1,574 results match your criteria Primary and Secondary Prevention of Coronary Artery Disease


Pros and cons of antithrombotic therapy in end-stage kidney disease: a 2019 update.

Nephrol Dial Transplant 2019 Mar 16. Epub 2019 Mar 16.

the Academy of Romanian Scientists (AOSR).

Dialysis patients manifest both an increased thrombotic risk and a haemorrhagic tendency. A great number of patients with chronic kidney disease requiring dialysis have cardiovascular comorbidities (coronary artery disease, atrial fibrillation or venous thromboembolism) and different indications for treatment with antithrombotics (primary or secondary prevention). Unfortunately, few randomized controlled trials deal with antiplatelet and/or anticoagulant therapy in dialysis. Read More

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http://dx.doi.org/10.1093/ndt/gfz040DOI Listing

Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan.

Circ J 2019 Mar 13. Epub 2019 Mar 13.

Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine.

Background: Trans-fatty acid (TFA) intake increases the risk of coronary artery disease (CAD). Our previous cross-sectional survey showed that middle-aged patients with CAD in Japan have elevated serum TFA. In this study, we longitudinally investigated whether elevated TFA is a risk factor in the secondary prevention of CAD for the same-age patients. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1175DOI Listing

Comparison of cardiovascular risk factors among coronary artery bypass graft patients in 2010 and 2016: A single-center study in Guilan province, Iran.

ARYA Atheroscler 2018 Sep;14(5):205-211

Associate Professor, Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Background: There has been a change in the risk factor profile of patients with coronary artery disease (CAD) in the western world. We sought to compare the risk factor profile of patients undergoing coronary artery bypass graft (CABG) surgery in northern part of Iran in 2010 and 2016.

Methods: In a cross-sectional study, medical records of 296 CABG patients in 2010 and 500 patients in 2016 were collected from a referral university hospital in Guilan province, Iran. Read More

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http://dx.doi.org/10.22122/arya.v14i5.1740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368195PMC
September 2018
1 Read

Multicentre, open-label, randomised controlled clinical trial to assess the efficacy and safety of appropriate target values for lipid management in patients who have mild-to-moderate stenotic lesions with high-risk plaques in coronary arteries: study protocol.

BMJ Open 2019 Jan 25;9(1):e022843. Epub 2019 Jan 25.

Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Introduction: To detect patients at high risk of developing myocardial infarction, plaque characteristics as well as the degree of stenosis in coronary arteries should be evaluated. However, unstable plaque or severe calcification detected via coronary artery CT (CACT) is not reflected in risk stratification according to current guidelines. It is hypothesised that patients with high-risk findings on CACT (even those without proven history of coronary artery diseases; CAD) should be strictly managed to lower their low-density lipoprotein cholesterol (LDL-C) levels to targets of secondary prevention. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347913PMC
January 2019
2 Reads

Glycaemic variability is associated with severity of coronary artery disease in patients with poorly controlled type 2 diabetes and acute myocardial infarction.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Cardiology Department, University Hospital Center, 21000 Dijon Bourgogne, France.

Background: In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD).

Objectives: The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admitted for acute myocardial infarction (AMI).

Methods: All patients with T2D admitted to our university hospital for AMI from March 2015 to February 2017 who received intravenous (IV) insulin therapy and underwent coronary angiography were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12623636193002
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http://dx.doi.org/10.1016/j.diabet.2019.01.012DOI Listing
February 2019
9 Reads

Cardioprotective Effect of Statins in Patients With HER2-Positive Breast Cancer Receiving Trastuzumab Therapy.

Can J Cardiol 2019 Feb 4;35(2):153-159. Epub 2018 Dec 4.

Division of Cardiology, Peter Munk Cardiac Center, Ted Rogers Program in Cardiotoxicity Prevention, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Statins can reduce the risk of anthracycline-induced cardiotoxicity. Whether such cardioprotective effects can be seen in trastuzumab-treated patients has not been explored.

Methods: Consecutive women with HER2+ breast cancer who received trastuzumab with or without anthracyclines were identified retrospectively. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.028DOI Listing
February 2019
1 Read

Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry.

Eur J Prev Cardiol 2019 Feb 10:2047487318825350. Epub 2019 Feb 10.

1 European Society of Cardiology, Sophia Antipolis, France.

Aims: The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice.

Design: A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries.

