38,185 results match your criteria Primitive Neuroectodermal Tumors


The impact on outcomes by using thiotepa in tandem transplant for pediatric high-risk embryonal brain tumors.

J Chin Med Assoc 2019 Feb;82(2):148-154

Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

Background: Despite aggressive treatment including surgery, radiotherapy, and adjuvant chemotherapy, the outcome of pediatric high-risk embryonal brain tumors remains poor; especially in young children, in whom early radiotherapy inevitably brings significant long-term morbidities. Single or tandem autologous stem cell transplant has been reported to improve outcomes; but optimal use is not well defined.

Methods: Pediatric patients with high-risk embryonal brain tumors who underwent tandem transplant as consolidation from August 2011 to December 2017 were included. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000018DOI Listing
February 2019
1 Read

Multiple spinal intramedullary PNETs mimicking acute myelitis: a case report.

World Neurosurg 2019 Mar 1. Epub 2019 Mar 1.

Department of Radiology, Shaanxi Provincial People's Hospital. Electronic address:

Background: Primitive neuroectodermal tumors (PNETs) are rare malignant neoplasms in the spinal cord that comprise undifferentiated or poorly differentiated neural crest cells. PNETs imaging findings lack specificity, making diagnosis difficult.

Case Description: A 16-year-old man presented with progressive weakness and numbness of the lower extremities for 1 month, which occurred after a cold. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.108DOI Listing
March 2019
1 Read

[Neuropathology of medulloblastomas and other CNS embryonal tumors : Precision diagnostics through the integration of genetic markers].

Authors:
T Pietsch

Pathologe 2019 Mar;40(2):140-147

Institut für Neuropathologie, DGNN Hirntumor-Referenzzentrum, DZNE Deutsches Zentrum für Neurodegenerative Erkrankungen, Universität Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland.

The revised WHO classification of tumors of the central nervous system (CNS) in 2016 introduced the concept of the "integrated diagnosis." The definition of medulloblastoma entities now requires a combination of traditional histological information with additional molecular/genetic features. To define the histopathological component of the medulloblastoma diagnosis, tumors have to be assigned to one of the four histological entities: classic, desmoplastic/nodular (DNMB), extensive nodular (MBEN), or large cell/anaplastic (LC/A) medulloblastoma. Read More

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http://dx.doi.org/10.1007/s00292-019-0580-9DOI Listing
March 2019
1 Read

Primitive neuroectodermal tumor of kidney with Level III inferior vena cava thrombus.

Urol Ann 2019 Jan-Mar;11(1):105-108

Department of Urology and Renal Transplantation, SMS Medical College and Hospital, Jaipur, Rajasthan, India.

Primitive neuroectodermal tumor (PNET) of the kidney is an extremely rare renal neoplasm with only about 50 reported cases in the literature. These tumors behave aggressively and carry a poor prognosis. A 22 years female patient presented with right lumber and right hypochondrium lump of 4 months duration. Read More

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http://dx.doi.org/10.4103/0974-7796.250558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362795PMC
February 2019
1 Read

Peripheral Primitive Neuroectodermal Tumor of the Ovary: The Report of Two Rare Cases.

Iran J Pathol 2018 25;13(4):467-470. Epub 2018 Sep 25.

APCP, Dept. of Anatomical and Surgical Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Peripheral primitive neuroectodermal tumor (pPNET) is a highly aggressive small round cell tumor belonging to PNET/Ewing sarcoma family. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare. Herein we reported two cases of peripheral primitive neuroectodermal tumors of ovary in two patients with different clinical presentations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358556PMC
September 2018

Letter to the Editor Regarding "Combined Minimally Invasive Supraciliary and Transfacial Approach for Large Tumors with Skull Base and Sinonasal Involvement".

World Neurosurg 2019 02;122:707

Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, India.

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http://dx.doi.org/10.1016/j.wneu.2018.09.043DOI Listing
February 2019
1 Read

Next-generation whole exome sequencing of glioblastoma with a primitive neuronal component.

Brain Tumor Pathol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pathology and Laboratory Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Lake Success, 11042, NY, USA.

