Jan 29.

Armenise-Harvard Laboratory of Brain Cancer, Department CIBIO, University of Trento, Via Sommarive 9, 38123, Trento, Italy.

Medulloblastoma (MB) is the most common malignant brain tumor in children and among the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient-specific screen leading to the identification of Otx2 and c-MYC as strong Group 3 MB inducers. We validated our findings in human cerebellar organoids where Otx2/c-MYC give rise to MB-like organoids harboring a DNA methylation signature that clusters with human Group 3 tumors. Read More

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http://dx.doi.org/10.1038/s41467-019-13989-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989674PMC
January 2020

B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2.

Sci Rep 2020 Jan 27;10(1):1199. Epub 2020 Jan 27.

Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.

β-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) encodes the key enzyme B4GALNT1 to generate gangliosides GM2/GD2. GM2/GD2 gangliosides are surface glycolipids mainly found on brain neurons as well as peripheral nerves and skin melanocytes and are reported to exacerbate the malignant potential of melanomas. In order to elucidate the mechanism, we performed functional analyses of B4GALNT1-overexpressing cells. Read More

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http://dx.doi.org/10.1038/s41598-019-57130-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985110PMC
January 2020

Treatment of children under 4 years of age with medulloblastoma and ependymoma in the HIT2000/HIT-REZ 2005 trials: Neuropsychological outcome 5 years after treatment.

PLoS One 2020 23;15(1):e0227693. Epub 2020 Jan 23.

Department of Paediatric Haematology and Oncology, University Medical Centre, Hamburg-Eppendorf, Hamburg, Germany.

Young children with brain tumours are at high risk of developing treatment-related sequelae. We aimed to assess neuropsychological outcomes 5 years after treatment. This cross-sectional study included children under 4 years of age with medulloblastoma (MB) or ependymoma (EP) enrolled in the German brain tumour trials HIT2000 and HIT-REZ2005. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227693PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977734PMC