Methods: Patients (<80 years old) with verified coronary artery events or interventions were interviewed and examined ≥6 months later. Read More

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http://journals.sagepub.com/doi/10.1177/2047487318825350
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http://dx.doi.org/10.1177/2047487318825350DOI Listing
February 2019
6 Reads
2.675 Impact Factor

[Acetylsalicylic acid in the prevention and treatment of cardiovascular diseases].

Wiad Lek 2018 ;71(8):1608-1614

Katedra i Klinika Chorób Wewnętrznych, Diabetologii i Nefrologii, Śląski Uniwersytet Medyczny w Katowicach, Katowice, Polska.

Acetylsalicylic acid (ASA) is one of the most popular medicines in the world. ASA preparations have been used for over 100 years as anti-inflammatory, antipyretic and analgesic drugs. Since 1971, ASA has also been used as an antiplatelet drug. Read More

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January 2018
1 Read

The triglyceride paradox in the mortality of coronary artery disease.

Lipids Health Dis 2019 Jan 22;18(1):21. Epub 2019 Jan 22.

Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu, 610041, People's Republic of China.

Background: The role of triglyceride (TG) in secondary prevention of patients with coronary artery disease (CAD) was debated. In the present study, we assessed the association between admission TG levels and long-term mortality risk in CAD patients.

Methods: A retrospective analysis was conducted from a single registered database. Read More

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http://dx.doi.org/10.1186/s12944-019-0972-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343235PMC
January 2019
2 Reads

Stroke Outcomes in the COMPASS Trial.

Circulation 2019 Feb;139(9):1134-1145

McMaster University/Population Health Research Institute, Hamilton, Canada (M.S., R.G.H., S.J.C., J.B., O.S., K.K.H.N., L.C., S.Y., J.W.E.).

Background: Strokes were significantly reduced by the combination of rivaroxaban plus aspirin in comparison with aspirin in the COMPASS trial (Cardiovascular Outcomes for People Using Anticoagulation Strategies). We present detailed analyses of stroke by type, predictors, and antithrombotic effects in key subgroups.

Methods: Participants had stable coronary artery or peripheral artery disease and were randomly assigned to receive aspirin 100 mg once daily (n=9126), rivaroxaban 5 mg twice daily (n=9117), or rivaroxaban 2. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035864DOI Listing
February 2019
2 Reads

Effectiveness and cost-effectiveness of a Yoga-based Cardiac Rehabilitation (Yoga-CaRe) program following acute myocardial infarction: Study rationale and design of a multi-center randomized controlled trial.

Int J Cardiol 2019 Apr 7;280:14-18. Epub 2019 Jan 7.

Centre for Chronic Disease Control, New Delhi, India; London School of Hygiene and Tropical Medicine, London, UK; Public Health Foundation of India, Gurgaon, India; Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address:

Background: Cardiac rehabilitation (CR) is a standard treatment for secondary prevention of acute myocardial infarction (AMI) in high income countries (HICs), but it is inaccessible to most patients in India due to high costs and skills required for multidisciplinary CR teams. We developed a low-cost and scalable CR program based on culturally-acceptable practice of yoga (Yoga-CaRe). In this paper, we report the rationale and design for evaluation of its effectiveness and cost-effectiveness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183453
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http://dx.doi.org/10.1016/j.ijcard.2019.01.012DOI Listing
April 2019
7 Reads
4.036 Impact Factor

Lessons learned? Changes in dietary behavior after a coronary event.

Clin Nutr ESPEN 2019 Feb 18;29:112-118. Epub 2018 Dec 18.

Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. Electronic address:

Background And Aims: A healthy diet is recommended for the prevention of coronary artery disease (CAD), but whereas patients with CAD adhere to a healthy diet is unclear. We aimed to assess the impact of a CAD event on dietary intake.

Methods: Prospective, population-based, observational study conducted between 2009 and 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24054577183061
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http://dx.doi.org/10.1016/j.clnesp.2018.11.010DOI Listing
February 2019
8 Reads

Aspirin Use and Cardiovascular Outcome in Patients With Type 2 Diabetes Mellitus and Heart Failure: A Population-Based Cohort Study.

J Am Heart Assoc 2018 Nov;7(21):e010033

1 Joan and Sanford I. Weill Department of Medicine Weill Cornell Medicine Doha Qatar.

Background Aspirin is of uncertain benefit for primary prevention in patients with type 2 diabetes mellitus (T2D). We assessed whether primary prevention with aspirin is beneficial in patients with T2D and heart failure ( HF ). Methods and Results Data from The Health Improvement Network, a UK multicenter prospective primary care database, were analyzed. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.010033
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http://dx.doi.org/10.1161/JAHA.118.010033DOI Listing
November 2018
8 Reads

Disconcordance between ESC prevention guidelines and observed lipid profiles in patients with known coronary artery disease.