Glioblastoma with a primitive neuronal component (GBM-PN) was renamed from glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET) in the new WHO classification of tumors of the central nervous system in 2016. GBM-PN is a rare variant of glioblastoma. There were not so many publications on the investigation of GBM-PN. Read More

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http://link.springer.com/10.1007/s10014-019-00334-1
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http://dx.doi.org/10.1007/s10014-019-00334-1DOI Listing
February 2019
5 Reads

CAR-T cells : indications actuelles en pédiatrie et perspectives de développement.

Bull Cancer 2018 Dec;105 Suppl 2:S147-S157

Service d'Hématologie Pédiatrique, Hôpital Universitaire Robert Debré (APHP), 75019 Paris, France; Université Paris Diderot, 75010 Paris, France; EA 3518 Institut Universitaire d'Hématologie, 75010 Paris, France. Electronic address:

Car T Cells: CURRENT INDICATIONS IN CHILDREN AND PERSPECTIVES: Acute lymphoblastic leukemia (ALL) is the first cause of cancer in children. Five-year overall survival is greater than 90% but leukemia remains a major cause of death from cancer in children. A new class of immunotherapy based on a chimeric antigen receptor "CAR" targeting the CD19 on the B leukemic cells and that is transduced in an autologous or allogenic T lymphocyte will allow to transform the prognosis of refractory or relapsed B-ALL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00074551193004
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http://dx.doi.org/10.1016/S0007-4551(19)30045-1DOI Listing
December 2018
4 Reads

Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors.

Cancer Res 2019 Mar 23;79(5):905-917. Epub 2019 Jan 23.

Masonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.

: Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using () transposon mutagenesis, we identified novel genetic drivers of medulloblastoma and CNS-PNET. Cross-species gene expression analyses classified -driven tumors into distinct medulloblastoma and CNS-PNET subgroups, indicating they resemble human Sonic hedgehog and group 3 and 4 medulloblastoma and CNS neuroblastoma with activation. Read More

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-1261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397665PMC
March 2019
8 Reads

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.

Nat Commun 2019 01 18;10(1):332. Epub 2019 Jan 18.

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

Drugs that modify the epigenome are powerful tools for treating cancer, but these drugs often have pleiotropic effects, and identifying patients who will benefit from them remains a major clinical challenge. Here we show that medulloblastomas driven by the transcription factor Gfi1 are exquisitely dependent on the enzyme lysine demethylase 1 (Kdm1a/Lsd1). We demonstrate that Lsd1 physically associates with Gfi1, and that these proteins cooperate to inhibit genes involved in neuronal commitment and differentiation. Read More

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http://www.nature.com/articles/s41467-018-08269-5
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http://dx.doi.org/10.1038/s41467-018-08269-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338772PMC
January 2019
7 Reads

[Primary extra-osseous Ewing sarcoma of the dorsal spine with spinal cord compression at diagnosis: Case report].

Arch Argent Pediatr 2019 02;117(1):e41-e46

Grupo de Investigación en Salud del Adulto Mayor, Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Medellín. Colombia.

Extraosseous primitive neuroectodermal tumors are very rare neoplasms. Only a few cases have been published in the literature. This report is about a 9-year-old female patient whose clinical manifestations showed spinal cord compression, so different diagnosis should be considered, including oncology disease. Read More

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http://dx.doi.org/10.5546/aap.2019.e41DOI Listing
February 2019
5 Reads

Albumin binding, anticancer and antibacterial properties of synthesized zero valent iron nanoparticles.

Int J Nanomedicine 2019 28;14:243-256. Epub 2018 Dec 28.

Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,

Background: Nanoparticles (NPs) have been emerging as potential players in modern medicine with clinical applications ranging from therapeutic purposes to antimicrobial agents. However, before applications in medical agents, some in vitro studies should be done to explore their biological responses.

Aim: In this study, protein binding, anticancer and antibacterial activates of zero valent iron (ZVFe) were explored. Read More

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https://www.dovepress.com/albumin-binding-anticancer-and-ant
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http://dx.doi.org/10.2147/IJN.S188497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314318PMC
February 2019
9 Reads

Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum.

Curr Probl Diagn Radiol 2019 Jan 2. Epub 2019 Jan 2.

Department of Radiology, UW Medicine, Seattle, WA. Electronic address:

Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumor are part of a spectrum of neoplastic diseases known as the ES family of tumors, which also includes extraosseous ES, peripheral primitive neuroectodermal tumor, malignant small-cell tumor of the thoracopulmonary region (Askin's tumor), and atypical ES. Although imaging features of these tumors have been previously described, extensive discussion about intra-abdominal manifestations is scarce in the literature. We present an imaging spectrum of these tumors in the abdomen and pelvis with particular attention to multimodality approach for staging and restaging. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.12.009DOI Listing
January 2019
1 Read

[Brain tumors in children: about 136 cases].

Pan Afr Med J 2018 24;30:291. Epub 2018 Aug 24.

Service d'Anatomie Pathologique, CHU Mohammed VI, Hôpital Arrazi, Marrakech, Maroc.

Brain tumors are the most diagnosed solid tumors in children under the age of 15 years worldwide. However, the epidemiological and anatomopathological profile of these tumors has been poorly described in African and, particularly, in Moroccan literature. This study highlights the epidemiological and anatomopathological peculiarities of primary brain tumors in children living in the region of Marrakech (south Morocco). Read More

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http://www.panafrican-med-journal.com/content/article/30/291
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http://dx.doi.org/10.11604/pamj.2018.30.291.13208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317398PMC
January 2019
5 Reads

Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation.

Cancer Sci 2019 Mar 1;110(3):888-902. Epub 2019 Feb 1.

Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Dendritic cells (DC) play a key role in the initiation of both antitumor immunity and immunological tolerance. It has been demonstrated that exposure to soluble factors produced by tumor cells modulates DC functions and induces tolerogenic DC differentiation. In this study, we investigated the effects of neuroblastoma cell line-derived soluble factors on DC differentiation. Read More

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http://doi.wiley.com/10.1111/cas.13933
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http://dx.doi.org/10.1111/cas.13933DOI Listing
March 2019
8 Reads

Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.

Ewing's sarcoma (ES)/primitive neuroectodermal tumors (PNETs) are highly malignant neoplasms that usually affect the bones and soft tissues in children and young adults. ES/PNET of the lung is very rare and is associated with a poor prognosis. We herein report a case of ES/PNET of the left lung in a 45-year-old man. Read More

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http://dx.doi.org/10.2169/internalmedicine.1549-18DOI Listing
January 2019
4 Reads

Prognostic value of initial bone marrow disease detection by multiparameter flow cytometry in children with neuroblastoma.

J Cancer Res Clin Oncol 2019 Feb 2;145(2):535-542. Epub 2019 Jan 2.

Research Institute of Medical Cell Technologies, 22A, K. Marx st, Yekaterinburg, 620026, Russian Federation.

Purpose: Multicolor flow cytometry (MFC) is widely available, fast and has an easy-to perform approach for finding neuroblastoma (NB) cells among normal bone marrow (BM) hematopoietic cells. Aim of the study was to investigate prognostic significance of initial MFC tumor cells' detection in BM of children with NB.

Methods: 51 patients (24 boys and 27 girls) aged from 6 days to 15 years (median age 1 year 3 months) with NB were included in the study. Read More

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http://dx.doi.org/10.1007/s00432-018-02831-wDOI Listing
February 2019
2 Reads

Cervicomedullary primitive neuroectodermal tumor of the spine: Case report.

Surg Neurol Int 2018 28;9:241. Epub 2018 Nov 28.

Department of Internal Medicine, Hospital São Francisco, Ribeirão Preto, São Paulo, Brazil.

Background: Intramedullary primitive neuroectodermal tumors (PNETs) are tumors found rarely in the cervical region, with only five such cases described in the literature. The available literature contains only one report regarding cervicomedullary junction PNET.

Case Description: The authors present a case report of a 45-year-old male patient who had undergone urgent hospitalization owing to progressive tetraparesis and subtle impairment of respiratory function. Read More

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http://dx.doi.org/10.4103/sni.sni_41_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287338PMC
November 2018
2 Reads

Peripheral primitive neuroectodermal tumor associated with paraneoplastic Cushing's syndrome: The rare case.

Ann Med Surg (Lond) 2019 Jan 29;37:21-24. Epub 2018 Nov 29.

Iran University of Medical Science, Tehran, Iran.