Int J Cardiol Heart Vasc 2019 Mar 28;22:73-77. Epub 2018 Dec 28.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany.

Background: We aimed to describe whether updated low-density lipoprotein (LDL)-targets in patients with manifest coronary artery disease (CAD) led to a change in lipid profile over time.

Methods: We retrospectively included patients with manifest CAD from 2009-2010, 2012-2013, and 2015-2016 (n = 500 each). Lipid levels and medication at the different time-points as well as rate of accordance to guidelines (<100 for 2009-2010, <70 mg/dl for 2012-2013 and 2015-2016) were evaluated. Read More

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http://dx.doi.org/10.1016/j.ijcha.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310742PMC
March 2019
1 Read

The association between olive oil consumption and primary prevention of cardiovascular diseases.

Authors:
Sameer Al-Ghamdi

J Family Med Prim Care 2018 Sep-Oct;7(5):859-864

Department of Family Medicine, College of Medicine, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia.

Introduction: American Heart Association and many other recommend Mediterranean diet for patients with cardiovascular risk. This systematic review and meta-analysis are conducted to review the effects of Mediterranean diet on the cardiovascular events as reported in randomized controlled trials (RCTs).

Methods: A systematic research is conducted on MEDLINE via Ovid, Embase, PubMed, Google Scholar, Web of Science, and Informit. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_191_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259537PMC
January 2019
1 Read

Low quality cardiovascular care is important coronary risk factor in India.

Indian Heart J 2018 Dec 17;70 Suppl 3:S419-S430. Epub 2018 May 17.

Department of Pharmacology, St John's Medical College, Bangalore, India.

Global Burden of Disease study has reported that cardiovascular and ischemic heart disease (IHD) mortality has increased by 34% in last 25 years in India. It has also been reported that despite having lower coronary risk factors compared to developed countries, incident cardiovascular mortality, cardiovascular events and case-fatality are greater in India. Reasons for the increasing trends and high mortality have not been studied. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309144PMC
December 2018
3 Reads

Changing patterns in the prevalence and management of cardiovascular risk factors in India and their comparison with the rest of the world along with clinical outcomes at 5-year: An analysis of stable coronary artery disease patients from The Prospective Observational Longitudinal Registry of patients with stable coronary artery disease (CLARIFY) registry.

Indian Heart J 2018 Dec 24;70 Suppl 3:S36-S42. Epub 2018 Apr 24.

Chairman and Dean Academics and Research, Batra Heart Center & Batra Hospital and Medical Research Center, Delhi, India.

Objective: Present paper describes trends in prevalence and control of cardiovascular risk factors and clinical outcomes at 5-years for CLARIFY Indian cohort compared with rest of the world (ROW).

Method: CLARIFY is an international, prospective-observational, longitudinal cohort study in stable coronary artery disease outpatients. The 5-year data of both cohorts were compared, and evaluated. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309139PMC
December 2018
3 Reads

Systematic Review for the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol.

Circulation 2018 Nov 10:CIR0000000000000626. Epub 2018 Nov 10.

Background: The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of blood cholesterol found little evidence to support the use of nonstatin lipid-modifying medications to reduce atherosclerotic cardiovascular disease (ASCVD) events. Since publication of these guidelines, multiple randomized controlled trials evaluating nonstatin lipid-modifying medications have been published.

Methods: We performed a systematic review to assess the magnitude of benefit and/or harm from additional lipid-modifying therapies compared with statins alone in individuals with known ASCVD or at high risk of ASCVD. Read More

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http://dx.doi.org/10.1161/CIR.0000000000000626DOI Listing
November 2018
2 Reads

Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease.

Circulation 2018 Nov 10:CIR0000000000000638. Epub 2018 Nov 10.

Risk assessment is a critical step in the current approach to primary prevention of atherosclerotic cardiovascular disease. Knowledge of the 10-year risk for atherosclerotic cardiovascular disease identifies patients in higher-risk groups who are likely to have greater net benefit and lower number needed to treat for both statins and antihypertensive therapy. Current U. Read More

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http://dx.doi.org/10.1161/CIR.0000000000000638DOI Listing
November 2018
1 Read
14.430 Impact Factor

Remote ischemic preconditioning for prevention of contrast induced nephropathy-Insights from an Indian study.

Indian Heart J 2018 Nov - Dec;70(6):857-863. Epub 2017 Nov 16.