Introduction: Primitive neuroectodermal tumors (PNET) form a group of tumors defined by their appearance that are thought to develop from primitive (undifferentiated) nerve cells in the brain. They are rare tumors and their incidence is not well defined.

Case Presentation: An 18-month-old male presenting with typical Cushingoid appearance (moon face, central obesity, hirsutism and growth arrest) was admitted for evaluation of endocrine problems. Read More

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http://dx.doi.org/10.1016/j.amsu.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287080PMC
January 2019
1 Read

Intraneural Ewing Sarcoma of Fibular Nerve: Case Report, Radiologic Findings and Review of Literature.

World Neurosurg 2019 Mar 20;123:212-215. Epub 2018 Dec 20.

Neurosurgery Unit, Department of Neurosciences, University of Turin, Turin, Italy.

Background: Intraneural Ewing sarcoma (ES) was first described in 1918 by Stout in a tumor of the ulnar nerve. These tumors are in the category of ES family of tumors, together with ES of bone, extraosseous ES, and primitive neuroectodermal tumor. ES typically occurs in the second decade of life; only 20% of cases affect elder people. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.043DOI Listing
March 2019
6 Reads

Adult neuroblastoma in the retroperitoneum: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13750

Department of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou.

Rationale: Neuroblastoma is the most common extracranial malignant solid tumor that occurs during childhood. It arises from primitive cells and is found in the adrenal medulla and sympathetic ganglia of the sympathetic nervous system. Huge neuroblastoma in the retroperitoneum, especially adult involvement is extremely rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000013750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320202PMC
December 2018
15 Reads

Primary spinal primitive neuroectodermal tumor: A single center series with literature review.

J Spinal Cord Med 2018 Dec 18:1-9. Epub 2018 Dec 18.

a Department of Neurosurgery , Beijing Tiantan Hospital affiliated to Capital Medical University , Beijing , People's Republic of China.

Context: Primary spinal primitive neuroectodermal tumor (PNET) of the central nervous system has a low incidence. The intraspinal case is very rare. Around 30 cases have been reported so far. Read More

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https://www.tandfonline.com/doi/full/10.1080/10790268.2018.1
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http://dx.doi.org/10.1080/10790268.2018.1547862DOI Listing
December 2018
14 Reads
1.878 Impact Factor

Surgical removal of adult recurrent neuroblastoma located in the posterior mediastinum and retroperitoneum: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13642

Department of Hepatobiliary Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.

Rationale: Adult recurrent neuroblastoma is extremely rare, especially in the posterior mediastinum and retroperitoneal cavity. The surgical treatment of this special part of the tumor is also a clinical difficulty.

Patient Concerns: This study reports a case of a 24-year-old man with a history of treated posterior mediastinal neuroblastoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320002PMC
December 2018
1 Read

Neuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases.

Am J Surg Pathol 2019 Mar;43(3):422-431

Departments of Pathology.

Overgrowth of neuroglial tissue is rare in testicular germ cell tumors and mostly reported as isolated cases. We retrospectively reviewed 13 cases of testicular germ cell tumors from 2 institutions from 1995 to 2018. Hematoxylin and eosin slides were collected and reviewed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001206DOI Listing
March 2019
4 Reads

Influence of glucose transporter 1 activity inhibition on neuroblastoma in vitro.

Gene 2019 Mar 13;689:11-17. Epub 2018 Dec 13.

Department of Physiology, Chongqing Medical University, Chongqing 400016, China; Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Most cancer cells predominantly produce their energy through a high rate of glycolysis in the presence of abundant oxygen. Glycolysis has become a target of anticancer strategies. Previous researches showed that glucose transporter 1 (GLUT1) inhibitor is effective as anticancer agents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119183125
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http://dx.doi.org/10.1016/j.gene.2018.12.010DOI Listing
March 2019
14 Reads

Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.

Nat Commun 2018 12 14;9(1):5331. Epub 2018 Dec 14.

Posttranscriptional Gene Regulation, Cancer Research and Experimental Haemostasis, University Medical Centre Mainz, Mainz, 55131, Germany.

Diversification at the transcriptome 3'end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive transcriptome 3'end-alterations in neuroblastoma, a tumour entity with a paucity of recurrent somatic mutations and an unusually high frequency of spontaneous regression. Utilising extensive RNAi-screening we reveal the landscape and drivers of transcriptome 3'end-diversification, discovering PCF11 as critical regulator, directing alternative polyadenylation (APA) of hundreds of transcripts including a differentiation RNA-operon. Read More

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http://dx.doi.org/10.1038/s41467-018-07580-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294251PMC
December 2018
12 Reads

Downregulation of EIF5A2 by miR-221-3p inhibits cell proliferation, promotes cell cycle arrest and apoptosis in medulloblastoma cells.

Biosci Biotechnol Biochem 2019 Mar 14;83(3):400-408. Epub 2018 Dec 14.

a Department of Neurosurgery , The First Affiliated Hospital of Yangtze University , Jingzhou , Hubei Province , China.

Recently, miR-221-3p expression has been reported to be down-regulated in medulloblastoma (MB), but its functional effects remains unclear. In this study, quantitative real-time PCR (qRT-PCR) revealed significantly decreased miR-221-3p in MB cell lines. Transfection of miR-221-3p mimics reduced, or inhibitor increased cell proliferation in MB cells using MTT assay. Read More

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https://www.tandfonline.com/doi/full/10.1080/09168451.2018.1
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http://dx.doi.org/10.1080/09168451.2018.1553604DOI Listing
March 2019
10 Reads

A mechanistic classification of clinical phenotypes in neuroblastoma.

Science 2018 12;362(6419):1165-1170

Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. Read More

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http://www.sciencemag.org/lookup/doi/10.1126/science.aat6768
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http://dx.doi.org/10.1126/science.aat6768DOI Listing
December 2018
17 Reads

Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.

Med Sci Monit 2018 Dec 12;24:9007-9018. Epub 2018 Dec 12.

Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China (mainland).

BACKGROUND Acyl-coenzymeA: cholesterol acyltransferase (ACAT) 1, a key enzyme converting excess free cholesterol to cholesterol esters, has been demonstrated to be associated with the pathogenesis of Alzheimer disease (AD). However, the mechanism underlying the protective role of ACAT1 blockage in AD progression remains elusive. MATERIAL AND METHODS Human neuroblastoma SH-SY5Y cells were treated for 24 h with increasing concentrations of aggregated Aβ₂₅₋₃₅ (5, 15, 25, and 45 μmol) with or without the ACAT1 siRNA pretreatment. Read More

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http://dx.doi.org/10.12659/MSM.912862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299791PMC
December 2018
2 Reads

Comparison of clinical features and outcomes in patients with extraskeletal vs skeletal Ewing sarcoma: an SEER database analysis of 3,178 cases.

Cancer Manag Res 2018 23;10:6227-6236. Epub 2018 Nov 23.

Department of Medical Oncology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China,

Background: The clinicopathological characteristics, outcomes and prognostic factors of primary extraskeletal Ewing sarcoma (EES) remained insufficiently explored. We aimed to examine these aspects and compared the same with skeletal Ewing sarcoma (SES).

Patients And Methods: We identified Ewing sarcoma, peripheral primitive neuroectodermal tumors or Askin tumor patients who were registered in the Surveillance, Epidemiology, and End Results database from 1973 to 2014. Read More

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http://dx.doi.org/10.2147/CMAR.S178979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260126PMC
November 2018
3 Reads

Hypothyroidism after craniospinal irradiation with proton or photon therapy in patients with medulloblastoma.

Pediatr Hematol Oncol 2018 May 11;35(4):257-267. Epub 2018 Dec 11.

b Texas Children's Cancer and Hematology Centers , Houston , Texas , USA.

Background: Craniospinal irradiation (CSI) often results in endocrine deficiencies in children with medulloblastoma due to irradiation of the hypothalamic-pituitary axis (HPA) or the thyroid gland. CSI with Proton radiation therapy (PRT) has the potential to decrease the risk of hypothyroidism by reduction in radiation dose to these organs. This study compares the risk for hypothyroidism in patients with medulloblastoma treated with Photon radiation therapy (XRT) or PRT. Read More

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http://dx.doi.org/10.1080/08880018.2018.1471111DOI Listing
May 2018
3 Reads

Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y.

Chem Biol Interact 2019 Feb 28;299:77-87. Epub 2018 Nov 28.