Department of Cardiology, Government Medical College, Thiruvananthapuram, Kerala 695011, India.

Objectives: To study if four cycles of remote ischemic preconditioning (RIPC) could offer protection against contrast induced nephropathy (CIN) and post procedural renal dysfunction in high risk patients undergoing percutaneous coronary intervention (PCI).

Methods: This was a prospective single blind randomized sham controlled trial where patients undergoing coronary angioplasty with stage III chronic kidney disease were randomized into sham preconditioning and remote ischemic preconditioning. The primary outcome was the reduction in the incidence of CIN. Read More

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http://dx.doi.org/10.1016/j.ihj.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306307PMC
January 2019
3 Reads

Anti-Inflammatory Effects of a Vegan Diet Versus the American Heart Association-Recommended Diet in Coronary Artery Disease Trial.

J Am Heart Assoc 2018 Dec;7(23):e011367

1 Department of Medicine (Cardiology) New York University School of Medicine New York NY.

Background Dietary interventions may play a role in secondary cardiovascular prevention. hsCRP (High-sensitivity C-reactive protein) is a marker of risk for major adverse cardiovascular outcomes in coronary artery disease. Methods and Results The open-label, blinded end-point, EVADE CAD (Effects of a Vegan Versus the American Heart Association-Recommended Diet in Coronary Artery Disease) trial randomized participants (n=100) with coronary artery disease to 8 weeks of a vegan or American Heart Association-recommended diet with provision of groceries, tools to measure dietary intake, and dietary counseling. Read More

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http://dx.doi.org/10.1161/JAHA.118.011367DOI Listing
December 2018

Fish Oil and Perioperative Bleeding.

Circ Cardiovasc Qual Outcomes 2018 Nov;11(11):e004584

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.).

Background Fish oil is among the most common natural supplements for treatment of hypertriglyceridemia or prevention of cardiovascular disease. However, concerns about theoretical bleeding risk have led to recommendations that patients should stop taking fish oil before surgery or delay in elective procedures for patients taking fish oil by some health care professionals. Methods and Results We tested the effect of fish oil supplementation on perioperative bleeding in a multinational, placebo-controlled trial involving 1516 patients who were randomized to perioperative fish oil (eicosapentaenoic acid+docosahexaenoic acid; 8-10 g for 2-5 days preoperatively, and then 2 g/d postoperatively) or placebo. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376981PMC
November 2018
8 Reads

Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial.

JAMA 2018 12;320(22):2325-2334

Hemodialysis Center, Inoue Hospital, Soryu Medical Corporation, Osaka, Japan.

Importance: Patients with chronic kidney disease have impaired vitamin D activation and elevated cardiovascular risk. Observational studies in patients treated with hemodialysis showed that the use of active vitamin D sterols was associated with lower risk of all-cause mortality, regardless of parathyroid hormone levels.

Objective: To determine whether vitamin D receptor activators reduce cardiovascular events and mortality in patients without secondary hyperparathyroidism undergoing hemodialysis. Read More

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http://dx.doi.org/10.1001/jama.2018.17749DOI Listing
December 2018
4 Reads

Is there a gender gap in secondary prevention of coronary artery disease in Turkey?

Turk Kardiyol Dern Ars 2018 12;46(8):683-691

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: It has been reported that women receive fewer preventive recommendations regarding pharmacological treatment, lifestyle modifications, and cardiac rehabilitation compared with men who have a similar risk profile. This study was an investigation of the impact of gender on cardiovascular risk profile and secondary prevention measures for coronary artery disease (CAD) in the Turkish population.

Methods: Statistical analyses were based on the European Action on Secondary and Primary Prevention through Intervention to Reduce Events (EUROASPIRE)-IV cross-sectional survey data obtained from 17 centers in Turkey. Read More

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http://dx.doi.org/10.5543/tkda.2018.10.5543/tkda.2018.45392DOI Listing
December 2018
4 Reads

Prognostic value of frontal QRS-T angle in patients undergoing myocardial revascularization or cardiac valve surgery.

J Electrocardiol 2018 Nov - Dec;51(6):967-972. Epub 2018 Aug 23.

Department of Medicine and Surgery, University of Parma, Italy.

Background: An abnormal frontal QRS-T angle (fQRSTa) is associated with increased risk of death in primary and secondary cardiovascular prevention. The aim of this study was to evaluate the fQRSTa prognostic role in patients undergoing myocardial revascularization and/or cardiac valve surgery.