Redox Biology, Discipline of Pathology, The University of Sydney, Sydney, NSW, 2006, Australia. Electronic address:

Neuroblastoma is a common childhood cancer with high mortality. We evaluated the capacity of the flavonoid, isoliquiritigenin (4,2',4'-trihydroxychalcone; ISL) to inhibit cellular proliferation and migration in the human neuroblastoma cell line SH-SY5Y. Incubation of cultured SH-SY5Y cells with 20-100 μM ISL decreased cell confluency (15-70%) after 24 h incubation, while 10-100 μM ISL (24 h) depleted intracellular ATP stores (15-90% vs vehicle-treated control) after 24 h incubation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183022
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http://dx.doi.org/10.1016/j.cbi.2018.11.022DOI Listing
February 2019
11 Reads

Childhood Medulloblastoma Revisited.

Top Magn Reson Imaging 2018 Dec;27(6):479-502

Section of Neuroimaging, St. Jude Children's Research Hospital, Memphis, TN.

Medulloblastoma is the most common malignant solid tumor in childhood and the most common embryonal neuroepithelial tumor of the central nervous system. Several morphological variants are recognized: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity. Recent advances in transcriptome and methylome profiling of these tumors led to a molecular classification that includes 4 major genetically defined groups. Read More

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http://dx.doi.org/10.1097/RMR.0000000000000184DOI Listing
December 2018
14 Reads

Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma.

J Immunol Res 2018 30;2018:8097398. Epub 2018 Oct 30.

Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.

Neuroblastoma (NB) and malignant melanoma (MM), tumors of pediatric age and adulthood, respectively, share a common origin, both of them deriving from the neural crest cells. Although NB and MM have a different behavior, in respect to age of onset, primary tissue involvement and metastatic spread, the prognosis for high stage-affected patients is still poor, in spite of aggressive treatment strategies and the huge amount of new discovered biological knowledge. For these reasons researchers are continuously attempting to find out new treatment options, which in a near future could be translated to the clinical practice. Read More

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https://www.hindawi.com/journals/jir/2018/8097398/
Publisher Site
http://dx.doi.org/10.1155/2018/8097398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232800PMC
January 2019
10 Reads

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.

Oxid Med Cell Longev 2018 28;2018:9595741. Epub 2018 Oct 28.

Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei 10507, Taiwan.

Misfolded tau proteins induce accumulation of free radicals and promote neuroinflammation by activating microglia-releasing proinflammatory cytokines, leading to neuronal cell death. Traditional Chinese herbal medicines (CHMs) have been widely used in clinical practice to treat neurodegenerative diseases associated with oxidative stress and neuroinflammation. This study examined the neuroprotection effects of formulated CHMs Bai-Shao (made of ), Gan-Cao (made of ), and Shaoyao Gancao Tang (SG-Tang, made of and at 1 : 1 ratio) in cell model of tauopathy. Read More

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http://dx.doi.org/10.1155/2018/9595741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230396PMC
January 2019
1 Read

Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice.

Oxid Med Cell Longev 2018 30;2018:4070935. Epub 2018 Oct 30.

Institute of Nutritional Sciences, Laboratory for Nutrition in Prevention and Therapy, Justus-Liebig-University of Giessen, Biomedical Research Center Seltersberg (BFS), Schubertstr. 81, 35390 Giessen, Germany.

Aging represents a major risk factor for developing neurodegenerative diseases such as Alzheimer's disease (AD). As components of the Mediterranean diet, olive polyphenols may play a crucial role in the prevention of AD. Since mitochondrial dysfunction acts as a final pathway in both brain aging and AD, respectively, the effects of a mixture of highly purified olive secoiridoids were tested on cognition and ATP levels in a commonly used mouse model for brain aging. Read More

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http://dx.doi.org/10.1155/2018/4070935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232801PMC
January 2019

Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.

Eur J Med Chem 2019 Feb 22;163:83-94. Epub 2018 Nov 22.

Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville, 7535, South Africa. Electronic address:

The multifactorial pathophysiology of neurodegenerative disorders remains one of the main challenges in the design of a single molecule that may ultimately prevent the progression of these disorders in affected patients. In this article, we report on twelve novel polycyclic amine cage derivatives, synthesized with or without a propargylamine function, designed to possess inherent multifunctional neuroprotective activity. The MTT cytotoxicity assay results showed the SH-SY5Y human neuroblastoma cells to be viable with the twelve compounds, particularly at concentrations less than 10 μM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183101
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http://dx.doi.org/10.1016/j.ejmech.2018.11.051DOI Listing
February 2019
7 Reads

Experience with 102 Frameless Stereotactic Biopsies Using the neuromate Robotic Device.

World Neurosurg 2019 Mar 27;123:e450-e456. Epub 2018 Nov 27.

Department of Neurosurgery, Bethel Clinic, Bielefeld, Germany. Electronic address:

Objective: Stereotactic biopsy is a standard procedure in neurosurgery. In addition to or even replacing frame-based stereotaxy, some centers also use frameless imaging-based techniques and more recently robotic systems. Here we report a retrospective analysis of our experience with 102 consecutive biopsies performed in our institution using the neuromate robotic device. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.187DOI Listing
March 2019
4 Reads

Clinical Features and Long-Term Outcome of Primary Intracranial Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumors: 14 Cases From a Single Institution.

World Neurosurg 2019 Feb 26;122:e1606-e1614. Epub 2018 Nov 26.

Department of Neurosurgery, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:

Objective: Primary intracranial Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare, and only a few studies have reported >4 cases of this disease. The purpose of this study was to explore the clinical features, treatment, and outcome of primary intracranial ES/pPNETs.

Methods: The clinical data of 14 patients who had been surgically treated from February 2003 to November 2017 and in whom immunohistochemical staining results had confirmed the diagnosis of primary intracranial ES/pPNETs were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.151DOI Listing
February 2019
1 Read

Ewing's sarcoma of kidney in a 60-year-old patient with local recurrence: A rare occurrence.

J Cancer Res Ther 2018 Oct-Dec;14(6):1422-1424

Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.

Ewing's family of tumors is aggressive tumors and frequently arises from bone and soft tissue. They might also arise from nonosseous structures such as gastrointestinal tract, adrenal glands, or kidney. Primary renal Ewing's sarcoma (ES)/primitive neuroectodermal tumor is an extremely rare entity which has aggressive clinical course. Read More

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http://dx.doi.org/10.4103/0973-1482.191062DOI Listing
February 2019
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FAK and S6K1 Inhibitor, Neferine, Dually Induces Autophagy and Apoptosis in Human Neuroblastoma Cells.

Molecules 2018 Nov 28;23(12). Epub 2018 Nov 28.

Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Shoufeng, Hualien 97401, Taiwan.

Human neuroblastoma cancer is the most typical extracranial solid tumor. Yet, new remedial treatment therapies are demanded to overcome its sluggish survival rate. Neferine, isolated from the lotus embryos, inhibits the proliferation of various cancer cells. Read More

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http://www.mdpi.com/1420-3049/23/12/3110
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http://dx.doi.org/10.3390/molecules23123110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321370PMC
November 2018
13 Reads

Microenvironment in neuroblastoma: isolation and characterization of tumor-derived mesenchymal stromal cells.

BMC Cancer 2018 Nov 27;18(1):1176. Epub 2018 Nov 27.

Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas (NB-MSCs) to define interactions with the tumor microenvironment.

Methods: Specimens were obtained from 7 pediatric patients diagnosed with neuroblastoma (NB). Read More

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http://dx.doi.org/10.1186/s12885-018-5082-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260687PMC
November 2018
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50 Years Ago in The Journal of Pediatrics: Survival of Children with Neuroblastoma Treated with Combination Chemotherapy.

J Pediatr 2018 12;203:233

Texas Children's Cancer Center and Hematology Center Houston, Texas.

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http://dx.doi.org/10.1016/j.jpeds.2018.06.015DOI Listing
December 2018
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Comparing Kadish, TNM, and the modified Dulguerov staging systems for esthesioneuroblastoma.

J Surg Oncol 2019 Jan 22;119(1):130-142. Epub 2018 Nov 22.

Department of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Esthesioneuroblastoma (ENB) is a rare neuroendocrine tumor. The purpose of this study was to compare the Kadish, tumor-node-metastasis (TNM), and Dulguerov's modified TNM staging in order to determine the impact of the stage on primary surgical treatment selection, margin status, and survival.