Methods: We enrolled and prospectively followed for 48 ± 26 months 939 subjects with available QRS and T axis data; mean age was 68 ± 12 years, 449 patients (48%) underwent myocardial revascularization, 333 (35%) cardiac valve surgery, 94 (10%) valve plus bypass graft surgery and 63 (7%) cardiac surgery for other cardiovascular (CV) diseases. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2018.08.028DOI Listing
August 2018
5 Reads
1.363 Impact Factor

Clinical use of cardiac troponin for acute cardiac care and emerging opportunities in the outpatient setting.

Minerva Med 2019 Apr 27;110(2):139-156. Epub 2018 Nov 27.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Cardiac troponin (cTn) testing has evolved significantly in recent times. Because of increased sensitivity, its use has shifted from a marker used to help diagnose acute myocardial infarction (MI) to a marker than can be used in the outpatient setting, as well as for both detection of myocardial injury and risk-stratification. Its main role remains in the diagnosis of acute MI and the risk-stratification of patients presenting with suspected acute coronary syndrome. Read More

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http://dx.doi.org/10.23736/S0026-4806.18.05874-3DOI Listing
April 2019
3 Reads

Update on prevention and treatment of sudden cardiac arrest.

Trends Cardiovasc Med 2018 Nov 6. Epub 2018 Nov 6.

UCLA Cardiac Arrhythmia Center, UCLA Health System, David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, Suite 660, Los Angeles, CA, USA. Electronic address:

Sudden cardiac arrest is the leading cause of cardiovascular mortality, posing a substantial public health burden. The incidence and epidemiology of sudden death are a function of age, with primary arrhythmia syndromes and inherited cardiomyopathies representing the predominant causes in younger patients, while coronary artery disease being the leading etiology in those who are 35 years of age and older. Internal cardioverter defibrillators remain the mainstay of primary and secondary prevention of sudden cardiac arrest. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10501738183025
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http://dx.doi.org/10.1016/j.tcm.2018.11.002DOI Listing
November 2018
19 Reads

Unprotected versus protected high-risk percutaneous coronary intervention with the Impella 2.5 in patients with multivessel disease and severely reduced left ventricular function.

Medicine (Baltimore) 2018 Oct;97(43):e12665

First Department of Medicine-Cardiology, University Medical Centre Mannheim.

Selecting a revascularization strategy in patients with multivessel disease (MVD) and severely reduced left ventricular ejection fraction (LVEF) remains a challenge. PCI with Impella 2.5 may facilitate high-risk PCI, however long-term results comparing unprotected versus protected PCI are currently unknown. Read More

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http://dx.doi.org/10.1097/MD.0000000000012665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221604PMC
October 2018
21 Reads

High-Intensity Versus Non-High-Intensity Statins in Patients Achieving Low-Density Lipoprotein Cholesterol Goal After Percutaneous Coronary Intervention.

J Am Heart Assoc 2018 Nov;7(21):e009517

1 Division of Cardiology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.

Background Whether use of high-intensity statins is more important than achieving low-density lipoprotein cholesterol ( LDL -C) target remains controversial in patients with coronary artery disease. We sought to investigate the association between statin intensity and long-term clinical outcomes in patients achieving treatment target for LDL -C after percutaneous coronary intervention. Methods and Results Between February 2003 and December 2014, 1746 patients who underwent percutaneous coronary intervention and achieved treatment target for LDL -C (<70 mg/dL or >50% reduction from baseline level) were studied. Read More

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http://dx.doi.org/10.1161/JAHA.118.009517DOI Listing
November 2018
2 Reads

Induction immunosuppression agents as risk factors for incident cardiovascular events and mortality after kidney transplantation.

Am J Transplant 2018 Oct 29. Epub 2018 Oct 29.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Low T cell counts and acute rejection are associated with increased cardiovascular events (CVEs); T cell-depleting agents decrease both. Thus, we aimed to characterize the risk of CVEs by using an induction agent used in kidney transplant recipients. We conducted a secondary data analysis of patients who received a kidney transplant and used Medicare as their primary insurance from 1999 to 2010. Read More

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http://dx.doi.org/10.1111/ajt.15148DOI Listing
October 2018
1 Read

Estimated Life Expectancy Without Recurrent Cardiovascular Events in Patients With Vascular Disease: The SMART-REACH Model.

J Am Heart Assoc 2018 Aug;7(16):e009217

1 Department of Vascular Medicine University Medical Centre Utrecht The Netherlands.

Background In patients with vascular disease, risk models may support decision making on novel risk reducing interventions, such as proprotein convertase subtilisin/kexin type 9 inhibitors or anti-inflammatory agents. We developed and validated an innovative model to estimate life expectancy without recurrent cardiovascular events for individuals with coronary, cerebrovascular, and/or peripheral artery disease that enables estimation of preventive treatment effect in lifetime gained. Methods and Results Study participants originated from prospective cohort studies: the SMART (Secondary Manifestations of Arterial Disease) cohort and REACH (Reduction of Atherothrombosis for Continued Health) cohorts of 14 259 ( REACH Western Europe), 19 170 ( REACH North America) and 6959 ( SMART , The Netherlands) patients with cardiovascular disease. Read More

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http://dx.doi.org/10.1161/JAHA.118.009217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201391PMC
August 2018
3 Reads

Primary Prevention Using Cholesterol-Lowering Medications in Patients Meeting New Treatment Guidelines: A Retrospective Cohort Analysis.

J Manag Care Spec Pharm 2018 Nov;24(11):1078-1085

1 Department of Pharmaceutical and Health Economics, School of Pharmacy, Leonard Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles.

Background: The American College of Cardiology and American Heart Association (ACC/AHA) issued new cholesterol treatment guidelines in 2013. Two of the groups designated for primary prevention were analyzed: patients with a low-density lipoprotein cholesterol (LDL-C) level ≥ 190 mg per dL and diabetic patients aged 40-75 years.

Objective: To estimate the effects of primary prevention as specified in the 2013 guidelines on cardiovascular event risk and cost. Read More

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https://www.jmcp.org/doi/10.18553/jmcp.2018.24.11.1078
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http://dx.doi.org/10.18553/jmcp.2018.24.11.1078DOI Listing
November 2018
2 Reads

Silent atrial fibrillation in patients with an implantable cardioverter defibrillator and coronary artery disease (INDICO AF) trial: study rationale and design.

Neth Heart J 2018 Dec;26(12):628-633

Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Timely detection of atrial fibrillation (AF) in implantable cardioverter defibrillator (ICD) patients is clinically important for prevention of AF-related complications and inappropriate shocks. Patients with coronary artery disease (CAD) and a dual or triple chamber ICD show a high incidence of device-detected AF. Whether CAD patients with a single chamber ICD carry a similar risk for device-detected AF remains unknown. Read More

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http://link.springer.com/10.1007/s12471-018-1185-2
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http://dx.doi.org/10.1007/s12471-018-1185-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288037PMC
December 2018
10 Reads

Incidence of cardiovascular events in patients with stabilized coronary heart disease: the EUROASPIRE IV follow-up study.

Eur J Epidemiol 2018 Oct 23. Epub 2018 Oct 23.

Department of Public Health, Ghent University, De Pintelaan 185, 4K3, 9000, Ghent, Belgium.

The EUROASPIRE surveys (EUROpean Action on Secondary Prevention through Intervention to Reduce Events) demonstrated that most European coronary patients fail to achieve lifestyle, risk factor and therapeutic targets. Here we report on the 2-year incidence of hard cardiovascular (CV) endpoints in the EUROASPIRE IV cohort. EUROASPIRE IV (2012-2013) was a large cross-sectional study undertaken at 78 centres from selected geographical areas in 24 European countries. Read More

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http://link.springer.com/10.1007/s10654-018-0454-0
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http://dx.doi.org/10.1007/s10654-018-0454-0DOI Listing
October 2018
10 Reads
5.340 Impact Factor

Emerging Research on the Implications of Hormone Replacement Therapy on Coronary Heart Disease.

Curr Atheroscler Rep 2018 Oct 22;20(12):57. Epub 2018 Oct 22.

Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.

Purpose Of Review: Cardiovascular disease (CVD) is known to be an increasing cause of mortality among women, particularly postmenopausal women. Hormone replacement therapy (HRT) is a topic that has been investigated over the past decade for its known impact on the cardiovascular system. This review summarizes the evidence and current opinion on the associations between HRT and CVD, evidence both supporting and against HRT use as a prevention to the development of coronary heart disease (CHD). Read More

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http://dx.doi.org/10.1007/s11883-018-0758-2DOI Listing
October 2018
3 Reads

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study.

Am Heart J 2018 Dec 29;206:80-93. Epub 2018 Sep 29.

Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Observational, genetic, and experimental data indicate that triglyceride rich lipoproteins (TRLs) likely participate causally in atherothrombosis. Yet, robust clinical trial evidence that triglyceride (TG) lowering therapy reduces cardiovascular events remains elusive. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARM-α), pemafibrate, will be used to target residual cardiovascular risk remaining after treatment to reduce low-density lipoprotein cholesterol (LDL-C) in individuals with the dyslipidemia of type 2 diabetes mellitus (T2). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00028703183028
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http://dx.doi.org/10.1016/j.ahj.2018.09.011DOI Listing
December 2018
17 Reads

Secondary prevention of cardiovascular diseases: current state of the art.

Authors:
Gerd Hasenfuß

Kardiol Pol 2018;76(12):1671-1679. Epub 2018 Oct 19.

Prevention strategies for cardiac events depend of the risk for such an event. A very high risk is defined as a risk > 10% over 10 years. For example, a patient with known coronary artery disease has such a very high risk of death. Read More

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https://ojs.kardiologiapolska.pl/kp/article/view/12664
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http://dx.doi.org/10.5603/KP.a2018.0198DOI Listing
October 2018
23 Reads

Anticoagulation in Atherosclerotic Disease.

Hamostaseologie 2018 Nov 17;38(4):240-246. Epub 2018 Oct 17.

Department of Cardiology and Angiology I, Heart Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

The prevention of atherothrombotic events is an essential therapeutic goal in the treatment of patients with arteriosclerotic diseases. After plaque rupture, a rapidly growing thrombus can lead to acute vascular occlusion and thus heart attack, stroke or limb ischaemia. The acute therapy combines anticoagulation and platelet inhibition. Read More

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http://dx.doi.org/10.1055/s-0038-1673412DOI Listing
November 2018
22 Reads
1.590 Impact Factor

RoPE Score as a Predictor of Recurrent Ischemic Events After Percutaneous Patent Foramen Ovale Closure.

Int Heart J 2018 Nov 10;59(6):1327-1332. Epub 2018 Oct 10.

Cardiology University Centre, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central.

The benefits of patent foramen ovale (PFO) closure for cryptogenic stroke secondary prevention are still debated. The Risk of Paradoxical Embolism (RoPE) study developed a score to improve patient selection for this procedure. We proposed to assess the validity of this score to assess the prognostic impact of PFO closure. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_17-
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http://dx.doi.org/10.1536/ihj.17-489DOI Listing
November 2018
32 Reads

Outcomes of Chimney Technique for Preservation of the Left Subclavian Artery in Type B Aortic Dissection.

Eur J Vasc Endovasc Surg 2018 Oct 5. Epub 2018 Oct 5.

Department of Cardiology, Vascular Centre, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

Objective: To report outcomes of the chimney technique for preservation of the left subclavian artery (LSA) in patients with type B aortic dissection (TBAD).

Methods: A retrospective analysis was performed of a prospectively maintained database from August 2012 to October 2017. Primary endpoints were 30 day and overall mortality. Read More

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http://dx.doi.org/10.1016/j.ejvs.2018.09.005DOI Listing
October 2018
4 Reads
2.490 Impact Factor

Effects of comprehensive cardiac rehabilitation on functional capacity in a middle-income country: a randomised controlled trial.

Heart 2018 Oct 3. Epub 2018 Oct 3.

Physical Therapy Department, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Objective: Despite the growing epidemic of cardiovascular diseases in middle-income countries, there is insufficient evidence about cardiac rehabilitation (CR) in these countries. Thus, the effects of comprehensive CR on functional capacity and risk factors were investigated in Brazil, to test the hypothesis that it results in better outcomes than exercise-only or no CR.

Methods: Single-blinded, randomised controlled trial with three parallel arms: comprehensive CR (exercise+education) versus exercise-only CR versus wait-list control. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-313632
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http://dx.doi.org/10.1136/heartjnl-2018-313632DOI Listing
October 2018
16 Reads

Use of beta-blocker is associated with lower mortality in patients with coronary artery disease with or without COPD.

Clin Respir J 2018 Dec 4;12(12):2627-2634. Epub 2018 Nov 4.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Introduction: Beta-blockers are indicated for secondary prevention of coronary artery disease (CAD). However, in patients with co-morbidity of chronic obstructive pulmonary disease (COPD) an underuse of beta-blocker has been reported.

Materials And Methods: Prescription and demographic data and information on hospital discharge diagnoses from 13 Austrian health insurance funds for the years 2006-2007 were analyzed. Read More

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http://doi.wiley.com/10.1111/crj.12968
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http://dx.doi.org/10.1111/crj.12968DOI Listing
December 2018
11 Reads

Clinical Characteristics of Patients with co-Existent Diabetic Peripheral Neuropathy and Depression: A Systematic Review.