Methods: The National Cancer Database (NCDB) was used to identify patients diagnosed with ENB between 2004 to 2015. Read More

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http://dx.doi.org/10.1002/jso.25293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352736PMC
January 2019
15 Reads

Sellar Embryonal Tumor: A Case Report and Review of the Literature.

Asian J Neurosurg 2018 Oct-Dec;13(4):1197-1201

Department of Neurosurgery, Ankara University, Ankara, Turkey.

Primitive neuroectodermal tumors (PNETs) are aggressive, poorly differentiated tumors in children and young adults. However, the embryonal tumor group did not include the central nervous system (CNS) PNET title and ependymoblastoma subtitle in the 2016 World Health Organization CNS tumor classification. Here, we report the case of a 6-year-old boy with a sellar embryonal tumor and present a review of the related literature. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_30_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208192PMC
November 2018
13 Reads

Pediatric Intracranial Tumors over a 5-Year Period in a Tertiary Care Center of North Kerala, India: A Retrospective Analysis.

Asian J Neurosurg 2018 Oct-Dec;13(4):1112-1117

Department of Neurosurgery, Government Medical College, Kozhikode, Kerala, India.

Background: Pediatric brain tumors are unique in terms of distribution, clinical presentation, pathologic types, management, and prognosis. There are not many studies from India which have looked into the epidemiology of pediatric brain tumors.

Aims: This study aimed to analyze the epidemiology of pediatric brain tumors in North Kerala and compare it with data from the rest of India and other countries. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_251_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208207PMC
November 2018
2 Reads

ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay.

Proc Natl Acad Sci U S A 2018 12 19;115(51):E11904-E11913. Epub 2018 Nov 19.

Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536;

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by preferential motor neuron death. Approximately 15% of ALS cases are familial, and mutations in the () gene contribute to a subset of familial ALS cases. FUS is a multifunctional protein participating in many RNA metabolism pathways. Read More

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http://dx.doi.org/10.1073/pnas.1810413115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304956PMC
December 2018
4 Reads

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.

Nat Commun 2018 11 19;9(1):4866. Epub 2018 Nov 19.

Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.

Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defined super-enhancers and identify TBX2 as top candidate gene. We show that TBX2 is a constituent of the recently established core regulatory circuitry in neuroblastoma with features of a cell identity transcription factor, driving proliferation through activation of p21-DREAM repressed FOXM1 target genes. Read More

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http://www.nature.com/articles/s41467-018-06699-9
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http://dx.doi.org/10.1038/s41467-018-06699-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242972PMC
November 2018
28 Reads

Accumulation of protoporphyrin IX in medulloblastoma cell lines and sensitivity to subsequent photodynamic treatment.

J Photochem Photobiol B 2018 Dec 7;189:298-305. Epub 2018 Nov 7.

Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Hospital, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

Background: Medulloblastoma (MB) is the most common malignant primary brain tumor of childhood. High risk patients still have a poor outcome, and especially young patients suffer from standard therapy induced sequelae. Therefore, other therapeutic options need to be explored. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10111344183104
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http://dx.doi.org/10.1016/j.jphotobiol.2018.11.002DOI Listing
December 2018
26 Reads

The safety of dinutuximab for the treatment of pediatric patients with high-risk neuroblastoma.

Expert Opin Drug Saf 2018 Dec 28;17(12):1257-1262. Epub 2018 Nov 28.

a Department of Pediatric Hematology Oncology, Baylor College of Medicine , Texas Children's Hospital , Houston , USA.

Introduction: Dinutuximab, an anti-GD2 antibody, specifically targets the high-expression of GD2 on neuroblastoma cells, and its incorporation into maintenance high-risk neuroblastoma therapy has increased event-free survival for this devastating disease. Efficacy of dinutuximab during other phases of therapy or in relapsed and refractory patients remains under investigation. Areas covered: This review looked at available publications (via PubMed search and online abstract catalogs of recent scientific meetings) on pre-clinical safety studies of dinutuximab as well as results and current impressions of pending trials including dinutuximab and other anti-GD2 antibodies. Read More

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http://dx.doi.org/10.1080/14740338.2018.1549221DOI Listing
December 2018
4 Reads