Exp Clin Endocrinol Diabetes 2018 Sep 26. Epub 2018 Sep 26.

2nd Department of Internal Medicine, Research Institute and Diabetes Centre, National and Kapodistrian University of Athens, Attikon University Hospital, Haidari, Athens, Greece.

Objectives: Both diabetic peripheral neuropathy and depression have significant implications on patients' quality of life, management and outcomes. We aimed to evaluate all available evidence concerning patients with co-existent diabetic peripheral neuropathy and depression, and describe their clinical characteristics, in order to promote early recognition and management.

Methods: Systematic search of PubMed for studies providing data on patients with diabetic peripheral neuropathy and depression. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0741-6937
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http://dx.doi.org/10.1055/a-0741-6937DOI Listing
September 2018
28 Reads

Prevention of atherothrombotic events in patients with diabetes mellitus: from antithrombotic therapies to new-generation glucose-lowering drugs.

Nat Rev Cardiol 2019 Feb;16(2):113-130

Institute of Cardiology, G. d'Annunzio University, Chieti, Italy.

Diabetes mellitus is an important risk factor for a first cardiovascular event and for worse outcomes after a cardiovascular event has occurred. This situation might be caused, at least in part, by the prothrombotic status observed in patients with diabetes. Therefore, contemporary antithrombotic strategies, including more potent agents or drug combinations, might provide greater clinical benefit in patients with diabetes than in those without diabetes. Read More

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http://dx.doi.org/10.1038/s41569-018-0080-2DOI Listing
February 2019
19 Reads

Radial vs femoral access for the prevention of acute kidney injury (AKI) after coronary angiography or intervention: A systematic review and meta-analysis.

Catheter Cardiovasc Interv 2018 Dec 23;92(7):E518-E526. Epub 2018 Sep 23.

Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.

Objectives: We sought to investigate the impact of radial vs femoral access on the incidence of acute kidney injury (AKI) after coronary angiography or intervention.

Background: There is a growing recognition of the importance of access site selection as an adjudicative measure to mitigate the risk of renal impairment for patients with coronary artery disease undergoing angiography with or without percutaneous coronary intervention.

Methods: We conducted a systematic review of the literature and meta-analyzed available evidence comparing the rates of AKI with radial vs femoral access in patients undergoing coronary angiography or intervention. Read More

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http://dx.doi.org/10.1002/ccd.27903DOI Listing
December 2018
4 Reads

Impact of type D personality on clinical outcomes in Asian patients with stable coronary artery disease.

J Formos Med Assoc 2019 Mar 19;118(3):721-729. Epub 2018 Sep 19.

Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan.

Background: Some personality types are associated with cardiovascular (CV) diseases and may be related to clinical outcomes in coronary artery disease (CAD). This study investigates the association between type D personality and clinical outcomes in stable CAD patients in an Asian cohort.

Methods: Stable CAD patients were enrolled and prospectively followed up for at least 1 year in Taiwan. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.08.021DOI Listing
March 2019
3 Reads

Rationale and design of randomized controlled trial protocol of cardiovascular rehabilitation based on the use of telemedicine technology in the Czech Republic (CR-GPS).

Medicine (Baltimore) 2018 Sep;97(37):e12385

Department of Internal Cardiology Medicine- Institutions Shared with the Faculty Hospital Brno-Adult Age Medicine-Faculty of Medicine Brno, Brno, Czech Republic.

Background: Cardiovascular diseases remain the most common causes of death in the world. Instructions for secondary prevention recommend multifaceted approach in cardiovascular diseases risk management. Center-based physical exercise training is considered as an important integral part of cardiac rehabilitation (CR). Read More

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http://dx.doi.org/10.1097/MD.0000000000012385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156058PMC
September 2018
27 Reads

CPAP effects on atherosclerotic plaques in patients with sleep-disordered breathing and coronary artery disease: The ENTERPRISE trial.

J Cardiol 2019 Jan 31;73(1):89-93. Epub 2018 Aug 31.

Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Background: Sleep-disordered breathing (SDB) is a novel cardiovascular risk factor. To date, the effects of continuous positive airway pressure (CPAP) on coronary plaque atheroma in SDB patients with coronary artery disease (CAD) have remained unclear. The CPAP Effects on Atherosclerotic Plaques in Patients with Sleep-Disordered Breathing and Coronary Artery Disease (ENTERPRISE) trial was designed to evaluate the effects of CPAP treatment in addition to optimal medical treatment on coronary plaque regression in SDB patients. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.07.002DOI Listing
January 2019
3 Reads